Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 3821 |
| CHEMBL ID | 742 |
| CHEBI ID | 6121 |
| SCHEMBL ID | 16103 |
| SCHEMBL ID | 17084881 |
| MeSH ID | M0011982 |
| Synonym |
|---|
| smr000238141 |
| MLS001331674 |
| 2-(2-chloro-phenyl)-2-methylamino-cyclohexanone(ketamine) |
| bdbm50044140 |
| 100477-72-3 |
| ketamina |
| ketaminum |
| KBIO1_000217 |
| DIVK1C_000217 |
| 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone |
| ketamine [inn:ban] |
| cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+-)- |
| hsdb 2180 |
| cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)- |
| ketaminum [inn-latin] |
| einecs 229-804-1 |
| nsc 70151 |
| brn 2216965 |
| calypsol |
| special k [street name] |
| cetamina [inn-spanish] |
| nsc70151 |
| ketaject |
| cyclohexanone, (.+-.)- |
| 2-(o-chlorophenyl)-2-(methylamino)cyclohexanone |
| clsta 20 |
| ci 581 base |
| nsc-70151 |
| ketalar base |
| cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)- |
| cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)- |
| dl-ketamine |
| 2-(o-chlorophenyl)-2-(methylamino)-cyclohexanone |
| 2-(methylamino)-2-(2-chlorophenyl)cyclohexanone |
| (+/-)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone |
| cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)- (9ci) |
| special k |
| cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+/-)- (8ci) |
| ketoject |
| cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+/-)- |
| (+/-)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone |
| (+/-)-ketamine |
| ketamine |
| 6740-88-1 |
| C07525 |
| NCGC00159480-03 |
| DB01221 |
| (+-)-ketamine |
| NCGC00159480-02 |
| 2-(2-chloro-phenyl)-2-methylamino-cyclohexanone |
| NINDS_000217 |
| IDI1_000217 |
| anaket v |
| imalgene 1000 |
| vetaket |
| pmi-150 |
| narketan |
| CHEMBL742 , |
| tekam |
| ursotamin |
| clorketam 1000 |
| ketasol 100 |
| chebi:6121 , |
| tekam (tn) |
| D08098 |
| ketamine (inn) |
| 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one |
| dtxsid8023187 , |
| cas-6740-88-1 |
| tox21_111704 |
| tox21_111703 |
| dtxcid703187 |
| HMS2272G05 |
| cetamina |
| unii-690g0d6v8h |
| 690g0d6v8h , |
| ec 229-804-1 |
| ketamine base |
| gtpl4233 |
| ketamine [hsdb] |
| ketafol component ketamine |
| ketamine [inn] |
| ketamine [who-dd] |
| ketamine [mi] |
| ketamine [vandf] |
| SCHEMBL16103 |
| ketanest (salt/mix) |
| vetalar (salt/mix) |
| kalipsol (salt/mix) |
| cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (.+/-.)- |
| ketolar (salt/mix) |
| (.+/-.)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone |
| cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (.+/-.)- |
| 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone # |
| (.+/-.)-ketamine |
| SCHEMBL17084881 |
| J-505587 |
| Q243547 |
| cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)- (9ci) |
| ketaminum (inn-latin) |
| special k (street name) |
| cetamina (inn-spanish) |
| ketaminum (latin) |
| n01ax03 |
Ketamine is a noncompetitive glutamatergic N-methyl-d-aspartate receptor (NMDAR) antagonist that exerts rapid antidepressant effects. Ketamine has sedative, analgesic, and potentially neuroprotective properties.
S(+)-ketamine has a two- to four-fold higher affinity for the phencyclidine receptor of the NMDA receptor complex than ketamine racemate. It is conceivable that the induction of a differentiated pattern of genes induces cellular growth activities via ketamine-mediated NMDA-receptor activation or blockade. Ketamine, 10mg/kg, has a delayed onset but is as effective as 1 mg/kg midazolam for sedating healthy children before ge
Ketamine has been reported to attenuate POCD after cardiac surgery. S-ketamine has neuroprotective properties as a dissociative anaesthetic. Ketamine has emerged as a promising pharmacotherapy for depression.
Ketamine appears to increase catecholamine levels and directly relax bronchial smooth muscle. Ketamine could increase myelination in the mPFC in female rats, but it did not induce learning dysfunction in adulthood; therefore, ketamine may be a safe drug for pediatric anesthesia.
Ketamine is a novel treatment for treatment resistant depression (TRD) Esketamine was approved by the FDA in early 2019. Ketamine treatment was associated with significantly lower NRS scores and morphine doses.
The most common treatment-emergent adverse events associated with ketamine/esketamine are dissociation, anxiety, nausea, increased blood pressure, and headache. Intraoperative ketamine is not associated with an increase in adverse events and may reduce postoperative nausea and vomiting.
The aim of this study was to evaluate the pharmacokinetic variability of S-ketamine in children aged 0-18 years during long-term sedation. Ketamine's half-life of ∼2 h cannot explain antidepressant effects that last for 1 week, suggesting the triggering of long-lasting neuroplasticity.
The present study aimed to investigate the effects of the typical antipsychotic chlorpromazine (CP) alone or combined with the natural antioxidant alpha-lipoic acid (ALA) on changes in the hippocampal average spectral power induced by ketamine (KET)
Sublingual administration of ketamine renders better bioavailability (~30%) and less conversion to norketamine than oral administration. Ketamine lozenges have been shown to have sufficiently high bioavailability to support their use as a preventive treatment in a number of conditions causing intractable neuropathic pain.
| Excerpt | Reference | Relevance |
|---|---|---|
| " We conclude that 5 to 10 mg/kg oral ketamine in water which has a bioavailability of approximately 20% is a useful agent for the preinduction of patients who aggressively refuse medical treatment." | ( [Oral ketamine as preferred preanesthetic medication of uncooperative patients]. Jacobs, FE; Neckel, W; Tolksdorf, W, 1992) | 1.04 |
| " Irradiation at a power density of 60 mW/cm2 (whole-body average specific absorption rate of approximately 14 W/kg) was conducted for sufficient duration to increase colonic temperature from 38." | ( Cardiovascular changes in unanesthetized and ketamine-anesthetized Sprague-Dawley rats exposed to 2.8-GHz radiofrequency radiation. Frei, MR; Jauchem, JR, 1991) | 0.54 |
| " Irradiation was conducted at a power density of 60 mW/cm2 (whole-body average specific absorption rate of 14." | ( Effects of 2.8-GHz microwaves on restrained and ketamine-anesthetized rats. Frei, MR; Jauchem, JR, 1989) | 0.53 |
| " The failure rates of 17% during the preoperative evaluation and 23% during the operation were not negligible and were probably due to the very low bioavailability of ketamine administered orally and the variability of digestive absorption of ketamine from 1 subject to another." | ( [Anesthesia with oral ketamine]. Amadei, B; Amiot, JF; Palacci, JH; Roessler, JG, ) | 0.64 |
| " Intramuscular injection resulted in peak-plasma levels around the twentieth minute, elimination half life was fifty-two minutes, bioavailability 90%." | ( [Comparative study of analgesia and plasma level following rectal, intramuscular and intravenous administration of ketamine]. Erdmann, K; Hilley, D; Jantzen, JP; Klein, AM, 1985) | 0.48 |
| " Diazepam, which produces good tranquilization, is well absorbed when given orally though absorption is influenced by other drugs given at the same time." | ( New drugs--boon or bane? Premedication and intravenous induction agents. Clarke, RS, 1983) | 0.27 |
| " Plasma concentrations of ketamine and norketamine were measured in eight children and revealed a pharmacokinetic pattern indicating comparatively low bioavailability probably due to incomplete absorption from the rectum and a high 'first-pass' metabolism." | ( Rectal ketamine for induction of anaesthesia in children. Holasek, J; Idvall, J; Stenberg, P, 1983) | 1.02 |
| " Absorption after intramuscular injection was rapid and the bioavailability was 93%." | ( Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans. Clements, JA; Grant, IS; Nimmo, WS, 1982) | 0.51 |
| " In the present study, ketamine-anesthetized Sprague-Dawley rats were exposed to 2450-MHz microwaves at an average power density of 60 mW/cm2 (whole-body specific absorption rate of approximately 14 W/kg) until lethal temperatures were attained." | ( Tolazoline decreases survival time during microwave-induced lethal heat stress in anesthetized rats. Chang, KS; Frei, MR; Jauchem, JR, 1996) | 0.6 |
| " Bioavailability is high when it is given parenterally, but low after oral or rectal administration." | ( Ketamine in cancer pain: an update. Mercadante, S, 1996) | 1.74 |
| "22 GHz with a peak specific absorption rate of 420 W/kg and corresponding incident power density of 15 mW/cm2 for 15 min or sham-exposed." | ( Electromagnetic millimeter waves increase the duration of anaesthesia caused by ketamine and chloral hydrate in mice. Rojavin, MA; Ziskin, MC, 1997) | 0.52 |
| "The present study was designed to evaluate the oral efficacy and bioavailability of ketamine." | ( Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine. Elliott, KJ; Gorman, AL; Inturrisi, CE; Shimoyama, M; Shimoyama, N, 1999) | 1.04 |
| " Ketamine-anesthetized male Sprague-Dawley rats (n = 58) were exposed individually to one of three conditions: 1-GHz, 10-GHz, or combined 1- and 10-GHz MWs at an equivalent whole-body specific absorption rate of 12 W/kg." | ( Cardiovascular and thermal effects of microwave irradiation at 1 and/or 10 GHz in anesthetized rats. Frei, MR; Jauchem, JR; Ryan, KL, 2000) | 1.22 |
| "The quantitative structure-bioavailability relationship of 232 structurally diverse drugs was studied to evaluate the feasibility of constructing a predictive model for the human oral bioavailability of prospective new medicinal agents." | ( QSAR model for drug human oral bioavailability. Topliss, JG; Yoshida, F, 2000) | 0.31 |
| " Furthermore, the stability (chemical and metabolic) and bioavailability of radiopharmaceuticals have in general proved to be a challenge during development and clinical administration." | ( Effect of cyclodextrin complexation on the in vivo disposition of the brain imaging radiopharmaceutical 99mTechnetium ethyl cysteinate dimer (99mTc-ECD). de Beco, V; Dormehl, IC; Kilian, E; Louw, W; Morretti, JL; Oliver, DW, 2000) | 0.31 |
| " The bioavailability of the tablet was estimated to be approximately 20%; the area under the plasma concentration-time curve, (AUC)(0-->8 h), of norketamine was approximately 500 ng h/ml in both enantiomers." | ( Plasma concentration profiles of ketamine and norketamine after administration of various ketamine preparations to healthy Japanese volunteers. Aoyama, T; Ashizawa, N; Hiraishi, T; Iga, T; Kariya, S; Ohtani, M; Uchino, K; Yamada, Y; Yamamura, Y; Yanagihara, Y, 2003) | 0.8 |
| " The KET absorption rate was also increased in PCM rats." | ( Effects of protein calorie malnutrition on the pharmacokinetics of ketamine in rats. Gudi, G; Mager, DE; Mulheran, M; Parenteau, H; Tracy, TS; Wainer, IW; Williams, ML, 2004) | 0.56 |
| " All three enzymes enhanced the absorption rate of xylazine and ketamine determined by measurement of the concentration in the perfusate." | ( [Use of hyaluronic acid cleaving enzymes for absorption acceleration. Results of an in vitro study with xylazine and ketamine]. Gross, C; Kietzmann, M, 2006) | 0.78 |
| " The objective of the study was to develop a lozenge formulation of ketamine for use in patients with neuropathic pain, and to investigate its storage stability and bioavailability after oral or sublingual administration." | ( Development of a sublingual/oral formulation of ketamine for use in neuropathic pain: Preliminary findings from a three-way randomized, crossover study. Chong, C; Ilett, KF; Jenkins, B; Page-Sharp, M; Schug, SA, 2009) | 0.84 |
| " Bioavailability after both oral and sublingual administration was evaluated in six patients with chronic neuropathic pain." | ( Development of a sublingual/oral formulation of ketamine for use in neuropathic pain: Preliminary findings from a three-way randomized, crossover study. Chong, C; Ilett, KF; Jenkins, B; Page-Sharp, M; Schug, SA, 2009) | 0.61 |
| " Bioavailability was sufficiently high and reproducible to support its use in routine pain management." | ( Development of a sublingual/oral formulation of ketamine for use in neuropathic pain: Preliminary findings from a three-way randomized, crossover study. Chong, C; Ilett, KF; Jenkins, B; Page-Sharp, M; Schug, SA, 2009) | 0.61 |
| " In this case, the drug administration per os in the form of a tabletization mixture with poly(vinyl pyrrolidone) and lactose was more effective compared to a mixture of the parent substance with Tween-80, which can be explained by the favorable effect of additives on the bioavailability of dilept." | ( [Neurotensine dipeptide analog dilept decreases the deficiency of prestimulus startle reflex inhibition: a prognostic sign of antipsychotic activity]. Gudasheva, TA; Krupina, NA; Ostrovskaia, RU; Seredenin, SB; Voronina, TA, ) | 0.13 |
| " There is low relative bioavailability (<0." | ( Exploring the pharmacokinetics of oral ketamine in children undergoing burns procedures. Anderson, BJ; Brunette, KE; Herd, DW; Schulein, S; Thomas, J; Wiesner, L, 2011) | 0.64 |
| " Sublingual administration of ketamine renders better bioavailability (~30%) and less conversion to norketamine than oral administration." | ( Antidepressant, mood stabilizing and procognitive effects of very low dose sublingual ketamine in refractory unipolar and bipolar depression. Bisol, LW; Lara, DR; Munari, LR, 2013) | 0.9 |
| " The bioavailability of sufentanil and ketamine was 24." | ( Intranasal sufentanil/ketamine analgesia in children. Anderson, BJ; Ferreirós, N; Friis, SM; Henneberg, SW; Labocha, S; Nielsen, BN; Rømsing, J; Schmiegelow, K, 2014) | 0.99 |
| " Quinidine, a cytochrome P450 (CYP) 2D6 inhibitor, was also evaluated in conjunction with dextromethorphan to increase the bioavailability of dextromethorphan and reduce exposure to additional metabolites." | ( Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan. Healy, JR; Matsumoto, RR; Nguyen, L; Robson, MJ; Scandinaro, AL, 2014) | 0.4 |
| "The principal study objective was to investigate the pharmacokinetic characteristics of a new sublingual ketamine wafer and to establish its absolute bioavailability and local tolerability." | ( The absolute bioavailability of racemic ketamine from a novel sublingual formulation. Lim, S; Liu, Y; Molnar, V; Rolan, P; Sunderland, V, 2014) | 0.88 |
| "The median (90% CI lower, upper limit) absolute bioavailability of sublingual ketamine was 29% (27, 31%)." | ( The absolute bioavailability of racemic ketamine from a novel sublingual formulation. Lim, S; Liu, Y; Molnar, V; Rolan, P; Sunderland, V, 2014) | 0.9 |
| " The ketamine wafer has comparable bioavailability with other oral transmucosal formulations of ketamine but with markedly reduced inter-subject variability, warranting further evaluation as an analgesic adjunct." | ( The absolute bioavailability of racemic ketamine from a novel sublingual formulation. Lim, S; Liu, Y; Molnar, V; Rolan, P; Sunderland, V, 2014) | 1.18 |
| " The oral bioavailability of S-ketamine was low, 8% (11% interindividual variability), and its clearance was high, 95 L/h/70 kg (13% interindividual variability)." | ( Population pharmacokinetics of S-ketamine and norketamine in healthy volunteers after intravenous and oral dosing. Backman, JT; Fanta, S; Kalso, E; Kinnunen, M, 2015) | 0.98 |
| " Bioavailability after oral administration vs." | ( Drug Pharmacokinetics Determined by Real-Time Analysis of Mouse Breath. Bregy, L; Brown, SA; Dallmann, R; Detmar, M; Hollmén, M; Kohler, M; Li, X; Martinez-Lozano Sinues, P; Proulx, S; Zenobi, R, 2015) | 0.42 |
| " Because of extensive first-pass metabolism, oral bioavailability is poor and ketamine is vulnerable to pharmacokinetic drug interactions." | ( Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. Hagelberg, NM; Olkkola, KT; Peltoniemi, MA; Saari, TI, 2016) | 2.11 |
| "Cell membrane permeability is an important determinant for oral absorption and bioavailability of a drug molecule." | ( Highly predictive and interpretable models for PAMPA permeability. Jadhav, A; Kerns, E; Nguyen, K; Shah, P; Sun, H; Xu, X; Yan, Z; Yu, KR, 2017) | 0.46 |
| " Although the reduction in dose-independent bioavailability is best explained by retention of drug and particle exhalation, the reduction in dose-dependent bioavailability is probably due to sedation-related loss of drug into the air." | ( Pharmacokinetics and Bioavailability of Inhaled Esketamine in Healthy Volunteers. Aarts, L; Dahan, A; Duma, A; Henthorn, T; Jonkman, K; Mooren, R; Niesters, M; Olofsen, E; Siebers, L; van den Beukel, J; van Velzen, M, 2017) | 0.71 |
| " The use of MAD even gives as better bioavailability of drugs." | ( Intranasal drug administration for procedural sedation in children admitted to pediatric Emergency Room. Chiaretti, A; Fabrizio, GC; Fantacci, C; Ferrara, P; Franceschi, F, 2018) | 0.48 |
| " Oral bioavailability is low and erratic, limiting application of this route for chronic use." | ( Intranasal Ketamine and Its Potential Role in Cancer-Related Pain. Gillespie, TW; Harvey, RD; Singh, V, 2018) | 0.87 |
| " The PK data demonstrated a significantly increased oral bioavailability and serum exposure of ketamine in dKO > Pgp KO > Bcrp KO mice compared with WT mice." | ( Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice. Ganguly, S; Panetta, JC; Roberts, JK; Schuetz, EG, 2018) | 2.14 |
| " Ketamine response resulted in more pronounced effects in the kynurenine pathway and the arginine pathway at 4 h post-infusion, where a larger decrease in circulating kynurenine levels and a larger increase in the bioavailability of arginine were observed in responders to ketamine treatment, suggesting possible mechanisms for response to ketamine treatment." | ( Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects. Ferrucci, L; Gould, TD; Kadriu, B; Khadeer, M; Lovett, J; Moaddel, R; Morris, PJ; Ravichandran, S; Shardell, M; Thomas, CJ; Yuan, P; Zarate, CA, 2018) | 1.67 |
| " The bioavailability of oral ketamine and interindividual variations thereof have been poorly studied; possibly only 20%-25% of an oral dose reaches the bloodstream." | ( Oral Ketamine for Depression, 1: Pharmacologic Considerations and Clinical Evidence. Andrade, C, 2019) | 1.32 |
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
| " Therefore, this study aimed to examine the pharmacokinetics, absolute bioavailability and tolerability of intranasal ketamine administration compared with intravenous administration." | ( Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs. Croubels, S; Devreese, M; Dockx, R; Duchateau, L; Peremans, K; Polis, I; Vlerick, L, 2020) | 1.01 |
| " Recently, ketamine lozenges have been shown to have sufficiently high bioavailability to support their use as a preventive treatment in a number of conditions causing intractable neuropathic pain." | ( Ketamine as a potential option in the treatment of short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing. Aggarwal, A, ) | 1.96 |
| " Preanesthetic oral ketamine is generally used in children but has less bioavailability due to the first-pass effect." | ( Preanesthetic nebulized ketamine vs preanesthetic oral ketamine for sedation and postoperative pain management in children for elective surgery: A retrospective analysis for effectiveness and safety. Chen, C; Cheng, X; Fu, F; Lin, L, 2021) | 1.25 |
| " The nebulised route of drug delivery carries the advantage of good bioavailability and safety profile." | ( Comparison of single-shot nebuliser protocol between dexmedetomidine and ketamine in children undergoing magnetic resonance imaging. Geetha, K; Karishma, K; Padhy, S, 2022) | 0.95 |
| " However, the poor bioavailability of curcumin is a significant pharmacological barrier for its antioxidant activities." | ( Neuroprotective effects of curcumin-loaded nanophytosome on ketamine-induced schizophrenia-like behaviors and oxidative damage in male mice. Bavaghar, B; Maboudi, K; Moghaddam, AH; Sangdehi, SRM; Zare, M, 2021) | 0.86 |
| " Esketamine showed a clinically relevant pharmacokinetic profile, with high bioavailability (62%) and relatively low maximum concentration peaks." | ( Esketamine inhaled as dry powder: Pharmacokinetic, pharmacodynamic and safety assessment in a preclinical study. Abramski, K; Dera, P; Gajos-Draus, A; Janicka, M; Janowska, S; Kamil, K; Mach, M; Matłoka, M; Moszczyński-Pętkowski, R; Pankiewicz, P; Perko, P; Pieczykolan, J; Teska-Kamińska, M; Tratkiewicz, E; Wieczorek, M; Ziółkowski, H, 2022) | 2.06 |
| " When the delayed dissolution rate was used to fit the oral data, the estimated bioavailability was nearly identical to that obtained with the full model." | ( Relationship Between Dissolution Rate in Vitro and Absorption Rate in Vivo of Ketamine Prolonged-Release Tablets. Weiss, M, 2023) | 1.14 |
| "A comparison of the time course of the absorption rate with that of the dissolution rate can reveal more details of the absorption process." | ( Relationship Between Dissolution Rate in Vitro and Absorption Rate in Vivo of Ketamine Prolonged-Release Tablets. Weiss, M, 2023) | 1.14 |
| " In rats, compound 7k had better pharmacokinetic properties and oral bioavailability (F = 67." | ( 3,4-Dihydrobenzo[e][1,2,3]oxathiazine 2,2-dioxide analogs act as potential AMPA receptor potentiators with antidepressant activity. Deng, W; Guo, W; Hu, X; Li, T; Luo, X; Ma, X; Ni, P; Qi, X; Wang, Q; Wei, L; Wei, Y; Yu, X; Zhao, L; Zheng, Y, 2023) | 0.91 |
| "Absorption of ketamine is rapid though the rate of uptake and bioavailability is determined by the route of exposure." | ( The clinical toxicology of ketamine. Gee, P; Mackenzie, E; Schep, LJ; Slaughter, RJ; Watts, M, 2023) | 1.57 |
| " Despite bioavailability and peak plasma concentrations both being lower than when administered parenterally, evidence suggests that low-dose oral ketamine is clinically effective in treating pain." | ( Oral ketamine may offer a solution to the ketamine conundrum. Can, AT; Dutton, M; Hermens, DF; Lagopoulos, J, 2023) | 1.62 |
Methamphetamine (4mg/kg)-induced place preference mice model was successfully established. ketamine (15mg/ kg), rhynchophylline (40mg/ kilo) and rhyn chophyllin (80mg/kilo) can eliminate place preference. The number of NR2B-positive neurons in hippocampus was increased in the methamphetamine model group, whereas less NR2b- positive neurons were found in the ketamine group, low and high dosage rhyn Chophiline group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dosage of ketamine was 2 mg/kg body weight, supplemented if necessary by 1 mg/kg, in combination with either 2 mg flunitrazepam or placebo." | ( Reduction of psychotomimetic side effects of Ketalar (ketamine) by Rohypnol (flunitrazepam). A randomized, double-blind trial. Freuchen, I; Kühl, JB; Mikkelsen, BO; Ostergaard, J, 1976) | 0.86 |
| " To evaluate this possibility, the authors devised a technique for determining the minimal arrhythmic dosage of epinephrine that permitted graded assessment of changes in the sensitivity of the heart to epinephrine-induced arrhythmias." | ( Effects of pharmacologic alterations of adrenergic mechanisms by cocaine, tropolone, aminophylline, and ketamine on epinephrine-induced arrhythmias during halothane-nitrous oxide anesthesia. Koehntop, DE; Liao, JC; Van Bergen, FH, 1977) | 0.47 |
| " There was no significant difference between the mothers and babies in the three meperidine dosage groups for maternal parity, maternal age, birth weight, number of forceps deliveries or duration of labour." | ( Double-blind comparison of the neurobehaviour of neonates following the administration of different doses of meperidine to the mother. Bhatt, M; Hodgkinson, R; Wang, CN, 1978) | 0.26 |
| "A procedure is described which allows chronic dosing and blood collection from awake monkeys." | ( Chronic intravenous dosing and blood collection in the unanesthetized monkey. Bedford, JA; Kibbe, AH; Wilson, MC, 1977) | 0.26 |
| " A minimal effective dosage of 90 mg/kg for ketamine and 10 mg/kg for xylazine provided satisfactory anesthesia in 92% of the subjects, without adverse effects on gestation or the fetuses." | ( Ketamine/xylazine anesthesia in the pregnant rat. Stickrod, G, 1979) | 1.96 |
| " The duration of sleep, determined by failure of the animals to right themselves, was then used to construct dose-response curves for the two drugs in the hyperbaric environments." | ( Ketamine and thiopental sleep responses in guinea pigs in hyperbaric helium-oxygen. Bailey, RC; McCracken, LE; Nicodemus, HF; Tobey, RE, 1979) | 1.7 |
| " Both drugs were suitable and three dogs immobilized with ketamine HCl at a dosage rate of 7 mg/kg had smoother and shorter recovery periods than the three animals immobilized with phencyclidine HCl." | ( The restraint of the Cape Hunting dog Lycaon pictus with phencyclidine hydrochloride and ketamine hydrochloride. Ebedes, H; Grobler, M, 1979) | 0.73 |
| " Dose-response curves were obtained using mice at pressures ranging from 1 to 125 atm for five agents, namely alpha-chloralose, ethylcarbamate, phenobarbital and, for comparison, nitrogen and argon." | ( The pressure reversal of a variety of anesthetic agents in mice. Miller, KW; Wilson, MW, 1978) | 0.26 |
| " The amount of ketamine required for anaesthesia has been analysed in detail and recommendations on dosage are given." | ( Ketamine infusions. Observations on technique, dosage and cardiovascular effects. Dundee, JW; Lilburn, JK; Moore, J, 1978) | 2.05 |
| "Five anesthetic agents (C1744, etorphine, fentanyl, ketamine hydrochloride, and halothane) were tested to establish the dosage of a safe, effective, short-acting anesthetic for use in the sea otter." | ( Comparison of anesthetic agents in the sea otter. Kocher, FH; Williams, TD, 1978) | 0.51 |
| " We used a combination of droperidol and fentanyl as premedication in low dosage to obtain a maximal efficiency of the possibly minimal medication of intravenously injected ketamine." | ( [General anaesthesia with ketamine for electro-cochleography in children (author's transl)]. Innitzer, J; Schmid, E, 1977) | 0.75 |
| " It is suggested that ketamine should be re-evaluated, using a lower dosage schedule, for Caesarean section." | ( Ketamine for anaesthetic induction at Caesarean section. Allen, PJ; Downing, JW; Jeal, DE; Mahomedy, MC, 1976) | 2.01 |
| " Change in anesthesiologists may have been a factor in increasing apprehension and anesthetic dosage in later treatments." | ( Low-dose intramuscular ketamine for pediatric radiotherapy: a case report. Amberg, HL; Gordon, G, ) | 0.44 |
| " Parenteral administration of ketamine, at the dosage rate studied, quickly produced an immobilizing effect of variable duration (0." | ( Disposition kinetics of ketamine in the domestic cat. Baggot, JD; Blake, JW, 1976) | 0.85 |
| " Ketamine produced significant decreases in contractility and there were some indications of a dose-response pattern." | ( Effects of ketamine on canine cardiovascular function. Beer, N; Bello, A; Bianco, JA; Diaz, FA; Izquierdo, JP; Jaen, R; Velarde, H, 1976) | 1.56 |
| " Consistent results have been obtained with a dosage related to the metabolic rate of the child." | ( Anaesthesia for electrocochleography. Hutton, JN, 1976) | 0.26 |
| " With regard to the dosage and method of administration, ketamine was shown to be less effective than morphine for the first 3 hours postoperatively, but equally effective subsequently, whereas the patients who received ketamine showed a greater progressive tendency for their respiratory parameters to improve with time." | ( Intravenous ketamine for postoperative analgesia. Clausen, L; Sinclair, DM; Van Hasselt, CH, 1975) | 0.88 |
| " Linear dose effect curves relating discriminability (sessions to criterion) to dosage were obtained with all three drugs." | ( A comparison of the discriminable CNS effects of ketamine, phencyclidine and pentobarbital. Overton, DA, 1975) | 0.51 |
| "In a comparison of digitalis tolerance in dogs anesthetized with ketamine, Innovar Vet, or pentobarbital, the dosage of ouabain needed to cause ventricular tachycardia was significantly higher, as was the LD50 of ouabain, with ketamine or Innovar than with pentobarbital." | ( The effects of ketamine and of Innovar anesthesia on digitalis tolerance in dogs. El-Etr, AA; Ivankovich, AD; Janeczko, GF; Maronic, JP, ) | 0.72 |
| " The doses of the anasthetic agents were selected from the dose-response experiments." | ( Effect of lithium and rubidium on the sleeping time caused by various intravenous anaesthetics in the mouse. Männistö, PT; Saarnivaara, L, 1976) | 0.26 |
| " A dose of 300 mg/kg of NMDA significantly shifted the dose-response curve of ketamine for loss of righting reflex to the right." | ( Ketamine-induced anesthesia involves the N-methyl-D-aspartate receptor-channel complex in mice. Fukuda, T; Irifune, M; Nomoto, M; Shimizu, T, 1992) | 1.95 |
| " In order to evaluate the anaesthetic and antinociceptive properties of S(+)-ketamine, a dose-response relationship of the compound on the EEG, somatosensory-evoked potentials (SEP), and respiration was established." | ( [Pharmacodynamic effects of S-(+)-ketamine on EEG, evoked potentials and respiration. A study in the awake dog]. Freye, E; Latasch, L; Schmidhammer, H, 1992) | 0.79 |
| "2% isoflurane for general surgical procedures; and for electrophysiological recordings in the eighth nerve we recommend barbiturate anesthesia of appropriate dosage in combination if possible with an opioid agent to provide additional analgesic action." | ( A comparison of anesthetic agents and their effects on the response properties of the peripheral auditory system. Capranica, RR; Dodd, F, 1992) | 0.28 |
| " If dosage is kept low, the rate of recovery is acceptable, and some of the drugs commonly used in the regimen with ketamine are reversible with appropriate antagonists." | ( Advantages and guidelines for using ketamine for induction of anesthesia. Hartsfield, SM, 1992) | 0.77 |
| " Dose-response curves for thiopentone, ketamine and their combinations were determined with a probit procedure and compared with isobolographic analysis." | ( Anaesthetic interaction between thiopentone and ketamine. Bradley, EL; Gesztes, T; Katz, J; Kissin, I; Roytblat, L; Rozentsveig, V, 1992) | 0.81 |
| " Although this dosing regimen produced the desired anaesthetic effects, it caused untoward cardiopulmonary effects." | ( Physiological responses of sheep to two hours anaesthesia with diazepam-ketamine. Coulson, NM; Januszkiewicz, AJ; Ripple, GR, 1991) | 0.51 |
| " Five 2-year-old male Macaca fuscata monkeys were given rectal ketamine at a dosage of 60 mg/kg and 90 mg/kg one week apart." | ( Conscious sedation and analgesia with rectal ketamine in the Macaca fuscata monkey. Bellinger, L; Harris, M; Seale, NS; Steelman, R; Wagner, M; Williams, F, ) | 0.63 |
| " An examination of the descending limb of the dose-response functions revealed that lowered response rates for cocaine and ketamine were correlated with increases in run time and small and inconsistent effects on postreinforcement pause time." | ( Analysis of fixed-ratio behavior maintained by drug reinforcers. Skjoldager, P; Winger, G; Woods, JH, 1991) | 0.49 |
| " When YOH was used as an anesthetic antagonist at dosage of 20 mg/kg, 20% mortality was observed and was attributable to acute respiratory arrest." | ( Antagonism of ketamine-xylazine anesthesia in rats by administration of yohimbine, tolazoline, or 4-aminopyridine. Komulainen, A; Olson, ME, 1991) | 0.64 |
| " During the course of the study, mean catecholamine dosage increased significantly in the fentanyl group from 12." | ( [The use of ketamine and midazolam for analgesia and sedation in ventilated patients subject to obligatory treatment with catecholamines]. Adams, HA; Biscoping, J; Claussen, E; Gebhardt, B; Hempelmann, G, 1991) | 0.66 |
| " Guaifenesin amplifies the effect of several anaesthetics, which complement one another, allowing the dosage to be decreased and thereby reducing the cardiovascular stress." | ( [Combination anesthesia in sheep with ketamine-(fentanyl)-guaifenesin (My 301)-laughing gas-halothane]. Blättchen, C; Blümel, G; Brosch, W; Erhardt, W; Roder, J; Schindele, M, 1990) | 0.55 |
| " Perturbed recovery from ketamine anaesthesia might be largely prevented by psychological preoperative preparation and adequate dosage of the benzodiazepine used for premedication." | ( [Ketamine infusion in tympanoplasty]. Gregoriades, S, 1990) | 1.49 |
| " Ketamine, 3 X 10(-4) M, produced a shift to the right of the dose-response curve without altering the maximum contractile responses to carbachol, but had no effect on dose-response curves to substance P, the putative noncholinergic transmitter in these bronchial segments." | ( Differential effect of ketamine on cholinergic- and noncholinergic-induced contractions of isolated guinea-pig bronchi. Brunson, DB; Buckner, CK; Laravuso, RB; Leblanc, PH; Will, JA, 1987) | 1.49 |
| " With increasing ketamine concentration (5 x 10(-5)-10(-3) mol l-1), the amplitude of glutamate potentials was reduced and dose-response curves for ionophoresis of L-glutamate were shifted to the right, particularly after concanavalin A treatment." | ( Enhancement of desensitization of quisqualate-type glutamate receptor by the dissociative anaesthetic ketamine. Ashford, ML; Boden, P; Ramsey, RL; Usherwood, PN, 1989) | 0.83 |
| " Ketamine was injected peritoneally in dosage of 4 mg/kg and 20 mg/kg respectively." | ( [Effect of ketamine on acupuncture analgesia]. Chen, ZQ; Xu, W; Yan, YS, 1989) | 1.58 |
| " The above parameters as well as mean arterial blood pressure, righting, palpebral, pedal, and jaw reflexes were monitored ten minutes after the intramuscularly administered dosage and throughout 4 hours of infusion." | ( The effects of prolonged ketamine-xylazine intravenous infusion on arterial blood pH, blood gases, mean arterial blood pressure, heart and respiratory rates, rectal temperature and reflexes in the rabbit. Richardson, ME; Scott, RA; Wyatt, JD, 1989) | 0.58 |
| " Using a dosage of 3-5 mg/kg there is a marked negative effect on the cardio-vascular system." | ( [The antagonism of ketamine/xylazine anesthesia ("Hellabrunn mixture") in wild zoo ruminants]. Erhardt, W; Hafner, S; Halm, S; von Hegel, G; Wiesner, H, 1989) | 0.61 |
| " Dosage requirements for anesthetic agents are shown." | ( Fentanyl-midazolam-flumazenil anesthesia for induced abortion. Garamvölgyi, G; Hamar, O; Kálmán, A, 1989) | 0.28 |
| "The systemic administration of an anesthetic dosage of a combination of xylazine and ketamine hydrochloride produced an acute exposure keratopathy which progressed into a syndrome resembling keratoconjunctivitis sicca." | ( Keratoconjunctivitis sicca with associated secondary uveitis elicited in rats after systemic xylazine/ketamine anesthesia. Fox, A; Kufoy, EA; Pakalnis, VA; Parks, CD; Wells, A; Yang, CH, 1989) | 0.72 |
| " CGS 19755 was studied using single and cumulative dosing procedures up to a dose of 10." | ( The competitive N-methyl-D-aspartate (NMDA) antagonist CGS 19755 attenuates the rate-decreasing effects of NMDA in rhesus monkeys without producing ketamine-like discriminative stimulus effects. France, CP; Ornstein, P; Woods, JH, 1989) | 0.48 |
| " Experimental conditions provided several different doses of drug during each of two daily 130 min sessions; as a result, a dose-response curve relating rate of responding to dose/injection for self-administered drug was obtained within each session." | ( Drug-reinforced responding: rapid determination of dose-response functions. Palmer, RK; Winger, G; Woods, JH, 1989) | 0.28 |
| " The low dosage reduced total AD accrued during each kindling stage but failed to alter kindling rate." | ( The NMDA-receptor antagonist, MK-801, suppresses limbic kindling and kindled seizures. Gilbert, ME, 1988) | 0.27 |
| " In this preparation, all these antagonists shifted the NMDA dose-response curve to the right in a parallel manner." | ( Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex. Harrison, NL; Simmonds, MA, 1985) | 0.27 |
| " The dose-response curves for phencylidine and ketamine were shifted to the right in the presence of TRH (0." | ( Effects of thyrotropin-releasing hormone on phencyclidine- and ketamine-induced spinal depression in neonatal rats. Ohno, Y; Warnick, JE, 1988) | 0.77 |
| " However, the slope of midazolam's dose-response curve for sedation appeared to be steeper (i." | ( Comparison of midazolam and diazepam for sedation during plastic surgery. Mathes, SA; Vasconez, LO; Way, WL; Wender, LA; White, PF, 1988) | 0.27 |
| "The purpose of this article is to document that ketamine hydrochloride, administered at an anesthetic dosage of about 100 mg/kg, produces tongue contractile activity in the rat." | ( Ketamine as a pharmacological model for tongue dyskinesia. Aldes, LD; Chronister, RB; Marco, LA; Prater, SR, 1988) | 1.97 |
| " The dosage of anesthetic agents was calculated according to body weight." | ( [Combined midazolam-ketamine anesthesia in traumatologic interventions. Patterns of endocrine reactions]. Bornscheuer, A; Hamkens, A; Lübbe, N; Seitz, W, 1988) | 0.6 |
| "Ten dogs were studied to determine the effects of xylazine, ketamine, and xylazine combined with ketamine on the dosage of epinephrine required to produce ventricular arrhythmia." | ( Effects of xylazine and ketamine on epinephrine-induced arrhythmia in the dog. Heath, RB; Wingfield, WE; Wright, M, ) | 0.68 |
| " Generally, an orderly inverted U-shaped dose-response curve for rates of self-injection has been observed." | ( Animal models of intravenous phencyclinoid self-administration. Marquis, KL; Moreton, JE, 1987) | 0.27 |
| " A solution of 5% guaifenesin in 5% dextrose given intravenously at a dosage of 200 mg/kg, abolished the pedal, palpebral and corneal reflexes for up to 15 minutes with little influence on cardiopulmonary function." | ( Guaifenesin alone or in combination with ketamine or sodium pentobarbital as an anesthetic in rabbits. McCabe, K; Olson, ME; Walker, RL, 1987) | 0.54 |
| " This study, performed with a noninvasive respiratory monitoring technique, confirms that droperidol infused over 5 min at a clinically used dosage does not cause respiratory depression in healthy subjects, whereas ketamine produces an important ventilatory stimulation." | ( Noninvasive evaluation of breathing pattern and thoraco-abdominal motion following the infusion of ketamine or droperidol in humans. Forster, A; Gemperle, M; Morel, DR, 1986) | 0.67 |
| " The non-parallel shift of the NMDA dose-response curve suggests that ketamine is not acting as a competitive antagonist of NMDA." | ( Effect of ketamine on amino acid-evoked release of acetylcholine from rat cerebral cortex in vitro. Johnston, GA; Lodge, D, 1985) | 0.91 |
| " The degree of drug tolerance was assessed by determining cumulative dose-response functions for morphine before, during and after chronic administration." | ( Modification of morphine tolerance by behavioral variables. Sannerud, CA; Young, AM, 1986) | 0.27 |
| " Ten animals received the same dosage of indomethacin beginning 2 h after the start of endotoxin infusion." | ( Prophylactic and delayed treatment with indomethacin in a porcine model of early adult respiratory distress syndrome induced by endotoxaemia. Borg, T; Gerdin, B; Modig, J, 1986) | 0.27 |
| " The dosage rates of the immobilization combinations for mammmals, birds and reptiles are presented in tabular form." | ( [Practical advice concerning the immobilization of wild and zoo animals]. von Hegel, G; Wiesner, H, 1985) | 0.27 |
| "Ketamine, ketamine-xylazine, and ketamine-diazepam were evaluated clinically in 15 ferrets, and safe dosage was determined for each." | ( Evaluation of ketamine, ketamine-xylazine and ketamine-diazepam anesthesia in the ferret. Glaser, C; Moreland, AF, 1985) | 2.07 |
| "1 to 1 mM) or verapamil (3 to 30 nM) induced parallel, concentration-dependent rightward displacements of the dose-response curves to Ca2+ (0." | ( Ketamine-inhibition of calcium-induced contractions in depolarized rat uterus: a comparison with other calcium antagonists. Calixto, JB; Loch, S, 1985) | 1.71 |
| "The dose-response curves of vecuronium and pancuronium were compared during ketamine anaesthesia in 60 patients (ASA I)." | ( Dose-response relationships and neuromuscular blocking effects of vecuronium pancuronium during ketamine anaesthesia. Engbaek, J; Ording, H; Pedersen, T; Viby-Mogensen, J, 1984) | 0.72 |
| " The first five received varying doses from 5 to 50 mg in a volume of 3 ml of 5% dextrose, to determine a dose-response curve (Group 1)." | ( Intrathecal ketamine for war surgery. A preliminary study under field conditions. Bion, JF, 1984) | 0.65 |
| "The dose-response effects of ketamine, an intravenous anesthetic with psychotomimetic properties which is a ketone derivative of phencyclidine, were evaluated in several experimental animal models of aggression." | ( Effects of ketamine on experimental animal models of aggression. Monteiro-de-Lima, TC; Morato, GS; Takahashi, RN, 1984) | 0.95 |
| " The dosage of 1 mg/kg however was followed by a transient impairment of the levels of consciousness." | ( [Intramuscular ketamine analgesia in emergency patients. I. Clinico--pharmacokinetic study]. Dick, W; Hirlinger, WK; Knoche, E, 1983) | 0.62 |
| " min-1) significantly decreases the drug dosage requirement, improves intraoperative conditions, and decreases recovery time compared with the traditional intermittent bolus technique." | ( Use of continuous infusion versus intermittent bolus administration of fentanyl or ketamine during outpatient anesthesia. White, PF, 1983) | 0.49 |
| " Log-probit dose-response curves of the inhibitory effects of the anesthetics on the catecholamine releases induced by acetylcholine, nicotine, and muscarine were determined." | ( Selective actions of intravenous anesthetics on nicotinic- and muscarinic-receptor-mediated responses of the dog adrenal medulla. Amakata, Y; Amenomori, Y; Hirano, H; Matsumoto, T; Sumikawa, K, 1983) | 0.27 |
| "The action of ketamine on intracranial pressure in the presence of haemorrhagic shock, at both the dosage levels used for emergency cases and for in-patient treatment, was investigated using an animal model." | ( [Animal experiment study on intracranial pressure, after ketamine administration]. Dick, W; Grünert, A; Lotz, P; Pfenninger, E, 1984) | 0.87 |
| " Dose-response curves and median effective doses were determined for phencyclidine, N-ethyl-1-phenylcyclohexylamine, 1-(1-(2-thienyl) cyclohexyl) piperidine and ketamine." | ( Comparison of phencyclidine and three analogues on fixed-interval performance in rhesus monkeys. Balster, RL; Brady, KT; Meltzer, LT; Schwertz, D, 1980) | 0.46 |
| " When rates and patterns of responding reached stability, dose-response curves for phencyclidine (0." | ( Tolerance to phencyclidine in pigeons: cross-tolerance to ketamine. Wenger, GR, 1983) | 0.51 |
| " Little dose-response effect was evident for any of the drugs." | ( Alteration of renal hemodynamics by thiopental, diazepam, and ketamine in conscious dogs. Priano, LL, 1982) | 0.5 |
| " After reliable discriminative control of lever choice was established, dose-response determinations for generalization to the training dose of PCP were made with several doses of PCP, a racemic mixture of ketamine and the pure levo (-) and dextro (+) salts of ketamine." | ( Discriminative stimulus properties of ketamine stereoisomers in phencyclidine-trained rats. Balster, RL; Brady, KT, 1982) | 0.72 |
| " ketamine infusion, mean dosage 39 micrograms/kg/min." | ( Influence of ketamine on non-pregnant uterus in vivo. Idvall, J; Sandahl, B; Stenberg, P; Ulmsten, U, 1982) | 1.54 |
| " Particular attention was focused on the establishment of an LD50 and the development of a dose-response curve." | ( Evaluation of ketamine/xylazine anesthesia in the guinea pig: toxicological parameters. D'Alleinne, CP; Mann, DD, 1982) | 0.62 |
| " Ketamine was found to have little effect at the dosage used while halothane proved to be a rapid induction agent providing a safe, continued level of surgical anaesthesia." | ( Anesthetization of a Cape fur seal (Arctocephalus pusillus) for the treatment of a chronic eye infection and amputation of a metatarsal bone. Barrow, S; Downes, SJ; Thurman, GD, 1982) | 1.17 |
| " Control and experimental animals were given a central nervous system stimulant, pentylenetetrazol (Medtrazol) at a dosage level (100 mg/kg) causing convulsions in 90% of animals." | ( Ketamine suppression of chemically induced convulsions in the two-day-old white leghorn cockerel. Reder, BS; Trapp, LD; Troutman, KC, 1980) | 1.7 |
| " For a correct anaesthesia the right dosage is of 0,40 mg/ml." | ( [The use of continuous-infusion ketamine in pediatric anesthesia]. Lipari, A, 1980) | 0.54 |
| "Cumulative dose-response curves have been widely used in many areas of pharmacology." | ( Cumulative dose-response curves in behavioral pharmacology. Wenger, GR, 1980) | 0.26 |
| " Dose-response curves of NOS activity versus anesthetic concentration were constructed." | ( Selective anesthetic inhibition of brain nitric oxide synthase. Breslow, MJ; Martin, LD; Tobin, JR; Traystman, RJ, 1994) | 0.29 |
| " The control group and the test groups were comparable with regard to biological data, duration of operation, applied dosage of local anaesthetics and actual anxiety before operation." | ( [Analgesia-sedation for maxillo-facial surgery with midazolam-pentazocine and miazolam-ketamine. Clinical double-blind study of anxiety, analgesia, sedation and amnesia]. Daubländer, M; Dick, W; Lipp, M; Sebastian, M, 1995) | 0.51 |
| " Cerebral function monitoring, if possible, will allow correlation of depth of anaesthesia with drug dosage and can ensure appropriate anaesthetic depth and recovery." | ( Comparison of conventional anaesthesia, total intravenous ketamine and epidural block for abdominal hysterectomy. Oberoi, GS; Yaubihi, N, 1994) | 0.53 |
| " Ketamine-fentanyl-propofol combination at a dosage of 30-0." | ( Comparison of anesthesia induced by ketamine-fentanyl combination and maintained by propofol or etomidate in New Zealand white rabbits. Griffith, JW; Lang, CM; Luo, Y; Russell, GB, 1995) | 1.48 |
| "Quantal dose-response curves were determined in 180 female patients to whom the drugs were administered individually and in combination." | ( Additive interactions between propofol and ketamine when used for anesthesia induction in female patients. Gin, T; Hong, W; Hui, TW; Plummer, J; Short, TG; Suen, T, 1995) | 0.55 |
| " Inadequate doses or dosing regimens should be avoided." | ( Pharmacology of intravenous sedatives and opioids in critically ill patients. Levine, RL, 1994) | 0.29 |
| " Ketamine (1, 5, 10 and 20 mg/kg) showed relatively weak antinociceptive effects with no apparent dose-response relationship." | ( Antinociceptive effects of ketamine-opioid combinations in the mouse tail flick test. Dambisya, YM; Lee, TL, 1994) | 1.5 |
| " Ketamine, an NMDA-receptor antagonist prevented completely the QUIN-induced hippocampal damage at a dosage of 40 mg/kg (140 mumol/kg, intraperitoneally applied)." | ( Ketamine, but not glycine modulates quinolinate-induced neurodegeneration. Henschke, G; Keilhoff, G; Wolf, G, ) | 2.48 |
| " Reversal with yohimbine hydrochloride using a mean dosage of 83 mg/animal resulted in a mean (SD) recovery time of 22." | ( Postpartum immobilization of adult female moose using xylazine, ketamine and yohimbine hydrochlorides. Addison, EM; Garner, DL, 1994) | 0.53 |
| " Dose-response estimation in 2 patients with PNS-related neuropathic pain revealed that ketamine was effective in dose-related fashion." | ( Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. Arndt, G; Backonja, M; Check, B; Gombar, KA; Zimmermann, M, 1994) | 0.76 |
| " Ketamine, in the dosage range studied (5-500 microM), inhibited the increase in [Ca2+]i stimulated by potassium-depolarization in a dose-dependent manner." | ( Ketamine inhibition of cytoplasmic calcium signalling in rat pheochromocytoma (PC-12) cells. Martin, CD; Wong, BS, 1993) | 2.64 |
| "Quantal dose-response curves were determined in 170 female patients for the drugs, individually and in combination." | ( Hypnotic and anesthetic interactions between ketamine and midazolam in female patients. Hong, W; Hui, TW; Short, TG, 1993) | 0.55 |
| " Two dosage levels were administered intraperitoneally." | ( Evaluation of ketamine-xylazine in Syrian hamsters. Clark, JA; Dixon, D; Forsythe, DB; Myers, PH; Payton, AJ; Snipe, JR, 1993) | 0.65 |
| " A slow and progressive increase of ketamine and morphine dosage (400 mg and 200 mg by the subcutaneous route, respectively) continued to provide adequate pain relief after 13 months of therapy despite signs of progressive disease." | ( Long-term ketamine subcutaneous continuous infusion in neuropathic cancer pain. Calligara, M; Lodi, F; Mercadante, S; Sapio, M; Serretta, R, 1995) | 0.97 |
| " Eleven muskrats were intramuscularly injected using a high (n = 7) or low (n = 4) dosage of a 20:1 mixture of ketamine (12 or 20 mg) and xylazine (0." | ( Immobilization of muskrats (Ondatra zibethicus) with ketamine and xylazine. Belant, JL, 1996) | 0.76 |
| " Optimal length was determined, a dose-response curve to acetylcholine was established, and the 50% effective dose (ED50) of acetylcholine was calculated." | ( Direct relaxant effects of intravenous anesthetics on airway smooth muscle. Bosnjak, ZJ; Cheng, EY; Coon, RL; Kampine, JP; Mazzeo, AJ, 1996) | 0.29 |
| "Using an isolated, electrically stimulated rat left afrium model, the dose-response curves to the muscarinic agonist carbachol and the anesthetics ketamine and thiopental were compared under conditions of high (10(-6)M isoproterenol bath concentration) or low (10(-6)M propranolol) beta-adrenergic tone." | ( In vitro myocardial depression by ketamine or thiopental is dependent on the underlying beta-adrenergic tone. Mathew, BP; Thurston, TA, 1996) | 0.77 |
| " There were wide variations in the blood propofol concentrations reached in individual sheep by using this standard dosing regimen." | ( Pharmacokinetics of propofol infusions, either alone or with ketamine, in sheep premedicated with acepromazine and papaveretum. Correia, D; Nolan, AM; Reid, J, 1996) | 0.54 |
| "To describe the serum concentrations of ketamine following a clinically relevant dosing schedule during cardiopulmonary bypass (CPB)." | ( Ketamine concentrations during cardiopulmonary bypass. Baker, AJ; Harrington, EM; Mazer, CD; McLean, RF; Walker, SE; Wong, BI, 1996) | 2 |
| "To describe the serum concentrations of ketamine following a clinically relevant dosing schedule during cardiopulmonary bypass (CPB)." | ( Ketamine concentrations during cardiopulmonary bypass. Baker, AJ; Harrington, EM; Mazer, CD; McLean, RF; Walker, SE; Wong, BI, 1996) | 2 |
| "This dosage regimen maintained general anaesthetic concentrations of ketamine throughout the operative period." | ( Ketamine concentrations during cardiopulmonary bypass. Baker, AJ; Harrington, EM; Mazer, CD; McLean, RF; Walker, SE; Wong, BI, 1996) | 1.97 |
| "IVPCA ketamine in combination with morphine provides superior postsurgical pain relief at lower dosage and with fewer side effects than morphine alone." | ( Comparison of morphine and morphine with ketamine for postoperative analgesia. Colclough, GW; Javery, KB; Steger, HG; Ussery, TW, 1996) | 1.04 |
| " The addition of methoxyflurane significantly potentiated the anaesthetic and analgesic properties of the high dosage ketamine-xylazine combination." | ( Evaluation of anaesthetic regimens in guineapigs. Crenshaw, D; Hinson, A; Radde, GR; Toth, LA, 1996) | 0.5 |
| " In the third, a parallel dose-response relationship, similar to that known for chronic tolerance, was observed for rapid tolerance." | ( Characterization of the Phenomenon of rapid tolerance to ethanol. Chau, A; Khanna, JM; Shah, G, ) | 0.13 |
| " This was done to evaluate the dose-response effect of these drugs when used for postoperative pain relief, and the results were applied to phase II of the study, in which all patients received ketamine pretreatment (total 30 mg) with each dose of lidocaine administered before and during surgery." | ( Ketamine potentiates analgesic effect of morphine in postoperative epidural pain control. Ho, ST; Liaw, WJ; Su, YF; Tung, CS; Wong, CS, ) | 1.76 |
| " The resulting lowered dosage of epidural morphine needed for postoperative pain relief reduces, in turn, the incidence of side effects." | ( Ketamine potentiates analgesic effect of morphine in postoperative epidural pain control. Ho, ST; Liaw, WJ; Su, YF; Tung, CS; Wong, CS, ) | 1.57 |
| " To improve anesthesia control, microprocessor infusion pumps Ohmeda and Becton-Dickinson, allowing for prompt dosage correction, consistent with individual needs, are employed." | ( [Total intravenous anesthesia (TIVA) with propofol/ketamine as an alternative for patients at risk in abdominal surgery]. Bochev, D; Gerzilova, L; Petrov, P; Vankov, I, 1996) | 0.55 |
| "Tolerance was produced in mice given morphine subcutaneously and was assessed by a cumulative dose-response analysis using the tail-flick test." | ( Ketamine attenuates and reverses morphine tolerance in rodents. Elliott, KJ; Inturrisi, CE; Shimoyama, M; Shimoyama, N, 1996) | 1.74 |
| "Prospective dose-response study." | ( Hemodynamic effects of carcinine in the anesthetized, instrumented, open-chest rat. Notterman, DA; Steinberg, C, 1996) | 0.29 |
| " The result strongly suggests a synergy from this combination that warrants a formal study of the dose-response relationship involved in this treatment and the mechanism by which this effect is achieved." | ( Epidural coadministration of ketamine, morphine and bupivacaine attenuates post-herpetic neuralgia--a case report. Cherng, CH; Ho, ST; Liaw, WJ; Shen, TT; Wong, CS, 1996) | 0.59 |
| " A thorough dose-response study using microdialysis in conscious rats indicated that low doses of ketamine (10, 20, and 30 mg/kg) increase glutamate outflow in the PFC, suggesting that at these doses ketamine may increase glutamatergic neurotransmission in the PFC at non-NMDA glutamate receptors." | ( Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. Adams, B; Daly, D; Moghaddam, B; Verma, A, 1997) | 0.77 |
| " Dosage based on mg/m2 body surface area or mg/kg body weight provided similar blood levels of ketamine." | ( A new route, jet injection for anesthetic induction in children--III. Ketamine pharmacokinetic studies. Domino, EF; Fekete, G; Kovacs, V; Stetson, P; Zsigmond, EK, 1997) | 0.75 |
| " Thus, a 50% reduction of dosage is possible to achieve comparable clinical results." | ( [From the racemate to the eutomer: (S)-ketamine. Renaissance of a substance?]. Adams, HA; Werner, C, 1997) | 0.57 |
| " Skunks were immobilized with a mean (+/- SD) dosage of 15." | ( Field immobilization of pygmy spotted skunks from Mexico. Cantú Salazar, L; Casariego Madorell, MA; De Villa Meza, A; González-Romero, A; Hidalgo Mihart, MG; Laundré, JW; López González, CA; Martínez Meyer, E, 1998) | 0.3 |
| " The results demonstrate that the behavioral hyperalgesia associated with carrageenan-induced hindpaw inflammation in rats is attenuated by the intrathecal administration of racemic and S(+)-ketamine, but not R(-)-ketamine, which only displayed an insignificant trend toward a dose-response relationship." | ( Antinociceptive effect of the S(+)-enantiomer of ketamine on carrageenan hyperalgesia after intrathecal administration in rats. Benedek, G; Dobos, I; Horváth, G; Klimscha, W; Szikszay, M, 1998) | 0.74 |
| " Propofol but not ketamine, however, caused a leftward shift in the dose-response curve to extracellular Ca2+ for shortening, with no concomitant effect on peak [Ca2+]i." | ( Propofol and ketamine only inhibit intracellular Ca2+ transients and contraction in rat ventricular myocytes at supraclinical concentrations. Damron, DS; Kanaya, N; Murray, PA, 1998) | 1 |
| " An increased dosage of physostigmine has yet to be studied, but is likely to cause a higher rate of side effects such as nausea, vomiting, bradycardia and possibly even tonic-clonic seizures." | ( [Recovery time after (S)-ketamine or ketamine racemate. Recovery time after short anesthesia in volunteers]. Engelhardt, W; Hartung, E; Marouche, A; Stahl, K, 1998) | 0.6 |
| " Medetomidine was administered intramuscularly at a dose of 1000 micrograms/m2 body surface area 10 to 15 minutes before the induction of anaesthesia by the administration of propofol (n = 44) or ketamine (n = 40) dosed to effect." | ( Clinical efficacy and safety of propofol or ketamine anaesthesia in dogs premedicated with medetomidine. Hellebrekers, LJ; Hird, JF; Rosenhagen, CU; Sap, R; Vainio, O; van Herpen, H, 1998) | 0.75 |
| " The authors wished to quantify the dose-response of ketamine with respect to sedation adequacy, time to discharge, and adverse effects in order to identify an optimal dose." | ( What is the optimal dose of intramuscular ketamine for pediatric sedation? Garrett, W; Green, SM; Hopkins, GA; Hummel, CB; Rothrock, SG; Wittlake, WA, 1999) | 0.82 |
| " produced adequate sedation in 93%-100% of children, suggesting that this dosing range may be optimal for ED procedural sedation." | ( What is the optimal dose of intramuscular ketamine for pediatric sedation? Garrett, W; Green, SM; Hopkins, GA; Hummel, CB; Rothrock, SG; Wittlake, WA, 1999) | 0.57 |
| " These effects had short time courses and steep dose-response curves." | ( Behavioral effects of ketamine, an NMDA glutamatergic antagonist, in non-human primates. Casey, DE; Shiigi, Y, 1999) | 0.62 |
| " In 5 children, the dosing error was not discovered until late in the sedation, often when the child was not waking at the expected time." | ( Inadvertent ketamine overdose in children: clinical manifestations and outcome. Carlson, D; Clark, R; Cohen, M; Green, SM; Hostetler, MA; Rothrock, SG, 1999) | 0.68 |
| " In addition, we obtained dose-response curves for possible local anesthetic effects." | ( The effects of intradermal fentanyl and ketamine on capsaicin-induced secondary hyperalgesia and flare reaction. Blunk, JA; Koppert, W; Likar, R; Schmelz, M; Sittl, R; Zeck, S, 1999) | 0.57 |
| " However, there was an increase in postoperative nausea and vomiting, psychomimetic side effects, and delay in discharge times with the largest ketamine dosage (Group 4)." | ( The use of a ketamine-propofol combination during monitored anesthesia care. Avramov, MN; Badrinath, S; Ivankovich, AD; Shadrick, M; Witt, TR, 2000) | 0.88 |
| " The dose that yielded 50% of the maximum possible effect (ED50) and dose-response and time-course curves were determined for the ketamines (30-300 microg), morphine (0." | ( The effects of ketamine and its enantiomers on the morphine- or dexmedetomidine-induced antinociception after intrathecal administration in rats. Benedek, G; Dobos, I; Horvath, G; Joó, G; Kekesi, G; Klimscha, W; Szikszay, M, 2000) | 0.86 |
| " Ketamine and N(2)O were administered alone or in combination by various dosing regimens to adult female rats for a duration of 3 h and the severity of cerebrocortical neurotoxic changes was quantified histologically." | ( Ketamine potentiates cerebrocortical damage induced by the common anaesthetic agent nitrous oxide in adult rats. Benshoff, N; Jevtovic-Todorovic, V; Olney, JW, 2000) | 2.66 |
| "Results of previous studies of rectal ketamine as a pediatric premedication are clouded because of lack of dose-response relation, inappropriate time of assessing sedative effects, and previous administration or coadministration of benzodiazepines." | ( Reevaluation of rectal ketamine premedication in children: comparison with rectal midazolam. Nishikawa, T; Saito, A; Sato, M; Tanaka, M, 2000) | 0.89 |
| " Increasing doses of ketamine were administered 60 min after stimulation to generate a dose-response curve." | ( Ketamine controls prolonged status epilepticus. Bertram, EH; Borris, DJ; Kapur, J, 2000) | 2.07 |
| " Dose-response studies of S(+)-ketamine for rectal premedication in pediatric anesthesia may be warranted." | ( S(+)-ketamine for rectal premedication in children. Erlacher, W; Freitag, H; Greher, M; Höchtl, A; Marhofer, P; Semsroth, M, 2001) | 1.11 |
| " Pretreatment with phencyclidine [PCP] at a dose of 3 mg/kg shifted the DOM dose-response relationship to the left." | ( Potentiation of DOM-induced stimulus control by non-competitive NMDA antagonists: a link between the glutamatergic and serotonergic hypotheses of schizophrenia. Doat, M; Rabin, RA; Winter, JC, 2000) | 0.31 |
| "To develop a dosage correlated with shoulder height (SH) in centimeters for effective immobilization of free-ranging giraffes, using a combination of medetomidine (MED) and ketamine (KET) and reversal with atipamezole (ATP)." | ( Use of medetomidine and ketamine for immobilization of free-ranging giraffes. Bush, M; Grobler, DG; Lance, WR; Phillips, LG; Raath, JP; Stamper, MA, 2001) | 0.81 |
