17-beta-hydroxysteroid dehydrogenase type 2

A 17-beta-hydroxysteroid dehydrogenase type 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P37059]

Synonyms

17-beta-HSD 2;
20 alpha-hydroxysteroid dehydrogenase;
20-alpha-HSD;
E2DH;
Estradiol 17-beta-dehydrogenase 2;
1.1.1.62;
Microsomal 17-beta-hydroxysteroid dehydrogenase;
Short chain dehydrogenase/reductase family 9C member 2;

Research

Bioassay Publications (9)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (55.56)	29.6817
2010's	4 (44.44)	24.3611
2020's	0 (0.00)	2.80

Compounds (19)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
masoprocol	Homo sapiens (human)	IC50	0.3800	1	1
acetylglycyrrhetinic acid	Homo sapiens (human)	IC50	3.7800	1	1
naringenin	Homo sapiens (human)	IC50	14.4000	2	2
isoliquiritigenin	Homo sapiens (human)	IC50	0.3600	1	1
curcumin	Homo sapiens (human)	IC50	1.7300	1	1
3-(1-adamantyl)-6,7,8,9-tetrahydro-5h-(1,2,4)triazolo(4,3-a)azepine	Homo sapiens (human)	IC50	3.3000	1	1
quercetin	Homo sapiens (human)	IC50	1.5400	2	2
biochanin a	Homo sapiens (human)	IC50	9.9000	2	2
apigenin	Homo sapiens (human)	IC50	20.0000	2	2
kaempferol	Homo sapiens (human)	IC50	0.3600	2	2
genistein	Homo sapiens (human)	IC50	16.5000	2	2
butein	Homo sapiens (human)	IC50	7.3000	1	1
rosmarinic acid	Homo sapiens (human)	IC50	3.7200	1	1
7-hydroxyflavone	Homo sapiens (human)	IC50	20.0000	2	2
2'-hydroxygenistein	Homo sapiens (human)	IC50	2.0300	1	1
jaceosidin	Homo sapiens (human)	IC50	9.3000	1	1
bvt2733	Homo sapiens (human)	IC50	0.0960	1	1
6-(3-hydroxyphenyl)-2-naphthol	Homo sapiens (human)	IC50	5.6410	4	4

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
gsk 1016790a	Homo sapiens (human)	EC50	0.0490	1	1

Enables

This protein enables 3 target(s):

Target	Category	Definition
estradiol 17-beta-dehydrogenase [NAD(P)] activity	molecular function	Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor. [EC:1.1.1.62]
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	molecular function	Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone. [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN]
testosterone dehydrogenase (NAD+) activity	molecular function	Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH. [EC:1.1.1.239]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]

Involved In

This protein is involved in 6 target(s):

Target	Category	Definition
in utero embryonic development	biological process	The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. [GOC:go_curators, GOC:mtg_sensu]
placenta development	biological process	The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. [GOC:add, ISBN:068340007X]
estrogen biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732]
androgen metabolic process	biological process	The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. [ISBN:0198506732]
response to retinoic acid	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. [GOC:sl]
steroid metabolic process	biological process	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]

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