furosemide has been researched along with Necrosis in 28 studies
Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a case of myocardial necrosis in a newborn after treatment of the mother with long-term subcutaneous terbutaline." | 7.68 | Myocardial necrosis in a newborn after long-term maternal subcutaneous terbutaline infusion for suppression of preterm labor. ( Case, CL; Fletcher, SE; Fyfe, DA; Newman, RB; Upshur, JK; Wiles, HB, 1991) |
| " FA produced necrosis of the epithelial cells of the convoluted tubules as the detection of the beta-aminoisobutyric acid end product of DNA and thymine catabolism indicated." | 3.70 | DNA degradation in the kidney of folic acid-treated guinea pigs. ( Gourgiotis, D; Kavazarakis, E; Messaritaki, A; Moustaki, M; Nakopoulou, L; Nicolaidou, P; Tzaki, M; Zeis, MP; Zeis, PM, 2000) |
| "We report a case of myocardial necrosis in a newborn after treatment of the mother with long-term subcutaneous terbutaline." | 3.68 | Myocardial necrosis in a newborn after long-term maternal subcutaneous terbutaline infusion for suppression of preterm labor. ( Case, CL; Fletcher, SE; Fyfe, DA; Newman, RB; Upshur, JK; Wiles, HB, 1991) |
| "Previous studies have shown that oral administration of minoxidil on 2 consecutive days produces an increase in heart rate and myocardial necrosis in Beagle dogs." | 3.66 | Divergent effects of propranolol and furosemide pretreatment on acute cardiomyopathy induced by minoxidil in beagle dogs. ( Balazs, T; Ferrans, VJ; Herman, EH; Young, RS, 1981) |
| "Furosemide-induced (400mg/kg ip) hepatotoxicity progressing to centrilobular necrosis was studied by light and electron microscopy in Swiss white mice." | 3.66 | Furosemide induced hepatotoxicity. ( McElligott, TF; Walker, RM, 1981) |
| "The possibility that furosemide-induced hepatic necrosis results from the formation of a chemically reactive hepatotoxic metabolite has been examined." | 3.65 | Metabolic activation of furosemide to a chemically reactive, hepatotoxic metabolite. ( Jollow, DJ; Mitchell, JR; Nelson, WL; Potter, WZ; Sasame, HA, 1976) |
| " A drug that could be a safe and effective treatment in humans could cause toxicity in animals, preventing it from being used in humans." | 1.42 | Humanized thymidine kinase-NOG mice can be used to identify drugs that cause animal-specific hepatotoxicity: a case study with furosemide. ( Michie, SA; Peltz, G; Takeda, S; Wu, M; Xu, D; Zheng, M, 2015) |
| "Nephrotoxicity of cefodizime sodium (THR-221), a new cephem antibiotic, was studied in rats by comparing its toxic effect with those of other cephem antibiotics including cephaloridine (CER), cefazolin (CEZ) and cefmetazol (CMZ)." | 1.27 | [Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration]. ( Hayashi, T; Irimura, K; Kuwata, M; Maruden, A; Morita, K, 1988) |
| " We believe that repeated renograms, a reduction in azathioprine dosage and careful dialysis is the only treatment necessary." | 1.26 | Etiology and prognosis in acute post-transplant renal failure. ( Buselmeier, TJ; Casali, RE; Kjellstrand, CM; Najarian, JS; Shideman, JR; Simmons, RL, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (71.43) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 4 (14.29) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, D | 1 |
| Michie, SA | 1 |
| Zheng, M | 1 |
| Takeda, S | 1 |
| Wu, M | 1 |
| Peltz, G | 1 |
| Russell, NJ | 1 |
| Irwin, PJ | 1 |
| Hopper, BJ | 1 |
| Olivry, T | 1 |
| Nicholls, PK | 1 |
| Jacotot, T | 1 |
| Leroux, B | 1 |
