Page last updated: 2024-08-07 20:54:54

Olfactory receptor 51E2

An olfactory receptor 51E2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H255]

Synonyms

HPRAJ;
Olfactory receptor OR11-16;
Prostate-specific G-protein coupled receptor

Research

Bioassay Publications (0)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0)18.7374
1990's0 (0)18.2507
2000's0 (0)29.6817
2010's0 (0)24.3611
2020's0 (0)2.80

Compounds (18)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
isotretinoinHomo sapiens (human)IC500.160010

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
alpha-ketoglutaric acidHomo sapiens (human)EC500.005510
glycineHomo sapiens (human)EC500.058010
hydroxypyruvic acidHomo sapiens (human)EC500.420010
palmitic acidHomo sapiens (human)EC500.009810
ureaHomo sapiens (human)EC500.023010
estriolHomo sapiens (human)EC5053.000010
epitestosteroneHomo sapiens (human)EC500.000710
glycylglycineHomo sapiens (human)EC5011.000010
2-pyrrolidoneHomo sapiens (human)EC500.001910
n-acetylglutamic acidHomo sapiens (human)EC500.000210
tetrahydrocurcuminHomo sapiens (human)EC500.570010
histidinolHomo sapiens (human)EC500.000010
n-acetyl-n-formyl-5-methoxykynurenamineHomo sapiens (human)EC5012.000010
androstane-3,17-dione, (5alpha)-isomerHomo sapiens (human)EC500.000810
19-hydroxy-4-androstene-3,17-dioneHomo sapiens (human)EC500.000110
bradykininHomo sapiens (human)EC500.001310
8-hydroxyguanineHomo sapiens (human)EC500.000010

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
nuclear steroid receptor activitymolecular functionCombining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. [GOC:signaling, PMID:14708019]
G protein-coupled receptor activitymolecular functionCombining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
olfactory receptor activitymolecular functionCombining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]
signaling receptor activitymolecular functionReceiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling]

Located In

This protein is located in 3 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
early endosome membranecellular componentThe lipid bilayer surrounding an early endosome. [GOC:pz]
intracellular organellecellular componentOrganized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. [GOC:go_curators]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 9 target(s):

TargetCategoryDefinition
adenylate cyclase-activating G protein-coupled receptor signaling pathwaybiological processA G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
cell migrationbiological processThe controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
melanocyte differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of a melanocyte. [GOC:mah]
steroid hormone mediated signaling pathwaybiological processThe series of molecular signals mediated by a steroid hormone binding to a receptor. [PMID:12606724]
positive regulation of blood pressurebiological processAny process in which the force of blood traveling through the circulatory system is increased. [GOC:go_curators, GOC:mtg_cardio]
detection of chemical stimulus involved in sensory perception of smellbiological processThe series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal. [GOC:ai]
cellular response to fatty acidbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. [GOC:mah]
melanocyte proliferationbiological processThe multiplication or reproduction of melanocytes, resulting in the expansion of a cell population. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance. [CL:0000148, GOC:uh, PMID:22637532]
positive regulation of renin secretion into blood streambiological processAny process that activates or increases the frequency, rate or extent of renin secretion into blood stream. [GOC:TermGenie]