| Assay ID | Title | Year | Journal | Article |
|---|
| AID426145 | Antituberculosis activity against Mycobacterium tuberculosis H37Rv assessed as parasite growth inhibition at 25 ug/ml after 4 days by microplate alamar blue assay | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7
| Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. |
| AID734082 | Selectivity index, ratio of CC50 for human HepG2 cells to IC50 for chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID426150 | Antibacterial activity against Salmonella Typhimurium MS 7953 by radial diffusion assay | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7
| Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. |
| AID357845 | Binding affinity to calf thymus DNA assessed as reduction in DNA peak by pre-incubation method | | | |
| AID669309 | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as gated cells in upper right quadrant at 400 uM after 3 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 1.40%) | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID707336 | Antiinflammatory activity in complete Freund's adjuvant-induced Swiss mouse pain model assessed as inhibition of paw flinching at 10 mg/kg, po administered 30 mins prior to challenge | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID357846 | Binding affinity to yeast tRNA assessed as reduction in tRNA peak by pre-incubation method | | | |
| AID707334 | Antihyperalgesic activity in po dosed carrageenan-induced mechanical hyperalgesia Swiss mouse model assessed as paw withdrawal latency administered 30 mins prior to challenge by electronic pressure-meter test | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID336447 | Antiplatelet activity against washed rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation at 200 uM | 2002 | Journal of natural products, Oct, Volume: 65, Issue:10
| New ent-kaurane diterpenoids with anti-platelet aggregation activity from Annona squamosa. |
| AID1683372 | Antischistosomal activity against male Schistosoma mansoni BH assessed as dilation of testes at 25 uM after 72 hrs microscopic method | | | |
| AID707134 | Antiinflammatory activity in Swiss mouse model assessed as inhibition of carrageenan-induced IL-1beta production in cutaneous plantar tissue at 10 mg/kg, po administered 30 mins prior to challenge measured 3 hrs post challenge by ELISA | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID707135 | Antiinflammatory activity in Swiss mouse model assessed as inhibition of carrageenan-induced TNFalpha production in cutaneous plantar tissue at 10 mg/kg, po administered 30 mins prior to challenge measured 3 hrs post challenge by ELISA | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID669314 | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as gated cells in upper left quadrant at 400 uM after 3 hrs by rhodamine 123 staining-based flow cytometric analysis (Rvb = 1.54%) | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID426147 | Antibacterial activity against Enterococcus faecalis ATCC 29212 by radial diffusion assay | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7
| Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. |
| AID707126 | Antihyperalgesic activity in carrageenan-induced mechanical hyperalgesia Swiss mouse model assessed as paw withdrawal latency at 10 mg/kg, po administered 30 mins prior to challenge measured after 1 to 5 hrs post challenge by electronic pressure-meter tes | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID1169836 | Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-1beta expression pretreated 1 hr before LPS challenge followed by incubated for 16 hrs by flow cytometry | 2014 | Journal of natural products, Nov-26, Volume: 77, Issue:11
| Anti-inflammatory diterpenoids from the root bark of Acanthopanax gracilistylus. |
| AID707123 | Antihyperalgesic activity against thermal hyperalgesia in Swiss mouse assessed as increase in thermal nociceptive threshold at 10 mg/kg, po after 1.5 to 5.5 hrs by hot plate test | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID707338 | Antinociceptive activity against formalin-induced pain in Swiss mouse assessed as inhibition of paw flinching at 10 mg/kg, po administered 30 mins prior to formalin challenge | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID758685 | Inhibition of human 11beta-HSD1 expressed in HEK293 cell microsomes assessed as inhibition of [3H]cortisone conversion to [3H]cortisol at 1 uM by scintillation proximity assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: potential impact in diabetes. |
