Page last updated: 2024-08-07 16:47:04
D(1A) dopamine receptor
A D(1A) dopamine receptor that is encoded in the genome of pig. [OMA:P50130, PRO:DNx]
Synonyms
Dopamine D1 receptor
Research
Bioassay Publications (12)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
Compounds (154)
Drugs with Potency Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| quinacrine | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| catechol | Sus scrofa (pig) | Potency | 0.9268 | 1 | 0 |
| sk&f 82958 | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| octoclothepine | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| 1,10-phenanthroline | Sus scrofa (pig) | Potency | 0.0465 | 1 | 0 |
| 3,4-dichloroisocoumarin | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| 6-nitroso-1,2-benzopyrone | Sus scrofa (pig) | Potency | 5.2119 | 1 | 0 |
| N-(2-aminoethyl)-5-chloro-1-naphthalenesulfonamide | Sus scrofa (pig) | Potency | 16.4816 | 1 | 0 |
| aa 861 | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| amiodarone | Sus scrofa (pig) | Potency | 13.0918 | 1 | 0 |
| amitriptyline | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| amoxapine | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| amsacrine | Sus scrofa (pig) | Potency | 3.6898 | 1 | 0 |
| aprindine | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| benserazide | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| calmidazolium | Sus scrofa (pig) | Potency | 16.4816 | 1 | 0 |
| cantharidin | Sus scrofa (pig) | Potency | 4.6451 | 1 | 0 |
| carvedilol | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| cgs 15943 | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| chlorpromazine | Sus scrofa (pig) | Potency | 16.4816 | 1 | 0 |
| clemastine | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| clomipramine | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| cyclobenzaprine | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| dequalinium | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| desipramine | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| diphenyleneiodonium | Sus scrofa (pig) | Potency | 0.0585 | 1 | 0 |
| 2,3-dimethoxy-1,4-naphthoquinone | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| doxazosin | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| ebastine | Sus scrofa (pig) | Potency | 4.6451 | 1 | 0 |
| fluphenazine | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| fluoxetine | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| fluspirilene | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| vanoxerine | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| gbr 12935 | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| gossypol | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| 1-(5-isoquinolinesulfonyl)-2-methylpiperazine | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| haloperidol | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| 4-fluorohexahydrosiladifenidol | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| ifenprodil | Sus scrofa (pig) | Potency | 10.3992 | 1 | 0 |
| imipramine | Sus scrofa (pig) | Potency | 5.2119 | 1 | 0 |
| isoproterenol | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| 1-(2-naphthalenyl)-3-[(phenylmethyl)-propan-2-ylamino]-1-propanone | Sus scrofa (pig) | Potency | 13.0918 | 1 | 0 |
| loperamide | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one | Sus scrofa (pig) | Potency | 0.4140 | 1 | 0 |
| maprotiline | Sus scrofa (pig) | Potency | 0.5212 | 1 | 0 |
| ml 7 | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| naftopidil | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| nicardipine | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| niclosamide | Sus scrofa (pig) | Potency | 2.0749 | 1 | 0 |
| nitrendipine | Sus scrofa (pig) | Potency | 13.0918 | 1 | 0 |
| nortriptyline | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| 4-(2'-methoxyphenyl)-1-(2'-(n-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine | Sus scrofa (pig) | Potency | 2.9309 | 1 | 0 |
| pd 169316 | Sus scrofa (pig) | Potency | 0.0083 | 1 | 0 |
| perphenazine | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| prazosin | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| prochlorperazine | Sus scrofa (pig) | Potency | 13.0918 | 1 | 0 |
| promazine | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| promethazine | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| propafenone | Sus scrofa (pig) | Potency | 16.4816 | 1 | 0 |
| raloxifene | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| ritanserin | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| terfenadine | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| trifluperidol | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| triflupromazine | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| ics 205-930 | Sus scrofa (pig) | Potency | 1.6482 | 1 | 0 |
| tyrphostin a9 | Sus scrofa (pig) | Potency | 2.3281 | 1 | 0 |
| cytarabine | Sus scrofa (pig) | Potency | 0.9268 | 1 | 0 |
| rotenone | Sus scrofa (pig) | Potency | 0.0465 | 1 | 0 |
| azacitidine | Sus scrofa (pig) | Potency | 0.7362 | 1 | 0 |
| pimozide | Sus scrofa (pig) | Potency | 16.4816 | 1 | 0 |
| propionylpromazine | Sus scrofa (pig) | Potency | 16.4816 | 1 | 0 |
