Cytochrome P450 2A13

A cytochrome P450 2A that is a translation product of the CYP2A13 gene in human. [PRO:DNx, UniProtKB:Q16696]

EC 1.14.14.1;
CYPIIA13

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tryptamine	Homo sapiens (human)	Ki	16.0000	1	1
methoxsalen	Homo sapiens (human)	Ki	0.0400	1	1
pilocarpine	Homo sapiens (human)	Ki	1.4000	1	1
4-(dimethylamino)benzaldehyde	Homo sapiens (human)	Ki	17.0000	1	1
beta-nicotyrine	Homo sapiens (human)	Ki	5.6000	1	1
phenethyl isothiocyanate	Homo sapiens (human)	Ki	3.8000	1	1
tranylcypromine	Homo sapiens (human)	IC50	6.2000	1	1
1-n-butylimidazole	Homo sapiens (human)	IC50	65.0000	1	2
proadifen hydrochloride	Homo sapiens (human)	IC50	19.0000	1	1
pirlindole	Homo sapiens (human)	IC50	36.0000	1	1
nicotine	Homo sapiens (human)	Ki	72.0000	1	1
kaf156	Homo sapiens (human)	IC50	6.0000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tryptamine	Homo sapiens (human)	Kd	5.2000	1	1
methoxsalen	Homo sapiens (human)	Kd	1.6000	1	1
pilocarpine	Homo sapiens (human)	Kd	3.0000	1	1
4-(dimethylamino)benzaldehyde	Homo sapiens (human)	Kd	0.6500	1	1
beta-nicotyrine	Homo sapiens (human)	Kd	8.2000	1	1
phenethyl isothiocyanate	Homo sapiens (human)	Kd	0.4300	1	1
nicotine	Homo sapiens (human)	Kd	54.0000	1	1

This protein enables 7 target(s):

Target	Category	Definition
monooxygenase activity	molecular function	Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. [ISBN:0198506732]
iron ion binding	molecular function	Binding to an iron (Fe) ion. [GOC:ai]
coumarin 7-hydroxylase activity	molecular function	Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. [Reactome:163103]
heme binding	molecular function	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai]
aromatase activity	molecular function	Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. [GOC:cb]
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	molecular function	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]
arachidonic acid epoxygenase activity	molecular function	Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid. [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399, PMID:18952572]

This protein is located in 1 target(s):

Target	Category	Definition
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

This protein is active in 2 target(s):

Target	Category	Definition
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is involved in 4 target(s):

Target	Category	Definition
coumarin metabolic process	biological process	The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids. [GOC:lr, GOC:yl]
aflatoxin metabolic process	biological process	The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. [GOC:ai]
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
epoxygenase P450 pathway	biological process	The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. [GOC:mah, PMID:17979511]