Sigma intracellular receptor 2

A sigma intracellular receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5BJF2]

Synonyms

Sigma-2 receptor;
Sigma2 receptor;
Meningioma-associated protein 30;
Transmembrane protein 97

Research

Bioassay Publications (17)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	8 (47.06)	24.3611
2020's	9 (52.94)	2.80

Compounds (27)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
astemizole	Homo sapiens (human)	Ki	0.0952	1	2
carbetapentane	Homo sapiens (human)	Ki	1.9530	1	1
chloroquine	Homo sapiens (human)	Ki	0.5012	1	1
haloperidol	Homo sapiens (human)	Ki	0.0616	6	6
hydroxychloroquine	Homo sapiens (human)	Ki	1.0000	1	1
moclobemide	Homo sapiens (human)	Ki	0.2000	1	1
nemonapride	Homo sapiens (human)	Ki	0.0072	1	1
1,3-ditolylguanidine	Homo sapiens (human)	Ki	0.0221	3	3
4-toluic acid	Homo sapiens (human)	Ki	10.0000	1	1
azaperone	Homo sapiens (human)	Ki	0.0511	1	2
clemastine	Homo sapiens (human)	Ki	0.0251	1	1
befol	Homo sapiens (human)	Ki	0.2000	1	1
adenosine-5'-carboxylic acid	Homo sapiens (human)	Ki	0.7960	1	1
pentazocine	Homo sapiens (human)	Ki	1.6033	3	3
cannabidiol	Homo sapiens (human)	Ki	3.4000	1	1
pd 144418	Homo sapiens (human)	Ki	0.7943	1	1
lu 28-179	Homo sapiens (human)	Ki	0.0001	1	1
n-cyclopropyl adenosine-5'-carboxamide	Homo sapiens (human)	Ki	4.3500	1	1
PB28	Homo sapiens (human)	Ki	0.0014	2	2
pf 04457845	Homo sapiens (human)	Ki	0.4367	2	0
e-52862	Homo sapiens (human)	Ki	1.0000	1	1
skepinone-l	Homo sapiens (human)	Ki	3.3580	1	0
wms 1410	Homo sapiens (human)	Ki	0.0100	1	1
dolutegravir	Homo sapiens (human)	Ki	0.0180	1	1
a-1155463	Homo sapiens (human)	Ki	0.8084	2	0
MLI-2	Homo sapiens (human)	Ki	4.5906	2	0

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
methyl-4-tyramine	Homo sapiens (human)	Kd	6.6000	1	1

Enables

This protein enables 3 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
oxysterol binding	molecular function	Binding to oxysterol, an oxidized form of cholesterol. [GOC:curators]
cholesterol binding	molecular function	Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:jl, ISBN:0198506732]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
lysosome	cellular component	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
rough endoplasmic reticulum	cellular component	The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. [ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
rough endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the rough endoplasmic reticulum. [GOC:mah]
nuclear membrane	cellular component	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]

Involved In

This protein is involved in 6 target(s):

Target	Category	Definition
regulation of cell growth	biological process	Any process that modulates the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
regulation of intracellular lipid transport	biological process	Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells. [GOC:mah]
regulation of intracellular cholesterol transport	biological process	Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells. [GOC:mah]
cholesterol homeostasis	biological process	Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators]
positive regulation of wound healing	biological process	Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. [GOC:BHF]
positive regulation of lipoprotein transport	biological process	Any process that activates or increases the rate or extent of lipoprotein transport. [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192]

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