Proteins > Corticosteroid 11-beta-dehydrogenase isozyme 1
Page last updated: 2024-08-07 16:47:09
Corticosteroid 11-beta-dehydrogenase isozyme 1
An 11-beta-hydroxysteroid dehydrogenase 1 that is encoded in the genome of mouse. [OMA:P50172, PRO:DNx]
Synonyms
EC 1.1.1.146;
11-beta-hydroxysteroid dehydrogenase 1;
11-DH;
11-beta-HSD1;
11beta-HSD1A
Research
Bioassay Publications (22)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (36.36) | 29.6817 |
| 2010's | 12 (54.55) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
Compounds (14)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| glycyrrhizic acid | Mus musculus (house mouse) | EC50 | 0.0080 | 1 | 1 |
Synthesis of selective 11β-HSD1 inhibitors based on dammarane scaffold.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Limonoids and Triterpenoids as 11β-HSD1 Inhibitors from Walsura robusta.Journal of natural products, , Apr-22, Volume: 79, Issue:4, 2016
Hupehenols A-E, selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors from Viburnum hupehense.Journal of natural products, , Feb-27, Volume: 78, Issue:2, 2015
Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: potential impact in diabetes.European journal of medicinal chemistry, , Volume: 65, 2013
Structure-based virtual screening for identification of novel 11beta-HSD1 inhibitors.European journal of medicinal chemistry, , Volume: 44, Issue:3, 2009
Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 18, Issue:4, 2008
Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11β-hydroxysteroid dehydrogenases.Journal of natural products, , Apr-27, Volume: 75, Issue:4, 2012
Synthesis and evaluation of piperidine urea derivatives as efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 22, Issue:8, 2012
Cyclopeptide Alkaloids from Ziziphus apetala.Journal of natural products, , Dec-27, Volume: 74, Issue:12, 2011
4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Optimization of cyclic sulfamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitors for the potential treatment of ischemic brain injury.Bioorganic & medicinal chemistry letters, , 01-15, Volume: 30, Issue:2, 2020
Synthesis and 11β hydroxysteroid dehydrogenase 1 inhibition of thiazolidine derivatives with an adamantyl group.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1.Journal of medicinal chemistry, , Aug-29, Volume: 45, Issue:18, 2002
Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11β-HSD1 using a scaffold-hopping approach.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 69, 2022
Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: potential impact in diabetes.European journal of medicinal chemistry, , Volume: 65, 2013
Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 20, Issue:5, 2010
Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 18, Issue:11, 2008
4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 18, Issue:11, 2008