Page last updated: 2024-10-27

furosemide and Necrosis

furosemide has been researched along with Necrosis in 28 studies

Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"We report a case of myocardial necrosis in a newborn after treatment of the mother with long-term subcutaneous terbutaline."7.68Myocardial necrosis in a newborn after long-term maternal subcutaneous terbutaline infusion for suppression of preterm labor. ( Case, CL; Fletcher, SE; Fyfe, DA; Newman, RB; Upshur, JK; Wiles, HB, 1991)
" FA produced necrosis of the epithelial cells of the convoluted tubules as the detection of the beta-aminoisobutyric acid end product of DNA and thymine catabolism indicated."3.70DNA degradation in the kidney of folic acid-treated guinea pigs. ( Gourgiotis, D; Kavazarakis, E; Messaritaki, A; Moustaki, M; Nakopoulou, L; Nicolaidou, P; Tzaki, M; Zeis, MP; Zeis, PM, 2000)
"We report a case of myocardial necrosis in a newborn after treatment of the mother with long-term subcutaneous terbutaline."3.68Myocardial necrosis in a newborn after long-term maternal subcutaneous terbutaline infusion for suppression of preterm labor. ( Case, CL; Fletcher, SE; Fyfe, DA; Newman, RB; Upshur, JK; Wiles, HB, 1991)
"Previous studies have shown that oral administration of minoxidil on 2 consecutive days produces an increase in heart rate and myocardial necrosis in Beagle dogs."3.66Divergent effects of propranolol and furosemide pretreatment on acute cardiomyopathy induced by minoxidil in beagle dogs. ( Balazs, T; Ferrans, VJ; Herman, EH; Young, RS, 1981)
"Furosemide-induced (400mg/kg ip) hepatotoxicity progressing to centrilobular necrosis was studied by light and electron microscopy in Swiss white mice."3.66Furosemide induced hepatotoxicity. ( McElligott, TF; Walker, RM, 1981)
"The possibility that furosemide-induced hepatic necrosis results from the formation of a chemically reactive hepatotoxic metabolite has been examined."3.65Metabolic activation of furosemide to a chemically reactive, hepatotoxic metabolite. ( Jollow, DJ; Mitchell, JR; Nelson, WL; Potter, WZ; Sasame, HA, 1976)
" A drug that could be a safe and effective treatment in humans could cause toxicity in animals, preventing it from being used in humans."1.42Humanized thymidine kinase-NOG mice can be used to identify drugs that cause animal-specific hepatotoxicity: a case study with furosemide. ( Michie, SA; Peltz, G; Takeda, S; Wu, M; Xu, D; Zheng, M, 2015)
"Nephrotoxicity of cefodizime sodium (THR-221), a new cephem antibiotic, was studied in rats by comparing its toxic effect with those of other cephem antibiotics including cephaloridine (CER), cefazolin (CEZ) and cefmetazol (CMZ)."1.27[Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration]. ( Hayashi, T; Irimura, K; Kuwata, M; Maruden, A; Morita, K, 1988)
" We believe that repeated renograms, a reduction in azathioprine dosage and careful dialysis is the only treatment necessary."1.26Etiology and prognosis in acute post-transplant renal failure. ( Buselmeier, TJ; Casali, RE; Kjellstrand, CM; Najarian, JS; Shideman, JR; Simmons, RL, 1976)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199020 (71.43)18.7374
1990's3 (10.71)18.2507
2000's4 (14.29)29.6817
2010's1 (3.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Xu, D1
Michie, SA1
Zheng, M1
Takeda, S1
Wu, M1
Peltz, G1
Russell, NJ1
Irwin, PJ1
Hopper, BJ1
Olivry, T1
Nicholls, PK1
Jacotot, T1
Leroux, B1
Daoud, S1
Mesmin, F1
Coffin, R1
Arai, A1
Yan, W1
Wakabayashi, S1
Hayashi, S1
Inazawa, J1
Miura, O1
Luderschmidt, C1
Gutschow, K1
Baumeister, RG1
Albrich, W1
Eiermann, W1
Herman, EH1
Balazs, T1
Ferrans, VJ1
Young, RS1
Walker, RM1
McElligott, TF1
Dib, JA1
Cooper-Vastola, SA1
Meirelles, RF1
Bagchi, S1
Caboclo, JL1
Holm, C1
Eisenberg, MM1
Ohno, K1
Takada, T1
Terada, M1
Satoh, M1
Suzuki, E1
Wada, K1
Hirono, T1
Arakawa, M1
Zeis, PM1
Tzaki, M1
Nakopoulou, L1
Nicolaidou, P1
Kavazarakis, E1
Messaritaki, A1
Moustaki, M1
Zeis, MP1
Gourgiotis, D1
Cowley, AW1
Roman, RJ1
Kaldunski, ML1
Dumas, P1
Dickhout, JG1
Greene, AS1
Jacob, HJ1
Corcelle, P1
Poirson, B1
Dournovo, P1
Duron, JJ1
Garaix, JP1
Mitchell, JR5
Potter, WZ3
McMurtry, RJ2
Nelson, SD1
Thorgeirsson, SS2
Dybing, E2
Kjellstrand, CM1
Casali, RE1
Simmons, RL1
Shideman, JR1
Buselmeier, TJ1
Najarian, JS1
Spitznagle, LA1
Wirth, PJ1
Boobis, SW1
Nelson, WL2
Sasame, HA1
Jollow, DJ2
Fletcher, SE1
Fyfe, DA1
Case, CL1
Wiles, HB1
Upshur, JK1
Newman, RB1
Majewska, T1
Matysek, M1
Milik, A1
Dawidson, I1
Peters, P1
Sagalowsky, A1
Abshier, D1
Coorpender, L1
Hayashi, T1
Maruden, A1
Irimura, K1
Kuwata, M1
Morita, K1
Clasen, RA1
Pandolfi, S1
Casey, D1
Hinson, JA1
Gillette, JR1
Lawson, DH1
Macadam, RF1
Singh, MH1
Gavras, H1
Hartz, S1
Turnbull, D1
Linton, AL1
Andersen, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00005268]0 participants Observational1995-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for furosemide and Necrosis