| AID1683379 | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 48 hrs by MTT assay | | | |
| AID734086 | Growth inhibition against human IGROV cells after 72 hrs by inverted microscopy | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID1417119 | Antileishmanial activity against Leishmania amazonensis WHOM/BR/75/Josefa promastigotes after 72 hrs by Neubauer chamber method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase. |
| AID707343 | Antinociceptive activity in Swiss mouse assessed as inhibition of acetic acid-induced writhing at 3 to 30 mg/kg, ip administered 30 mins prior to acetic acid challenge | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID707133 | Antihyperalgesic activity in PGE2-induced mechanical hyperalgesia Swiss mouse model assessed as paw withdrawal latency at 10 mg/kg, po administered 30 mins prior to challenge measured at 3 hrs post compound treatment by electronic pressure-meter test | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID758688 | Inhibition of human 11beta-HSD1 expressed in HEK293 cell microsomes assessed as inhibition of [3H]cortisone conversion to [3H]cortisol by scintillation proximity assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: potential impact in diabetes. |
| AID707337 | Antinociceptive activity against formalin-induced pain in Swiss mouse assessed as inhibition of paw licking at 10 mg/kg, po administered 30 mins prior to formalin challenge | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID669300 | Cytotoxicity against monkey LLC-MK2 cells after 96 hrs by sulforhodamine B assay | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID354581 | Toxicity against brine shrimp | 1996 | Journal of natural products, Mar, Volume: 59, Issue:3
| Bioactive ent-kaurene diterpenoids from Annona senegalensis. |
| AID1417094 | Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured after 60 secs | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase. |
| AID1683377 | Cytotoxicity against human HaCaT cells assessed as reduction in cell viability after 48 hrs by MTT assay | | | |
| AID707117 | Gastrointestinal toxicity in Swiss mouse assessed as increase in stomach MPO activity at at 10 mg/kg, po for 7 days measured over 7 days relative to vehicle-treated control | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID734088 | Growth inhibition against human K562 cells after 72 hrs by inverted microscopy | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID1683371 | Antischistosomal activity against female Schistosoma mansoni BH assessed as dilation of ovaries at 25 uM after 72 hrs microscopic method | | | |
| AID284140 | Induction of total haemolysis in Albino mouse blood infected with Trypanosoma cruzi Y at 5 mM | 2007 | Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
| Synthesis and trypanocidal activity of ent-kaurane glycosides. |
| AID669307 | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as gated cells in lower left quadrant at 400 uM after 3 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 89.35%) | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID426151 | Antibacterial activity against Salmonella Typhimurium EG10627 by radial diffusion assay | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7
| Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. |
| AID707335 | Antiinflammatory activity in complete Freund's adjuvant-induced Swiss mouse pain model assessed as inhibition of paw licking at 10 mg/kg, po administered 30 mins prior to challenge | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID758687 | selectivity ratio of IC50 for human 11beta-HSD2 to IC50 for human 11beta-HSD1 | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: potential impact in diabetes. |
| AID669299 | Antitrypanosomal activity against Trypanosoma cruzi Y amastigotes infected in monkey LLC-MK2 cells after 96 hrs by Geimsa staining method | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID707121 | Hepatotoxicity in Swiss mouse assessed as change in plasma AST level at 10 mg/kg, po for 7 days measured over 7 days relative to vehicle-treated control | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID354583 | Cytotoxicity against human MCF7 cells after 7 days by MTT assay | 1996 | Journal of natural products, Mar, Volume: 59, Issue:3
| Bioactive ent-kaurene diterpenoids from Annona senegalensis. |
| AID758689 | Inhibition of mouse 11beta-HSD1 expressed in HEK293 cell microsomes assessed as inhibition of [3H]cortisone conversion to [3H]cortisol by scintillation proximity assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: potential impact in diabetes. |
