Proteins > Enoyl-[acyl-carrier-protein] reductase [NADH]
Page last updated: 2024-08-07 16:56:43
Enoyl-[acyl-carrier-protein] reductase [NADH]
[no definition available]
Synonyms
ENR;
Enoyl-ACP reductase;
EC 1.3.1.9;
FAS-II enoyl-ACP reductase;
NADH-dependent 2-trans-enoyl-ACP reductase
Research
Bioassay Publications (14)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 4 (28.57) | 2.80 |
Compounds (9)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| isoniazid | Mycobacterium tuberculosis H37Rv | IC50 | 8.2900 | 1 | 1 |
| triclosan | Mycobacterium tuberculosis H37Rv | IC50 | 2.8712 | 8 | 8 |
| triclosan | Mycobacterium tuberculosis H37Rv | Ki | 0.2100 | 4 | 4 |
| genz10850 | Mycobacterium tuberculosis H37Rv | IC50 | 0.1800 | 4 | 3 |
| epalrestat | Mycobacterium tuberculosis H37Rv | IC50 | 200.0000 | 1 | 1 |
| rifampin | Mycobacterium tuberculosis H37Rv | IC50 | 0.0300 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| pyrazinamide | Mycobacterium tuberculosis H37Rv | MIC | 25.3400 | 1 | 1 |
| ciprofloxacin | Mycobacterium tuberculosis H37Rv | MIC | 5.4850 | 2 | 2 |
| isoniazid | Mycobacterium tuberculosis H37Rv | MIC99 | 0.0700 | 1 | 1 |
| ethambutol | Mycobacterium tuberculosis H37Rv | MIC | 3.1250 | 1 | 1 |
| streptomycin | Mycobacterium tuberculosis H37Rv | MIC | 11.7400 | 1 | 1 |
The bioisosteric modification of pyrazinamide derivatives led to potent antitubercular agents: Synthesis via click approach and molecular docking of pyrazine-1,2,3-triazoles.Bioorganic & medicinal chemistry letters, , 01-15, Volume: 30, Issue:2, 2020
Design and synthesis of new indanol-1,2,3-triazole derivatives as potent antitubercular and antimicrobial agents.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 30, Issue:22, 2020
Design and synthesis of 4-Aminoquinoline-isoindoline-dione-isoniazid triads as potential anti-mycobacterials.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 30, Issue:22, 2020
Discovery and development of novel rhodanine derivatives targeting enoyl-acyl carrier protein reductase.Bioorganic & medicinal chemistry, , 04-15, Volume: 27, Issue:8, 2019
Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents.RSC medicinal chemistry, , Jan-01, Volume: 12, Issue:1, 2021
Discovery and development of novel rhodanine derivatives targeting enoyl-acyl carrier protein reductase.Bioorganic & medicinal chemistry, , 04-15, Volume: 27, Issue:8, 2019
Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold.Bioorganic & medicinal chemistry letters, , 06-15, Volume: 28, Issue:11, 2018
An overview on crystal structures of InhA protein: Apo-form, in complex with its natural ligands and inhibitors.European journal of medicinal chemistry, , Feb-25, Volume: 146, 2018
2-Phenylindole and Arylsulphonamide: Novel Scaffolds Bactericidal against Mycobacterium tuberculosis.ACS medicinal chemistry letters, , Sep-11, Volume: 5, Issue:9, 2014
Methyl-thiazoles: a novel mode of inhibition with the potential to develop novel inhibitors targeting InhA in Mycobacterium tuberculosis.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors.Bioorganic & medicinal chemistry letters, , May-15, Volume: 18, Issue:10, 2008
High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis.ACS chemical biology, , Feb-17, Volume: 1, Issue:1, 2006
Agonodepsides a and B: two new depsides from a filamentous fungus F7524.Journal of natural products, , Volume: 65, Issue:7, 2002
An overview on crystal structures of InhA protein: Apo-form, in complex with its natural ligands and inhibitors.European journal of medicinal chemistry, , Feb-25, Volume: 146, 2018
Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides.Bioorganic & medicinal chemistry, , Nov-01, Volume: 15, Issue:21, 2007
[no title available],