Page last updated: 2024-10-19

nitrous oxide and Necrosis

nitrous oxide has been researched along with Necrosis in 15 studies

Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"This article describes the treatment of hemangiomas of the lip by cryosurgery and, in particular, evaluates the effectiveness of freezing in nitrous oxide cryosurgery on these lesions."1.28Cryosurgical treatment of hemangiomas of the lip. ( Tal, H, 1992)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19908 (53.33)18.7374
1990's3 (20.00)18.2507
2000's1 (6.67)29.6817
2010's2 (13.33)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Wu, Y1
Hu, Y1
Wang, S1
Xu, B1
Xu, Y1
Chen, H1
Luo, L1
Ran, L1
Rasool, QZ1
Cohan, DS1
Serin, M1
Altinel, D1
Leblebici, C1
Biltekin, B1
Huseyinbas, O1
Kurt Yazar, S1
Irmak, F1
Sonmez, A1
Bayramicli, M1
Cremer, M1
Ditzian, L1
Winkler, JL1
Jerónimo, J2
Singleton, J1
Franco, HV1
Maza, M1
Conlisk, E1
Gage, J1
Castle, P1
Santos, C2
Mariategui, J1
Taxa, L1
Castle, PE1
Katz, J1
Magee, J1
Baker, B1
Eger, EI2
Jevtović-Todorović, V1
Todorović, SM1
Mennerick, S1
Powell, S1
Dikranian, K1
Benshoff, N1
Zorumski, CF1
Olney, JW1
Tal, H1
Fisher, NA1
Iwata, RT1
Smuckler, EA1
Brierley, JB1
Miller, AA1
Breithardt, G1
Knieriem, HJ1
Schuier, FJ1
Herold, R1
Hischebeth, G1
Siess, M1
Stofer, AR1
Läuppi, E1
Nesvetov, AM1
Dovgiĭ, GM1
L'vova, TN1
Hills, BA1
Straley, R1
Droegemueller, W1
Makowski, E1
Macsalka, R1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Depth of Necrosis in Normal Cervical Epithelium After 85% Trichloroacetic Acid (TCA) Application[NCT04911075]40 participants (Actual)Interventional2021-04-15Completed
Nitrous Oxide as Treatment for Fibromyalgia[NCT05357066]Phase 250 participants (Anticipated)Interventional2021-11-12Recruiting
Nitrous Oxide as Treatment for Tinnitus: A Randomized Crossover Trial[NCT03365011]Phase 440 participants (Actual)Interventional2016-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Tinnitus Functional Index (TFI) Score

"Change of participant-reported tinnitus symptoms 1 week after each intervention.~The Tinnitus Functional Index (TFI) is a 25-question survey assessing tinnitus impact on quality of life. Participants were asked to rate on a scale from 0-10 the degree of unpleasantness, cognitive interference, sleep disturbance, auditory difficulties, interference with relaxation, and emotional distress associated with their tinnitus. Subscores are summed and scaled to a score of 0-100. A score less than 25 indicates mild problems due to tinnitus and little need for intervention, while a score between 25-50 indicates significant problems due to tinnitus with potential need for intervention.~A decrease in TFI score indicates decreased bother due to tinnitus over time, a better outcome. An increase in TFI score indicates increased bother due to tinnitus over time, a worse outcome." (NCT03365011)
Timeframe: Pre-intervention and 1 week post-intervention

Interventionscore on a scale (Mean)
Placebo-1.8
Nitrous Oxide-2.5

Change in Global Bothersome Scale (GBS) Score

"Change in participant-reported tinnitus bother after each intervention.~Global Bothersome Scale (GBS) measured participant's self-assessment of tinnitus bother on a 5-point scale ranging from Not bothered, 0 to Extremely bothered, 5.~A change of 0 indicates no change in tinnitus bother over time. A change of -1 indicates somewhat improved tinnitus bother, and a change of positive 1 indicates somewhat worsened tinnitus bother. A change of positive 2 indicates significantly worsened tinnitus bother." (NCT03365011)
Timeframe: Pre-intervention and 1 week post-intervention

,
Interventionparticipants (Number)
Somewhat improved, -1No change, 0Somewhat worsened, 1Significantly worsened, 2
Nitrous Oxide23420
Placebo52851

Trials

3 trials available for nitrous oxide and Necrosis

ArticleYear
Comparison of depth of necrosis using cryotherapy by gas and number of freeze cycles.
    Journal of lower genital tract disease, 2015, Volume: 19, Issue:1

    Topics: Adult; Carbon Dioxide; Cervix Uteri; Cryotherapy; Female; Gases; Humans; Middle Aged; Necrosis; Nitr

