isoniazid has been researched along with Necrosis in 37 studies
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pharmacokinetic parameters of isoniazid, hydrazine (a metabolite of isoniazid), rifampicin and pyrazinamide in a 74-year-old man with pulmonary tuberculosis who died of submassive hepatic necrosis eight days after starting antituberculosis therapy were compared with those of other elderly patients who did not develop hepatotoxicity." | 7.68 | Hydrazine--a possible cause of isoniazid--induced hepatic necrosis. ( Chan, CH; Chan, KK; Walubo, A; Woo, J, 1992) |
| "Pharmacokinetic parameters of isoniazid, hydrazine (a metabolite of isoniazid), rifampicin and pyrazinamide in a 74-year-old man with pulmonary tuberculosis who died of submassive hepatic necrosis eight days after starting antituberculosis therapy were compared with those of other elderly patients who did not develop hepatotoxicity." | 3.68 | Hydrazine--a possible cause of isoniazid--induced hepatic necrosis. ( Chan, CH; Chan, KK; Walubo, A; Woo, J, 1992) |
| " A potentially toxic INH dose (120 mg/kg) was injected by i." | 1.42 | Circadian variation in murine hepatotoxicity to the antituberculosis agent «Isoniazide». ( Aouam, K; Ben-Attia, M; Boughattas, F; Boughattas, NA; Chennoufi, M; Haouas, Z; Maaroufi, K; Miled, A; Reinberg, A; Souayed, N, 2015) |
| "So we diagnosed her as having intracranial tuberculoma." | 1.30 | [A case of intracranial tuberculoma followed by MRI]. ( Hashimoto, Y; Honda, I; Teramoto, H; Uchino, M; Yonemura, K, 1998) |
| "Eleven cases of papulonecrotic tuberculid (PNT) were seen at the Institute of Dermatology, Bangkok, over a 2-year period (1985 to 1986)." | 1.28 | Papulonecrotic tuberculid. Necessity of long-term triple regimens. ( Kullavanijaya, P; Sirimachan, S; Suwantaroj, S, 1991) |
| "We report three cases of patients with erythema induratum of Bazin who showed extreme tuberculin hypersensitivity reactions and a good therapeutic response to isoniazid." | 1.28 | Erythema induratum of Bazin as a type of tuberculid. ( Aiba, S; Kuramoto, Y; Tagami, H, 1990) |
| "Isoniazid and rifampin were started, but both were stopped by the patient after less than 6 months of therapy." | 1.27 | Tuberculous aortitis with associated necrosis and perforation: treatment and options. ( Burns, DK; Cargile, JS; Fisher, DF; Fry, WJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (59.46) | 18.7374 |
| 1990's | 5 (13.51) | 18.2507 |
| 2000's | 4 (10.81) | 29.6817 |
| 2010's | 4 (10.81) | 24.3611 |
| 2020's | 2 (5.41) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, G | 1 |
| Chen, L | 1 |
| Wen, Y | 1 |
| Rao, Z | 1 |
| Wei, Y | 1 |
| Wu, X | 1 |
| Gengenbacher, M | 1 |
| Duque-Correa, MA | 1 |
| Kaiser, P | 1 |
| Schuerer, S | 1 |
| Lazar, D | 1 |
| Zedler, U | 1 |
| Reece, ST | 1 |
| Nayyar, A | 1 |
| Cole, ST | 1 |
| Makarov, V | 1 |
| Barry Iii, CE | 1 |
| Dartois, V | 1 |
| Kaufmann, SHE | 1 |
| Vazquez-Lopez, F | 1 |
| Fueyo-Casado, A | 1 |
| Gonzalez-Lara, L | 1 |
| Souayed, N | 1 |
| Chennoufi, M | 1 |
| Boughattas, F | 1 |
| Haouas, Z | 1 |
| Maaroufi, K | 1 |
| Miled, A | 1 |
| Ben-Attia, M | 1 |
| Aouam, K | 1 |
| Reinberg, A | 1 |
| Boughattas, NA | 1 |
| Khan, SR | 1 |
| Aljuhani, N | 1 |
| Morgan, AG | 1 |
| Baghdasarian, A | 1 |
| Fahlman, RP | 1 |
| Siraki, AG | 1 |
| Frank, I | 1 |
| Lahav, D | 1 |
| Aroch, I | 1 |
| Botha, T | 1 |
| Ryffel, B | 1 |
| Panchabhai, TS | 1 |
| Ambarkhane, SV | 1 |
| Joshi, AS | 1 |
| Samant, BD | 1 |
| Rege, NN | 1 |
| Bondarev, IM | 1 |
| Ivanov, VL | 1 |
| Novoselova, VP | 1 |
| Kovaleva, LA | 1 |
| Shtegel'man, LA | 1 |
| Lenders, JW | 1 |
| Bartelink, AK | 1 |
| van Herwaarden, CL | 1 |
| van Haelst, UJ | 1 |
| van Tongeren, JH | 1 |
| van der Grient, AJ | 1 |
| Kelderman, CS | 1 |
| Maddrey, WC | 2 |
