Page last updated: 2024-11-02

pd 153035 and Necrosis

pd 153035 has been researched along with Necrosis in 3 studies

4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline: structure given in first source
PD-153035 : A member of the class of quinazolines carrying a 3-bromophenylamino substituent at position 4 and two methoxy substituents at positions 6 and 7.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"Glioblastoma (GB) is the most frequent primary brain tumor in adults with a dismal prognosis despite aggressive treatment including surgical resection, radiotherapy and chemotherapy with the alkylating agent temozolomide."2.87Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma. ( Harter, PN; Mittelbronn, M; Pietsch, T; Reuter, D; Ronellenfitsch, MW; Senft, C; Steinbach, JP; Urban, H; Westphal, M; Zeiner, PS, 2018)
"Hypertension is frequently associated with the development of renal vascular and glomerular fibrosis."1.32Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition. ( Chansel, D; Chatziantoniou, C; Dussaule, JC; Flamant, M; François, H; Placier, S; Tharaux, PL, 2004)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ronellenfitsch, MW1
Zeiner, PS1
Mittelbronn, M1
Urban, H1
Pietsch, T1
Reuter, D1
Senft, C1
Steinbach, JP1
Westphal, M1
Harter, PN1
Mimeault, M1
Pommery, N1
Hénichart, JP1
François, H1
Placier, S1
Flamant, M1
Tharaux, PL1
Chansel, D1
Dussaule, JC1
Chatziantoniou, C1

Trials

1 trial available for pd 153035 and Necrosis

ArticleYear
Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma.
    Acta neuropathologica communications, 2018, 08-21, Volume: 6, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Antibodies, Monoclonal, Humanized; Basic Helix-Loop-Helix Tran

2018

Other Studies

2 other studies available for pd 153035 and Necrosis

ArticleYear
Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines.
    International journal of cancer, 2003, Aug-10, Volume: 106, Issue:1

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Cell Division; Cell Separation; Ceramides; Cyclic AMP; C

2003
Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:7

    Topics: Animals; Capillaries; Collagen; Collagen Type I; Creatinine; Endothelin-1; ErbB Receptors; Fibrosis;

2004