| " The iteration and the prediction procedures may be used to reduce the number of experimental animals in dose-response studies in other species." | ( Determination of optimal immobilizing doses of a medetomidine hydrochloride and ketamine hydrochloride combination in captive reindeer. Arnemo, JM; Larsen, S; Ryeng, KA, 2001) | 0.54 |
| "001) but times from dosing to discharge (medians 105 and 110 minutes) were similar." | ( Sedation for children requiring wound repair: a randomised controlled double blind comparison of oral midazolam and oral ketamine. Kendall, JM; Younge, PA, 2001) | 0.52 |
| " Thirty healthy adult turtles were assigned randomly to one of two dosage groups." | ( Medetomidine-ketamine anesthesia in red-eared slider turtles (Trachemys scripta elegans). Diggs, HE; Greer, LL; Jenne, KJ, 2001) | 0.68 |
| " Success rates were 28% for the 8 mg/kg dosage and 44% for the 10 mg/kg dosage." | ( A comparison of two oral ketamine-diazepam regimens for the sedation of anxious pediatric dental patients. Sullivan, DC; Webb, MD; Wilson, CF, ) | 0.43 |
| " The magnitude of ketamine-induced changes in positive symptoms was similar, although the psychosis baseline differed, and the dose-response profiles over time were superimposable across the two populations." | ( Effects of ketamine in normal and schizophrenic volunteers. Lahti, AC; Parwani, A; Tamara Michaelidis, BA; Tamminga, CA; Weiler, MA, 2001) | 1.03 |
| " Dose-response curves were determined for endomorphin-1 (0." | ( The synergistic antinociceptive interactions of endomorphin-1 with dexmedetomidine and/or S(+)-ketamine in rats. Benedek, G; Dobos, I; Horvath, G; Joo, G; Klimscha, W; Toth, G, 2001) | 0.53 |
| " In contrast, BCl causes a parallel shift in the ACh dose-response curve at the alpha7 nAChR suggesting competitive inhibition." | ( Ketamine and its preservative, benzethonium chloride, both inhibit human recombinant alpha7 and alpha4beta2 neuronal nicotinic acetylcholine receptors in Xenopus oocytes. Coates, KM; Flood, P, 2001) | 1.75 |
| " We assessed the involvement of the mu-opioid receptor in S(+) ketamine-induced respiratory depression and antinociception by performing dose-response curves in exon 2 mu-opioid receptor knockout mice (MOR(-/-)) and their wild-type littermates (WT)." | ( The involvement of the mu-opioid receptor in ketamine-induced respiratory depression and antinociception. Dahan, A; Kieffer, BL; Matthes, HW; Nieuwenhuijs, D; Olievier, C; Sarton, E; Teppema, LJ, 2001) | 0.81 |
| " The ED50 for hypnosis and the LD50 were determined for each drug separately, and a dose-response curve was prepared for each drug, using combinations of propofol-lidocane and ketamine-lidocaine at three different dose ratios." | ( Changes in effective and lethal doses of intravenous anesthetics and lidocaine when used in combination in mice. Barak, M; Ben-Shlomo, I; Katz, Y, 2001) | 0.5 |
| " This study concludes that the addition of ketamine to morphine, in this dosage regimen, administered via PCAS for postoperative pain control, does not confer benefit following total abdominal hysterectomy." | ( Effect of the addition of ketamine to morphine in patient-controlled analgesia. Crooks, BA; Miller, CD; Murdoch, CJ, 2002) | 0.88 |
| "Of the 5,766 cats for which dosing records were complete, 4,584 (79." | ( Use of the anesthetic combination of tiletamine, zolazepam, ketamine, and xylazine for neutering feral cats. Centonze, LA; Cistola, AM; Levy, JK; Robertson, SA; Williams, LS, 2002) | 0.56 |
| " Anesthesia was rapidly and completely reversed by intravenous injections of naltrexone at 30 times the THAI dosage (0." | ( Anesthesia of boma-captured Lichtenstein's hartebeest (Sigmoceros lichtensteinii) with a combination of thiafentanil, medetomidine, and ketamine. Bush, M; Citino, SB; Grobler, D; Lance, W, 2002) | 0.52 |
| " Blood pressure and heart rate were also monitored before dosing and after the dosing regimen." | ( Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers. Fisher, G; Growcott, JW; Hughes, AM; Rhodes, J; Sellers, M, 2002) | 0.57 |
| " Dose-response curves for the antinociceptive effects of ketamine alone and ketamine in conjunction with the mu opioid fentanyl were constructed." | ( Potentiation by ketamine of fentanyl antinociception. I. An experimental study in rats showing that ketamine administered by non-spinal routes targets spinal cord antinociceptive systems. Bajunaki, E; Goodchild, CS; Nadeson, R; Tucker, A, 2002) | 0.91 |
| " Dose-response determinations for dizocilpine [IG and intramuscular (IM)], PCP (IM) and ketamine (IM) were made under two training intervals (30 and 60 min)." | ( Characterization of the discriminative stimulus effects of N-methyl- D-aspartate ligands under different ethanol training conditions in the cynomolgus monkey ( Macaca fascicularis). Grant, KA; Jordan, K; Szeliga, KT; Vivian, JA; Waters, CA, 2002) | 0.54 |
| " We report here that many parameters, such as anaesthesia, position of animal during and post delivery, and dosing schedule, must be optimized in concert with each other and that results from one species cannot be extrapolated directly to another animal model." | ( Tracking the tissue distribution of marker dye following intranasal delivery in mice and chinchillas: a multifactorial analysis of parameters affecting nasal retention. Bakaletz, LO; Hjemdahl-Monsen, EJ; Novotny, LA; Thanavala, Y; Visweswaraiah, A, 2002) | 0.31 |
| " Using a mouse hot-plate test, dose-response relationships were first determined for all compounds individually and then for opioids co-administered with fixed doses of ketamine or dextromethorphan." | ( Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain. Baker, AK; Hoffmann, VL; Meert, TF, 2002) | 0.83 |
| "Systemic or regional administration of the non-competitive NMDA antagonist dizocilpine into the VTA significantly increased the rate of heroin SA and shifted the heroin dose-response curve to the right." | ( Blockade of ionotropic glutamatergic transmission in the ventral tegmental area reduces heroin reinforcement in rat. Stein, EA; Xi, ZX, 2002) | 0.31 |
| " Using a mouse hot-plate test, dose-response relationships were first determined for all compounds individually and then for opioids co-administered with fixed doses of clonidine, ketamine or dextromethorphan." | ( Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay. Baker, AK; Hoffmann, VL; Meert, TF, 2002) | 0.51 |
| " We propose that the type of ketamine preparation should be selected in accordance with the patient's disease condition and the required dosage amount of ketamine." | ( Plasma concentration profiles of ketamine and norketamine after administration of various ketamine preparations to healthy Japanese volunteers. Aoyama, T; Ashizawa, N; Hiraishi, T; Iga, T; Kariya, S; Ohtani, M; Uchino, K; Yamada, Y; Yamamura, Y; Yanagihara, Y, 2003) | 0.89 |
| " Between October 1998-July 1999, we conducted four trials, evaluating three different dosage ratios of ketamine and xylazine (2." | ( Immobilization of swift foxes with ketamine hydrochloride-xylazine hydrochloride. Sovada, MA; Telesco, RL, 2002) | 0.81 |
| " The dosage required to achieve a satisfactory level of anesthesia was smaller for subantarctic fur seals than for most other species of seals and was less for animals in better body condition." | ( Response of wild subantarctic fur seal (Arctocephalus tropicalis) females to ketamine and tiletamine-zolazepam anesthesia. Beauplet, G; Dabin, W; Guinet, C, 2002) | 0.54 |
| " The mean dosage (0." | ( Tiletamine-zolazepam, ketamine, and xylazine anesthesia of captive cheetah (Acinonyx jubatus). Bonar, CJ; Evans, SE; Lewandowski, AH, 2002) | 0.63 |
| " FFTs of raw signals were generated at baseline (predose) and after intraperitoneal dosing of the rats with atropine (30 min postdose; 6 mg/kg), caffeine (90 and 150 min postdose; 30 mg/kg), ketamine (15 and 30 min postdose; 50 mg/kg), and pentobarbarbital (60 and 90 min postdose; 40 mg/kg)." | ( Development of a quantitative method for evaluation of the electroencephalogram of rats by using radiotelemetry. Cain, C; Fitzgerald, AL; Juneau, P; Southwick, K, 2003) | 0.51 |
| " Each animal received a 8-13 mL/kg body weight dosage of barium liquid (30% weight:volume)." | ( The normal upper gastrointestinal examination in the ferret. Fox, JG; Manning, A; Marini, RP; Schwarz, LA; Solano, M, ) | 0.13 |
| " However, critical hemoglobin was significantly higher in the animals receiving the higher anesthetic dosage (1." | ( Tolerance to acute isovolemic hemodilution. Effect of anesthetic depth. De Hert, S; Degroote, F; Mathieu, N; Schmartz, D; Van der Linden, P; Vincent, JL; Zhang, H, 2003) | 0.32 |
| " An initial dose-response trial determined the efficacy of either propofol (3." | ( Evaluation of propofol and medetomidine-ketamine for short-term immobilization of Gulf of Mexico sturgeon (Acipenser oxyrinchus de soti). Fleming, GJ; Francis Floyd, R; Heard, DJ; Riggs, A, 2003) | 0.59 |
| "5 mg kg(-1) at 15 min after induction of anaesthesia directly followed by a maintenance dosage of 50 microg kg(-1) min(-1), while the control group received saline (i." | ( Effects of intravenous lidocaine on isoflurane concentration, physiological parameters, metabolic parameters and stress-related hormones in horses undergoing surgery. Dzikiti, TB; Hellebrekers, LJ; van Dijk, P, 2003) | 0.32 |
| " The differences between the racemic ketamine/midazolam and the S(+)-ketamine/midazolam groups were investigated regarding the total dosage of sedative drugs, side effects, and the awakening period." | ( Comparison of analgesic/sedative effect of racemic ketamine and S(+)-ketamine during cardiac catheterization in newborns and children. Berger, F; Ewert, P; Haas, NA; Lange, PE; Pees, C, ) | 0.66 |
| "We propose that sensitivities to ethanol- and ketamine-induced locomotion are genetically correlated and that the combined effects of ethanol and ketamine in FAST mice reflect a leftward shift in ethanol's biphasic dose-response curve." | ( Sensitivity to ketamine, alone or in combination with ethanol, is altered in mice selectively bred for sensitivity to ethanol's locomotor effects. Meyer, PJ; Phillips, TJ, 2003) | 0.93 |
| " Most reports demonstrate no or mild psychotomimetic effects when ketamine is dosed at sub-anesthetic doses." | ( Ketamine as an analgesic: parenteral, oral, rectal, subcutaneous, transdermal and intranasal administration. Kronenberg, RH, 2002) | 1.99 |
| " The rationale for this treatment, along with dosing guidelines and possible drawbacks, is discussed." | ( Ketamine patient-controlled analgesia for dysesthetic central pain. Cohen, SP; DeJesus, M, 2004) | 1.77 |
| " However the least dosage of ketamine to inhibit IL-6 was 5 mg/kg in our experiment." | ( Ketamine suppresses intestinal NF-kappa B activation and proinflammatory cytokine in endotoxic rats. Liu, H; Sun, J; Wang, XD; Xu, JG, 2004) | 2.06 |
| " No significant difference in blood concentration was observed at different dosing times (10:00 and 22:00)." | ( Chronopharmacological studies of ketamine in normal and NMDA epsilon1 receptor knockout mice. Hakamata, Y; Kobahashi, M; Kobayashi, E; Mishina, M; Murayama, T; Sato, Y; Seo, N; Wainai, T, 2004) | 0.6 |
| " They did not, however, show discriminative behavior according to the type and dosage of the drugs." | ( Visual discrimination of normal and drug induced behavior in quails (Coturnix coturnix japonica). Shinohara, N; Watanabe, S; Yamazaki, Y, 2004) | 0.32 |
| "0001) with pain relief within 10 min of dosing and lasting for up to 60 min." | ( Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study. Albin, R; Brennen, L; Brookoff, D; Carr, DB; Denman, WT; Firestone, L; Goudas, LC; Green, G; Hamilton, D; Lavin, PT; Mermelstein, F; Rogers, MC; Staats, PS, 2004) | 0.6 |
| "Compared to other laboratory animals, little is known about the use of anesthetics in birds, potentially resulting in the use of improper dosing regimens." | ( Lack of efficacy of injectable ketamine with xylazine or diazepam for anesthesia in chickens. Broderson, JR; Clifton, KR; Poulos, S; Varner, J; Wyatt, RD, 2004) | 0.61 |
| " The authors prospectively assessed inter- and intra-individual variability in ketamine dosage for sedation in repetitive invasive procedures in children with malignancies." | ( Inter- and intraindividual variability in ketamine dosage in repetitive invasive procedures in children with malignancies. Aliani, S; Gottschling, S; Graf, N; Meyer, S, 2004) | 0.82 |
| "This study was performed to determine the optimal reversal dosage of atipamezole on medetomidine-ketamine combination anesthesia." | ( Reversal of medetomidine-ketamine combination anesthesia in rabbits by atipamezole. Jeong, SM; Kim, MS; Nam, TC; Park, JH; Seo, KM, 2004) | 0.84 |
| "The purpose of the case study was to investigate the effect from the bolus dosing of midazolam and ketamine on the autonomic hemostasis in patients with ischemic heart disease (IHD) with the prevalence of the activity of sympathetic or parasympathetic parts in the autonomic nervous system." | ( [Effect of intravenous hypnotics on autonomic response in patients with ischemic heart disease]. Aksel'rod, BA; Babalian, GV; Shmyrin, MM, ) | 0.35 |
| " We assessed the suitable dosage of narcotics and its correlation to severe respiratory adverse events in 269 cases of ketamine/xylazine anesthesia in male Wistar rats for performance of magnetic resonance imaging after middle cerebral artery occlusion (MCAO) or sham surgery." | ( Ketamine/xylazine anesthesia for radiologic imaging of neurologically impaired rats: dose response, respiratory depression, and management of complications. Dittmar, MS; Fehm, NP; Horn, M; Vatankhah, B, 2004) | 1.97 |
| " In the present study, we prepared oral gel dosage forms of ketamine using agar." | ( [Preparing oral dosage form of ketamine in the hospital for simplicity and patient compliance--preparations using agar]. Iseki, K; Kaneuchi, M; Kohri, N; Sakai, H; Senbongi, K, 2005) | 0.86 |
| " Patients above 61 years had smaller dosage of pentazocine compared with those in patients under 61 years." | ( [Anesthetic management by total intravenous anesthesia with propofol, pentazocine and ketamine]. Abe, F; Imamura, M; Masamune, T; Nonaka, A; Suzuki, S, 2005) | 0.55 |
| " Younger children required a higher dosage (p=0." | ( Use of midazolam and ketamine as sedation for children undergoing minor operative procedures. Chan, GC; Cheuk, DK; Ha, SY; Lau, YL; Lee, TL; Ma, E; Wong, WH, 2005) | 0.65 |
| " The optimum dosage for nyala was a combination of A3080 (40-50 microg/kg), MED (60-80 microg/kg) plus 200 mg of KET/animal." | ( Anaesthesia of nyala (Tragelaphus angasi) with a combination of thiafentanil (A3080), medetomidine and ketamine. Bush, M; Cooper, DV; Grobler, D; Jessup, D; Lance, W, 2005) | 0.54 |
| "Anesthesia has an influence on the disposition of lidocaine in horses, and a change in dosing during anesthesia should be considered." | ( Influence of general anesthesia on pharmacokinetics of intravenous lidocaine infusion in horses. Feary, DJ; Mama, KR; Thomasy, S; Wagner, AE, 2005) | 0.33 |
| " At present, the best options for medication treatment are tricyclic antidepressants in lower dosage than usual in psychiatric disorders and a wide range of anticonvulsants." | ( Current trends in neuropathic pain treatments with special reference to fibromyalgia. Ackenheil, M; Offenbaecher, M, 2005) | 0.33 |
| " A combination of 500 mg zolazepam, 500 mg tiletamine, 500 mg xylazine, and 1000 mg (10 ml) ketamine, administered in a dosage of 1 ml per 100-150 kg bodyweight (depending on the species), proved to be most reliable and effective." | ( [Immobilization of cattle and bison with a combination of xylazine, zolazepam-tiletamine and ketamine]. Hofkes, LM; Hoyer, MJ; Overgaauw, PA; van Dijk, P, 2005) | 0.77 |
| " Sedation levels of patients were maintained between scores 3 and 4 according to Ramsey sedation scores; when necessary, half of the starting drug dosage was administered for the maintenance of sedation." | ( Comparison of propofol with propofol-ketamine combination in pediatric patients undergoing auditory brainstem response testing. Akin, A; Aydogan, H; Boyaci, A; Esmaoglu, A; Gulcu, N; Tosun, Z, 2005) | 0.6 |
| "Additional dosage was needed for 21 cases in group P and eight cases in group PK (p=0." | ( Comparison of propofol with propofol-ketamine combination in pediatric patients undergoing auditory brainstem response testing. Akin, A; Aydogan, H; Boyaci, A; Esmaoglu, A; Gulcu, N; Tosun, Z, 2005) | 0.6 |
| " However, various dosing regimens when used alone or in combination have variable efficacy and side effect profile." | ( Comparative evaluation of midazolam and ketamine with midazolam alone as oral premedication. Chari, P; Ghai, B; Grandhe, RP; Kumar, A, 2005) | 0.6 |
| " Reproducible shifts in the dose-response of skeletal muscle to caffeine and halothane are the basis of the current in vitro diagnostic caffeine-halothane contracture test." | ( Effects of caffeine, halothane, and 4-chloro-m-cresol on skeletal muscle lactate and pyruvate in malignant hyperthermia-susceptible and normal swine as assessed by microdialysis. Bina, S; Bünger, R; Cowan, G; Karaian, J; Mongan, P; Muldoon, S, 2006) | 0.33 |
| " Our findings suggest that a single preoperative dose of ketamine provided less analgesia compared with other dosing regimens that included intraoperative infusions or postoperative administration." | ( The influence of timing of systemic ketamine administration on postoperative morphine consumption. Alev, T; Bilgin, H; Bilgin, T; Kerimoğlu, B; Osma, S; Ozcan, B; Toker, A; Uçkunkaya, N, 2005) | 0.85 |
| "The present dose-response study sought to determine the effects of subanesthetic dosages (4-16 mg/kg) of ketamine on locomotion, sensorimotor gating (PPI), working memory, as well as c-fos expression in various limbic regions implicated in the pathogenesis of schizophrenia." | ( Dose-response characteristics of ketamine effect on locomotion, cognitive function and central neuronal activity. Den Boer, JA; Fokkema, DS; Imre, G; Ter Horst, GJ, 2006) | 0.83 |
| " There was a direct correlation between the concentration of K in cavy hair and the dose and DHNK was detected only in high dosage group." | ( Hair analysis for ketamine and its metabolites. Shen, M; Xiang, P; Zhuo, X, 2006) | 0.67 |
| " Pain unpleasantness declined as ketamine dosage was increased (55." | ( Imaging pain modulation by subanesthetic S-(+)-ketamine. Freynhagen, R; Kochs, EF; Sprenger, T; Tölle, TR; Valet, M; Wagner, KJ; Woltmann, R; Zimmer, C, 2006) | 0.87 |
| " Twenty-four hours after ischemia, five rats in each group were killed by injecting the above dosage of ketamine or ketamine-midazolam intraperitoneally and infarct size was measured." | ( Effects of ketamine-midazolam anesthesia on the expression of NMDA and AMPA receptor subunit in the peri-infarction of rat brain. Liu, Y; Qiu, SD; Tian, YF; Wang, Y; Zhang, PB; Zhang, YL, 2006) | 0.94 |
| "The authors conclude that repeated intrathecal administration of preservative-free S(+)-ketamine in a clinically relevant concentration and dosage has, considering the extent and severity of the lesions, a toxic effect on the central nervous system of rabbits." | ( Severe toxic damage to the rabbit spinal cord after intrathecal administration of preservative-free S(+)-ketamine. de Haan, P; Dijkgraaf, MG; Hollmann, MW; Pennings, FA; Troost, D; van der Vegt, MH; Vranken, JH, 2006) | 0.77 |
| " A noninvasive dosing line was placed in the duodenum by use of endoscopy, and 50% dextrose (3 ml/kg) was administered." | ( Comparison of three anesthetic protocols for intraduodenal drug administration using endoscopy in rhesus monkeys (Macaca mulatta). Authier, S; Breault, C; Chaurand, F; Legaspi, M; Troncy, E, 2006) | 0.33 |
| "The total analgesic dosage and PCA dosage in the two groups were similar (P>0." | ( [Low-dose ketamine combined with fentanyl for intravenous postoperative analgesia in elderly patients]. Chen, YM; Liang, SW; Lin, CS, 2006) | 0.74 |
| "Using a crossover design, the effects of the addition of ketamine to a previously determined optimal hand-injected immobilization dosage of carfentanil/xylazine were evaluated in 11 adult white-tailed deer (Odocoileus virginianus)." | ( Effects of ketamine on carfentanil and xylazine immobilization of white-tailed deer (Odocoileus virginianus). Miller, KV; Osborn, DA; Ramsay, EC; Schumacher, J; Storms, TN, 2006) | 0.97 |
| " To explore the optimal KX dosage and observation time for murine echocardiography, we compared the effects of various KX combinations on echocardiographic measurement." | ( Optimizing dosage of ketamine and xylazine in murine echocardiography. Dart, AM; Du, XJ; Ming, Z; Xu, Q, ) | 0.45 |
| "Three series of trials involving 10 domestic short-haired cats were carried out to determine the influence of dosage of contrast media or type of chemical restraint on feline excretory urography." | ( Influence of dosage and chemical restraints on feline excretory urography. Adetunji, A; Ajadi, RA; Okoh, JU; Omoerah, VO, 2006) | 0.33 |
| "Adjuvants are compounds which by themselves have undesirable side-effects or low potency but in combination with opioids allow a reduction of narcotic dosing for postoperative pain control." | ( Useful adjuvants for postoperative pain management. Buvanendran, A; Kroin, JS, 2007) | 0.34 |
| "(1) In the OVA-sensitized and challenged rats, the dose-response curve of the expiratory resistance (Re) shifted to the upper-left +/- ward compared with that of PBS control rats." | ( [Protective effects of ketamine on allergen-induced airway inflammatory injure and high airway reactivity in asthma: experiment with rats]. Ding, ZN; Fu, CZ; Qian, YN; Rong, HB; Xu, YM; Zhu, MM; Zhu, W, 2007) | 0.65 |
| " Adolescent and adult male rats were injected once daily with saline or with a dose of one of the test drugs for two 5-day dosing periods, separated by a 2-day drug holiday during which they remained in their home cages." | ( Age-dependent differences in sensitivity and sensitization to cannabinoids and 'club drugs' in male adolescent and adult rats. Evans, RL; Grainger, DB; Nicholson, KL; Wiley, JL, 2008) | 0.35 |
| " Dosage C in contrast had fewer side effects but less favourable cardiovascular results and a longer recovery period." | ( A comparative clinical study of three different dosages of intramuscular midazolam-medetomidine-ketamine immobilization in cats. Busch, R; Ebner, J; Erhardt, W; Henke, J; Wehr, U, 2007) | 0.56 |
| " To reach an adequate cerebral perfusion pressure (CPP), the norepinephrine dosage was adapted successively." | ( Effects of fentanyl and S(+)-ketamine on cerebral hemodynamics, gastrointestinal motility, and need of vasopressors in patients with intracranial pathologies: a pilot study. Bertsch, T; Horn, P; Muench, E; Quintel, M; Schmittner, MD; Vajkoczy, P; Vajkoczy, SL, 2007) | 0.63 |
| " The addition of flumazenil showed no significant difference to atipamezole alone, but subcutaneous administration of atipamezole alone was not sufficient in the dosage used to show an advantage compared to non-reversed cats." | ( Partial antagonization of midazolam-medetomidine-ketamine in cats--atipamezole versus combined atipamezole and flumazenil. Baumgartner, C; Ebner, J; Erhardt, W; Henke, J; Wehr, U, 2007) | 0.59 |
| " Nursing considerations include close monitoring of vital signs during the initial dosage and follow-up observations of the effectiveness of the medications." | ( The use of ketamine as adjuvant therapy to control severe pain. Campbell-Fleming, JM; Williams, A, 2008) | 0.74 |
| " Since ketamine's analgesic potency and duration of effect in neuropathic pain are directly dose-dependant, we investigated the efficacy of ketamine in anesthetic dosage in refractory CRPS patients that had failed available standard therapies." | ( Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study. Altemeyer, KH; Dieterich, HJ; Grothusen, J; Kiefer, RT; Koffler, S; Ploppa, A; Rohr, P; Schwartzman, RJ; Unertl, K, 2008) | 1.18 |
| "Twenty ASA I-III patients suffering from refractory CRPS received ketamine in anesthetic dosage over 5 days." | ( Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study. Altemeyer, KH; Dieterich, HJ; Grothusen, J; Kiefer, RT; Koffler, S; Ploppa, A; Rohr, P; Schwartzman, RJ; Unertl, K, 2008) | 0.96 |
| " The aim of this study was to clarify whether low-dose S(+)-ketamine used to prevent chronic pain similarly stimulates the cardiovascular system and to determine the impact of propofol dosage on this effect." | ( [Sympathomimetic effects of low-dose S(+)-ketamine. Effect of propofol dosage]. Linstedt, U; Maier, C; Timm, C; Weiss, T; Zenz, M, 2008) | 0.85 |
| " In the presence of a propofol dosage >3 mg/kg BW/h the stimulatory cardiovascular effect could no longer be observed." | ( [Sympathomimetic effects of low-dose S(+)-ketamine. Effect of propofol dosage]. Linstedt, U; Maier, C; Timm, C; Weiss, T; Zenz, M, 2008) | 0.61 |
| " This stimulatory effect is nullified in the presence of a continuous propofol infusion at a dosage of more than 3 mg/kg BW/h." | ( [Sympathomimetic effects of low-dose S(+)-ketamine. Effect of propofol dosage]. Linstedt, U; Maier, C; Timm, C; Weiss, T; Zenz, M, 2008) | 0.61 |
| " Addictive/dependent patterns of behaviour were also a concern: the majority of frequent users reported using the drug without stopping until supplies ran out and the mean increase in dosage in this group was six-fold from initiation to current use." | ( Journey through the K-hole: phenomenological aspects of ketamine use. Curran, HV; Kamboj, SK; Morgan, CJ; Muetzelfeldt, L; Rees, H; Taylor, J, 2008) | 0.59 |
| " Dose-response functions determined with both training compounds revealed a clear dissociation between the discriminative stimulus effects of these drugs." | ( Differentiating the discriminative stimulus effects of gamma-hydroxybutyrate and ethanol in a three-choice drug discrimination procedure in rats. Baker, LE; Poling, A; Pynnonen, DM; Searcy, GD, 2008) | 0.35 |
| " Morphine equivalent units were calculated using standard dosage conversion factors." | ( The correlation between ketamine and posttraumatic stress disorder in burned service members. Black, IH; Garza, TH; Gaylord, KM; Maani, CV; McGhee, LL, 2008) | 0.65 |
| "In a dose-response study, male adult Wistar rats were treated with 10, 20, 40 or 80 mg/kg ketamine intraperitoneally twice daily for 4 days." | ( Induction of hepatic glutathione S-transferase and UDP-glucuronosyltransferase activities by ketamine in rats. Chan, WH; Fan, SZ; Hsiao, PN; Hung, MH; Su, HC; Sun, WZ; Ueng, TH, 2008) | 0.79 |
| "The results of the dose-response study showed that treatment of rats with 10, 20, 40, or 80 mg/kg ketamine produced 19%, 20%, 18%, and 25% increases respectively in the catalytic activity of hepatic cytosolic GST, and 41%, 41%, 35%, and 38% increases respectively in the catalytic activity of microsomal UGT." | ( Induction of hepatic glutathione S-transferase and UDP-glucuronosyltransferase activities by ketamine in rats. Chan, WH; Fan, SZ; Hsiao, PN; Hung, MH; Su, HC; Sun, WZ; Ueng, TH, 2008) | 0.78 |
| " Ketamine, PCP, and MK-801 enhanced catalepsy along inverted U-shaped dose-response curves likely because higher doses affected motor coordination, which limited their catalepsy-enhancing effects." | ( Cataleptic effects of gamma-hydroxybutyrate (GHB) and baclofen in mice: mediation by GABA(B) receptors, but differential enhancement by N-methyl-d-aspartate (NMDA) receptor antagonists. France, CP; Koek, W, 2008) | 1.26 |
| " To further validate this model the mRNA levels of neurotrophic factors NGF, NT-3, and BDNF and their receptors TrkA, TrkB, and TrkC, respectively, were measured in different brain areas in Ket-pretreated rats subchronically dosed with the atypical antipsychotic drug risperidone (Ris)." | ( Expression of mRNA of neurotrophic factors and their receptors are significantly altered after subchronic ketamine treatment. Becker, A; Grecksch, G; Roskoden, T; Schwegler, H, 2008) | 0.56 |
| "Ketamine decreases postoperative morphine consumption, but its optimal dosing and duration of administration remain unclear." | ( Postoperative ketamine administration decreases morphine consumption in major abdominal surgery: a prospective, randomized, double-blind, controlled study. Beloucif, S; Dupont, H; Lorne, E; Montravers, P; Moubarak, M; Samarcq, D; Zakine, J, 2008) | 2.15 |
| " In addition, the effects of dosing route on haematological stress markers were evaluated." | ( The efficacy of orally dosed ketamine and ketamine/medetomidine compared with intramuscular ketamine in rhesus macaques (Macaca mulatta) and the effects of dosing route on haematological stress markers. Bates, WA; Feng, C; Winterborn, AN; Wyatt, JD, 2008) | 0.64 |
| " Animals were trained to accept oral dosing and then randomly assigned to one of three drug regimens: (1) ketamine IM, (2) ketamine PO, (3) Ketamine/medetomidine PO." | ( The efficacy of orally dosed ketamine and ketamine/medetomidine compared with intramuscular ketamine in rhesus macaques (Macaca mulatta) and the effects of dosing route on haematological stress markers. Bates, WA; Feng, C; Winterborn, AN; Wyatt, JD, 2008) | 0.85 |
| "Oral dosing alone was not sufficient to achieve a plane of sedation that allowed for safe handling." | ( The efficacy of orally dosed ketamine and ketamine/medetomidine compared with intramuscular ketamine in rhesus macaques (Macaca mulatta) and the effects of dosing route on haematological stress markers. Bates, WA; Feng, C; Winterborn, AN; Wyatt, JD, 2008) | 0.64 |
| " Leukogram profiles indicated that orally dosed animals experienced a higher level of stress." | ( The efficacy of orally dosed ketamine and ketamine/medetomidine compared with intramuscular ketamine in rhesus macaques (Macaca mulatta) and the effects of dosing route on haematological stress markers. Bates, WA; Feng, C; Winterborn, AN; Wyatt, JD, 2008) | 0.64 |
| "To describe intravenous ketamine dosing regimens for children requiring brief procedural sedation." | ( Dosing ketamine for pediatric procedural sedation in the emergency department. Anderson, BJ; Dallimore, D; Herd, DW; Short, T, 2008) | 1.11 |
| "5-h intervals) 12 h prior to the MDMA dosing regimen (20 mg/kg x 3 at 2-h intervals) aggravated the MDMA-induced dopaminergic toxicity." | ( Ketamine pretreatment exacerbated 3,4-methylenedioxymethamphetamine-induced central dopamine toxicity. Cherng, CG; Ho, MC; Ke, JJ; Tsai, CW; Tsai, YP; Yu, L, 2008) | 1.79 |
| " Administration and dosage of ketamine preceding the stimulation of dorsal roots was determined from the anesthetic record." | ( Does ketamine affect intraoperative electrophysiological monitoring in children undergoing selective posterior rhizotomy? Brown, K; Farmer, JP; Frigon, C; Poulin, C; Sedeek, K, 2008) | 1.15 |
| " Arterial rings were mounted in isolated tissue chambers equipped with isometric tension transducers to obtain pharmacologic dose-response curves." | ( N-methyl-D-aspartate (NMDA) antagonists--S(+)-ketamine, dextrorphan, and dextromethorphan--act as calcium antagonists on bovine cerebral arteries. Carlsson, C; Chen, D; Harakal, C; Kamel, IR; Wendling, KS; Wendling, WW, 2008) | 0.6 |
| " We conclude that a well-designed, randomized study of IV ketamine "bursts" in cancer patients suffering from depression is needed to further establish the role and appropriate dosing of ketamine in this patient population." | ( Intravenous ketamine "burst" for refractory depression in a patient with advanced cancer. Demas, M; Oneschuk, D; Stefanczyk-Sapieha, L, 2008) | 0.97 |
| " This study evaluated dose-response and time-course effects of ketamine, levels of ketamine in plasma and brain, and the relationship between altered NMDA receptor expression and ketamine-induced neuronal cell death during development." | ( Potential neurotoxicity of ketamine in the developing rat brain. Doerge, DR; Fu, X; Hanig, JP; Patterson, TA; Paule, MG; Sadovova, N; Slikker, W; Twaddle, NC; Wang, C; Zhang, X; Zou, X, 2009) | 0.89 |
| "75), high intravenous dosing (initial dose > or =2." | ( Predictors of airway and respiratory adverse events with ketamine sedation in the emergency department: an individual-patient data meta-analysis of 8,282 children. Agrawal, D; Brown, L; Garcia Pena, BM; Gerber, AC; Green, SM; Hostetler, MA; Krauss, B; Losek, JD; McGlone, RG; McKee, M; Pitetti, RD; Roback, MG; Treston, G; Wathen, JE; Weiss, M, 2009) | 0.6 |
| " Rats were trained on the task prior to drug exposure, after which they were subjected to one of two dosing regimes of ketamine (30 mg/kg twice a day for either 5 or 10 days)." | ( Disruptions in spatial working memory, but not short-term memory, induced by repeated ketamine exposure. Enomoto, T; Floresco, SB, 2009) | 0.78 |
| " The injection coordinates and the dosage of quinolinic acid were identical." | ( Ketamine anaesthesia interferes with the quinolinic acid-induced lesion in a rat model of Huntington's disease. Büchele, F; Döbrössy, M; Jiang, W; Nikkhah, G; Papazoglou, A, 2009) | 1.8 |
| "In conclusion, addition of low dose ketamine to propofol-fentanyl combination decreased the risk of desaturation and it also decreased the need for supplemental propofol dosage in pediatric patients at interventional radiology procedures." | ( Comparison of propofol-fentanyl with propofol-fentanyl-ketamine combination in pediatric patients undergoing interventional radiology procedures. Akinci, SB; Aypar, U; Erden, IA; Koseoglu, A; Pamuk, AG, 2009) | 0.88 |
| "The influence of increasing the dosage of ketamine on anaesthesia induced by a combination of ketamine, xylazine and midazolam in pigs was determined by assessing the onset of action (OAN), duration of analgesia (DAN), anaesthesia time (ANT), and recovery time (RCT) in 10 growing pigs (Mean weight: 18." | ( Increasing ketamine dose enhances the anaesthetic properties of ketamine-xylazine-midazolam combinations in growing pigs. Adeleye, OE; Ajadi, RA; Makinde, AF; Smith, OF, 2008) | 1 |
| "2-day intravenous infusion of low-dose ketamine (n=30) or placebo (n=30) using an individualized stepwise tailoring of dosage based on effect (pain relief) and side effects (nausea/vomiting/psychomimetic effects)." | ( Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1. Arbous, SM; Bauer, MCR; Dahan, A; Marinus, J; Sarton, EY; Sigtermans, MJ; van Hilten, JJ, 2009) | 2.06 |
| " The fentanyl was used systematically during induction at the dosage of 5 microg/kg." | ( [Prevention of the acute tolerence with fentanyl by ketamine]. Diatta, B; Khalil, Y; Ndiaye, M; Ndoye Diop, M; Niang, B; Seck, M; Wade, A; Wade, KH, 2008) | 0.6 |
| " The ELISA kit was validated to include an assessment of the dose-response curve, intra- and interday precision, limit of detection (LOD), and cross-reactivity." | ( Validation of an enzyme-linked immunosorbent assay screening method and a liquid chromatography-tandem mass spectrometry confirmation method for the identification and quantification of ketamine and norketamine in urine samples from Malaysia. Anderson, RA; Harun, N; Miller, EI, ) | 0.32 |
| "Although the dosage and duration of ketamine abuse causing severe side-effects are still unclear, some patients develop irreversible histological changes in the urinary tract." | ( Ketamine-associated bladder dysfunction. Cha, TL; Chang, SY; Chuang, FP; Lin, CM; Sun, GH; Tang, SH; Tsai, TH; Tsao, CW; Wu, ST; Yu, DS, 2009) | 2.07 |
| " Higher dosing elicited significantly more side effects." | ( Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain. Azad, SC; Beyer, A; Huge, V; Lauchart, M; Magerl, W; Schelling, G; Thieme, D, 2010) | 0.64 |
| " Therefore, we tested the dose-response direct cardiac effects of clinically available induction agents in an isolated septic rat heart model." | ( Cardiac effects of induction agents in the septic rat heart. Busse, H; Graf, BM; Lunz, D; Sinner, B; Zausig, YA; Zink, W, 2009) | 0.35 |
| " In the present retrospective study we evaluated the impact of these vendor changes on ketamine dosing to establish anaesthesia, on pilocarpine-induced seizure susceptibility, and on basal extracellular hippocampal noradrenaline, dopamine, serotonin, gamma-amino butyric acid, and glutamate levels of all pilocarpine-treated rats included in our studies." | ( Intrastrain differences in seizure susceptibility, pharmacological response and basal neurochemistry of Wistar rats. Aourz, N; Clinckers, R; De Bundel, D; Meurs, A; Michotte, Y; Portelli, J; Smolders, I, 2009) | 0.58 |
| " There was no consistent dose-response relation." | ( Use of oral ketamine in chronic pain management: a review. Blonk, MI; Huygen, FJ; Koder, BG; van den Bemt, PM, 2010) | 0.74 |
| " Assessments of psychological wellbeing showed greater dissociative symptoms in frequent users and a dose-response effect on delusional symptoms, with frequent users scoring higher than infrequent, abstinent users and non-users, respectively." | ( Consequences of chronic ketamine self-administration upon neurocognitive function and psychological wellbeing: a 1-year longitudinal study. Curran, HV; Morgan, CJ; Muetzelfeldt, L, 2010) | 0.67 |
| " The ketamine groups were administered intraperitoneally with low dosage (25 mg/kg), middle dosage (50 mg/kg) and high dosage (100 mg/kg) one time every day for 7 days." | ( [The correlation between ketamine-induced schizophrenia-like signs in mice and the expressions of NRG1, ErbB4 mRNA]. Bian, SZ; Gu, ZL; Guo, CY; Jiang, XG; Liu, WL; Zhang, ZX, 2009) | 1.17 |
| "In the group with high dosage of ketamine, the levels of NRG1 and ErbB4 mRNA were significantly lower than that of the group with saline." | ( [The correlation between ketamine-induced schizophrenia-like signs in mice and the expressions of NRG1, ErbB4 mRNA]. Bian, SZ; Gu, ZL; Guo, CY; Jiang, XG; Liu, WL; Zhang, ZX, 2009) | 0.94 |
| " The onset depends on the dosage used." | ( Rapid sequence intubation: a review of recent evidences. Di Filippo, A; Gonnelli, C, 2009) | 0.35 |
| " ZL-n-91 (3 microg, 10 microg, 30 microg kg(-1)) dose-dependently reduced the total leukocyte number, neutrophil number and total protein content in BALF, MPO activity, TNF-alpha level and cAMP-PDE, PDE4 activity in lung homogenate, but the effect of ZL-n-91 in pathological changes and lung wet w/d ratio is slight; Rol and Dex significantly reduced lung wet w/d ratio and improved pathological changes, neutrophil around the pulmonary vessel and airway significantly reduced, symptoms of lung edema relieved; The PH value, P(a)O(2) and P(a)CO(2) in ZL-n-91 high dosage group and Rol group had changes, but there was no significant difference compared with LPS group or saline group; After the administration, the righting reflex recovery time significantly shorten in every group of ZL-n-91." | ( Action of a Novel PDE4 inhibitor ZL-n-91 on lipopolysaccharide-induced acute lung injury. Chen, JQ; Liang, YQ; Lu, JJ; Mao, LG; Tang, HF; Tang, JF; Wang, XF; Wang, YJ; Zheng, X, 2010) | 0.36 |
| " However, the mean propofol dosage was higher in group 2 (33." | ( Comparison of two ketamine-propofol dosing regimens for sedation during interventional radiology procedures. Akinci, SB; Aypar, U; Erden, IA; Koseoglu, A; Pamuk, AG, 2010) | 0.69 |
| " With intravenous administration the onset of action is within 1 min and the effects last for about 5 to 10 min, depending on dosage level and individual variation." | ( Taming the ketamine tiger. 1965. Domino, EF, 2010) | 0.75 |
| " In a setting where efficacy and safety of the agent are paramount, there are conflicting recommendations in terms of optimal mode of parenteral administration, as well as optimal dosage and need for the coadministration of adjunctive agents to decrease side effects." | ( Intravenous vs intramuscular ketamine for pediatric procedural sedation by emergency medicine specialists: a review. Babl, FE; Deasy, C, 2010) | 0.65 |
| " Loss of efficacy (tolerance) followed by enhanced pain sensitivity occurred with repeated dosing of buprenorphine." | ( Buprenorphine-induced hyperalgesia in the rat. Holtman, JR; Wala, EP, 2011) | 0.37 |
| "We sought to extend past findings by examining dose-response curves that overlap with the individual doses previously reported to induce lasting effects in rodents and determining whether effects generalize to the tail suspension test (TST) and Balb/cJ mice." | ( CD-1 and Balb/cJ mice do not show enduring antidepressant-like effects of ketamine in tests of acute antidepressant efficacy. Bechtholt-Gompf, AJ; Carlezon, WA; Cohen, BM; John, CS; Kang, HH; Ongür, D; Smith, KL, 2011) | 0.6 |
| " We analysed the number of sessions until completion of ECT treatment (used as a surrogate parameter for outcome), psychopathology as assessed by pre- and post-ECT Mini-Mental State Examination (MMSE) and Hamilton Rating Scale for Depression (HAM-D) scores as well as ECT and seizure parameters (stimulation dose, seizure duration and concordance, urapidil dosage for post-seizure blood pressure management)." | ( Clinically favourable effects of ketamine as an anaesthetic for electroconvulsive therapy: a retrospective study. Hoyer, C; Kammerer-Ciernioch, J; Kranaster, L; Sartorius, A, 2011) | 0.65 |
| "), respectively, to male ICR mice to determine the optimal dosage for chronic administration." | ( Ketamine effects on the urogenital system--changes in the urinary bladder and sperm motility. Chan, WM; Hui, LK; Hui, VW; James, AE; Tan, S; Wai, MS; Yeung, LY; Yew, DT, 2011) | 1.81 |
| "Our objective was to investigate the efficacy and the optimum dosage of ketamine for post anesthetic shivering prevention." | ( Optimum dose of ketamine for prevention of postanesthetic shivering; a randomized double-blind placebo-controlled clinical trial. Doroodian, MR; Norouzi, M; Salajegheh, S, 2011) | 0.95 |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | ( FDA-approved drug labeling for the study of drug-induced liver injury. Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) | 0.37 |
| "Administration of a subanesthetic dosage of ketamine with xylazine and butorphanol may facilitate certain procedures, such as insertion of a dental float, in horses and enhance tolerance to pressure stimulation, but it may worsen responses to acute pain, such as that caused by a needle prick." | ( Evaluation of sedation and analgesia in standing horses after administration of xylazine, butorphanol, and subanesthetic doses of ketamine. Contino, EK; Ferris, DJ; Kawcak, CE; Mama, KR; Wagner, AE, 2011) | 0.84 |
| " It also enabled a reduction in the intrathecal opioid dosage leading to a resolution of the acute symptoms attributed to OIH." | ( Successful reversal of hyperalgesia/myoclonus complex with low-dose ketamine infusion. Chan, PS; Forero, M; Restrepo-Garces, CE, 2012) | 0.61 |
| " The findings suggest that the dosage of S-ketamine should be reduced in patients receiving ticlopidine." | ( Exposure to oral S-ketamine is unaffected by itraconazole but greatly increased by ticlopidine. Hagelberg, NM; Laine, K; Neuvonen, PJ; Olkkola, KT; Peltoniemi, MA; Reponen, P; Saari, TI; Turpeinen, M, 2011) | 0.96 |
| " Optimal dosing titration, duration of initial treatment, and the role of maintenance ketamine need to be further elucidated." | ( The use of ketamine in severe cases of refractory pain syndromes in the palliative care setting: a case series. Holahan, T; Kerr, C; Milch, R, 2011) | 0.98 |
| "The purpose of this study was to examine the effects of a clinically relevant opioid on the production of augmented breaths (ABs) in unanesthetized animals breathing normal room air, using a dosage which does not depress breathing." | ( The "other" respiratory effect of opioids: suppression of spontaneous augmented ("sigh") breaths. Azubike, E; Bell, HJ; Haouzi, P, 2011) | 0.37 |
| "67) ketamine, respectively within the recommended dosage guidelines." | ( Ketamine and midazolam sedation for pediatric gastrointestinal endoscopy in the Arab world. Abdelhadi, R; Gilger, MA; Hayajneh, WA; Miqdady, MI, 2011) | 2.37 |
| " Use of the combination requires the development of standardized protocols for drug preparation and dosage to minimize the potential for errors." | ( Combination of ketamine and propofol versus either agent alone for procedural sedation in the emergency department. Jennett-Reznek, AM; Patanwala, AE; Thomas, MC, 2011) | 0.72 |
| " The aim of this study was to evaluate the effect of oral ketamine on the dosage of local anesthetics required and postoperative pain management for irreversibly inflamed mandibular molars." | ( The effect of orally administered ketamine on requirement for anesthetics and postoperative pain in mandibular molar teeth with irreversible pulpitis. Ebtehaj, I; Kaviani, N; Khademi, A; Mohammadi, Z, 2011) | 0.89 |
| " Whereas ketamine produced progressive increases in activity with repeated administration in rats of both ages, MDMA increased, and then decreased, activity in the chronic dosing regimen in female adolescents only." | ( Locomotor activity changes in female adolescent and adult rats during repeated treatment with a cannabinoid or club drug. Evans, RL; Grainger, DB; Nicholson, KL; Wiley, JL, 2011) | 0.79 |
| " Skunks were immobilized with a mean (±SD) dosage of 24." | ( Field immobilization of Molina's hog-nosed skunk (Conepatus chinga) using ketamine and xylazine. Casanave, EB; Castillo, DF; Lucherini, M; Vidal, EL, 2012) | 0.61 |
| " They have been shown to help in reaching the desired effect when administered at drug-specific modes and at proven effective dosing throughout the perioperative period." | ( Non-opioid IV adjuvants in the perioperative period: pharmacological and clinical aspects of ketamine and gabapentinoids. Weinbroum, AA, 2012) | 0.6 |
| " In this report we have used the murine model of tularemia, with Francisella tularensis live vaccine strain (FTLVS) infection, to evaluate the efficiency of pneumonic delivery via intranasal dosing performed either with differing instillation volumes or different types of anesthesia." | ( Visualization of murine intranasal dosing efficiency using luminescent Francisella tularensis: effect of instillation volume and form of anesthesia. Bina, JE; Bina, XR; Fabrizio, TP; Miller, MA; Parvathareddy, J; Stabenow, JM; Wodowski, AJ; Zalduondo, L, 2012) | 0.38 |
| " Sixty-five (46%) patients receiving ketofol and 93 (65%) patients receiving propofol required repeated medication dosing or progressed to a Ramsay Sedation Score of 4 or less during their procedure (difference 19%; 95% confidence interval 8% to 31%; P=." | ( Ketamine-propofol combination (ketofol) versus propofol alone for emergency department procedural sedation and analgesia: a randomized double-blind trial. Abu-Laban, RB; Andolfatto, G; Moadebi, S; Stackhouse, S; Staniforth, SM; Willman, E; Zed, PJ, 2012) | 1.82 |
| " VAS and whole dosage of morphine were compared between two groups every 6 hours." | ( Analgesic effects of ketamine infusion on postoperative pain after fusion and instrumentation of the lumbar spine: a prospective randomized clinical trial. Abrishamkar, S; Eshraghi, N; Feizi, A; Rafiei, A; Rahmani, P; Talakoub, R, 2012) | 0.7 |
| " In dose-response experiments, cultured neural stem progenitor cells were exposed to different concentrations of ketamine (0-100 µM) for 24 hrs." | ( Ketamine alters the neurogenesis of rat cortical neural stem progenitor cells. Anand, KJ; Dong, C; Rovnaghi, CR, 2012) | 2.03 |
| " Future studies should further examine the anti-inflammatory effect of ketamine during major surgery, determine whether ketamine treatment alters functional outcomes, elucidate the mechanisms of its anti-inflammatory effect, and suggest an appropriate dosing regimen." | ( Does intraoperative ketamine attenuate inflammatory reactivity following surgery? A systematic review and meta-analysis. Dale, O; Li, Y; Shavit, Y; Somogyi, AA; Sullivan, T, 2012) | 0.94 |
| " The dosage of 5 mg ketamine/kg body mass was rarely sufficient to obtain surgical tolerance in group INJE." | ( [Comparison of three different anesthesia procedures in calves with respect to possible pain-associated reactions]. Hefti, A; Metzner, M; Sauter-Louis, C; Schlemmer, I, ) | 0.45 |
| " The examination of ketamine with relevance to the above topics has produced valuable data; however, there exists a great deal of variability in the literature regarding dosage and timing of administration to examine ketamine-induced deficits." | ( Examination of ketamine-induced deficits in sensorimotor gating and spatial learning. Bolton, MM; Heaney, CF; Kinney, JW; Murtishaw, AS; Sabbagh, JJ, 2012) | 1.06 |
| " Repeated benzodiazepine dosing or combined application of benzodiazepines and NMDA receptor antagonists is more likely to be effective in treating TMDT poisoning." | ( Differential antagonism of tetramethylenedisulfotetramine-induced seizures by agents acting at NMDA and GABA(A) receptors. Shakarjian, MP; Stanton, PK; Velíšek, L; Velíšková, J, 2012) | 0.38 |
| " A variety of medications have been used for RSI, with potential for inadequate or excessive dosing as well as complications including hypotension and the need for redosing." | ( A standardized rapid sequence intubation protocol facilitates airway management in critically injured patients. Anderson, S; Ballow, SL; Chang, M; Kaups, KL, 2012) | 0.38 |
| " It also reviews the comparative pharmacokinetics, adverse effects, and dosing of ketamine, propofol, and ketofol as agents for procedural sedation and analgesia." | ( Ketamine, propofol, and ketofol use for pediatric sedation. Alletag, MJ; Auerbach, MA; Baum, CR, 2012) | 2.05 |
| "A prospective study was performed on 12 children with chronic pain to identify the maximum tolerated dosage of oral ketamine." | ( Oral ketamine for children with chronic pain: a pilot phase 1 study. Adams, HR; Bredlau, AL; Dolan, JG; Dworkin, RH; Fisher, SG; Korones, DN; McDermott, MP; Venuto, C, 2013) | 1.11 |
| " The present work investigated the effect of ketamine on the development of Lucilia sericata (Meigen) (Diptera: Calliphoridae) by the measurement of body length and weight and the analysis of relationship between the ketamine effect and drug dosage or time interval, meanwhile the difference between ketamine effect on larval body length and weight was also analyzed." | ( Effect of ketamine on the development of Lucilia sericata (Meigen) (Diptera: Calliphoridae) and preliminary pathological observation of larvae. Huang, M; Huang, R; Huang, X; Lin, J; Qiu, X; Wu, X; You, Z; Zhang, S; Zou, Y, 2013) | 1.05 |
| "5 mg/kg over 40 minutes, some preliminary evidence suggests other dosing regimens and routes of administration may be useful or even better." | ( Ketamine as a new treatment for depression: a review of its efficacy and adverse effects. Glue, P; Katalinic, N; Lai, R; Loo, CK; Mitchell, PB; Somogyi, A, 2013) | 1.83 |
| " clinical, genetic, pharmacokinetic, environmental), examining different dosing regimens and routes of administration, and strategies to maintain the antidepressant response." | ( Ketamine as a new treatment for depression: a review of its efficacy and adverse effects. Glue, P; Katalinic, N; Lai, R; Loo, CK; Mitchell, PB; Somogyi, A, 2013) | 1.83 |
| " All data were recorded concerning the initial and total dosage of analgesic and the presence of complications within 24 hrs." | ( [A comparison of the effects of intraoperative tramadol and ketamine usage for postoperative pain relief in patients undergoing tonsillectomy]. Çelik, JB; Kara, I; Sizer, Ç; Topal, A, 2013) | 0.63 |
| " Paracetamol dosage was significantly higher in the control group (p<0." | ( [A comparison of the effects of intraoperative tramadol and ketamine usage for postoperative pain relief in patients undergoing tonsillectomy]. Çelik, JB; Kara, I; Sizer, Ç; Topal, A, 2013) | 0.63 |
| " Notably, an unacceptable long recovery period in both ketamine/medetomidine protocols (subsequently reversed with atipamezole) was observed, showing that α-2 adrenoreceptor agonists in the used dose and dosing regime is not the first choice for sedation in common marmosets in a standard research setting." | ( Comparison of three different sedative-anaesthetic protocols (ketamine, ketamine-medetomidine and alphaxalone) in common marmosets (Callithrix jacchus). Bakker, J; Brok, HP; Langermans, JA; Pelt, ER; Remarque, EJ; Uilenreef, JJ, 2013) | 0.88 |
| " Additional bolus/es was/were administered in the dosage similar to induction dose in case of inadequate sedation." | ( A double blind randomized trial of ketofol versus propofol for endodontic treatment of anxious pediatric patients. Gauba, K; Goyal, A; Jain, K; Kapur, A; Mittal, N, 2013) | 0.39 |
| " A safe and effective dosage of xylazine-ketamine for Indian fox (Vulpes bengalensis) is reported, based on 37 wild Indian fox immobilizations between April 2006 and May 2007." | ( Use of xylazine hydrochloride-ketamine hydrochloride for immobilization of Indian fox (Vulpes bengalensis) in field situations. Belsare, AV; Vanak, AT, 2013) | 0.94 |
| " En résumé, l'application de S-kétamine à un dosage correspondant à 60% de celui de la kétamine racémique produit une anesthésie similaire." | ( Racemic ketamine in comparison to S-ketamine in combination with azaperone and butorphanol for castration of pigs. Bettschart-Wolfensberger, R; Flaherty, D; Hässig, M; Ringer, SK; Stauffer, S, 2013) | 0.82 |
| " These data also suggest the existence of an inverted-U dose-response curve in the potential therapeutic effect of this class of compounds." | ( Relationship between glycine transporter 1 inhibition as measured with positron emission tomography and changes in cognitive performances in nonhuman primates. Carson, RE; Castner, SA; Gunn, RN; Herdon, H; Huang, Y; Laruelle, M; Murthy, NV; Rabiner, EA; Ridler, K; Roberts, BM; Weinzimmer, DP; Williams, GV; Zheng, MQ, 2014) | 0.4 |
| " It is concluded also that the increase of cortisol is likely to be more a side effect of Ketamine/Norketamine than the expression of distress by surgical interventions or by wake-up reactions, and that an intoxication by additional Ketamine dosage or motoric disorders (i." | ( [Perioperative intensive-medical investigations regarding compatibility of the ketamine-azaperone-general anesthesia in pigs]. Baars, J; Lahrmann, KH; Rintisch, U, ) | 0.58 |
| " The second experiment examined effects of repeated dosing with ketamine (3." | ( Dissociable effects of the noncompetitive NMDA receptor antagonists ketamine and MK-801 on intracranial self-stimulation in rats. Hillhouse, TM; Negus, SS; Porter, JH, 2014) | 0.88 |
| " Repeated dosing with ketamine produced dose-dependent tolerance to the rate-decreasing effects of ketamine (10." | ( Dissociable effects of the noncompetitive NMDA receptor antagonists ketamine and MK-801 on intracranial self-stimulation in rats. Hillhouse, TM; Negus, SS; Porter, JH, 2014) | 0.95 |
| " To ensure a safe dosing the age, body weight, duration of therapy, maximum daily dose and dosing intervals must be taken into account." | ( [Pediatric perioperative systemic pain therapy: Austrian interdisciplinary recommendations on pediatric perioperative pain management]. Grögl, G; Jaksch, W; Messerer, B; Stromer, W, 2014) | 0.4 |
| " The mean midazolam dosage administered was 1 ± 0." | ( [Prehospital analgesia performed by paramedics: quality in processes and effects under medical supervision]. Gaier, G; Häske, D; Niederberger, C; Schempf, B, 2014) | 0.4 |
| " Doses explored during dose-ranging included 20, 40, 100, or 200 mg/kg ketamine; subsequent withdrawal assessments were conducted following repeat dosing of 150 mg/kg." | ( Withdrawal assessment following subchronic oral ketamine administration in Cynomolgus macaques. Carfagna, MA; Kallman, MJ; Koger, D; Sgro, M; Walgren, JL, 2014) | 0.89 |
| " It is therefore necessary to investigate ketamine locally and systematically with various dosing schedules in order to reduce the bladder damage secondary to oxazaphosphorine-alkylating agents and these results may widen the spectrum of ketamine." | ( Protective effect of ketamine against hemorrhagic cystitis in rats receiving ifosfamide. Onag, A; Ozguven, AA; Taneli, F; Ulman, C; Vatansever, S; Yılmaz, O, ) | 0.71 |
| " Nonetheless, an adequate dosage and way of administration should be considered and established for human use." | ( The effect of ketamine on optical and electrical characteristics of spreading depolarizations in gyrencephalic swine cortex. Orakcioglu, B; Sakowitz, OW; Sánchez-Porras, R; Santos, E; Schiebel, P; Schöll, M; Stock, C; Unterberg, AW; Zheng, Z, 2014) | 0.76 |
| "2 mg/kg) increased the GBO power, exhibiting an inverted U-shape dose-response curve; at higher doses (0." | ( Differential effects of NMDA receptor antagonists at lower and higher doses on basal gamma band oscillation power in rat cortical electroencephalograms. Chaki, S; Hiyoshi, T; Kambe, D; Karasawa, J, 2014) | 0.4 |
| "This is the first trial to present dose-response data of ketamine efficacy and psychomimetic effects in depressed subjects." | ( Pilot dose-response trial of i.v. ketamine in treatment-resistant depression. Glue, P; Harper, S; Katalinic, N; Lai, R; Leyden, J; Loo, CK; Mitchell, PB; Somogyi, AA, 2014) | 0.93 |
| "Continuous pump infusion of 1 mg/(kg x h) ketamine for TIVA in adults can reduce dosage of propofol and minimize adverse effects of ketamine." | ( [Determination of dosage and effectiveness of propofol and ketamine for TIVA in adults]. Kang, Y; Li, XQ; Li, Y; Liu, J, 2014) | 0.91 |
| " In controlled trials of neuropathic pain with topical ketamine combinations, there were improvements in some outcomes, but optimal dosing and drug combinations were not clear." | ( Topical and peripheral ketamine as an analgesic. Sawynok, J, 2014) | 0.96 |
| " This study aimed to investigate how a chronic antipsychotic dosing regimen affects ongoing cortical γ oscillations, and the electrophysiological and behavioural responses induced by the NMDAr antagonist ketamine." | ( Chronic administration of antipsychotics attenuates ongoing and ketamine-induced increases in cortical γ oscillations. Anderson, PM; Jones, NC; O'Brien, TJ; Pinault, D, 2014) | 0.83 |
| " Pharmacokinetic blood sampling and local tolerability and safety assessments were carried out during 24 h following both dosing occasions." | ( The absolute bioavailability of racemic ketamine from a novel sublingual formulation. Lim, S; Liu, Y; Molnar, V; Rolan, P; Sunderland, V, 2014) | 0.67 |
| " Additional research is required to determine optimal dosing schedules, route, treatment schedules, and the potential efficacy of other glutamatergic agents." | ( A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes. Berlim, MT; Bond, DJ; Fleck, MP; Lam, RW; McGirr, A; Yatham, LN, 2015) | 0.64 |
| " Highly variable timing and dosing of ketamine in these studies suggest that no unifying effective regimen has emerged." | ( A systematic review and meta-analysis of ketamine for the prevention of persistent post-surgical pain. Haroutounian, S; McNicol, ED; Schumann, R, 2014) | 0.94 |
| " The use of weight-based dosing of IV continuous infusion and transition to oral ketamine was effective and tolerable in the management of opioid-refractory, neuropathic cancer pain." | ( Case report: efficacy and tolerability of ketamine in opioid-refractory cancer pain. Amin, P; Atayee, R; Roeland, E, 2014) | 0.89 |
| " However, before these agents are recommended for general use, large multicenter trials should be done exploring not only efficacy but also dose-response relationships and side effects." | ( Novel preoperative pharmacologic methods of preventing postoperative sore throat due to tracheal intubation. Austin, PN; Kalil, DM; Silvestro, LS, 2014) | 0.4 |
| "To provide additional data about the clinical efficacy and dosing range for ketamine used as the induction agent in electroconvulsive therapy (ECT)." | ( Dosing and effectiveness of ketamine anesthesia for electroconvulsive therapy (ECT): a case series. Ahle, GM; Aloysi, AS; Bryson, EO; Kellner, CH; Lapidus, KA; Liebman, LS; Majeske, MF, 2014) | 0.93 |
| " We extracted clinical data about antidepressant response as well as absolute and weight-based dosing for ketamine." | ( Dosing and effectiveness of ketamine anesthesia for electroconvulsive therapy (ECT): a case series. Ahle, GM; Aloysi, AS; Bryson, EO; Kellner, CH; Lapidus, KA; Liebman, LS; Majeske, MF, 2014) | 0.91 |
| " We aimed to determine a ketofol dosing regimen for short procedural sedation and analgesia of 5- to 20-minute duration in healthy patients (2-20 y)." | ( Ketofol dosing simulations for procedural sedation. Anderson, BJ; Coulter, FL; Hannam, JA, 2014) | 0.4 |
| "Methamphetamine (4mg/kg)-induced place preference mice model was successfully established; ketamine (15mg/kg), rhynchophylline (40mg/kg) and rhynchophylline (80mg/kg) can eliminate place preference; Immunohistochemistry showed that the number of NR2B-positive neurons in hippocampus was increased in the methamphetamine model group, whereas less NR2B-positive neurons were found in the ketamine group, low and high dosage rhynchophylline group." | ( Effect of rhynchophylline on conditioned place preference on expression of NR2B in methamphetamine-dependent mice. Fang, M; Guo, Y; Jiang, M; Li, J; Liu, W; Liu, Y; Luo, C; Mo, Z; Peng, Q, 2014) | 0.62 |