| Daoud, S | 1 |
| Mesmin, F | 1 |
| Coffin, R | 1 |
| Arai, A | 1 |
| Yan, W | 1 |
| Wakabayashi, S | 1 |
| Hayashi, S | 1 |
| Inazawa, J | 1 |
| Miura, O | 1 |
| Luderschmidt, C | 1 |
| Gutschow, K | 1 |
| Baumeister, RG | 1 |
| Albrich, W | 1 |
| Eiermann, W | 1 |
| Herman, EH | 1 |
| Balazs, T | 1 |
| Ferrans, VJ | 1 |
| Young, RS | 1 |
| Walker, RM | 1 |
| McElligott, TF | 1 |
| Dib, JA | 1 |
| Cooper-Vastola, SA | 1 |
| Meirelles, RF | 1 |
| Bagchi, S | 1 |
| Caboclo, JL | 1 |
| Holm, C | 1 |
| Eisenberg, MM | 1 |
| Ohno, K | 1 |
| Takada, T | 1 |
| Terada, M | 1 |
| Satoh, M | 1 |
| Suzuki, E | 1 |
| Wada, K | 1 |
| Hirono, T | 1 |
| Arakawa, M | 1 |
| Zeis, PM | 1 |
| Tzaki, M | 1 |
| Nakopoulou, L | 1 |
| Nicolaidou, P | 1 |
| Kavazarakis, E | 1 |
| Messaritaki, A | 1 |
| Moustaki, M | 1 |
| Zeis, MP | 1 |
| Gourgiotis, D | 1 |
| Cowley, AW | 1 |
| Roman, RJ | 1 |
| Kaldunski, ML | 1 |
| Dumas, P | 1 |
| Dickhout, JG | 1 |
| Greene, AS | 1 |
| Jacob, HJ | 1 |
| Corcelle, P | 1 |
| Poirson, B | 1 |
| Dournovo, P | 1 |
| Duron, JJ | 1 |
| Garaix, JP | 1 |
| Mitchell, JR | 5 |
| Potter, WZ | 3 |
| McMurtry, RJ | 2 |
| Nelson, SD | 1 |
| Thorgeirsson, SS | 2 |
| Dybing, E | 2 |
| Kjellstrand, CM | 1 |
| Casali, RE | 1 |
| Simmons, RL | 1 |
| Shideman, JR | 1 |
| Buselmeier, TJ | 1 |
| Najarian, JS | 1 |
| Spitznagle, LA | 1 |
| Wirth, PJ | 1 |
| Boobis, SW | 1 |
| Nelson, WL | 2 |
| Sasame, HA | 1 |
| Jollow, DJ | 2 |
| Fletcher, SE | 1 |
| Fyfe, DA | 1 |
| Case, CL | 1 |
| Wiles, HB | 1 |
| Upshur, JK | 1 |
| Newman, RB | 1 |
| Majewska, T | 1 |
| Matysek, M | 1 |
| Milik, A | 1 |
| Dawidson, I | 1 |
| Peters, P | 1 |
| Sagalowsky, A | 1 |
| Abshier, D | 1 |
| Coorpender, L | 1 |
| Hayashi, T | 1 |
| Maruden, A | 1 |
| Irimura, K | 1 |
| Kuwata, M | 1 |
| Morita, K | 1 |
| Clasen, RA | 1 |
| Pandolfi, S | 1 |
| Casey, D | 1 |
| Hinson, JA | 1 |
| Gillette, JR | 1 |
| Lawson, DH | 1 |
| Macadam, RF | 1 |
| Singh, MH | 1 |
| Gavras, H | 1 |
| Hartz, S | 1 |
| Turnbull, D | 1 |
| Linton, AL | 1 |
| Andersen, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00005268] | 0 participants | Observational | 1995-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for furosemide and Necrosis
| Article | Year |
|---|---|
Successful imatinib treatment of cardiac involvement of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia followed by severe hepatotoxicity.
Topics: Adult; Antineoplastic Agents; Benzamides; Biopsy; Chemical and Drug Induced Liver Injury; Chromosome | 2007 |
Drug metabolism in the production of liver injury.
Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur | 1975 |
Metabolic activation: biochemical basis for many drug-induced liver injuries.
Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hyp | 1976 |
25 other studies available for furosemide and Necrosis
| Article | Year |
|---|---|
Humanized thymidine kinase-NOG mice can be used to identify drugs that cause animal-specific hepatotoxicity: a case study with furosemide.
Topics: Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Furosemide; Hepatocytes; Hu | 2015 |
Acute necrotising pulmonary vasculitis and pulmonary hypertension in a juvenile dog.
Topics: Acute Disease; Animals; Anti-Anxiety Agents; Dog Diseases; Dogs; Fatal Outcome; Female; Furosemide; | 2008 |
[Prenatal obstruction of the left hypogastric artery].
Topics: Angiography; Arterial Occlusive Diseases; Buttocks; Causality; Diuretics; Edema; Female; Furosemide; | 1976 |
[Cutaneous coumarin necrosis of the breast].
