Page last updated: 2024-08-07 23:44:36
Serine/threonine-protein kinase PknB
A protein that is a translation product of the pknB gene in Mycobacterium tuberculosis H37Rv. [PRO:DNx, UniProtKB:P9WI81]
Synonyms
EC 2.7.11.1
Research
Bioassay Publications (1)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (69)
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| imatinib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| staurosporine | Mycobacterium tuberculosis H37Rv | Kd | 0.0880 | 1 | 1 |
| gefitinib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| lestaurtinib | Mycobacterium tuberculosis H37Rv | Kd | 0.0550 | 1 | 1 |
| vatalanib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| ruboxistaurin | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| canertinib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| birb 796 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| sb 203580 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| enzastaurin | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| erlotinib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| lapatinib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| sorafenib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| pd 173955 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| s 1033 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| bms 387032 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| tandutinib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| vx-745 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| dasatinib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| zd 6474 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| alvocidib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| bosutinib | Mycobacterium tuberculosis H37Rv | Kd | 5.5000 | 1 | 1 |
| su 11248 | Mycobacterium tuberculosis H37Rv | Kd | 0.0870 | 1 | 1 |
| vx680 | Mycobacterium tuberculosis H37Rv | Kd | 2.2000 | 1 | 1 |
| axitinib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| pd 184352 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| bms345541 | Mycobacterium tuberculosis H37Rv | Kd | 2.4000 | 1 | 1 |
| midostaurin | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| ki 20227 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| pi103 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| hki 272 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| tofacitinib | Mycobacterium tuberculosis H37Rv | Kd | 2.0000 | 1 | 1 |
| n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| cediranib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| masitinib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| pazopanib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| azd 6244 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| su 14813 | Mycobacterium tuberculosis H37Rv | Kd | 0.3200 | 1 | 1 |
| bibw 2992 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| tg100-115 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| pha 665752 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one | Mycobacterium tuberculosis H37Rv | Kd | 0.0340 | 1 | 1 |
| brivanib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| at 7519 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| bi 2536 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| nvp-ast487 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| kw 2449 | Mycobacterium tuberculosis H37Rv | Kd | 0.2400 | 1 | 1 |
| abt 869 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| gw 2580 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| crizotinib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| chir-265 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| motesanib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| mln8054 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| GDC-0879 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| gsk 461364 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| azd 1152-hqpa | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| nvp-tae684 | Mycobacterium tuberculosis H37Rv | Kd | 1.2000 | 1 | 1 |
| fedratinib | Mycobacterium tuberculosis H37Rv | Kd | 0.1000 | 1 | 1 |
| gsk690693 | Mycobacterium tuberculosis H37Rv | Kd | 0.0032 | 1 | 1 |
| gdc 0941 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| plx 4720 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| sgx 523 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| quizartinib | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| incb-018424 | Mycobacterium tuberculosis H37Rv | Kd | 4.2000 | 1 | 1 |
| gsk 1838705a | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| gsk 1363089 | Mycobacterium tuberculosis H37Rv | Kd | 10.0000 | 1 | 1 |
| chir 258 | Mycobacterium tuberculosis H37Rv | Kd | 0.3000 | 1 | 1 |
| nintedanib | Mycobacterium tuberculosis H37Rv | Kd | 0.0036 | 1 | 1 |
| pp242 | Mycobacterium tuberculosis H37Rv | Kd | 2.9000 | 1 | 1 |