A cytosolic endo-beta-N-acetylglucosaminidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFI3]
ENGase;
EC 3.2.1.96
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| lansoprazole | Homo sapiens (human) | IC50 | 24.3800 | 1 | 1 |
| omeprazole | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| rabeprazole | Homo sapiens (human) | IC50 | 4.4700 | 1 | 1 |
| tenatoprazole | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| dexlansoprazole | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity | molecular function | Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. [EC:3.2.1.96] |
| hydrolase activity, hydrolyzing O-glycosyl compounds | molecular function | Catalysis of the hydrolysis of any O-glycosyl bond. [GOC:mah] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| protein folding | biological process | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. [GOC:go_curators, GOC:rb] |
| protein deglycosylation | biological process | The removal of sugar residues from a glycosylated protein. [GOC:mah] |