ArticleYear
Successful imatinib treatment of cardiac involvement of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia followed by severe hepatotoxicity.
    International journal of hematology, 2007, Volume: 86, Issue:3

    Topics: Adult; Antineoplastic Agents; Benzamides; Biopsy; Chemical and Drug Induced Liver Injury; Chromosome

2007
Drug metabolism in the production of liver injury.
    The Medical clinics of North America, 1975, Volume: 59, Issue:4

    Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur

1975
Metabolic activation: biochemical basis for many drug-induced liver injuries.
    Progress in liver diseases, 1976, Volume: 5

    Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hyp

1976

Other Studies

25 other studies available for furosemide and Necrosis

ArticleYear
Humanized thymidine kinase-NOG mice can be used to identify drugs that cause animal-specific hepatotoxicity: a case study with furosemide.
    The Journal of pharmacology and experimental therapeutics, 2015, Volume: 354, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Furosemide; Hepatocytes; Hu

2015
Acute necrotising pulmonary vasculitis and pulmonary hypertension in a juvenile dog.
    The Journal of small animal practice, 2008, Volume: 49, Issue:7

    Topics: Acute Disease; Animals; Anti-Anxiety Agents; Dog Diseases; Dogs; Fatal Outcome; Female; Furosemide;

2008
[Prenatal obstruction of the left hypogastric artery].
    Annales de pediatrie, 1976, Feb-02, Volume: 23, Issue:2

    Topics: Angiography; Arterial Occlusive Diseases; Buttocks; Causality; Diuretics; Edema; Female; Furosemide;

1976
[Cutaneous coumarin necrosis of the breast].
    Deutsche medizinische Wochenschrift (1946), 1983, Sep-16, Volume: 108, Issue:37

    Topics: 4-Hydroxycoumarins; Breast Diseases; Bromhexine; Cimetidine; Female; Furosemide; Humans; Middle Aged

1983
Divergent effects of propranolol and furosemide pretreatment on acute cardiomyopathy induced by minoxidil in beagle dogs.
    Toxicology, 1981, Volume: 20, Issue:2-3

    Topics: Animals; Dogs; Drug Interactions; Furosemide; Heart Diseases; Heart Rate; Hydrochlorothiazide; Male;

1981
Furosemide induced hepatotoxicity.
    The Journal of pathology, 1981, Volume: 135, Issue:4

    Topics: Animals; Chemical and Drug Induced Liver Injury; Erythrocytes; Furosemide; Liver; Liver Diseases; Ma

1981
Acute effects of ethanol and ethanol plus furosemide on pancreatic capillary blood flow in rats.
    American journal of surgery, 1993, Volume: 166, Issue:1

    Topics: Amylases; Animals; Blood Pressure; Capillaries; Chlorides; Drug Combinations; Ethanol; Furosemide; H