| " In dose-response experiments, cultured neural stem cells (NSCs) were exposed to different concentrations of ketamine (0-1000 µM) for 24 hrs." | ( Ketamine inhibits proliferation of neural stem cell from neonatal rat hippocampus in vitro. Hu, Y; Huang, H; Huang, L; Liang, T; Liu, L; Shi, XT; Wu, YQ; Xu, CM; Zhao, PP; Zhou, CH; Zhu, YZ, 2014) | 2.06 |
| " Systemic nicotine given before the sample phase of the CMOR task reversed the ketamine-induced impairment, but this effect was blocked by co-administration of the GABAA receptor antagonist bicuculline at a dosage that itself did not cause impairment." | ( α₄β₂ Nicotinic receptor stimulation of the GABAergic system within the orbitofrontal cortex ameliorates the severe crossmodal object recognition impairment in ketamine-treated rats: implications for cognitive dysfunction in schizophrenia. Cloke, JM; Winters, BD, 2015) | 0.84 |
| " Additional studies are needed to evaluate the dosing schemes and long-term outcomes of dexmedetomidine premedication in pediatric anesthesia." | ( Premedication with dexmedetomidine in pediatric patients: a systematic review and meta-analysis. Ji, FH; Li, J; Peng, K; Wu, SR, 2014) | 0.4 |
| " The procedure was assessed by way ofaphysician-completed form and by evaluation of questionnaires given to parents to estimate levels of pain by using a 0 to 10 mm visual analog scale (VAS) at 2 hours after procedures and results in any adverse events with respect to age, gende, procedures performed, ketamine dosage and recovery time." | ( The factors of ketamine that affect sedation in children with oncology procedures: parent satisfaction perspective. Jindakam, W; Lumkul, R; Monsereenusorn, C; Rujkijyanont, P; Traivaree, C, 2014) | 0.93 |
| " Important questions are as follows: is it specific or coincidental to other effects; is there a dose-response relationship; and is the mechanism related to that of current antidepressants." | ( Rapid-onset antidepressant action of ketamine: potential revolution in understanding and future pharmacologic treatment of depression. Drewniany, E; Han, J; Hancock, C; Jones, RL; Lim, J; Nemat Gorgani, N; Raffa, RB; Sperry, JK; Yu, HJ, 2015) | 0.69 |
| " The depression model of mice was developed by continuously oral administration of low dosage of corticosterone (CORT)." | ( [Inhibition of HCN1 channels by ketamine accounts for its antidepressant actions]. Chen, FF; Chen, XD; Li, J; Zhou, C, 2014) | 0.69 |
| " Furthermore, NMDA (N-methyl-d-aspartate) receptor antagonism by ketamine had an opposing dose-dependent effect, suggesting that the differential dosage of ketamine might have divergent effects on behavioral processes." | ( Inhibition of parvalbumin-expressing interneurons results in complex behavioral changes. Báldi, R; Brown, JA; Everheart, MG; Garbett, K; Gellért, L; Horváth, S; Mirnics, K; Patel, S; Ramikie, TS; Schmidt, MJ; Warren, LE, 2015) | 0.65 |
| " Cohorts were compared on the basis of the number of doses, mg/kg administered, total dosage (mg), and adverse events." | ( A retrospective comparison of ketamine dosing regimens for pediatric procedural sedation. Chang, TP; Heilbrunn, BR; Liu, DR, 2015) | 0.71 |
| "0 had a higher median overall mg/kg dosage (1." | ( A retrospective comparison of ketamine dosing regimens for pediatric procedural sedation. Chang, TP; Heilbrunn, BR; Liu, DR, 2015) | 0.71 |
| " However, the optimal dosing and route of administration and the safety of chronic treatment are not fully known." | ( Ketamine as a promising prototype for a new generation of rapid-acting antidepressants. Abdallah, CG; Averill, LA; Krystal, JH, 2015) | 1.86 |
| " Using extracellular field recordings in rat hippocampal slices, we show that a single dose of the non-selective NMDA receptor antagonist ketamine or CP-101,606, a selective antagonist of the NR2B subunit of the NMDA receptor, enhances hippocampal synaptic plasticity induced with high frequency stimulation (HFS) 24h after dosing - a time at which plasma concentrations of the drug are no longer detectable in the animal." | ( Effect of acute NR2B antagonist treatment on long-term potentiation in the rat hippocampus. Bristow, LJ; Graef, JD; Kiss, L; Li, YW; Luan, FN; Luchetti, D; Newberry, K; Newton, A; Pieschl, R; Schaeffer, E; Shields, E; Simmermacher, J, 2015) | 0.62 |
| " These findings are consistent with the hypothesis that the inability of memantine, AZD6765 (lanicemine) and MK-0657 to reproduce the rapid and robust antidepressant effects of ketamine in the clinic result from insufficient dosing rather than a difference in mechanism of action among these NMDAR antagonists." | ( Effect of NMDAR antagonists in the tetrabenazine test for antidepressants: comparison with the tail suspension test. Czekaj, J; Kos, T; Popik, P; Skolnick, P, 2015) | 0.61 |
| " The combined ketamine and transcranial magnetic stimulation treatment was administered a total of 24 times over five months, with his ketamine dosage increased from 50mg at the first treatment to 600 mg by the last." | ( Ketamine and transcranial magnetic stimulation treatment for bipolar II disorder: a case report. Best, SR; Griffin, BP; Pavel, DG, 2015) | 2.22 |
| " The serendipitous finding of rapid-onset antidepressant action of subanaesthetic dosing with ketamine by intravenous infusion has sparked many preclinical and clinical investigations." | ( Ketamine and suicidal ideation in depression: Jumping the gun? Dawe, GS; Fam, J; Rajkumar, R; Yeo, EY, 2015) | 2.08 |
| " This suggests that researchers should fully explore dose-response relationships in their strain of choice and use care in the interpretation of reversal of cognitive impairment." | ( Cross-site strain comparison of pharmacological deficits in the touchscreen visual discrimination test. Chapin, D; Ding, Z; Kozak, R; Mohler, EG; Rueter, LE; Young, D, 2015) | 0.42 |
| "We report a case of opioid-induced neurotoxicity (OIN) in an actively dying hospice patient, its reversal and improved analgesia that followed opioid dosage reduction made possible after addition of IV ketamine." | ( Intravenous Ketamine for Rapid Opioid Dose Reduction, Reversal of Opioid-Induced Neurotoxicity, and Pain Control in Terminal Care: Case Report and Literature Review. Bradshaw, YS; Carr, DB; Winegarden, J, 2016) | 1 |
| " The dose-response relationships of all 3 compounds in the forced swim test were also investigated in mice 30 min after IP administration." | ( Antidepressant-like effects of ketamine, norketamine and dehydronorketamine in forced swim test: Role of activity at NMDA receptor. Drabik, U; Gajdosz, R; Librowski, T; Nowak, G; Popik, P; Sałat, K; Siwek, A; Starowicz, G, 2015) | 0.7 |
| " As expected, the model does not provide good fits to the HFO power after dosing the pure NMDAR antagonist MK-801." | ( A PK-PD model of ketamine-induced high-frequency oscillations. Brown, EN; Ching, S; Fath, AB; Flores, FJ; Hartnack, K; Purdon, PL; Wilson, MA, 2015) | 0.76 |
| " Further research is warranted to elucidate the optimal timing and dosing of IA ketamine and morphine for postoperative analgesic effects." | ( Effect of preemptive intra-articular morphine and ketamine on pain after arthroscopic rotator cuff repair: a prospective, double-blind, randomized controlled study. Amar, E; Chechik, O; Dolkart, O; Khashan, M; Maman, E; Mozes, G; Sharfman, Z; Weinbroum, A, 2016) | 0.91 |
| " Predefined subgroup analyses and meta-regression did not detect significant differences across subgroups, including a dose-response relationship." | ( Ketamine added to morphine or hydromorphone patient-controlled analgesia for acute postoperative pain in adults: a systematic review and meta-analysis of randomized trials. Cheng, D; Johnston, B; Kaushal, A; Martin, J; Wang, L; Zhu, F, 2016) | 1.88 |
| " Results Potential avenues investigated to minimise psychotomimetic effects associated with ketamine administration include the following: (1) altering dosing and infusion rates; (2) route of administration; (3) enantiomer choice; (4) co-administration with mood stabilisers of antipsychotics; and (5) use of alternative N-methyl-d-aspartate (NMDA)-modulating agents." | ( Strategies to mitigate dissociative and psychotomimetic effects of ketamine in the treatment of major depressive episodes: a narrative review. Cha, DS; Cooper, MD; Kakar, R; Lee, Y; McIntyre, RS; Rosenblat, JD, 2017) | 0.91 |
| " The higher ketamine use frequency and dosage were associated with more severe depressive symptoms." | ( Profiling the psychotic, depressive and anxiety symptoms in chronic ketamine users. Deng, X; Ding, Y; Fan, N; He, H; Ke, X; Ning, Y; Rosenheck, R; Sun, B; Tang, W; Wang, D; Xu, K; Zhou, C, 2016) | 1.05 |
| "To review the literature about the dosing regimen, duration, effects and side-effects of oral, intravenous, intranasal and subcutaneous routes of administration of ketamine for treatment-resistant depression and pain." | ( Oral ketamine for the treatment of pain and treatment-resistant depression†. aan het Rot, M; Balukova, SM; Chaves, TV; Kortekaas, R; Schoevers, RA, 2016) | 1.14 |
| " We reviewed all papers for information about dosing regimen, number of individuals who received ketamine, number of ketamine days per study, results and side-effects, as well as study quality." | ( Oral ketamine for the treatment of pain and treatment-resistant depression†. aan het Rot, M; Balukova, SM; Chaves, TV; Kortekaas, R; Schoevers, RA, 2016) | 1.17 |
| "Use of ketamine in patients requiring extracorporeal membrane oxygenation (ECMO) has rarely been reported, and the optimal dosing strategy remains unclear." | ( High-Dose Sedation and Analgesia During Extracorporeal Membrane Oxygenation: A Focus on the Adjunctive Use of Ketamine. Cochran, JB; Floroff, CK; Hassig, TB; Mazur, JE, 2016) | 1.1 |
| " Although current antidepressants, such as serotonin-reuptake inhibitors, produce subtle changes that take effect in weeks or months, it has recently been shown that treatment with new agents results in an improvement in mood ratings within hours of dosing patients who are resistant to typical antidepressants." | ( Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Aghajanian, GK; Duman, RS; Krystal, JH; Sanacora, G, 2016) | 0.43 |
| " In this study, daily administration of a low dose of (R,S)-Ket for 14-days to Wistar rats was conducted to determine the impact of sub-chronic dosing on the pharmacokinetics of (R,S)-Ket and its major metabolites." | ( Subchronic administration of (R,S)-ketamine induces ketamine ring hydroxylation in Wistar rats. Green, C; Jozwiak, K; Moaddel, R; O'Loughlin, K; Ramamoorthy, A; Sanghvi, M; Singh, N; Torjman, M; Wainer, IW, 2016) | 0.71 |
| " Animal studies have shown that ketamine has neuroprotective properties, and there is no evidence of elevated intracranial pressure after ketamine dosing in humans." | ( Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. Hagelberg, NM; Olkkola, KT; Peltoniemi, MA; Saari, TI, 2016) | 2.16 |
| " In the twice-weekly dosing groups, the mean change in MADRS score at day 15 was -18." | ( A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression. Cooper, K; Daly, EJ; De Boer, P; Drevets, WC; Fava, M; Fedgchin, M; Kurian, B; Lim, P; Manji, H; Murrough, JW; Pinter, C; Sanacora, G; Shelton, RC; Singh, JB; Van Nueten, L; Winokur, A, 2016) | 0.66 |
| "0%) between the 3 dosing groups." | ( Optimal dosing of intravenous ketamine for procedural sedation in children in the ED-a randomized controlled trial. Farooqi, A; Kannikeswaran, N; Lieh-Lai, M; Malian, M; Roback, MG; Wang, B, 2016) | 0.72 |
| " We investigated the efficacy of ketamine in anaesthetic dosage in chronic, refractory CRPS patients that had failed available standard therapies." | ( Results of the Treatment of Chronic, Refractory CRPS with Ketamine Infusions: a Preliminary Report. Puchalski, P; Zyluk, A, 2016) | 0.96 |
| "This study is a 6-week, randomized, double-blind, controlled, parallel-group trial with two intervention arms (ketamine, fixed daily dosage of 150mg vs." | ( Efficacy and safety of oral ketamine versus diclofenac to alleviate mild to moderate depression in chronic pain patients: A double-blind, randomized, controlled trial. Afarideh, M; Agah, E; Akhondzadeh, S; Arbabi, M; Ghajar, A; Jafarinia, M; Noorbala, AA; Saravi, MA; Tafakhori, A, 2016) | 0.94 |
| " To reduce the risk for potential psychodysleptic side effects, however, ketamine dosing tends to be limited to low-dose regimens." | ( The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial. Bornemann-Cimenti, H; Edler, A; Michaeli, K; Sandner-Kiesling, A; Wejbora, M, 2016) | 0.92 |
| " The total dosage of used propofol was also recorded." | ( A comparison between the effects of propofol-fentanyl with propofol-ketamine for sedation in patients undergoing endoscopic retrograde cholangiopancreatography outside the operating room. Akhondzadeh, R; Ghomeishi, A; Nesioonpour, S; Nourizade, S, 2016) | 0.67 |
| "Consenting patients requiring deep sedation were randomized to receive either ketofol or propofol in a double-blind fashion according to a weight-based dosing schedule." | ( Propofol or Ketofol for Procedural Sedation and Analgesia in Emergency Medicine-The POKER Study: A Randomized Double-Blind Clinical Trial. Bell, A; Ding, M; Ferguson, I; Holdgate, A; New, L; Treston, G, 2016) | 0.43 |
| " Information pertaining to pharmacology, pharmacokinetics, dosing regimens, adverse effects, and outcomes was obtained from relevant studies." | ( Ketamine for analgosedation in critically ill patients. Erstad, BL; Patanwala, AE, 2016) | 1.88 |
| " Dosing and monitoring recommendations are provided." | ( Ketamine for analgosedation in critically ill patients. Erstad, BL; Patanwala, AE, 2016) | 1.88 |
| "Prehospital ketamine is associated with a high rate of endotracheal intubation in profoundly agitated patients; however, ketamine dosing is not associated with intubation rate when adjusted for potential confounders." | ( Intubation of Profoundly Agitated Patients Treated with Prehospital Ketamine. Cole, JB; Dodd, KW; Ho, JD; Nystrom, PC; Olives, TD, 2016) | 1.05 |
| " The patient dramatically reduced the dosage of opioid painkillers and ketamine was withdrawn without any withdrawal symptoms." | ( Experience of the use of Ketamine to manage opioid withdrawal in an addicted woman: a case report. Bertschy, G; Lalanne, L; Lang, JP; Nicot, C; Salvat, E, 2016) | 0.97 |
| " No changes in current psychotropic medication or dosage were permitted for 4weeks prior to trial entry and throughout the trial." | ( Increase in PAS-induced neuroplasticity after a treatment course of intranasal ketamine for depression. Report of three cases from a placebo-controlled trial. Alonzo, A; Gálvez, V; Ho, KA; Loo, CK; Nikolin, S; Somogyi, AA, 2017) | 0.68 |
| " 4 mg/kg), total dosage (including top-ups), type and site of procedure, gender and ethnicity were not significant predictors." | ( Predictors of emesis in children undergoing procedural sedation with intramuscular ketamine in a paediatric emergency department. Suryaprakash, S; Tham, LP, 2017) | 0.68 |
| " The present study characterized the dose-response of a subanesthetic IV ketamine bolus (2 and 5mg/kg) and 1-h infusion (5, 10, and 20mg/kg/h) on dissociative stereotypy, locomotion, sensorimotor gating, and thermal nociception in male Sprague-Dawley rats." | ( Dose-response characteristics of intravenous ketamine on dissociative stereotypy, locomotion, sensorimotor gating, and nociception in male Sprague-Dawley rats. Choi, KH; Lee, BH; Moran, S; Osborne, LA; Park, TY; Radford, KD, 2017) | 0.95 |
| " Ketamine (150μg/g), high dose of rhynchophylline (100μg/g) group can significantly reduce the place preference; immunohistochemistry results showed that the number of TH-positive neurons in midbrain was increased in the methamphetamine model group, whereas less TH-positive neurons were found in the ketamine group and high dosage rhynchophylline group." | ( Inhibiting effects of rhynchophylline on methamphetamine-dependent zebrafish are related with the expression of tyrosine hydroxylase (TH). Chen, M; Fang, M; Li, C; Lin, Y; Liu, W; Liu, Y; Luo, C; Mo, Z; Ou, J; Yung, KK; Zhu, C; Zhu, D, 2017) | 1.37 |
| " This adverse effect has not been reported previously at this dosing range." | ( A Case Report: Subanesthetic Ketamine Infusion for Treatment of Cancer-Related Pain Produces Urinary Urge Incontinence. Hunsberger, J; Lee, W; Vickers, BA, 2017) | 0.75 |
| " We hypothesized that low-dose ketamine, compared to placebo, as an adjunctive treatment to opioids would result in better pain control over 2 hours and greater patient satisfaction with pain control; further, this protocol will result in a lower opioid dosage over 2 hours." | ( Ketamine as an Adjunct to Opioids for Acute Pain in the Emergency Department: A Randomized Controlled Trial. Bowers, KJ; Heitz, C; McAllister, KB; Ray, M, 2017) | 2.18 |
| "1 mg/kg ketamine or placebo prior to protocol-based dosing of additional opioid analgesia, if required." | ( Ketamine as an Adjunct to Opioids for Acute Pain in the Emergency Department: A Randomized Controlled Trial. Bowers, KJ; Heitz, C; McAllister, KB; Ray, M, 2017) | 2.33 |
| " jatamansi drug (oral dosage of 500 mg/kg body weight for 14 days) in ketamine-administered male Wistar albino rats (30 mg/kg body weight for 5 days) on modulating behaviour and the level of neurotransmitters like dopamine and glutamate was studied in whole-brain homogenates, and its influence on BDNF and TrkB levels in 2 relevant brain regions, the hippocampus and prefrontal cortex, was assessed." | ( Nardostachys jatamansi Targets BDNF-TrkB to Alleviate Ketamine-Induced Schizophrenia-Like Symptoms in Rats. Janardhanan, A; Sadanand, A; Vanisree, AJ, 2016) | 0.92 |
| " Fundamental questions remain regarding the future prospects of this line of drug development, including questions concerning safety and tolerability, efficacy, dose-response relationships and therapeutic mechanisms." | ( Targeting glutamate signalling in depression: progress and prospects. Abdallah, CG; Mathew, SJ; Murrough, JW, 2017) | 0.46 |
| " Although atipamezole and yohimbine dosing guidelines are available for mice, no controlled comparison has been performed to guide the lab animal community in the selection of one over the other." | ( Comparison of Atipamezole with Yohimbine for Antagonism of Xylazine in Mice Anesthetized with Ketamine and Xylazine. Janssen, CF; Kracinovsky, KB; Maiello, P; Newsome, JT; Wright, MJ, 2017) | 0.67 |
| " Cyclobenzaprine specimens were equally likely to be positive whether the dose was oral or topical, although mean levels after topical dosing were approximately 13-21% those after oral dosing." | ( Urinary Concentrations of Topically Administered Pain Medications. Bell, P; Glinn, MA; Harvey, A; Lickteig, AJ; Rappold, B; Recer, S; Salske, M; Stensland, J; Weber, L, 2017) | 0.46 |
| " Etomidate, mean dosage (SD) = 0." | ( S -ketamine compared to etomidate during electroconvulsive therapy in major depression. Ahrens, K; Dannlowski, U; Dietsche, P; Kircher, T; Kluge, I; Köhnlein, B; Konrad, C; Wohltmann, T; Zavorotnyy, M, 2017) | 1.08 |
| " Patients who do not benefit after the initial dose may benefit with serial dosing or at higher doses." | ( Ketamine for Depression, 1: Clinical Summary of Issues Related to Efficacy, Adverse Effects, and Mechanism of Action. Andrade, C, 2017) | 1.9 |
| "Balanced anesthesia allows for a reduced dosage of each component, while inducing general anesthesia of sufficient depth with potentially fewer side effects." | ( Premedication with fentanyl-midazolam improves sevoflurane anesthesia for surgical intervention in laboratory mice. Arras, M; Cesarovic, N; Jirkof, P; Lipiski, M, 2017) | 0.46 |
| " The data were recorded using a 128-channel electroencephalograph during baseline consciousness, subanesthetic dosing (0." | ( Neurophysiologic Correlates of Ketamine Sedation and Anesthesia: A High-density Electroencephalography Study in Healthy Volunteers. Bel-Bahar, T; Janke, E; Kim, H; Kunkler, BS; Lee, U; Li, D; Mashour, GA; McKinney, AM; Pichurko, AB; Picton, P; Tarnal, V; Vlisides, PE, 2017) | 0.74 |
| "This study investigated the risk factors of ketamine associated-lower urinary tract symptoms (LUTS), such as duration of use, dosage of ketamine, co-occurring substance use of other psychoactive drugs, comorbidities, and depression." | ( Risk Factors of Lower Urinary Tract Syndrome among Ketamine Users. Chen, IC; Chen, WC; Hu, TC; Lee, MH; Lin, HY, 2018) | 0.99 |
| " Duration of use, dosage of ketamine and the OSPI scores were subjected to log transformation because of the skewed distribution." | ( Risk Factors of Lower Urinary Tract Syndrome among Ketamine Users. Chen, IC; Chen, WC; Hu, TC; Lee, MH; Lin, HY, 2018) | 1.03 |
| " When so extended, the ideal frequency is perhaps best individualized wherein ketamine is dosed a little before the effect of the previous session is expected to wear off." | ( Ketamine for Depression, 4: In What Dose, at What Rate, by What Route, for How Long, and at What Frequency? Andrade, C, 2017) | 2.13 |
| " We exposed post-natal day (PND)7 mice to ketamine using a well-established dosing regimen known to induce significant developmental neurotoxicity." | ( Early Exposure to Ketamine Impairs Axonal Pruning in Developing Mouse Hippocampus. Atluri, N; Dalla Massara, L; Jevtovic-Todorovic, V; Katta, G; Obradovic, AL; Oklopcic, A; Osuru, HP; Todorovic, NS, 2018) | 1.08 |
| " Our assumption is that a combination of propofol with esketamine reduces the dosage of individual drugs, thereby minimizing sedation side effects while keeping the same satisfaction level of patients and endoscopists." | ( Sedation with propofol during ERCP: is the combination with esketamine more effective and safer than with alfentanil? Study protocol for a randomized controlled trial. de Jong, E; Eberl, S; Hollmann, MW; Koers, L; Preckel, B; Schneider, T; van Hooft, JE, 2017) | 0.94 |
| " Secondary objectives were to identify the patient population in which ketamine was initiated, assess the proportion of time patients were at their goal level of sedation, and determine the dosing patterns of adjunctive sedative agents." | ( Impact of Ketamine Use on Adjunctive Analgesic and Sedative Medications in Critically Ill Trauma Patients. Chui, SJ; Harbourt, K; Pajoumand, M; Pruskowski, KA; Reynolds, HN, 2017) | 1.09 |
| " The primary objective of this pilot study is to determine if multiple dosing over a three-day perioperative period with oral ketamine is a safe treatment method for acute pain after amputation surgery." | ( Oral Ketamine for Acute Pain Management After Amputation Surgery. Buvanendran, A; Kroin, JS; Moric, M; Rajagopal, A; Robison, SJ; Tuman, KJ, 2018) | 1.2 |
| "Substantial interpatient variability in pharmacokinetics in children complicates the development of adequate dosage regimen for continuous sedation." | ( Pharmacokinetics of S-ketamine during prolonged sedation at the pediatric intensive care unit. Bos, AP; Brouwer, CNM; Flint, RB; Kränzlin, ASC; Lie-A-Huen, L; Mathôt, RAA, 2017) | 0.77 |
| " When a combination failed to meet those criteria in 2 piglets, the next dosage of the DRT was tested." | ( Evaluation of different dose rate combinations of ketamine, romifidine and azaperone for castration of 3-4 and 5-6 weeks old piglets. Bettschart-Wolfensberger, R; Cap, VH; Echtermann, T; Hug, PJ; Janett, F; Nussbaumer, I; Von Ah, S, 2017) | 0.71 |
| " Three studies applied a ketamine protocol to outline dosing and the management of ketamine adverse events." | ( Ketamine for the Acute Management of Excited Delirium and Agitation in the Prehospital Setting. Linder, LM; Ross, CA; Weant, KA, 2018) | 2.23 |
| " Records were also screened for adverse medical events and changes in ketamine dosage over time." | ( Impact of oral ketamine augmentation on hospital admissions in treatment-resistant depression and PTSD: a retrospective study. De Gioannis, A; Garrett-Walcott, S; Hartberg, J, 2018) | 1.07 |
| "To describe the dosing and safety considerations of ketamine for adjunct sedation in a population of mechanically ventilated critically ill patients targeting light sedation." | ( Ketamine Infusion for Adjunct Sedation in Mechanically Ventilated Adults. Bahr, M; Bain, W; Barbash, I; Chin, K; Groetzinger, LM; McVerry, BJ; Rivosecchi, RM, 2018) | 2.17 |
| " La narcose des rennes représente un défi particulier car le dosage sûr et efficace des anesthésiques et trop peu connu." | ( Challenging anaesthetic management of captive reindeer (Rangifer tarandus): Report of 4 cases. Adami, C; McSloy, A; Monticelli, P; Morath, U, 2017) | 0.46 |
| "To assess the efficacy, safety, and dose-response of intranasal esketamine hydrochloride in patients with treatment-resistant depression (TRD)." | ( Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression: A Randomized Clinical Trial. Cooper, K; Daly, EJ; Drevets, WC; Fedgchin, M; Lim, P; Manji, H; Shelton, RC; Singh, JB; Thase, ME; Van Nueten, L; Winokur, A, 2018) | 0.99 |
| " During the open-label phase, dosing frequency was reduced from twice weekly to weekly, and then to every 2 weeks." | ( Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression: A Randomized Clinical Trial. Cooper, K; Daly, EJ; Drevets, WC; Fedgchin, M; Lim, P; Manji, H; Shelton, RC; Singh, JB; Thase, ME; Van Nueten, L; Winokur, A, 2018) | 0.76 |
| "001), with a significant ascending dose-response relationship (P < ." | ( Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression: A Randomized Clinical Trial. Cooper, K; Daly, EJ; Drevets, WC; Fedgchin, M; Lim, P; Manji, H; Shelton, RC; Singh, JB; Thase, ME; Van Nueten, L; Winokur, A, 2018) | 0.76 |
| " Response appeared to persist for more than 2 months with a lower dosing frequency." | ( Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression: A Randomized Clinical Trial. Cooper, K; Daly, EJ; Drevets, WC; Fedgchin, M; Lim, P; Manji, H; Shelton, RC; Singh, JB; Thase, ME; Van Nueten, L; Winokur, A, 2018) | 0.76 |
| " Further research and large clinical trials are needed on the optimum KIT protocol, including dose, dosing interval, total number of treatments and when to stop." | ( Intravenous ketamine infusion for a patient with treatment-resistant major depression: a 10-month follow-up. Hong, JP; Kwon, JH; Lee, JY; Sim, WS; Song, IS, 2018) | 0.86 |
| " We characterized cortical theta-band power and phase-coupling phenotypes, a known neural circuit substrate underlying cognitive functions, and further studied the effects of a subanesthetic dosage of ketamine on theta abnormalities unique to Sp4 hypomorphism." | ( Ketamine independently modulated power and phase-coupling of theta oscillations in Sp4 hypomorphic mice. Behrens, MM; Pinto-Duarte, A; Sejnowski, TJ; Wang, X; Zhou, X, 2018) | 2.11 |
| "Weekly ketamine dosing was safe and well tolerated, and post-dose dissociative symptoms tended to reduce after repeated dosing." | ( Safety and efficacy of maintenance ketamine treatment in patients with treatment-refractory generalised anxiety and social anxiety disorders. Glue, P; Gray, A; Kibby, G; McNaughton, N; Medlicott, NJ; Neehoff, SM, 2018) | 1.21 |
| " It is concluded that there is consistent evidence that a single dose of ketamine has dramatic antisuicidal action that emerges almost immediately after dosing and persists for at least a week." | ( Ketamine for Depression, 6: Effects on Suicidal Ideation and Possible Use as Crisis Intervention in Patients at Suicide Risk. Andrade, C, ) | 1.81 |
| " Continuous intravenous ketamine infusions were the most common route of administration (65%); however, wide variability in dosing and length of therapy was reported." | ( Current Ketamine Practice: Results of the 2016 American Society of Pain Management Nursing Survey on Ketamine. Jungquist, CR; Klaess, CC, 2018) | 1.22 |
| "01 mg/kg) were given at 1-week intervals to each patient, with the midazolam counterbalanced in dosing position across patients." | ( Ketamine Effects on EEG during Therapy of Treatment-Resistant Generalized Anxiety and Social Anxiety. Glue, P; Kawe, T; Martin, D; McNaughton, N; Neehoff, S; Shadli, SM, 2018) | 1.92 |
| " Primary data analyses included dosing and duration of infusion, rates of pre- and post-infusion analgesic administration, and final diagnoses." | ( Continuous Intravenous Sub-Dissociative Dose Ketamine Infusion for Managing Pain in the Emergency Department. Beals, T; Drapkin, J; Fromm, C; Likourezos, A; Marshall, J; Monfort, R; Motov, S, 2018) | 0.74 |
| " Average dosing of SDK infusion was 11." | ( Continuous Intravenous Sub-Dissociative Dose Ketamine Infusion for Managing Pain in the Emergency Department. Beals, T; Drapkin, J; Fromm, C; Likourezos, A; Marshall, J; Monfort, R; Motov, S, 2018) | 0.74 |
| " Dose-response curves for intraperitoneal (ip) copper sulfate and ketamine allowed their combination in equi-effective doses, and their interaction was determined with isobolographic analysis." | ( Antinociception Induced by Copper Salt Revisited: Interaction with Ketamine in Formalin-Induced Intraplantar and Orofacial Pain in Mice. Cazanga, V; Constandil, L; Hernandez, A; Morales, B; Pelissier, T, ) | 0.6 |
| " Outcomes studied included impact on opioid analgesic use, a description of ketamine dosing strategy, and an analysis of adverse events due to opioid or ketamine analgesia." | ( Low-Dose Ketamine Infusion for Adjunct Management during Vaso-occlusive Episodes in Adults with Sickle Cell Disease: A Case Series. Boylan, A; Floroff, C; Hassig, TB; Kanter, J; Palm, N, 2018) | 1.13 |
| " There are converging preclinical and clinical data that isoflurane (and perhaps propofol), dosed to burst suppression, has relatively rapid, robust and durable antidepressant effects and lacks the adverse effects associated with electroconvulsive therapy (ECT)." | ( Emerging evidence for antidepressant actions of anesthetic agents. Mickey, BJ; Tadler, SC, 2018) | 0.48 |
| " Secondary outcomes included cumulative ketamine dose, additional sedative and analgesics used, cumulative sedative and analgesic dosing at all time periods, corticosteroid use, days of mechanical ventilation, ICU LOS, hospital LOS, and mortality." | ( A Non-Comparative Prospective Pilot Study of Ketamine for Sedation in Adult Septic Shock. Boyer, NL; Mount, CA; Reese, JM; Sullivan, VF, 2018) | 1.01 |
| "Consensus guidelines were prepared in the following areas: indications, contraindications for acute pain and whether they differ from those for chronic pain, the evidence for the use of ketamine as an adjunct to opioid-based therapy, the evidence supporting patient-controlled ketamine analgesia, the use of nonparenteral forms of ketamine, and the subanesthetic dosage range and whether the evidence supports those dosages for acute pain." | ( Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Acute Pain Management From the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists. Bhatia, A; Buvanendran, A; Cohen, SP; Davis, FN; Hooten, WM; Hurley, RW; Narouze, S; Schwenk, ES; Viscusi, ER; Wasan, AD, 2018) | 0.93 |
| " Contraindications for acute pain are similar to those for chronic pain, partly based on the observation that the dosage ranges are similar." | ( Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Acute Pain Management From the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists. Bhatia, A; Buvanendran, A; Cohen, SP; Davis, FN; Hooten, WM; Hurley, RW; Narouze, S; Schwenk, ES; Viscusi, ER; Wasan, AD, 2018) | 0.74 |
| "Guidelines were prepared for the following areas: indications; contraindications; whether there was evidence for a dose-response relationship, or a minimum or therapeutic dose range; whether oral ketamine or another N-methyl-D-aspartate receptor antagonist was a reasonable treatment option as a follow-up to infusions; preinfusion testing requirements; settings and personnel necessary to administer and monitor treatment; the use of preemptive and rescue medications to address adverse effects; and what constitutes a positive treatment response." | ( Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Chronic Pain From the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists. Bhatia, A; Buvanendran, A; Cohen, SP; Davis, FN; Hooten, WM; Hurley, RW; Lubenow, TR; Narouze, S; Ritchie, EC; Schwenk, ES; Viscusi, ER; Wasan, AD, 2018) | 0.93 |
| " Subsequently a dosage algorithm for the main trial was developed." | ( [Evaluation of a field-suitable injection anesthesia protocol for the castration of 8 to 14 days old piglets]. Bettschart-Wolfensberger, R; Nussbaumer, I; Rigamonti, S; Schwarz, A, 2018) | 0.48 |
| " Les résultats ont servi de base pour l’algorithme de dosage de l’essai principal." | ( [Evaluation of a field-suitable injection anesthesia protocol for the castration of 8 to 14 days old piglets]. Bettschart-Wolfensberger, R; Nussbaumer, I; Rigamonti, S; Schwarz, A, 2018) | 0.48 |
| "015625 mg/kg/min with dosage reduction -10%/10 min) or saline in a randomized, double-blind, cross-over study." | ( Pharmacological fMRI: Effects of subanesthetic ketamine on resting-state functional connectivity in the default mode network, salience network, dorsal attention network and executive control network. de Boer, P; London, M; Mueller, F; Musso, F; Winterer, G; Zacharias, N, 2018) | 0.74 |
| " Additionally, evidence suggested a dose-response relationship; future studies are needed to optimize dose." | ( Intravenous Ketamine for Adolescents with Treatment-Resistant Depression: An Open-Label Study. Albott, CS; Amatya, P; Carstedt, P; Cullen, KR; Eberly, LE; Gunlicks-Stoessel, M; Horek, N; Klimes-Dougan, B; Lim, KO; Reigstad, K; Ren, Y; Roback, MG; Samikoglu, A; Tye, S; Westlund Schreiner, M, 2018) | 0.86 |
| "This study demonstrates a lower intubation rate in patients administered ketamine than prior literature in association with a lower weight-based dosing regimen." | ( Outcomes of Prehospital Chemical Sedation With Ketamine Versus Haloperidol and Benzodiazepine or Physical Restraint Only. Castellana, A; Gross, K; O'Connor, L; O'Connor, MJ; Rebesco, M; Restuccia, M; Robinson, C, ) | 0.62 |
| "5 K: the standard dosage of ketamine (0." | ( [Evaluation of Anesthesia Method to Minimize Intraoperative Body Movement and Respiratory Depression for Dilatation and Curettage A Retrospective Study]. Kitamura, J; Yamaguchi, S, 2016) | 0.73 |
| " To optimize low-dose ketamine as an acute migraine treatment, future studies should investigate more effective dosing and routes of administration." | ( Low-dose Ketamine Does Not Improve Migraine in the Emergency Department: A Randomized Placebo-controlled Trial. Bos, L; Etchison, AR; Heitz, C; McAllister, KB; Mohammed, M; Park, B; Phan, AV; Ray, M, 2018) | 1.21 |
| "The male street KAs caught by policemen and patients visiting urologic clinics were invited to answer a structured questionnaire including demographic data, illicit drug use related details (duration, frequency, dosage and abstinence status), international prostate symptoms score (IPSS), interstitial cystitis symptoms and problem index (ICSI and ICPI) and International index of erectile function (IIEF-5)." | ( Sexual and bladder dysfunction in male ketamine abusers: A large-scale questionnaire study. Chang, SJ; Chen, WS; Chen, YC; Hsu, WT; Jang, MY; Lee, KH; Yang, SS, 2018) | 0.75 |
| " Sedative medication dosing and observed adverse events were similar to those reported previously in children without ASD." | ( Procedural sedation in children with autism spectrum disorders in the emergency department. Brown, JJ; Farooqi, A; Gray, JM; Kannikeswaran, N; Roback, MG; Sethuraman, U, 2019) | 0.51 |
| " Dosage of each anesthetic agent was tailored to yield unresponsiveness (Ramsay score = 6)." | ( The spectral exponent of the resting EEG indexes the presence of consciousness during unresponsiveness induced by propofol, xenon, and ketamine. Boly, M; Boveroux, P; Brichant, JF; Casarotto, S; Chieregato, A; Colombo, MA; Gosseries, O; Laureys, S; Massimini, M; Napolitani, M; Rex, S; Rosanova, M; Sarasso, S, 2019) | 0.72 |
| " The site-based MADRS interviews were recorded at the baseline and 2 h post-dose assessments on the first intranasal dosing day." | ( Comparability of blinded remote and site-based assessments of response to adjunctive esketamine or placebo nasal spray in patients with treatment resistant depression. Cooper, K; Daly, E; Fedgchin, M; Singh, JB; Targum, SD, 2019) | 0.74 |
| " As these new indications continue to come to light, it is important to stay current with the dosing for these indications as well as the adverse effects associated with ketamine's use." | ( Subdissociative Ketamine Use in the Emergency Department. Nichols, KA; Paciullo, CA, ) | 0.67 |
| " This study sought to investigate the impact of adjunctive continuous infusion ketamine on concomitant analgesic and sedative dosing while providing goal comfort in mechanically ventilated patients." | ( Continuous Infusion Ketamine for Adjunctive Analgosedation in Mechanically Ventilated, Critically Ill Patients. Carter, KE; Droege, CA; Garber, PM; Harger, NJ; Mueller, EW, 2019) | 1.06 |
| " Exploratory evaluation of independent factors associated with ketamine responders (50% or more relative reduction in analgesic-sedative dosing requirements at 24 hrs) and nonresponders (less than 50% relative reduction) was performed using multivariate logistic regression." | ( Continuous Infusion Ketamine for Adjunctive Analgosedation in Mechanically Ventilated, Critically Ill Patients. Carter, KE; Droege, CA; Garber, PM; Harger, NJ; Mueller, EW, 2019) | 1.08 |
| "For severe cancer-related pain that is not relieved adequately by escalating doses of oral or parenterally administered strong opioid analgesics such as morphine, alone or in combination with an adjuvant drug such as ketamine, more invasive dosing routes may be warranted." | ( Bioerodable Ketamine-Loaded Microparticles Fabricated Using Dissolvable Hydrogel Template Technology. Han, FY; Smith, MT; Whittaker, AK; Zhu, M, 2019) | 1.08 |
| "Although few studies have used ketamine for induction and maintenance of pediatric anesthesia, official dosage recommendations are lacking." | ( Assessment of Ketamine Adult Anesthetic Doses in Pediatrics Using Pharmacokinetic Modeling and Simulations. Alruwaili, N; Drover, DR; Elkomy, MH; Elmowafy, M; Ramamoorthy, C; Shalaby, K, 2019) | 1.16 |
| "Weight-based dosing minimizes age-dependent variation in the plasma concentration of ketamine." | ( Assessment of Ketamine Adult Anesthetic Doses in Pediatrics Using Pharmacokinetic Modeling and Simulations. Alruwaili, N; Drover, DR; Elkomy, MH; Elmowafy, M; Ramamoorthy, C; Shalaby, K, 2019) | 1.1 |
| " To investigate whether ketamine at subanesthetic dosage or its environmental condition can cause long-term cognitive dysfunction after multiple exposures in male or female neonatal rats, postnatal day 5 (P5)-day-old Sprague-Dawley rats were randomized into three groups: ketamine group, vehicle group, and control group (no disturbance)." | ( Neonatal exposure to the experimental environment or ketamine can induce long-term learning dysfunction or overmyelination in female but not male rats. Chen, B; Deng, X; Liu, H; Wang, B; Zhang, J, 2019) | 1.07 |
| "25 to 7 mg/kg and from 50 mg per occasion to 300 mg per occasion in multiple daily dosing, daily dosing, and intermittent dosing schedules." | ( Oral Ketamine for Depression, 1: Pharmacologic Considerations and Clinical Evidence. Andrade, C, 2019) | 1.03 |
| " In case reports, case series, standard operating practice in ketamine facilities, and randomized controlled trials, oral ketamine has been administered through weight-based dosing and as fixed doses, and the dosing strategy has been one-size-fits-all or individualized through a dose discovery process." | ( Oral Ketamine for Depression, 2: Practical Considerations. Andrade, C, 2019) | 1.27 |
| " At the upper end of the dosing range, it displays dissociative anesthetic and amnestic effects, while at lower doses, it acts as an analgesic and demonstrates opioid-sparing capabilities." | ( The Use of Ketamine for the Management of Acute Pain in the Emergency Department. Davis, KA; Davis, WD; Hooper, K, ) | 0.52 |
| "Evidence suggests that IV ketamine provides significant short-term analgesic benefit in patients with refractory chronic pain, with some evidence of a dose-response relationship." | ( Ketamine Infusions for Chronic Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Bhatia, A; Cohen, SP; Orhurhu, MS; Orhurhu, V, 2019) | 2.26 |
| " The purpose of this study is to determine the efficacy of subanesthetic dosing of ketamine during TKA on postoperative pain and narcotic consumption." | ( Intraoperative Ketamine in Total Knee Arthroplasty Does Not Decrease Pain and Narcotic Consumption: A Prospective Randomized Controlled Trial. Emper, WD; Freedman, KB; Good, RP; Levicoff, EA; Longenecker, AS; McComb, JJ; Rhee, JH; Shaner, JL; Tan, TL, 2019) | 1.09 |
| " This study compared the efficacy and safety of switching patients with treatment-resistant depression from an ineffective antidepressant to flexibly dosed esketamine nasal spray plus a newly initiated antidepressant or to a newly initiated antidepressant (active comparator) plus placebo nasal spray." | ( Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study. Bajbouj, M; Cooper, K; Daly, EJ; Drevets, WC; Hough, D; Lane, R; Lim, P; Manji, H; Mazzucco, C; Molero, P; Popova, V; Shelton, RC; Singh, JB; Thase, ME; Trivedi, M; Vieta, E, 2019) | 0.98 |
| " We previously reported that TAK-137, an AMPA-R potentiator with little agonistic effect, had potent procognitive effects with lower risks of bell-shaped dose-response and seizure induction." | ( TAK-137, an AMPA receptor potentiator with little agonistic effect, produces antidepressant-like effect without causing psychotomimetic effects in rats. Hara, H; Kimura, H; Kunugi, A; Murakami, K; Suzuki, A; Tajima, Y, 2019) | 0.51 |
| " Several administrations routes, dosing schemas and esketamine are investigated in basic and clinical research with particular focus on treatment-resistant depression (TRD) where drug demonstrates its efficacy where very limited alternatives are available." | ( Short-term ketamine administration in treatment-resistant depression: focus on cardiovascular safety. Cubała, WJ; Szarmach, J; Wiglusz, MS; Włodarczyk, A, 2019) | 1.15 |
| "Changes in EEG slow wave activity after a hypnotic dose of ketamine could be fitted by a standard sigmoid dose-response model." | ( Electroencephalographic slow wave dynamics and loss of behavioural responsiveness induced by ketamine in human volunteers. Pullon, RM; Sleigh, J; Vlisides, PE; Warnaby, CE, 2019) | 0.98 |
| "Time to relapse after successful treatment with a single infusion of ketamine appears to follow a dose-response relationship, where higher dosage leads to increased time to relapse." | ( Time to relapse after a single administration of intravenous ketamine augmentation in unipolar treatment-resistant depression. Cusin, C; Debattista, C; Fava, M; Flynn, M; Freeman, MP; Hock, RS; Hoeppner, B; Ionescu, DF; Iosifescu, DV; Mathew, SJ; Papakostas, GI; Salloum, NC; Sanacora, G; Trivedi, MH, 2020) | 1.03 |
| " A dose-response profile was noted for anxiolytic effects, dissociative side effects, and changes in blood pressure and heart rate after ketamine dosing." | ( Effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders: Exploratory double-blind psychoactive-controlled replication study. Broughton, L; Glue, P; Le Nedelec, M; McNaughton, N; Medlicott, NJ; Neehoff, S; Sabadel, A; Shadli, S, 2020) | 1.15 |
| " Optimal dosing schedules to best prolong the antidepressant effects of ketamine have yet to be determined." | ( Ketamine and Treatment-Resistant Depression. Arredondo, A; Austin, PN; Lent, JK; Pugh, MA, 2019) | 2.19 |
| " Anesthesiologists should consider the dosage and timing of intravenous ketamine administration during MEP monitoring." | ( A Bolus Dose of Ketamine Reduces the Amplitude of the Transcranial Electrical Motor-evoked Potential: A Randomized, Double-blinded, Placebo-controlled Study. Baba, H; Deguchi, H; Furutani, K; Kamiya, Y; Matsuhashi, M; Mitsuma, Y, 2021) | 1.2 |
| "This phase 3 double-blind study randomized patients with treatment-resistant depression (TRD) ≥65 years (1:1) to flexibly dosed esketamine nasal spray and new oral antidepressant (esketamine/antidepressant) or new oral antidepressant and placebo nasal spray (antidepressant/placebo)." | ( Efficacy and Safety of Esketamine Nasal Spray Plus an Oral Antidepressant in Elderly Patients With Treatment-Resistant Depression-TRANSFORM-3. Adler, C; Daly, EJ; Drevets, WC; Gaillard, R; Hough, D; Lane, R; Lim, P; Manji, H; McShane, R; Morrison, RL; Ochs-Ross, R; Sanacora, G; Singh, JB; Steffens, DC; Wilkinson, ST; Zhang, Y, 2020) | 1.07 |
| " Future studies and best practice techniques can facilitate standardization of regional anesthesia adjuvant dosing when providing nerve blocks in clinical practice." | ( Adjuvants in clinical regional anesthesia practice: A comprehensive review. Cornett, EM; Gaignard, SM; Kaye, AD; Kaye, RJ; Lambert, T; Moll, V; Prabhakar, A; Ragusa, J; Urman, RD; Wheat, S, 2019) | 0.51 |
| " Kinetic analyses of MLK infusions in cattle are necessary to establish optimal dosing protocols." | ( Pharmacokinetics of an intravenous constant rate infusion of a morphine-lidocaine-ketamine combination in Holstein calves undergoing umbilical herniorrhaphy. Coetzee, JF; Hartnack, AK; Kleinhenz, MD; Lakritz, J; Niehaus, AJ, 2020) | 0.78 |
| " Kinetic analyses of MLK infusions in cattle are necessary to establish optimal dosing protocols and withdrawal intervals." | ( Analgesic efficacy of an intravenous constant rate infusion of a morphine-lidocaine-ketamine combination in Holstein calves undergoing umbilical herniorrhaphy. Coetzee, JF; Hartnack, AK; Kleinhenz, MD; Lakritz, J; Niehaus, AJ, 2020) | 0.78 |
| " BP increases reached the maximum postdose value within ~ 40 min of esketamine dosing and returned to the predose range by ~ 1." | ( Cardiac Safety of Esketamine Nasal Spray in Treatment-Resistant Depression: Results from the Clinical Development Program. Doherty, T; Melkote, R; Miller, J; Singh, JB; Wajs, E; Weber, MA, 2020) | 1.12 |
| "BP elevations following esketamine dosing are generally transient, asymptomatic, and not associated with serious cardiovascular safety sequalae." | ( Cardiac Safety of Esketamine Nasal Spray in Treatment-Resistant Depression: Results from the Clinical Development Program. Doherty, T; Melkote, R; Miller, J; Singh, JB; Wajs, E; Weber, MA, 2020) | 1.18 |
| " Dosage of ketamine was too low to reduce the severity of PPSP." | ( Effects of Intraoperative Low-Dose Ketamine on Persistent Postsurgical Pain after Breast Cancer Surgery: A Prospective, Randomized, Controlled, Double-Blind Study. Baik, JS; Cho, AR; Kang, C; Kim, C; Kim, E; Kim, H; Kim, KH; Kwon, JY; Lee, EA; Lee, HJ, 2020) | 1.22 |
| "Rats treated with the highest tested dosage (20 mg/kg) of ketamine had lower weight gain in the 1st and 2nd weeks of treatment and all experimental groups had measurable alterations in the serotoninergic system." | ( Preclinical toxicological study of prolonged exposure to ketamine as an antidepressant. de Abreu, GR; Fukushima, AR; Manes, M; Moreira, N; Ricci, EL; Spinosa, HS; Waziry, PAF; Zaccarelli-Magalhães, J, 2020) | 1.05 |
| " We excluded studies with bipolar depression or with repeated dosing and no single-dose phase." | ( The relationship between subjective effects induced by a single dose of ketamine and treatment response in patients with major depressive disorder: A systematic review. Kosten, TR; Mathai, DS; Meyer, MJ; Storch, EA, 2020) | 0.79 |
| " We hypothesized that oral controlled-release ketamine tablets would improve safety and tolerability compared with injected ketamine by reducing peak ketamine exposures compared with dosing by injection." | ( Ascending-Dose Study of Controlled-Release Ketamine Tablets in Healthy Volunteers: Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability. Glue, P; Hung, CT; Hung, N; Lam, F; Medlicott, NJ; Surman, P, 2020) | 1.08 |
| " However, IV administration is associated with a number of drawbacks and advanced delivery platforms could provide an alternative parenteral route of esketamine dosing in patients." | ( Hydrogel-forming microneedle arrays as a therapeutic option for transdermal esketamine delivery. Courtenay, AJ; Donnelly, RF; Kearney, MC; Levin, G; Levy-Nissenbaum, E; McAlister, E; McCarthy, HO; McCrudden, MTC; Shterman, N; Steiner, L; Vora, L, 2020) | 0.98 |
| "This study aimed to develop a method that objectively measures the clinical benefits of ketamine infusions to treat complex regional pain syndrome (CRPS), thus making it possible, for the first time, to determine the optimal dosing of ketamine and duration of treatment to treat CRPS." | ( Optimizing the Treatment of CRPS With Ketamine. Alexander, J; Bavry, E; Kirkpatrick, AF; Qiu, P; Saghafi, A; Schwartzman, R; Yang, K, 2020) | 1.05 |
| "20 (depending on the dosing regimen used); p ≤ 0." | ( Efficacy of single and repeated administration of ketamine in unipolar and bipolar depression: a meta-analysis of randomized clinical trials. Brzostek, T; Kawalec, P; Kryst, J; Lasoń, W; Mitoraj, AM; Pilc, A, 2020) | 0.81 |
| " Most TEAEs occurred on dosing days, were mild or moderate in severity, and resolved on the same day." | ( Esketamine Nasal Spray Plus Oral Antidepressant in Patients With Treatment-Resistant Depression: Assessment of Long-Term Safety in a Phase 3, Open-Label Study (SUSTAIN-2). Aluisio, L; Daly, EJ; Drevets, WC; George, JE; Grunfeld, J; Holder, R; Hough, D; Jeon, HJ; Kasper, S; Lane, R; Li, CT; Lim, P; Manji, H; Morrison, RL; Paik, JW; Sanacora, G; Singh, JB; Sulaiman, AH; Wajs, E; Wilkinson, ST; Young, AH, 2020) | 1.28 |
| " In females, ethanol-induced CPP was generally less robust compared to males, but ketamine pretreatment resulted in a rightward shift in the dose-response curve, given that ketamine pretreated rats needed a higher dose of ethanol compared to saline pretreated rats to exhibit ethanol-induced CPP." | ( Early-life ketamine exposure attenuates the preference for ethanol in adolescent Sprague-Dawley rats. Blevins, KM; Franco, D; Iñiguez, SD; Núñez-Larios, EA; Ricoy, UM; Zamudio, J; Zavala, AR, 2020) | 1.17 |
| " Dosing recommendations however are often based on strategies used in patients with normal body habitus." | ( Drug dosing in the critically ill obese patient-a focus on sedation, analgesia, and delirium. Barletta, JF; Erstad, BL, 2020) | 0.56 |
| " Interestingly, the dosage in both conditions is similar, and positive symptoms of schizophrenia appear before antidepressant effects emerge." | ( Brain NMDA Receptors in Schizophrenia and Depression. Adell, A, 2020) | 0.56 |
| " Increasing knowledge on the mechanism of ketamine should drive future studies on the optimal balance of dosing ketamine for maximum antidepressant efficacy with minimum exposure." | ( A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression. Albott, CS; Erbes, C; Lim, KO; Shiroma, PR; Thuras, P; Tye, S; Wels, J, 2020) | 1.03 |
| "This study aimed to estimate the cost-effectiveness of esketamine, a novel intranasally dosed antidepressant, for patients in the United States with treatment-resistant depression." | ( Cost-Effectiveness of Esketamine Nasal Spray for Patients With Treatment-Resistant Depression in the United States. Ross, EL; Soeteman, DI, 2020) | 1.11 |
| " esketamine is cheap, requires less frequent dosing (once a week), and is a simpler procedure compared to intravenous infusions, it might have an impact on public health." | ( Effects of subcutaneous esketamine on blood pressure and heart rate in treatment-resistant depression. Abdo, G; Barbosa, M; Cohrs, FM; de Jesus Mari, J; Del Porto, JA; Del Sant, LC; Delfino, R; Fava, VAR; Lacerda, ALT; Liberatori, A; Lucchese, AC; Magalhães, EJM; Nakahira, C; Sarin, LM; Steiglich, MS; Surjan, J; Tuena, MA, 2020) | 1.48 |
| " Older age, hypertension, large ketamine dosage and dissociative symptoms may predict increased ketamine-induced cardiovascular effects." | ( Cardiovascular effects of repeated subanaesthetic ketamine infusion in depression. Lan, XF; Liu, WJ; Ning, YP; Wang, CY; Weng, SY; Zheng, W; Zhou, YL, 2021) | 1.16 |
| " A total of 24 patients received short-term ascending subcutaneous doses of ketamine and were then eligible to enter a 3-month maintenance phase of 1 mg/kg ketamine dosed once or twice weekly." | ( Anxiolytic effects of acute and maintenance ketamine, as assessed by the Fear Questionnaire subscales and the Spielberger State Anxiety Rating Scale. Glue, P; Gray, A; Neehoff, S; Nehoff, H; Truppman Lattie, D, 2021) | 1.11 |
| "Acute ketamine dosing showed a rapid dose-related reduction in all three FQ subscales (agoraphobia, social phobia and blood-injury phobia) and in the SSAI." | ( Anxiolytic effects of acute and maintenance ketamine, as assessed by the Fear Questionnaire subscales and the Spielberger State Anxiety Rating Scale. Glue, P; Gray, A; Neehoff, S; Nehoff, H; Truppman Lattie, D, 2021) | 1.36 |
| "The present study characterized the effects of weekly ketamine injections on sexual behavior and anxiety in female and male rats, using a dosing protocol that mimics human therapeutic treatment for depression." | ( I. Antidepressants and sexual behavior: Weekly ketamine injections increase sexual behavior initially in female and male rats. Ali, M; Clemons, LW; Davis, LK; Gonzalez, CMF; Guarraci, FA; Henneman, EL; Lucero, D; Meerts, SH; Odell, SE, 2020) | 1.06 |
| "This narrative review describes pharmacological properties, dosing strategies, adminis-tration considerations, and adverse effects of ketamine." | ( Ketamine for Acute Pain Management and Sedation. Brown, K; Tucker, C, 2020) | 2.2 |
| " Further larger sample studies are needed to confirm these preliminary findings, analyzing differential response/remission rates by affective disorder, optimal dosing strategies, and its long-term effects." | ( An Update on the Efficacy and Tolerability of Oral Ketamine for Major Depression: A Systematic Review and Meta-Analysis. Frye, MA; Joseph, B; Kung, S; Nuñez, NA; Pahwa, M; Prokop, LJ; Schak, KM; Seshadri, A; Singh, B; Vande Voort, JL, 2020) | 0.81 |
| " Medications used, adverse events and the need for repeat dosing were abstracted from prehospital care reports." | ( Description of Adverse Events in a Cohort of Dance Festival Attendees with Stimulant-Induced Severe Agitation Treated with Dissociative-Dose Ketamine. Drapkin, J; Friedman, MS; Haaland, A; Likourezos, A; Saloum, D; Strayer, RJ, ) | 0.33 |
| " Notably, the dosage of ketamine for antidepressive action is comparable to the dose that can generate schizophrenia-like psychotic symptoms." | ( Candidate Strategies for Development of a Rapid-Acting Antidepressant Class That Does Not Result in Neuropsychiatric Adverse Effects: Prevention of Ketamine-Induced Neuropsychiatric Adverse Reactions. Fukuyama, K; Kawano, Y; Motomura, E; Okada, M; Shiroyama, T, 2020) | 1.06 |
| " The design then uses Bayesian dose-response modelling to undertake a comparative effectiveness analysis for the most successful dose combination against a relevant comparator." | ( A Bayesian response-adaptive dose-finding and comparative effectiveness trial. Heath, A; Klassen, TP; Offringa, M; Pechlivanoglou, P; Poonai, N; Pullenayegum, E; Rios, D; Yaskina, M, 2021) | 0.62 |
| " Thus, we evaluated the significance of dosing interval in the neurotoxic effects of multiple ketamine injections in postnatal day (PND) 17 mice." | ( Interval-dependent neurotoxicity after multiple ketamine injections in late postnatal mice. Chung, W; Cui, J; Heo, JY; Hong, B; Ju, X; Kim, YH; Ko, Y; Lee, Y; Youn, AM; Yun, S, 2021) | 1.1 |
| " Future studies should carefully consider the dosing interval as a significant factor when studying the neurotoxic effects of multiple anesthetic exposures." | ( Interval-dependent neurotoxicity after multiple ketamine injections in late postnatal mice. Chung, W; Cui, J; Heo, JY; Hong, B; Ju, X; Kim, YH; Ko, Y; Lee, Y; Youn, AM; Yun, S, 2021) | 0.88 |
| " Logistic regression will be used to model the dose-response relationship for the combinations of intranasal Ketodex." | ( Adaptive randomised controlled non-inferiority multicentre trial (the Ketodex Trial) on intranasal dexmedetomidine plus ketamine for procedural sedation in children: study protocol. Ali, S; Beer, D; Bhatt, M; Coriolano, K; Doan, Q; Heath, A; Hickes, S; Kam, A; Klassen, T; Offringa, M; Pechlivanoglou, P; Poonai, N; Sabhaney, V; Sawyer, S; Yaskina, M, 2020) | 0.77 |
| "Ketamine for rapid sequence intubation (RSI) is typically dosed at 1 to 2 mg/kg intravenously." | ( Prehospital Ketamine Use for Rapid Sequence Intubation: Are Higher Doses Associated With Adverse Events? Brenna, CC; Buderer, N; Fulton, S; Hutchison, H; Jackson, J; Krebs, W; Paplaskas, AM; Rodgers, M; Stausmire, J; Swecker, KA; Werman, H, ) | 1.95 |
| " Because of the lack of efficacy of drugs available for pain, ketamine and magnesium in combination provide a novel therapeutic approach that needs to be standardized with a suitable dosing regimen, including the chronological order of drug administration." | ( Interactions between Ketamine and Magnesium for the Treatment of Pain: Current State of the Art. Divac, N; Medić, B; Prostran, M; Srebro, D; Stojanović, R; Vučković, S; Vujović, A; Vujović, KS, 2021) | 1.18 |
| " Despite its ubiquitous use as a postoperative analgesic, no studies have described dosing differences between opioid-tolerant (OT) and nonopioid-tolerant (NOT) patients or determined optimal dosing." | ( Examining Use of Low-Dose Ketamine Infusions During the Postoperative Period: A Retrospective Study Comparing Opioid-Tolerant and Nonopioid-Tolerant Patients. Cianci, MJ; Hebl, JR; Martin, EE; Mauck, WD; Ochs Kinney, MA, 2021) | 0.92 |
| " We compared locomotor behaviors; dose-response curves for tricaine, ketamine, and 2,6-diisopropylphenol (propofol); time to emergence from these anesthetics; and time to emergence from propofol after craniotomy in glyt1-/- mutants and their siblings." | ( Elevated preoptic brain activity in zebrafish glial glycine transporter mutants is linked to lethargy-like behaviors and delayed emergence from anesthesia. Bindernagel, R; Buglo, E; Dallman, JE; Engert, F; Kelz, MB; Meng, QC; Randlett, O; Sloan, SA; Stark, MJ; Sumathipala, SH; Syed, S; Venincasa, MJ; Yan, Q; Züchner, S, 2021) | 0.86 |
| " However, current evidence can be used when developing dosing strategies, preparing for adverse reactions, and generating hypotheses for future, more robust research." | ( Intranasal Ketamine for Acute Pain. Rocchio, RJ; Ward, KE, 2021) | 1.01 |
| " Further study is required to confirm the finding that mean propofol dosing was higher in the ketamine group, and to investigate the implication that this dose of ketamine may have affected the WAVCNS." | ( The Effect of Low-Dose Intraoperative Ketamine on Closed-Loop-Controlled General Anesthesia: A Randomized Controlled Equivalence Trial. Ansermino, JM; Cooke, E; Dumont, GA; Görges, M; Merchant, RN; Napoleone, G; van Heusden, K; West, N, 2021) | 1.11 |
| " Although additional research is needed to ascertain optimal dosing schedules and route of Ketamine, given these promising findings, Ketamine may be a useful option for improving the treatment of refractory pain in patients with cancer and a good tool in palliative medicine for treating neoplastic pain." | ( Low-dose ketamine as an adjuvant for pain control in a cancer patient: a case report. Fattakhov, E; Galea, J; Kaur, G; Patel, S; Singh, AB; Tatachar, V, 2021) | 1.26 |
| " In addition, ketamine seems to be most successful when administered consistently throughout a procedure, such as by an infusion instead of a single bolus, in order to have adequate dosing for an analgesic effect." | ( Ketamine Use in the Surgical Patient: a Literature Review. Moon, TS; Smith, KM, 2021) | 2.42 |
| "1 mg · kg-1 · h-1 for next 48 h [both medications dosed at ideal body weight]; methadone/ketamine group)." | ( Perioperative Methadone and Ketamine for Postoperative Pain Control in Spinal Surgical Patients: A Randomized, Double-blind, Placebo-controlled Trial. Avram, MJ; Benson, J; Bilimoria, S; Greenberg, SB; Maher, CE; Murphy, GS; Szokol, JW; Teister, K, 2021) | 1.14 |
| " It is not clear if the results from that research can be extrapolated to systems that use different dosing regimens for ketamine RSI." | ( The association of ketamine induction with blood pressure changes in paramedic rapid sequence intubation of out-of-hospital traumatic brain injury. Bernard, S; Fouche, PF; Jennings, PA; Meadley, B; Smith, K; St Clair, T; Winnall, A, 2021) | 1.16 |
