Page last updated: 2024-08-07 18:36:48
Tryptophan 2,3-dioxygenase
A tryptophan 2,3-dioxygenase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48775]
Synonyms
TDO;
EC 1.13.11.11;
Tryptamin 2,3-dioxygenase;
Tryptophan oxygenase;
TO;
TRPO;
Tryptophan pyrrolase;
Tryptophanase
Research
Bioassay Publications (13)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 5 (38.46) | 2.80 |
Compounds (13)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tryptophan | Homo sapiens (human) | Km | 167.0000 | 1 | 1 |
4,6-Substituted-1H-Indazoles as potent IDO1/TDO dual inhibitors.Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives.European journal of medicinal chemistry, , Dec-05, Volume: 160, 2018
Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity.Journal of medicinal chemistry, , 08-25, Volume: 65, Issue:16, 2022
[no title available]Bioorganic & medicinal chemistry, , 06-01, Volume: 39, 2021
Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase.Journal of medicinal chemistry, , 08-12, Volume: 64, Issue:15, 2021
Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase.Bioorganic & medicinal chemistry letters, , 06-01, Volume: 30, Issue:11, 2020
[no title available]Journal of medicinal chemistry, , 10-24, Volume: 62, Issue:20, 2019
Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors.European journal of medicinal chemistry, , Sep-05, Volume: 157, 2018
Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway.Journal of medicinal chemistry, , Nov-25, Volume: 58, Issue:22, 2015
Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles.European journal of medicinal chemistry, , Volume: 54, 2012
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.Journal of medicinal chemistry, , Aug-11, Volume: 54, Issue:15, 2011
Enables
This protein enables 7 target(s):
| Target | Category | Definition |
|---|
| tryptophan 2,3-dioxygenase activity | molecular function | Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. [EC:1.13.11.11] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| amino acid binding | molecular function | Binding to an amino acid, organic acids containing one or more amino substituents. [GOC:ai] |
| oxygen binding | molecular function | Binding to oxygen (O2). [GOC:jl] |
| heme binding | molecular function | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|
| tryptophan catabolic process to kynurenine | biological process | The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine. [GOC:go_curators] |
| protein homotetramerization | biological process | The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. [GOC:go_curators] |
| response to nitroglycerin | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:25626975] |
| tryptophan catabolic process to acetyl-CoA | biological process | The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA. [GOC:go_curators] |