Page last updated: 2024-08-07 18:36:48
Tryptophan 2,3-dioxygenase
A tryptophan 2,3-dioxygenase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48775]
Synonyms
TDO;
EC 1.13.11.11;
Tryptamin 2,3-dioxygenase;
Tryptophan oxygenase;
TO;
TRPO;
Tryptophan pyrrolase;
Tryptophanase
Research
Bioassay Publications (13)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 5 (38.46) | 2.80 |
Compounds (13)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| tryptophan | Homo sapiens (human) | Ki | 11,500.0000 | 1 | 1 |
| chaetochromin | Homo sapiens (human) | IC50 | 48.5500 | 1 | 1 |
| norharman | Homo sapiens (human) | IC50 | 1.2000 | 1 | 1 |
| tryptanthrine | Homo sapiens (human) | IC50 | 1.2935 | 4 | 4 |
| tryptanthrine | Homo sapiens (human) | Ki | 0.5810 | 1 | 1 |
| 4-(2-thiazolylazo)resorcinol | Homo sapiens (human) | IC50 | 43.2800 | 1 | 1 |
| celastrol | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cryptotanshinone | Homo sapiens (human) | IC50 | 9.8000 | 1 | 1 |
| tanshinone ii a | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| nsc 36398 | Homo sapiens (human) | Ki | 16.0000 | 1 | 1 |
| harman | Homo sapiens (human) | IC50 | 6.3100 | 1 | 1 |
| 680c91 | Homo sapiens (human) | IC50 | 0.4693 | 9 | 9 |
| 680c91 | Homo sapiens (human) | Ki | 0.4550 | 2 | 2 |
| beta-3-oxindolylalanine | Homo sapiens (human) | IC50 | 60.2200 | 1 | 1 |
| stf 083010 | Homo sapiens (human) | IC50 | 11.3100 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| tryptophan | Homo sapiens (human) | Km | 167.0000 | 1 | 1 |
Enables
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| tryptophan 2,3-dioxygenase activity | molecular function | Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. [EC:1.13.11.11] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| amino acid binding | molecular function | Binding to an amino acid, organic acids containing one or more amino substituents. [GOC:ai] |
| oxygen binding | molecular function | Binding to oxygen (O2). [GOC:jl] |
| heme binding | molecular function | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| tryptophan catabolic process to kynurenine | biological process | The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine. [GOC:go_curators] |
| protein homotetramerization | biological process | The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. [GOC:go_curators] |
| response to nitroglycerin | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:25626975] |
| tryptophan catabolic process to acetyl-CoA | biological process | The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA. [GOC:go_curators] |