| Bahri, AK | 1 |
| Chiang, CS | 1 |
| Timbrell, JA | 1 |
| Sarich, TC | 1 |
| Adams, SP | 1 |
| Zhou, T | 1 |
| Wright, JM | 1 |
| Yonemura, K | 1 |
| Teramoto, H | 1 |
| Honda, I | 1 |
| Hashimoto, Y | 1 |
| Uchino, M | 1 |
| Bruña-Romero, O | 1 |
| González-Aseguinolaza, G | 1 |
| Hafalla, JC | 1 |
| Tsuji, M | 1 |
| Nussenzweig, RS | 1 |
| Mitchell, JR | 2 |
| Potter, WZ | 1 |
| Boitnott, JK | 1 |
| Berthelot, P | 1 |
| Nelson, SD | 1 |
| Thorgeirsson, SS | 1 |
| McMurtry, RJ | 1 |
| Dybing, E | 2 |
| Bloomfield, SE | 1 |
| Mondino, B | 1 |
| Gray, GF | 1 |
| Förström, L | 1 |
| Winkelmann, RK | 1 |
| Zimmerman, HJ | 1 |
| Woo, J | 1 |
| Chan, CH | 1 |
| Walubo, A | 1 |
| Chan, KK | 1 |
| Kullavanijaya, P | 1 |
| Sirimachan, S | 1 |
| Suwantaroj, S | 1 |
| Kuramoto, Y | 1 |
| Aiba, S | 1 |
| Tagami, H | 1 |
| Kasantikul, V | 1 |
| Cargile, JS | 1 |
| Fisher, DF | 1 |
| Burns, DK | 1 |
| Fry, WJ | 1 |
| LaMont, JT | 1 |
| Bailey, WC | 1 |
| Thompson, DH | 1 |
| Carson, B | 1 |
| Greenberg, HB | 1 |
| Austerhoff, A | 1 |
| Kindler, U | 1 |
| Knop, P | 1 |
| Knieriem, HJ | 1 |
| Kent, DC | 1 |
| Baghdassarian, SA | 1 |
| Zakharia, H | 1 |
| Asdourian, KK | 1 |
| Hollinrake, K | 1 |
| Godwin, MC | 1 |
| Moros, M | 1 |
| Lewinska, A | 1 |
| Merola, F | 1 |
| Ferraro, P | 1 |
| Wnuk, M | 1 |
| Tino, A | 1 |
| Tortiglione, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1b/2a Safety and Immunogenicity of the DNMT Inhibitor Azacitidine During Anti-Tuberculosis Therapy[NCT03941496] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2022-10-31 | Withdrawn (stopped due to The study was halted prematurely due to Bristol-Myers Squibb's (BMS) decision to withdraw support for this study.) | ||
| A Phase Ib Safety and Immunogenicity Clinical Trial of Heterologous Prime-boost Immunisation With ChAd3-EBO Z and MVA-EBO Z in Healthy Senegalese Adult Volunteers Aged 18-50 Years.[NCT02485912] | Phase 1 | 40 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The specific endpoints for safety and reactogenicity will be actively and passively collected data on adverse events.~The following parameters will be assessed for both groups:~Occurrence of solicited local reactogenicity signs and symptoms for 7 days following the vaccination~Occurrence of solicited systemic reactogenicity signs and symptoms for 7 days following the vaccination~Occurrence of unsolicited adverse events for 28 days following the vaccination~Change from baseline for safety laboratory measures~Occurrence of serious adverse events during the whole study duration" (NCT02485912)
Timeframe: 26 weeks
| Intervention | participants (Number) |
|---|---|
| Group 1 | 20 |
| Group 2 | 20 |
"Ebolavirus specific immunogenicity will be assessed by a variety of immunological assays. The primary immunogenicity outcome measures are ELISA and neutralization antigen-specific assays for antibody responses and intracellular cytokine staining (ICS) assay for T cell responses.~Exploratory outcome measures will include ex-vivo ELISPOT, plasma blast assays and flow cytometry performed with research samples collected at different study timepoints as well as other immunogenicity assays throughout the study. An evaluation of genetic factors associated with immune responses may be performed as exploratory evaluation. Vaccine-induced mRNA expression profiles during 1 week after vaccination may also be performed as an exploratory evaluation." (NCT02485912)
Timeframe: 26 weeks
| Intervention | participants (Number) |
|---|---|
| Group 1 | 20 |
| Group 2 | 20 |
5 reviews available for isoniazid and Necrosis
| Article | Year |
|---|---|
Drug-related acute and chronic hepatitis.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Hypersen | 1980 |
Drug metabolism in the production of liver injury.
Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur | 1975 |
Drug-induced chronic hepatitis and cirrhosis.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adve | 1979 |
Metabolic activation: biochemical basis for many drug-induced liver injuries.
Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hyp | 1976 |
Postoperative juandice.
Topics: Aminosalicylic Acids; Anemia, Hemolytic; Bile Ducts; Bilirubin; Chemical and Drug Induced Liver Inju | 1974 |
32 other studies available for isoniazid and Necrosis
| Article | Year |
|---|---|
Pyridoxal isonicotinoyl hydrazone inhibition of FXR is involved in the pathogenesis of isoniazid-induced liver injury.
Topics: Animals; Apoptosis; Behavior, Animal; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; | 2020 |
NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Fibrosis; Foam Cells; Humans; Hypoxia; Isoni | 2017 |
Lupus Vulgaris Erythematoides: report of a patient initially misdiagnosed as dermatitis.
Topics: Adrenal Cortex Hormones; Aged, 80 and over; Anti-Bacterial Agents; Antitubercular Agents; Biopsy; Ca | 2013 |
Circadian variation in murine hepatotoxicity to the antituberculosis agent «Isoniazide».
Topics: Animals; Antitubercular Agents; Biomarkers; Chemical and Drug Induced Liver Injury; Circadian Rhythm | 2015 |
Cytoprotective effect of isoniazid against H2O2 derived injury in HL-60 cells.
Topics: Cell Death; Cytoprotection; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Hydrogen Peroxide | 2016 |
Myocardial necrosis and severe metabolic acidosis associated with isoniazid poisoning in a dog.
Topics: Acidosis; Animals; Antitubercular Agents; Dog Diseases; Dogs; Female; Isoniazid; Liver; Myocardium; | 2002 |
Reactivation of latent tuberculosis infection in TNF-deficient mice.
Topics: Animals; Cell Migration Inhibition; Chemokines; Down-Regulation; Granuloma; Isoniazid; Lymphocyte Ac | 2003 |
Protective effect of Tinospora cordifolia, Phyllanthus emblica and their combination against antitubercular drugs induced hepatic damage: an experimental study.
Topics: Animals; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; I | 2008 |
[Effectiveness of the rapid intravenous administration of rifampicin and isoniazid and of the intramuscular administration of streptomycin in disseminated destructive pulmonary tuberculosis in dogs].
Topics: Animals; Dogs; Drug Evaluation, Preclinical; Drug Therapy, Combination; Guinea Pigs; Injections, Int | 1984 |
[Fatal liver cell necrosis following short-term administration of isoniazid and rifampicin to a patient already under treatment with antiepileptics].
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Interactions; Hepatic Encephalopathy; | 1983 |
[Fatal liver cell necrosis after short-term administration of isoniazid and rifampicin to a patient already under treatment with anti-epileptic agents].
Topics: Adult; Carbamazepine; Female; Hepatic Encephalopathy; Humans; Isoniazid; Liver; Necrosis; Rifampin | 1983 |
Factors affecting acetylhydrazine hepatotoxicity.
