A 17-beta-hydroxysteroid dehydrogenase type 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P37059]
17-beta-HSD 2; This protein enables 3 target(s): This protein is located in 1 target(s): This protein is active in 1 target(s): This protein is involved in 6 target(s):
20 alpha-hydroxysteroid dehydrogenase;
20-alpha-HSD;
E2DH;
Estradiol 17-beta-dehydrogenase 2;
1.1.1.62;
Microsomal 17-beta-hydroxysteroid dehydrogenase;
Short chain dehydrogenase/reductase family 9C member 2;Research
Bioassay Publications (9)
Timeframe Studies on this Protein(%) All Drugs % pre-1990 0 (0.00) 18.7374 1990's 0 (0.00) 18.2507 2000's 5 (55.56) 29.6817 2010's 4 (44.44) 24.3611 2020's 0 (0.00) 2.80 Compounds (19)
Drugs with Inhibition Measurements
Drug Taxonomy Measurement Average (mM) Bioassay(s) Publication(s) masoprocol Homo sapiens (human) IC50 0.3800 1 1 acetylglycyrrhetinic acid Homo sapiens (human) IC50 3.7800 1 1 naringenin Homo sapiens (human) IC50 14.4000 2 2 isoliquiritigenin Homo sapiens (human) IC50 0.3600 1 1 curcumin Homo sapiens (human) IC50 1.7300 1 1 3-(1-adamantyl)-6,7,8,9-tetrahydro-5h-(1,2,4)triazolo(4,3-a)azepine Homo sapiens (human) IC50 3.3000 1 1 quercetin Homo sapiens (human) IC50 1.5400 2 2 biochanin a Homo sapiens (human) IC50 9.9000 2 2 apigenin Homo sapiens (human) IC50 20.0000 2 2 kaempferol Homo sapiens (human) IC50 0.3600 2 2 genistein Homo sapiens (human) IC50 16.5000 2 2 butein Homo sapiens (human) IC50 7.3000 1 1 rosmarinic acid Homo sapiens (human) IC50 3.7200 1 1 7-hydroxyflavone Homo sapiens (human) IC50 20.0000 2 2 2'-hydroxygenistein Homo sapiens (human) IC50 2.0300 1 1 jaceosidin Homo sapiens (human) IC50 9.3000 1 1 bvt2733 Homo sapiens (human) IC50 0.0960 1 1 6-(3-hydroxyphenyl)-2-naphthol Homo sapiens (human) IC50 5.6410 4 4 Drugs with Activation Measurements
Drug Taxonomy Measurement Average (mM) Bioassay(s) Publication(s) gsk 1016790a Homo sapiens (human) EC50 0.0490 1 1 Enables
Target Category Definition estradiol 17-beta-dehydrogenase [NAD(P)] activity molecular function Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor. [EC:1.1.1.62] 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity molecular function Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone. [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN] testosterone dehydrogenase (NAD+) activity molecular function Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH. [EC:1.1.1.239] Located In
Target Category Definition endoplasmic reticulum membrane cellular component The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] Active In
Target Category Definition intracellular membrane-bounded organelle cellular component Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] Involved In
Target Category Definition in utero embryonic development biological process The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. [GOC:go_curators, GOC:mtg_sensu] placenta development biological process The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. [GOC:add, ISBN:068340007X] estrogen biosynthetic process biological process The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732] androgen metabolic process biological process The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. [ISBN:0198506732] response to retinoic acid biological process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. [GOC:sl] steroid metabolic process biological process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]