| AID1169837 | Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-8 expression pretreated 1 hr before LPS challenge followed by incubated for 16 hrs by flow cytometry | 2014 | Journal of natural products, Nov-26, Volume: 77, Issue:11
| Anti-inflammatory diterpenoids from the root bark of Acanthopanax gracilistylus. |
| AID707127 | Antihyperalgesic activity in carrageenan-induced mechanical hyperalgesia Swiss mouse model assessed as paw withdrawal latency at 10 mg/kg, po administered 30 mins prior to challenge measured after 1 to 5 hrs post challenge by electronic pressure-meter tes | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID1684121 | Inhibition of NF-kappaB activation in mouse RaW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs by Griess reagent based assay | 2020 | Journal of natural products, 12-24, Volume: 83, Issue:12
| 3α-Angeloyloxy- |
| AID758684 | Inhibition of mouse 11beta-HSD1 expressed in HEK293 cell microsomes assessed as inhibition of [3H]cortisone conversion to [3H]cortisol at 1 uM by scintillation proximity assay | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: potential impact in diabetes. |
| AID669296 | Antitrypanosomal activity against Trypanosoma cruzi Y infected in monkey LLC-MK2 cells assessed as reduction in number of amastigotes after 96 hrs by Geimsa staining method | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID589274 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release pretreated for 15 mins before LPS challenge measured after 24 hrs by Griess method | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4
| Synthesis and anti-inflammatory activity of ent-kaurene derivatives. |
| AID734081 | Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID284134 | Trypanocidal activity against Trypanosoma cruzi Y blood stream trypomastigotes assessed as parasite lysis at 2.50 mM relative to control | 2007 | Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
| Synthesis and trypanocidal activity of ent-kaurane glycosides. |
| AID669301 | Toxicity in human RBC assessed as hemolysis after 3 hrs | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID707138 | Antihyperalgesic activity in complete Freund's adjuvant-induced Swiss mouse pain model assessed as paw withdrawal latency at 10 mg/kg, po starting 1 hr post challenge for 7 days measured after 2 to 7 days by electronic pressure-meter test | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID758690 | Inhibition of mouse 11beta-HSD2 | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: potential impact in diabetes. |
| AID707331 | Antihyperalgesic activity in carrageenan-induced mechanical hyperalgesia Swiss mouse model assessed as paw withdrawal latency at 10 mg/kg, po administered 30 mins prior to challenge measured after 1 to 5 hrs post stimulus by electronic pressure-meter test | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID426149 | Antibacterial activity against Salmonella Typhimurium ATCC 14028s by radial diffusion assay | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7
| Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. |
| AID707332 | Antihyperalgesic activity in carrageenan-induced mechanical hyperalgesia Swiss mouse model assessed as paw withdrawal latency at 3 mg/kg, po administered 30 mins prior to challenge measured after 1 to 3 hrs post stimulus by electronic pressure-meter test | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID734084 | Growth inhibition against human LoVo cells after 72 hrs by inverted microscopy | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID1103177 | Antifungal activity against Botryotinia fuckeliana inoculated in tomato leaf assessed as reduction in lesion area at 40 ug/ml after 4 days (Rvb =9.7 +/- 1.8 mm2 ) | 2004 | Journal of agricultural and food chemistry, May-19, Volume: 52, Issue:10
| Characterization of the antifungal activity on Botrytis cinerea of the natural diterpenoids kaurenoic acid and 3beta-hydroxy-kaurenoic acid. |
| AID707333 | Antihyperalgesic activity in carrageenan-induced mechanical hyperalgesia Swiss mouse model assessed as paw withdrawal latency at 1 mg/kg, po administered 30 mins prior to challenge by electronic pressure-meter test | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID336450 | Antiplatelet activity against washed rabbit platelet assessed as inhibition of thrombin-induced platelet aggregation at 200 uM | 2002 | Journal of natural products, Oct, Volume: 65, Issue:10