| " Prospective studies are needed to determine which dosing strategy would be the most beneficial for hospice patients." | ( Single Subcutaneous Ketamine Dose Followed by Oral Ketamine for Depression Symptoms in Hospice Patients: A Case Series. Grant, PC; Hansen, E; Kerr, CW; Latuga, NM; Levy, K; Luczkiewicz, DL, 2021) | 0.94 |
| " Ketamine dosing was studied up to 20 mg/kg intravenously for the single-dose neuropathology study and up to 60 mg/kg intraperitoneally for the multiple-dose neuropathology study." | ( A comparison of the pharmacokinetics and NMDAR antagonism-associated neurotoxicity of ketamine, (2R,6R)-hydroxynorketamine and MK-801. Burke, RD; Elayan, I; Gould, TD; Lemke-Boutcher, LE; Lynch, DC; Mathew, S; Moaddel, R; Morris, PJ; Rao, DB; Sharma, AK; Thomas, CJ; Zanos, P; Zarate, CA, ) | 1.26 |
| " Despite wide variability in proposed dosing and method of administration when used for analgesia, it is important all clinicians be familiar with the pharmacodynamics of ketamine in order to appropriately anticipate its therapeutic and adverse effects." | ( Ketamine for Pain Management: A Review of Literature and Clinical Application. Caruso, K; Lyden, A; Tyler, D, ) | 1.77 |
| "The anesthetic ketamine after intravenous dosing is nearly completely metabolized to R- and S-stereoisomers of the active norketamine (analgesic, psychoactive) and 2,6-hydroxynorketamine (potential analgesic, antidepressant) as well as the inactive dehydronorketamine." | ( Chiral Pharmacokinetics and Metabolite Profile of Prolonged-release Ketamine Tablets in Healthy Human Subjects. Adler, S; Dokter, A; Grube, M; Hasan, M; Link, A; Meissner, K; Modess, C; Rey, H; Roustom, T; Siegmund, W, 2021) | 1.21 |
| "Prolonged-release ketamine tablets generate a high systemic exposure to 2,6-hydroxynorketamines and might therefore be an efficient and safer pharmaceutical dosage form for treatment of patients with chronic neuropathic pain compared to intravenous infusion." | ( Chiral Pharmacokinetics and Metabolite Profile of Prolonged-release Ketamine Tablets in Healthy Human Subjects. Adler, S; Dokter, A; Grube, M; Hasan, M; Link, A; Meissner, K; Modess, C; Rey, H; Roustom, T; Siegmund, W, 2021) | 1.19 |
| "Prolonged-release ketamine tablets generate a high systemic exposure to 2,6-hydroxynorketamines and might therefore be an efficient and safer pharmaceutical dosage form for treatment of patients with chronic neuropathic pain compared to intravenous infusion." | ( Chiral Pharmacokinetics and Metabolite Profile of Prolonged-release Ketamine Tablets in Healthy Human Subjects. Adler, S; Dokter, A; Grube, M; Hasan, M; Link, A; Meissner, K; Modess, C; Rey, H; Roustom, T; Siegmund, W, 2021) | 1.19 |
| " There was no association with either the dosage or duration of treatment and frequency of side-effects." | ( Long-term safety and efficacy of sublingual ketamine troches/lozenges in chronic non-malignant pain management. Aggarwal, A; Gibson, SB; Maudlin, B, 2022) | 0.98 |
| " Results were compared with serious adverse events (SAEs) in patients treated with ketamine according to three systematic reviews considering dosing regimen and cumulative dose." | ( Harm related to recreational ketamine use and its relevance for the clinical use of ketamine. A systematic review and comparison study. Van Amsterdam, J; Van Den Brink, W, 2022) | 1.24 |
| "We aimed to assess and compare the analgesic efficacies and adverse effects of ketamine administered through a breath-actuated nebulizer at 3 different dosing regimens for emergency department patients presenting with acute and chronic painful conditions." | ( Comparison of Nebulized Ketamine at Three Different Dosing Regimens for Treating Painful Conditions in the Emergency Department: A Prospective, Randomized, Double-Blind Clinical Trial. Butt, M; Davis, A; Dove, D; Drapkin, J; Fassassi, C; Favale, P; Gohel, A; Hossain, R; Kabariti, S; Likourezos, A; Marshall, J; Motov, S; Silver, M, 2021) | 1.16 |
| "Intranasal drug delivery offers a non-invasive and convenient dosing option for patients and physicians, especially for conditions requiring chronic/repeated-treatment administration." | ( Effect of Esketamine Nasal Spray on Olfactory Function and Nasal Tolerability in Patients with Treatment-Resistant Depression: Results from Four Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Studies. Cooper, K; Daly, E; Doty, RL; Drevets, WC; Fedgchin, M; Jamieson, C; Janik, A; Lane, R; Lim, P; Melkote, R; Ochs-Ross, R; Popova, V; Singh, J; Wylie, C, 2021) | 1 |
| "Most trials of adding lithium involved older, mainly tricyclic, antidepressants, and the dosing of adjunctive treatments were not optimized." | ( Efficacy and Tolerability of Combination Treatments for Major Depression: Antidepressants plus Second-Generation Antipsychotics vs. Esketamine vs. Lithium. Bahji, A; Baldessarini, RJ; Tondo, L; Undurraga, J; Vázquez, GH, 2021) | 0.82 |
| " The dose-response relationship calls for caution with higher doses of tranylcypromine." | ( Cardiovascular Effects of Combining Subcutaneous or Intravenous Esketamine and the MAO Inhibitor Tranylcypromine for the Treatment of Depression: A Retrospective Cohort Study. Bauer, M; Findeis, H; Ludwig, VM; Ritter, P; Rucker, J; Sauer, C; Young, AH, 2021) | 0.86 |
| " Our ketamine dose-titration method is detailed allowing flexible dosing of patients across a treatment course enabling individualised treatment." | ( Ketamine treatment for depression: A model of care. Alonzo, A; Bayes, A; Dong, V; Kabourakis, M; Loo, C; Martin, D, 2021) | 2.58 |
| " In the patient domain, we identify a variety of standard operating procedures involving initial patient assessment parameters, ketamine dosing and administration guidelines, and safety monitoring procedures." | ( Developing an IV Ketamine Clinic for Treatment-Resistant Depression: a Primer. Achtyes, E; Bobo, WV; Coryell, W; Drake, K; Frye, MA; Goddard, A; Goes, F; Greden, JF; Kaplin, A; Lopez, D; Maixner, D; Parikh, SV; Rico, J; Riva-Posse, P; Singh, B; Tarnal, V; Vande Voort, JL; Watson, B, 2021) | 1.17 |
| "The results of this Dutch nationwide survey study show that there are heterogeneous treatment protocols with different indications, treatment setting and dosing regimen for the treatment of chronic pain with ketamine." | ( Ketamine therapy for chronic pain in The Netherlands: a nationwide survey. Bharwani, KD; Dirckx, M; Huygen, FJPM; Mangnus, TJP; Stronks, DL, 2022) | 2.35 |
| "Management of refractory pain in pediatric sickle cell disease (SCD) and oncology is reliant on opioids though high opioid dosing increases side effects and tachyphylaxis." | ( Low-dose Ketamine Infusion for Pediatric Hematology/Oncology Patients: Case Series and Literature Review. Agrawal, AK; Chen, A; Chen, E; Long, LS; Yu, H, 2022) | 1.14 |
| " Further research is warranted into: optimal dosing strategy, including number and frequency; and long-term efficacy and safety." | ( The rapid anti-suicidal ideation effect of ketamine: A systematic review. Grunebaum, MF; Hochschild, A; Mann, JJ, 2021) | 0.88 |
| " We sought to measure the frequency of ED intubation at a Midwest academic medical center after prehospital ketamine use for profound agitation, hypothesizing that intubation has become less frequent as prehospital ketamine has become more common and prehospital dosing has improved." | ( Outcomes Associated with Lower Doses of Ketamine by Emergency Medical Services for Profound Agitation. Ahmed, A; Coffey, SK; Egan, H; Harland, KK; Mohr, NM; Vakkalanka, JP; Wallace, K, 2021) | 1.1 |
| " Our findings also provide additional support for the importance of dosing frequency in establishing the cognitive effects of repeated ketamine exposure." | ( (R,S)-ketamine and (2R,6R)-hydroxynorketamine differentially affect memory as a function of dosing frequency. An, X; Gould, TD; Pereira, EFR; Riggs, LM, 2021) | 1.31 |
| " Sedative depth, a composite score comprised of five assessment criteria, was observed every 5-min from dosing until arousal." | ( Differential effects of four intramuscular sedatives on cardiorespiratory stability in juvenile guinea pigs (Cavia porcellus). Berry, MJ; Dyson, RM; Gray, CL; Pacharinsak, C; Sixtus, RP, 2021) | 0.62 |
| "9% saline (placebo) in combination with ketamine and rocuronium, according to a weight-based dosing schedule." | ( Fentanyl versus placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department: The FAKT study-A randomized clinical trial. Aneman, A; Burns, B; Buttfield, A; Ferguson, I; Harris, IA; Milligan, J; Reid, C; Shepherd, S, 2022) | 1.28 |
| " Findings may guide clinicians in consideration and dosing of ketamine for multimodal analgosedation." | ( Impact of Ketamine on Analgosedative Consumption in Critically Ill Patients: A Systematic Review and Meta-Analysis. Burry, LD; Chan, K; De Castro, C; Tse, C; Williamson, DR; Wunsch, H, 2022) | 1.36 |
| " intranasal ketamine, ideal target populations, and optimal dosing to treat both depression and pain." | ( Ketamine as a therapeutic agent for depression and pain: mechanisms and evidence. Haroutounian, S; Lenze, EJ; Palanca, BJA; Subramanian, S, 2022) | 2.54 |
| "All subjects had advanced cancer, with intractable pain, despite being on moderate dosage of opioids." | ( A dose-escalation clinical trial of intranasal ketamine for uncontrolled cancer-related pain. Beumer, JH; Curseen, K; Egan, K; Gillespie, TW; Harvey, RD; Lane, O; Shteamer, JW; Singh, V; Sniecinski, R; Spektor, B; Switchenko, J; Tsvetkova, M; Zarrabi, AJ, 2022) | 0.98 |
| " We provide the evidence supporting recent developments using esketamine as well as unresolved issues in the field, such as dosing and safety." | ( Ketamine for treatment of mood disorders and suicidality: A narrative review of recent progress. Kritzer, MD; Lai, CS; Masand, PS; Mathew, SJ; Mischel, NA; Szabo, ST; Young, JR, 2022) | 2.4 |
| " Secondary outcomes included a comparison of sedative dosing pre- and post-ketamine initiation between place in therapy groups and paralyzed/nonparalyzed patients, and identification of ketamine-attributed adverse drug event (ADEs) or iatrogenic withdrawal syndrome (IWS)." | ( Ketamine infusions as an adjunct for sedation in critically ill children. Johnson, PN; Mayes, R; Miller, JL; Moore, E; Neely, S; Nguyen, AL, ) | 1.8 |
| " However, it is worth noting that the variability in the ketamine dose-response curve across cats and cortices was larger than that in the sleep-stage data, highlighting the differential local dynamics created by two different ways of modulating conscious state." | ( Ketamine and sleep modulate neural complexity dynamics in cats. Bekinschtein, TA; Bor, D; Canales-Johnson, A; Castro-Zaballa, S; Mediano, PAM; Pascovich, C; Torterolo, P, 2022) | 2.41 |
| "To determine the effective dosage of the combination tiletamine-zolazepam-ketamine-xylazine (TKX), with or without methadone, in dogs." | ( Determination of the effective dosage of tiletamine-zolazepam-ketamine-xylazine, with or without methadone, in dogs. Baier, ME; Herrera Becerra, JR; Martins, LGB; Monteiro, ER; Souza, MJ, 2022) | 1.19 |
| " The current study investigated 1) changes in neurocognitive performance after a repeated ketamine dosing regimen and 2) baseline neurocognitive performance as a predictor of ketamine treatment effect." | ( Neurocognitive effects of repeated ketamine infusions in comorbid posttraumatic stress disorder and major depressive disorder. Albott, CS; Erbes, C; Lim, KO; Shiroma, PR; Thuras, P; Tye, SJ; Wels, J, 2022) | 1.22 |
| " Since then, intravenous ketamine and intranasal S-ketamine have been validated for the treatment of depression and suicidal ideation following dose-response and double-blind placebo-controlled clinical trials." | ( Key considerations for the use of ketamine and esketamine for the treatment of depression: focusing on administration, safety, and tolerability. Kritzer, MD; Masand, PS; Pae, CU, 2022) | 1.3 |
| "We recommend further investigation into treatment dosing and frequency strategies as well as approaches that prolong the therapeutic effects." | ( Key considerations for the use of ketamine and esketamine for the treatment of depression: focusing on administration, safety, and tolerability. Kritzer, MD; Masand, PS; Pae, CU, 2022) | 1 |
| "Subanesthetic dosing of intravenous ketamine has shown to be an effective treatment for patients with major depressive disorder." | ( Vital Sign Changes During Intravenous Ketamine Infusions for Depression: An Exploratory Study of Prognostic Indications. Arfken, C; Froehlich, A; Geller, J; Keith, KM; Mischel, N; Oxley, M, ) | 0.68 |
| " Dosage of propofol required in group E (1." | ( The effectiveness of esketamine and propofol versus dezocine and propofol sedation during gastroscopy: A randomized controlled study. Chen, L; Tang, T; Xu, Y; Zhang, Y; Zhang, Z; Zheng, Y, 2022) | 1.03 |
| " It is unknown whether repeat sub-anesthetic dosing of ketamine in adults with TRD is associated with Olney lesions or other neuropathologies." | ( A review of potential neuropathological changes associated with ketamine. Ho, R; Lui, LMW; McIntyre, RS; Nazal, H; Nogo, D; Rosenblat, JD; Song, Y; Teopiz, KM, 2022) | 1.21 |
| " Therefore, the objective of this study was to investigate a potential dose-response relationship between ketamine and bilirubin levels." | ( Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome. Andermatt, R; Bartussek, J; Buehler, PK; Camen, G; David, S; Erlebach, R; Hofmaenner, DA; Jüngst, C; Müllhaupt, B; Schuepbach, RA; Wendel-Garcia, PD, 2022) | 1.34 |
| " Recommended changes to dosing strategies of medications such as ketamine." | ( Analgesia and Sedation for Tactical Combat Casualty Care: TCCC Proposed Change 21-02. April, MD; Blackman, V; Brown, J; Butler, FK; Cunningham, CW; DesRosiers, TT; Drew, B; Fisher, AD; Gurney, JM; Holcomb, JB; Montgomery, HR; Morgan, MM; Motov, SM; Papalski, W; Remley, MA; Schauer, SG; Shackelford, SA; Sprunger, T, 2022) | 0.96 |
| " Further studies with a larger sample size are needed to assess the ap-propriate dosing strategy for ketamine to produce adequate analgesia when used as a primary analgesic in mechanically ventilated patients." | ( Impact of ketamine versus fentanyl continuous infusion on opioid use in patients admitted to a surgical-trauma intensive care unit. Kataria, V; Mooney, J; Nguyen, HL; Pazhani, Y; Ramos, A; Roth, J, ) | 0.75 |
| " We developed a clinical treatment protocol for the use of repeated SC racemic ketamine (maximum six treatments, twice per week) in an inpatient psychiatric care setting with inclusion/exclusion criteria, dosing schedule, and description of treatment, assessment, and monitoring procedures." | ( Repeated subcutaneous racemic ketamine in treatment-resistant depression: case series. Budd, GP; Do, A; Fridfinnson, J; Lam, RW; Rafizadeh, R; Siu, JTP; Tham, JCW, 2022) | 1.24 |
| " Here, we present dosage regimens of ketamine/xylazine/atropine in 10-day-old C57BL/6J mouse pups that allow endotracheal intubation, while minimizing animal mortality." | ( Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery. Feneley, MP; Graham, RM; Iismaa, SE; Nicks, AM; Skowno, JJ; Wu, J, 2022) | 0.99 |
| " The consistency of respiratory parameters during the entire exposure time is paramount to ensuring dosing accuracy." | ( Comparison of Alfaxalone-Midazolam, Tiletamine-Zolazepam, and KetamineAcepromazine Anesthesia during Plethysmography in Cynomolgus Macaques ( Astleford, SM; Bowling, PA; Casselman, AM; Dixon, BC; Ghering, JM; Marion, BM; White, CE, 2022) | 0.96 |
| " Therefore, taking a look at individual patient risks and potential underlying variability in pharmacokinetics may improve safety and dosing of these new antidepressant drugs in clinical practice." | ( Pharmacogenetic and drug interaction aspects on ketamine safety in its use as antidepressant - implications for precision dosing in a global perspective. Just, KS; Langmia, IM; Müller, JP; Stingl, JC; Yamoune, S, 2022) | 0.98 |
| " Further research is warranted to better define doses and dosing paradigms that are beneficial without unintended side effects in adolescence." | ( Neurobiological, behavioral, and cognitive effects of ketamine in adolescents: A review of human and pre-clinical research. Acevedo, J; Siegel, JA, 2022) | 0.97 |
| " The secondary outcomes included injection pain score, vital signs, total dosage of vasoactive drugs used within 5 minutes after induction, and adverse events related to drugs." | ( Pretreatment with Low-Dose Esketamine for Reduction of Propofol Injection Pain: A Randomized Controlled Trial. Fu, D; Han, Y; Jia, J; Li, W; Wang, D, 2022) | 1.01 |
| " Studies have shown that the application of propofol combined with ketamine in painless gastrointestinal endoscopy is beneficial to reduce the dosage of propofol and the incidence of related complications." | ( Efficacy and safety of subanesthetic doses of esketamine combined with propofol in painless gastrointestinal endoscopy: a prospective, double-blind, randomized controlled trial. Li, J; Li, S; Li, Y; Liang, S; Liang, Z; Luo, Q; Yang, Z; Zhan, Y, 2022) | 1.21 |
| " We found a large heterogeneity regarding sample size, age and gender distribution, inclusion criteria (different severity scores, if any) and ketamine dosing (bolus and/or continuous infusion)." | ( Use of ketamine in patients with refractory severe asthma exacerbations: systematic review of prospective studies. Astuto, M; Brancati, S; Crimi, C; Cuttone, G; Dezio, V; Falcone, M; La Via, L; Sanfilippo, F, 2022) | 1.38 |
| "The present study aimed to find the optimal dosage of K-X and its association with the changes in dendritic spine number of the CA1 region for aged and young rats of both sexes." | ( Optimisation of ketamine-xylazine anaesthetic dose and its association with changes in the dendritic spine of CA1 hippocampus in the young and old male and female Wistar rats. Namavar, MR; Sotoudeh, N, 2022) | 1.07 |
| " Future studies should investigate the appropriate dosage and route of administration of ketamine to be used while managing pain among children with acute and severe pain in the emergency department." | ( The Effectiveness of Ketamine Compared to Opioid Analgesics for management of acute pain in Children in The Emergency Department: systematic Review. Alanazi, E, 2022) | 1.26 |
| " However, almost all known AMPA-R potentiators carry the risk of a narrow bell-shaped dose-response curve and a poor safety margin against seizures." | ( Role of the AMPA receptor in antidepressant effects of ketamine and potential of AMPA receptor potentiators as a novel antidepressant. Hara, H; Kimura, H; Suzuki, A, 2023) | 1.16 |
| " This validated method was applicable to determine the stereoselective pharmacokinetic profiles of (R,S)-Ket, (R,S)-NK, and (2R,6R;2S,6S)-HNK in plasma and brain collected from individual mice after a single intraperitoneal dosing of racemic Ket at an antidepressant dose." | ( Chiral LC-MS/MS method for the simultaneous determination of (R,S)-ketamine, (R,S)-norketamine, and (2R,6R;2S,6S)-hydroxynorketamine in mouse plasma and brain. Endo, H; Mizuno-Yasuhira, A; Toki, H; Yamaguchi, JI, 2023) | 1.15 |
| " One significant change is the drug dosage regimen; 1 μg/kg fentanyl, 2 mg/kg ketamine, and 2 mg/kg rocuronium is recommended as the main drug dosing regimen for both medical and trauma patients." | ( The Prehospital Emergency Anaesthetic in 2022. Broomhead, R; Dawson, J; Morton, S; Sherren, P; Wareham, G, ) | 0.36 |
| " These findings justify further study into the optimal dosing of fentanyl during RSI in pre-hospital and retrieval medicine." | ( The effect of ketamine and fentanyl on haemodynamics during intubation in pre-hospital and retrieval medicine. Aneman, A; Bliss, J; Ferguson, IMC; Harris, IA; Miller, MR; Partyka, C, 2023) | 1.27 |
| " Compared with the control group, the total dosage of propofol in the experimental group was significantly lower, and the number of vasoactive drugs, the incidence of respiratory depression and bronchospasm were significantly lower (P < ." | ( Low dose of esketamine combined with propofol in painless fibronchoscopy in elderly patients. Chen, Z; Du, T; Feng, Y; Wang, J, 2022) | 1.08 |
| "In vivo plasma concentration data were obtained from 15 healthy volunteers after intravenous and oral dosing of 20 mg PR-ketamine tablets." | ( Relationship Between Dissolution Rate in Vitro and Absorption Rate in Vivo of Ketamine Prolonged-Release Tablets. Weiss, M, 2023) | 1.35 |
| " At the first change the xylazine dosage was the same for surgery, and sequentially the dosage could be reduced (0." | ( [Sole abscess (Pododermatitis purulenta superficialis) in a Bactrian camel - diagnosis, treatment, and healing process]. Eibl, C; Kofler, J; Schoiswohl, J, 2023) | 0.91 |
| " The optimal dosage of this treatment would have to be determined as well as a maintenance of efficacy scheme." | ( Effect of a single dose of intravenous ketamine on the wish to hasten death in palliative care: A case report in advanced cancer. Clatot, F; Decazes, E; Rigal, O, 2023) | 1.18 |
| "In this RCT, the primary objective is to demonstrate that an intermittent esketamine dosing regimen is non-inferior to a continuous esketamine dosing regimen at 3 months follow-up." | ( Intermittent versus continuous esketamine infusions for long-term pain modulation in complex regional pain syndrome: protocol of a randomized controlled non-inferiority study (KetCRPS-2). Baart, SJ; Bharwani, KD; de Vos, CC; Dik, WA; Dirckx, M; Huygen, FJPM; Mangnus, TJP; Redekop, K; Siepman, TAM, 2023) | 1.42 |
| " However, due to its side effects, such as addiction and cognitive impairment, the dosage and frequency of (S)-ketamine approved by the FDA for the treatment of refractory depression is very low, which limits its efficacy." | ( A Multifunctional Nanocarrier System for Highly Efficient and Targeted Delivery of Ketamine to NMDAR Sites for Improved Treatment of Depression. Gao, Q; Ge, J; Li, R; Song, H; Tan, R; Wan, Y; Wang, S; Xu, P; Zhou, L, 2023) | 1.35 |
| " However, the proper dosage for intranasal use in children with congenital heart disease (CHD) has not been determined." | ( Median effective dose of esketamine for intranasal premedication in children with congenital heart disease. Bai, J; Gu, H; Huang, J; Liu, D, 2023) | 1.21 |
| " Additional prospective studies are needed to determine optimal induction agent selection and dosing in patients presenting with shock or sepsis." | ( Pharmacotherapy optimization for rapid sequence intubation in the emergency department. Brown, CS; Engstrom, K; Lyons, N; Mattson, AE; Rech, MA, 2023) | 0.91 |
| " However, a wealth of paediatric safety and dosing data exists for ketamine, given its extensive use globally as an anaesthetic, analgesic and sedative agent." | ( The safety of repeated ketamine dosing in paediatrics: A systematic review. James, IG; James, L; Wakefield, J, 2023) | 1.46 |
| "To evaluate the safety of repeat dosing of ketamine in children." | ( The safety of repeated ketamine dosing in paediatrics: A systematic review. James, IG; James, L; Wakefield, J, 2023) | 1.48 |
| " The objective of this systematic review is to identify and present studies comparing low-dose ketamine to opioids when combined with propofol for procedural sedation in the ED and to describe the dosing regimen, observed efficacy, and side effects." | ( Low-dose ketamine or opioids combined with propofol for procedural sedation in the emergency department: a systematic review. De Vries, LJ; Lameijer, H; Van Roon, EN; Veeger, NJGM, 2023) | 1.55 |
| " For propofol dosage, the administration of esketamine required a lower propofol dosage compared to the NS group and opioids group]." | ( Efficacy and safety of esketamine for sedation among patients undergoing gastrointestinal endoscopy: a systematic review and meta-analysis. Guo, Y; Jing, Y; Lian, X; Lin, Y; Luo, T; Yuan, H, 2023) | 1.47 |
| " Variation exists in the recommended agent and dosing strategies." | ( Evaluation of Nonintubated Analgesia Practices in Critical Care Transport. Bondurant, M; Esteves, AM; Gilchrist, HE; Markwood, JM; Roginski, MA, ) | 0.13 |
| " Consistent pulmonary delivery is critical for experimental power and reproducibility, but we observed variation in outcomes between handlers using different anesthetic approaches for intranasal dosing in mice." | ( Optimizing anesthesia and delivery approaches for dosing into lungs of mice. Cleary, SJ; Conrad, C; Looney, MR; Magnen, M; Moussavi-Harami, SF; Qiu, L; Seo, Y, 2023) | 0.91 |
| "The optimal dosage and method of esketamine for postpartum depressive symptoms (PDS) are unclear." | ( Effects of different doses of esketamine intervention on postpartum depressive symptoms in cesarean section women: A randomized, double-blind, controlled clinical study. Bai, ZH; Chen, L; Duan, KM; Gao, K; Li, QW; Mao, XY; Ping, AQ; Wang, SY; Xu, SY; Yang, SQ; Yang, ST; Zhou, YY, 2023) | 1.47 |
| "Subanaesthetic dosing of ketamine reduced correlates of predictive coding but did not eliminate them." | ( Subanaesthetic doses of ketamine reduce but do not eliminate predictive coding responses: implications for mechanisms of sensory disconnection. Banks, MI; Casey, C; Filbey, W; Mohanta, S; Pearce, RA; Saalmann, Y; Sanders, RD; Tanabe, S; Weber, L; Wehrman, JJ, 2023) | 1.52 |
| "The aim of this study is to assess the current situation in out of hospital pain management in Germany regarding the substances, indications, dosage and the delegation of the use of analgesics to emergency medical service (EMS) staff." | ( Application of analgesics in emergency services in Germany: a survey of the medical directors. Scharonow, M; Scharonow, O; Vilcane, S; Weilbach, C, 2023) | 0.91 |
| " However, previous reports have been essentially based on ketamine dosing modes that differ from the clinical route of administration (slow intravenous infusion)." | ( Temporal dynamics of BDNF signaling recruitment in the rat prefrontal cortex and hippocampus following a single infusion of a translational dose of ketamine. Caffino, L; Chiamulera, C; Fumagalli, F; Mottarlini, F; Piva, A; Rizzi, B, 2024) | 1.89 |
| "Ketamine produces rapid antidepressant effects at sub-anesthetic dosage through early and sustained activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), however, the exact molecular mechanism still remains unclear." | ( Enhanced TARP-γ8-PSD-95 coupling in excitatory neurons contributes to the rapid antidepressant-like action of ketamine in male mice. Chen, JG; Chen, MM; He, JG; Lu, LL; Song, SJ; Wang, F; Xue, SG, 2023) | 2.56 |
| Role | Description |
|---|---|
| intravenous anaesthetic | null |
| NMDA receptor antagonist | Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs. |
| analgesic | An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| neurotoxin | A poison that interferes with the functions of the nervous system. |
| environmental contaminant | Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| xenobiotic | A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| cyclohexanones | Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof. |
| secondary amino compound | A compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups. |
| monochlorobenzenes | Any member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Pathway | Proteins | Compounds |
|---|---|---|
| Vitamin D-sensitive calcium signaling in depression | 2 | 13 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.0112 | 0.0032 | 45.4673 | 12,589.2998 | AID2517 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 17.9008 | 0.0123 | 7.9835 | 43.2770 | AID1346984 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 14.1254 | 0.0054 | 28.0263 | 1,258.9301 | AID1346985 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 79.4328 | 0.0060 | 26.1688 | 89.1251 | AID540317 |
| geminin | Homo sapiens (human) | Potency | 4.1095 | 0.0046 | 11.3741 | 33.4983 | AID624296 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 35.4813 | 0.8913 | 12.0676 | 28.1838 | AID1487 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 125.8920 | 6.3096 | 60.2008 | 112.2020 | AID720707 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID480455 | Inhibition of dexamethasone-induced human NR1-1a/NR2B receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L13-E6 cells assessed as LDH release after 30 mins | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. |
| AID1079941 | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | |||
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | |||
| AID625285 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID28681 | Partition coefficient (logD6.5) | 2000 | Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13 | QSAR model for drug human oral bioavailability. |
| AID1692779 | Drug elimination in human urine assessed as metabolically unchanged compound | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID27167 | Delta logD (logD6.5 - logD7.4) | 2000 | Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13 | QSAR model for drug human oral bioavailability. |
| AID679762 | TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation (Calcein-AM: ? uM, Ketamine: 100 uM) in MDR1-expressing MDCKII cells | 2002 | The Journal of pharmacology and experimental therapeutics, Dec, Volume: 303, Issue:3 | Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. |
| AID765751 | Analgesic effect in iv dosed Sprague-Dawley rat assessed as time required to cause pedal withdrawal reflex | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17 | Structure-activity relationships for ketamine esters as short-acting anaesthetics. |
| AID1525556 | Inhibition of human TASK3 expressed in Xenopus oocytes at 100 uM by whole cell patch clamp assay relative to control | 2019 | Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22 | TASK Channels Pharmacology: New Challenges in Drug Design. |
| AID1692785 | Displacement of [3H]-MK801 from NMDA receptor in rat brain membranes incubated for 45 mins in presence of Mg2+ by scintillation counting method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1692773 | Bioavailability in SL dosed human | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1692775 | Displacement of [3H]-MK801 from NMDA receptor in Sprague-Dawley rat cerebral cortex by liquid scintillation counting method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID765752 | Anesthetic effect in iv dosed Sprague-Dawley rat assessed as dose required to cause loss of righting reflex | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17 | Structure-activity relationships for ketamine esters as short-acting anaesthetics. |
| AID496820 | Antimicrobial activity against Trypanosoma brucei | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID1692765 | Aqueous solubility of the compound | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID496819 | Antimicrobial activity against Plasmodium falciparum | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID146726 | Inhibition of sodium channels through tonic blockade | 2003 | Journal of medicinal chemistry, Jun-05, Volume: 46, Issue:12 | Design, synthesis, and evaluation of analogues of 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide as orally available general anesthetics. |
| AID223455 | Evaluated in vivo for its NMDA antagonist activity by the inhibition of NMDA-induced lethality in mice | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Synthesis and pharmacological evaluation of 4a-phenanthrenamine derivatives acting at the phencyclidine binding site of the N-methyl-D-aspartate receptor complex. |
| AID588212 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID625287 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1692778 | Drug elimination in human urine assessed as formation of dehydronorketamine | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID496825 | Antimicrobial activity against Leishmania mexicana | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID144606 | Inhibition of [3H]MK-801 binding to N-methyl-D-aspartate glutamate receptor of rat cerebral cortical synaptic membrane | 1998 | Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18 | Synthesis and biological activity of conformationally restricted analogues of milnacipran: (1S, 2R)-1-phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide is a novel class of NMDA receptor channel blocker. |
| AID765748 | Anesthetic effect in iv dosed Sprague-Dawley rat assessed as time required to walk | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17 | Structure-activity relationships for ketamine esters as short-acting anaesthetics. |
| AID144832 | Binding affinity towards PCP site of the NMDA receptor was measured by displacement of [3H]TPC in whole rat brain homogenate | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Synthesis and pharmacological evaluation of 4a-phenanthrenamine derivatives acting at the phencyclidine binding site of the N-methyl-D-aspartate receptor complex. |
| AID625292 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1692792 | Displacement of [3H]-MK801 from NMDA receptor in dog cerebral cortex incubated for 45 mins by liquid scintillation spectrometry | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID625288 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | |||
| AID625282 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID590109 | Inhibition of human recombinant NR1/NR2A receptor expressed in U2OS assessed as change in intracellular calcium level by FLIPR assay | 2011 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 21, Issue:7 | Novel analogues of ketamine and phencyclidine as NMDA receptor antagonists. |
| AID590108 | Inhibition of human recombinant NR1/NR2B receptor expressed in U2OS assessed as change in intracellular calcium level by FLIPR assay | 2011 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 21, Issue:7 | Novel analogues of ketamine and phencyclidine as NMDA receptor antagonists. |
| AID540211 | Fraction unbound in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID1692796 | Displacement of [3H]-MK801 from rat brain GluN1/GluN2A expressed in HEK293 cells | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID681116 | TP_TRANSPORTER: transepithelial transport (basal to apical) in MDR1-expressing MDCKII cells | 2002 | The Journal of pharmacology and experimental therapeutics, Dec, Volume: 303, Issue:3 | Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. |
| AID1692790 | Displacement of [3H]-MK801 from NMDA receptor in Dunkin-Hartley guinea pig brain homogenate incubated for 45 mins by liquid scintillation spectrometry | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1692761 | Displacement of [3H]-MK801 from NMDA receptor in rat brain membranes incubated for 60 mins in presence of Mg2+ by liquid scintillation counting method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID625280 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1692805 | Anesthetic activity in IN dosed human assessed as time duration for onset of action | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1602887 | Short-acting anaesthetic activity in Sprague-Dawley rat assessed as time for return of righting reflex after infusion stopped at 20 mg/kg/min followed by dose reduction to 6.7 mg/kg/min dosed via infusion | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Ketamine esters and amides as short-acting anaesthetics: Structure-activity relationships for the side-chain. |
| AID1692786 | Displacement of [3H]-TCP from NMDA receptor in rat brain membranes incubated for 45 mins in presence of Mg2+ by scintillation counting method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1692759 | Antagonist activity at NMDA receptor (unknown origin) assessed as trapping capability relative to control | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1583472 | Induction of dendritogenesis in Sprague-Dawley rat cortical neurons assessed as increase in dendritic arbor complex at 1 nM after 1 hr supplemented with fresh neurobasal medium measured after 71 hrs by Alexa Fluor 488 dye based imaging analysis | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3 | Identification of Psychoplastogenic |
| AID1692803 | Anesthetic activity in IM dosed human assessed as time duration for onset of action | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1474166 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID1602883 | Displacement of [3H] MK-801 from NMDA glutamate ion channel in Wistar rat brain membranes (minus cerebellum) after 3 hrs by scintillation counting analysis | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Ketamine esters and amides as short-acting anaesthetics: Structure-activity relationships for the side-chain. |
| AID29359 | Ionization constant (pKa) | 2000 | Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13 | QSAR model for drug human oral bioavailability. |
| AID1473738 | Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID496832 | Antimicrobial activity against Trypanosoma brucei rhodesiense | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID1692770 | Protein binding in human plasma | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | |||
| AID146725 | Inhibition of sodium channels through phasic blockade | 2003 | Journal of medicinal chemistry, Jun-05, Volume: 46, Issue:12 | Design, synthesis, and evaluation of analogues of 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide as orally available general anesthetics. |
| AID1692758 | Displacement of [3H]-MK801 from NMDA receptor in rat whole brain homogenate incubated for 2 hrs in presence of Mg2+ by liquid scintillation counting method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID540213 | Half life in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID496826 | Antimicrobial activity against Entamoeba histolytica | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID1692788 | Displacement of [3H]-MK801 from NMDA receptor in rat brain membranes incubated for 2 hrs in presence of Mg2+/glumate/glycine by radioligand binding assay | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1473741 | Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID480448 | Inhibition of electric eel AChE by modified Ellman's method | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. |
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | |||
| AID204690 | Compound tested for inhibition uptake of Serotonin transporter with cerebral cortical synaptic membrane of rats using [3H]paroxetine; not tested | 1998 | Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18 | Synthesis and biological activity of conformationally restricted analogues of milnacipran: (1S, 2R)-1-phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide is a novel class of NMDA receptor channel blocker. |
| AID1443980 | Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate transport preincubated for 10 mins prior to ATP addition measured after 15 mins in presence of [3H]-tauroch | 2010 | Toxicological sciences : an official journal of the Society of Toxicology, Dec, Volume: 118, Issue:2 | Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. |
| AID144466 | Inhibition of [3H]-MK-801 binding to NMDA receptor from rat cerebral cortical synaptic membrane | 1996 | Journal of medicinal chemistry, Nov-22, Volume: 39, Issue:24 | Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxami de, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist. |
| AID496824 | Antimicrobial activity against Toxoplasma gondii | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID1692806 | Anesthetic activity in po dosed human assessed as time duration for onset of action | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID625291 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1473740 | Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 10 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID29811 | Oral bioavailability in human | 2000 | Journal of medicinal chemistry, Jun-29, Volume: 43, Issue:13 | QSAR model for drug human oral bioavailability. |
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | |||
| AID1909434 | Inhibition of eGFP-tagged rat GluN1-1a/GluN2A transfected in human tsA201 cells assessed as inhibition glutamate-induced current measured at -65 mV holding potential applied for 10 secs by whole-cell patch-clamp method | 2022 | European journal of medicinal chemistry, Jun-05, Volume: 236 | Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease. |
| AID1692764 | Dissociation constant, pKa of compound | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID588211 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID625278 | FDA Liver Toxicity Knowledge Base Benchmark Dataset (LTKB-BD) drugs of no concern for DILI | 2011 | Drug discovery today, Aug, Volume: 16, Issue:15-16 | FDA-approved drug labeling for the study of drug-induced liver injury. |
| AID1473739 | Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | |||
| AID1602886 | Analgesic activity in Sprague-Dawley rat assessed as minimal dose for loss of pedal withdrawal reflex at 20 mg/kg/min followed by dose reduction to 6.7 mg/kg/min dosed via infusion | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Ketamine esters and amides as short-acting anaesthetics: Structure-activity relationships for the side-chain. |
| AID480463 | Cytotoxicity against mouse L12-G10 cells by MTT assay | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. |
| AID765749 | Anesthetic effect in iv dosed Sprague-Dawley rat assessed as duration of recovery of righting reflex | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17 | Structure-activity relationships for ketamine esters as short-acting anaesthetics. |
| AID411793 | Metabolic stability in human liver microsomes assessed as intrinsic clearance per mg of protein | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Metabolic soft spot identification and compound optimization in early discovery phases using MetaSite and LC-MS/MS validation. |
| AID1692797 | Displacement of [3H]-MK801 from rat brain GluN1/GluN2B expressed in HEK293 cells | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | |||
| AID1692794 | Displacement of [3H]-MK801 from NMDA receptor in Sprague-Dawley rat cerebellum by liquid scintillation counting method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | |||
| AID1692802 | Displacement of [3H]-MK801 from NMDA receptor in rat forebrain homogenate incubated for 2 hrs in presence of Mg2+ by liquid scintillation counting method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID480452 | Inhibition of equine serum BChE at 10 uM by modified Ellman's method | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. |
| AID1692767 | Bioavailability in human at 0.5 mg/kg, IM | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1692777 | Drug elimination in human urine assessed as formation of norketamine | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1692808 | Anesthetic activity in po dosed human assessed as time duration of action | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1124803 | Antagonist activity at NR1/NR2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at pH 7.6 at -40mV holding potential by two-electrode voltage-clamp electrophysiology | 2014 | Bioorganic & medicinal chemistry, Apr-01, Volume: 22, Issue:7 | Some non-conventional biomolecular targets for diamidines. A short survey. |
| AID625286 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1692768 | Oral bioavailability in human | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1909463 | Inhibition of human GluN1/N2A expressed in HEK293 cells assessed as NMDA/glycine-induced fraction of total transmembrane voltage field at 10 uM preincubated for 20 secs followed by NMDA treatment for 10 secs by patch-clamp method | 2022 | European journal of medicinal chemistry, Jun-05, Volume: 236 | Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease. |
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | |||
| AID496829 | Antimicrobial activity against Leishmania infantum | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID496827 | Antimicrobial activity against Leishmania amazonensis | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID110161 | Ability to cause loss of righting reflex in mice represented as no. of counts for each animal for a total of 90 min when 100 mg/kg dose was administered intraperitoneally | 1985 | Journal of medicinal chemistry, Sep, Volume: 28, Issue:9 | Aminotetralone analogues of ketamine: synthesis and evaluation of hypnotic and locomotor properties in mice. |
| AID1602885 | Short-acting anaesthetic activity in Sprague-Dawley rat assessed as dose causing loss of righting reflex at 20 mg/kg/min followed by dose reduction to 6.7 mg/kg/min dosed via infusion | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Ketamine esters and amides as short-acting anaesthetics: Structure-activity relationships for the side-chain. |
| AID765750 | Analgesic effect in iv dosed Sprague-Dawley rat assessed as dose required to cause pedal withdrawal reflex | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17 | Structure-activity relationships for ketamine esters as short-acting anaesthetics. |
| AID21247 | Partition coefficient was expressed as the ratio of the equilibrium concentration in chloroform solvent to that in an equal volume of pH 7.4 aqueous buffer | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. |
| AID496821 | Antimicrobial activity against Leishmania | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID1692793 | Displacement of [3H]-MK801 from NMDA receptor in rat spinal cord incubated for 45 mins by liquid scintillation spectrometry | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID625279 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID625281 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1692774 | Cmax in human at 2 mg/kg, iv measured after 1 mins | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID21246 | Partition coefficient was expressed as the ratio of the equilibrium concentration in benzene solvent to that in an equal volume of pH 7.4 aqueous buffer | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. |
| AID1692804 | Anesthetic activity in SC dosed human assessed as time duration for onset of action | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1474167 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID496828 | Antimicrobial activity against Leishmania donovani | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID1702354 | Antidepressant-like activity in Wistar rat assessed as minimum effective dose causing reduction in immobility time administered intraperitoneally with compound 60 mins prior to testing and measured for 5 mins test period by Porsolt-forced swim test | |||
| AID765747 | Dissociation constant, pKa of the compound | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17 | Structure-activity relationships for ketamine esters as short-acting anaesthetics. |
| AID1079939 | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | |||
| AID1692798 | Displacement of [3H]-MK801 from NMDA receptor in rat striatum incubated for 2 hrs in presence of Mg2+ by scintillation counting method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID625290 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID496818 | Antimicrobial activity against Trypanosoma brucei brucei | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID175137 | Compound was administered to male Sprague-Dawley rats (250-300 g) by intravenous (iv) bolus injection at a dose of 40 mg/kg | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. |
| AID496823 | Antimicrobial activity against Trichomonas vaginalis | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID222489 | Testing for ataxia was done by using an inverted screen technique | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Synthesis and pharmacological evaluation of 4a-phenanthrenamine derivatives acting at the phencyclidine binding site of the N-methyl-D-aspartate receptor complex. |
| AID625283 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1692763 | Octanol-water partition coefficient, log P of the compound | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1692769 | Bioavailability in iv dosed human | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID24432 | Partition coefficient was measured using a standard shake flask (SF) method at pH 7.4. | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Synthesis and pharmacological evaluation of 4a-phenanthrenamine derivatives acting at the phencyclidine binding site of the N-methyl-D-aspartate receptor complex. |
| AID1692784 | Distribution half life in human brain | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1692799 | Displacement of [3H]-MK801 from NMDA receptor in Sprague-Dawley rat cortex incubated for 2 hrs in presence of Mg2+ by scintillation counting method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | |||
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | |||
| AID496831 | Antimicrobial activity against Cryptosporidium parvum | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID496830 | Antimicrobial activity against Leishmania major | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID1692789 | Displacement of [3H]-MK801 from NMDA receptor in ICR Harlan mouse brain homogenate incubated for 45 mins by liquid scintillation spectrometry | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID480451 | Inhibition of electric eel AChE at 10 uM by modified Ellman's method | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. |
| AID1692791 | Displacement of [3H]-MK801 from NMDA receptor in dog brain homogenate incubated for 45 mins by liquid scintillation spectrometry | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID21248 | Partition coefficient was expressed as the ratio of the equilibrium concentration in n-heptane solvent to that in an equal volume of pH 7.4 aqueous buffer | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. |
| AID1702357 | Antidepressant-like activity in Wistar rat assessed as reduction in immobility time at 15 mg/kg, ip administered 60 mins prior to testing and measured for 5 mins test period by Porsolt-forced swim test | |||
| AID765753 | Anesthetic effect in iv dosed Sprague-Dawley rat assessed as duration of loss of righting reflex | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17 | Structure-activity relationships for ketamine esters as short-acting anaesthetics. |
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | |||
| AID1502362 | Antidepressant activity in CD-1 mouse assessed as reduction in immobility time at 30 mg/kg administered ip 15 mins prior to test measured for 6 mins by tail suspension test | |||
| AID1692781 | Elimination half life in Wistar rat at 20 mg/kg, iv by LC-MS analysis | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1456862 | Antidepressant-like activity in Harlan Sprague-Dawley rat assessed as reduction in immobility time at 10 mg/kg, ip administered 30 mins prior to test measured for 6 mins by forced swim test | |||
| AID480464 | Cytotoxicity against mouse L12-G10 cells at 50 uM by MTT assay | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. |
| AID1692772 | Bioavailability in REC dosed human | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1692780 | Elimination half life in human | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1692771 | Bioavailability in IN dosed human | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1692800 | Displacement of [3H]-MK801 from NMDA receptor in human cortex incubated for 2 hrs in presence of Mg2+ by scintillation counting method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1692801 | Displacement of [3H]-MK801 from human forebrain GluN1/GluN2B expressed in HEK293 cells by at -70 mV holding potential by patch-clamp assay | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID497005 | Antimicrobial activity against Pneumocystis carinii | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID225475 | Ability to inhibit glutamate induced accumulation of [45 [Ca2+]] in cultured rat cortical neurons | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14 | Synthesis and pharmacological evaluation of 4a-phenanthrenamine derivatives acting at the phencyclidine binding site of the N-methyl-D-aspartate receptor complex. |
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | |||
| AID1079942 | Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] | |||
| AID1692807 | Anesthetic activity in IM dosed human assessed as time duration of action | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID540210 | Clearance in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID1692795 | Displacement of [3H]-MK801 from NMDA receptor in Sprague-Dawley rat brain synaptic membrane incubated for 60 mins by liquid scintillation counting method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID540209 | Volume of distribution at steady state in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID1692762 | Inhibition of NMDAR-mediated excitatory postsynaptic potential in Sprague-Dawley rat hippocampus CA1 region by electrophysiology | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID175138 | Compound was administered to male Sprague-Dawley rats (250-300 g) by intravenous (iv) bolus injection at a dose of 40 mg/kg | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. |
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | |||
| AID625284 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | |||
| AID496817 | Antimicrobial activity against Trypanosoma cruzi | 2010 | Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6 | Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. |
| AID540212 | Mean residence time in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID480449 | Inhibition of equine serum BChE by modified Ellman's method | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. |
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | |||
| AID588213 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID1909462 | Inhibition of GluN1/N2A (unknown origin) expressed in human tsA201 cells assessed as glutamate-induced change in voltage at -65 mV holding potential for 30 secs by whole-cell patch-clamp method | 2022 | European journal of medicinal chemistry, Jun-05, Volume: 236 | Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease. |
| AID1602884 | Binding affinity to NMDA receptor (unknown origin) | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Ketamine esters and amides as short-acting anaesthetics: Structure-activity relationships for the side-chain. |
| AID480460 | Inhibition of human NR1-1a/NR2A receptor-mediated excitotoxicity mouse L12-G10 cells assessed as LDH release after 30 mins in absence of (S)-glutamate/glycine relative to control | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. |
| AID156805 | The compound was tested for its ability to block PCP N-methyl-D-aspartate glutamate receptor at the PCP (phencyclidine) binding site in postmortem human frontal cortex. | 1998 | Journal of medicinal chemistry, Jan-29, Volume: 41, Issue:3 | Quantitative analysis of the structural requirements for blockade of the N-methyl-D-aspartate receptor at the phencyclidine binding site. |
| AID1692760 | Displacement of [3H]-MK801 from NMDA receptor in rat brain membranes incubated for 2 hrs in presence of Mg2+ by radioligand binding assay | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID1692787 | Displacement of [3H]-MK801 from NMDA receptor in human frontal cortex in presence of Mg2+ by scintillation counting method | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22 | Repurposing of Drugs-The Ketamine Story. |
| AID625289 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID480457 | Inhibition of dexamethasone-induced human NR1-1a/NR2A receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L12-G10 cells assessed as LDH release at 100 uM after 30 mins | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. |
| AID480453 | Inhibition of dexamethasone-induced human NR1-1a/NR2A receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L12-G10 cells assessed as LDH release after 30 mins | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1508612 | NCATS Parallel Artificial Membrane Permeability Assay (PAMPA) Profiling | 2017 | Bioorganic & medicinal chemistry, 02-01, Volume: 25, Issue:3 | Highly predictive and interpretable models for PAMPA permeability. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID504749 | qHTS profiling for inhibitors of Plasmodium falciparum proliferation | 2011 | Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043 | Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. |
| AID1508591 | NCATS Rat Liver Microsome Stability Profiling | 2020 | Scientific reports, 11-26, Volume: 10, Issue:1 | Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models. |
| AID1645848 | NCATS Kinetic Aqueous Solubility Profiling | 2019 | Bioorganic & medicinal chemistry, 07-15, Volume: 27, Issue:14 | Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity. |
| AID1346601 | Human GluN2C (Ionotropic glutamate receptors) | 2007 | The Journal of physiology, May-15, Volume: 581, Issue:Pt 1 | Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2609 (18.77) | 18.7374 |
| 1990's | 1752 (12.61) | 18.2507 |
| 2000's | 2525 (18.17) | 29.6817 |
| 2010's | 4540 (32.67) | 24.3611 |
| 2020's | 2471 (17.78) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (125.54) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 2,321 (15.44%) | 5.53% |
| Reviews | 1,454 (9.67%) | 6.00% |
| Case Studies | 982 (6.53%) | 4.05% |
| Observational | 97 (0.65%) | 0.25% |
| Other | 10,175 (67.70%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of the Efficacy and Safety of EpiCept™ NP-1 Topical Cream in Patients With Pain From Diabetic Peripheral Neuropathy (DPN) [NCT00476151] | Phase 2 | 226 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| A Phase 1, Double-Blind, Placebo-Controlled Crossover Study of SAGE-904 Using a Ketamine Challenge to Evaluate Electrophysiology, Safety, Tolerability, and Pharmacokinetics in Healthy Participants [NCT05049343] | Phase 1 | 22 participants (Actual) | Interventional | 2021-09-21 | Completed | ||
| Assessment of the Analgesic Efficacy and Tolerability of the Perioperative Association of the Ketamine With Opiates After Posterior Vertebral Fusion Surgery in Children With Idiopathic Scoliosis [NCT02571491] | Phase 2 | 48 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| Effect of Perioperative i.v. Low-dose S(+) Ketamine in Patients Undergoing Hemorrhoidectomy [NCT00354029] | Phase 4 | 83 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| Impact of Ketamine Versus Propofol for Anesthetic Induction on Acute Kidney Injury and Renal Biomarkers in Cardiac Surgery [NCT05268562] | Phase 4 | 200 participants (Anticipated) | Interventional | 2022-03-02 | Recruiting | ||
| Effects of NMDA Receptor Antagonism on Cognitive Processes in Healthy Volunteers and Its Reversal by a Dopamine Antagonist: Comparison to Patients With Schizophrenia [NCT01140620] | Phase 4 | 87 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Importance of Integrated Pulmonary Index in Pediatric Patients Undergoing Endoscopy Procedures Under Sedation [NCT05137574] | 60 participants (Actual) | Interventional | 2021-05-10 | Completed | |||
| CAP-Ketamine for Antidepressant Resistant PTSD [NCT02655692] | Phase 2 | 163 participants (Actual) | Interventional | 2016-04-18 | Completed | ||
| Ketamine's Effect Changes the Cortical Electrophysiological Activity Related to Semantic Affective Dimension of Pain: a Placebo-controlled Study in Healthy Male Subjects [NCT03915938] | Phase 2/Phase 3 | 24 participants (Actual) | Interventional | 2017-01-02 | Completed | ||
| Evaluation of Post Operative Pain Following Primary Total Knee Arthroplasty (TKA) With Intraoperative Subanesthetic Ketamine Administration and Spinal Anesthesia [NCT03865550] | 75 participants (Anticipated) | Interventional | 2016-03-28 | Active, not recruiting | |||
| Ketamine as an Adjunctive Treatment of Acute Suicidal Ideation in the Emergency Setting. [NCT02183272] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2016-08-31 | Recruiting | ||
| Criteria Based Discharge in Ambulatory Surgery in Children Undergoing Opioid Versus Opioid Free Anesthesia [NCT03979469] | Phase 2 | 100 participants (Actual) | Interventional | 2018-08-01 | Completed | ||
| The Use of Ketamine as an Anaesthetic During Electroconvulsive Therapy (ECT) for Depression: Does it Improve Treatment Outcome? [NCT01306760] | Phase 4 | 40 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| KETODEX for Emergence Delirium in Children Undergoing Outpatient Strabismus Surgery [NCT03779282] | 90 participants (Actual) | Observational | 2018-02-15 | Completed | |||
| Does Subanesthetic Dose of Ketamine Given at Induction of Anesthesia Improve Postoperative Mood In Women Undergoing Fractional Curettage? A Randomized Controlled Trial [NCT05752110] | Phase 4 | 140 participants (Actual) | Interventional | 2022-04-01 | Completed | ||