Topics: Animals; Cytochrome P-450 Enzyme System; Hydrazines; Isoniazid; Liver; Male; Necrosis; Phenobarbital | 1981 |
Isoniazid-induced hepatic necrosis and steatosis in rabbits: absence of effect of gender.
Topics: Animals; Antitubercular Agents; Argininosuccinate Lyase; Fatty Liver; Female; Hypertriglyceridemia; | 1997 |
[A case of intracranial tuberculoma followed by MRI].
Topics: Antitubercular Agents; Brain; Female; Follow-Up Studies; Humans; Isoniazid; Magnetic Resonance Imagi | 1998 |
Complete, long-lasting protection against malaria of mice primed and boosted with two distinct viral vectors expressing the same plasmodial antigen.
Topics: Animals; Antibody Formation; Antimalarials; BCG Vaccine; Disease Models, Animal; Fibrosis; Humans; I | 2001 |
[Isoniazid-rifampicin: an exemplary hepatotoxicity].
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Humans; Isoniazid; Liver; Micros | 1978 |
Scleral tuberculosis.
Topics: Administration, Topical; Aged; Female; Fluorescein Angiography; Humans; Isoniazid; Necrosis; Radiogr | 1976 |
Granulomatous panniculitis in erythema nodosum.
Topics: Adult; Aged; Aspirin; Caseins; Erythema Induratum; Erythema Nodosum; Female; Follow-Up Studies; Gran | 1975 |
Liver disease caused by medicinal agents.
Topics: Adrenal Cortex Hormones; Analgesics; Chemical and Drug Induced Liver Injury; Cholestasis; Contracept | 1975 |
[Drug induced liver injury. Chemical liver necrosis caused by formation of reactive metabolites].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug | 1976 |
Hydrazine--a possible cause of isoniazid--induced hepatic necrosis.
Topics: Age Factors; Aged; Antitubercular Agents; Humans; Hydrazines; Isoniazid; Liver; Male; Necrosis; Tube | 1992 |
Papulonecrotic tuberculid. Necessity of long-term triple regimens.
Topics: Adolescent; Adult; Antitubercular Agents; Drug Combinations; Ethambutol; Female; Humans; Isoniazid; | 1991 |
Erythema induratum of Bazin as a type of tuberculid.
Topics: Adult; Antigens, Differentiation; Erythema Induratum; Female; Fluorescent Antibody Technique; HLA-DR | 1990 |
Isoniazid-rifampicin-induced submassive hepatic necrosis.
Topics: Chemical and Drug Induced Liver Injury; Female; Hepatic Encephalopathy; Humans; Isoniazid; Liver; Mi | 1989 |
Tuberculous aortitis with associated necrosis and perforation: treatment and options.
Topics: Aged; Aortitis; Combined Modality Therapy; Female; Humans; Isoniazid; Necrosis; Rifampin; Rupture, S | 1986 |
Fetal hepatic necrosis in a woman receiving chemoprophylaxis with isoniazid.
Topics: Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Autopsy; Chemical and Drug Induced Liver Inju | 1973 |
[Liver toxicity of combined rifampicin-isoniazid-ethambutol medication (author's transl)].
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bi | 1974 |
Tuberculin hypersensitivity associated with papulonecrotic tuberculids.
Topics: Adult; Biopsy; Humans; Hypersensitivity; Isoniazid; Male; Mycobacterium tuberculosis; Necrosis; Tube | 1967 |
Report of a case of bilateral caseous tuberculous dacryoadenitis.
Topics: Cheese; Female; Humans; Isoniazid; Lacrimal Apparatus; Middle Aged; Necrosis; Peritonitis, Tuberculo | 1972 |
Acute hepatic necrosis associated with ethionamide.
Topics: Adolescent; Aminosalicylic Acids; Chemical and Drug Induced Liver Injury; Ethionamide; Female; Human | 1968 |
Infection of knee joint by Mycobacterium kansasii.
Topics: Adult; Female; Humans; Isoniazid; Joint Diseases; Knee; Mycobacterium Infections; Necrosis; Synovial | 1965 |
Gold Nanorods and Nanoprisms Mediate Different Photothermal Cell Death Mechanisms In Vitro and In Vivo.
Topics: Animals; Apoptosis; Cell Death; Cell Line, Tumor; Gold; Humans; Hydra; Hyperthermia, Induced; Melano | 2020 |