2015
Comparison of depth of necrosis achieved by CO2- and N2O-cryotherapy.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2008, Volume: 100, Issue:1

    Topics: Carbon Dioxide; Cervix Uteri; Conization; Cryotherapy; Female; Humans; Middle Aged; Necrosis; Nitrou

2008
Summary of the national Halothane Study. Possible association between halothane anesthesia and postoperative hepatic necrosis.
    JAMA, 1966, Sep-05, Volume: 197, Issue:10

    Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Barbiturates; Cyclopropanes; Ethers; Female; Haloth

1966

Other Studies

12 other studies available for nitrous oxide and Necrosis

ArticleYear
[Effectiveness of penis up transfer method for penoscrotal transposition in children].
    Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2022, Jun-15, Volume: 36, Issue:6

    Topics: Abnormalities, Multiple; Agriculture; Air Pollutants; Air Pollution; Child; Cicatrix; Humans; Hyperp

2022
Subdermal nitrous oxide delivery increases skin microcirculation and random flap survival in rats.
    Journal of plastic surgery and hand surgery, 2019, Volume: 53, Issue:1

    Topics: Angiography; Animals; Capillaries; Injections, Subcutaneous; Microcirculation; Necrosis; Nitrous Oxi

2019
Hepatic necrosis associated with herpesvirus after anesthesia with desflurane and nitrous oxide.
    Anesthesia and analgesia, 1994, Volume: 78, Issue:6

    Topics: Aged; Anesthesia, Inhalation; Anesthetics; Desflurane; Female; Hepatitis; Herpesviridae Infections;

1994
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin.
    Nature medicine, 1998, Volume: 4, Issue:4

    Topics: Animals; Brain; Cells, Cultured; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Hippocampus;

1998
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin.
    Nature medicine, 1998, Volume: 4, Issue:4

    Topics: Animals; Brain; Cells, Cultured; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Hippocampus;

1998
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin.
    Nature medicine, 1998, Volume: 4, Issue:4

    Topics: Animals; Brain; Cells, Cultured; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Hippocampus;

1998
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin.
    Nature medicine, 1998, Volume: 4, Issue:4

    Topics: Animals; Brain; Cells, Cultured; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Hippocampus;

1998
Cryosurgical treatment of hemangiomas of the lip.
    Oral surgery, oral medicine, and oral pathology, 1992, Volume: 73, Issue:6

    Topics: Adult; Aged; Cryosurgery; Female; Hemangioma; Humans; Lip; Lip Neoplasms; Male; Middle Aged; Necrosi

1992
Hepatic necrosis associated with herpes virus after isoflurane anesthesia.
    Anesthesia and analgesia, 1985, Volume: 64, Issue:11

    Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Herpesviridae Infections; Humans; I

1985
Fatal brain damage after dental anaesthesia. Its nature, etiology, and prevention.
    Lancet (London, England), 1966, Oct-22, Volume: 2, Issue:7469

    Topics: Adult; Anesthesia, Dental; Anesthesia, Inhalation; Brain Diseases; Halothane; Humans; Male; Methohex

1966
[Electron-microscopic findings in atria of guinea pigs after preservation in various gases and gas mixtures].
    Virchows Archiv. B, Cell pathology, 1972, Volume: 10, Issue:3

    Topics: Animals; Carbon Dioxide; Cell Membrane; Cell Nucleus; Cytoplasmic Granules; Gases; Glycogen; Guinea

1972
[Cerebral changes in 2 children after anesthesia incidents with long survival times].
    Beitrage zur gerichtlichen Medizin, 1973, Volume: 30

    Topics: Adolescent; Anesthesia; Brain; Brain Diseases; Cerebral Cortex; Child; Female; Humans; Male; Necrosi

1973
[Malignant hyperthermia during anesthesia].
    Arkhiv patologii, 1973, Volume: 35, Issue:11

    Topics: Adult; Anesthesia, Endotracheal; Animals; Autopsy; Brain Edema; Chick Embryo; Halothane; Hand; Heart

1973
Aseptic osteonecrosis: a study of tibial blood flow under various environmental conditions.
    Aerospace medicine, 1972, Volume: 43, Issue:7

    Topics: Air; Animals; Atmospheric Pressure; Blood Flow Velocity; Bone Diseases; Decompression Sickness; Dogs

1972
Destruction of the endometrium by cryosurgery.
    American journal of obstetrics and gynecology, 1971, Jun-15, Volume: 110, Issue:4

    Topics: Adult; Cryosurgery; Endometrium; Female; Humans; Hysterectomy; Methods; Necrosis; Nitrous Oxide; Pos

1971