| A Comparative Study Between Dexamethasone and Ketamine as Adjuvants to Bupivacaine for Incisional Infiltration in Pediatric Abdominal Operations [NCT05190952] | 150 participants (Actual) | Interventional | 2020-12-05 | Completed | |||
| A Randomized, Double-blind, Placebo-Controlled, 3-Period Crossover Study Followed by 1 Open-label Comparator Period to Evaluate Central Nervous System Pharmacodynamic Activity of TAK-653 in Healthy Volunteers Using Transcranial Magnetic Stimulation [NCT03792672] | Phase 1 | 24 participants (Actual) | Interventional | 2019-02-11 | Completed | ||
| Pilot Study Probing the Antidepressant Effects of 0.5 mg/kg Intravenous Ketamine in Drug-resistant Depressed Patients (Unipolar Depression): Efficacy, Safety, Brain Function [NCT01135758] | Phase 2 | 10 participants (Actual) | Interventional | 2010-06-30 | Terminated(stopped due to End of funding of study) | ||
| Morphine Versus Ketamine as Adjuvants in Ultrasound-guided Paravertebral Thoracic Blocks in Elective Thoracic Surgery [NCT04852484] | 90 participants (Anticipated) | Interventional | 2021-04-16 | Active, not recruiting | |||
| Glutamatergic Modulation as a Treatment for Depressive Symptoms Among Patients With Post-acute Sequelae of COVID (PASC): A Pilot Trial [NCT05690503] | Phase 2 | 12 participants (Anticipated) | Interventional | 2023-03-20 | Recruiting | ||
| Ketamine-assisted Psychotherapy for the Treatment of Persistent Depression in Abstinent Opioid Users [NCT05193318] | Phase 2 | 5 participants (Actual) | Interventional | 2022-01-13 | Terminated(stopped due to Primary Investigator leaving institution) | ||
| Ultrasound Guided Fascia Iliaca Nerve Block With Bupivacaine and Adjuvant Ketamine vs. Bupivacaine Alone in Patients With Hip or Femur Fracture: a Double Blind Randomized Clinical Trial (BupiKet) [NCT03909594] | Phase 4 | 0 participants (Actual) | Interventional | 2022-01-01 | Withdrawn(stopped due to The COVID Pandemic delayed start of study and currently the investigators are not interested in conducting the study.) | ||
| Ketamine for Refractory Chronic Migraine: a Pilot Study [NCT03896256] | Early Phase 1 | 6 participants (Actual) | Interventional | 2019-03-22 | Completed | ||
| Efficacy of Ketamine-fentanyl VS Fentanyl for Analgosedation in Postoperative Ventilated SICU Patients [NCT03879564] | Phase 4 | 124 participants (Anticipated) | Interventional | 2019-04-05 | Active, not recruiting | ||
| Oral Ketamine as an Adjuvant to Opioids for Pain Treatment in Cancer Patients [NCT01207206] | 50 participants (Anticipated) | Interventional | 2010-10-31 | Recruiting | |||
| Safety, Tolerance and Pharmacokinetics of Hydrochloric Acid (R) -Ketamine Nasal Spray in Healthy Subjects: A Randomized, Double Blind, Placebo-Controlled Phase I Clinical Trial [NCT04108234] | Phase 1 | 50 participants (Actual) | Interventional | 2019-10-24 | Completed | ||
| A Phase 1, Double-blind, Placebo-controlled Crossover Study of SAGE-718 Using a Ketamine Challenge, to Evaluate the Electrophysiology, Safety, Tolerability, and Pharmacokinetics in Healthy Subjects [NCT03771586] | Phase 1 | 22 participants (Actual) | Interventional | 2018-09-24 | Completed | ||
| A Randomized Placebo-controlled Pilot Study of Single-dose Intraoperative Ketamine for the Prevention of Delirium in Otolaryngeal Cancer Surgery Patients [NCT03040024] | Phase 4 | 71 participants (Actual) | Interventional | 2017-03-17 | Terminated(stopped due to Halted due to COVID 19; we believe we have adequate data for analysis) | ||
| Paravertebral Nerve Blocks in Neonates and Infants Undergoing Repair of Aortic Coarctation, A Pilot Study [NCT03408340] | Phase 4 | 30 participants (Anticipated) | Interventional | 2018-07-18 | Recruiting | ||
| Effects of İntraarticular and Periarticular Applied Drugs on Postoperative Pain Management in Artroscopic Knee Surgery for [NCT03955809] | Phase 4 | 75 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| Electroencephalogram Studies of Induction and Recovery From Ketamine-Induced General Anesthesia [NCT03553758] | Phase 2/Phase 3 | 16 participants (Actual) | Interventional | 2018-11-01 | Completed | ||
| The Effect of Ketamine Between Generations in Operation Theater- Focus on Electroencephalogram Changes [NCT03679390] | 17 participants (Actual) | Interventional | 2017-03-01 | Terminated(stopped due to no funding) | |||
| Effect of Perioperative Low Dose Ketamine on Postoperative Recovery in Patients Undergoing Breast Cancer Surgery [NCT03676114] | Phase 4 | 100 participants (Anticipated) | Interventional | 2018-09-20 | Recruiting | ||
| Evaluation of the Efficacy of Preoperative Ketamine Nebulization on Postoperative Sore Throat Due to Tracheal Intubation for Adult Patients Under General Anesthesia, A Prospective Randomized Controlled Study [NCT05975346] | 80 participants (Anticipated) | Observational | 2023-08-31 | Not yet recruiting | |||
| Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder [NCT03658330] | Phase 2 | 5 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| Subdissociative Dose Ketamine for Treatment of Acute Pain in Subjects With Chronic Pain: A Randomized Controlled Trial [NCT02920528] | Phase 3 | 106 participants (Actual) | Interventional | 2017-05-01 | Completed | ||
| ERASE: Evaluation of the Relationship of the Anesthetic Agent Ketamine and Psychological Sequelae [NCT04053400] | 159 participants (Actual) | Observational | 2014-12-31 | Completed | |||
| Intravenous Lidocaine for Perioperative and Postoperative Analgesia [NCT03921567] | Phase 4 | 520 participants (Anticipated) | Interventional | 2019-04-15 | Recruiting | ||
| Lidocaine as an Adjuvant for Ketamine in Induction of Anesthesia in Septic Shock Patients: a Randomized Controlled Trial [NCT03640468] | Phase 3 | 36 participants (Anticipated) | Interventional | 2018-12-20 | Not yet recruiting | ||
| Pre-hospital Care With Intra-Nasal Ketamine for Transport (PRECINKT): A Pilot Study [NCT02033434] | Phase 1 | 30 participants (Actual) | Interventional | 2014-03-01 | Completed | ||
| Brain Activation Patterns Under Emotional and Neurochemic Stimulation With Ketamine: A Multimodal Neuroimaging Study [NCT03609190] | Early Phase 1 | 10 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Importance of Integrated Pulmonary Index in Pediatric Patients Undergoing Bronchoscopy Procedures Under Sedation [NCT05137587] | 60 participants (Actual) | Interventional | 2022-09-01 | Completed | |||
| Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain [NCT02527083] | Phase 4 | 10 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Use of Transmucosal Ketamine in Post Stroke Depression [NCT04876066] | Phase 1 | 21 participants (Anticipated) | Interventional | 2020-11-30 | Recruiting | ||
| Fentanyl vs. Low-Dose Ketamine for the Relief of Moderate to Severe Pain in Aeromedical Patients [NCT01169025] | 0 participants (Actual) | Interventional | 2012-09-30 | Withdrawn | |||
| A Multi-center, Randomized, subject-and Investigator Blinded, Placebo-controlled, Active Comparator, Parallel-group Proof of Concept Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of MIJ821 in Patients With Treatment-resistant D [NCT03756129] | Phase 2 | 70 participants (Actual) | Interventional | 2019-02-08 | Completed | ||
| The Effect of Ketamine on Production of Inflammatory Markers in Post Operative Patients in Mulago Hospital: A Randomized Clinical Trial [NCT01339065] | Phase 4 | 30 participants (Anticipated) | Interventional | 2011-04-30 | Recruiting | ||
| Adding Ketamine to Low Dose Bupivacaine in Saddle Block for Perianal Surgery [NCT03264430] | Early Phase 1 | 60 participants (Actual) | Interventional | 2017-01-01 | Active, not recruiting | ||
| Ketamine-based Versus Opioid-based for Rapid-sequence Induction of Anesthesia in Patients With Septic Shock [NCT03251170] | Phase 4 | 42 participants (Actual) | Interventional | 2018-01-25 | Completed | ||
| Laryngeal Mask Insertion Conditions And Hemodynamic Effects After Propofol And Ketamine-Propofol Co-induction [NCT03257800] | 120 participants (Actual) | Interventional | 2013-06-01 | Completed | |||
| Neuroprotection During Open Heart Surgery Propofol Versus Ketofol [NCT04486690] | Phase 3 | 50 participants (Actual) | Interventional | 2016-07-01 | Completed | ||
| Combining Neurobiology and New Learning: Ketamine and Prolonged Exposure: A Potential Rapid Treatment for Post Traumatic Stress Disorder (PTSD) [NCT02727998] | Phase 2 | 28 participants (Actual) | Interventional | 2015-12-31 | Terminated(stopped due to Study ran out of funding) | ||
| Effects of Local Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Inflammatory Cytokines Response After Total Abdominal Hysterectomy [NCT03164590] | Phase 4 | 60 participants (Actual) | Interventional | 2017-06-01 | Completed | ||
| Ketamine Co-induction for Patients With Major Depressive Disorder; a Randomized Clinical Trial [NCT03666494] | Phase 4 | 50 participants (Anticipated) | Interventional | 2018-12-31 | Not yet recruiting | ||
| Does Low-Dose Ketamine Infusion or Intravenous Morphine Infusion During Abdominoplasty Change Postoperative Pain Profile? : A Double-Blind, Randomized, Controlled Clinical Trial [NCT03664622] | 160 participants (Actual) | Interventional | 2018-09-15 | Completed | |||
| A Prospective, Block Randomized, Double-Blind Placebo-Controlled Trial of Ketamine in Patients Undergoing Anterior Cervical Discectomy and Fusion [NCT02378740] | Phase 4 | 0 participants (Actual) | Interventional | 2015-04-30 | Withdrawn(stopped due to PI has left the University) | ||
| A Randomized, Double-Blind Study of Placebo vs. Ketamine For Use During Dressing Changes in Critically Ill Burn Patients [NCT02336308] | Phase 4 | 0 participants (Actual) | Interventional | 2015-01-31 | Withdrawn(stopped due to Standard of care for dressing changes at the institution now includes treatment intervention) | ||
| Sequential Therapy (NRX-100 Followed by NRX-101) for the Treatment of Acute Suicidal Ideation and Behavior in Bipolar Depression: the STABIL-B Study [NCT02974010] | Phase 2 | 22 participants (Actual) | Interventional | 2018-01-15 | Completed | ||
| A Comparison of Ketofol (Ketamine and Propofol Admixture) vs. Propofol as Induction Agents on Hemodynamic Parameters [NCT01065350] | 85 participants (Actual) | Interventional | 2010-12-31 | Completed | |||
| Analgesic Efficacy of Intra-muscular Ketamine-ketorolac Versus Fentanyl- Ketorolac for Children Undergoing Bone Marrow Biopsy and Aspiration [NCT03649334] | Phase 4 | 80 participants (Actual) | Interventional | 2018-08-26 | Completed | ||
| Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Procedural Sedation in Children: a Randomized Controlled Trial [NCT04820205] | 136 participants (Anticipated) | Interventional | 2021-09-03 | Recruiting | |||
| A Prospective, Randomized, Double Blinded Comparison of Ketamine Infusion Versus Placebo in Opioid Tolerant and Opioid Naive Patients After Spinal Fusion [NCT03274453] | Phase 2 | 129 participants (Actual) | Interventional | 2012-11-01 | Completed | ||
| Co-induction Ketamine-propofol: the Effects on Laryngeal Mask Airway Insertion Conditions and Resulting Hemodynamic Changes in Children [NCT03631875] | Phase 4 | 120 participants (Actual) | Interventional | 2019-05-01 | Completed | ||
| A Double-blind, Randomized-controlled Trial Using a Low Dose of Ketamine vs. Active Placebo in Treating Severe Depression and Suicide [NCT03666390] | 48 participants (Anticipated) | Interventional | 2018-09-10 | Recruiting | |||
| Combined Platelet Rich Plasma Intra-articular Shoulder Injection and Stellate Ganglion Block. A New Technique for Management of Chronic Post-mastectomy Shoulder Pain Syndrome [NCT03586154] | Phase 4 | 70 participants (Actual) | Interventional | 2017-08-01 | Completed | ||
| Ultrasound-guided (US) Serratus Anterior Plane Block (SAPB) for Acute Rib Fractures in the Emergency Department (ED) [NCT03619785] | Phase 4 | 70 participants (Anticipated) | Interventional | 2018-11-06 | Recruiting | ||
| The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction in Patients 75 Years of Age or Older and Undergoing Cardiac Surgery [NCT02554253] | Phase 2 | 52 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| A Randomized, Double-Blinded, Placebo-Controlled Study Evaluating Phenobarbital and Ketamine Adjunctive Therapies in the Treatment of Alcohol Withdrawal Syndrome [NCT03788889] | Phase 4 | 0 participants (Actual) | Interventional | 2019-04-12 | Withdrawn(stopped due to internal practice and policy limitations including time commitment / workflow issues) | ||
| Comparison of BIS Index Variations When i.v. Low-dose Ketamine is Administered Intraoperatively as Bolus Versus Continuous Infusion and Impact on the Anesthesia Gas Consumption. [NCT03781635] | Phase 4 | 50 participants (Actual) | Interventional | 2018-09-25 | Completed | ||
| The Effect of Different Anesthetic Agents Management on Electrocardiographic Changes of Patients Who Were Operated Under Regional Intravenous Anesthesia [NCT02063620] | 60 participants (Actual) | Interventional | 2013-10-31 | Completed | |||
| Unraveling the Aesthetic Mind in Anhedonia, Insights From Pharmacological Imaging of the Human Brain: A Single-blind, Randomized, Placebo-controlled Cross-over Study [NCT05320107] | Phase 1 | 60 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting | ||
| KetaMoHydBup: Pharmacokinetic Interaction of S-ketamine, Morphine, Hydromorphone and Buprenorphine [NCT05571176] | Phase 1 | 12 participants (Anticipated) | Interventional | 2023-01-31 | Not yet recruiting | ||
| A Comparison of the Effects of Ketamine and Remifentanil on Serum Cystatin-c Levels in CABG Surgery [NCT02113150] | Phase 4 | 37 participants (Actual) | Interventional | 2013-05-31 | Completed | ||
| HNC: Human Neural Circuits Electrophysiology During Cognition [NCT05962424] | Phase 1 | 120 participants (Anticipated) | Interventional | 2023-10-05 | Recruiting | ||
| Prehospital Analgesia INtervention Trial (PAIN) [NCT05437575] | Phase 3 | 994 participants (Anticipated) | Interventional | 2023-11-27 | Recruiting | ||
| Low Dose Intraoperative Intravenous Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study [NCT02570230] | Phase 4 | 32 participants (Actual) | Interventional | 2017-10-01 | Completed | ||
| The Use of Sedation Drugs in the Procedure of Administering Surfactant Without Intubation (LISA/MIST): a Randomized Study Comparing Intravenous Ketamine With Sublingual 30% Glucose [NCT04409665] | Phase 1 | 60 participants (Anticipated) | Interventional | 2020-01-01 | Recruiting | ||
| Comparison of Ketamine-propofol Sedation Protocols With Fentanyl-propofol Administered by Endoscopist or Anesthesiologist at Colonoscopy [NCT03607110] | 120 participants (Actual) | Observational | 2018-03-01 | Completed | |||
| Impact of Dexmedetomidine Versus Ketamine Soaked Pharyngeal Packing on Postoperative Sore Throat in Functional Endoscopic Sinus Surgery: a Randomized Double Blind Trial [NCT04955158] | Phase 3 | 143 participants (Actual) | Interventional | 2021-08-19 | Completed | ||
| Diaphragmatic Function, Pain Quality & Anti-inflammatory Properties: A Low Dose Dexmedetomidine Versus Ketamine in Patients With Multiple Fracture Ribs Needing Conservative Treatment [NCT04928300] | Phase 3 | 90 participants (Anticipated) | Interventional | 2021-06-12 | Recruiting | ||
| The Effect of a Narcotic Free Total Intravenous Anesthesia on the Outcome and Patient Safety During Anterior Cervical Discectomy and Fusion (ACDF) Surgery: A Randomized Controlled Trial [NCT03643796] | Phase 4 | 32 participants (Actual) | Interventional | 2018-07-15 | Completed | ||
| Mapping the Influence of Drugs of Abuse on Risk and Reward Circuits [NCT03475277] | 40 participants (Anticipated) | Observational | 2019-07-30 | Recruiting | |||
| UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study [NCT03284307] | Phase 4 | 35 participants (Actual) | Interventional | 2017-08-10 | Completed | ||
| A Systematic Investigation of Neurophysiological Correlates of Low Dose Intravenous Ketamine in Treatment Resistant Depression Patients [NCT02935595] | Phase 2 | 9 participants (Actual) | Interventional | 2016-10-14 | Completed | ||
| A Randomized, Single-blind, Parallel-group Study to Evaluate the Effects of TS-134 on Ketamine-induced BOLD Signals in Resting fMRI in Healthy Adult Subjects [NCT03141658] | Phase 1 | 63 participants (Actual) | Interventional | 2017-06-28 | Completed | ||
| Early Low-dose Ketamine Infusion Versus Usual Care for Sickle Cell Pain Crisis: a Randomized, Prospective Study. [NCT04005209] | Phase 4 | 0 participants (Actual) | Interventional | 2022-01-31 | Withdrawn(stopped due to Decided not to open study) | ||
| Pharmacokinetics of Antiepileptic Drugs in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy [NCT03632915] | 18 participants (Actual) | Observational | 2017-11-20 | Completed | |||
| Opioid Free vs Opioid Based Anesthesia for Laparoscopic Sleeve Gastrectomy: Clinical, Randomised Study [NCT04260659] | Phase 4 | 59 participants (Actual) | Interventional | 2020-02-04 | Completed | ||
| The Effects of Low Dose Ketamine on Cardiovascular Function [NCT04429685] | Phase 1 | 6 participants (Actual) | Interventional | 2020-11-01 | Terminated(stopped due to The focus of the laboratory went a different direction given extramural funding) | ||
| Comparison of Nebulized Sub-dissociative Dose Ketamine at Three Different Dosing Regimens for Treating Acute and Chronic Painful Conditions in the ED: A Prospective, Randomized Trial [NCT03909607] | Phase 4 | 120 participants (Actual) | Interventional | 2019-04-16 | Completed | ||
| Investigate the Effect of S-Ketamine, as Pharmacological Model of Schizophrenia, on the Attentiveness and Working Memory Simultaneously Measured With Functional Magnetic Resonance Imaging(fMRI)/Electroencephalogram(EEG) [NCT01165294] | Phase 1 | 24 participants (Actual) | Interventional | 2009-10-31 | Completed | ||
| Analgesia During Pediatric Digestive Endoscopy: a Comparison of Two Protocols for Procedural Sedation [NCT01168492] | Phase 4 | 90 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| Comparison Between the Analgesic Effects of Intrathecal Versus Intravenous Ketamine After Spinal Anaesthesia for Elective Caesarean Delivery :a Randomised Trial [NCT05679375] | Phase 4 | 60 participants (Anticipated) | Interventional | 2023-01-31 | Not yet recruiting | ||
| The Ketamine for Acute Postoperative Analgesia (KAPA) Trial [NCT04646694] | Phase 3 | 40 participants (Actual) | Interventional | 2020-11-17 | Completed | ||
| Lidocaine-Ketamine Versus Ketamine for Induction of Anesthesia in Septic Shock Patients: a Randomized Controlled Trial [NCT03844984] | Phase 3 | 43 participants (Actual) | Interventional | 2019-02-20 | Completed | ||
| Comparison of Peritonsillar Infiltration of Ketamine and Dexamethasone for Postoperative Pain Relief in Children Following Adenotonsillectomy [NCT01198210] | Phase 1/Phase 2 | 160 participants (Anticipated) | Interventional | 2010-07-31 | Recruiting | ||
| Characterizing Clinical and Pharmacological Neuroimaging Biomarkers [NCT03842800] | Early Phase 1 | 143 participants (Actual) | Interventional | 2013-04-01 | Completed | ||
| A Two-part, Single-dose, Randomized, Double-blind, Placebo and Active-Controlled Crossover Study to Evaluate the Abuse Potential of Rapastinel in Healthy, Non-dependent, Adult Recreational Polydrug Users [NCT03799900] | Phase 1 | 72 participants (Actual) | Interventional | 2018-11-01 | Completed | ||
| Continuation Riluzole in the Prevention of Relapse Following Ketamine in Major Depression [NCT00419003] | Phase 4 | 26 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| Fentanyl Versus Ketamine Supplementation for Prpofol Anesthesia During Balloon Insertion in Morbidly Obese Patients [NCT03747094] | 70 participants (Anticipated) | Interventional | 2018-12-01 | Not yet recruiting | |||
| A Phase 1 Pharmacokinetics and Pharmacodynamics of Ketamine Transdermal Drug Delivery System in Subjects With Sub-Optimally Responsive Major Depressive Disorders [NCT03721900] | Phase 1 | 14 participants (Anticipated) | Interventional | 2018-12-28 | Active, not recruiting | ||
| Effect of Intravenous Ketamine Infusion for Hemodynamic Stability in Patients Undergoing Cesarean Delivery [NCT05865080] | 126 participants (Actual) | Interventional | 2022-07-01 | Completed | |||
| Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients [NCT02989597] | Phase 4 | 10 participants (Actual) | Interventional | 2017-07-29 | Terminated(stopped due to Due to personnel loss and logistical issues the study was unable to be completed as planned.) | ||
| An Open-Label Clinical Trial of Simultaneous Administration of Oral Aspirin and Ketamine as Adjunct to Oral Antidepressant Therapy in Treatment-Resistant Depression [NCT05615948] | Phase 4 | 20 participants (Anticipated) | Interventional | 2022-12-06 | Recruiting | ||
| Ketamine, Lidocaine and Combination for Postoperative Analgesia in Open Liver Resection: A Prospective, Randomized, Four-arm, Double Blind, Placebo Controlled Trial [NCT03391427] | 124 participants (Actual) | Interventional | 2011-03-01 | Completed | |||
| Comparison of N2O Inhalation and Ketamine IV Injection for Sedation in the Treatment of Laceration of Pediatric Patients. [NCT00834730] | Phase 4 | 32 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| Infra-orbital Nerve Block for Post Operative Analgesia in Young Children Undergoing Pediatric Cleft Lip Surgery. [NCT02514980] | Phase 2/Phase 3 | 30 participants (Actual) | Interventional | 2015-08-31 | Completed | ||
| An Open Label Study of Electroencephalographic Responses Pre, During and Post, a Low Dose, Weekly Intravenous Ketamine Infusion for 4 Weeks, in a Study Population With Major Depression Disorder [NCT05506462] | Phase 4 | 35 participants (Anticipated) | Interventional | 2023-01-31 | Not yet recruiting | ||
| The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects [NCT05786066] | Phase 2 | 30 participants (Anticipated) | Interventional | 2023-04-03 | Recruiting | ||
| OBSERVATIONAL STUDY OF THE MANAGEMENT OF PATIENTS WITH CHRONIC PAIN [NCT03319238] | 1,000 participants (Anticipated) | Observational | 2016-07-07 | Recruiting | |||
| The Use Of Intranasal (IN) Ketamine For Pain Control In Patients With Sickle Cell Disease And Vaso-occlusive Episode (VOE) In The Pediatric Emergency Department [NCT04150757] | Phase 3 | 40 participants (Anticipated) | Interventional | 2020-08-21 | Recruiting | ||
| Intranasal Ketamine for Procedural Sedation: a Feasibility Cohort Study [NCT05783492] | Phase 3 | 0 participants (Actual) | Interventional | 2024-01-01 | Withdrawn(stopped due to Lack of availability of drug) | ||
| Efficacy of Combined Ketamine and Midazolam for Treatment of Generalized Convulsive Status Epilepticus in Children . [NCT05779657] | Phase 2/Phase 3 | 144 participants (Anticipated) | Interventional | 2023-03-21 | Recruiting | ||
| A Randomized, Controlled, Single-Blind, Phase 2 Study in Treatment Resistant Major Depressive Disorder Patients Receiving Intranasal Esketamine (SpravatoTM) Over a 28-day Period Comparing Addition of Almond TherapyTM With Treatment-as-Usual [NCT05323019] | Phase 2 | 6 participants (Actual) | Interventional | 2022-10-13 | Terminated(stopped due to Funding) | ||
| Feasibility Study Comparing a Ketamine and Midazolam Infusion to a Midazolam-Only Infusion for Complex Regional Pain Syndrome [NCT05945147] | Phase 2 | 4 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | ||
| Randomized Controlled Trial of IN Midazolam vs IN Dexmedetomidine vs IN Ketamine Evaluating Length of Stay After Medication Administration and Anxiolysis During Minimal Procedures in Pediatric Population in Pediatric Emergency Department [NCT05934669] | Phase 4 | 90 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use Disorder [NCT05421065] | Phase 2 | 20 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Intraoperative Ketamine Administration in Colorectal Surgery: Effect on Postoperative Clinical Outcomes [NCT01365195] | Phase 4 | 21 participants (Actual) | Interventional | 2011-05-31 | Terminated(stopped due to recruitment failure) | ||
| Oral Morphine Versus Rectal Ketamine in Pain Management During Burns Wound Dressing Changes in Paediatric Population at Mbarara Regional Referral Hospital: An Open Label Randomized Trial [NCT05163366] | Phase 3 | 44 participants (Actual) | Interventional | 2021-03-01 | Completed | ||
| Caudal Epidural Block Versus Topical Ketamine Application for Postoperative Pain Relief After Elective Inguinal Herniotomy [NCT02462174] | Phase 2/Phase 3 | 80 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| Naloxone Block of Low-dose (Analgetic Dose) Ketamine [NCT00921765] | Phase 4 | 3 participants (Actual) | Interventional | 2009-12-31 | Terminated(stopped due to Problems with patient recruitment) | ||
| Opioid Free Anesthesia for Upper Limb Surgery in Obese Patients. [NCT05481970] | 76 participants (Anticipated) | Interventional | 2022-09-30 | Not yet recruiting | |||
| Efficacy of Intra-articular Neostigmine Versus Ketamine for Postoperative Analgesia in Arthroscopic Knee Surgery [NCT03248648] | Phase 2/Phase 3 | 100 participants (Actual) | Interventional | 2017-03-01 | Completed | ||
| Open Study of the Neurobiological Effects of Intranasal Ketamine in Children and Adults With Bipolar Disorder - Fear of Harm Phenotype [NCT05209217] | 20 participants (Anticipated) | Observational | 2019-06-04 | Recruiting | |||
| The Effects of Combination of Intravenous Dexamethasone and Ketamine on Change of Postoperative Mood in Patients Undergoing Laparoscopically Assisted Gynecologic Surgery. [NCT03194594] | Phase 4 | 93 participants (Actual) | Interventional | 2017-05-02 | Completed | ||
| A Randomized Pilot Trial of Intramuscular Ketamine and Crisis Response Planning for Suicide Prevention in the Emergency Department [NCT05696691] | Phase 2/Phase 3 | 24 participants (Anticipated) | Interventional | 2023-01-06 | Recruiting | ||
| Ketamine Infusion for Pediatric Patients With Obstructive Sleep Apnea Syndrome After Tonsillectomy: A Randomized Controlled Trial [NCT02425202] | Phase 4 | 36 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| Comparing Therapeutic Efficacy and Cognitive Side Effects of Electroconvulsive Therapy (ECT) Using Ketamine Versus Methohexital Anesthesia [NCT01881763] | Phase 4 | 31 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| The Use of Propofol/Ketamine Anesthesia With Bispectral Monitoring (PKA-BIS) Versus Inhalational Anesthetics in Rhytidoplasty - A Prospective, Double-blinded, Randomized Comparison Study [NCT02410460] | 30 participants (Actual) | Interventional | 2013-09-30 | Completed | |||
| Ultra-low Dose Oral Ketamine for Treatment of Chronic Non-cancer Pain in the Primary Care Setting [NCT02303847] | Phase 3 | 32 participants (Anticipated) | Interventional | 2014-11-30 | Active, not recruiting | ||
| Comparison of Treatment by IN Ketamine to IV Morphine in Acute Pain [NCT03511833] | Phase 3 | 120 participants (Anticipated) | Interventional | 2019-12-31 | Not yet recruiting | ||
| Randomized Controlled Trial of Repeated Dose Ketamine in Post Traumatic Stress Disorder (PTSD) [NCT02398136] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2014-12-31 | Withdrawn(stopped due to FDA and IRB recommended different mode of medication administration) | ||
| Association of Intravenous Ketamine With Thoracic Epidural Analgesia: Effects on Pain and Respiratory Function Following Thoracotomy. [NCT00726258] | 21 participants (Actual) | Interventional | 2008-03-31 | Terminated | |||
| Inhaled Nebulised S(+)-Ketamine for Postoperative Analgesia [NCT02397356] | Phase 4 | 0 participants (Actual) | Interventional | 2018-08-31 | Withdrawn(stopped due to Lack of study personnel) | ||
| Effect of Ketamine on Fatigue Following Cancer Therapy [NCT02317341] | Early Phase 1 | 2 participants (Actual) | Interventional | 2014-12-13 | Terminated | ||
| ED Treatment of Suicidal Patients With Ketamine Infusion [NCT03502551] | Phase 2 | 0 participants (Actual) | Interventional | 2019-04-01 | Withdrawn(stopped due to Trial never received funding.) | ||
| Ketamine for the Treatment of Depression in Parkinson's Disease (KET-PD) [NCT04944017] | Phase 2 | 56 participants (Anticipated) | Interventional | 2021-11-23 | Recruiting | ||
| Observation of Ketamine Treatment Safety and Tolerability in Adult Psychiatry Clinic Medical University of Gdańsk Inpatients [NCT05565352] | 140 participants (Anticipated) | Observational | 2022-09-01 | Enrolling by invitation | |||
| Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Rescue After Failed Pediatric Procedural Sedation: a Randomized Controlled Trial [NCT04822064] | 70 participants (Anticipated) | Interventional | 2022-09-22 | Recruiting | |||
| Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression: An Open-Label Extension Trial [NCT05339074] | Phase 2 | 60 participants (Anticipated) | Interventional | 2022-08-10 | Recruiting | ||
| Effects of Low-dose S-ketamine on the Incidence of Postpartum Depression in Women With Prenatal Depression: a Randomized, Double-blind, Placebo-controlled Trial [NCT04414943] | 364 participants (Actual) | Interventional | 2020-06-19 | Completed | |||
| An Electrophysiological Examination of CB1 and NMDA Receptors in Humans [NCT04199468] | Phase 1 | 21 participants (Anticipated) | Interventional | 2019-09-24 | Active, not recruiting | ||
| Effects of Low-dose S-Ketamine on Incidence of Postpartum Depression in Parturients With Prenatal Depression: A Randomized, Double-blind, Placebo-controlled Trial [NCT03927378] | 364 participants (Actual) | Interventional | 2020-06-19 | Completed | |||
| Paravertebral Block Versus Simultaneous Ketamine and Lidocaine Infusions for Pain Management in Rib Fracture Patients [NCT04413799] | Early Phase 1 | 170 participants (Anticipated) | Interventional | 2020-09-01 | Recruiting | ||
| Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial [NCT02643381] | Phase 4 | 801 participants (Actual) | Interventional | 2016-06-06 | Completed | ||
| Touchscreen-based Cognitive Tests in Assessment of Ketamine-induced Cognitive Deficits in Healthy Volunteers [NCT03469089] | Phase 1 | 16 participants (Actual) | Interventional | 2018-03-12 | Active, not recruiting | ||
| Is The Pre-Emptive Administration Of Ketamine A Significant Adjunction To Intravenous Morphine Analgesia For Controlling Post-Operative Pain? A Randomized, Double Blind, Placebo Controlled Clinical Trial. [NCT03415191] | 75 participants (Actual) | Interventional | 2012-01-05 | Completed | |||
| Ketamine Versus Lidocaine Nebulization for Awake Nasal Fiberoptic Intubation: a Prospective, Randomized Double-blinded Study [NCT03414879] | Phase 4 | 60 participants (Actual) | Interventional | 2018-01-15 | Completed | ||
| Effect of Single Dose Dexmedetomidine Versus Midazolam on Emergence Agitation and Recovery Profile When Added to Ketamine for Procedural Sedation and Analgesia in Pediatric Patients Undergoing Bone Marrow Aspiration and Biopsy [NCT03647579] | 100 participants (Actual) | Interventional | 2018-08-30 | Completed | |||
| Glutamatergic Modulation to Facilitate Naltrexone Initiation: A Randomized, Controlled Trial [NCT03345173] | Phase 3 | 100 participants (Anticipated) | Interventional | 2017-11-25 | Recruiting | ||
| Psilocybin Versus Ketamine - Fast Acting Antidepressant Strategies in Treatment-resistant Depression [NCT05383313] | Phase 2 | 60 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | ||
| Perioperative Pain Alleviation of Forearm Fractures Using a Combination of Hematoma Block and Intravenous Regional Anesthesia by Ketamine and Lidocaine [NCT03377907] | 66 participants (Actual) | Interventional | 2018-02-01 | Completed | |||
| Understanding Ketamine's Dissociative Effects in Epilepsy (KD Study) [NCT04861051] | Phase 1 | 20 participants (Anticipated) | Interventional | 2021-07-26 | Recruiting | ||
| Reversal of Battle-Related Aging (ROBRA) in a Special Operations Forces Cohort [NCT05855876] | 20 participants (Anticipated) | Observational | 2023-07-05 | Recruiting | |||
| Intravenous Sub-dissociative Dose Ketamine Injection Versus Infusion for Analgesia in the Emergency Department: A Prospective, Randomized, Double-blind Placebo Controlled Trial [NCT02916927] | Phase 4 | 62 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Esketamine Combined With Pregabalin on Acute Postoperative Pain in Patients Undergoing Resection of Spinal Neoplasms. [NCT05096468] | Phase 2/Phase 3 | 90 participants (Actual) | Interventional | 2021-12-01 | Completed | ||
| Effets de la kétamine en Association Avec le Rt-PA au Cours de l'Infarctus cérébral Aigu: étude Pilote contrôlée randomisée en Double Aveugle Avec critère de Jugement Radiologique [NCT02258204] | Phase 1/Phase 2 | 50 participants (Anticipated) | Interventional | 2015-03-31 | Recruiting | ||
| Oral Ketamine for Control of Chronic Pain in Children [NCT01369680] | Phase 1 | 12 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| Ketamine and Morphine Versus Morphine Alone for the Treatment of Acute Pain in the Emergency Department [NCT01900847] | 17 participants (Actual) | Interventional | 2013-06-01 | Terminated(stopped due to concern of side effects) | |||
| Ketamine for Combined Depression and Alcohol Use Disorder: A Blinded Randomized Active Placebo-controlled Trial (the KeDA Trial) [NCT06090422] | Phase 1/Phase 2 | 34 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | ||
| Correlation Between Concentration at the Effector Site of Continuous Infusion of Ketamine (Calculated With DOMINO Pump) and Bispectral Index Values During General Anaesthesia for Breast Surgery [NCT05799729] | 40 participants (Actual) | Observational | 2023-04-01 | Completed | |||
| Hyperalgesia and NMDA Receptor Antagonist [NCT02087202] | 90 participants (Anticipated) | Interventional | 2014-03-31 | Not yet recruiting | |||
| The Effect of Opioid-Free Anesthesia in TMJ Surgery: A Prospective Study [NCT04724759] | Phase 2 | 60 participants (Anticipated) | Interventional | 2021-06-18 | Recruiting | ||
| Study of Immunomodulation Using Naltrexone and Ketamine for COVID-19 [NCT04365985] | Phase 2 | 70 participants (Actual) | Interventional | 2020-04-29 | Terminated(stopped due to Because of the decrease in COVID cases, enrollment is extremely low. Given the current study design, it is not possible to gather data necessary to answer the question about whether study treatment reduces mortality) | ||
| A Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related Pain [NCT04057989] | 80 participants (Actual) | Observational | 2014-08-31 | Completed | |||
| The Effect of Oropharyngeal Pack Soaked With Ketamine or Magnesium Sulphate on Post Operative Sore Throat After Nasal Surgeries: Randomized Controlled Double Blind Study [NCT05714540] | Phase 4 | 90 participants (Anticipated) | Interventional | 2023-02-15 | Recruiting | ||
| Comparative Study of Single Port Thoracoscopic Bullectomy Under Nonintubated Local and Sedation Anesthesia Versus Intubated General Anesthesia for Primary Spontaneous Pneumothorax. [NCT02109510] | 40 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| A Double Blinded, Randomized, Placebo Controlled, Parallel Arm Pilot Trial of Intravenous Ketamine for Emergency Department Treatment of Suicidal Ideation in a Pediatric Population [NCT05468840] | Phase 3 | 20 participants (Anticipated) | Interventional | 2023-06-30 | Not yet recruiting | ||
| Pain Management in Cardiac Implantable Electronic Device Insertion; Effectiveness of Bupivacaine, Ketorolac, Ketamine, vs Bupivacaine Alone in Reducing Postoperative Pocket Pain [NCT05575999] | Phase 1 | 200 participants (Anticipated) | Interventional | 2023-04-30 | Not yet recruiting | ||
| Cognitive Behavioral Therapy in Prolonging the Antidepressant Effects of Intravenous Ketamine [NCT02289248] | Phase 1 | 16 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Single-dose Interventions to Reduce Re-admissions for Hospitalized Patients With Refractory Alcohol Use Disorder: A Randomized Pilot Feasibility Study. [NCT04562779] | Early Phase 1 | 44 participants (Actual) | Interventional | 2021-01-19 | Completed | ||
| Pain Relief for Submucosal Resection of Nasal Septum in Adults Does Ketamine Have a Pre-Emptive Effect? [NCT02294162] | 0 participants (Actual) | Interventional | 2015-04-01 | Withdrawn(stopped due to Terminated by IRB) | |||
| Ketamine Versus Low Dose Thiopental for Rapid-sequence Induction of Anesthesia in Patients With Septic Shock [NCT03104140] | Phase 3 | 26 participants (Actual) | Interventional | 2017-04-12 | Completed | ||
| Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive Therapy ---a Randomized Control Double-Blind Clinical Trial [NCT02305394] | Phase 4 | 132 participants (Anticipated) | Interventional | 2015-01-31 | Not yet recruiting | ||
| Low-Dose Intravenous Ketamine Bolus Versus Conventional Technique for Reduction of Upper and Lower Extremity Fractures in Children: A Randomized Controlled Clinical Trial [NCT03499886] | Phase 2/Phase 3 | 198 participants (Anticipated) | Interventional | 2017-01-17 | Recruiting | ||
| Comparison of CRP Levels, Neutrophil Count, and Clinical Outcomes of Low Dose Ketamine Between at Anesthesia Induction and at the End of Surgery in Patients Undergo Elective Laparotomy [NCT04462094] | 68 participants (Actual) | Interventional | 2020-07-27 | Completed | |||
| The Effect of Ketamine Infusion for Reduction of Neuropathic Pain and Improvement of Quality of Life After Lumbar Surgery [NCT02154438] | Phase 4 | 56 participants (Anticipated) | Interventional | 2014-05-31 | Recruiting | ||
| Ketamine Infusion Therapy for the Treatment of PTSD in Paramedics [NCT03947099] | 7 participants (Actual) | Observational | 2019-05-02 | Completed | |||
| Does Subacromial Injection With Glutamate Receptor (NMDAR) Antagonist, Ketamine, Attenuate Pain in Rotator Cuff Tendinopathy? [NCT02967640] | Phase 2/Phase 3 | 20 participants (Anticipated) | Interventional | 2018-05-01 | Recruiting | ||
| A Randomized,Double Blind, Parallel Group, Placebo Controlled Dose Ranging Study to Assess the Analgesic Efficacy, Tolerability, Safety and Pharmacokinetic/Pharmacodynamic Properties of a Sublingual Wafer Formulation of Ketamine Following Third Molar Extr [NCT02199678] | Phase 2 | 120 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Comparison of the Analgesic Effect of Ketamine Versus Dexmedetomidine Added to Local Anesthetic in TAP Block for Lower Abdominal Cancer Surgery [NCT03060070] | Phase 2/Phase 3 | 90 participants (Actual) | Interventional | 2017-03-10 | Completed | ||
| Efficacy of Preventive Ketamine on Postoperative Pain: A Randomized, Double-blind Trial of Patients Undergoing Laparoscopic Sleeve Gastrectomy [NCT04908579] | Phase 4 | 90 participants (Anticipated) | Interventional | 2021-06-15 | Recruiting | ||
| Reducing Adolescent Suicide Risk: Safety, Efficacy, and Connectome Phenotypes of Intravenous Ketamine [NCT04613453] | Phase 2 | 66 participants (Anticipated) | Interventional | 2022-01-21 | Recruiting | ||
| An Open Label Study of the Effects of Ketamine on a Veteran Clinical Population With Major Depressive Disorder (MDD) [NCT03053830] | Phase 2 | 11 participants (Actual) | Interventional | 2017-01-31 | Completed | ||
| Risk Factors and Prevention of Severe Pain Upon Cessation of a Peripheral Nerve Block. A Prospective Randomized Study in Ambulatory Patients Undergoing Upper Limb Bone Surgery Under Single Shot Axillary Plexus Block [NCT04890418] | Phase 4 | 100 participants (Anticipated) | Interventional | 2020-01-01 | Recruiting | ||
| Intraoperative Low-dose Ketamine Infusion as the Main Analgesic in Burn Patients [NCT03049930] | Phase 4 | 46 participants (Anticipated) | Interventional | 2018-02-27 | Recruiting | ||
| Changes of the Short Portable Mental Status Questionnaire (SPMSQ-E) After Ketamine Administration on Ophthalmic Surgery in Geriatric Population. [NCT02049411] | Phase 2 | 80 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Management of Neuropathic Chronic Pain With Methadone Combined With Ketamine: Randomized, Double Blind, Active-controlled Clinical Trial [NCT02233452] | Phase 4 | 37 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| US Guided Interscalene Block Compared With Sedation for Shoulder Dislocation Reduction in the ER [NCT03041506] | 90 participants (Anticipated) | Interventional | 2017-02-15 | Not yet recruiting | |||
| Cognitive Biases in Decision Making in a Pharmacological Model of Psychosis : a Study in Healthy Humans Recieving Low Dose Anesthetic, Ketamine Versus Placebo [NCT02235012] | 48 participants (Anticipated) | Interventional | 2014-09-08 | Recruiting | |||
| Subject And Investigator-Blinded, Sponsor-Open, Randomized, Single-Dose, Placebo-Controlled, 2-Way, 4-Period Crossover Study To Assess Effects Of PF-02545920 On Ketamine-Induced Aberrant Prefrontal Response To Associative Learning In Healthy Subjects [NCT01244880] | Phase 1 | 4 participants (Actual) | Interventional | 2011-04-30 | Terminated(stopped due to See termination reason in detailed description.) | ||
| Comparison Between Dexmedetomidine-Propofol and Ketamine-Propofol Administration for Sedation of CT Guided Bone Biopsy: A Randomized Controlled Trial [NCT05752903] | Phase 4 | 60 participants (Actual) | Interventional | 2023-03-04 | Completed | ||
| A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders: Gdansk Depression Ketamine Project [NCT04226963] | 80 participants (Actual) | Observational [Patient Registry] | 2019-12-04 | Completed | |||
| Randomized, Double-blind Ketamine Augmentation in Chronically Suicidal, Treatment-resistant Major Depression [NCT01667926] | 37 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| Deciphering Metacognition and Treatment Response in Depression With a Novel Digital Paradigm [NCT05464264] | 30 participants (Anticipated) | Observational | 2022-10-03 | Recruiting | |||
| Increasing Retention in Methadone Maintenance Treatment: Feasibility and Preliminary Efficacy of Ketamine for the Treatment of Patients With OUD and Comorbid Depression (OUDCD) [NCT05051449] | Phase 1 | 6 participants (Anticipated) | Interventional | 2022-04-04 | Recruiting | ||
| Sedation Versus Protective Stabilization for Dental Treatment of Children With Caries and Negative Behavior at the Dentist: a Non-randomized Clinical Trial [NCT04119180] | Phase 4 | 152 participants (Anticipated) | Interventional | 2020-01-30 | Recruiting | ||
| Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant Depression: a Randomized, Double-blind Placebo-control Study [NCT05045378] | Phase 4 | 54 participants (Anticipated) | Interventional | 2022-03-15 | Recruiting | ||
| The Effects of Optimizing Post-operative Pain Management With Multi Modal Analgesia on Immune Suppression and Oncologic Outcome in Patients Undergoing Laparoscopic Colorectal Surgery [NCT03462836] | 0 participants (Actual) | Interventional | 2019-04-30 | Withdrawn(stopped due to The results of the primary endpoints of this study are expected to be difficult to identify, thus canceling the study to readjust the study plan.) | |||
| Three-level Injection Paravertebral Block Using Paravertebral Catheter Compared to General Anesthesia in Mastectomy Surgery [NCT02065947] | Phase 1/Phase 2 | 60 participants (Actual) | Interventional | 2013-10-31 | Completed | ||
| Use of Ketamine Associate With an Opioid for Sedation in ICU : a Randomized Controlled Double Blind Study [NCT01560390] | Phase 4 | 164 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| Central Versus Peripheral GABA and Glutamate Biomarkers for Treatment Response During Two Infusions of Intravenous Ketamine for Treatment-Resistant Depression [NCT03573349] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2019-01-03 | Enrolling by invitation | ||
| Methadone and Ketamine for Spinal Surgery [NCT02827526] | Phase 4 | 130 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| Long-term Pain Modulation by Intravenous Esketamine in Complex Regional Pain Syndrome: a Non-inferiority Study [NCT05212571] | 60 participants (Anticipated) | Interventional | 2022-04-19 | Enrolling by invitation | |||
| The Efficacy OF Oral DexmedetomidineVersus Oral Midazolam/Ketamine ON Parental Separation AND Face Mask Acceptance IN Pediatrics Undergoing Adenotonsillectomy [NCT03551067] | Phase 4 | 74 participants (Actual) | Interventional | 2016-08-01 | Completed | ||
| Ketamine Therapy in Obsessive-compulsive Disorder and Its Effects on Neuropsychological Function Under Stress in a Cross-over Trial [NCT05577585] | 30 participants (Anticipated) | Interventional | 2022-08-01 | Recruiting | |||
| An Analysis of Ketamine Analgesia in Third Molar Surgery -Effects, Safety and Influence on Inflammatory Biomarkers in Plasma [NCT04459377] | Phase 4 | 168 participants (Actual) | Interventional | 2017-02-14 | Completed | ||
| Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain [NCT05037123] | Phase 3 | 750 participants (Anticipated) | Interventional | 2022-01-04 | Recruiting | ||
| Impact of Sub-anesthetic Dose of Ketamine on Post Spinal Hypotension in Caesarean Delivery :Prospective , Randomized Double- Blinded Study [NCT03624166] | Phase 4 | 80 participants (Actual) | Interventional | 2019-02-01 | Completed | ||
| Neuropsychiatric and Cardiovascular Side Effects in Ketamine Analgesic Infusions: a Prospective Study [NCT03525912] | 101 participants (Actual) | Interventional | 2017-07-01 | Completed | |||
| Ketamine's Efficiency in the Treatment of Chronic Pain With an Added Inflammatory Component Exploring the Kynurenin Pathway. A Randomized, Double Blind, Placebo-controlled Trial [NCT03513822] | Phase 3 | 48 participants (Anticipated) | Interventional | 2018-02-16 | Recruiting | ||
| Evaluation of the Effects of Ketamine in the Acute Phase of Suicidal Ideation: a Multicenter Randomized Double-blind Trial [NCT02299440] | Phase 3 | 156 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| "Study Protocol OFA: Opioid-Free Anesthesia." [NCT03124082] | Phase 4 | 64 participants (Anticipated) | Interventional | 2017-01-04 | Recruiting | ||
| Retrobulbar Block Versus Ketamine Infusion as Adjuvants to General Anesthesia for Post-operative Pain Control After Enucleation [NCT03507426] | 45 participants (Actual) | Interventional | 2018-04-25 | Completed | |||
| A Randomized Double-blind Trial to Evaluate Ketamine-propofol Combination vs. Propofol Alone for Procedural Sedation and Analgesia in the Emergency Department. [NCT01211158] | Phase 3 | 284 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| Intramuscular Ketamine Versus Escitalopram and Aripiprazole in Acute and Maintenance Treatment of Patients With Treatment-resistant Depression [NCT04234776] | Phase 4 | 88 participants (Anticipated) | Interventional | 2018-04-03 | Enrolling by invitation | ||
| Low Dose Ketamine Prevent the Postoperative Cognitive Dysfunction in Aged Patients Underwent Orthopaedic Surgery，a Randomized Control Double Blinded Multicenter Clinical Trail [NCT02220400] | 484 participants (Anticipated) | Interventional | 2014-09-30 | Not yet recruiting | |||
| Turgut Ozal Medical Center Department of Anesthesiology and Reanimation [NCT02267980] | Phase 4 | 60 participants (Anticipated) | Interventional | 2014-07-31 | Recruiting | ||
| Use of Sevoflurane, Midazolam and Ketamine in Children for Dental Sedation Treatment: Occurrence of Adverse Events [NCT02284204] | Phase 2 | 27 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| A Comparison of the Sedative Effect of Ketamine and Midazolam During Spinal Anaesthesia for Elective Unilateral Inguinal Hernia Repair: A Randomized Comparative Trial [NCT03133780] | Phase 2 | 80 participants (Actual) | Interventional | 2018-07-14 | Completed | ||
| Opioid Sparing Anesthesia in Patients With Liver Cirrhosis Undergoing Liver Resection: A Controlled Randomized Double Blind Study [NCT05674877] | Phase 3 | 100 participants (Actual) | Interventional | 2022-12-01 | Completed | ||
| A Multicenter, Randomized, Double-blind Clinical Trial to Evaluate the Efficacy and Safety of BT-KTM-I Versus Ketanest® S for General Anesthesia in Elective Laparoscopic Surgery [NCT06092684] | Phase 3 | 358 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| Comparison of Ketamine Plus Dexamethasone Versus Ketamine Alone for Prevention of Severe Shivering After Spinal Anesthesia in Cesarean Section [NCT06091657] | 110 participants (Anticipated) | Interventional | 2023-10-25 | Not yet recruiting | |||
| Pragmatic Trial of Psilocybin Therapy in Palliative Care (PT2PC): A Multicenter Triple-blind Phase 2 Randomized Controlled Trial of Psilocybin Therapy for Demoralized Adults Near the End of Life [NCT05403086] | Phase 2 | 100 participants (Anticipated) | Interventional | 2024-01-14 | Not yet recruiting | ||
| A Randomized Double-Blind Controlled Trial of Ketamine Versus Placebo in Conjunction With Best Pain Management in Neuropathic Pain in Cancer Patients [NCT01316744] | Phase 3 | 214 participants (Anticipated) | Interventional | 2009-04-30 | Recruiting | ||
| Examining the Effects of Ketamine Treatment on Synaptic Plasticity in Depression Using PET Imaging [NCT04091971] | Phase 4 | 9 participants (Actual) | Interventional | 2020-10-09 | Completed | ||
| Effect of Ketamine on Intraoperative Motor Evoked Potentials [NCT06140927] | Phase 4 | 20 participants (Anticipated) | Interventional | 2023-12-01 | Not yet recruiting | ||
| Efficacity, Safety and Cost of Intravenous Morphine Titration Alone or Combined to Ketamine [NCT01146145] | 160 participants (Actual) | Interventional | 2003-05-31 | Completed | |||
| Analgo-Sedative Effects Of Oral, Or Nebulized Ketamine In Pre-schoolers Undergoing Elective Surgery: A-Comparative Randomized Double Blind Study [NCT03885427] | Early Phase 1 | 62 participants (Actual) | Interventional | 2019-03-27 | Completed | ||
| Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Trial [NCT01269307] | 99 participants (Actual) | Interventional | 2010-06-30 | Completed | |||
| The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women: Quantification of Ketamine and Metabolites [NCT04285684] | Early Phase 1 | 4 participants (Actual) | Interventional | 2019-12-20 | Completed | ||
| Low Dose Ketamine for Low Mood States: An Emergency Department Feasibility Study for Depressed Patients [NCT01209845] | Phase 1 | 14 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Analgesic Effects of Caudal S-ketamine for Supplementation of Ropivacaine Caudal Analgesia in Children With Hypospadias [NCT05922605] | Phase 4 | 44 participants (Anticipated) | Interventional | 2023-06-20 | Recruiting | ||
| A Phase I, Randomized, Double-Blind, Four-way Cross-over Study in Healthy Subjects to Assess Quantitative Electroencephalography (qEEG) Parameters After the Administration of Ketamine, Two Doses of AZD6765 and Placebo [NCT01130909] | Phase 1 | 36 participants (Actual) | Interventional | 2010-05-31 | Terminated(stopped due to The benefit of halting the study to analyze the available data outweighs the benefit of delaying the analysis to include data from remaining treatment periods) | ||
| A Comparative Study Between Spinal and General Anesthesia for Abdominoplasty. [NCT03810547] | 200 participants (Actual) | Interventional | 2017-01-30 | Completed | |||
| Immune-mediatory Response of Intravenous Ketamine Versus Propofol for Major Abdominal Surgeries: a Prospective Randomized Study [NCT03793075] | 36 participants (Anticipated) | Interventional | 2019-01-10 | Not yet recruiting | |||
| The Effect of Low Dose Nalbuphine or Ketamine in the Prevention of Emergence Agitation After Sevoflurane Anesthesia in Children Undergoing Tonsillectomy With or Without Adenoidectomy [NCT05176119] | Phase 4 | 90 participants (Actual) | Interventional | 2021-03-25 | Completed | ||
| Thoracic Epidural Analgesia: Epidural Levobupivacaine and Sufentanil Versus Epidural Levobupivacaine and Intravenous Ketamine [NCT01320475] | Phase 4 | 2 participants (Actual) | Interventional | 2010-09-30 | Terminated(stopped due to Difficulty of Recruitment) | ||
| Evaluating the Safety, Efficacy and Opiate Sparing Effects of Low-Dose, Slow Infusion Ketamine as a Battlefield Analgesic for Acute Pain in Burn Wounds. [NCT03305055] | Phase 4 | 4 participants (Actual) | Interventional | 2017-12-16 | Terminated(stopped due to Funding withdrawn - slow enrollment) | ||
| Lecturer of Anesthesia ,Intensive Care and Pain Management in Faculty of Medicine Ain Shams University [NCT03860831] | Phase 1 | 40 participants (Anticipated) | Interventional | 2019-03-06 | Recruiting | ||
| Comparing The Efficacy Of Preoperative Nebulized: Ketamine, Magnesium Sulfate, and Lidocaine In Attenuating Postoperative Sore Throat After Endotracheal Intubation [NCT03729973] | Phase 3 | 100 participants (Actual) | Interventional | 2018-11-15 | Completed | ||
| Ketamine Infusion for Treatment of Chronic Neuropathic Pain in Traumatic Brachial Plexus Injuries, a Prospective Randomized Control Study [NCT04933149] | Phase 4 | 100 participants (Anticipated) | Interventional | 2021-12-15 | Enrolling by invitation | ||
| Surgical Site Infiltration Using Ketamine Versus Bupivacaine for Analgesia in Post-operative Appendectomy Operation [NCT05097118] | Early Phase 1 | 60 participants (Actual) | Interventional | 2021-09-01 | Completed | ||
| A Randomized Controlled Trial to Evaluate the Hemodynamic Effects of Ketamine Versus Etomidate During Rapid Sequence Intubation [NCT03545503] | Phase 4 | 428 participants (Actual) | Interventional | 2018-01-01 | Completed | ||
| (2R,6R)-Hydroxynorketamine a Novel Therapeutic Analgesic for the Treatment of Neuropathic Pain: A Randomized Double Blind Cross-Over Trial. [NCT05864053] | Phase 1/Phase 2 | 25 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| A Phase 1, Randomized, Double-blind, Double-dummy, Placebo-controlled, 5-period, Crossover Study Assessing the Effects of Rapastinel Compared to Alprazolam, Ketamine, and Placebo on Simulated Driving Performance in Normal Healthy Participants [NCT03814733] | Phase 1 | 107 participants (Actual) | Interventional | 2018-11-05 | Completed | ||
| An Efficacy and Safety of Proprietary Formulations of Oral Ketamine + Aspirin and Nurtec (Rimegepant) in Adult Patients Presenting to the ED With Acute Headache: Prospective, Randomized, Open-Label, Clinical Trial [NCT04860713] | Phase 4 | 5 participants (Actual) | Interventional | 2021-04-22 | Completed | ||
| The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression. [NCT03156504] | Phase 4 | 75 participants (Actual) | Interventional | 2017-06-01 | Completed | ||
| Standardised Drug Provocation Testing in Perioperative Hypersensitivity [NCT06065137] | Phase 4 | 50 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| A PILOT STUDY OF INTRAVENOUS, SUBANESTHETIC DOSE OF KETAMINE VS PLACEBO, A CROSSOVER DESIGN, FOR MULTIPLE SCLEROSIS RELATED FATIGUE [NCT06064162] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| Optimizing Postoperative Pain Control After Laparoscopic Colorectal Surgery by Supplementing Ultrasound-guided Erector Spinae Plane Block With Ketamine or Transdermal Fentanyl Patch [NCT06007378] | 120 participants (Anticipated) | Interventional | 2023-09-05 | Recruiting | |||
| Ketamine for Treatment Resistant Late-Life Depression [NCT02556606] | Phase 3 | 33 participants (Actual) | Interventional | 2015-10-01 | Completed | ||
| Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia Using Filaments, an Algometer, and Interleukins: a Double-blind, Randomized Study [NCT01301079] | Phase 3 | 60 participants (Actual) | Interventional | 2010-09-30 | Completed | ||
| Intranasal Ketamine as an Adjunct to Fentanyl for the Prehospital Treatment of Acute Traumatic Pain [NCT02866071] | Phase 3 | 224 participants (Anticipated) | Interventional | 2017-10-03 | Active, not recruiting | ||
| Ketamine Infusion for the Treatment Chronic Pain in Adults: a Prospective Observational Study to Characterize Predictors and Outcomes [NCT05477004] | 100 participants (Anticipated) | Observational | 2022-06-01 | Enrolling by invitation | |||
| Low-dose KETamine as an Adjunct to MOrphine for Acute Pain in the ED: a Randomized, Double-blinded Clinical Trial [NCT05422001] | Phase 4 | 116 participants (Actual) | Interventional | 2022-05-31 | Terminated(stopped due to Not able to recruit opioid tolerant patients as expected) | ||
| Propofol Versus Ketamine for Procedural Sedation During Painful Procedures in the Emergency Department [NCT00997321] | Phase 4 | 100 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| Phase 4: Study of Ketamine Inhibition of Interleukin 6 in Hepatic Resections Requiring Temporary Porto-arterial Occlusion [NCT00978757] | Phase 4 | 42 participants (Actual) | Interventional | 2001-06-30 | Completed | ||
| Comparative Study Between Propofol-Ketamine Combination and Dexmedetomidine-Ketamine Combination for Sedation in Upper Gastrointestinal Endoscopy in Paediatric Patients. [NCT02863861] | Phase 4 | 120 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Combining Dexmedetomidine and Ketamine in Intensive Care Sedation: Efficacy and Safety [NCT04096768] | Phase 3 | 394 participants (Anticipated) | Interventional | 2019-09-16 | Recruiting | ||
| Comparative Effects of Dexmedetomidine and Ketofol for Sedation in Out-patients Undergoing Diagnostic Trans-esophageal Echocardiography: A Randomized Controlled Trial [NCT02867930] | Phase 4 | 50 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| A Single-Center, Single-Dose, Double-Blind, Double-Dummy, Placebo-Controlled, Randomized Crossover Study to Evaluate the Abuse Potential of Intranasal Esketamine Compared to Racemic Intravenous Ketamine in Nondependent, Recreational Users of Perception-Al [NCT02682225] | Phase 1 | 55 participants (Actual) | Interventional | 2016-03-25 | Completed | ||
| Effect of a Combination of Dexmedetomidine and Ketamine Anesthesia on Upper Airway Morphology in Children [NCT02652507] | Phase 1 | 22 participants (Anticipated) | Interventional | 2016-06-30 | Completed | ||
| Retrospective Review of Ketamine Assisted Psychotherapy Program on Mental Health at Field Trip Health Centres in North America [NCT05604794] | Phase 4 | 1,806 participants (Actual) | Interventional | 2020-03-13 | Completed | ||
| Adjunct Low Dose Ketamine Infusion Versus Standard of Care in Mechanically Ventilated Critically Ill Patients at a Tertiary Saudi Hospital: Randomized, Prospective, Pilot Trial [NCT04075006] | Phase 3 | 84 participants (Actual) | Interventional | 2019-08-28 | Completed | ||
| A Trial to Study Acute and Delayed Effects of a Single Dose of Ketamine on Functional Brain Changes During Emotional/ Cognitive Challenges and at Rest and Their Modulation by Lamotrigine in Healthy Subjects [NCT04156035] | 75 participants (Actual) | Interventional | 2020-03-10 | Completed | |||
| A Randomized, Open Label Study to Assess the Effects of a Nasal Corticosteroid on the Pharmacokinetics, Safety, and Tolerability of PMI-150 (Intranasal Ketamine Hydrochloride) 30 mg [NCT00662883] | Phase 1 | 18 participants (Actual) | Interventional | 2007-11-30 | Completed | ||
| Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot Trial [NCT05639322] | Phase 4 | 60 participants (Anticipated) | Interventional | 2023-07-15 | Not yet recruiting | ||
| Comparative Study Between Intraperitoneal Dexmedetomidine Versus Ketamine With Bupivacaine For Postoperative Analgesia After Laparoscopic Sleeve Gastrectomy [NCT04525274] | 60 participants (Actual) | Interventional | 2021-10-01 | Completed | |||
| [NCT00822133] | Phase 4 | 75 participants (Anticipated) | Interventional | 2009-02-28 | Not yet recruiting | ||
| Nasal Ketamine: Mild Sedation and Analgesia for Minor Procedures in the Pediatric Emergency Department (ED) [NCT02839928] | 20 participants (Anticipated) | Interventional | 2016-07-31 | Not yet recruiting | |||
| The Effect of Ketamine on Postoperative Cognitive Dysfunction in Geriatric Patients Undergoing Orthopaedic Surgery Under Spinal Anaesthesia, a Randomized Controlled Trial [NCT04321746] | Phase 4 | 45 participants (Actual) | Interventional | 2020-12-10 | Completed | ||
| The Effect of Intravenous Infusions of Lidocaine and Magnesium Versus Lidocaine and Ketamine Versus Lidocaine Alone on Recovery Profile and Postoperative Pain After Elective Gynecological Surgery [NCT04622904] | 90 participants (Anticipated) | Interventional | 2020-11-14 | Recruiting | |||
| Anhedonia, Development, and Emotions: Phenotyping and Therapeutics (ADEPT) Study [NCT05487885] | Phase 4 | 275 participants (Anticipated) | Interventional | 2022-07-22 | Recruiting | ||
| Pilot Study of Open Label, Intranasal Ketamine for Suicidal Ideation in Veterans [NCT03788694] | Early Phase 1 | 0 participants (Actual) | Interventional | 2020-01-01 | Withdrawn(stopped due to Study was never funded nor started, no participants were enrolled) | ||
| Ketamine as an Adjuvant Therapy for Acute Vaso Occlusive Crisis in Pediatric Patients With Sickle Cell Disease, a Pilot Study [NCT02801292] | Phase 3 | 20 participants (Anticipated) | Interventional | 2016-07-31 | Not yet recruiting | ||