| New ent-kaurane diterpenoids with anti-platelet aggregation activity from Annona squamosa. |
| AID1103182 | Antifungal activity against Botryotinia fuckeliana assessed as inhibition of mycelial growth at 40 to 160 ug/ml up to 7 days | 2004 | Journal of agricultural and food chemistry, May-19, Volume: 52, Issue:10
| Characterization of the antifungal activity on Botrytis cinerea of the natural diterpenoids kaurenoic acid and 3beta-hydroxy-kaurenoic acid. |
| AID1417120 | Antileishmanial activity against Leishmania amazonensis WHOM/BR/75/Josefa amastigotes after 72 hrs by Neubauer chamber method | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase. |
| AID354587 | Cytotoxicity against human MIAPaCa2 cells after 7 days by MTT assay | 1996 | Journal of natural products, Mar, Volume: 59, Issue:3
| Bioactive ent-kaurene diterpenoids from Annona senegalensis. |
| AID669311 | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as gated cells in lower left quadrant at 400 uM after 3 hrs by rhodamine 123 staining-based flow cytometric analysis (Rvb = 2.40%) | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID1683381 | Antischistosomal activity against Schistosoma mansoni BH assessed as reduction in parasitic viability inverted light microscopic method | | | |
| AID669298 | Antitrypanosomal activity against Trypanosoma cruzi Y trymastigotes infected in monkey LLC-MK2 cells after 24 hrs by Brenner counter method | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID758691 | Selectivity ratio of IC50 for mouse 11beta-HSD2 to IC50 for mouse 11beta-HSD1 | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: potential impact in diabetes. |
| AID1103180 | Antifungal activity against Botryotinia fuckeliana assessed as reduction in mycelial growth rate at 40 to 160 ug/ml up to 9 days (Rvb = 1.82 cm/day) | 2004 | Journal of agricultural and food chemistry, May-19, Volume: 52, Issue:10
| Characterization of the antifungal activity on Botrytis cinerea of the natural diterpenoids kaurenoic acid and 3beta-hydroxy-kaurenoic acid. |
| AID707342 | Antinociceptive activity in po dosed Swiss mouse assessed as inhibition of acetic acid-induced writhing administered 30 mins prior to acetic acid challenge | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID284138 | Induction of total haemolysis in Albino mouse blood infected with Trypanosoma cruzi Y at 1.25 mM | 2007 | Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
| Synthesis and trypanocidal activity of ent-kaurane glycosides. |
| AID1181215 | Cytotoxicity against human K562 cells after 72 hrs by alamar blue assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation. |
| AID669313 | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as gated cells in upper right quadrant at 400 uM after 3 hrs by rhodamine 123 staining-based flow cytometric analysis (Rvb = 94.94%) | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID266456 | Inhibition of human recombinant PTP1B | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum. |
| AID354585 | Cytotoxicity against human A498 cells after 7 days by MTT assay | 1996 | Journal of natural products, Mar, Volume: 59, Issue:3
| Bioactive ent-kaurene diterpenoids from Annona senegalensis. |
| AID669302 | Selectivity ratio of CC50 for monkey LLC-MK2 cells to IC50 for Trypanosoma cruzi Y amastigotes | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID707341 | Antinociceptive activity in Swiss mouse assessed as inhibition of PBQ-induced writhing at 10 mg/kg, po administered 30 mins prior to PBQ challenge | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID1103176 | Antifungal activity against Botryotinia fuckeliana grown assessed as membrane leakage measuring efflux of phosphorus at 100 ug/ml after 6 hr by ICP-OES analysis | 2004 | Journal of agricultural and food chemistry, May-19, Volume: 52, Issue:10
| Characterization of the antifungal activity on Botrytis cinerea of the natural diterpenoids kaurenoic acid and 3beta-hydroxy-kaurenoic acid. |
| AID1103173 | Antifungal activity against Botryotinia fuckeliana grown assessed as induction of production of p-nitrophenyl butyrate esterase after 20 days relative to control | 2004 | Journal of agricultural and food chemistry, May-19, Volume: 52, Issue:10
| Characterization of the antifungal activity on Botrytis cinerea of the natural diterpenoids kaurenoic acid and 3beta-hydroxy-kaurenoic acid. |
| AID734495 | Growth inhibition against human LoVo/DX cells after 72 hrs by inverted microscopy | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID1683380 | Selectivity index, ratio of CC50 for cytotoxicity against human SH-SY5Y cells to LC50 for antischistosomal activity against Schistosoma mansoni BH | | | |