Topics: 4-Hydroxycoumarins; Breast Diseases; Bromhexine; Cimetidine; Female; Furosemide; Humans; Middle Aged | 1983 |
Divergent effects of propranolol and furosemide pretreatment on acute cardiomyopathy induced by minoxidil in beagle dogs.
Topics: Animals; Dogs; Drug Interactions; Furosemide; Heart Diseases; Heart Rate; Hydrochlorothiazide; Male; | 1981 |
Furosemide induced hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Erythrocytes; Furosemide; Liver; Liver Diseases; Ma | 1981 |
Acute effects of ethanol and ethanol plus furosemide on pancreatic capillary blood flow in rats.
Topics: Amylases; Animals; Blood Pressure; Capillaries; Chlorides; Drug Combinations; Ethanol; Furosemide; H | 1993 |
[Recovery from descending necrotizing mediastinitis and multiple organic failure after seven months of mechanical ventilation].
Topics: Catecholamines; Female; Furosemide; Humans; Male; Mediastinitis; Middle Aged; Multiple Organ Failure | 1996 |
DNA degradation in the kidney of folic acid-treated guinea pigs.
Topics: Acute Kidney Injury; Aminoisobutyric Acids; Animals; Chromatography, Thin Layer; Creatinine; Diureti | 2000 |
Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat.
Topics: Angiotensin II; Animals; Blood Pressure; Fibrosis; Furosemide; Gene Transfer Techniques; Genetic The | 2001 |
[Fatal necrotizing pancreatitis following drowning in a swimming pool].
Topics: Acute Disease; Acute Kidney Injury; Adult; Drowning; Epilepsy; Furosemide; Hemolysis; Humans; Hydroc | 1976 |
Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine.
Topics: Animals; Cephaloridine; Chemical and Drug Induced Liver Injury; Furans; Furosemide; In Vitro Techniq | 1977 |
Etiology and prognosis in acute post-transplant renal failure.
Topics: Acute Kidney Injury; Adolescent; Adult; Diagnostic Errors; Furosemide; Graft Rejection; Humans; Kidn | 1976 |
The role of biliary excretion in the hepatotoxicity of furosemide in the mouse.
Topics: Animals; Autoradiography; Bile; Blood Proteins; Chemical and Drug Induced Liver Injury; Furosemide; | 1977 |
Metabolic activation of furosemide to a chemically reactive, hepatotoxic metabolite.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry | 1976 |
[Drug induced liver injury. Chemical liver necrosis caused by formation of reactive metabolites].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug | 1976 |
Myocardial necrosis in a newborn after long-term maternal subcutaneous terbutaline infusion for suppression of preterm labor.
Topics: Captopril; Cardiomyopathies; Digoxin; Echocardiography; Electrocardiography; Female; Furosemide; Hum | 1991 |
[Histological and histochemical studies on the effect of furosemide on rat liver].
Topics: Acid Phosphatase; Adenosine Triphosphatases; Animals; Furosemide; Glycogen; Liver; Male; Necrosis; R | 1988 |
The effect of intraoperative fluid management on the incidence of acute tubular necrosis.
Topics: Furosemide; Graft Survival; Humans; Kidney Transplantation; Kidney Tubules; Mannitol; Necrosis; Repe | 1987 |
[Nephrotoxicity of cefodizime sodium in rats--single and 14-day repeated intravenous administration].
Topics: Animals; Cefazolin; Cefmetazole; Cefotaxime; Cephaloridine; Drug Administration Schedule; Drug Thera | 1988 |
Furosemide and pentobarbital in cryogenic cerebral injury and edema.
Topics: Animals; Brain; Brain Edema; Cerebral Hemorrhage; Drug Synergism; Erythrocytes; Freezing; Furosemide | 1974 |
Hepatic necrosis caused by furosemide.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Furosemide; Injec | 1974 |
Commentary. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity.
Topics: Acetaminophen; Animals; Autoradiography; Benzene Derivatives; Carbon Tetrachloride Poisoning; Carcin | 1974 |
Effect of furosemide on antibiotic-induced renal damage in rats.
Topics: Animals; Anti-Bacterial Agents; Cephaloridine; Cephalothin; Colistin; Female; Furosemide; Glycerol; | 1972 |
[Necroses of the small intestine after administration of potassium].
Topics: Adult; Furosemide; Humans; Intestine, Small; Male; Necrosis; Potassium Chloride | 1966 |