Proteins > Sigma intracellular receptor 2
Page last updated: 2024-08-07 20:40:25

Sigma intracellular receptor 2

A sigma intracellular receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5BJF2]

Synonyms

Sigma-2 receptor;
Sigma2 receptor;
Meningioma-associated protein 30;
Transmembrane protein 97

Research

Bioassay Publications (17)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's8 (47.06)24.3611
2020's9 (52.94)2.80

Compounds (27)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
astemizoleHomo sapiens (human)Ki0.095212
carbetapentaneHomo sapiens (human)Ki1.953011
chloroquineHomo sapiens (human)Ki0.501211
haloperidolHomo sapiens (human)Ki0.061666
hydroxychloroquineHomo sapiens (human)Ki1.000011
moclobemideHomo sapiens (human)Ki0.200011
nemonaprideHomo sapiens (human)Ki0.007211
1,3-ditolylguanidineHomo sapiens (human)Ki0.022133
4-toluic acidHomo sapiens (human)Ki10.000011
azaperoneHomo sapiens (human)Ki0.051112
clemastineHomo sapiens (human)Ki0.025111
befolHomo sapiens (human)Ki0.200011
adenosine-5'-carboxylic acidHomo sapiens (human)Ki0.796011
pentazocineHomo sapiens (human)Ki1.603333
cannabidiolHomo sapiens (human)Ki3.400011
pd 144418Homo sapiens (human)Ki0.794311
lu 28-179Homo sapiens (human)Ki0.000111
n-cyclopropyl adenosine-5'-carboxamideHomo sapiens (human)Ki4.350011
PB28Homo sapiens (human)Ki0.001422
pf 04457845Homo sapiens (human)Ki0.436720
e-52862Homo sapiens (human)Ki1.000011
skepinone-lHomo sapiens (human)Ki3.358010
wms 1410Homo sapiens (human)Ki0.010011
dolutegravirHomo sapiens (human)Ki0.018011
a-1155463Homo sapiens (human)Ki0.808420
MLI-2Homo sapiens (human)Ki4.590620

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
methyl-4-tyramineHomo sapiens (human)Kd6.600011

Enables

This protein enables 3 target(s):

TargetCategoryDefinition
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
oxysterol bindingmolecular functionBinding to oxysterol, an oxidized form of cholesterol. [GOC:curators]
cholesterol bindingmolecular functionBinding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:jl, ISBN:0198506732]

Located In

This protein is located in 6 target(s):

TargetCategoryDefinition
lysosomecellular componentA small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
endoplasmic reticulumcellular componentThe irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
rough endoplasmic reticulumcellular componentThe rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. [ISBN:0198506732]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
rough endoplasmic reticulum membranecellular componentThe lipid bilayer surrounding the rough endoplasmic reticulum. [GOC:mah]
nuclear membranecellular componentEither of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
endoplasmic reticulumcellular componentThe irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]

Involved In

This protein is involved in 6 target(s):

TargetCategoryDefinition
regulation of cell growthbiological processAny process that modulates the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
regulation of intracellular lipid transportbiological processAny process that modulates the frequency, rate or extent of the directed movement of lipids within cells. [GOC:mah]
regulation of intracellular cholesterol transportbiological processAny process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells. [GOC:mah]
cholesterol homeostasisbiological processAny process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators]
positive regulation of wound healingbiological processAny process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. [GOC:BHF]
positive regulation of lipoprotein transportbiological processAny process that activates or increases the rate or extent of lipoprotein transport. [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192]