| AID734085 | Growth inhibition against human HeLa cells after 72 hrs by inverted microscopy | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID1181216 | Cytotoxicity against concanavalin-A stimulated human PBMC after 72 hrs by alamar blue assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation. |
| AID376818 | Inhibition of HIV reverse transcriptase at 33 ug/mL by scintillation counting | 1998 | Journal of natural products, Apr, Volume: 61, Issue:4
| Bioactive kaurane diterpenoids from Annona glabra. |
| AID734087 | Growth inhibition against human IGROV-ET cells after 72 hrs by inverted microscopy | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID426146 | Antibacterial activity against Staphylococcus aureus ATCC 65380 by radial diffusion assay | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7
| Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. |
| AID1169838 | Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha expression pretreated 1 hr before LPS challenge followed by incubated for 16 hrs by flow cytometry | 2014 | Journal of natural products, Nov-26, Volume: 77, Issue:11
| Anti-inflammatory diterpenoids from the root bark of Acanthopanax gracilistylus. |
| AID336448 | Antiplatelet activity against washed rabbit platelet assessed as inhibition of collagen-induced platelet aggregation at 200 uM | 2002 | Journal of natural products, Oct, Volume: 65, Issue:10
| New ent-kaurane diterpenoids with anti-platelet aggregation activity from Annona squamosa. |
| AID354584 | Cytotoxicity against human HT29 cells after 7 days by MTT assay | 1996 | Journal of natural products, Mar, Volume: 59, Issue:3
| Bioactive ent-kaurene diterpenoids from Annona senegalensis. |
| AID1181212 | Cytotoxicity against mouse B16F10 cells after 72 hrs by alamar blue assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation. |
| AID669312 | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as gated cells in lower right quadrant at 400 uM after 3 hrs by rhodamine 123 staining-based flow cytometric analysis (Rvb = 1.12%) | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID669310 | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as gated cells in upper left quadrant at 400 uM after 3 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 3.76%) | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID1683375 | Antischistosomal activity against Schistosoma mansoni BH assessed as reduction in parasitic viability at 25 uM after 24 hrs inverted light microscopic method | | | |
| AID707124 | Toxicity in Swiss mouse assessed as effect on muscle-relaxing effect at 10 mg/kg, po after 1.5 to 5.5 hrs by roto-rod test | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID354586 | Cytotoxicity against human PC3 cells after 7 days by MTT assay | 1996 | Journal of natural products, Mar, Volume: 59, Issue:3
| Bioactive ent-kaurene diterpenoids from Annona senegalensis. |
| AID336449 | Antiplatelet activity against washed rabbit platelet assessed as inhibition of platelet activating factor-induced platelet aggregation at 200 uM | 2002 | Journal of natural products, Oct, Volume: 65, Issue:10
| New ent-kaurane diterpenoids with anti-platelet aggregation activity from Annona squamosa. |
| AID284135 | Trypanocidal activity against blood stream Trypanosoma cruzi Y trypomastigotes assessed as parasite lysis at 5 mM relative to control | 2007 | Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
| Synthesis and trypanocidal activity of ent-kaurane glycosides. |
| AID1683378 | Selectivity index, ratio of CC50 for cytotoxicity against human HaCaT cells to LC50 for antischistosomal activity against Schistosoma mansoni BH | | | |
| AID707132 | Antihyperalgesic activity in carrageenan-induced mechanical hyperalgesia Swiss mouse model assessed as paw withdrawal latency at 10 mg/kg, po administered 30 mins prior to challenge measured after 1 to 5 hrs post challenge by electronic pressure-meter tes | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID707136 | Antihyperalgesic activity in complete Freund's adjuvant-induced Swiss mouse pain model assessed as paw withdrawal latency at 5 mg/kg, ip starting 1 hr post challenge for 7 days measured after 2 to 7 days by electronic pressure-meter test | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID1181214 | Cytotoxicity against human HL60 cells after 72 hrs by alamar blue assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation. |