| Comparing the Effect of Different Ratio of Propofol-Ketamine Mixture (Ketofol) (6:1 vs. 4:1) for Sedation in Endoscopic Retrograde Cholangiopancreatography (ERCP) [NCT04029831] | 58 participants (Actual) | Interventional | 2017-03-01 | Completed | |||
| Postpartum Depression After Cesarean Delivery: Ketamine as a Preventative Intervention: A Feasibility Pilot-study [NCT04227704] | Phase 3 | 25 participants (Actual) | Interventional | 2020-11-12 | Completed | ||
| Phase 4 THE EFFECTS OF DEXMEDETOMIDINE ON EARLY STAGE RENAL FUNCTIONS IN PEDIATRIC PATIENTS UNDERGOING CARDIAC ANGIOGRAPHY USING NON- IONIC CONTRAST MEDIA: A DOUBLE- BLIND, RANDOMIZED CLINICAL TRIAL [NCT01948336] | Phase 4 | 60 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| Caudal Ketamine-bupivacaine More Effective Than Bupivacaine-saline in Pediatric Surgical Procedures Below the Umbilicus [NCT05444036] | Phase 1 | 60 participants (Actual) | Interventional | 2018-09-01 | Completed | ||
| Physiological and Cognitive Biomarkers for Ketamine's Antidepressant Effects [NCT02669043] | 8 participants (Actual) | Interventional | 2016-07-31 | Terminated(stopped due to Funding ended.) | |||
| Prospective Analgesic Compound Efficacy (PACE) Study [NCT02403687] | 300 participants (Actual) | Observational [Patient Registry] | 2015-06-30 | Completed | |||
| Subanesthetic IV Bolus Ketamine in the Treatment of Acute Depression [NCT02378415] | Phase 1 | 20 participants (Actual) | Interventional | 2011-12-31 | Terminated(stopped due to Discrepancies in medication orders) | ||
| Ketamine Versus Dexmedetomidine for Prevention of Postoperative Delirium in Elderly Patients Undergoing Emergency Surgery: A Comparative Study. [NCT05341154] | 60 participants (Actual) | Interventional | 2021-12-01 | Completed | |||
| University of Iowa Interventional Psychiatry Service Patient Registry [NCT04480918] | 1,000 participants (Anticipated) | Observational [Patient Registry] | 2020-11-02 | Recruiting | |||
| A Phase II Study About Efficacy and Safety of the Continuous IntraVenous Infusion of Ketamine in Terminally Ill Cancer Patients With Refractory Cancer Pain [NCT03362073] | Phase 2 | 26 participants (Anticipated) | Interventional | 2018-06-01 | Recruiting | ||
| The Role of Ketamine as an Adjuvant Therapy for Children With Acute Status Asthmaticus in Pediatric Emergency Medicine Patients: A Pilot Study [NCT03338205] | Phase 3 | 20 participants (Anticipated) | Interventional | 2020-01-31 | Not yet recruiting | ||
| [NCT02493231] | Phase 4 | 60 participants (Anticipated) | Interventional | 2015-03-31 | Recruiting | ||
| Synaptic Imaging and Brain Network Activity Following Ketamine in Treatment Resistant Depression [NCT05870501] | 50 participants (Anticipated) | Interventional | 2021-10-20 | Recruiting | |||
| Comparison Between Peri Tonsillar Infiltration of Ketamine or Bupivacaine for Post Tonsillectomy Analgesia [NCT05341323] | Phase 4 | 80 participants (Actual) | Interventional | 2022-04-02 | Completed | ||
| Ketamine for Depression Relapse Prevention Following ECT: a Randomised Pilot Trial With Blood Biomarker Evaluation [NCT02414932] | Early Phase 1 | 6 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| Randomized Control Study Evaluating Ketamine as Sedative Agent in Endoscopic Retrograde Cholangiopancreatography (ERCP) [NCT04490031] | Phase 4 | 140 participants (Anticipated) | Interventional | 2020-03-01 | Recruiting | ||
| Intranasal Dexmedetomidine Versus Intranasal Midazolam-ketamine Combination for Premedication of Pediatric Patients Undergoing Strabismus Surgery [NCT02072083] | Phase 4 | 60 participants (Actual) | Interventional | 2014-02-28 | Completed | ||
| A Double-Blind, 2-Way Crossover Study to Investigate the Effects of JNJ-40411813 on Ketamine-Induced Alterations in Neuropsychiatric Performance [NCT01101659] | Phase 1 | 40 participants (Actual) | Interventional | 2010-02-28 | Completed | ||
| A Phase II Randomized, Double Blind, Placebo-Controlled Study Evaluating the Effects of Ketamine Infusions in Clinically Depressed ICU Patients [NCT05803551] | Phase 2 | 50 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| SUPER-refractory Status Epilepticus After Cardiac Arrest: a Multicenter, Retrospective, Cohort Study of Dual Anti-glutamate Therapy With Ketamine and Perampanel [NCT05756621] | 80 participants (Anticipated) | Observational | 2022-01-15 | Recruiting | |||
| Comparison of Nebulized Ketamine to Intravenous Sub-Dissociative Dose Ketamine for Treating Acute and Chronic Painful Conditions in the ED: A Prospective, Randomized, Double-Blind, Double-Dummy Clinical Trial. [NCT04947085] | Phase 4 | 150 participants (Actual) | Interventional | 2021-10-04 | Active, not recruiting | ||
| NMDAR Modulation As a Therapeutic Target and Probe of Neural Dysfunction in OCD [NCT02624596] | Phase 2 | 120 participants (Anticipated) | Interventional | 2016-06-30 | Active, not recruiting | ||
| The Effect of Intraoperative Ketamine on Opioid Consumption and Pain After Spine Surgery in Opioid-dependent Patients [NCT02085577] | Phase 4 | 147 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| Intranasal Sedation With Dexmedetomidine and Ketamine in Pediatric Dentistry (NASO II): Randomized Clinical Trial [NCT03290625] | Phase 4 | 12 participants (Actual) | Interventional | 2017-11-09 | Completed | ||
| Exploring the Safety and Efficacy of Low-dose Ketamine Infusions for Pain Control in Acute Burn Injury [NCT03095222] | Phase 4 | 0 participants (Actual) | Interventional | 2017-04-01 | Withdrawn(stopped due to The study never screened or enrolled any subjects due to stalled recruitment efforts.) | ||
| Second Affiliated Hospital Zhejiang University School of Medicine [NCT05016128] | 92 participants (Anticipated) | Interventional | 2021-08-17 | Recruiting | |||
| A Prospective, Multi-center, Randomized Controlled Study of Neuromuscular Blocking Effect and Safety of Mivacurium Chloride in Pediatric Patients [NCT02117401] | Phase 4 | 1,152 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| A Randomized Comparison of Ketamine and Methohexital Anesthesia for Electroconvulsive Therapy (ECT) in Depression [NCT01367119] | 38 participants (Actual) | Interventional | 2011-05-31 | Completed | |||
| A Phase 2A Open-Label Study Evaluating the Safety and Efficacy of Low-Dose Ketamine in Children With ADNP Syndrome [NCT04388774] | Phase 1/Phase 2 | 10 participants (Actual) | Interventional | 2020-08-19 | Completed | ||
| An Open Prospective Trial of IV Ketamine in Suicidal Adolescents [NCT02048423] | Phase 2/Phase 3 | 10 participants (Anticipated) | Interventional | 2013-06-30 | Recruiting | ||
| Examining The Effect Of Ketamine On Glutamate/Glutamine Cycling [NCT02037035] | Early Phase 1 | 36 participants (Actual) | Interventional | 2013-07-31 | Completed | ||
| Effects of Ketamine Treatment on Suicidal Ideation, Drug-resistant Major Depression, and Negative Emotional Experience. Clinical and fMRI Study [NCT02037503] | Phase 3 | 100 participants (Anticipated) | Interventional | 2014-01-31 | Recruiting | ||
| Fentanyl vs. Lidocaine/Ketamine Infusion for Hip Arthroscopy [NCT02150161] | Phase 3 | 53 participants (Actual) | Interventional | 2014-05-31 | Terminated(stopped due to DSMB estimated futility of the trial and safety risk) | ||
| Efficacy, Safety and Cost-effectiveness of Intranasal Sedation With Ketamine and Midazolam in Pediatric Dentistry: a Randomized Clinical Trial [NCT02447289] | Phase 4 | 84 participants (Actual) | Interventional | 2015-05-21 | Completed | ||
| Comparison Between Efficacy of Ketamine and Propofol Mixture With 1:6 Ratio and 1:4 Ratio for Endoscopic Retrograde Procedure Sedation [NCT03196479] | 58 participants (Actual) | Interventional | 2017-03-01 | Completed | |||
| Phase 2, Controlled, Single-Blind, 3-Month Extension Study For Participants Originally Diagnosed With Treatment Resistant Major Depressive Disorder (TRD) Who Complete Study ZYL-730-01 With, or Without, Almond Therapy [NCT05438758] | Phase 2 | 0 participants (Actual) | Interventional | 2023-01-15 | Withdrawn(stopped due to Withdrawn by Sponsor) | ||
| Dexmedetomidine-ketamine Versus Propofol-ketamine for Sedation During Upper Gastro-intestinal Endoscopy in Hepatic Patients (a Comparative Randomized Study) [NCT04906772] | Phase 4 | 70 participants (Anticipated) | Interventional | 2021-02-03 | Active, not recruiting | ||
| A Double Blinded Randomized Trial of Ketamine Versus Haloperidol for Severe Prehospital Agitation [NCT02103881] | Phase 4 | 0 participants (Actual) | Interventional | 2014-04-30 | Withdrawn | ||
| Ketamine Versus Midazolam for Prehospital Agitation [NCT03554915] | 314 participants (Actual) | Observational | 2017-08-01 | Completed | |||
| KET-MCI: An Open-label Trial of Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive Impairment [NCT06069843] | Phase 2 | 15 participants (Anticipated) | Interventional | 2023-10-18 | Recruiting | ||
| Study of Comparison of the Effectiveness of Three Diagrams for Sedation in Spinal Anesthesia [NCT02136641] | Phase 4 | 75 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| Translational Biomarkers of Fast Acting Therapies in Major Depression [NCT02165449] | Phase 1 | 60 participants (Actual) | Interventional | 2014-06-30 | Completed | ||
| Ketamine + Cognitive Training for Suicidality in the Medical Setting: Pilot [NCT04154150] | Phase 4 | 16 participants (Actual) | Interventional | 2019-12-19 | Terminated(stopped due to Midway through this pilot study, funding was obtained to support a much larger study of the same interventions in this clinical population. Therefore the pilot study was halted so as not to compete with enrollment for the larger study.) | ||
| Safety and Efficacy of Dexmedetomidine vs Ketamine vs Midazolam Combined With Propofol in Gastrointestinal Procedures for Cancer Patients [NCT04597268] | 75 participants (Actual) | Interventional | 2020-11-01 | Completed | |||
| PCA Ketamine-Morphine Versus PCA Morphine as Post-Operative Analgesia in Colorectal Surgery. [NCT06010056] | Phase 4 | 60 participants (Actual) | Interventional | 2018-04-05 | Completed | ||
| Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression [NCT05450432] | Phase 4 | 100 participants (Anticipated) | Interventional | 2022-10-13 | Recruiting | ||
| Analgesic Efficacy and Pharmacokinetic-pharmacodynamic Relationship of Intranasally Administered Sufentanil, Ketamine, and CT001 After Impacted Mandibular Third Molar Extraction - A Double-blind, Randomised, Placebo-controlled Study [NCT05508594] | Phase 2/Phase 3 | 220 participants (Actual) | Interventional | 2022-09-05 | Completed | ||
| The Effects of Sedatives on Tobacco Use Disorder Version 2 [NCT05505630] | Early Phase 1 | 52 participants (Anticipated) | Interventional | 2023-01-31 | Recruiting | ||
| A Prospective, Single Center, Double Blind, Randomized, Crossover Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic Cancer [NCT05086250] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2022-10-20 | Recruiting | ||
| Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease [NCT01326325] | Phase 3 | 24 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| A Pilot Study to Assess the Efficacy of Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy [NCT05019885] | Phase 2 | 6 participants (Anticipated) | Interventional | 2022-08-26 | Recruiting | ||
| Randomised Double Blind Comparison of Prophylactic Tramadol and Tramadol Plus Ketamine for Prevention of Shivering After Spinal Anesthesia in Lower Segment Caeserian Section [NCT06134895] | Phase 4 | 190 participants (Anticipated) | Interventional | 2023-08-16 | Recruiting | ||
| A Multi-Center, Phase II, Randomized, Double-Blind, Prospective, Active Placebo- Controlled Trial of Sub-Anesthetic Intravenous Infusion of Ketamine to Treat Levodopa- Induced Dyskinesia in Subjects With Parkinson's Disease [NCT04912115] | Phase 2 | 30 participants (Actual) | Interventional | 2021-10-05 | Suspended(stopped due to Seeking Pivotal study initiation) | ||
| The Neurobiology of Suicide [NCT02543983] | Phase 2 | 325 participants (Anticipated) | Interventional | 2015-12-01 | Recruiting | ||
| Implications of Different Analgesic Models on Inflammatory Markers After Laparoscopic Cholecystectomy [NCT04609033] | 110 participants (Actual) | Interventional | 2020-10-24 | Completed | |||
| Evaluation of the Analgesic Effect of Orally Administrated Ketamine in Peripheral Neuropathic Pain Disease: Comparison of Three Doses Versus Placebo. [NCT00961194] | Phase 2 | 22 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| PERIOPERATIVE EFFECTS OF ORAL DEXMEDETOMIDINE, KETAMINE, OR MIDAZOLAM PREMEDICATION IN CHILDREN UNDERGOING ADENOTONSILLECTOMY [NCT05874245] | Phase 4 | 222 participants (Anticipated) | Interventional | 2023-03-01 | Recruiting | ||
| A Randomized Active Placebo Controlled Trial of Ketamine in Borderline Personality Disorder [NCT03395314] | Phase 2 | 22 participants (Actual) | Interventional | 2018-02-15 | Terminated(stopped due to assessment of project in wake of covid-19 related interruptions) | ||
| [NCT01017393] | 209 participants (Actual) | Interventional | 2004-04-30 | Completed | |||
| The Application of Ketamine for Sedation in Patients With Cardiac Arrest: Feasibility, Safety, and Potential Impact on Neurological Outcomes [NCT04360070] | 24 participants (Anticipated) | Interventional | 2022-02-28 | Recruiting | |||
| Topical Amitriptyline, Ketamine and Lidocaine in Neuropathic Pain Caused by Radiation Skin Reaction: a Pilot Study [NCT00798083] | Phase 3 | 22 participants (Anticipated) | Interventional | 2008-04-30 | Completed | ||
| [NCT00822419] | Phase 4 | 75 participants (Anticipated) | Interventional | 2009-02-28 | Not yet recruiting | ||
| Premedication for Less Invasive Surfactant Administration [NCT03735563] | Phase 4 | 40 participants (Anticipated) | Interventional | 2019-02-11 | Recruiting | ||
| Prevention of NMDA Antagonist-induced Psychosis and Memory Impairment in Children [NCT00205712] | Phase 4 | 40 participants (Actual) | Interventional | 2003-02-28 | Completed | ||
| Ketamine Therapy Among Patients With Treatment-resistant Depression: a Randomised, Double-blind, Placebo-controlled Trial: Pilot Phase [NCT02401139] | Phase 1 | 10 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| An Open Label, Two-way Crossover Study to Evaluate the PK Effects of Two Different Wafer Administration Protocols in Healthy Volunteers Under Fasted Conditions. [NCT02857361] | Phase 2 | 10 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| A Randomized, Double-Blind, Parallel Group, Placebo-Controlled, Dose Ranging Study to Assess the Analgesic Efficacy, Tolerability, Safety and Pharmacokinetic/Pharmacodynamic Properties of A Sublingual Wafer Formulation of Ketamine Following Third Molar Ex [NCT02356965] | Phase 2 | 80 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| Ketamine and Mindfulness Based Cognitive Therapy (MBCT) in Treatment of Post-Traumatic Stress Disorder (PTSD): Comparison of Treatment Efficacy and Metabolomic Profiles [NCT02766192] | 50 participants (Anticipated) | Interventional | 2013-08-31 | Recruiting | |||
| Randomized Controlled Trial of Oral Sedatives for Moderate Sedation in Young Children [NCT00902395] | Phase 4 | 41 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| The Effect of Intravenous Ketamine on Non-suicidal Self-injuries in Women Suffering From Complex Post Traumatic Stress Disorder (cPTSD) [NCT04242914] | Phase 1/Phase 2 | 30 participants (Anticipated) | Interventional | 2019-02-25 | Recruiting | ||
| Ketamine vs Propofol for Sedation During Pediatric Bronchoscopy [NCT02743104] | 150 participants (Anticipated) | Interventional | 2016-05-31 | Suspended(stopped due to Protocol being reconsidered) | |||
| Reward Emotion Learning and Ketamine Study [NCT04850911] | 70 participants (Anticipated) | Interventional | 2021-08-25 | Recruiting | |||
| Effect of Ketamine on Laboratory-induced Stress in Healthy Subjects: A Proof-of-Concept Translational Study [NCT04173962] | Phase 2 | 24 participants (Actual) | Interventional | 2019-08-08 | Completed | ||
| The Effects of Sevoflurane or Ketamine on QTc Interval During Electroconvulsive Therapy [NCT01870219] | Phase 4 | 24 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Topical Ketamine by Neubulization Method in Tonsillectomy [NCT02720406] | Phase 2/Phase 3 | 100 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| A Retrospective Chart Review of Patients Undergoing Ketamine Infusions at the Canadian Rapid Treatment Center of Excellence [NCT04209296] | 580 participants (Anticipated) | Observational | 2019-12-03 | Enrolling by invitation | |||
| A Phase 2, Factorial-Designed, Randomized, Double-Blind, Placebo-Controlled, Parallel- Cohort Study to Evaluate Efficacy and Safety of MELT-300 and the Contribution of Midazolam and Ketamine Components to Sedation and Intraoperative Ocular Analgesia in Su [NCT05133518] | Phase 2 | 338 participants (Actual) | Interventional | 2021-07-20 | Completed | ||
| Positron Emission Tomography Assessment of Ketamine Binding of the Serotonin Transporter and Its Relevance for Rapid Antidepressant Response [NCT02717052] | Phase 2 | 74 participants (Anticipated) | Interventional | 2016-05-31 | Recruiting | ||
| Proof of Concept Study for Evaluation of the Effect of Ketamine Intranasal Spray in Treatment of Chronic Cluster Headache [NCT04179266] | Phase 1/Phase 2 | 23 participants (Actual) | Interventional | 2019-11-20 | Completed | ||
| Ketamine vs. Methohexital Anesthesia for Improvement of Major Depressive Disorder in Electroconvulsive Therapy [NCT02752724] | 52 participants (Actual) | Interventional | 2016-03-31 | Completed | |||
| Prehospital Analgesia With Intra-Nasal Ketamine [NCT02753114] | Phase 4 | 120 participants (Actual) | Interventional | 2017-11-06 | Completed | ||
| EFFECT OF LOW DOSE INTRAVENOUS KETAMINE ON POSTOPERATIVE COGNITIVE FUNCTIONS [NCT05323422] | 120 participants (Anticipated) | Observational [Patient Registry] | 2022-04-12 | Not yet recruiting | |||
| A Comparison of the Sedation With Intermittent Bolus Midazolam-Ketamine Versus Intermittent Bolus Propofol-Fentanyl During Endoscopy in Children: Randomized Trial [NCT02732132] | Phase 4 | 238 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Effects of Intrathecally Administered Ketamine, Morphine and Their Combination in Patients Undergoing Major Abdominal Cancer Surgery [NCT02726828] | Phase 2/Phase 3 | 90 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| Intra-nasal vs. Intra-venous Ketamine Administration as an add-on to Antidepressant Therapy [NCT02644629] | Phase 4 | 45 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| A Double-blind Randomised, Placebo-controlled Study of Adjunctive Ketamine Anaesthesia in ECT (Electroconvulsive Therapy) [NCT00680433] | Phase 4 | 83 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| Pilot Study of ORG 25935 Modulation of Ketamine-induced Behavioral and Cognitive Effects in Healthy Male Subjects [NCT00700076] | Phase 1 | 15 participants (Actual) | Interventional | 2008-01-22 | Completed | ||
| A Randomized Control Trial Employing fMRI to Investigate the Effects of Ketamine on Mentalizing and Metacognition in Healthy Volunteers [NCT05320991] | Phase 4 | 70 participants (Actual) | Interventional | 2019-06-15 | Completed | ||
| Pupillary Diameter Variation After Standardized Tetanic Stimulations of Incremental Intensities in Patients Under Ketamine Sedation [NCT02648412] | 24 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| Intranasal Ketamine With Dexmedetomidine for the Treatment of Children With Autism Spectrum Disorder [NCT03434366] | Phase 2 | 50 participants (Anticipated) | Interventional | 2018-01-20 | Suspended(stopped due to The effects are not good) | ||
| A Randomized, Double-blind Study of Ketamine / Dexmedetomidine vs. Placebo / Dexmedetomidine as Adjunctive Therapies for Severe Alcohol Withdrawal [NCT02823977] | Phase 4 | 0 participants (Actual) | Interventional | 2018-02-28 | Withdrawn(stopped due to Funding not obtained) | ||
| Inonu University Faculty of Medicine Department of Anesthesiology and Reanimation [NCT02819375] | Phase 4 | 45 participants (Actual) | Interventional | 2017-01-31 | Completed | ||
| Randomized Triple-blind Placebo Controlled Trial of Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival and Neurological Outcome [NCT04009759] | Phase 1 | 240 participants (Anticipated) | Interventional | 2021-10-01 | Not yet recruiting | ||
| Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine [NCT05327699] | Early Phase 1 | 250 participants (Anticipated) | Interventional | 2022-11-08 | Recruiting | ||
| Ketamine-propofol Versus Pethidine-propofol for Sedating Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP) [NCT02651792] | Phase 2 | 50 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Remifentanil Requirement for Acceptable Intubating Condition With Two Dose Ketamine Without Neuromuscular Blocking Agent in Children [NCT02655380] | Phase 4 | 51 participants (Actual) | Interventional | 2017-06-19 | Completed | ||
| A Prospective, Randomized, Double-Blind, Controlled Trial Evaluating the Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis [NCT02651324] | Phase 4 | 50 participants (Anticipated) | Interventional | 2013-05-31 | Active, not recruiting | ||
| Different Modalities of Analgesia in Open Heart Surgeries in Mansoura University: Randomized Prospective Comparative Study [NCT04223219] | Phase 4 | 90 participants (Actual) | Interventional | 2019-12-10 | Active, not recruiting | ||
| Efficacy and Safety of Repeated Intravenous Subanesthetic Ketamine Infusions Among Veterans With Treatment Resistant Depression Comorbid With Chronic Post-Traumatic Stress Disorder: A Proof-of-concept Study [NCT02577250] | Phase 1 | 20 participants (Anticipated) | Interventional | 2015-05-31 | Completed | ||
| Single Bolus Dose of Ketodex Versus Ketofol For Prevention Of Emergence Agitation In Adults Undergoing Nasal Surgeries [NCT04018157] | Early Phase 1 | 150 participants (Actual) | Interventional | 2019-07-03 | Completed | ||
| N-methyl-D-aspartate Antagonist (Ketamine) Infusion for Treatment-resistant Major Depressive Disorder With Suicidal Ideation [NCT01582945] | 14 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| Acute Analgesic Effects of DMT on Experimentally Induced Acute Nociceptive Pain, Hyperalgesia and Allodynia in Healthy Participants [NCT06180759] | Phase 1 | 18 participants (Anticipated) | Interventional | 2024-05-01 | Not yet recruiting | ||
| Effect of Ketamine and Etomidate During Rapid Sequence Intubation on Long- Term Outcomes (Long-Term Outcomes of the RSI Trial) [NCT06179485] | 1,756 participants (Anticipated) | Observational | 2022-04-06 | Recruiting | |||
| Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder [NCT03065335] | Phase 1 | 150 participants (Anticipated) | Interventional | 2017-05-25 | Recruiting | ||
| Effects of Ketamine 0.5 Mg/Kgbw Administration as Preemptive Analgesia on Analgesia Duration and the Need for Fentanyl Following Hysterectomy Surgery [NCT06040060] | Phase 2/Phase 3 | 40 participants (Actual) | Interventional | 2022-12-27 | Completed | ||
| Posttraumatic Stress Disorder (PTSD) Treatment: Using Ketamine to Enhance Memory Reconsolidation and Extinction of Overgeneralized Fear in Individuals Diagnosed With PTSD [NCT05737693] | Phase 2 | 162 participants (Anticipated) | Interventional | 2023-08-21 | Recruiting | ||
| S-ketamine for Cortical Spreading Depolarisation in Patients With Severe Acute Brain Injury [NCT05095857] | Phase 4 | 400 participants (Anticipated) | Interventional | 2023-09-15 | Recruiting | ||
| Dexmedetomidine Versus Ketamine to Prevent Shivering Associated With Intrathecal Anesthesia in Patients Undergoing Knee Arthroscopy:A Randomized, Controlled Double Blinded Study. [NCT06082076] | Phase 2/Phase 3 | 90 participants (Anticipated) | Interventional | 2023-11-30 | Not yet recruiting | ||
| Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response [NCT03367533] | Phase 1 | 13 participants (Actual) | Interventional | 2018-11-29 | Completed | ||
| Evaluation of Schemes of Administration of Intravenous Ketamine in Treatment-resistant Depression: Clinical-neuroimaging Correlation [NCT03742557] | Phase 3 | 30 participants (Anticipated) | Interventional | 2018-10-01 | Recruiting | ||
| Cognitive Recovery After Electroconvulsive Therapy and General Anesthesia Reconstitution of Consciousness and Cognition (Phase 2) [NCT02761330] | 17 participants (Actual) | Interventional | 2016-04-30 | Completed | |||
| The Role of HNKs in the Antidepressant Effect of Ketamine [NCT03977675] | Phase 1 | 8 participants (Actual) | Interventional | 2019-05-15 | Terminated(stopped due to PI left the institution) | ||
| Nicotinic Modulation of (NMDA) Receptor Antagonist Schizophrenia-like Information Processing Deficits in Humans [NCT00690170] | Phase 1 | 30 participants (Actual) | Interventional | 2002-12-31 | Completed | ||
| Role Of Ketamine in Treatment-Resistant Major Depressive Disorder And Its Effect on Suicidality [NCT04101474] | Early Phase 1 | 30 participants (Anticipated) | Interventional | 2019-12-01 | Not yet recruiting | ||
| The Effectiveness of Small Doses of Ketamine With Morphine on Decreasing Pain Responses During Open Wound Care [NCT00701909] | Phase 3 | 12 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| Ambulatory Infusions of Lidocaine and Ketamine for Management of Chronic Pain: an Observational Prospective Study [NCT04123652] | Phase 4 | 162 participants (Actual) | Interventional | 2017-11-05 | Completed | ||
| A Randomized Controlled Non-inferiority Trial Comparing Ketamine With ECT in Patients With Major Depressive Disorder [NCT02659085] | Phase 2/Phase 3 | 198 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries: A Randomized Clinical Trial [NCT03470675] | Phase 4 | 67 participants (Actual) | Interventional | 2018-06-27 | Active, not recruiting | ||
| Repeated Ketamine Treatment to Accelerate Efficacy of Prolonged Exposure in PTSD [NCT04560660] | Phase 2 | 100 participants (Anticipated) | Interventional | 2021-03-09 | Recruiting | ||
| Comparing the Hemodynamic Effects of Bolus of Ketamine and Fentanyl in Patients With Septic Shock: a Randomized Controlled Trial [NCT05957302] | 86 participants (Actual) | Interventional | 2023-08-01 | Completed | |||
| Procedural Sedation for Painful Orthopedic Manipulations With Propofol vs. Midazolam/Ketamine in the Adult Emergency Department [NCT00784498] | Phase 4 | 60 participants (Anticipated) | Interventional | 2008-11-30 | Completed | ||
| Effects of Perioperative Lidocaine and Ketamine Infusions on Acute Functional Recovery After Abdominal Hysterectomy [NCT00721110] | 64 participants (Actual) | Interventional | 2008-07-31 | Terminated(stopped due to Futility) | |||
| Propofol-Ketamine vs Remifentanyl-Ketamine for Sedation in Pediatric Patients Undergoing Colonoscopy [NCT02602743] | Phase 4 | 70 participants (Actual) | Interventional | 2016-08-31 | Completed | ||
| Evaluation of the Effect of Adding Magnesium Sulfate Infusion to Ketamine Infusion on Improvement of the Analgesic Efficacy in Cancer Breast Surgeries. [NCT04111848] | Phase 4 | 90 participants (Actual) | Interventional | 2019-11-01 | Completed | ||
| Ketamine and Hydromorphone PCA Analgesia for Antineoplastic-Induced Pediatric Mucositis [NCT00474110] | Phase 3 | 0 participants (Actual) | Interventional | 2009-08-31 | Withdrawn(stopped due to Clinical practice had changed between time of initial protocol development and subject recruitment. We were not able to find eligible patients.) | ||
| Ketamine Interleaved With Electroconvulsive Therapy for Depression, A Pragmatic Randomised Controlled Pilot Trial [NCT04082858] | Phase 1 | 3 participants (Actual) | Interventional | 2020-01-06 | Terminated(stopped due to Inadequate recruitment due to COVID-19) | ||
| The Effect and Tolerance of a Ketamine Subcutaneous Bolus, During Painful Care of Refractory Bed Sores, Ulcers and Vascular Wounds in a Palliative Care Unit [NCT02587130] | Phase 4 | 8 participants (Actual) | Interventional | 2016-05-31 | Terminated(stopped due to difficulted recruiting) | ||
| Phase I Trial to Determine Steady State Pharmacokinetics and Sedative Effects of Low Dose Ketamine Infusion [NCT00618397] | Phase 1 | 5 participants (Actual) | Interventional | 2006-06-30 | Terminated(stopped due to Poor recruitement) | ||
| Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy [NCT02579642] | Phase 4 | 48 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| Low Dose Perioperative Ketamine Infusion and it's Effect on Postoperative Pain Score, Sedation Score and Narcotic Consumption in Patients Undergoing Spine Surgery: A Prospective Randomized Double Blind Control Trial. [NCT04259476] | Phase 1 | 60 participants (Anticipated) | Interventional | 2020-01-01 | Recruiting | ||
| Ketamine Frequency Treatment for Major Depressive Disorder [NCT00646087] | Phase 4 | 0 participants (Actual) | Interventional | 2008-03-31 | Withdrawn(stopped due to Pilot study determined that this study would not be feasible.) | ||
| Comparison of Sub-dissociative Intranasal Ketamine Plus Standard Pain Therapy Versus Standard Pain Therapy in the Treatment of Pediatric Sickle Cell Disease Vasoocclusive Crises in Resource-limited Settings: a Multi-centered, Randomized, Controlled Trial [NCT02573714] | 160 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | |||
| Randomized, Multiple-center, Double-blind, Placebo-controlled Study of the Safety and Analgesic Efficacy of Repeated Dosing of PMI-150 (Intranasal Ketamine) to Treat Acute Post-operative Pain Following Orthopedic Trauma, Injury, or Surgery. [NCT00709436] | Phase 3 | 250 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| Neurophysiological Effect of Ketamine in Patients With Severe Traumatic Brain Injury [NCT06062628] | Early Phase 1 | 10 participants (Anticipated) | Interventional | 2023-11-30 | Not yet recruiting | ||
| Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone [NCT01594047] | 113 participants (Actual) | Interventional | 2009-12-01 | Completed | |||
| Effects of Esketamine Pre-administration on Blood Lymphocyte Subsets and Inflammatory Factors in Early Postoperative Period: [NCT05180318] | Phase 4 | 100 participants (Anticipated) | Interventional | 2023-12-01 | Not yet recruiting | ||
| Impact of Ketamine On Depressive Symptoms In Patients Undergoing Lumbo-peritoneal Shunt Insertion. A Randomized Double-blind Controlled Trial. [NCT06060210] | Phase 4 | 60 participants (Anticipated) | Interventional | 2023-09-29 | Recruiting | ||
| The Randomized Trial of Sedative Choice for Intubation [NCT05277896] | Phase 4 | 2,364 participants (Anticipated) | Interventional | 2022-04-06 | Recruiting | ||
| Opiate Suicide Study in Patients With Major Depression [NCT04116528] | Phase 3 | 60 participants (Anticipated) | Interventional | 2020-08-01 | Recruiting | ||
| Comparative Evaluation The Effect of Intraoperative Infusion of Dexmedetomidine Versus Low Dose Ketamine on Pain and Inflammatory Biomarkers in Patients Undergoing Nasal Surgery [NCT05828199] | Phase 1 | 80 participants (Anticipated) | Interventional | 2022-12-01 | Recruiting | ||
| A Randomized, Double Blind, Feasibility Study of Oral Ketamine Versus Placebo for Treating Depression in Patients With Cancer [NCT02836288] | Early Phase 1 | 4 participants (Actual) | Interventional | 2016-12-20 | Completed | ||
| Diabetic Neuropathic Pain Topical Treatment- Comparative Study [NCT00661063] | Phase 3 | 200 participants (Anticipated) | Interventional | 2008-04-30 | Not yet recruiting | ||
| Perioperative Multimodal General Anesthesia Focusing on Specific CNS Targets in Patients Undergoing Cardiac Surgeries [NCT04016740] | Early Phase 1 | 22 participants (Actual) | Interventional | 2019-08-20 | Completed | ||
| The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6) [NCT02624401] | Phase 4 | 160 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of Intravenous PCN-101 in Treatment Resistant Depression [NCT05414422] | Phase 2 | 102 participants (Actual) | Interventional | 2022-02-01 | Completed | ||
| Comparison of Effects on Hemodynamics Between Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients With High Shock Index [NCT04120870] | 10 participants (Actual) | Interventional | 2019-10-01 | Terminated(stopped due to Due to difficulties in obtaining consent because of emergency situation) | |||
| Effectiveness of Ketamine Treatment in Difficult-to-treat Depression Comparing With Midazolam: a Double-blind Randomized Controlled Trial and Its Cost Effectiveness Analysis [NCT05026203] | Phase 4 | 24 participants (Anticipated) | Interventional | 2021-09-01 | Recruiting | ||
| Effect of Ketamine on Opioid-Induced Hyperalgesia [NCT00833755] | 79 participants (Actual) | Interventional | 2008-09-30 | Completed | |||
| Ketamine for Acute Pain After Trauma: KAPT Trial [NCT04129086] | Phase 4 | 305 participants (Actual) | Interventional | 2020-07-01 | Completed | ||
| Comparison of the Perioperative Effects of Dexmedetomidine and Ketamine Sedation in Septorhinoplasty Operations [NCT04628559] | 63 participants (Actual) | Interventional | 2009-07-01 | Completed | |||
| Ketamine as the Main Analgesic Agent During Analgesia-based Sedation for Elective Colonoscopy- a Randomised, Double-blind, Control Study [NCT05421962] | Phase 1 | 90 participants (Actual) | Interventional | 2020-01-01 | Completed | ||
| A Randomized, Double-blind, Placebo-controlled, Study to Identify the Opioid-sparing Effects, and Pain-reduction Potential of Low Dose Ketamine on Patients Undergoing TEVAR Procedures Receiving NCI [NCT04600089] | Phase 2 | 20 participants (Anticipated) | Interventional | 2020-12-08 | Recruiting | ||
| [NCT01386229] | Phase 4 | 40 participants (Anticipated) | Interventional | 2011-03-31 | Recruiting | ||
| Effect of Ketamine Added to Intravenous Patient-controlled Analgesia on Postoperative Pain, Nausea and Vomiting in Patients Undergoing Lumbar Spinal Surgery [NCT01394406] | Phase 4 | 50 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| Brain Network Dysfunction as a Model for Schizophrenia: Connectivity Alterations Using Ketamine and Pharmacological Magnetic Resonance Imaging [NCT01394757] | 52 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy: A Randomized Controlled Trial [NCT05597878] | Phase 2/Phase 3 | 100 participants (Anticipated) | Interventional | 2023-04-18 | Recruiting | ||
| The Use of S Ketamine Versus Placebo During Target Controlled Intravenous Anaesthesia to Reduce Morphine Consumption and Side-Effects After Abdominal Hysterectomy: A Randomized Control Trial [NCT02543385] | 0 participants (Actual) | Interventional | 2014-06-30 | Withdrawn(stopped due to Change of protocol title) | |||
| The Neurophysiological Effects of Intravenous Alcohol as Potential Biomarkers of Ketamine's Rapid Antidepressant Effects in Major Depressive Disorder [NCT02122562] | Phase 2 | 60 participants (Anticipated) | Interventional | 2014-04-23 | Recruiting | ||
| Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus [NCT03336398] | Phase 2 | 42 participants (Actual) | Interventional | 2019-09-01 | Active, not recruiting | ||
| The Effect of Opioid Free Anesthesia on the Postoperative Opioid Consumption in Laparoscopic Bariatric Surgeries: Randomized Controlled Study [NCT04048200] | Phase 4 | 90 participants (Actual) | Interventional | 2019-09-01 | Completed | ||
| Effect of Regional Anesthesia and Sedation With Ketamine Versus Regional Anesthesia and Sedation With Midazolam in Cognitive Function in Patients Over 60 Years of Age in Elective Surgery at 3 Months of Postoperative Follow-up [NCT04134052] | Phase 3 | 68 participants (Anticipated) | Interventional | 2021-01-24 | Recruiting | ||
| "Haemodynamic Stability of Ketamine / Propofol Admixture Ketofol in Patient Undergoing Endoscopic Retrograde Cholangio Pancreatography" [NCT02618668] | Phase 2 | 90 participants (Actual) | Interventional | 2015-07-31 | Terminated | ||
| Low Dose Ketamine for Acute Management of Mood Disorders With Suicidal Ideation [NCT04099771] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2019-07-01 | Recruiting | ||
| Intranasal Ketamine for Acute Traumatic Pain in the Emergency Department: A Prospective, Randomized Clinical Trial of Efficacy and Safety [NCT02817477] | Phase 4 | 90 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| Clinical Trial of the Use of Ketamine in Treatment Resistant Depression [NCT02610712] | Phase 4 | 20 participants (Anticipated) | Interventional | 2014-05-31 | Recruiting | ||
| Cardiovascular and Neuropsychiatric Side Effects in Ketamine Analgesic Infusions in Acute Pain [NCT03979105] | 300 participants (Actual) | Observational | 2017-07-01 | Completed | |||
| The CHECK Trial: A Comparison of Headache Treatment in the Emergency Department: Compazine Versus Ketamine. A Multi-Center, Randomized, Double-Blind, Clinical Control Trial [NCT02735343] | Phase 3 | 5 participants (Actual) | Interventional | 2016-08-31 | Terminated(stopped due to only recruited 5 patients at this location) | ||
| Evaluation of PK/PD, Breastmilk Transfer, and Effectiveness of Ketamine After Cesarean Delivery - Part 1 [NCT04037085] | Phase 2 | 8 participants (Actual) | Interventional | 2019-10-09 | Completed | ||
| NMDA Dysregulation in Individuals With a Family Vulnerability to Alcoholism [NCT00588952] | 99 participants (Actual) | Interventional | 2001-03-31 | Completed | |||
| Comparison of Oral Morphine Versus Nasal Ketamine Spray With Chitosan in Cancer Pain Outpatients [NCT02591017] | Phase 3 | 11 participants (Actual) | Interventional | 2015-02-28 | Terminated(stopped due to insufficient enrollment) | ||
| Opioid Free Anaesthesia vs Opioid Based Anesthesia in Cleft Lip, Palate ,Alveolus Surgery. [NCT04081909] | Phase 4 | 60 participants (Anticipated) | Interventional | 2019-09-04 | Not yet recruiting | ||
| Intravenous Subdissociative-dose Ketamine Versus Morphine for Prehospital Analgesia a Randomized Controlled Trial [NCT03236805] | Phase 3 | 285 participants (Actual) | Interventional | 2017-11-23 | Terminated(stopped due to 285 patients have recruited instead on 496 but we don't want to continue to prolonge the study. Analysis will be performed on the data we have.) | ||
| The Effect Of Ultrasound-guided Modified Pectoral Nerves Block Versus Ketamine Plus Magnesium Infusion On Perioperative Analgesic Profile In Major Breast Cancer Surgeries: Randomized Controlled Study [NCT04095455] | Phase 3 | 75 participants (Anticipated) | Interventional | 2017-11-12 | Recruiting | ||
| Can Digital Health Technology Guide Medical Providers, in Treating Chronic Conditions With RIVER Ketamine Protocols Safely at Home? [NCT06070766] | 50,000 participants (Anticipated) | Observational | 2023-10-01 | Recruiting | |||
| Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Ketamine [NCT03621085] | Phase 4 | 43 participants (Actual) | Interventional | 2018-06-01 | Completed | ||
| Comparative Study of Ketamine Added to Bupivacaine in PECS Block Versus Topical Wound Instillation on Post Operative Analgesia in Modified Radical Mastectomy Surgery [NCT05410158] | Early Phase 1 | 60 participants (Anticipated) | Interventional | 2023-05-15 | Not yet recruiting | ||
| Influence of Ketamine on a Closed-Loop Anesthesia System [NCT02011347] | Phase 3 | 67 participants (Actual) | Interventional | 2013-07-31 | Terminated | ||
| Ketamine-Assisted Mindfulness-Based Cognitive Therapy for Depression: A Pilot Study [NCT05950711] | Phase 4 | 21 participants (Anticipated) | Interventional | 2022-03-30 | Recruiting | ||
| Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery as Part of an Enhanced Recovery After Surgery Protocol: A Randomized Prospective Single- Center Trial. [NCT02958566] | Phase 4 | 80 participants (Anticipated) | Interventional | 2017-01-31 | Recruiting | ||
| Neurophysiology and Pharmacology of Cough Reflex Hypersensitivity [NCT00858624] | 24 participants (Actual) | Interventional | 2008-02-29 | Completed | |||
| Acute Pain Management in Patients on Opioid Replacement Therapy [NCT03933865] | Phase 1 | 1 participants (Actual) | Interventional | 2018-10-31 | Terminated(stopped due to The COVID-19 pandemic and recruitment difficulties prompted the investigators to terminate study early.) | ||
| Impact of the Route of Administration of Ketamine Associated With Morphine PCA on Analgesia After Total Hip Arthroplasty [NCT00797264] | 18 participants (Actual) | Interventional | 2008-11-30 | Completed | |||
| A Double-blind Pilot Trial of the Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression. [NCT02593643] | Early Phase 1 | 9 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| Study of Respiratory Depression During Analgosedation Technique Combining Remifentanyl and Ketamine in TCI for Oocyte Retrieval [NCT03458143] | 20 participants (Anticipated) | Observational | 2018-02-12 | Recruiting | |||
| A Pilot Study Of The Efficacy Of WafermineTM Alone And In Combination With Opioids In Subjects Undergoing Bunionectomy [NCT02541396] | Phase 2 | 72 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| The Effect of Ketamine on the WAVCNS Index During General Anesthesia: A Feasibility Study [NCT02908945] | 30 participants (Actual) | Interventional | 2016-09-30 | Completed | |||
| Propofol-Ketamine (Ketofol) Versus Propofol-Fentanyl (Fenofol) as Procedural Sedation for Unilateral Open Carpal Tunnel Release Under Local Anesthesia [NCT04686448] | Phase 1/Phase 2 | 56 participants (Anticipated) | Interventional | 2021-01-01 | Recruiting | ||
| Effects of a Personal Ketamine-assisted Therapy Experience on Clinicians' Therapeutic Competencies Within a Psychedelic-assisted Therapy Training Program [NCT05468047] | Early Phase 1 | 500 participants (Anticipated) | Interventional | 2022-09-30 | Not yet recruiting | ||
| Influence of Anesthetics on Sedation and Antinociception: an Analysis of Auditory Evoked, Visceral Evoked and Heat Evoked Potentials [NCT00534586] | Phase 4 | 60 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| Comparative Study Between Ketamine-Bupivacaine Versus Bupivacaine With Intravenous Ketamine Infusion In Supraclavicular Brachial Plexus Block During Upper Limb Surgeries [NCT05315271] | Early Phase 1 | 60 participants (Actual) | Interventional | 2022-06-01 | Completed | ||
| Does a Single Intravenous Dose of Ketamine Reduce the Need for Supplemental Opioids in Post-Cesarean Section Patients? [NCT00486902] | 188 participants (Actual) | Interventional | 2006-07-31 | Completed | |||
| The Opioid Sparing Effect of Minimal Dose S-Ketamine Applied as a Coanalgesic During the Perioperative Period - An Active Placebo-Controlled, Double Blinded, Randomized Clinical Trial (МiniKet) [NCT01022840] | Phase 3 | 60 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| The Impact of Ketamine on the Reward Circuitry of Suicidal Patients: An MRI Study [NCT02532153] | Phase 3 | 0 participants (Actual) | Interventional | 2017-02-28 | Withdrawn(stopped due to No funding.) | ||
| A Phase I, Multi-centre, Double-blind, Placebo-controlled Parallel Group Study to Assess the pharmacoMRI Effects of AZD6765 in Male and Female Subjects Fulfilling the Criteria for Major Depressive Disorder [NCT01046630] | Phase 1 | 128 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia [NCT05210764] | 90 participants (Anticipated) | Observational | 2022-06-30 | Not yet recruiting | |||
| Ketamine for the Treatment for Opioid Use Disorder and Suicidal Ideation in the Emergency Department [NCT06111339] | Phase 2 | 50 participants (Anticipated) | Interventional | 2024-03-31 | Not yet recruiting | ||
| Phase I Randomized, Single-blind, Placebo-controlled, Single-center Study of the Effect of Postoperative Administration of Single Dose Ketamine on Pain and Recovery After Robotic Removal of Endometriosis in Patients With Chronic Pelvic Pain [NCT05229653] | Phase 1 | 30 participants (Anticipated) | Interventional | 2022-04-12 | Recruiting | ||
| Ketamine In Thoracic Surgery (KITS) Trial [NCT00504725] | Phase 2 | 40 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| [NCT00614159] | 34 participants (Anticipated) | Observational | 2007-10-31 | Completed | |||
| Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE1) [NCT05907213] | Phase 1 | 12 participants (Anticipated) | Interventional | 2023-09-25 | Recruiting | ||
| EARLY PREOPERATIVE ESCALATING DOSES OF KETAMINE ATTENUATE POSTOPERATIVE PAIN AND REDUCE MORPHINE CONSUMPTION IN HUMANS [NCT01070108] | 120 participants (Actual) | Interventional | 2007-01-31 | Completed | |||
| Effects of Prophylactic Administration of Ketamine on Acute and Chronic Pain After Thoracotomy for Lung Cancer, a Double Blind Randomised Trial. [NCT03105765] | 200 participants (Actual) | Interventional | 2011-01-31 | Completed | |||
| A Prospective Randomized Double Blinded Control Trial Using Ketamine or Propofol Anesthesia for Electroconvulsive Therapy: Improving Treatment-Resistant Depression [NCT01935115] | Phase 4 | 27 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Assessment of Topical Treatment Response With Amitriptyline and Ketamine: Combination Trial in Chemotherapy Peripheral Neuropathy (ATTRACT-CPN) [NCT00471445] | Phase 3 | 462 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| Investigating the Effect of a Perioperative Analgesia Protocol on Postoperative Opioid Usage and Pain Control in Patients Undergoing Major Head and Neck Cancer Surgery Requiring Microvascular Free Flap Reconstruction [NCT04176419] | Phase 3 | 30 participants (Anticipated) | Interventional | 2020-01-17 | Active, not recruiting | ||
| Treatment of Suicidal Ideation With Intravenous Ketamine Infusion [NCT01887990] | 18 participants (Actual) | Interventional | 2012-05-31 | Completed | |||
| [NCT00209885] | Phase 4 | 60 participants | Interventional | 2005-10-31 | Not yet recruiting | ||
| Phase 2 Optimization of the Antidepressant Action of Ketamine in Treatment-Resistant Depression and Investigations on Its Mechanism of Action [NCT01945047] | Phase 2/Phase 3 | 46 participants (Actual) | Interventional | 2013-05-31 | Completed | ||
| Remifentanil-based Total Intravenous Anesthesia for Pediatric Rigid Bronchoscopy: Comparison of Propofol and Ketamine As Adjuvant [NCT01947114] | Phase 4 | 40 participants (Actual) | Interventional | 2005-11-30 | Completed | ||
| Brain Injury and Ketamine: a Prospective, Randomized Controlled Double Blind Clinical Trial to Study the Effects of Ketamine on Sedative Sparing and Intracranial Pressure in Traumatic Brain Injury Patients. [NCT05097261] | Phase 4 | 100 participants (Anticipated) | Interventional | 2021-09-06 | Recruiting | ||
| Low-dose Ketamine as Adjuvant Treatment to Morphine in Neuropathic Cancer Pain [NCT01951911] | Phase 3 | 0 participants (Actual) | Interventional | 2013-09-30 | Withdrawn(stopped due to Poor patient recruitment. Vast majority of the patients have exclusions criteria) | ||
| Use of a Multimedia Presentation to Enhance the Informed Consent for Ketamine Sedation in a Pediatric Emergency Department [NCT01955070] | 184 participants (Actual) | Interventional | 2011-05-31 | Completed | |||
| DECREASING THE NEED FOR MECHANICAL VENTILATION AFTER RETINOPATHY OF PREMATURITY SURGERY: Sedation vs General Anesthesia [NCT01955135] | Phase 4 | 60 participants (Actual) | Interventional | 2010-09-30 | Completed | ||
| Boosting and Guiding Neuroplasticity by Combining Ketamine With Neurofeedback-assisted Learning - Towards an Individualized and Integrated Pharmaco-psychotherapy for Cocaine Addiction [NCT06125054] | Phase 2 | 120 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| A Randomized Control Trial Evaluating the Utility of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery [NCT04144933] | Phase 3 | 60 participants (Anticipated) | Interventional | 2021-05-15 | Recruiting | ||
| A Prospective Randomized Controlled Trial of Electroconvulsive Therapy With Ketamine Anesthesia (Standard Therapy) and High Intensity Ketamine With Electroconvulsive Therapy Rescue for Treatment-Resistant Depression - EAST HIKER Trial [NCT03272698] | Phase 4 | 62 participants (Anticipated) | Interventional | 2017-09-01 | Recruiting | ||
| Prospective Study of Induction Medications Used in the Rapid Sequence Intubation of Trauma Patients and a Comparison of Effects on Outcomes [NCT04291521] | 7,000 participants (Anticipated) | Observational | 2024-01-01 | Not yet recruiting | |||
| The Efficacy of Intraoperative Ketamine in Patients Undergoing Robot-assisted Thyroidectomy [NCT01997801] | 64 participants (Anticipated) | Interventional | 2013-12-31 | Not yet recruiting | |||
| Imaging Neural Correlates of Antidepressant Action of Ketamine Stereoisomers Using Pharmacological PET/MR Imaging and Metabolite Analysis. [NCT04587778] | Phase 1 | 65 participants (Anticipated) | Interventional | 2020-10-31 | Not yet recruiting | ||
| Safety and Efficacy of Sedation for Flexible Fiberoptic Bronchoscopy: Comparison of Propofol/Alfentanil With Propofol/Ketamine [NCT02000206] | 80 participants (Anticipated) | Interventional | 2014-02-28 | Not yet recruiting | |||
| Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain [NCT00224588] | Phase 3 | 80 participants | Interventional | 2003-01-31 | Completed | ||
| Comparative Study of Hemodynamic Changes and Sedation Effect of Dexmedetomidine Versus Dexmedetomidine With Ketamine in Mechanically Ventilated ARDS Patients, Randomized Clinical Trial [NCT05951387] | Phase 4 | 60 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | ||
| Ketofol vs Dexmedetomidine for Preventing Post-operative Delirium in Elderly Patients Undergoing Intestinal Obstruction Surgeries. A Randomized Controlled Study [NCT04816162] | Phase 4 | 120 participants (Actual) | Interventional | 2021-03-25 | Completed | ||
| Ketamine Versus Dexmedetomidine as an Adjuvant in Ultrasound-guided Supraclavicular Brachial Plexus Block [NCT04508894] | 75 participants (Actual) | Interventional | 2019-04-21 | Completed | |||
| Acute and Maintenance Intravenous Ketamine for Treatment Resistant Major Depression With Suicidal Ideation/Attempt [NCT02094898] | Phase 2 | 12 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| A Double-blind, Randomised Placebo-controlled Trial to Determine Whether Low-dose Intravenous Ketamine Peri-operatively Can Prevent Chronic Post-surgical Pain, in Patients Undergoing Thoracotomy or Video Assisted Thoracic Surgery (VATS) [NCT01296347] | Phase 4 | 77 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| A Comparison Between the Correlation of the Bispectral Index Versus Snap Index With the Observer's Assessment of Alertness and Sedation (OAA/S) Scale During a Sedation Regimen With and Without Ketamine [NCT01250418] | 25 participants (Actual) | Interventional | 2010-08-31 | Terminated(stopped due to Monitor manufacturer stopped marketing plan for the product.) | |||
| Ketamine Use in Electroconvulsive Therapy: Clinical, Cognitives and Neurotrophic Outcomes [NCT02012335] | 0 participants (Actual) | Interventional | 2014-01-31 | Withdrawn(stopped due to Methodologicals and logistics issues.) | |||
| Plasma Concentration of Ketamine and Norketamine in Patients on Oral Ketamine for Chronic Neuropathic Pain : A Pilot Study. [NCT02016664] | 12 participants (Actual) | Interventional | 2014-04-30 | Completed | |||
| The Effectiveness of Ketamine Continuous Infusion on Opioid Consumption and Pain Management in Severe Burned Patients, a Randomized, Double-blind, Placebo-controlled Study [NCT02860117] | Phase 3 | 0 participants (Actual) | Interventional | 2018-01-31 | Withdrawn(stopped due to change in hospital policy) | ||
| Effects of Ketamine in Post-operative Pain and Recovery Outcomes in Bilateral Third Molar Surgery Under General Anaesthesia [NCT02021240] | Phase 3 | 150 participants (Actual) | Interventional | 2014-02-10 | Completed | ||
| Prevention of Emergence Agitation in Children After Sevoflurane Anesthesia With Ketamine-midazolam Combination: A Prospective Randomized Clinical Trial [NCT02022488] | Phase 4 | 78 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Ketamine Anesthesia to Enhance Efficacy and Tolerability of Electroconvulsive Therapy in Patients With Unipolar or Bipolar Depression [NCT01309581] | 3 participants (Actual) | Interventional | 2010-04-30 | Terminated(stopped due to limited enrollment) | |||
| Ketamine Versus Magnesium Sulfate in the Time and Awakening Quality of General Anesthesia. Randomized Clinical Study. [NCT04360473] | 140 participants (Anticipated) | Interventional | 2022-03-14 | Recruiting | |||
| The Effect of Low Dose Ketamine on Narcotic Consumption in Patients Undergoing Laparoscopic Cholecystectomy [NCT05444777] | 86 participants (Actual) | Interventional | 2013-01-17 | Completed | |||
| Effects of Ketamine on Human Bladders and Its Possible Mechanisms [NCT00957333] | 44 participants (Actual) | Observational | 2009-03-31 | Completed | |||
| Dexmedetomidine-ketamine Combination Versus Fentanyl-midazolam for Patient Sedation During Flexible Bronchoscopy: a Prospective, Single-blind, Randomized Controlled Trial [NCT06185127] | Phase 3 | 50 participants (Actual) | Interventional | 2019-09-01 | Completed | ||
| Potential Role of Intravenous Lidocaine Versus Intravenous Ketamine for Pain Management in Fibromyalgia Patients [NCT06184958] | Phase 4 | 75 participants (Anticipated) | Interventional | 2023-09-02 | Recruiting | ||
| TREK: Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI Cancers [NCT06001372] | Early Phase 1 | 12 participants (Anticipated) | Interventional | 2023-10-13 | Recruiting | ||
| Rapid Antidepressant Response to Ketamine and Impact on Healthcare Utilization After Administration in the Emergency Department [NCT04266288] | Phase 4 | 29 participants (Actual) | Interventional | 2019-10-18 | Completed | ||
| Intranasal (IN) Ketamine in Treatment-Resistant Depression (TRD) [NCT01304147] | 20 participants (Actual) | Interventional | 2011-10-31 | Completed | |||
| Use of Ketamine Prior to Cardiopulmonary Bypass in Children [NCT00556361] | Phase 2 | 24 participants (Actual) | Interventional | 2004-07-31 | Completed | ||
| Ketamine for Analgesia After Cesarean Section [NCT04545801] | 80 participants (Actual) | Interventional | 2019-01-01 | Completed | |||
| Intravenous Ketamine Effects on Functional Neuroanatomy [NCT04205890] | Phase 1 | 0 participants (Actual) | Interventional | 2020-05-02 | Withdrawn(stopped due to Sponsor is no longer interested in funding the study) | ||
| Comparison of Effectiveness of Adding Ketamine or Neostigmine to Bupivacaine for Ultrasound Guided Serratus Anterior Plane Block in Modified Radical Mastectomy , Randomized Double Blinded Comparative Study. [NCT04544228] | 90 participants (Actual) | Interventional | 2020-09-05 | Completed | |||
| A Randomized, Double-blind, Placebo-controlled, Cross-over Study to Assess the Safety, Tolerability and Efficacy of Oral Ketamine for Patients With Rett Syndrome [NCT03633058] | Phase 2 | 24 participants (Actual) | Interventional | 2019-03-12 | Completed | ||
| Intra-nasal Ketamine for Analgesia in the Emergency Department [NCT01686009] | Phase 4 | 40 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
| Evaluation of Safety and Efficacy of Sub-anesthetic Ketamine Infusions as a Treatment for Patients Diagnosed With Resistant Major Depression [NCT02219867] | 10 participants (Anticipated) | Interventional | 2014-08-31 | Not yet recruiting | |||
| Efficacy of Adding Low Dose Ketamine or Fentanyl to Propofol-dexmedetomidine as Total Intravenous Anesthesia for Patients Undergoing Craniotomy [NCT06031883] | Phase 1/Phase 2 | 40 participants (Anticipated) | Interventional | 2023-02-01 | Recruiting | ||
| Randomized Blinded, Placebo Controlled Trial Of Intrapoperative Ketamine For Patients Undergoing Total Joint [NCT04437888] | Early Phase 1 | 200 participants (Actual) | Interventional | 2020-09-14 | Active, not recruiting | ||
| Comparison of Nebulized Sub-dissociative Dose Ketamine at Three Different Dosing Regimens for Treating Acute Pain in the Pediatric ED: A Prospective, Randomized Double-Blind Trial [NCT03950817] | Phase 4 | 120 participants (Anticipated) | Interventional | 2019-05-13 | Recruiting | ||
| A Prospective, Randomized, Single-Blinded Trial of Ketamine Versus Lidocaine Infusions for Multimodal Pain Management in Traumatic Rib Fracture Patients [NCT04781673] | Phase 4 | 74 participants (Anticipated) | Interventional | 2021-04-01 | Recruiting | ||
| KETACANCER: Prospective Multicentre Study of the Use of Ketamine in the Treatment of Refractory Chronic Pain in the French CLCC [NCT04459234] | 81 participants (Actual) | Observational | 2021-02-02 | Completed | |||
| Modulation of μ Opioid Receptor Mediated Analgesia, Tolerance and Hyperalgesia in Children and Adolescents [NCT01325493] | Phase 4 | 54 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| Immunomodulatory Properties of Ketamine in Sepsis [NCT01089361] | Phase 1/Phase 2 | 19 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| The Effect of Intraoperative Dexmedetomidine-Ketamine Infusion on the Patients Undergoing Radical Mastectomy: Randomized Controlled Study [NCT04048226] | Phase 4 | 98 participants (Actual) | Interventional | 2019-09-01 | Completed | ||
| Comparison of Treatment by IM Ketamine to IV Ketamine in Patients With Renal Colic [NCT04013958] | Phase 3 | 100 participants (Anticipated) | Interventional | 2019-08-01 | Not yet recruiting | ||
| A Comparative Study of the Effect of Propofol Infusion Versus the Combination of Ketamine and Dexmedetomidine Infusion on the Amplitude of Motor Evoked Potential in Pediatrics Undergoing Tethered Spinal Cord Surgeries a Randomized, Double-blinded Controll [NCT05591001] | Phase 1 | 46 participants (Anticipated) | Interventional | 2022-10-30 | Recruiting | ||
| Evaluation of Efficacy and Safety of Levetiracetam, Lacosamide and Ketamine as Adjunctive Treatment of Refractory Status Epilepticus [NCT02726867] | Phase 3 | 0 participants (Actual) | Interventional | 2014-02-28 | Withdrawn(stopped due to No participants enrolled) | ||
| Effect of Ketamine, at the Induction and Its Maintenance to Prevent the Post-operative Pain: Clinical Trial in Cancerology [NCT00210210] | Phase 3 | 230 participants (Actual) | Interventional | 2004-02-29 | Completed | ||
| Pre-hospital Utilization of Nebulized Sub-dissociative Dose Ketamine for Managing Acute Traumatic Extremity Pain: a Prospective Observational Study [NCT04162028] | Phase 4 | 0 participants (Actual) | Interventional | 2019-01-15 | Withdrawn(stopped due to Investigators not interested any more in the study) | ||
| Proper Dosage of Intravenous Ketamine When Used as an Adjuvant to Lidocaine in Intravenous Regional Anesthesia (IVRA). [NCT00221871] | 0 participants | Interventional | 2004-01-31 | Recruiting | |||
| Intranasal Ketamine Effectiveness in Reducing Intramuscular Injection Pain Before Sedation Among Children [NCT06139380] | Phase 4 | 90 participants (Anticipated) | Interventional | 2023-12-02 | Recruiting | ||
| Connectivity Changes Associated With Ketamine Assisted Psychotherapy for PTSD [NCT06036511] | Phase 1/Phase 2 | 14 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| Low-Dose Ketamine Infusion for the Treatment of Multiple Sclerosis Fatigue (INKLING-MS) [NCT05378100] | Phase 2 | 110 participants (Anticipated) | Interventional | 2023-01-01 | Recruiting | ||
| Effects of a Single Dose of Intravenous Ketamine on Symptoms of Gulf War Illness in 1990-1991 Gulf War Veterans [NCT04712071] | Early Phase 1 | 1 participants (Actual) | Interventional | 2021-02-01 | Terminated(stopped due to Due to the COVID pandemic we could not enroll more than one subject before funding was ending.) | ||
| Effects of Ketamine on Eye Movements, Perception and Brain Function [NCT02701933] | 24 participants (Actual) | Interventional | 2014-04-30 | Completed | |||
| A Comparison Between the Effects of Perioperative Intravenous Lidocaine and Ketamine on Acute and Chronic Pain After Open Nephrectomy: A Prospective, Double-blind, Randomized, Placebo Controlled Study [NCT02653651] | Phase 4 | 60 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| The Effect of Intraoperative Lidocaine Infusion and Intraoperative Lidocaine Combined With Ketamine Infusion on Opioid Consumption After Laparoscopic Bariatric Surgery: A Randomized Controlled Trial [NCT04524130] | Phase 4 | 87 participants (Anticipated) | Interventional | 2021-04-01 | Active, not recruiting | ||
| The Effect of Different Doses of Ketamine on Tracheal Intubating Conditions Using Low Dose Rocuronium in Children [NCT02646709] | Phase 4 | 60 participants (Anticipated) | Interventional | 2016-01-31 | Not yet recruiting | ||
| Efficacy of Postoperative Analgesia Offered by Local Ketamine Wound Instillation Following Total Thyroidctomy; a Randomized, Double-blind, Controlled-clinical Trial [NCT02642497] | Phase 2/Phase 3 | 90 participants (Actual) | Interventional | 2015-08-31 | Completed | ||
| A Prospective Randomised, Double-blinded Cross-over Study to Investigate the Effects of Racemic and S-ketamine on Cerebral Blood Flow on Healthy Volunteers With MRI-ASL [NCT01506921] | 14 participants (Anticipated) | Interventional | 2011-05-31 | Completed | |||
