DNA (cytosine-5)-methyltransferase 1

A DNA (cytosine-5)-methyltransferase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P26358]

Synonyms

Dnmt1;
EC 2.1.1.37;
CXXC-type zinc finger protein 9;
DNA methyltransferase HsaI;
DNA MTase HsaI;
M.HsaI;
MCMT

Research

Bioassay Publications (25)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (16.00)	29.6817
2010's	17 (68.00)	24.3611
2020's	4 (16.00)	2.80

Compounds (21)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
procainamide	Homo sapiens (human)	IC50	500.0000	1	1
vorinostat	Homo sapiens (human)	IC50	10.0000	1	1
dichlone	Homo sapiens (human)	IC50	1.6000	1	1
azacitidine	Homo sapiens (human)	IC50	0.3000	1	1
epigallocatechin gallate	Homo sapiens (human)	IC50	0.5000	1	1
5,5'-methylenedisalicylic acid	Homo sapiens (human)	IC50	69.5000	2	2
s-tubercidinylhomocysteine	Homo sapiens (human)	IC50	1.5000	1	1
s-adenosyl-3-thiopropylamine	Homo sapiens (human)	IC50	45.0000	1	1
n(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid	Homo sapiens (human)	IC50	302.0000	1	1
nsc 401077	Homo sapiens (human)	IC50	50.0000	1	1
s-adenosylhomocysteine	Homo sapiens (human)	IC50	1.4212	10	10
decitabine	Homo sapiens (human)	IC50	0.0300	1	1
rg108	Homo sapiens (human)	IC50	260.0383	3	3
genistein	Homo sapiens (human)	IC50	30.0000	1	1
psammaplin a	Homo sapiens (human)	IC50	0.0186	1	1
sgi-1027	Homo sapiens (human)	IC50	9.5900	8	8
bix 01294	Homo sapiens (human)	IC50	10.0000	2	2
unc 0638	Homo sapiens (human)	IC50	22.7188	5	5
gsk343	Homo sapiens (human)	IC50	100.0000	1	1
6,7-dimethoxy-2-(pyrrolidin-1-yl)-n-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	Homo sapiens (human)	IC50	100.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sgi-1027	Homo sapiens (human)	EC50	10.2000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
6-bromo-3-(bromomethyl)-7-methyl-2,3,7-trichloro-1-octene	Homo sapiens (human)	Activity	1.2500	1	1

Enables

This protein enables 8 target(s):

Target	Category	Definition
DNA binding	molecular function	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
DNA (cytosine-5-)-methyltransferase activity	molecular function	Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. [EC:2.1.1.37]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
methyl-CpG binding	molecular function	Binding to a methylated cytosine/guanine dinucleotide. [GOC:jl, PMID:11746232]
DNA-methyltransferase activity	molecular function	Catalysis of the transfer of a methyl group to a DNA molecule. [GOC:jl, ISBN:0198506732, PMID:7862522]
promoter-specific chromatin binding	molecular function	Binding to a section of chromatin that is associated with gene promoter sequences of DNA. [PMID:19948729]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
female germ cell nucleus	cellular component	The nucleus of the female germ cell, a reproductive cell in females. [CL:0000021, GOC:hjd]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
replication fork	cellular component	The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. [GOC:mah, ISBN:0198547684]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
pericentric heterochromatin	cellular component	Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3). [PMID:12019236, PMID:20206496, PMID:21437270, PMID:22729156, PMID:9413993]

Involved In

This protein is involved in 14 target(s):

Target	Category	Definition
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
DNA methylation-dependent heterochromatin formation	biological process	Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. [GOC:mah]
DNA-templated transcription	biological process	The synthesis of an RNA transcript from a DNA template. [GOC:jl, GOC:txnOH]
positive regulation of gene expression	biological process	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
negative regulation of gene expression	biological process	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
methylation	biological process	The process in which a methyl group is covalently attached to a molecule. [GOC:mah]
epigenetic programming of gene expression	biological process	A epigenetic process that happens during embryonic development that modulates gene expression potential at later stages of development of the organism, including the adult. Epigenetic regulation takes place via chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine DNA methylation. [GOC:go_curators, PMID:12138111, PMID:22868271]
negative regulation of gene expression via chromosomal CpG island methylation	biological process	An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide associated with the transcription start site of genes. [PMID:11898023, Wikipedia:Cpg_island]
cellular response to amino acid stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. [GOC:mah]
chromosomal DNA methylation maintenance following DNA replication	biological process	The process that maintains methylated cytosine in newly synthesized DNA following DNA replication. After the establishment of novel DNA methylation marks, the newly created patterns must be faithfully transmitted by maintenance DNA methyltransferases during cell division. [PMID:11005794, PMID:20142834, PMID:26077819, PMID:34968368]
cellular response to bisphenol A	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:22957036]
positive regulation of vascular associated smooth muscle cell proliferation	biological process	Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
negative regulation of vascular associated smooth muscle cell apoptotic process	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]