| AID1417091 | Inhibition of human DHODH at 100 uM | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase. |
| AID734083 | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of parasite growth after 24 hrs by [3H]hypoxanthine incorporation assay | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID707131 | Antihyperalgesic activity in carrageenan-induced mechanical hyperalgesia Swiss mouse model assessed as paw withdrawal latency at 10 mg/kg, po administered 30 mins prior to challenge measured after 1 to 5 hrs post challenge by electronic pressure-meter tes | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID284132 | Trypanocidal activity against Trypanosoma cruzi Y blood stream trypomastigotes assessed as parasite lysis at 0.63 mM relative to control | 2007 | Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
| Synthesis and trypanocidal activity of ent-kaurane glycosides. |
| AID1417093 | Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells at 100 uM using DHO as substrate measured after 60 secs | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase. |
| AID426074 | Antituberculosis activity against Mycobacterium tuberculosis H37Rv assessed as parasite growth inhibition at 100 ug/ml after 4 days by microplate alamar blue assay | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7
| Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. |
| AID707137 | Antihyperalgesic activity in complete Freund's adjuvant-induced Swiss mouse pain model assessed as paw withdrawal latency at 10 mg/kg, po starting 1 hr post challenge for 7 days measured on day 1 post challenge by electronic pressure-meter test | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID734089 | Growth inhibition against human PANC1 cells after 72 hrs by inverted microscopy | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID707128 | Antihyperalgesic activity in carrageenan-induced mechanical hyperalgesia Swiss mouse model assessed as paw withdrawal latency at 10 mg/kg, po administered 30 mins prior to challenge measured after 1 to 5 hrs post challenge by electronic pressure-meter tes | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID1181213 | Cytotoxicity against human HepG2 cells after 72 hrs by alamar blue assay | 2014 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
| ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation. |
| AID284133 | Trypanocidal activity against Trypanosoma cruzi Y blood stream trypomastigotes assessed as parasite lysis at 1.25 mM relative to control | 2007 | Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
| Synthesis and trypanocidal activity of ent-kaurane glycosides. |
| AID669308 | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as gated cells in lower right quadrant at 400 uM after 3 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 5.41%) | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID426075 | Antituberculosis activity against Mycobacterium tuberculosis H37Rv assessed as parasite growth inhibition at 50 ug/ml after 4 days by microplate alamar blue assay | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7
| Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. |
| AID707125 | Toxicity in Swiss mouse assessed as sedative effect at 10 mg/kg, po after 1.5 to 5.5 hrs by roto-rod test | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID1683376 | Antischistosomal activity against Schistosoma mansoni BH assessed as reduction in parasitic viability after 72 hrs by inverted microscopic method | | | |
| AID1683373 | Antischistosomal activity against Schistosoma mansoni BH assessed as reduction in oviposition at 25 uM after 72 hrs light microscopic method | | | |
| AID669297 | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes after 96 hrs by neubauer chamber | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID458882 | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Synthesis and induction of apoptosis signaling pathway of ent-kaurane derivatives. |
| AID707130 | Antihyperalgesic activity in carrageenan-induced mechanical hyperalgesia Swiss mouse model assessed as paw withdrawal latency at 10 mg/kg, po administered 30 mins prior to challenge measured after 1 to 5 hrs post challenge by electronic pressure-meter tes | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID354582 | Cytotoxicity against human A549 cells after 7 days by MTT assay | 1996 | Journal of natural products, Mar, Volume: 59, Issue:3
| Bioactive ent-kaurene diterpenoids from Annona senegalensis. |
