pd 153035 has been researched along with Necrosis in 3 studies
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline: structure given in first source
PD-153035 : A member of the class of quinazolines carrying a 3-bromophenylamino substituent at position 4 and two methoxy substituents at positions 6 and 7.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glioblastoma (GB) is the most frequent primary brain tumor in adults with a dismal prognosis despite aggressive treatment including surgical resection, radiotherapy and chemotherapy with the alkylating agent temozolomide." | 2.87 | Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma. ( Harter, PN; Mittelbronn, M; Pietsch, T; Reuter, D; Ronellenfitsch, MW; Senft, C; Steinbach, JP; Urban, H; Westphal, M; Zeiner, PS, 2018) |
| "Hypertension is frequently associated with the development of renal vascular and glomerular fibrosis." | 1.32 | Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition. ( Chansel, D; Chatziantoniou, C; Dussaule, JC; Flamant, M; François, H; Placier, S; Tharaux, PL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ronellenfitsch, MW | 1 |
| Zeiner, PS | 1 |
| Mittelbronn, M | 1 |
| Urban, H | 1 |
| Pietsch, T | 1 |
| Reuter, D | 1 |
| Senft, C | 1 |
| Steinbach, JP | 1 |
| Westphal, M | 1 |
| Harter, PN | 1 |
| Mimeault, M | 1 |
| Pommery, N | 1 |
| Hénichart, JP | 1 |
| François, H | 1 |
| Placier, S | 1 |
| Flamant, M | 1 |
| Tharaux, PL | 1 |
| Chansel, D | 1 |
| Dussaule, JC | 1 |
| Chatziantoniou, C | 1 |
1 trial available for pd 153035 and Necrosis
| Article | Year |
|---|---|
Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma.
Topics: Adaptor Proteins, Signal Transducing; Antibodies, Monoclonal, Humanized; Basic Helix-Loop-Helix Tran | 2018 |
2 other studies available for pd 153035 and Necrosis
| Article | Year |
|---|---|
Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Cell Division; Cell Separation; Ceramides; Cyclic AMP; C | 2003 |
Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition.
Topics: Animals; Capillaries; Collagen; Collagen Type I; Creatinine; Endothelin-1; ErbB Receptors; Fibrosis; | 2004 |