Fructose-1,6-bisphosphatase 1

A fructose-1,6-bisphosphatase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09467]

Synonyms

FBPase 1;
EC 3.1.3.11;
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1;
Liver FBPase

Research

Bioassay Publications (20)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (25.00)	29.6817
2010's	9 (45.00)	24.3611
2020's	6 (30.00)	2.80

Compounds (23)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
rtki cpd	Homo sapiens (human)	IC50	1.3000	1	1
disulfiram	Homo sapiens (human)	IC50	101.2380	10	10
pd 153035	Homo sapiens (human)	IC50	1.0000	1	1
thiram	Homo sapiens (human)	IC50	2.2900	1	1
adenosine monophosphate	Homo sapiens (human)	IC50	2.6436	11	11
bis(1-piperidylthiocarbonyl)disulfide	Homo sapiens (human)	IC50	8.7800	1	1
monosulfiram	Homo sapiens (human)	IC50	10.0000	1	1
dibenzothiazyl disulfide	Homo sapiens (human)	IC50	0.3100	1	1
diphenyl disulfide	Homo sapiens (human)	IC50	10.0000	1	1
aica ribonucleotide	Homo sapiens (human)	IC50	12.0000	1	1
dioxiram	Homo sapiens (human)	IC50	10.0000	1	1
mdl29,951	Homo sapiens (human)	IC50	2.1667	3	3
(+)-usnic acid	Homo sapiens (human)	IC50	371.0000	1	1
1-(4-Methoxyphenyl)-2-nitroethylene	Homo sapiens (human)	IC50	16.0000	1	1
1-phenyl-2-nitropropene	Homo sapiens (human)	IC50	16.0000	1	1
herbacetin	Homo sapiens (human)	IC50	8.7000	1	1
gossypetin	Homo sapiens (human)	IC50	24.0000	1	1
baicalein	Homo sapiens (human)	IC50	29.0000	1	1
scutellarein	Homo sapiens (human)	IC50	38.2000	1	1
beta-nitrostyrene	Homo sapiens (human)	IC50	3.5000	2	2
n,n'-((5-(2-amino-5-(2-methylpropyl)-4-thiazolyl)-2-furanyl)phosphinylidene)bis(alanine) diethyl ester	Homo sapiens (human)	IC50	0.0100	1	1
mb 05032	Homo sapiens (human)	IC50	0.0217	6	6
N-(3-ethynylphenyl)-6,7-dimethoxy-4-quinazolinamine	Homo sapiens (human)	IC50	0.9000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
mb 05032	Homo sapiens (human)	EC50	0.0160	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
aica ribonucleotide	Homo sapiens (human)	ED50	250.0000	1	1
mb 05032	Homo sapiens (human)	Activity	0.0160	1	1

Enables

This protein enables 7 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
AMP binding	molecular function	Binding to AMP, adenosine monophosphate. [GOC:go_curators]
fructose 1,6-bisphosphate 1-phosphatase activity	molecular function	Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. [EC:3.1.3.11]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
monosaccharide binding	molecular function	Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. [GOC:jid]
RNA polymerase II-specific DNA-binding transcription factor binding	molecular function	Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. [GOC:dph, GOC:vw]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 20 target(s):

Target	Category	Definition
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
fructose 6-phosphate metabolic process	biological process	The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism. [ISBN:0198506732]
gluconeogenesis	biological process	The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. [MetaCyc:GLUCONEO-PWY]
regulation of gluconeogenesis	biological process	Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. [GOC:go_curators]
dephosphorylation	biological process	The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. [ISBN:0198506732]
negative regulation of cell growth	biological process	Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
response to nutrient levels	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. [GOC:mah]
cellular response to insulin stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]
negative regulation of glycolytic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis. [GOC:go_curators]
negative regulation of Ras protein signal transduction	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction. [GOC:bf]
cellular response to magnesium ion	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. [GOC:mah]
cellular response to cAMP	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. [GOC:mah]
cellular response to xenobiotic stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:krc, GOC:mah]
cellular hyperosmotic salinity response	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. [GOC:mah]
cellular hypotonic salinity response	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. [GOC:mah]
cellular response to raffinose	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus. [GOC:al]
cellular response to phorbol 13-acetate 12-myristate	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:2200903]
fructose 1,6-bisphosphate metabolic process	biological process	The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis. [ISBN:0198506732]
fructose metabolic process	biological process	The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. [ISBN:0198506732]
sucrose biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside. [GOC:go_curators]