| AID758686 | Inhibition of human 11beta-HSD2 | 2013 | European journal of medicinal chemistry, Jul, Volume: 65 | Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: potential impact in diabetes. |
| AID1103179 | Antifungal activity against Botryotinia fuckeliana grown in malt-yeast extract medium assessed as inhibition of mycelial growth at 40 to 160 ug/ml | 2004 | Journal of agricultural and food chemistry, May-19, Volume: 52, Issue:10
| Characterization of the antifungal activity on Botrytis cinerea of the natural diterpenoids kaurenoic acid and 3beta-hydroxy-kaurenoic acid. |
| AID1103172 | Antifungal activity against Botryotinia fuckeliana grown assessed as induction of production of laccase after 10 days relative to control | 2004 | Journal of agricultural and food chemistry, May-19, Volume: 52, Issue:10
| Characterization of the antifungal activity on Botrytis cinerea of the natural diterpenoids kaurenoic acid and 3beta-hydroxy-kaurenoic acid. |
| AID669306 | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as lipid peroxidation at 400 uM after 6 hrs | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
| Terpenes from Copaifera demonstrated in vitro antiparasitic and synergic activity. |
| AID426148 | Antibacterial activity against Escherichia coli ATCC 25922 by radial diffusion assay | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7
| Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. |
| AID707129 | Antihyperalgesic activity in carrageenan-induced mechanical hyperalgesia Swiss mouse model assessed as paw withdrawal latency at 10 mg/kg, po administered 30 mins prior to challenge measured after 1 to 5 hrs post challenge by electronic pressure-meter tes | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID284131 | Trypanocidal activity against Trypanosoma cruzi Y blood stream trypomastigotes assessed as parasite lysis at 0.31 mM relative to control | 2007 | Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
| Synthesis and trypanocidal activity of ent-kaurane glycosides. |
| AID1103183 | Antifungal activity against Botryotinia fuckeliana assessed as inhibition of mycelial growth at 40 to 160 ug/ml up to 6 days | 2004 | Journal of agricultural and food chemistry, May-19, Volume: 52, Issue:10
| Characterization of the antifungal activity on Botrytis cinerea of the natural diterpenoids kaurenoic acid and 3beta-hydroxy-kaurenoic acid. |
| AID734494 | Growth inhibition against human HT-29 cells after 72 hrs by inverted microscopy | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives. |
| AID284139 | Induction of total haemolysis in Albino mouse blood infected with Trypanosoma cruzi Y at 2.5 mM | 2007 | Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
| Synthesis and trypanocidal activity of ent-kaurane glycosides. |
| AID589275 | Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell viability at 1 to 25 uM pretreated for 15 mins before LPS challenge measured after 24 hrs by MTT assay | 2011 | European journal of medicinal chemistry, Apr, Volume: 46, Issue:4
| Synthesis and anti-inflammatory activity of ent-kaurene derivatives. |
| AID355092 | Antiviral activity against HIV1 3B replication in human H9 cells up to 100 ug/mL after 3 days by p24 antigen capture assay | 1996 | Journal of natural products, Jun, Volume: 59, Issue:6
| Identification of ent-16 beta, 17-dihydroxykauran-19-oic acid as an anti-HIV principle and isolation of the new diterpenoids annosquamosins A and B from Annona squamosa. |
| AID707120 | Hepatotoxicity in Swiss mouse assessed as change in plasma ALT level at 10 mg/kg, po for 7 days measured over 7 days relative to vehicle-treated control | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID707115 | Antihyperalgesic activity in complete Freund's adjuvant-induced Swiss mouse pain model assessed as paw withdrawal latency at 5 mg/kg, ip starting 1 hr post challenge for 7 days measured on day 1 post challenge by electronic pressure-meter test | 2012 | Journal of natural products, May-25, Volume: 75, Issue:5
| Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. |