| Intranasal Ketamine Versus Intravenous Ketamine for Procedural Sedation in Children: a Multi-centre Randomized Controlled Non-inferiority Trial [NCT02828566] | Phase 3 | 470 participants (Anticipated) | Interventional | 2017-10-31 | Not yet recruiting | ||
| Biomarkers of Response to Ketamine in Depression [NCT04216888] | Phase 2/Phase 3 | 9 participants (Actual) | Interventional | 2019-06-26 | Completed | ||
| Intranasal Ketamine Use in Autism Spectrum Disorder: A Placebo-Controlled Crossover Pilot Study [NCT02611921] | Phase 1 | 21 participants (Actual) | Interventional | 2015-12-22 | Completed | ||
| Parallel Effects of Ketamine and Schizophrenia on Neurocognitive Function [NCT02675530] | Phase 1 | 33 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| Untersuchung Unterschiedlicher Sedationstechniken für Elektive Magnetresonanztomographie (MRT)-Diagnostik Bei Kindern Anhand Klinischer Und MRT-basierter Outcomeparameter (Propofol Versus Propofol-Ketamin) [NCT01519154] | Phase 3 | 347 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| Intraoperative Ketamine and Methadone for Laminectomy: Effect on Recovery, Postoperative Pain, and Opioid Requirements [NCT02252432] | Phase 4 | 13 participants (Actual) | Interventional | 2013-02-28 | Terminated(stopped due to No enough recruitments, very slow enrollment over the years) | ||
| Ketamine Improves Post-Thoracotomy Analgesia [NCT00625911] | 44 participants (Actual) | Interventional | 2001-09-30 | Completed | |||
| Intranasal Ketamine Versus Intranasal Midazolam Plus Fentanyl in Treating Pain Associated With Incision and Drainage of Abscesses in the Pediatric Emergency Department: A Randomized Controlled Trial [NCT02635282] | Phase 4 | 19 participants (Actual) | Interventional | 2016-08-31 | Completed | ||
| A Pilot Study of Sub-anesthetic Ketamine Infusion for Neuroprotection After Aneurysmal Subarachnoid Hemorrhage: Effects on White Matter Integrity, Inflammatory Biomarkers and Neurocognitive Outcome [NCT02636218] | Phase 2/Phase 3 | 50 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting | ||
| Effect of Ketamine-propofol Mixture on Postoperative Pain and Sedation-agitation [NCT02848963] | Phase 4 | 75 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| Low Dose Ketamine Infusion for the Treatment of Resistant Depression [NCT04283058] | 0 participants (Actual) | Observational | 2020-06-29 | Withdrawn(stopped due to Covid-19 disruption of team) | |||
| An Open-label, Single Ascending Dose Study to Investigate the Safety, Tolerability and Pharmacokinetics of Sublingually Administered (S)-Ketamine Oral Solution in Healthy Participants [NCT04282746] | Phase 1 | 17 participants (Actual) | Interventional | 2020-02-18 | Completed | ||
| Intra-operative Use of Ketamine for Post-Operative Analgesia in Patients Undergoing Hemorrhoidectomy: A Prospective, Randomized Controlled Trial. [NCT04248205] | Phase 4 | 100 participants (Anticipated) | Interventional | 2020-06-15 | Recruiting | ||
| Intravenous Sedation and Analgesia Using Propofol, Fentanyl and Ketamine (PFK) Versus General Anesthesia in Minor Urological Procedures. [NCT04285528] | 200 participants (Actual) | Interventional | 2019-04-17 | Completed | |||
| Pilot Study: The Effect of Intraoperative Ketamine on Analgesia Post-Cardiac Surgery and Prevention of Chronic Pain [NCT02925858] | Phase 4 | 80 participants (Actual) | Interventional | 2017-08-28 | Completed | ||
| Comparison Between Low-dose Ketamine Infusion and Intravenous Morphine Infusion for Analgesia in Laparotomy Myomectomy: A Double-blind, Randomized, Controlled Clinical Trial [NCT04281628] | Phase 4 | 80 participants (Actual) | Interventional | 2019-02-21 | Completed | ||
| Ketamine Treatment for Pediatric-Refractory Obsessive-Compulsive Disorder (OCD) [NCT02422290] | Phase 1/Phase 2 | 5 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| Efficacy and Safety of Ketamine Versus Magnesium Sulphate as Adjuvants to Levobupivacaine in Ultrasound (US) Bi-level Erector Spinae Block in Breast Cancer Surgery [NCT04275661] | Phase 2 | 60 participants (Anticipated) | Interventional | 2020-08-01 | Active, not recruiting | ||
| Evaluation of Ketamine and Multi-modal Analgesics for Postoperative Analgesia, Opioid Sparing, and Early Extubation in ICU Compared With Conventional Analgesia [NCT02815111] | 0 participants (Actual) | Observational | 2016-07-31 | Withdrawn(stopped due to Not IRB approved) | |||
| The Role of Ketamine in Preventing Cognitive Dysfunctions in Postoperative Period of Cardiac Surgery [NCT02782429] | Phase 4 | 50 participants (Anticipated) | Interventional | 2016-04-30 | Recruiting | ||
| Continuous Ketamine Infusion Versus Placebo in the Treatment of Acute Post-Surgical Pain: A Randomized Trial Evaluating the Efficacy of Ketamine in Colorectal Surgery [NCT02785003] | Phase 4 | 0 participants (Actual) | Interventional | 2016-07-31 | Withdrawn(stopped due to Lack of Funding) | ||
| The Efficacy and Safety of S-ketamine in Elective Cesarean Section: a Multi-center, Randomized, Double-blind, Placebo-controlled Clinical Study [NCT04657107] | 402 participants (Anticipated) | Interventional | 2020-12-01 | Not yet recruiting | |||
| Intranasal Dexmedetomidine and Fentanyl Versus Intravenous Midazolam and Ketamine in Sedation for Painful Outpatient Procedures [NCT04621110] | Phase 3 | 60 participants (Anticipated) | Interventional | 2021-06-01 | Not yet recruiting | ||
| [NCT01404442] | Phase 1/Phase 2 | 90 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression [NCT02772211] | Phase 4 | 60 participants (Anticipated) | Interventional | 2016-06-30 | Not yet recruiting | ||
| Effect of Ketamine (Ketalar) on Intracranial Pressure [NCT00437814] | 30 participants | Interventional | 2005-09-30 | Recruiting | |||
| Ketamine Tolerance in Children After Repeated Administrations During Radiotherapy Sessions [NCT02512055] | Phase 4 | 33 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| Comparing Low Dose IV Ketamine-midazolam Versus IV Morphine Regarding ED Pain Control in Patients Sustaining Closed Limb Fracture(s) [NCT01807429] | Phase 2/Phase 3 | 236 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| Efficacy and Safety of Esketamine or Sevoflurane Add to Dexmedetomidine-based Sedation for Ophthalmology Procedure in Children [NCT05321160] | 116 participants (Actual) | Interventional | 2021-03-10 | Completed | |||
| Phase 4 Study of Prevention of Persistent Postsurgical Pain After Thoracotomy Using Ketamine [NCT01243801] | Phase 4 | 104 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| Analgesic Effect of Ketamine in Patients Undergoing Hysteroscopic Endometrial Thermal Ablation Surgery [NCT01106846] | 22 participants (Actual) | Interventional | 2010-03-31 | Terminated(stopped due to Resources not available to complete.) | |||
| A Comparison of Proprietary Formulations of Oral Ketamine + Aspirin and Oral Ketamine Alone in Adult Patients Presenting to the ED With Acute Musculoskeletal Pain: Prospective, Randomized, Open-Label, Clinical Trial. [NCT04860804] | Phase 4 | 60 participants (Actual) | Interventional | 2021-04-22 | Completed | ||
| Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder [NCT00749203] | Phase 2 | 41 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| Administration of Ketamine to Branchial Plexus Block Using Axillary Approach : Comparative Study [NCT05297422] | 81 participants (Anticipated) | Interventional | 2022-01-20 | Recruiting | |||
| Effect of Ketamine+Propofol vs Remifentanyl+Propofol on Laryngeal Mask Insertion Conditions [NCT02583217] | 50 participants (Actual) | Observational [Patient Registry] | 2015-04-30 | Completed | |||
| The Effect of Perioperative Intravenous Low-dose Ketamine on Acute and Chronic Neuropathic Pain After Major Back Surgery. A Randomised, Placebo-controlled, Double-blind Study [NCT00618423] | Phase 2 | 160 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| Optimization of Intravenous Ketamine for Treatment-Resistant Depression: A Randomized, Placebo-Controlled, Triple-masked, Clinical Trial [NCT00768430] | Phase 2 | 73 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS [NCT00579085] | Phase 2 | 40 participants (Anticipated) | Interventional | 2006-09-30 | Completed | ||
| Perioperative Use of Ketamine Infusion vs Dexmedetomidine Infusion as Analgesic in Obese Patients Undergoing Bariatric Surgery [NCT04576975] | Phase 3 | 90 participants (Actual) | Interventional | 2021-04-20 | Active, not recruiting | ||
| Pilot Study of Ketamine-assisted Talk Therapy for Demoralization in Patients With Pancreatic Ductal Adenocarcinoma and Pain [NCT06077487] | Phase 4 | 12 participants (Anticipated) | Interventional | 2024-02-01 | Not yet recruiting | ||
| Effects of Small-dose S-ketamine on Anesthesia-induced Atelectasis in Patients Undergoing General Anesthesia Accessed by Pulmonary Ultrasound：Study Protocol for a Randomized, Double-blinded Controlled Trial [NCT04745286] | Early Phase 1 | 100 participants (Anticipated) | Interventional | 2021-03-31 | Not yet recruiting | ||
| Comparative Randomized Controlled Trial Study of General Balanced Anesthesia Based on Opioid and Opioid Sparing Balanced Anesthesia for Cholecystectomy Surgery Via Laparoscopy: Intraoperative and Postoperative Outcomes [NCT02953210] | Phase 4 | 40 participants (Anticipated) | Interventional | 2016-11-30 | Enrolling by invitation | ||
| A Prospective Study of Low Dose Ketamine as an Adjunct to Fentanyl in Pediatric Patients Following Outpatient Tonsillectomy and Adenoidectomy [NCT00587665] | 122 participants (Actual) | Interventional | 2006-08-31 | Completed | |||
| Randomized, Single-blind, Placebo-controlled Study on the Effect of Postoperative Administration of Single Dose Ketamine After Mastectomy on Pain [NCT04831736] | Phase 4 | 31 participants (Actual) | Interventional | 2021-04-26 | Completed | ||
| [NCT01855581] | 3,739 participants (Anticipated) | Observational | 2012-11-30 | Recruiting | |||
| Ketamine for Treatment-resistant Depression: A Multicentric Clinical Trial in Mexican Population [NCT01868802] | Phase 2 | 60 participants (Anticipated) | Interventional | 2013-09-30 | Recruiting | ||
| Efficacy and Safety of Esketamine Combined With Dexmedetomidine for Sedation Iof Mechanically Ventilated Patients in the ICU: a Prospective, Randomized, Single-center Study [NCT05466708] | Phase 4 | 120 participants (Anticipated) | Interventional | 2022-08-31 | Not yet recruiting | ||
| Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions [NCT00596050] | Phase 4 | 50 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery (VATS) - A Randomized Controlled Trial. [NCT03809442] | Phase 4 | 120 participants (Anticipated) | Interventional | 2019-06-25 | Recruiting | ||
| Continuation Intravenous Ketamine in Major Depressive Disorder - Modification: Lithium for Relapse Prevention [NCT00548964] | Phase 1 | 36 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| The Effects of Ketamine on Postoperative Pain After Intraoperative Remifentanil Infusions in Bariatric Surgery [NCT03389022] | Phase 4 | 64 participants (Anticipated) | Interventional | 2015-07-22 | Enrolling by invitation | ||
| Intranasal Ketamine for Pediatric Procedural Sedation: a Feasibility Study [NCT03067974] | Early Phase 1 | 10 participants (Actual) | Interventional | 2017-09-21 | Terminated(stopped due to Initial results did not show benefit.) | ||
| Initiating Ketamine in Acutely Suicidal Patients in the Emergency Department [NCT04260607] | Phase 3 | 2 participants (Actual) | Interventional | 2020-01-14 | Terminated(stopped due to As a busy MTF we were unable to retain a health care provider with the appropriate expertise to buy-in to this study once the initiating PI left military service.) | ||
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine [NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated(stopped due to Efficacy was not seen after interim analysis) | ||
| Low-dose Ketamine Infusions for Perioperative Pain Management in Patients Undergoing Laparoscopic Gastric Bypass [NCT03448068] | Phase 2 | 34 participants (Actual) | Interventional | 2018-04-16 | Completed | ||
| A Pilot Study of a Single Infusion of Ketamine in Relief of Depressive Symptoms of Elderly Patients With Visual Impairment. [NCT03473431] | 90 participants (Actual) | Interventional | 2018-04-15 | Completed | |||
| Ketamine Versus Etomidate During Rapid Sequence Intubation: Consequences on Hospital Morbidity [NCT00440102] | Phase 4 | 655 participants (Actual) | Interventional | 2007-04-30 | Completed | ||
| A Randomized, Double-Blind, Placebo-Controlled Pilot Study of the Safety and Efficacy of 10 mg, 30 mg, and 50 mg of Transnasal Ketamine Hydrochloride (PMI-100) for the Treatment of Postoperative Dental Pain [NCT00488787] | Phase 2 | 40 participants (Actual) | Interventional | 2001-03-31 | Completed | ||
| The Prevention of Post Operative Cognitive Dysfunction by Ketamine: a Prospective Multicenter Randomized Blinded Placebo-controlled Trial in Elderly Patients Undergoing Elective Orthopaedic Surgery [NCT02892916] | Phase 3 | 307 participants (Actual) | Interventional | 2017-03-20 | Completed | ||
| A Prospective Randomized Double Blind Evaluation of Ketamine/Propofol vs Ketamine Alone for Pediatric Extremity Fracture Reduction [NCT00490997] | Phase 4 | 140 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy [NCT00129597] | Phase 4 | 40 participants | Interventional | 2004-12-31 | Active, not recruiting | ||
| A Randomized, Open Label, Single Center, Single-Dose Study to Assess the Effects of Certain Nasal Medications on the Pharmacokinetics, Safety and Tolerability of PMI-150 (Intranasal Ketamine Hydrochloride) 30 mg [NCT00520104] | Phase 1 | 48 participants (Anticipated) | Interventional | 2007-08-31 | Active, not recruiting | ||
| Low Dose Ketamine for Management of Acute Severe Pain in the Emergency Department [NCT01740492] | Phase 1 | 75 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| Intranasal Ketamine Versus Intramuscular Ketamine for Procedural Sedation: A Prospective Randomized, Double-blinded, Placebo Controlled Study [NCT01170247] | 3 participants (Actual) | Interventional | 2011-01-31 | Terminated(stopped due to lack of enrollment) | |||
| A Randomized, Open Label, Single Center, Single-Dose, Cross-Over Study to Determine the Absolute Bioavailability and the Nasopharyngeal Absorption of PMI-150 (Intranasal Ketamine) in Healthy Adult Volunteers [NCT00520169] | Phase 1 | 32 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| A Phase 1, Single-centre, Double-blind, Placebocontrolled Crossover Study to Assess the pharmacoMRI Effects of AUT00206 in Healthy Male Participants [NCT02935725] | Phase 1 | 22 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| Intranasal Ketamine for Peripheral Venous Puncture in Pediatric Patients: A Randomized Double Blind and Placebo Controlled Study [NCT02929524] | Phase 2/Phase 3 | 39 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| Effects of Local Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Surgical Stress Response and Postoperative Pain in Major Abdominal Cancer Surgery [NCT02927379] | Phase 3 | 90 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Ketamine Treatment of Youth Suicide Attempters for Fast Reduction of Severe Suicide Risk and Facilitation of Long-term Collaborative Clinical Engagement: A Double Blind Randomized Placebo Controlled Trial [NCT04763343] | Phase 3 | 140 participants (Anticipated) | Interventional | 2022-06-27 | Recruiting | ||
| A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue [NCT04141696] | Phase 1/Phase 2 | 59 participants (Anticipated) | Interventional | 2021-07-26 | Recruiting | ||
| Premedication With Different Nebulized Ketamine,Dexmedetomidine Versus Midazolam in Oncologic Preschool Children [NCT02935959] | Phase 1/Phase 2 | 90 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| Hyperventilation and ECT Seizure Duration: Effects on Cerebral Oxygen Saturation, and Therapeutic Outcome With Comparisons Between Etomidate and Ketamine in Patients With Major Depressive Disorder [NCT02924090] | Phase 4 | 48 participants (Anticipated) | Interventional | 2016-09-30 | Recruiting | ||
| Does Magnetic Resonance Imaging Increase Core Body Temperature in Anesthetized Children? Evaluating the Effects of Propofol and Ketofol [NCT02931786] | 90 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
| Intravenous Versus Caudal Supplementation of Ketamine for Postoperative Pain Control in Children,A Double-blind Controlled Clinical Trial. [NCT00532662] | Phase 4 | 40 participants (Anticipated) | Interventional | 2007-11-30 | Recruiting | ||
| Ketamine Pharmacokinetics in Children Undergoing Cardiac Surgery [NCT00598195] | 18 participants (Actual) | Interventional | 2006-06-30 | Completed | |||
| Intramuscular Ketamine Administration for the Treatment of Acute Suicidal Ideation With Concurrent EEG Monitoring [NCT05105061] | Phase 2 | 0 participants (Actual) | Interventional | 2022-02-28 | Withdrawn(stopped due to PI leaving institution) | ||
| Feasibility and Safety of Single Dose Ketamine for Acutely Suicidal Patients in the Emergency Department [NCT06085937] | Phase 1 | 50 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| The Effect of Ketamine - Dexmedetomidine Admixture (Ketodex) on Hemodynamic Stability During Anesthesia Induction in Adults: A Randomized Controlled Comparison of Two Doses [NCT05948267] | Phase 4 | 114 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| Monitored Anesthesia Care: Dexmedetomidine-Ketamine Versus Dexmedetomidine- Propofol Combination During Burr-Hole Surgery For Chronic Subdural Hematoma [NCT04621526] | Phase 1/Phase 2 | 56 participants (Actual) | Interventional | 2020-11-10 | Completed | ||
| Double-Blind Randomized Controlled Trial of Acute-Course of Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents [NCT04592809] | Phase 3 | 264 participants (Anticipated) | Interventional | 2022-10-03 | Recruiting | ||
| A Single Ketamine Infusion Combined With Music for Suicidal Ideation During a Depressive Episode: A Randomized Open Label Clinical Trial [NCT04658420] | Phase 2 | 200 participants (Anticipated) | Interventional | 2021-07-01 | Not yet recruiting | ||
| Open Randomized Clinical Trial to Examine Individual Pain Tolerance in the Use of Two Anesthetic Techniques to Perform Saturation Prostate Biopsy [NCT02909049] | Phase 4 | 100 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| A Single-center Phase I Open-label Study of the Tolerability and Efficacy of Low-dose Ketamine Infusion for Treatment of Levodopa-Induced Dyskinesia in Patients With Parkinson's Disease [NCT06021756] | Phase 1 | 9 participants (Actual) | Interventional | 2019-07-28 | Active, not recruiting | ||
| PCA Ketamine-Morphine Versus PCA Morphine as Post-Operative Analgesia in Colorectal Surgery [NCT06021717] | Phase 4 | 60 participants (Actual) | Interventional | 2018-04-05 | Completed | ||
| Investigations on the Efficacy of Ketamine in Depression in Comparison to Electroconvulsive Therapy [NCT03674671] | Phase 3 | 240 participants (Anticipated) | Interventional | 2018-10-29 | Suspended(stopped due to insufficient funding) | ||
| S-ketamine Prevents Tibial Fracture-associated Postoperative Pain and Cognitive Dysfunction After Orthopedic Surgery in Patients: a Randomized Double-blind Controlled Trial [NCT04643132] | 120 participants (Anticipated) | Interventional | 2020-12-15 | Recruiting | |||
| A Comparison of Midazolam or Haloperidol Premedication Versus Placebo for Reducing Ketamine Induced Agitation After Adult Procedural Sedation in the Emergency Department [NCT02909465] | Phase 4 | 185 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| Comparison of Sedation by Esketamine and Sevoflurane for Short Ophthalmological Procedure in Children [NCT05011214] | Phase 4 | 60 participants (Anticipated) | Interventional | 2021-09-20 | Enrolling by invitation | ||
| A Pivotal Phase 1, Randomized, Single-Dose, 4-Period, Crossover Relative Bioavailability Study of MELT-100, IV Midazolam, and IV Ketamine Under Fasted Conditions in Healthy Volunteers [NCT04767035] | Phase 1 | 25 participants (Actual) | Interventional | 2020-12-01 | Completed | ||
| Cardioprotective Effect of Ketamine-dexmeditomidine Versus Fentanyl-midazolam in Open-heart Surgery in Pediatrics: A Randomized Controlled Double-blinded Study [NCT05314569] | Phase 1 | 81 participants (Anticipated) | Interventional | 2022-04-15 | Recruiting | ||
| Efficacy and Safety of Opioid-free Anesthesia With Propofol Combined With S-ketamine in Laparoscopic Cholecystectomy: a Multicenter, Randomized, Controlled, Non-inferiority Clinical Study (SKOF - LC) [NCT05242081] | 980 participants (Anticipated) | Interventional | 2022-07-31 | Recruiting | |||
| Prospective Observational Evaluation of a New Protocol for Adult Procedural Sedation With Ketamine-propofol in a 1 on 4 Ratio at the Emergency Department of a Tertiary Hospital [NCT04028141] | 61 participants (Actual) | Observational | 2018-02-01 | Completed | |||
| Switching to Intranasal Esketamine Maintains the Antidepressant Response to Intravenous Racemic Ketamine Administration: A Case Series of 10 Patients [NCT04856124] | 10 participants (Actual) | Observational | 2018-09-01 | Completed | |||
| Ketamine for Treatment Resistant Depression - A Long Term Feasibility Study [NCT04021433] | 20 participants (Anticipated) | Interventional | 2018-09-01 | Recruiting | |||
| Comparison of the Effectiveness of Sedation With i.v. Dexmedetomidine in Combination With Midazolam Alone or Midazolam and Low Dose Ketamine for Extraction of Third Molars. [NCT01017237] | Phase 4 | 18 participants (Actual) | Interventional | 2009-07-31 | Terminated(stopped due to Protocol proved to be ineffective for adequate sedation for third molar surgery.) | ||
| Comparing the Efficacy of Intravenous Dexmedetomidine, Tramadol and Ketamine for Control of Post Spinal Shivering in Obstetric Patients Undergoing Lower Segment C-section [NCT05311722] | Phase 3 | 71 participants (Anticipated) | Interventional | 2022-04-30 | Not yet recruiting | ||
| A Randomized, Clinical Trial of Oral Midazolam Plus Placebo Versus Oral Midazolam Plus Oral Ketamine for Sedation During Laceration Repair [NCT01470157] | Phase 4 | 60 participants (Anticipated) | Interventional | 2011-07-31 | Recruiting | ||
| Comparison of Mg, Ketamine, Large Dose Rocuronium, and Priming on Intubating Condition in Rapid Sequence Intubation [NCT01479751] | 110 participants (Actual) | Interventional | 2011-11-30 | Completed | |||
| Prospective, Double-blinded, Randomised, Placebo Controlled Trial of Pre-emptive Analgesia to Prevent Pain Following Sternotomy for Cardiac Surgery. [NCT01480765] | Phase 4 | 150 participants (Anticipated) | Interventional | 2011-11-30 | Recruiting | ||
| N-acetylcysteine and NMDA Antagonist Interactions [NCT00611897] | Phase 1/Phase 2 | 16 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| A Randomised Controlled Trial of Lidocaine Infusion Plus Ketamine Injection Versus Placebo to Decrease Postoperative Ileus [NCT00229567] | 60 participants | Interventional | 2005-09-30 | Terminated(stopped due to insufficient numbers of eligible patients as laparscopic surgery increased and open surgery decreased.) | |||
| Effect of Racemic Ketamine on Pain in Females and Males After Surgical Removal of Third Molars [NCT00232492] | Phase 4 | 128 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| Ketamine vs. Midazolam in Bipolar Depression [NCT01944293] | Phase 1/Phase 2 | 16 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Low Dose Ketamine Infusion for Analgesia in the Emergency Department (ED) to Reduce Side Effects: A Double Blind, Double Dummy Randomized Controlled Trial [NCT05518877] | Phase 4 | 48 participants (Anticipated) | Interventional | 2022-12-07 | Recruiting | ||
| A Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Efficacy of Ketamine for the Treatment of Concurrent Opioid Use Disorder and Major Depressive Disorder [NCT04177706] | Phase 2 | 21 participants (Actual) | Interventional | 2020-12-17 | Completed | ||
| Lidocaine and Ketamine in Abdominal Surgery [NCT04084548] | Phase 3 | 420 participants (Anticipated) | Interventional | 2019-10-15 | Recruiting | ||
| Recovery Parameters and Nociception Levels in Opioid-free Versus Opioid Based Anesthesia for Thyroidectomy [NCT05243940] | 60 participants (Anticipated) | Interventional | 2022-03-07 | Recruiting | |||
| Analgesic Effects of Three Different Doses of Intrathecal Ketamine as an Adjuvant to Intrathecal Bupivacaine in Patients Undergoing Knee Arthroscopy. A Randomized Prospective Double-blinded Study [NCT05074823] | Phase 4 | 105 participants (Actual) | Interventional | 2022-02-26 | Completed | ||
| Comparative Evaluation of Intranasal Midazolam, Dexmedetomidine, Ketamine for Their Sedative Effect and the Ability to Facilitate Venous Cannulation in Pediatric Patients: a Prospective Randomized Study. [NCT04704622] | Phase 2/Phase 3 | 150 participants (Actual) | Interventional | 2021-01-01 | Completed | ||
| Ketamine Versus Fentanyl as an Adjunct to Propofol-Assisted Emergency Department Procedural Sedation [NCT00137085] | 124 participants | Interventional | 2004-09-30 | Completed | |||
| Patient Satisfaction With Subdissociative Dose Ketamine Versus Morphine for Emergency Department Pain Control [NCT04698772] | 32 participants (Actual) | Observational | 2019-12-19 | Completed | |||
| Consequences of Co-Administration of Propofol With Clonidine and Ketamine Throughout Colon Cancer Surgery [NCT05536362] | Phase 1 | 60 participants (Actual) | Interventional | 2021-02-01 | Completed | ||
| Low-dose Ketamine Versus Morphine for Severe Painful Sickle Cell Crises in Children at Mulago Hospital: A Randomised Controlled Trial [NCT02434939] | Phase 4 | 240 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study Comparing the Efficacy and Safety of PMI-150 (Intranasal Ketamine) to Placebo as an Analgesic for the Treatment of Breakthrough Pain in Cancer Patients [NCT00492388] | Phase 3 | 2 participants (Actual) | Interventional | 2007-06-30 | Terminated(stopped due to Business decision not to continue development) | ||
| Prospective Study on the Cost-Effectiveness of Adding Ketamine to Midazolam-Sufentanil Sedation Regimen in Mechanically Ventilated Patients [NCT00122759] | 100 participants (Anticipated) | Interventional | 2005-12-31 | Recruiting | |||
| A Randomized, Double-Masked, Controlled, Single Site Investigator Initiated, Exploratory Study of the Midazolam/Ketamine Melt vs Ketamine Melt Alone vs Midazolam Melt Alone in Subjects Undergoing Intraocular Surgery. [NCT04725747] | Phase 4 | 50 participants (Anticipated) | Interventional | 2021-01-25 | Not yet recruiting | ||
| The Use of Ketamine for Conscious Sedation in Flexible Bronchoscopy [NCT06181188] | Phase 4 | 66 participants (Actual) | Interventional | 2019-07-15 | Completed | ||
| Ketamine + Cognitive Training for Suicidality in the Medical Setting [NCT04578938] | Phase 4 | 200 participants (Anticipated) | Interventional | 2021-03-15 | Enrolling by invitation | ||
| The Effect of Ketamine in the Prevention of Hypoventilation in Patients Undergoing Deep Sedation Using Propofol and Fentanyl [NCT01825083] | 0 participants (Actual) | Interventional | Withdrawn(stopped due to Change in personnel) | ||||
| Evaluation of the Initial Prescription of Ketamine and Milnacipran Forin Depression in Patients With a Progressive Disease [NCT02783430] | Phase 2/Phase 3 | 80 participants (Anticipated) | Interventional | 2016-09-08 | Recruiting | ||
| Investigation of the Rapid (Next Day) Antidepressant Effects of an NMDA Antagonist [NCT00088699] | Phase 1/Phase 2 | 67 participants (Actual) | Interventional | 2004-07-26 | Completed | ||
| Use of Low-Dose Ketamine Infusion in Acute Painful Episodes of Sickle Cell Disease: A Pilot Study [NCT00595530] | Phase 2 | 3 participants (Actual) | Interventional | 2008-03-04 | Terminated(stopped due to Lack of enrollment and patient interest in study) | ||
| The Effect of Thoracolumbar Paravertebral Block or Intravenous Lidocaine and Ketamine Versus Standard Care on Acute and Chronic Pain After Inguinal Herniorrhaphy [NCT00720330] | 12 participants (Actual) | Interventional | 2008-07-31 | Terminated(stopped due to Enrollment challenges prohibited study progression.) | |||
| Effect of Ultrasonography Guided Transversus Abdominis Plane Block to Intraoperative Anesthesia in Children: Randomized Controlled Study [NCT02990975] | 60 participants (Anticipated) | Interventional | 2016-12-31 | Active, not recruiting | |||
| Effect of Ketamin+Propofol Mixture on Postoperative Recovery [NCT04761159] | Phase 4 | 112 participants (Actual) | Interventional | 2021-02-15 | Completed | ||
| Intraoperative Use of Ketamine for Awake Deep Brain Stimulation (DBS) Surgery Compared to Standard Procedure [NCT04716296] | 35 participants (Actual) | Interventional | 2021-01-01 | Active, not recruiting | |||
| Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures [NCT03781817] | Phase 4 | 40 participants (Actual) | Interventional | 2019-09-09 | Terminated(stopped due to Transition/change of primary investigators) | ||
| The Effect of Ketamine in The Prevention of Hypoventilation in Patients With and Without a Positive Berlin Questionnaire Undergoing Deep Sedation [NCT01535976] | 54 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| Comparison of Analgesic Effects of Magnesium Sulphate and Ketamine Added to 0.5% Bupivacaine for Erector Spinae Plane Block in Patients Undergoing Video-assisted Thoracoscopic Surgery [NCT05855798] | Phase 4 | 60 participants (Actual) | Interventional | 2023-05-10 | Completed | ||
| The Effect of Esketamine Combined With Pregabalin on Chronic Postsurgical Pain in Patients After Craniotomy. [NCT05160493] | Phase 2/Phase 3 | 246 participants (Anticipated) | Interventional | 2021-12-20 | Recruiting | ||
| The Effect of Ketamine on Immune Function and Prognosis in Patients Undergoing Colorectal Cancer Resection [NCT03273231] | 100 participants (Anticipated) | Interventional | 2017-09-01 | Recruiting | |||
| A Comparison of Gabapentin and Ketamine in Acute and Chronic Pain After Inguinal Hernia Repair: a Prospective Randomized Study [NCT04700592] | 60 participants (Actual) | Interventional | 2020-10-02 | Completed | |||
| phase2 Study of Prevention of Complications of Strabismus Surgery [NCT00478907] | Phase 2 | 300 participants (Actual) | Interventional | 2004-03-31 | Completed | ||
| Efficacy of Low Analgesic Doses of Ketamine Associated With Opioids in Refractory Cancer Pain Treatment [NCT00484484] | Phase 3 | 100 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| An Open Label, Single Center Study to Assess the Pharmacokinetics, Safety and Tolerability of Multiple Administrations of 30 mg PMI-150 (Intranasal Ketamine) in Healthy Adult Volunteers [NCT00519987] | Phase 1 | 18 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| Pain Free Laceration Repairs Using Intra-nasal Ketamine: A Dose Escalation Clinical Trial [NCT03053947] | Phase 2 | 42 participants (Actual) | Interventional | 2017-02-16 | Completed | ||
| Intranasal Midazolam Versus Intranasal Ketamine to Sedate Newborns for Intubation in Delivery Room. [NCT01517828] | Phase 3 | 62 participants (Actual) | Interventional | 2012-01-31 | Active, not recruiting | ||
| Prevention of Post-Mastectomy Pain With Perioperative Ketamine Administration: A Randomized, Placebo-controlled Trial [NCT03090776] | Early Phase 1 | 200 participants (Anticipated) | Interventional | 2017-07-01 | Recruiting | ||
| Biomarker Study: Impact of Single Doses of LY2979165 and LY2140023 on the Ketamine-Challenge Pharmacological MRI Assay in Healthy Male Subjects [NCT01524237] | Phase 1 | 52 participants (Anticipated) | Interventional | 2012-04-30 | Completed | ||
| A Randomised, Controlled Trial to Investigate the Effect of a Four Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. [NCT05973851] | Phase 3 | 418 participants (Anticipated) | Interventional | 2023-11-01 | Not yet recruiting | ||
| Effect of Perioperative Electroacupuncture With Tramadol and Ketamine on Postoperative Analgesia in Prostatectomy: a Randomized Placebo-controlled Trial [NCT01526525] | Phase 4 | 70 participants (Actual) | Interventional | 2009-07-31 | Completed | ||
| Ketamine-propofol Versus Ketamine Alone for Procedural Sedation in Adults : a Blinded, Randomized Controlled Trial [NCT01544725] | Phase 4 | 150 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| A Randomized Controlled Trial of the N-methyl-D-aspartate (NMDA) Receptor Antagonist Ketamine in Comorbid Depression and Alcohol Dependence. [NCT01551329] | Phase 1 | 5 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| A Double-blind, Randomized, Placebo-controlled, Parallel Group, Dose Frequency Study of Ketamine in Subjects With Treatment-resistant Depression [NCT01627782] | Phase 2 | 68 participants (Actual) | Interventional | 2012-08-06 | Completed | ||
| [NCT00115102] | Phase 4 | 20 participants | Interventional | 2004-03-31 | Completed | ||
| Comparing the Effect of Ketamine and Magnesium Sulfate Gargling With Placebo on Post-operative Sore Throat: A Randomized Controlled Trial [NCT04705948] | 60 participants (Actual) | Interventional | 2020-10-07 | Completed | |||
| Naturalistic Study of Ketamine in the Treatment of Depression: Suicide Risk Assessment and Serum Measurements of SIRT3, suPAR, hsCRP, Interleukin 6, Complete Blood Count, Leptin, Lipid Profile and Blood Glucose [NCT05249309] | 90 participants (Anticipated) | Observational [Patient Registry] | 2021-05-01 | Active, not recruiting | |||
| Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive Crisis (AKTSS) [NCT03296345] | Phase 2 | 62 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| The Effect of Ketamine and Dexmedetomidine on the Postoperative Cognitive Dysfunction After Cataract Surgery: Randomized Controlled Double-blinded Study [NCT04730596] | 90 participants (Actual) | Interventional | 2021-02-01 | Completed | |||
| A Combination Study With Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain in the Emergency Department [NCT03959852] | Phase 4 | 6 participants (Actual) | Interventional | 2019-11-18 | Terminated(stopped due to Residency completed.) | ||
| The Effect of Introperative Ketamine and Lidocaine Infusion on Postoperative Opioid Consumption in Posterior Spinal Fusion Surgery - Double-Blind Randomized Controlled Study [NCT04711668] | 75 participants (Actual) | Interventional | 2019-05-29 | Completed | |||
| Randomized Controlled Trial of Subanesthetic Intravenous Ketamine Infusion in Conjunction With Continuous Epidural Infusion for Treatment of Refractory Complex Regional Pain Syndrome [NCT02094352] | Phase 2 | 3 participants (Actual) | Interventional | 2014-03-24 | Terminated(stopped due to The study was unable to enroll efficiently despite trying various technique.) | ||
| Department of AnesthesiologyJinling Hospital, Nanjing University School of Medicine, Nanjing, China [NCT01573741] | Phase 1/Phase 2 | 35 participants (Anticipated) | Interventional | 2012-02-29 | Recruiting | ||
| The Effects of Subanesthetic Ketamine on Respiratory Stimulation and Transpulmonary Pressures in Mechanically Ventilated Critically Ill Patients [NCT01969227] | 15 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| The Use of Topical Baclofen, Amitriptyline HCI, and Ketamine (BAK) in a PLO Gel vs. Placebo for the Treatment of Chemotherapy Induced Peripheral Neuropathy: A Phase III Randomized Double-Blind Placebo Controlled Study [NCT00516503] | Phase 3 | 208 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery: A Randomized, Double-blind, Placebo-controlled Trial [NCT04220489] | Phase 2 | 2 participants (Actual) | Interventional | 2019-12-17 | Completed | ||
| Ultrasonography Guided Ilioinguinal /Iliohypogastric Block Versus Transversus Abdominis Plane Block in Intraoperative Anesthesia in Children - Randomized Controlled Study [NCT02991053] | 100 participants (Anticipated) | Interventional | 2016-12-31 | Active, not recruiting | |||
| The Interest of the Xylocaine® and Ketamine on the Per and Postoperative Management of Acute and Chronic Postoperative Pain After Colectomy by Laparoscopy [NCT02969733] | Phase 2/Phase 3 | 135 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| [NCT00209872] | Phase 4 | 60 participants (Anticipated) | Interventional | 2005-10-31 | Not yet recruiting | ||
| The Prevention of Delirium and Complications Associated With Surgical Treatments Multi Center Clinical Trial [NCT01690988] | Phase 3 | 746 participants (Actual) | Interventional | 2014-02-01 | Completed | ||
| Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion [NCT00146926] | Phase 3 | 200 participants | Interventional | 2005-09-30 | Active, not recruiting | ||
| The Use of Ketamine as Rescue Analgesia in the Recovery Room Following Opioid Administration. A Double-blind Randomised Trial in Postoperative Patients. [NCT00163969] | Phase 4 | 40 participants | Interventional | 2002-04-30 | Completed | ||
| Effect of S-ketamine in Cesarean Section Combined Anesthesia [NCT05414006] | Phase 4 | 120 participants (Actual) | Interventional | 2022-06-14 | Completed | ||
| Effect Of Ketamine Infusion On Oxygenation And Ventilation Mechanics In Patients With Chronic Obstructive Pulmonary Disease Applied One Lung Ventilation [NCT02962999] | Phase 4 | 30 participants (Actual) | Interventional | 2017-01-31 | Completed | ||
| MK III Trial: Analgesic Effect in Children of Low-Dose Ketamine for Mucositis Treated by Patient-Controlled Analgesia With Morphine [NCT00224692] | Phase 3 | 50 participants | Interventional | 2003-02-28 | Terminated | ||
| Pilot Study to Evaluate the Effectiveness of a Mixture of Ketamine / Lidocaine Administered by Mesotherapy in the Management of Neuropathic Pain in Complex Regional Pain Syndrome Type 1 (CRPS1). A Monocentric Randomized and Controlled Clinical Study [NCT04650074] | Phase 2/Phase 3 | 36 participants (Anticipated) | Interventional | 2021-11-05 | Recruiting | ||
| Quelling of Excitotoxicity in Acute Stroke With Ketamine [NCT03223220] | Phase 2/Phase 3 | 120 participants (Anticipated) | Interventional | 2024-07-01 | Not yet recruiting | ||
| Comparison Between Ketamine and Tramadol for Pain Management After Major Upper Abdominal Surgery [NCT02499341] | 42 participants (Actual) | Interventional | 2011-07-31 | Completed | |||
| Evaluation of Multimodal Preemptive Analgesia in Major Pediatric Abdominal Cancer Surgeries [NCT03580980] | 90 participants (Actual) | Interventional | 2015-04-01 | Completed | |||
| Biomarker Assessment of Glutamatergic Target Engagement [NCT02134951] | Phase 4 | 65 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| A Randomized, Controlled Trial of Intravenous Sub-dissociative Ketamine at Two Doses for Analgesia in the Emergency Department [NCT03714620] | Phase 4 | 98 participants (Actual) | Interventional | 2018-10-15 | Completed | ||
| Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy: a Pilot Study [NCT02987985] | Phase 3 | 50 participants (Actual) | Interventional | 2017-10-15 | Completed | ||
| A Phase 0, Double-Blind, Randomized, Placebo-Controlled, Crossover Study to Assess Ketamine-induced Changes in ERP Biomarkers in Healthy Volunteers [NCT04928703] | Early Phase 1 | 33 participants (Actual) | Interventional | 2022-05-26 | Completed | ||
| Efficacy and Safety of Deksmedetomidine-propofol or Ketamine-propofol [NCT04399226] | 60 participants (Actual) | Observational [Patient Registry] | 2019-10-18 | Completed | |||
| Effect of S-ketamine on Depressed Patients Undergoing Electroconvulsive Therapy-a Randomized, Double-blind, Controlled Clinical Study [NCT04399070] | 150 participants (Anticipated) | Interventional | 2020-08-01 | Not yet recruiting | |||
| "THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department" [NCT03081416] | Phase 3 | 80 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| Dose Response Study of Patient Controlled Analgesia (PCA) of S-ketamine in Orthopaedic Spine Surgery Patients [NCT02994173] | Phase 4 | 100 participants (Actual) | Interventional | 2017-02-01 | Completed | ||
| The Analgesic Effect of Combined Treatment With Intranasal S-Ketamine and Intranasal Midazolam Compared With Morphine Patient Controlled Analgesia in Spinal Surgery Patients [NCT01275547] | Phase 2/Phase 3 | 22 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Comparison of Sub-dissociative Dose Intranasal Ketamine to Intranasal Fentanyl for Treatment of Moderate to Severe Pain in Pediatric Patients Presenting to the Emergency Department: a Prospective, Randomized, Double-blind Study [NCT02388321] | Phase 4 | 22 participants (Actual) | Interventional | 2015-05-01 | Terminated(stopped due to Patients meeting inclusion criteria was low, and PI went to another institution.) | ||
| Low-Dose Intravenous Ketamine for Adolescents With Depression and Suicidal Ideation in the Emergency Department: A Randomized Placebo-Controlled Trial [NCT05217706] | Early Phase 1 | 30 participants (Anticipated) | Interventional | 2022-03-01 | Recruiting | ||
| Comparison Study of Analgesic Effects for Dexmedetomidine-fentanyl vs Dexmedetomidine-ketamine in Femur Proximal Fracture Patients [NCT02150759] | 46 participants (Actual) | Interventional | 2014-05-31 | Completed | |||
| Ketamine Efficacy for Acute Severe Bronchospasm in Mechanically Ventilated-critically Ill Patients: a Randomized Controlled Trial [NCT03000413] | Phase 2/Phase 3 | 90 participants (Anticipated) | Interventional | 2015-08-31 | Recruiting | ||
| Effects of Ketamine on Recovery From Bariatric Surgery [NCT01724983] | Phase 3 | 90 participants (Anticipated) | Interventional | 2012-06-30 | Active, not recruiting | ||
| Sedation During Muscle Biopsy in Patients With Duchenne Muscular Dystrophy [NCT01645098] | 53 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| The Effect of Ketamine on Reducing Cue Reactivity in Cocaine Users [NCT01790490] | Phase 2 | 8 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| Efficacy of Adding Ketamine to Levobupivacaine in Paravertebral Block on Acute and Chronic Pain in Thoracotomy: a Randomized Controlled Double-blinded Trial [NCT06011746] | Phase 4 | 60 participants (Anticipated) | Interventional | 2023-08-30 | Recruiting | ||
| Assessment of Three Regimens of Ketamine Infusion in Complex Regional Pain Syndrome: Randomized Prospective Comparative Study [NCT05997134] | Phase 4 | 75 participants (Anticipated) | Interventional | 2023-08-30 | Recruiting | ||
| Ketamine-Assisted Psychotherapy Viability in Treating Cancer-Related Emotional Distress [NCT05344625] | Early Phase 1 | 15 participants (Anticipated) | Interventional | 2023-12-15 | Not yet recruiting | ||
| Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department: A Prospective, Randomized, Double-Blind Study [NCT01835262] | Phase 4 | 90 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| An Open-Label and Double-Blind Study to Investigate Evoked Potentials as Markers of Ketamine-induced Cortical Plasticity in Subjects With Major Depressive Disorder [NCT01957410] | Phase 2 | 13 participants (Actual) | Interventional | 2014-02-28 | Terminated(stopped due to Clinical Team decision to terminate the study after the results from Cohort 1 did not support conducting Cohort 2.) | ||
| The Effects of Subanesthetic S-ketamine on Postoperative Delirium and Cognitive Function in the Elderly Undergoing Non-cardiac Thoracic Surgery: a Protocol for Randomized, Double-blinded, placebo-and Positive-controlled, Non-inferiority Trial [NCT05242692] | Early Phase 1 | 780 participants (Anticipated) | Interventional | 2022-03-10 | Recruiting | ||
| Role of CYP2B6 Polymorphisms in Ketamine Metabolism and Clearance [NCT01988922] | 30 participants (Actual) | Interventional | 2013-11-30 | Completed | |||
| Randomized Controlled Trial of Intranasal Ketamine vs. Intranasal Midazolam in Individuals With Obsessive Compulsive Disorder (OCD) [NCT02206776] | Phase 2 | 2 participants (Actual) | Interventional | 2014-09-30 | Terminated(stopped due to poor tolerability and low enrollment rate) | ||
| A Comparative Evaluation of Nebulized Dexmedetomidine and Nebulized Ketamine as a Premedication in Pediatric Surgeries [NCT05719506] | Phase 4 | 60 participants (Actual) | Interventional | 2021-07-21 | Completed | ||
| Imaging SV2A in Mood Disorders [NCT02734602] | 130 participants (Anticipated) | Interventional | 2016-04-30 | Recruiting | |||
| TIVA With Ketofol Versus Lidoketofol for Short-term Anesthesia on Pediatric Patients; Effects on Recovery [NCT04467424] | Phase 2 | 200 participants (Actual) | Interventional | 2020-06-20 | Completed | ||
| Modulation of Long-term Memory by the Experience of Pain During Sedation With Anesthetics [NCT02515890] | Phase 1 | 32 participants (Actual) | Interventional | 2015-11-19 | Completed | ||
| Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum Depression [NCT04011592] | Phase 2 | 1 participants (Actual) | Interventional | 2019-03-04 | Terminated(stopped due to Recruitment not feasible) | ||
| Low-Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department Geriatric Population: A Prospective, Randomized, Double-Blind Study. [NCT02673372] | Phase 4 | 60 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| Analgesia Effects of Intravenous Ketamine After Spinal Anesthesia for Non-elective Cesarean Section [NCT03450499] | Phase 4 | 80 participants (Actual) | Interventional | 2018-04-01 | Completed | ||
| The Effect of Gabapentin, Low Dose Ketamine, Paracetamol, NSAID and Dexamethasone on Pain and Opioid Requirements in Patients Scheduled for Primary Total Hip Replacement [NCT00236223] | Phase 4 | 48 participants (Actual) | Interventional | 2005-10-31 | Terminated(stopped due to Structural changes that stopped the type of operations used in the study) | ||
| Ketamine and Postoperative Analgesia in Children [NCT00200564] | Phase 4 | 74 participants (Anticipated) | Interventional | 2004-02-29 | Recruiting | ||
| Possible Neuroprotective Effects of Ketamine in Children With Severe Traumatic Brain Injury [NCT00556387] | Phase 2 | 0 participants (Actual) | Interventional | 2008-12-31 | Withdrawn(stopped due to This study has been withdraw from the IRB. The PI has transferred to another university. The IND was transferred.) | ||
| A Pilot Study on the Effects of Intravenous Ketamine on Acute Pain Crisis in Patients With Sickle Cell Disease [NCT00252122] | Phase 4 | 3 participants (Actual) | Interventional | 2004-06-30 | Terminated(stopped due to Recruitment was very slow.) | ||
| A Safe Ketamine-Based Therapy for Treatment Resistant Depression [NCT01179009] | 20 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| A Randomized, Participant- and Investigator Blind, Double Dummy, Placebo- and Comparator-controlled, Single Ascending Dose and Parallel-group Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Different Modes of (S) Ke [NCT03808259] | Phase 1 | 96 participants (Actual) | Interventional | 2018-12-20 | Completed | ||
| Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSD: A Pilot Study [NCT04889664] | Phase 2 | 16 participants (Actual) | Interventional | 2021-06-04 | Completed | ||
| [NCT00300794] | Phase 4 | 60 participants | Interventional | 2003-02-28 | Completed | ||
| Efficacy of a Polyamine-free Diet Associated or Not With Ketamine on Early and Late Hyperalgesia After Breast Cancer Surgery [NCT00304850] | Phase 2 | 160 participants (Anticipated) | Interventional | 2006-03-31 | Completed | ||
| Study of the Efficacity of the Systemic Ketamine for the Improvement of Post-Operative Analgesia After ORL Carcinological Surgery at the Alcohol-Dependent Patient. [NCT00329394] | Phase 3 | 56 participants (Anticipated) | Interventional | 2006-04-30 | Suspended | ||
| Intranasal Ketamine for Procedural Sedation in Pediatric Laceration Repair [NCT00451724] | Phase 2 | 45 participants (Anticipated) | Interventional | 2007-05-31 | Completed | ||
| Ketamine for the Treatment for Alcohol Use Disorder in the Emergency Department: A Pilot Double-blind, Placebo-controlled Randomized Clinical Trial [NCT05661669] | Phase 2 | 50 participants (Anticipated) | Interventional | 2023-10-25 | Recruiting | ||
| Intranasal Ketamine In the Treatment of Pediatric Bipolar Disorder [NCT01504659] | Phase 2/Phase 3 | 5 participants (Actual) | Interventional | 2012-07-31 | Terminated(stopped due to Administrative issues) | ||
| The Effect of Low Dose Intra-operative Ketamine on Closed-loop Controlled General Anesthesia [NCT03009409] | Phase 1 | 60 participants (Actual) | Interventional | 2018-03-13 | Completed | ||
| A Single-center, Single-dose, Double-blind, Randomized, Placebo- and Active-controlled Crossover Study to Evaluate the Abuse Potential of TC-5214 in Healthy Recreational Polydrug Users [NCT01500018] | Phase 1 | 0 participants (Actual) | Interventional | 2012-01-31 | Withdrawn(stopped due to Sponsor decision to withdraw.) | ||
| The Effect of Small-dose Ketamine on Depression of Respiratory and Cardiac Functions Caused by Propofol in Pediatric Cardiac Catheterization [NCT01501786] | 150 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) [NCT03113968] | Phase 2/Phase 3 | 403 participants (Actual) | Interventional | 2017-04-07 | Completed | ||
| Role of Adding Dexmedetomidine, Ketamine and Magnesium Sulphate to Caudal Block as Preemptive Analgesia in Hypospadias Repair in Pediatrics: a Randomized Double-blinded Trial [NCT05837000] | Phase 4 | 75 participants (Anticipated) | Interventional | 2023-05-15 | Recruiting | ||
| Changes in Striatal [11C]ORM-13070 Binding Elicited by Changing Levels of Endogenous Noradrenaline - a PET Study in Healthy Human Subjects [NCT01794975] | Phase 1 | 8 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| Assessment of Analgesic Effect of Ketamine Vs Ketamine Magnesium Infusion and Their Effect on Postoperative Morphine Consumption After Surgical Nephrectomy [NCT05596669] | Phase 1 | 100 participants (Actual) | Interventional | 2021-09-01 | Completed | ||
| Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial [NCT05233566] | Phase 3 | 32 participants (Actual) | Interventional | 2022-04-25 | Completed | ||
| A Pilot Study of Ketamine Sedation Initiated Early After Aneurysmal Subarachnoid Hemorrhage: Effect on Vasospasm, Delayed Cerebral Ischemia, and Functional Outcomes [NCT05032118] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2023-04-27 | Withdrawn(stopped due to Institution change, no IRB approval) | ||
| Effects of S-ketamine and Continuous Iliac Fascia Space Block on Perioperative Neurological Cognitive Impairment and Postoperative Rehabilitation in Elderly Patients With Hip Fracture [NCT05304559] | 108 participants (Anticipated) | Interventional | 2022-03-26 | Recruiting | |||
| Comparison of Outcomes During MRI Sedation With Midazolam-dexmedetomidine Versus Ketamine-dexmedetomidine [NCT02129426] | 21 participants (Actual) | Interventional | 2014-08-31 | Terminated(stopped due to Unable to recruit the adequate number of subjects) | |||
| Ketamine Versus Fentanyl for Surgical Abortions: A Randomized Controlled Noninferiority Trial [NCT04871425] | Phase 4 | 110 participants (Actual) | Interventional | 2021-04-27 | Completed | ||
| Developing Anesthesia as PTSD Therapy [NCT01736020] | Phase 1 | 293 participants (Actual) | Interventional | 2009-09-30 | Active, not recruiting | ||
| A Randomized, Subject And Investigator Blinded, Sponsor Open Placebo Controlled, 2 Way, Crossover Phase 1b Study To Examine The Effects Of PF-04958242 On Ketamine Induced Cognitive Impairment In Healthy Male Volunteers [NCT01749098] | Phase 1 | 29 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| An Exploratory, Blinded, Randomized, Placebo-controlled Study in Subjects With Depressive Disorder to Investigate the Effect of Minocycline on Relapse After Successful Intravenous Ketamine/Minocycline-induced (Partial) Symptoms Response [NCT01809340] | Phase 2 | 29 participants (Actual) | Interventional | 2013-06-30 | Terminated(stopped due to study team decision because of IP supply issue and necessary amendment to protocol) | ||
| Effects of Intraoperative Low-dose Ketamine on Incidence of Postpartum Depression in Parturients With Prenatal Depression Undergoing Cesarean Delivery: Blind Test, Randomized, Placebo-controlled Trial [NCT03336541] | Phase 4 | 64 participants (Actual) | Interventional | 2017-11-23 | Completed | ||
| Treatment of Thalamocortical Dysrhythmia Using External Neuromodulation to Facilitate the Therapeutic Effect of Ketamine. [NCT01816958] | 35 participants (Actual) | Observational | 2011-01-31 | Completed | |||
| Efficacy of Ketamine and Magnesium Association in the Postoperative Pain After Liposuction and Lipoabdominoplasty: Prospective, Randomized and Blinded Study [NCT02450214] | 63 participants (Actual) | Interventional | 2015-06-30 | Completed | |||
| Low Dose Intraoperative Intravenous Ketamine in Combination With Multilevel Paravertebral Block for Post Video-assisted Thoracic Surgery Pain: a Randomized Study [NCT03280017] | Phase 4 | 32 participants (Actual) | Interventional | 2017-09-25 | Completed | ||
| Effect of Ketamine Addition to Lidocaine for Postoperative Pain Management in Rhinoplasty [NCT01827020] | Phase 4 | 90 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Modifying Virtual Reality Analgesia With Low-Dose Pain Medication [NCT01840774] | 60 participants (Anticipated) | Interventional | 2013-04-30 | Recruiting | |||
| Effects of Low Doses of Ketamine on Postoperative Quality of Recovery After Total Intravenous Anesthesia [NCT02571153] | Phase 4 | 135 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Effects of Opioid Requirements With Scheduled Intranasal Ketamine During Admission for Traumatic Pain [NCT05671913] | Early Phase 1 | 0 participants (Actual) | Interventional | 2023-01-01 | Withdrawn(stopped due to Funding not acquired to run the study.) | ||
| Intranasal Ketamine Versus Subcutaneous Ketamine for Treatment of Post Traumatic Acute Pain in the Emergency Department [NCT05229055] | Phase 2/Phase 3 | 1,000 participants (Anticipated) | Interventional | 2023-04-15 | Recruiting | ||
| Ketamine + Mindfulness for Depression [NCT05168735] | Phase 1/Phase 2 | 43 participants (Actual) | Interventional | 2022-02-01 | Completed | ||
| Randomized Blinded Three Arm Trial of Propofol, 1:1 Combination of Propofol and Ketamine, and 4:1 Combination of Propofol and Ketamine for Procedural Sedation in the Emergency Department [NCT01260662] | Phase 4 | 271 participants (Actual) | Interventional | 2010-11-30 | Completed | ||
| Micro-Dose, Macro-Impact: Leveraging Psychedelics in Frontline Healthcare Workers During the COVID-19 Pandemic [NCT04769297] | Phase 4 | 30 participants (Actual) | Interventional | 2020-04-15 | Active, not recruiting | ||
| Intravenous Ketamine in the Treatment of Obsessive-Compulsive Disorder [NCT01371110] | Phase 1/Phase 2 | 3 participants (Actual) | Interventional | 2012-06-30 | Terminated(stopped due to no funding) | ||
| Ketamine for Severe Adolescent Depression: Intermediate-term Safety and Efficacy [NCT03889756] | Phase 2/Phase 3 | 3 participants (Actual) | Interventional | 2019-07-17 | Terminated(stopped due to No more funding available to continue since we could not recruit throughout the pandemic.) | ||
| Combination Use of Intravenous Ketamine-midazolam as a Sedative Agent in Endoscopic Retrograde Cholangiopancreatography ; A Randomized Control Trial [NCT06111872] | Phase 2 | 90 participants (Anticipated) | Interventional | 2023-07-18 | Recruiting | ||
| Hydromorphone PCA or Hydromorphone PCA With Ketamine for Acute Postoperative Pain Relief in Opioid-Dependent Chronic Pain Patients [NCT01591382] | Phase 4 | 64 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| Facilitating the Behavioral Treatment of Cannabis Use Disorder [NCT02946489] | Phase 1 | 8 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| A Double-Blind, Placebo-Controlled Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD) [NCT03149991] | Phase 4 | 51 participants (Actual) | Interventional | 2017-09-14 | Completed | ||
| Ketamine Versus Etomidate for Sedation of Emergency Department Patients During Rapid Sequence Intubation [NCT01823328] | Phase 4 | 143 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Effect of Single Dose Ketamine and Magnesium on Postoperative Pain in Patients Undergoing Bariatric Surgery [NCT02334059] | 108 participants (Actual) | Interventional | 2015-11-30 | Completed | |||
| Ketamine For Acute Treatment of Pain in Emergency Department [NCT02306759] | Phase 4 | 60 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Comparison of Prophylactic Use of Dexmedetomidine and Ketamine for Prevention of Shivering After Spinal Anesthesia [NCT05718011] | Phase 4 | 116 participants (Actual) | Interventional | 2021-02-20 | Completed | ||
| Ketamine for Treatment of Multiple Sclerosis-related Fatigue [NCT03500289] | Phase 1/Phase 2 | 18 participants (Actual) | Interventional | 2018-08-10 | Completed | ||
| Analgesic Effect of Intraoperative Intravenous S-Ketamine During Total Knee Arthroplasty Surgery:A Randomized Controlled Clinical Trial [NCT05289050] | Phase 4 | 144 participants (Anticipated) | Interventional | 2022-04-19 | Recruiting | ||
| Medication-assisted Psychotherapy: Using Ketamine-enhanced Radically Open Dialectical Behavior Therapy (RO DBT) to Target Neural and Behavioral Mechanisms of Action in Emerging Adults With Moderate to Severe Depression [NCT06138691] | Phase 1 | 15 participants (Anticipated) | Interventional | 2023-10-04 | Recruiting | ||
| Comparison of Emergence/Dysphoric Reaction Frequency of Using Ketamine at 2 Different Doses in Interventional Sedation and Analgesia [NCT05786365] | 108 participants (Anticipated) | Observational | 2023-01-01 | Active, not recruiting | |||
| Comparison of Intravenous Push Dose of Low Dose Ketamine to Short Infusion of Low Dose Ketamine for Treatment of Moderate to Severe Pain in the Emergency Department: A Prospective, Randomized, Double-Blind Study [NCT02363270] | 48 participants (Actual) | Interventional | 2015-04-01 | Completed | |||
| Analgesic Efficacy of Adductor Canal Block With Bupivacaine Versus Bupivacaine and Ketamine in Total Knee Arthroplasty. [NCT05715437] | Phase 4 | 60 participants (Anticipated) | Interventional | 2023-03-31 | Not yet recruiting | ||
| Efficacy Of Magnesium Sulphate Versus Ketamine as an Adjuvant to Bupivacaine in Pectoral Nerve Block During Mastectomy : Comparative Controlled , Randomized Double-Blind Study [NCT05663801] | Phase 2 | 72 participants (Anticipated) | Interventional | 2023-02-28 | Not yet recruiting | ||
| Ketamine Plus Lithium as a Novel Pharmacotherapeutic Strategy in Treatment-Resistant Depression [NCT01880593] | Phase 2 | 34 participants (Actual) | Interventional | 2013-07-31 | Completed | ||
| Ketamine-Midazolam Versus Morphine-Midazolam for Continous Patient Sedation in Intensive Care Units in Uganda. A Randomised Controlled Trial. [NCT03407404] | Phase 2/Phase 3 | 124 participants (Actual) | Interventional | 2017-10-22 | Terminated(stopped due to Futility) | ||
| Intranasal Dexmedetomidine Plus Ketamine for Procedural Sedation in Children: an Adaptive Randomized Controlled Non-inferiority Multicenter Trial [NCT04195256] | Phase 2/Phase 3 | 400 participants (Anticipated) | Interventional | 2020-03-11 | Recruiting | ||
| Competition With Striatal [11C]ORM-13070 Binding by Atipamezole and Endogenous Noradrenaline - a PET Study in Healthy Human Subjects [NCT01435213] | Phase 1 | 10 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| Complexity-enhancing Drugs to Treat Disorders of Consciousness (DoC): a Ketamine Study [NCT05343507] | Phase 2/Phase 3 | 30 participants (Anticipated) | Interventional | 2022-05-01 | Recruiting | ||
| Ketamine Infusion for Rapid Reduction of Suicidality in Pediatrics: a Pilot Randomized Controlled Trial [NCT04955470] | Phase 1/Phase 2 | 96 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting | ||
| Analgesic Efficacy of Intravenous Perfusion of Lidocaine, Ketamine or a Combination After Laparotomy in a Placebo-controlled, Randomized, Double-blind Prospective Study [NCT01439399] | 52 participants (Actual) | Interventional | 2005-12-31 | Completed | |||
| A Study of Ketamine as an Antidepressant [NCT01441505] | Phase 2 | 42 participants (Anticipated) | Interventional | 2011-09-30 | Recruiting | ||
| IN Dexmedetomidine for Procedural Sedation in Pediatric Closed Reductions for Distal Forearm Fractures. Timmons Z MD, Feudale B MD Children Presenting to the ED With Distal Forearm Extremity Fractures Often Require Re-alignment Under Conscious Sedation. T [NCT03466242] | Early Phase 1 | 40 participants (Anticipated) | Interventional | 2018-05-01 | Not yet recruiting | ||
| Characterization of Comorbid Post-traumatic Stress Disorder and Major Depressive Disorder Utilizing Ketamine as an Experimental Medicine Probe [NCT04032301] | Phase 1 | 108 participants (Anticipated) | Interventional | 2019-09-30 | Recruiting | ||