1993
[Recovery from descending necrotizing mediastinitis and multiple organic failure after seven months of mechanical ventilation].
    Nihon Kyobu Shikkan Gakkai zasshi, 1996, Volume: 34, Issue:9

    Topics: Catecholamines; Female; Furosemide; Humans; Male; Mediastinitis; Middle Aged; Multiple Organ Failure

1996
DNA degradation in the kidney of folic acid-treated guinea pigs.
    Cytobios, 2000, Volume: 102, Issue:400

    Topics: Acute Kidney Injury; Aminoisobutyric Acids; Animals; Chromatography, Thin Layer; Creatinine; Diureti

2000
Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:2 Pt 2

    Topics: Angiotensin II; Animals; Blood Pressure; Fibrosis; Furosemide; Gene Transfer Techniques; Genetic The

2001
[Fatal necrotizing pancreatitis following drowning in a swimming pool].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1976, Nov-09, Volume: 52, Issue:38

    Topics: Acute Disease; Acute Kidney Injury; Adult; Drowning; Epilepsy; Furosemide; Hemolysis; Humans; Hydroc

1976
Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine.
    Toxicology and applied pharmacology, 1977, Volume: 42, Issue:2

    Topics: Animals; Cephaloridine; Chemical and Drug Induced Liver Injury; Furans; Furosemide; In Vitro Techniq

1977
Etiology and prognosis in acute post-transplant renal failure.
    The American journal of medicine, 1976, Volume: 61, Issue:2

    Topics: Acute Kidney Injury; Adolescent; Adult; Diagnostic Errors; Furosemide; Graft Rejection; Humans; Kidn

1976
The role of biliary excretion in the hepatotoxicity of furosemide in the mouse.
    Toxicology and applied pharmacology, 1977, Volume: 39, Issue:2

    Topics: Animals; Autoradiography; Bile; Blood Proteins; Chemical and Drug Induced Liver Injury; Furosemide;

1977
Metabolic activation of furosemide to a chemically reactive, hepatotoxic metabolite.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 199, Issue:1

    Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry

1976
[Drug induced liver injury. Chemical liver necrosis caused by formation of reactive metabolites].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Feb-10, Volume: 96, Issue:4

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug

1976
Myocardial necrosis in a newborn after long-term maternal subcutaneous terbutaline infusion for suppression of preterm labor.
    American journal of obstetrics and gynecology, 1991, Volume: 165, Issue:5 Pt 1

    Topics: Captopril; Cardiomyopathies; Digoxin; Echocardiography; Electrocardiography; Female; Furosemide; Hum

1991
[Histological and histochemical studies on the effect of furosemide on rat liver].
    Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina, 1988, Volume: 43

    Topics: Acid Phosphatase; Adenosine Triphosphatases; Animals; Furosemide; Glycogen; Liver; Male; Necrosis; R

1988
The effect of intraoperative fluid management on the incidence of acute tubular necrosis.
    Transplantation proceedings, 1987, Volume: 19, Issue:1 Pt 3

    Topics: Furosemide; Graft Survival; Humans; Kidney Transplantation; Kidney Tubules; Mannitol; Necrosis; Repe

1987
[Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration].
    The Journal of toxicological sciences, 1988, Volume: 13 Suppl 1

    Topics: Animals; Cefazolin; Cefmetazole; Cefotaxime; Cephaloridine; Drug Administration Schedule; Drug Thera

1988
Furosemide and pentobarbital in cryogenic cerebral injury and edema.
    Neurology, 1974, Volume: 24, Issue:7

    Topics: Animals; Brain; Brain Edema; Cerebral Hemorrhage; Drug Synergism; Erythrocytes; Freezing; Furosemide

1974
Hepatic necrosis caused by furosemide.
    Nature, 1974, Oct-11, Volume: 251, Issue:5475

    Topics: Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Furosemide; Injec

1974
Commentary. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity.
    Biochemical pharmacology, 1974, Oct-15, Volume: 23, Issue:20

    Topics: Acetaminophen; Animals; Autoradiography; Benzene Derivatives; Carbon Tetrachloride Poisoning; Carcin

1974
Effect of furosemide on antibiotic-induced renal damage in rats.
    The Journal of infectious diseases, 1972, Volume: 126, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Cephaloridine; Cephalothin; Colistin; Female; Furosemide; Glycerol;

1972
[Necroses of the small intestine after administration of potassium].
    Ugeskrift for laeger, 1966, Mar-31, Volume: 128, Issue:13

    Topics: Adult; Furosemide; Humans; Intestine, Small; Male; Necrosis; Potassium Chloride

1966