Hepatocyte growth factor activator

A hepatocyte growth factor activator that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q04756]

HGF activator;
HGFA;
EC 3.4.21.-

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
camostat	Homo sapiens (human)	IC50	32.0000	1	1
nafamostat	Homo sapiens (human)	IC50	0.1500	1	1
nafamostat	Homo sapiens (human)	Ki	0.0250	2	2
4-nitrophenyl 4'-guanidinobenzoate	Homo sapiens (human)	IC50	0.8200	1	1
leupeptin	Homo sapiens (human)	Ki	0.1880	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
nafamostat	Homo sapiens (human)	EC50	0.4900	1	1

This protein enables 3 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
serine-type peptidase activity	molecular function	Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
serine-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]

This protein is located in 2 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is active in 2 target(s):

Target	Category	Definition
rough endoplasmic reticulum	cellular component	The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. [ISBN:0198506732]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

This protein is involved in 3 target(s):

Target	Category	Definition
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
blood coagulation	biological process	The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. [PMID:30700128]
zymogen activation	biological process	The proteolytic processing of an inactive enzyme to an active form. [GOC:hjd]