A tryptophan 5-hydroxylase 1 that is encoded in the genome of rat. [OMA:P09810, PRO:DNx]
EC 1.14.16.4;
Tryptophan 5-monooxygenase 1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| citalopram | Rattus norvegicus (Norway rat) | Ki | 16.5400 | 1 | 1 |
| desipramine | Rattus norvegicus (Norway rat) | Ki | 0.0005 | 1 | 1 |
| mazindol | Rattus norvegicus (Norway rat) | Ki | 0.0450 | 1 | 1 |
| nisoxetine | Rattus norvegicus (Norway rat) | Ki | 0.0300 | 1 | 1 |
| thioridazine | Rattus norvegicus (Norway rat) | IC50 | 0.0600 | 1 | 1 |
| apomorphine | Rattus norvegicus (Norway rat) | IC50 | 0.2200 | 1 | 1 |
| 2-amino-5,6-dihydroxytetralin | Rattus norvegicus (Norway rat) | IC50 | 0.7000 | 1 | 1 |
| alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol | Rattus norvegicus (Norway rat) | IC50 | 6.4300 | 1 | 1 |
| tamsulosin | Rattus norvegicus (Norway rat) | Ki | 0.0130 | 1 | 1 |
| cocaine | Rattus norvegicus (Norway rat) | Ki | 0.4900 | 1 | 1 |
| 2-[(2-ethoxyphenoxy)-phenylmethyl]morpholine | Rattus norvegicus (Norway rat) | Ki | 0.0600 | 1 | 1 |
| fluvoxamine | Rattus norvegicus (Norway rat) | Ki | 0.0015 | 1 | 1 |
| dinapsoline | Rattus norvegicus (Norway rat) | IC50 | 0.0380 | 1 | 1 |
| [2-[[2-[(dimethylamino)methyl]phenyl]thio]-5-iodophenyl]methanol | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| lp533401 | Rattus norvegicus (Norway rat) | IC50 | 0.4000 | 1 | 1 |