V-type proton ATPase subunit S1

A V-type proton ATPase subunit S1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15904]

Synonyms

V-ATPase subunit S1;
Protein XAP-3;
V-ATPase Ac45 subunit;
V-ATPase S1 accessory protein;
Vacuolar proton pump subunit S1

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bafilomycin a1	Homo sapiens (human)	IC50	0.1000	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
small GTPase binding	molecular function	Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782]
transporter activator activity	molecular function	Binds to and increases the activity of a transporter. [GOC:curators]
ATPase activator activity	molecular function	Binds to and increases the activity of an ATP hydrolysis activity. [GOC:ajp]

Located In

This protein is located in 10 target(s):

Target	Category	Definition
Golgi membrane	cellular component	The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
lysosomal membrane	cellular component	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
endosome membrane	cellular component	The lipid bilayer surrounding an endosome. [GOC:mah]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
clathrin-coated vesicle membrane	cellular component	The lipid bilayer surrounding a clathrin-coated vesicle. [GOC:mah]
synaptic vesicle membrane	cellular component	The lipid bilayer surrounding a synaptic vesicle. [GOC:mah]
endoplasmic reticulum-Golgi intermediate compartment membrane	cellular component	The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system. [GOC:mah, GOC:pr, PMID:16723730]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
proton-transporting V-type ATPase complex	cellular component	A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane. [GOC:mah, ISBN:0716743663, PMID:16449553]
proton-transporting two-sector ATPase complex	cellular component	A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. [GOC:mah, ISBN:0716743663, PMID:16691483]

Involved In

This protein is involved in 12 target(s):

Target	Category	Definition
intracellular iron ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell. [GOC:ai, GOC:mah]
vacuolar acidification	biological process	Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. [GOC:jid]
lysosomal lumen acidification	biological process	Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. [GOC:jid]
osteoclast development	biological process	The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. [CL:0000092, GOC:bf, GOC:yaf]
cellular response to increased oxygen levels	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. [GOC:al]
endosomal lumen acidification	biological process	Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion. [GOC:jid]
intracellular pH reduction	biological process	Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion. [GOC:ai]
Golgi lumen acidification	biological process	Any process that reduces the pH of the Golgi lumen, measured by the concentration of the hydrogen ion. [GOC:dph, PMID:23447592]
synaptic vesicle lumen acidification	biological process	The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading. [GOC:dsf, PMID:21172605, PMID:22875945]
endosome to plasma membrane protein transport	biological process	The directed movement of proteins from the endosome to the plasma membrane in transport vesicles. [GOC:dos]
proton transmembrane transport	biological process	The directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]
regulation of cellular pH	biological process	Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment. [GOC:dph, GOC:mah, GOC:tb]