| camptothecin | Sus scrofa (pig) | Potency | 0.1040 | 1 | 0 |
| butaclamol | Sus scrofa (pig) | Potency | 13.0918 | 1 | 0 |
| methyldopa | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| idarubicin | Sus scrofa (pig) | Potency | 0.4140 | 1 | 0 |
| paroxetine | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| idazoxan | Sus scrofa (pig) | Potency | 6.5614 | 1 | 0 |
| mifepristone | Sus scrofa (pig) | Potency | 11.6681 | 1 | 0 |
| salmeterol xinafoate | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| mibefradil | Sus scrofa (pig) | Potency | 10.3992 | 1 | 0 |
| aptiganel | Sus scrofa (pig) | Potency | 16.4816 | 1 | 0 |
| mevastatin | Sus scrofa (pig) | Potency | 16.4816 | 1 | 0 |
| lercanidipine | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| sertraline | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| sk&f 95282 | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| zpck | Sus scrofa (pig) | Potency | 5.2119 | 1 | 0 |
| gr 127935 | Sus scrofa (pig) | Potency | 5.8479 | 1 | 0 |
| tetradecanoylphorbol acetate | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| indatraline | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| l 741626 | Sus scrofa (pig) | Potency | 2.3281 | 1 | 0 |
| fiduxosin | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| sk&f 75670 | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| nsc 95397 | Sus scrofa (pig) | Potency | 3.6898 | 1 | 0 |
| nu 6027 | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| 5-hydroxytryptophan | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| tosylphenylalanyl chloromethyl ketone | Sus scrofa (pig) | Potency | 20.7491 | 1 | 0 |
| resveratrol | Sus scrofa (pig) | Potency | 3.6898 | 1 | 0 |
| thapsigargin | Sus scrofa (pig) | Potency | 0.0037 | 1 | 0 |
| 6-bromoindirubin-3'-oxime | Sus scrofa (pig) | Potency | 2.3281 | 1 | 0 |
| 3,3',4,5'-tetrahydroxystilbene | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| 3,4-methylenedioxy-beta-nitrostyrene | Sus scrofa (pig) | Potency | 2.0749 | 1 | 0 |
| 10,11-dihydroxy-n-allylnoraporphine | Sus scrofa (pig) | Potency | 7.3621 | 1 | 0 |
| fluoxetine | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| amn082 | Sus scrofa (pig) | Potency | 13.0918 | 1 | 0 |
| tamoxifen | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| stattic | Sus scrofa (pig) | Potency | 1.8493 | 1 | 0 |
| cgp 74514a | Sus scrofa (pig) | Potency | 2.9309 | 1 | 0 |
| 1,4-bis[2-(4-hydroxyphenyl)ethylamino]anthracene-9,10-dione | Sus scrofa (pig) | Potency | 4.6451 | 1 | 0 |
| nemadipine-a | Sus scrofa (pig) | Potency | 20.7491 | 1 | 0 |
| bp 897 | Sus scrofa (pig) | Potency | 16.4816 | 1 | 0 |
| sb 242084 | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| bw 723c86 | Sus scrofa (pig) | Potency | 13.0918 | 1 | 0 |
| cyclosporine | Sus scrofa (pig) | Potency | 4.6451 | 1 | 0 |
| myricetin | Sus scrofa (pig) | Potency | 16.4816 | 1 | 0 |
| caffeic acid phenethyl ester | Sus scrofa (pig) | Potency | 0.6561 | 1 | 0 |
| n-oleoyldopamine | Sus scrofa (pig) | Potency | 5.2119 | 1 | 0 |
| fenretinide | Sus scrofa (pig) | Potency | 13.0918 | 1 | 0 |
| as 605240 | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| su 9516 | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| olvanil | Sus scrofa (pig) | Potency | 1.6482 | 1 | 0 |
| (3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| casein kinase ii | Sus scrofa (pig) | Potency | 1.8493 | 1 | 0 |
| tyrphostin ag 555 | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| n,n,n-trimethyl-1-(4-stilbenoxy)-2-propylammonium iodide | Sus scrofa (pig) | Potency | 0.1167 | 1 | 0 |
| 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2h-pyran-2-one | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| su 4312 | Sus scrofa (pig) | Potency | 0.0083 | 1 | 0 |
| a 77636 | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| (8R)-7-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| (8R)-7-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| dilazep(2+) | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| erythro-dihydrosphingosine | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| l 162313 | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| 3,4-dichloro-n-methyl-n-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide, (trans)-(-)-isomer | Sus scrofa (pig) | Potency | 14.6892 | 1 | 0 |
| methylhistaprodifen | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| (5R)-9-bromo-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol | Sus scrofa (pig) | Potency | 23.2809 | 1 | 0 |
| N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamide | Sus scrofa (pig) | Potency | 5.8479 | 1 | 0 |
| b 015 | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
| calcimycin | Sus scrofa (pig) | Potency | 1.4689 | 1 | 0 |
| bix 01294 | Sus scrofa (pig) | Potency | 2.6122 | 1 | 0 |
| norclozapine | Sus scrofa (pig) | Potency | 18.4927 | 1 | 0 |
| ag-879 | Sus scrofa (pig) | Potency | 26.1216 | 1 | 0 |
Drugs with Inhibition Measurements
trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist.Journal of medicinal chemistry, , Nov-16, Volume: 49, Issue:23, 2006
trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist.Journal of medicinal chemistry, , Nov-16, Volume: 49, Issue:23, 2006