| A Randomised, Controlled Trial to Investigate the Effect of an Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. [NCT05603104] | Phase 3 | 1,254 participants (Anticipated) | Interventional | 2023-08-01 | Not yet recruiting | ||
| Ketamine/Midazolam Premedication Versus Pre-extubation Ketofol. Effect on Emergence Agitation and Recovery Profile After Pediatric Adenotonsillectomy: A Randomized Comparative Study. [NCT06010927] | Phase 4 | 140 participants (Anticipated) | Interventional | 2023-08-25 | Recruiting | ||
| Remifentanil Plus Ketamine Versus Midazolam Plus Fentanyl for Dynamic Flexible Bronchoscopy: Randomized Double-blind Clinical Trial [NCT03613792] | Phase 4 | 0 participants (Actual) | Interventional | 2023-09-30 | Withdrawn(stopped due to Change in procedure means limited value for study question) | ||
| Mechanism of Analgesic Effect on Prolonged Continuous Theta Burst Stimulation [NCT05360030] | 45 participants (Actual) | Interventional | 2022-05-14 | Completed | |||
| Dexmedetomidine Versus Ketamine Versus Magnesium Sulfate for the Prevention of Emergence Agitation Following Sevoflurane Induced Anesthesia in Cardiac Catheterization in Pediatrics : A Prospective, Double-blinded, Randomized Controlled Study. [NCT06077539] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2023-09-20 | Recruiting | ||
| The Effect of a Regimen of Opioid Sparing Anesthesia on Postoperative Recovery [NCT05717361] | 60 participants (Anticipated) | Interventional | 2022-11-01 | Recruiting | |||
| Safety of Intranasal Ketamine for Reducing Uncontrolled Cancer Related Pain [NCT03146806] | Phase 1/Phase 2 | 10 participants (Actual) | Interventional | 2017-07-25 | Completed | ||
| Effect of Single Intravenous Ketamine Dose on Postoperative Pain Following Cesarean Section Under Spinal Anesthesia: A Randomized Control Clinical Trial. [NCT03018301] | Phase 2 | 80 participants (Anticipated) | Interventional | 2017-01-31 | Recruiting | ||
| Pharmacologic Attenuation of Ketamine Using Nitroprusside [NCT03102736] | Phase 2 | 40 participants (Actual) | Interventional | 2017-02-14 | Completed | ||
| A Phase II, Open-label Clinical Trial of Intranasal Ketamine for Depression in Patients With Cancer Receiving Palliative Care (INKeD-PC Study) [NCT03410446] | Phase 2 | 22 participants (Actual) | Interventional | 2018-07-16 | Completed | ||
| Ketamine as an Adjunctive Therapy for Major Depression - a Randomised Controlled Pilot Trial: The KARMA-Dep Trial [NCT03256162] | Phase 1 | 25 participants (Actual) | Interventional | 2017-09-07 | Completed | ||
| Electroencephalogram Studies of Induction and Recovery From Sevoflurane-Induced General Anesthesia [NCT03503578] | Phase 2 | 12 participants (Actual) | Interventional | 2018-05-01 | Completed | ||
| Conscious Dying/Conscious Living: Ketamine-Assisted Psychotherapy (KAP) for Patients at End of Life-A Pilot Study for Palliative and Hospice Care [NCT05214417] | Phase 2 | 120 participants (Anticipated) | Interventional | 2022-05-01 | Not yet recruiting | ||
| Intranasal Ketamine for Late-Life Depression and Suicidal Ideation [NCT02295787] | Phase 4 | 0 participants (Actual) | Interventional | 2015-07-31 | Withdrawn(stopped due to No funding) | ||
| Repeated Sub-anesthetic Ketamine to Enhance Prolonged Exposure Therapy in Post-traumatic Stress Disorder: A Proof-of-concept Study [NCT03960658] | Phase 1/Phase 2 | 12 participants (Actual) | Interventional | 2019-04-03 | Completed | ||
| Low Dose Ketamine Infusion for Comorbid Posttraumatic Stress Disorder and Chronic Pain Patients [NCT04322968] | Phase 3 | 41 participants (Actual) | Interventional | 2018-01-09 | Completed | ||
| Nasal Administration of Sufentanil+Ketamine for Procedure-related Pain in Children [NCT01047241] | Phase 2 | 50 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Effects of Pre-operative Pregabalin and Ketamine to Prevent Development of Phantom Pain in Patients Undergoing Lower Extremity Amputation [NCT02311777] | Phase 3 | 0 participants (Actual) | Interventional | 2015-05-15 | Withdrawn(stopped due to Preoperative period is very short time) | ||
| Comparison of Propofol Combine Ketamine Anesthesia and Propofol Anesthesia in Schizophrenia Electroconvulsive Therapy: A Randomized Controlled Trial [NCT03829124] | Phase 4 | 1 participants (Anticipated) | Interventional | 2019-05-24 | Not yet recruiting | ||
| Efficacy of S(+)-Ketamine Administered as a Continuous Infusion for the Control of Postoperative Pain: a Randomized Controlled Trial [NCT02421913] | Phase 4 | 42 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| A Comparative Study Between Intrathecal Dexmedetomidine VS Ketamine With Intrathecal Bupivacaine in Orthopedic Lower Limb Surgeries. [NCT05751304] | 100 participants (Anticipated) | Interventional | 2023-03-01 | Not yet recruiting | |||
| The Role of Ketamine and Magnesium in Post-operative Pain Control After Laparoscopic Surgery in Patients With Chronic Pelvic Pain Treated With Opioids: A Double-Blinded Randomized Control Trial. [NCT02940509] | Phase 1 | 20 participants (Actual) | Interventional | 2017-07-01 | Terminated(stopped due to Change in practice of medicine. There were no longer sufficient patients to enroll in the study that met criteria.) | ||
| Spontaneous and Oxytocin-induced Contractility After Exposure to Intravenous Anesthetic Agents: an In-vitro Study in Human Myometrium [NCT03852797] | 33 participants (Actual) | Interventional | 2019-03-28 | Completed | |||
| Ketamine for Acute Painful Crisis in Sickle Cell Disease Patients: Prospective Randomized Control Trial [NCT03431285] | 264 participants (Anticipated) | Interventional | 2018-01-01 | Recruiting | |||
| Administration of Intravenous NRX100 (Ketamine) vs Placebo Infusion for Rapid Stabilization of Acute Suicidal Ideation and Behavior in Patients With Bipolar Depression [NCT03396601] | Phase 3 | 150 participants (Anticipated) | Interventional | 2019-06-25 | Recruiting | ||
| [NCT01260649] | Phase 4 | 17 participants (Actual) | Interventional | 2010-11-01 | Terminated(stopped due to lack of funding to cover staff salary (clinician and research coordinator)) | ||
| The Role of Brief Potent Glutamatergic Modulation in Addressing Problem Drinking: a Randomized, Controlled Trial [NCT04084860] | Phase 2 | 120 participants (Anticipated) | Interventional | 2019-11-08 | Recruiting | ||
| Clinical Effects of Esketamine Induction Intubation Versus Conventional Induction Intubation in ICU Patients: a Single-center Randomized Clinical Trial [NCT05464979] | Phase 4 | 100 participants (Anticipated) | Interventional | 2022-08-01 | Recruiting | ||
| Evaluation of the Impact of the Use of Ketamine in Laparoscopic Surgery, Using the Quality of Recovery 15 Questionnaire. [NCT03724019] | Phase 4 | 127 participants (Actual) | Interventional | 2018-10-01 | Completed | ||
| Effects of Intraoperative Intravenous Ketamine on Chronic Pain After Mastectomy [NCT02729805] | Phase 4 | 135 participants (Anticipated) | Interventional | 2015-08-18 | Suspended(stopped due to Not enough patients) | ||
| Ketamine for Acute Suicidal Ideation in the Emergency Department: Randomized Controlled Trial [NCT01892995] | 53 participants (Anticipated) | Interventional | 2015-06-30 | Not yet recruiting | |||
| Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel [NCT05046184] | Phase 2 | 180 participants (Anticipated) | Interventional | 2022-05-05 | Recruiting | ||
| Lidocaine and Ketamine Levels in Plasma After Simultaneous Lidocaine/Ketamine Infusions. An Observational Assessment of Therapy Effects and Side-effects. [NCT05906121] | 15 participants (Anticipated) | Observational | 2023-05-16 | Recruiting | |||
| The Perinatal SMILES (Synergistic Multi-component Intervention to alLeviate dEpressive Symptoms) Case Series. Combining Ketamine and Interpersonal Psychotherapy to Improve Postpartum Mood [NCT06048263] | Phase 2/Phase 3 | 25 participants (Anticipated) | Interventional | 2023-12-01 | Not yet recruiting | ||
| Anesthesia for Upper Endoscopy and Colonoscopy in Cardiac Patients With Acute Anemia: Pretreatment With Low-dose Ketamine Can Reduce the Dose of Etomidate. A Randomized Clinical Trial. [NCT04857450] | 60 participants (Anticipated) | Interventional | 2020-11-20 | Recruiting | |||
| Safety and Efficacy Evaluation of S（+）-Ketamine for Postoperative Acute Pain in Adults in Perioperative Settings: A Multicenter, Randomized, Open-label, Active Controlled Pragmatic Clinical Trial [NCT04837170] | Phase 4 | 12,000 participants (Anticipated) | Interventional | 2021-05-01 | Not yet recruiting | ||
| Dyphenhidramine Effect on Prevention of Sevoflurane Induced Post Anesthesia Agitation in Pediatric [NCT02463929] | Phase 4 | 50 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| Efficacy of Ketamine Mouthwash in the Management of Oral and Pharyngeal Toxicity [NCT05331131] | Phase 2 | 56 participants (Anticipated) | Interventional | 2023-04-01 | Not yet recruiting | ||
| [NCT01535937] | Phase 1/Phase 2 | 55 participants (Actual) | Interventional | 2012-02-29 | Terminated(stopped due to An analysis demonstrated that running the final participants was unnecessary.) | ||
| Low Dose Ketamine (LDK) Versus Morphine for Acute Pain Control in the Emergency Department [NCT01538745] | Phase 4 | 45 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Case Series: A Sequenced Treatment Using a Modified Ketogenic Diet and Ketamine for Severe and Enduring Anorexia Nervosa [NCT04714541] | Phase 1 | 5 participants (Actual) | Interventional | 2021-04-12 | Completed | ||
| The Effect of Low-dose of S-ketamine Combined With Sufentanil for Postoperative Patient-controlled Intravenous Analgesia in Patients Following Cesarean Section [NCT05299866] | Phase 4 | 216 participants (Anticipated) | Interventional | 2022-04-12 | Recruiting | ||
| Efficacy of Rapid-Acting NMDA Antagonist for Treatment of Adolescent Depression and Anxiety Disorders [NCT02579928] | Phase 4 | 17 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| Randomized, Double-blind, Placebo Controlled Study on the Effect of a Single Postoperative Administration of Low Dose Ketamine After Gastric Bypass and Gastrectomy Surgeries [NCT02452060] | Phase 2/Phase 3 | 90 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| A Randomized Controlled Trial to Decrease Suicidal Thinking Using Ketamine [NCT02418702] | Phase 3 | 0 participants (Actual) | Interventional | 2016-08-31 | Withdrawn(stopped due to PI no longer at facility.) | ||
| Discharge Readiness After Propofol With or Without Esketamine for Outpatient Flexible Bronchoscopy: a Randomized, Controlled Study [NCT05643066] | Phase 4 | 246 participants (Anticipated) | Interventional | 2022-12-07 | Recruiting | ||
| A Randomized, Double-blind Comparison of the Effects of Dexmedetomidine and Ketamine on Oxidative Stress Markers in Patients Under Combined Spinal-epidural Anesthesia Under Lower Extremity Surgery [NCT05950555] | 90 participants (Actual) | Interventional | 2021-12-30 | Completed | |||
| Characterization of Electroencephalographic (EEG) Signatures of Chronic Pain Patients Receiving Intravenous Ketamine. [NCT05949554] | 50 participants (Anticipated) | Observational | 2023-09-30 | Not yet recruiting | |||
| Randomized Controlled Trial of Intranasal Ketamine Compared to Intranasal Fentanyl for Analgesia in Children With Suspected, Isolated Extremity Fractures in the Pediatric Emergency Department [NCT02521415] | Phase 2 | 87 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| Analgesic Effects of Topical Ketamine Mouthwash in Patients Receiving Chemoradiation or Radiotherapy for Head and Neck Cancer [NCT01653327] | Phase 2 | 11 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| The Role of Ketamine and Dexmedetomidine in Opioid-Sparing Analgesia and Sedation in Adult Patients After Cardiac Surgery. A Randomized Clinical Trial [NCT05474183] | 90 participants (Actual) | Interventional | 2022-08-05 | Completed | |||
| Comparison Of Dexmedetomidine And Ketamine For Control Of Shivering In Vaginal Hysterectomy Proceeded Under Spinal Anesthesia [NCT05481281] | Phase 3 | 104 participants (Anticipated) | Interventional | 2022-08-01 | Not yet recruiting | ||
| A Randomized Controlled Trial of Intranasal Sub-dissociative Dosing of Ketamine Compared to Intranasal Fentanyl for Treatment of Pain Associated With Acute Extremity Injuries in Children [NCT02778880] | Phase 3 | 90 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| Prospective Randomised Double Blind Trial of Ketiapine and Olanzapine Comparative Efficacy for Fast Sedation of Severely Agitated Patients in Emergency Psychiatric Ward [NCT03216941] | Phase 4 | 500 participants (Actual) | Interventional | 2015-01-01 | Completed | ||
| Glutamatergic Modulation to Facilitate the Behavioral Treatment of Cocaine Use Disorders [NCT03344419] | Phase 3 | 150 participants (Anticipated) | Interventional | 2017-10-01 | Recruiting | ||
| Intravenous Sub-anesthetic Ketamine Treatment in Treatment-Resistant Depression [NCT02360280] | Phase 2 | 62 participants (Actual) | Interventional | 2015-04-01 | Completed | ||
| Estimate the Efficiency of the Association of an Injection of Ketamine and the Venlafaxine in the Severe Major Depressive Disorder for Six Weeks. [NCT01557712] | Phase 3 | 25 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| The Effects of Sedatives on Tobacco Use Disorder [NCT03813121] | Phase 1/Phase 2 | 10 participants (Actual) | Interventional | 2019-06-01 | Completed | ||
| Combination of Anticholinergic and Glutamatergic Effects in Treatment-resistant Major Depressive Disorder. A Pilot Study [NCT01613820] | 0 participants (Actual) | Interventional | 2015-09-30 | Withdrawn(stopped due to Lack of funding) | |||
| Effect of Low-dose Ketamine on Postoperative Depressive Symptom in Patients Undergoing Intracranial Tumor Resection (PASSION) [NCT03086148] | Phase 2/Phase 3 | 84 participants (Actual) | Interventional | 2017-07-05 | Completed | ||
| A Randomized, Clinical Trial of Oral Midazolam Versus Oral Ketamine for Sedation During Laceration Repair. [NCT01925898] | Phase 4 | 60 participants (Anticipated) | Interventional | 2013-08-31 | Recruiting | ||
| Ketamine as a Sedation Adjunct for Endoscopic Procedures [NCT03461718] | Phase 2 | 66 participants (Actual) | Interventional | 2018-03-05 | Completed | ||
| A Randomized, Placebo-controlled, Concealed Allocation Comparison of Respiratory Depression and Coughing During Bronchoscopy With Dexmedetomidine-ketamine as an Adjunct to Fentanyl-midazolam Sedation [NCT01158820] | Phase 4 | 50 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| A Randomized, Placebo Controlled, Double-blind, Double-dummy, Three-way Crossover Trial to Investigate the Effect of Two Doses of BI 474121 on Ketamine Induced Cognitive Deficits in Healthy Male Subjects [NCT05451095] | Phase 1 | 0 participants (Actual) | Interventional | 2022-11-07 | Withdrawn(stopped due to Termination of project) | ||
| Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment on Alternate Week Days in Patients With Treatment Resistant Depression: A Double Blind Placebo Controlled Trial [NCT02522377] | 15 participants (Actual) | Interventional | 2015-08-31 | Completed | |||
| Dexmedetomidine Versus Ketamine to Facilitate Non-invasive Ventilation After Blunt Chest Trauma [NCT05175781] | 45 participants (Actual) | Interventional | 2022-01-18 | Completed | |||
| The Effect of a Regimen of Opioid Sparing Anesthesia on Postoperative Recovery [NCT05594407] | 60 participants (Anticipated) | Interventional | 2022-08-01 | Recruiting | |||
| Intravenous Ketamine in Treatment-Resistant Bipolar Depression [NCT00947791] | Phase 4 | 1 participants (Actual) | Interventional | 2009-07-31 | Terminated(stopped due to Change in available resources for study procedures) | ||
| Investigating Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine [NCT04977674] | Early Phase 1 | 27 participants (Actual) | Interventional | 2021-09-27 | Completed | ||
| Opioid-Free Pain Control Regiment Following Robotic Radical Prostatectomy: A Randomized Controlled Trial [NCT04939987] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2022-08-31 | Withdrawn(stopped due to PI left institution and study was not transferred to new PI) | ||
| Randomized Controlled Trial of Repeated-Dose Intravenous Ketamine for PTSD [NCT02397889] | Phase 2/Phase 3 | 30 participants (Actual) | Interventional | 2015-05-18 | Completed | ||
| A Randomized, Double-Blind, Placebo-Controlled Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse [NCT03539887] | Phase 3 | 33 participants (Actual) | Interventional | 2018-05-01 | Completed | ||
| Pilot Study: Ketamine for Acute Pain After Rattlesnake Envenomation [NCT05379179] | Phase 4 | 40 participants (Anticipated) | Interventional | 2022-06-20 | Enrolling by invitation | ||
| Ketamine Infusion for Social Anxiety Disorder [NCT02083926] | Early Phase 1 | 18 participants (Actual) | Interventional | 2015-01-02 | Completed | ||
| Dexmedetomidine Compared to Ketofol for Sedation in Paediatrics Undergoing Dental Procedures: a Comparative Study [NCT04678050] | Phase 1 | 40 participants (Actual) | Interventional | 2020-10-10 | Completed | ||
| The Sustained Effects of Ketamine [NCT02708849] | Phase 1 | 3 participants (Actual) | Interventional | 2015-06-30 | Terminated | ||
| Open-Label Intravenous Subanesthetic Ketamine for Adolescents With Treatment-Resistant Depression [NCT02078817] | Phase 2 | 14 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| Eliminating Use of Non Depolarizing Neuromuscular Blocking Agents to Reduce Postoperative Pulmonary Complications: A Multi-center, Randomized Control Trial [NCT03962725] | Phase 4 | 3 participants (Actual) | Interventional | 2019-08-07 | Terminated(stopped due to Study terminated due to lack of enrollment.) | ||
| Ketamine in Chronic Kid's (KiCK) Pain [NCT01755169] | Phase 2 | 7 participants (Actual) | Interventional | 2013-01-31 | Terminated(stopped due to Inability to enroll sufficient patients) | ||
| Anesthesia and Brain Functional Connectivity: An Analysis of fMRI Changes in Chronic Pain and Refractory Depression [NCT02196259] | 16 participants (Actual) | Interventional | 2008-02-29 | Terminated(stopped due to Funding cessation.) | |||
| Examining the Impact of Sirolimus on Ketamine's Antidepressant Effects [NCT02487485] | Phase 2 | 23 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| The Effect of Brief Potent Glutamatergic Modulation on Disordered Alcohol Use [NCT02539511] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| ACL Repair and Multimodal Analgesia [NCT01868425] | Phase 4 | 112 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| Pharmacokinetic Alterations During ECMO (Ketamine and Extracorporeal Membrane Oxygenation) [NCT01938079] | 20 participants (Actual) | Interventional | 2013-09-30 | Completed | |||
| A Randomized Placebo-Controlled Trial of Sub-Dissociative Ketamine for Treatment of Acute Migraine-Type Headache in the Emergency Department [NCT02697071] | 34 participants (Actual) | Interventional | 2016-02-29 | Completed | |||
| Neuroprotective Effects of ACTH4-10PRO8-GLY9-PRO10 on The Ketamine-Induced Neurotoxicity In Neonatal Rats: Increased BDNF Expression And BDNF Serum Concentrations [NCT05648526] | 42 participants (Actual) | Interventional | 2021-08-01 | Completed | |||
| Sub-dissociative Ketamine for the Management of Acute Pediatric Pain [NCT01951963] | Phase 4 | 77 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| Co-administration of Ketamine and Propofol for Upper Endoscopy in Children: a Dose-finding Study [NCT02295553] | Phase 4 | 56 participants (Actual) | Interventional | 2013-07-31 | Completed | ||
| A Comparison of S-ketamin, Dexmedetomidine, and Combination as Premedication in Children Undergoing ENT Surgery [NCT04757675] | Early Phase 1 | 320 participants (Actual) | Interventional | 2021-03-01 | Completed | ||
| Ketamine Effect on Recovery and Respiratory Outcomes After Laparoscopic Gastric Reduction: A Randomized, Double-Blinded, Placebo Controlled Study [NCT01997515] | Phase 4 | 80 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| A Naturalistic Study of Serial Infusion of Low-dose Ketamine for Treatment Resistant Depressive Disorders in an Academic Psychiatric Hospital: The UTHealth Ketamine Project [NCT02882711] | Phase 2 | 10 participants (Actual) | Interventional | 2016-11-07 | Terminated(stopped due to Increasing off-label practice of IV ketamine administration for treatment-resistant depression.) | ||
| Randomized Double Blind Comparison of Peri-Operative Standard Analgesia With Peri-Operative Lidocane, Ketamine, or Lidocane and Ketamine Combination, Infusion for Patients Undergoing Spine Surgery [NCT01983020] | Phase 3 | 46 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| Spinal Versus General Anesthesia With Popliteal and Adductor Canal Blocks for Ambulatory Foot and Ankle Surgery: A Double-Blinded Randomized Controlled Trial. [NCT02996591] | Phase 4 | 36 participants (Actual) | Interventional | 2017-01-31 | Completed | ||
| Comparison of Esketamine-Propofol and Fentanyl-Propofol on Haemodynamics in Elderly Patients [NCT05752409] | 120 participants (Anticipated) | Interventional | 2021-10-08 | Recruiting | |||
| Glutamatergic Mechanisms of Psychosis and Target Engagement: Aim2 [NCT05401227] | Phase 1 | 120 participants (Anticipated) | Interventional | 2022-10-15 | Suspended(stopped due to U.S. Department of Health and Human Services OHRP issued an FWA restriction on NYSPI research that included a pause of human subjects research as of June 23, 2023. This study will resume recruitment after OHRP has approved the resumption of research.) | ||
| A Pilot Study of the Use of Oral Ketamine for Treatment of Vaso-Occlusive Pain in Adolescents and Young Adults [NCT05378555] | Phase 3 | 10 participants (Anticipated) | Interventional | 2023-05-01 | Recruiting | ||
| Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies - the PATHFINDER II Study [NCT05279898] | 70 participants (Anticipated) | Interventional | 2023-02-28 | Recruiting | |||
| Neural Correlates of Anti-suiciDal rEsponse to kEtamine in Treatment Resistant biPolar dePression (DEEPP-Study) [NCT05177146] | 30 participants (Anticipated) | Interventional | 2022-05-04 | Recruiting | |||
| Safety and Clinical Effects of Intranasal Ketamine in Ultra-REsistant Depression (SURE-ECT Non Responders). Pilot Study [NCT05137938] | 25 participants (Actual) | Interventional | 2021-10-25 | Completed | |||
| Plasma Exosomal MicroRNAs as Promising Novel Biomarkers for Suicidality and Treatment Outcome [NCT02418195] | Phase 2 | 247 participants (Actual) | Interventional | 2015-04-20 | Completed | ||
| Novel Approach of Combined Lithium-Ketamine Therapy in Bipolar Depression: To Preserve Efficacy and Minimize Adverse Effects [NCT01768767] | Phase 2 | 0 participants (Actual) | Interventional | 2013-01-31 | Withdrawn(stopped due to No funding) | ||
| Opioid Sparing Anaesthesia Via Dexmedetomidine, Ketamine and Lidocaine Infusion for Prevention of Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgery [NCT04706897] | Phase 4 | 80 participants (Actual) | Interventional | 2021-01-15 | Completed | ||
| Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder [NCT05796791] | Early Phase 1 | 8 participants (Anticipated) | Interventional | 2023-05-02 | Recruiting | ||
| A Study of Human Multi-Sensory Integration: A Neurophysiologic Correlate of Conscious Perception [NCT03498391] | Phase 2 | 40 participants (Anticipated) | Interventional | 2018-07-30 | Suspended(stopped due to Due to the impact of COVID-19) | ||
| Comparison of Ketamine and Esketamine in Ambulatory Patients Treated for Fibromyalgia Syndrome in Pain Clinic. A Single-center, Prospective, Randomized, Double-blind, Crossover Study. [NCT04938713] | 50 participants (Anticipated) | Interventional | 2021-07-01 | Recruiting | |||
| Comparing the Effectiveness of Low-dose Ketamine With Morphine to Treat Pain in Patients With Long Bone Fractures [NCT02430818] | 13 participants (Actual) | Interventional | 2015-04-30 | Terminated(stopped due to were not able to enroll patients to a satisfactory level) | |||
| Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients [NCT02432456] | Phase 4 | 153 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [NCT02596022] | Phase 2 | 18 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Baseline Insular Dysfunction as a Predictor of Ketamine's Antidepressant Effects in Anxious Depression [NCT02544607] | Phase 4 | 25 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis [NCT02625181] | 27,034 participants (Actual) | Interventional | 2016-07-31 | Completed | |||
| Ketamine and Propofol Combination Versus Propofol for Upper Gastrointestinal Endoscopy [NCT02643979] | Phase 4 | 22 participants (Actual) | Interventional | 2016-01-01 | Terminated(stopped due to Lack of Enrollment) | ||
| Effect of Intraoperative Intravenous Ketamine Infusion on Postoperative Analgesia in Right Hepatectomy of Living Liver Donors [NCT05441150] | Phase 4 | 2 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting | ||
| Comparison of Low-dose Ketamine to Opioids in the Management of Acute Pain in Patients Presenting to the Emergency Department With Long Bone Fractures [NCT04061330] | Phase 2 | 0 participants (Actual) | Interventional | 2022-01-01 | Withdrawn(stopped due to Study was terminated prior to enrollment due to lack of funding) | ||
| Does a Ketamine Infusion Decrease Post Operative Narcotic Consumption After Gastric Bypass Surgery? [NCT03001843] | Phase 4 | 54 participants (Actual) | Interventional | 2017-02-22 | Completed | ||
| Nebulized Dexmedetomidine Combined With Ketamine Versus Nebulized Dexmedetomidine to Induce Preoperative Sedation and Attenuate Emergence Agitation in Children Undergoing Cleft Palate Repair Surgeries [NCT05821972] | Phase 4 | 60 participants (Anticipated) | Interventional | 2023-05-15 | Not yet recruiting | ||
| Anxiolysis for Emergency Department Procedures in Pediatric Patients Using Intranasal Ketamine Compared With Intranasal Midazolam: A Randomized Controlled Trial [NCT03043430] | Phase 4 | 10 participants (Actual) | Interventional | 2016-05-31 | Terminated(stopped due to Research manpower shortage) | ||
| A Randomized, Investigator and Subject-Blind, Placebo-Controlled, Single-Dose, 3-Period, Incomplete Block Cross-Over Study to Evaluate the Effects of Single Oral Administration of TAK-063 on Preventing Ketamine-Induced Brain Activity Changes as Well as Ps [NCT01892189] | Phase 1 | 27 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| A Comparison of Midazolam vs. Midazolam/Ketamine for Conscious Sedation in Patients Undergoing Phacoemulsification Under Topical Anesthesia [NCT03054103] | Phase 4 | 105 participants (Actual) | Interventional | 2016-05-03 | Completed | ||
| Ketamine: Its Effects on Suicidal Ideations and Inpatient Hospital Length of Stay [NCT02997722] | Phase 4 | 4 participants (Actual) | Interventional | 2017-03-02 | Terminated(stopped due to Staffing and space deficiencies prevented completion of the study.) | ||
| Comparison of Sedation, Pain, and Care Provider Satisfaction Between the Use of Intranasal Ketamine Versus Intranasal Midazolam and Fentanyl During Laceration Repair [NCT03528512] | Phase 4 | 5 participants (Actual) | Interventional | 2018-09-04 | Terminated(stopped due to Staffing for study was eliminated) | ||
| [NCT00376831] | Phase 4 | 91 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| The Role of Lamotrigine in Reducing Psychologic Side-Effect of Perioperative Ketamine Use [NCT03831854] | Phase 3 | 46 participants (Actual) | Interventional | 2019-01-24 | Completed | ||
| Intraoperative Low-dose Ketamine Infusion for Patients With Obstructive Sleep Apnea: A Prospective, Randomized, Controlled, Double-Blind Study [NCT03109418] | Phase 2/Phase 3 | 9 participants (Actual) | Interventional | 2016-06-02 | Terminated(stopped due to Recruitment challenges) | ||
| Multimodal Analgesia in Cardiac Surgery (Pilot Study) [NCT02734940] | Phase 4 | 3 participants (Actual) | Interventional | 2016-07-11 | Terminated(stopped due to Unable to find participants who met inclusion/exclusion criteria) | ||
| A Prospective, Randomized, Single Blinded Comparison of Intraoperative Ketamine Infusion Versus Placebo in Patients Having Spinal Fusion [NCT02424591] | Phase 4 | 46 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| "Ketamine / Propofol Admixture Ketofol at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial" [NCT02105415] | Phase 2/Phase 3 | 160 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| Ketamine and Dexametasone in the Management of Pain in Lumbar Arthrodesis [NCT04751175] | Phase 4 | 128 participants (Anticipated) | Interventional | 2013-07-04 | Recruiting | ||
| Clinical Predictors of Intravenous Ketamine Response in Treatment-Resistant Depression: A Randomized, Double-Blind, Midazolam-Controlled Pilot Study [NCT05625555] | Phase 3 | 40 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| Pharmacokinetics of Ketamine in Infants and Children [NCT00553839] | 21 participants (Actual) | Interventional | 2007-07-31 | Completed | |||
| Ketamine v. Ketorolac for Management of Generalized Tension Type Headache [NCT03221569] | Phase 4 | 60 participants (Anticipated) | Interventional | 2016-02-01 | Recruiting | ||
| Ketofol Versus Propofol in Urgent ERCP for Acute Cholangitis: A Randomized Controlled Trial [NCT04997967] | Phase 4 | 100 participants (Anticipated) | Interventional | 2020-07-01 | Recruiting | ||
| Comparing Dexmedetomidine, Ketamine and Dexmetedomidine-Ketamine Combination to Control Shivering During Regional Anaethesia [NCT03302351] | Phase 4 | 94 participants (Actual) | Interventional | 2017-10-01 | Completed | ||
| Ketamine and Neuropathic Pain [NCT02467517] | Phase 2 | 22 participants (Anticipated) | Interventional | 2015-11-30 | Recruiting | ||
| Precision Medicine With Ketamine for Older Adults With Treatment-resistant Depression: Pilot Study [NCT04504175] | Phase 4 | 25 participants (Actual) | Interventional | 2020-10-22 | Completed | ||
| Ketamine as Adjunctive Analgesic With Bupivacaine in Paravertebral Analgesia for Breast Cancer Surgery [NCT02462681] | Phase 1/Phase 2 | 90 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| Targeting mTOR/GSK3 With Lithium Augmentation to Enhance and Sustain Rapid Antidepressant Actions of Ketamine in Adults With Treatment-Resistant Depression: A Precision Medicine Approach for Psychiatry [NCT03290963] | Phase 2 | 0 participants (Actual) | Interventional | 2017-11-30 | Withdrawn(stopped due to Principal Investigator moved to Jacksonville, FL campus.) | ||
| Electroencephalographic Effects of Ketamine During Isoflurane Maintenance and Recovery [NCT03290495] | Phase 4 | 30 participants (Actual) | Interventional | 2017-09-30 | Completed | ||
| Endogenous Opioid Modulation by Ketamine [NCT03051945] | Phase 3 | 0 participants (Actual) | Interventional | 2019-08-31 | Withdrawn(stopped due to Unable to perform brain imaging) | ||
| Effect of S-ketamine Anesthetic on Inflammatory Response in Septic Patients Undergoing Abdominal Surgery:a Single Center, Randomized, Controlled Trial [NCT04873479] | 50 participants (Anticipated) | Interventional | 2021-05-10 | Recruiting | |||
| A Placebo-Controlled Crossover Trial of Intranasal Ketamine for the Treatment of Obsessive-Compulsive Disorder [NCT02234011] | Phase 2 | 1 participants (Actual) | Interventional | 2014-09-30 | Terminated(stopped due to Terminated due to difficulty in recruiting participants.) | ||
| Comparison of Lidocaine, Dexmedetomidine and Ketamine in Multimodal Analgesia Management Following Sleeve Gastrectomy Surgery: A Randomized Double-Blind Trial [NCT04836819] | 78 participants (Actual) | Interventional | 2021-04-08 | Completed | |||
| Bioavailability Study of Intranasal CT001 in Healthy Volunteers [NCT04807335] | Phase 1 | 14 participants (Actual) | Interventional | 2021-03-17 | Completed | ||
| The Use of S+Ketamine Versus Placebo During Target-Controlled Intravenous Anaesthesia to Reduce Morphine Consumption and Side Effects After Abdominal Hysterectomy: A Randomized Controlled Trial [NCT03231683] | Phase 2 | 90 participants (Actual) | Interventional | 2014-03-31 | Completed | ||
| Nasal Inhalation of Sevoflurane Versus Midazolm,Ketamine and Propofol For Pediatric Undergoing Upper Gastrointestinal Endoscopy [NCT05474937] | 74 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting | |||
| Dexametomedine Versus Ketamine as an Adjuvant in Ultrasound Guided Erector Spinae Block for Perioperative Thoracotomy Pain Control in Pediatrics Cardiothoracic Surgeries: A Randomized Controlled Trial [NCT05552391] | Phase 4 | 90 participants (Anticipated) | Interventional | 2022-09-01 | Recruiting | ||
| Baden PRIDe Trial - Baden Prevention and Reduction of Incidence of Postoperative Delirium Trial [NCT02433041] | Phase 4 | 200 participants (Actual) | Interventional | 2013-07-31 | Completed | ||
| A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients [NCT03714919] | Phase 2 | 10 participants (Actual) | Interventional | 2019-08-02 | Completed | ||
| Pre-Emptive Analgesia in Ano-Rectal Surgery [NCT02402543] | 90 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| Functional Magnetic Resonance Imaging to Predict and Correlate Clinical Outcomes of Ketamine Infusions for Refractory Neuropathic Pain [NCT02373449] | 39 participants (Actual) | Interventional | 2015-02-28 | Completed | |||
| A Randomized, Double Blind, Feasibility Study of Oral Ketamine Versus Placebo for Prevention of Depression in Patients Undergoing Treatment for Pancreatic or Head and Neck Cancers [NCT02442739] | Early Phase 1 | 0 participants (Actual) | Interventional | 2016-08-15 | Withdrawn(stopped due to PI voluntary closure due to low accrual) | ||
| Efficacy of Ketamine in Refractory Convulsive Status Epilepticus in Children: a Multicenter, Randomized, Controlled, Open-label, No-profit, With Sequential Design Study. [NCT02431663] | Phase 3 | 57 participants (Actual) | Interventional | 2015-04-30 | Terminated(stopped due to Futility) | ||
| Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus- a Pilot Study [NCT03115489] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2017-05-04 | Withdrawn(stopped due to Low eligibility of patients, no successful recruitment) | ||
| Treatment of Severe Mucositis Pain With Oral Ketamine Mouthwash [NCT01566448] | Phase 2 | 30 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Ketamine for Relapse Prevention in Recurrent Depressive Disorder: a Randomised, Controlled, Pilot Trial: the KINDRED Trial [NCT02661061] | Phase 1 | 9 participants (Actual) | Interventional | 2015-12-31 | Terminated(stopped due to Inadequate recruitment) | ||
| Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response [NCT05915013] | Phase 1 | 50 participants (Anticipated) | Interventional | 2023-09-07 | Recruiting | ||
| Glutamatergic Mechanisms of Psychosis and Target Engagement (SA1) [NCT04589208] | Phase 1/Phase 2 | 35 participants (Actual) | Interventional | 2021-01-01 | Active, not recruiting | ||
| Comparative Study Between Dexmedetomedine and Ketamine in Erector Spinae Plane Block for Postoperative Analgesia Following Modified Radical Mastectomy. A Prospective Randomized Controlled Study. [NCT05727098] | Phase 2/Phase 3 | 75 participants (Actual) | Interventional | 2023-01-01 | Completed | ||
| A Prospective, Open-Label Pilot Clinical Trial of Oral Ketamine for Acute Pain Management After Amputation Surgery [NCT02341963] | Phase 1 | 5 participants (Actual) | Interventional | 2015-01-31 | Terminated(stopped due to Recruitment issues) | ||
| The Effect of a Mixture of Dexmedetomidine-lidocaine-ketamine in One Syringe Versus Opioids on Recovery Profile and Postoperative Pain After Gynecological Laparoscopic Surgery [NCT04858711] | 60 participants (Anticipated) | Interventional | 2021-04-01 | Recruiting | |||
| Comparison of Effect of Peritonsillar Infiltration of Ketamine and Tramadol on Pediatric Posttonsillectomy Pain: A Double-blinded Randomized Placebo-controlled Clinical Trial [NCT03067103] | Phase 4 | 108 participants (Anticipated) | Interventional | 2017-07-01 | Not yet recruiting | ||
| Effects of Multimodal General Anesthesia for Older Patients Undergoing Lumbar Spine Fusion Surgery: a Randomized Controlled Trial [NCT05247177] | 160 participants (Anticipated) | Interventional | 2022-02-28 | Recruiting | |||
| Understanding the Glutamate System in Adults With Obsessive-Compulsive Disorder With N-methyl-D Aspartate Antagonist Ketamine [NCT01100255] | Phase 2 | 15 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Ketamine Enhancement of rTMS for Refractory Depression [NCT04352621] | Phase 4 | 20 participants (Anticipated) | Interventional | 2020-05-01 | Not yet recruiting | ||
| Phase I/II Trial of Gabapentin Plus Ketamine for Prevention and Treatment of Acute and Chronic Pain in Locally Advanced Head and Neck Cancer Patients Undergoing Primary or Adjuvant Chemoradiation [NCT05156060] | Phase 1/Phase 2 | 44 participants (Anticipated) | Interventional | 2022-01-24 | Recruiting | ||
| Novel Topical Therapies for the Treatment of Genital Pain [NCT02099006] | Phase 2/Phase 3 | 9 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| Intra-operative Ketamine Infusions in Patients With Chronic Lower Back Discomfort Undergoing Laminectomies. [NCT00899600] | 102 participants (Actual) | Interventional | 2007-02-28 | Completed | |||
| Effect of Ketamine Assisted Analgesia on Oxygen Supply and Oxygen Consumption in Patients After Cardiac Surgery [NCT04906915] | 112 participants (Anticipated) | Interventional | 2021-05-08 | Recruiting | |||
| Optimal Dosing of Ketamine for Procedural Sedation and Analgesia in Children [NCT02519595] | Phase 4 | 182 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| Preoperative Low-dose Ketamine Has no Preemptive Analgesic Effect in Opioid-naïve Patients Undergoing Colon Surgery When Nitrous Oxide is Used [NCT02241278] | Phase 4 | 48 participants (Actual) | Interventional | 2001-09-30 | Completed | ||
| Comparison of Ketamine 0.1 mg/kg, 0.2 mg/kg, and 0.3 mg/kg Intravenous Doses for Acute Pain in the Emergency Department: A Prospective, Randomized, Double-blind, Active-controlled, Clinical Trial [NCT03896230] | Phase 4 | 11 participants (Actual) | Interventional | 2019-05-03 | Terminated(stopped due to Due to resource limitations the study was on hold and was then terminated.) | ||
| Pericapsular Nerve Group Block for Positional Pain and Postoperative Analgesia [NCT05079087] | 100 participants (Anticipated) | Interventional | 2021-04-01 | Recruiting | |||
| Ketamine vs. Midazolam: Testing Rapid Relief of Suicide Risk in Depression [NCT01700829] | Phase 4 | 82 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| Double-blind Trial of Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery [NCT03861988] | Phase 4 | 45 participants (Actual) | Interventional | 2019-08-22 | Completed | ||
| Comparative Effectiveness of Multi-modal Pain Management Versus Standard Intra- and Post-operative Analgesia: Randomized Controlled Clinical Trial to Reduce Post-operative Pain and Opioid Use Among Patients Undergoing Lumbar Spine Surgery [NCT03088306] | Early Phase 1 | 49 participants (Actual) | Interventional | 2017-07-01 | Completed | ||
| The Effect of Therapeutic Ketamine Infusions on the Symptoms of Post-Traumatic Stress Disorder in Combat Veterans [NCT03088384] | 30 participants (Actual) | Observational | 2016-11-28 | Completed | |||
| Impact of Dexmedetomidine and Ketamine and Their Combination for the Reduction of Postoperative Morphine Requirements After VATS Surgery [NCT03596424] | 120 participants (Anticipated) | Interventional | 2018-02-01 | Recruiting | |||
| Rapid Reversal of Suicidal Depression: Comparative Effectiveness of ECT vs. KETAMINE Over the Lifespan (REaKT-SD) [NCT06034821] | Phase 4 | 1,500 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | ||
| Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2) [NCT05940324] | Phase 2 | 150 participants (Anticipated) | Interventional | 2023-11-30 | Not yet recruiting | ||
| A 2-part Phase 2 Study to Assess the Efficacy, Safety, and Tolerability of SLS-002 (Intranasal Racemic Ketamine) Administered to Adults With Major Depressive Disorder at Imminent Risk of Suicide [NCT04669665] | Phase 2 | 164 participants (Actual) | Interventional | 2020-12-17 | Completed | ||
| Ketamine Versus Placebo as Adjuvant Treatment for Major Depressive Disorder and Wish to Hasten Death in Advanced Cancer Patients Undergoing Palliative Care [NCT04471818] | Phase 1/Phase 2 | 19 participants (Actual) | Interventional | 2019-09-19 | Completed | ||
| Influence of Ultrasonography Guided Ilioinguinal / Iliohipogastric Block in Intraoperative Anesthesia in Children - Randomized Controlled Study [NCT02990884] | 60 participants (Anticipated) | Interventional | 2016-12-31 | Active, not recruiting | |||
| Is it Possible to Replace Fentanyl by Non Narcotic Medication for Induction and Maintenance of Anesthesia in Minor Procedures? [NCT03806374] | 120 participants (Actual) | Interventional | 2018-01-02 | Completed | |||
| Efficacy and Safety of Multimodal Analgesia Used in Patients With Microvascular Decompression [NCT03152955] | Phase 4 | 90 participants (Anticipated) | Interventional | 2017-05-15 | Active, not recruiting | ||
| Benefit of the Association of Low Doses of Ketamine With Intravenous Morphine in the Treatment of Acute Severe Pain in Emergency Department [NCT03017248] | Phase 1 | 125 participants (Actual) | Interventional | 2016-01-31 | Active, not recruiting | ||
| Effect of Intranasal Midazolam Versus Ketamine Midazolam Combination as a Premedication in Children Undergoing Tonsillectomy and Adenoidectomy on the Occurrence of Postoperative Respiratory Adverse Events: a Double-blind, Randomized Controlled Trial [NCT06122948] | Phase 3 | 200 participants (Anticipated) | Interventional | 2023-09-10 | Recruiting | ||
| Repeated Neurocognitive Measurements in Depressed Patients [NCT05991232] | Phase 1/Phase 2 | 20 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| Ketamine Infusion for Pain Control in Severe Traumatic Injury: A Randomized Controlled Trial [NCT04274361] | 130 participants (Anticipated) | Interventional | 2021-01-20 | Recruiting | |||
| Effect of Adding Dexmedetomidine, Ketamine and Their Combination to Bupivicaine in Thoracic Epidural Analgesia on Post-mastectomy Pain [NCT03063671] | Phase 2/Phase 3 | 20 participants (Anticipated) | Interventional | 2017-01-31 | Completed | ||
| Analgesic Effects of Low-dose S-ketamine in Patients Undergoing Major Spine Fusion Surgery: A Double-blinded, Randomized Controlled Trial [NCT04964219] | Phase 4 | 164 participants (Anticipated) | Interventional | 2022-02-08 | Recruiting | ||
| Quality of Recovery of Opioid Free Anaesthesia Versus Opioids Anaesthesia Within Enhanced Recovery Protocol Following Laparoscopic Sleeve Gastrectomy in Saudi Arabia, Randomized Controlled Trial [NCT04285255] | 103 participants (Actual) | Interventional | 2020-03-01 | Completed | |||
| Per-operative Low-Dose Ketamine For Postoperative Pain Relief In Patients Undergoing Bariatric Surgery: A Randomised Study [NCT03052673] | Phase 4 | 76 participants (Actual) | Interventional | 2017-02-20 | Completed | ||
| Safety and Efficacy Evaluation of S (+) -Ketamine for Postoperative Acute Pain in Children in Perioperative Settings: A Multicenter, Randomized, Open-label, Active Controlled Pragmatic Clinical Trial [NCT04834427] | Phase 4 | 3,000 participants (Anticipated) | Interventional | 2021-05-01 | Not yet recruiting | ||
| Evaluation of the Efficacy of a Single Infusion of Ketamine Combined With Magnesium Sulfate to Treat Refractory Chronic Cluster Headache [NCT04814381] | Phase 4 | 90 participants (Anticipated) | Interventional | 2021-09-15 | Recruiting | ||
| Impact of Ketamine on Epigenetic Age (IKEA) [NCT05294835] | Phase 2 | 20 participants (Anticipated) | Interventional | 2022-04-01 | Recruiting | ||
| Intranasal Ketamine Versus Intranasal Fentanyl on Pain Management in Isolated Traumatic Patients [NCT04414800] | Phase 3 | 125 participants (Actual) | Interventional | 2017-04-01 | Completed | ||
| Pharmacokinetics of Anesthetics and Analgesics in Children and Adolescent [NCT03427736] | 460 participants (Anticipated) | Observational | 2018-12-13 | Recruiting | |||
| Machine-learning Algorithm to Differentiate Intraoperative Ketamine Dosing Based on Electroencephalographic Density Spectrum Array Analysis [NCT05256264] | 90 participants (Anticipated) | Observational | 2022-03-01 | Recruiting | |||
| The Antidepressant Action of Ketamine: Brain Chemistry [NCT01558063] | Phase 2 | 38 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Repeated Ketamine Infusions for Treatment-Resistant Bipolar Disorder: A Randomized, Double-blind, Midazolam-controlled, Phase II Clinical Trial [NCT05004896] | Phase 2 | 100 participants (Anticipated) | Interventional | 2022-04-30 | Recruiting | ||
| Investigation of Antidepressant Efficacy of Oral Ketamine Treatment [NCT02992496] | Phase 2 | 60 participants (Anticipated) | Interventional | 2017-04-24 | Recruiting | ||
| Ketamine Infusion for Obsessive-Compulsive Disorder [NCT01349231] | Phase 2 | 10 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| Opioid-free Anesthesia With a Mixture of Dexmedetomidine-lidocaine-ketamine in Laparoscopic Cholecystectomies [NCT05089526] | 70 participants (Anticipated) | Interventional | 2021-10-11 | Recruiting | |||
| Comparison of Ketamine Versus Co-Administration of Ketamine and Propofol for Procedural Sedation in a Pediatric Emergency Department [NCT01387139] | Phase 3 | 183 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Investigating Rapid Anti-Suicidal Ideation Effects of Intravenous (IV) Ketamine in Hospitalized Patients [NCT01507181] | Phase 4 | 24 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| Ketamine Hydrochloride Versus Magnesium Sulfate as Analgesic Adjuvants in Pediatric Adenotonsillectomy, a Randomized Comparative Study [NCT05565664] | Phase 4 | 38 participants (Anticipated) | Interventional | 2022-10-31 | Not yet recruiting | ||
| Psilocybin and Depression - Assessing the Long-term Effects of a Single Administration of Psilocybin on the Psychiatric Symptoms and Brain Activity of Patients With Severe Depression [NCT03380442] | Phase 2 | 60 participants (Anticipated) | Interventional | 2018-09-30 | Not yet recruiting | ||
| Low Dose Ketamine as an Adjunct to Opiates for Acute Pain in the Emergency Department [NCT02489630] | Phase 4 | 116 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Post-operative Pain Relief in Laparoscopic Cholecystectomy Using a Combination of Intraperitoneal Bupivacaine Morphine, Bupivacaine Fentanyl and Bupivacaine Ketamine: A Comparative Study [NCT03355716] | 120 participants (Anticipated) | Interventional | 2018-01-31 | Not yet recruiting | |||
| Subcutaneous Wound Infiltration of Ketamine is Superior to Bupivacaine in Terms of Pain Perception and Opioid Consumption After Cesarean Section: a Double-blinded Randomized Placebo Controlled Clinical Trial. [NCT02515422] | Phase 1 | 120 participants (Actual) | Interventional | 2014-06-30 | Completed | ||
| A Randomized Controlled Trial to Determine the Efficacy of Ketamine as an Adjunct for Pain Management in Patients With Sickle Cell Crisis [NCT03502421] | Phase 3 | 0 participants (Actual) | Interventional | 2018-09-01 | Withdrawn(stopped due to Never IRB approved, no intention to proceed with the study) | ||
| Mean Effective Dose of Rapidly Administered Ketamine for Brief Pediatric Procedural Sedation [NCT01669642] | 111 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| Oral Ketamine in the Treatment of Depression and Anxiety in Patients With Cancer [NCT01680172] | Phase 2 | 5 participants (Actual) | Interventional | 2012-08-31 | Terminated(stopped due to Slow enrollment) | ||
| Comparative Bioavailability Study of Ketamine and Norketamine After Single Dose Administration of Ketamine 10, 20, 40 and 80 mg Prolonged Release Tablets in Fasting State and 5 mg Ketamine Solution for Infusion in 15 Healthy Subjects in Serum, Urine and F [NCT02494830] | Phase 1 | 15 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| Understanding the Safety of Home Ketamine Treatment Plans for Chronic Conditions [NCT06038409] | 500 participants (Anticipated) | Observational | 2023-01-01 | Recruiting | |||
| Repeated Neurocognitive Measurements in Depressed Patients [NCT04916548] | Phase 1/Phase 2 | 15 participants (Actual) | Interventional | 2021-09-16 | Completed | ||
| The Effect and Contribution of a Perioperative Ketamine Infusion in an Established Enhanced Recovery Pathway [NCT04625283] | Phase 4 | 1,544 participants (Anticipated) | Interventional | 2021-04-12 | Enrolling by invitation | ||
| Intravenous Infusions of S-KETAMINE in Fibromyalgia Syndromes: an Exploratory Study. [NCT04436250] | 210 participants (Anticipated) | Interventional | 2020-10-10 | Recruiting | |||
| Comparison of Effects of Intravenous Midazolam and Ketamine on Emergence Agitation : a Randomized Controlled Trial [NCT02256358] | 68 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| Intramuscular Ketamine Effect on Postnasal Surgery Agitation: a Double Blinded Randomized Controlled Trial. [NCT05313659] | Phase 2 | 193 participants (Actual) | Interventional | 2022-05-11 | Completed | ||
| Combined Ketamine/Propofol for Emergency Department Procedural Sedation [NCT01126957] | 107 participants (Actual) | Interventional | 2007-05-31 | Terminated(stopped due to Investigator left institution.) | |||
| The Check Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine. A Multi-Center, Randomized Double-Blind, Clinical Control Trial. [NCT02657031] | Phase 4 | 54 participants (Actual) | Interventional | 2016-03-17 | Completed | ||
| Testing a Synergistic, Neuroplasticity-Based Intervention for Depressive Neurocognition [NCT03237286] | Phase 1/Phase 2 | 154 participants (Actual) | Interventional | 2017-12-01 | Completed | ||
| Ketamine for The Rapid Treatment of Major Depression and Alcohol Use Disorder [NCT02461927] | Phase 1/Phase 2 | 65 participants (Actual) | Interventional | 2015-01-01 | Completed | ||
| A Multi-center Randomized Controlled Trial of Efficacy and Safety of Intravenous Ketamine for Chronic Daily Headaches: The KetHead Study [NCT05306899] | Phase 3 | 56 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting | ||
| A Randomized Pilot Study Examining DCEEG Characteristics in Ketamine Versus Methohexital Induction in Depressed Patients Receiving Electroconvulsive Therapy [NCT04022226] | Early Phase 1 | 11 participants (Actual) | Interventional | 2019-10-01 | Completed | ||
| Multimodal Analgesia Versus Traditional Opiate Based Analgesia and Cardiac Surgery Outcome [NCT03521167] | 225 participants (Anticipated) | Interventional | 2018-05-01 | Not yet recruiting | |||
| Effect of Ketamine Versus Sufentanil on Cerebral Glutamate After Traumatic Brain Injury : a Randomized, Double-blinded, Microdialysis Study [NCT02232347] | Phase 2 | 20 participants (Anticipated) | Interventional | 2014-10-31 | Not yet recruiting | ||
| Subcutaneous Ketamine for Postoperative Pain Relief in Rwanda: a Randomized Control Trial [NCT02514122] | Phase 2/Phase 3 | 61 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| IM Ketamine vs Midazolam for Suicidal ER Patients [NCT04640636] | Phase 4 | 90 participants (Anticipated) | Interventional | 2021-01-02 | Active, not recruiting | ||
| "A Randomized-Controlled Trial to Compare the Effect of Propofol vs. Ketofol on Hemodynamic Stability During Induction of General Anesthesia" [NCT02282891] | Phase 2 | 0 participants (Actual) | Interventional | 2015-01-31 | Withdrawn(stopped due to No subjects were ever recruited and enrolled.) | ||
| Evaluating the Effect of Subanaesthetic Dose of Esketamine on Prevention of Postoperative Depression in Patients Undergoing Cardiac Surgery：a Randomized, Double-blind, Placebo-controlled Pilot and Feasibility Trial [NCT05155969] | 80 participants (Anticipated) | Interventional | 2021-12-01 | Recruiting | |||
| Ketamine as an Adjunctive Therapy for Major Depression - A Randomised Controlled Trial: [KARMA-Dep (2)] [NCT04939649] | Phase 3 | 104 participants (Anticipated) | Interventional | 2021-09-13 | Recruiting | ||
| Intranasal Ketamine Use in the Management of Upper Limb's Fracture Reduction in Pediatric Emergencies [NCT03525821] | Phase 3 | 9 participants (Actual) | Interventional | 2018-07-05 | Completed | ||
| Comparison of Analgesic Effectiveness of Intravenous Ketamine and Fentanyl for Spinal Anesthesia is Sitting Position in Patients With Proximal Femur Fracture [NCT04418674] | 52 participants (Anticipated) | Interventional | 2020-06-25 | Recruiting | |||
| The Immunomodulatory Effects of Ketamine and Lidocaine in Abdominal Surgery: Double-Blind, Placebo-Controlled Clinical Study [NCT03821545] | 82 participants (Actual) | Interventional | 2019-01-28 | Completed | |||
| Single-dose Ketamine to Reduce Pain Severity, Depressive Symptoms and the Need for Opiates Both During and After Emergency Department Care [NCT03436121] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2019-12-31 | Withdrawn(stopped due to Ketamine shortage during the funding period of the trial) | ||
| The Effect Of Adding Ketamine to Propofol For Drug-induced Sleep Endoscopy in Adult Patients With Obstructive Sleep Apnea A Randomized Controlled Study [NCT04452383] | Phase 4 | 30 participants (Anticipated) | Interventional | 2020-07-23 | Recruiting | ||
| Low Dose Ketamine for Acute Pain Crisis in Patients With Sickle Cell Disease [NCT04330183] | Phase 4 | 20 participants (Actual) | Interventional | 2020-07-01 | Completed | ||
| Ketamine Reduces Tourniquet Pain In Patients Undergoing Lower Limb Surgery Under Spinal Anaesthesia [NCT03357055] | Phase 4 | 60 participants (Anticipated) | Interventional | 2017-12-13 | Not yet recruiting | ||
| A Phase II, Randomised, Double-blind, Placebo- Controlled, Multi-site, Parallel Group Clinical Trial to Examine Ketamine as a Pharmacological Treatment for Alcohol Dependence in an Alcohol Dependent Population [NCT02649231] | Phase 2 | 96 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| Esketamine Combined With Pregabalin on Chronic Postsurgical Pain in Patients Undergoing Primary Spinal Tumor Surgery. [NCT06117917] | Phase 2/Phase 3 | 150 participants (Anticipated) | Interventional | 2023-11-10 | Not yet recruiting | ||
| Comparison of Pain and Comfort in Patients Following Cardiac Surgery: Opioid- Morphine Managed Versus Multimodal Pain-management [NCT04987372] | Phase 4 | 100 participants (Actual) | Interventional | 2019-01-21 | Completed | ||
| Effect of Intravenous S-ketamine on Opioid Consumption and Postoperative Pain in Patients Undergoing Breast Cancer Surgery：a Multicenter, Randomised, Control Trial [NCT05060068] | 352 participants (Anticipated) | Interventional | 2021-10-07 | Recruiting | |||
| Intravenous Ketamine for Pain Control During First Trimester Surgical Abortion [NCT03751423] | Phase 3 | 123 participants (Anticipated) | Interventional | 2019-06-10 | Suspended(stopped due to Study on-hold due to COVID-19 pandemic restrictions. Will resume when possible.) | ||
| Anesthetic Techniques and the Effect on Cardiac Electrophysiology Procedures [NCT02664922] | Phase 4 | 35 participants (Actual) | Interventional | 2012-05-31 | Terminated(stopped due to Poor study design and too many study groups.) | ||
| NMDA Antagonists in Bipolar Depression [NCT01833897] | Phase 4 | 8 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| A Randomized, Double-Blinded Controlled Trial of an N-Methyl D-Aspartate Antagonist as a Rapidly-Acting Antidepressant in Depressed Emergency Department Patients [NCT02106325] | Phase 2 | 21 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| Ketamine Patient-Controlled Analgesia for Acute Pain in Native Airway Multiple and Orthopedic Trauma Patients: A Randomized, Active Comparator, Blinded Trial [NCT02062879] | Phase 3 | 20 participants (Actual) | Interventional | 2014-04-30 | Terminated(stopped due to Withdrawals from study due to anticipated effects from study drugs) | ||
| Extending Ketamine's Effects in Obsessive-Compulsive Disorder (OCD) With Exposure and Response Prevention (EX/RP) [NCT02062658] | Phase 2 | 10 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| Observational Study of the Efficacy of Ketamine for Rescue Analgesia in the Post Anesthesia Recovery Room [NCT04701008] | 143 participants (Actual) | Observational | 2020-09-01 | Completed | |||
| Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive Symptoms [NCT02422303] | 12 participants (Actual) | Interventional | 2015-12-31 | Terminated | |||
| Spreading Depolarization and Ketamine Suppression [NCT02501941] | Phase 1 | 10 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Assessing a Combined Ketamine and Online Cognitive Behavioural Therapy Intervention for Treatment Resistant Post-Traumatic Stress Disorder [NCT04771767] | Phase 2 | 16 participants (Anticipated) | Interventional | 2021-08-01 | Recruiting | ||
| Preoperative Ketamine as a Strategy to Decrease Perioperative Depression During the Perioperative Period: a Randomized Active Controlled Pilot Study [NCT04220125] | Phase 4 | 0 participants (Actual) | Interventional | 2022-09-01 | Withdrawn(stopped due to No enrollment) | ||
| Rapid Agitation Control With Ketamine in the Emergency Department (RACKED): a Randomized Controlled Trial [NCT03375671] | Phase 2 | 81 participants (Actual) | Interventional | 2018-05-29 | Completed | ||
| Intrathecally Administered Ketamine, Dexmedetomidine, and Their Combination With Bupivacaine for Postoperative Analgesia in Major Abdominal Cancer Surgery [NCT02455609] | Phase 2/Phase 3 | 90 participants (Anticipated) | Interventional | 2015-03-31 | Active, not recruiting | ||
| Ambulatory Infusion of Lidocaine and Ketamine for Management of Chronic Pain: An Observational Prospective Study [NCT03249025] | 72 participants (Anticipated) | Interventional | 2017-09-01 | Not yet recruiting | |||
| Intranasal Ketamine for Treatment of Acute Pain in the Emergency Department : A Randomized Controlled Trial [NCT03233035] | Phase 2 | 1,102 participants (Actual) | Interventional | 2018-01-01 | Completed | ||
| Propofol-Ketamine vs. Propofol-Fentanyl for Sedation During Pediatric Diagnostic Gastrointestinal Endoscopy [NCT03235609] | 60 participants (Anticipated) | Interventional | 2017-08-16 | Not yet recruiting | |||
| Effect of Intraoperative IV Ketamine on Postoperative Morphine Consumption During Intestinal Surgery and Its Effect on Salivary Cortisol and Alpha Amylase Levels [NCT03344393] | 60 participants (Anticipated) | Interventional | 2017-12-01 | Not yet recruiting | |||
| Non Randomized Cohort Study to Evaluate Pre-operative Ketamine Infusion for the Decrease Overall Pain Levels Following Revision Cervical or Lumbar Fusion Surgery Through the Post-operative Phase, Decreasing Reliance on Opioids for Daily Pain Control, Opio [NCT06066879] | Phase 4 | 40 participants (Anticipated) | Interventional | 2023-09-18 | Recruiting | ||
| Does Modulation of Glutamate Transmission in the Brain Using a Sub-anaesthetic Dose of Ketamine Affect Autobiographical Memory, Emotional Processing and Decision-making in Treatment-resistant Depression? [NCT05809609] | 60 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | |||
| A Pilot Phase 1, Randomized, Single-Dose, 6-Sequences, 3-Period, Crossover Bioavailability Study of MELT-100 (Midazolam and Ketamine Sublingual Tablet) and Intravenous Midazolam or Ketamine in Healthy Volunteers [NCT04485702] | Phase 1 | 17 participants (Actual) | Interventional | 2020-07-20 | Completed | ||
| Comparison of Opioid Based and Opioid Free Anaesthesia in Transsphenoidal Surgery for Haemodynamic Stability and Recovery Characteristics [NCT03120234] | 60 participants (Actual) | Interventional | 2017-01-31 | Completed | |||
| Ketamine Infusion for Acute Sickle Cell crisiS in the Emergency Department [NCT02417298] | 12 participants (Actual) | Interventional | 2015-11-30 | Terminated(stopped due to Feasibility) | |||
| Intranasal Ketamine Versus Intravenous Ketamine for Procedural Conscious Sedation in Children: a Multi-centre Randomized Controlled Non-inferiority Trial [NCT02402868] | Phase 3 | 17 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| PET Imaging of mGluR5 With Drug Challenge [NCT01691092] | 79 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
| The Use of Ketamine Versus Methohexital for Electroconvulsive Therapy: A Cross-Over Comparative Study on Patient Recovery and Re-Orientation Time [NCT01567852] | 20 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Patient-controlled Analgesia After Scoliosis Correction Surgery: a Randomized, Double-blind, Placebo-controlled Trial [NCT04791059] | Phase 4 | 200 participants (Actual) | Interventional | 2021-04-09 | Completed | ||
| Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD) [NCT01920555] | Phase 2 | 99 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||