| AID1447311 | Induction of apoptosis in human SMMC7721 cells assessed as late apoptotic cells at IC50 after 24 hrs by annexin V/PI-staining based flow cytometry (Rvb = 0.5 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447310 | Induction of apoptosis in human SMMC7721 cells assessed as early apoptotic cells at IC50 after 24 hrs by annexin V/PI-staining based flow cytometry (Rvb = 0.6 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447327 | Cell cycle arrest in human SMMC7721 cells assessed as G1 phase accumulation at half IC50 after 24 hrs by propidium iodide-staining based flow cytometry (Rvb = 57.6 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447319 | Induction of apoptosis in human SMMC7721 cells assessed as increase in cleaved caspase 9 levels after 24 hrs by Western blot method | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447325 | Induction of apoptosis in human SMMC7721 cells assessed as necrotic cells at half IC50 after 24 hrs by annexin V/PI-staining based flow cytometry (Rvb =1.6 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447323 | Induction of apoptosis in human SMMC7721 cells assessed as early apoptotic cells at half IC50 after 24 hrs by annexin V/PI-staining based flow cytometry (Rvb = 0.6 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447312 | Induction of apoptosis in human SMMC7721 cells assessed as necrotic cells at IC50 after 24 hrs by annexin V/PI-staining based flow cytometry (Rvb =1.6 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447320 | Induction of apoptosis in human SMMC7721 cells assessed as increase in Bax levels after 24 hrs by Western blot method | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447329 | Cell cycle arrest in human SMMC7721 cells assessed as G2/M phase accumulation at half IC50 after 24 hrs by propidium iodide-staining based flow cytometry (Rvb = 28.8 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447324 | Induction of apoptosis in human SMMC7721 cells assessed as late apoptotic cells at half IC50 after 24 hrs by annexin V/PI-staining based flow cytometry (Rvb = 0.5 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447315 | Cell cycle arrest in human SMMC7721 cells assessed as S phase accumulation at IC50 after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 12.7 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447316 | Cell cycle arrest in human SMMC7721 cells assessed as G2/M phase accumulation at IC50 after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 28.8 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447328 | Cell cycle arrest in human SMMC7721 cells assessed as S phase accumulation at half IC50 after 24 hrs by propidium iodide-staining based flow cytometry (Rvb = 12.7 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447313 | Cell cycle arrest in human SMMC7721 cells assessed as sub-G1 phase accumulation at IC50 after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 0.8 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447317 | Induction of apoptosis in human SMMC7721 cells assessed as increase in cleaved caspase 3 levels after 24 hrs by Western blot method | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447318 | Induction of apoptosis in human SMMC7721 cells assessed as increase in cleaved caspase 8 levels after 24 hrs by Western blot method | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447322 | Induction of apoptosis in human SMMC7721 cells assessed as live cells at half IC50 after 24 hrs by annexin V/PI-staining based flow cytometry (Rvb = 97.3 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447321 | Induction of apoptosis in human SMMC7721 cells assessed as decrease in Bcl2 levels after 24 hrs by Western blot method | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447314 | Cell cycle arrest in human SMMC7721 cells assessed as G1 phase accumulation at IC50 after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 57.6 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447332 | Induction of apoptosis in human SMMC7721 cells assessed as broken nuclei after 24 hrs by Hoechst 33258 staining based fluorescent microscopic method | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447308 | Induction of apoptosis in human SMMC7721 cells assessed as live cells at IC50 after 24 hrs by annexin V/PI-staining based flow cytometry (Rvb = 97.3 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447330 | Induction of apoptosis in human SMMC7721 cells after 24 hrs by annexin V/PI-staining based flow cytometry | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447326 | Cell cycle arrest in human SMMC7721 cells assessed as sub-G1 phase accumulation at half IC50 after 24 hrs by propidium iodide-staining based flow cytometry (Rvb = 0.8 %) | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447331 | Induction of apoptosis in human SMMC7721 cells assessed as condensed nuclei after 24 hrs by Hoechst 33258 staining based fluorescent microscopic method | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| AID1447309 | Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |