Page last updated: 2024-10-29

isoniazid and Necrosis

isoniazid has been researched along with Necrosis in 37 studies

Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.
hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"Pharmacokinetic parameters of isoniazid, hydrazine (a metabolite of isoniazid), rifampicin and pyrazinamide in a 74-year-old man with pulmonary tuberculosis who died of submassive hepatic necrosis eight days after starting antituberculosis therapy were compared with those of other elderly patients who did not develop hepatotoxicity."7.68Hydrazine--a possible cause of isoniazid--induced hepatic necrosis. ( Chan, CH; Chan, KK; Walubo, A; Woo, J, 1992)
"Pharmacokinetic parameters of isoniazid, hydrazine (a metabolite of isoniazid), rifampicin and pyrazinamide in a 74-year-old man with pulmonary tuberculosis who died of submassive hepatic necrosis eight days after starting antituberculosis therapy were compared with those of other elderly patients who did not develop hepatotoxicity."3.68Hydrazine--a possible cause of isoniazid--induced hepatic necrosis. ( Chan, CH; Chan, KK; Walubo, A; Woo, J, 1992)
" A potentially toxic INH dose (120 mg/kg) was injected by i."1.42Circadian variation in murine hepatotoxicity to the antituberculosis agent «Isoniazide». ( Aouam, K; Ben-Attia, M; Boughattas, F; Boughattas, NA; Chennoufi, M; Haouas, Z; Maaroufi, K; Miled, A; Reinberg, A; Souayed, N, 2015)
"So we diagnosed her as having intracranial tuberculoma."1.30[A case of intracranial tuberculoma followed by MRI]. ( Hashimoto, Y; Honda, I; Teramoto, H; Uchino, M; Yonemura, K, 1998)
"Eleven cases of papulonecrotic tuberculid (PNT) were seen at the Institute of Dermatology, Bangkok, over a 2-year period (1985 to 1986)."1.28Papulonecrotic tuberculid. Necessity of long-term triple regimens. ( Kullavanijaya, P; Sirimachan, S; Suwantaroj, S, 1991)
"We report three cases of patients with erythema induratum of Bazin who showed extreme tuberculin hypersensitivity reactions and a good therapeutic response to isoniazid."1.28Erythema induratum of Bazin as a type of tuberculid. ( Aiba, S; Kuramoto, Y; Tagami, H, 1990)
"Isoniazid and rifampin were started, but both were stopped by the patient after less than 6 months of therapy."1.27Tuberculous aortitis with associated necrosis and perforation: treatment and options. ( Burns, DK; Cargile, JS; Fisher, DF; Fry, WJ, 1986)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199022 (59.46)18.7374
1990's5 (13.51)18.2507
2000's4 (10.81)29.6817
2010's4 (10.81)24.3611
2020's2 (5.41)2.80

Authors

AuthorsStudies
Zhang, G1
Chen, L1
Wen, Y1
Rao, Z1
Wei, Y1
Wu, X1
Gengenbacher, M1
Duque-Correa, MA1
Kaiser, P1
Schuerer, S1
Lazar, D1
Zedler, U1
Reece, ST1
Nayyar, A1
Cole, ST1
Makarov, V1
Barry Iii, CE1
Dartois, V1
Kaufmann, SHE1
Vazquez-Lopez, F1
Fueyo-Casado, A1
Gonzalez-Lara, L1
Souayed, N1
Chennoufi, M1
Boughattas, F1
Haouas, Z1
Maaroufi, K1
Miled, A1
Ben-Attia, M1
Aouam, K1
Reinberg, A1
Boughattas, NA1
Khan, SR1
Aljuhani, N1
Morgan, AG1
Baghdasarian, A1
Fahlman, RP1
Siraki, AG1
Frank, I1
Lahav, D1
Aroch, I1
Botha, T1
Ryffel, B1
Panchabhai, TS1
Ambarkhane, SV1
Joshi, AS1
Samant, BD1
Rege, NN1
Bondarev, IM1
Ivanov, VL1
Novoselova, VP1
Kovaleva, LA1
Shtegel'man, LA1
Lenders, JW1
Bartelink, AK1
van Herwaarden, CL1
van Haelst, UJ1
van Tongeren, JH1
van der Grient, AJ1
Kelderman, CS1
Maddrey, WC2
Bahri, AK1
Chiang, CS1
Timbrell, JA1
Sarich, TC1
Adams, SP1
Zhou, T1
Wright, JM1
Yonemura, K1
Teramoto, H1
Honda, I1
Hashimoto, Y1
Uchino, M1
Bruña-Romero, O1
González-Aseguinolaza, G1
Hafalla, JC1
Tsuji, M1
Nussenzweig, RS1
Mitchell, JR2
Potter, WZ1
Boitnott, JK1
Berthelot, P1
Nelson, SD1
Thorgeirsson, SS1
McMurtry, RJ1
Dybing, E2
Bloomfield, SE1
Mondino, B1
Gray, GF1
Förström, L1
Winkelmann, RK1
Zimmerman, HJ1
Woo, J1
Chan, CH1
Walubo, A1
Chan, KK1
Kullavanijaya, P1
Sirimachan, S1
Suwantaroj, S1
Kuramoto, Y1
Aiba, S1
Tagami, H1
Kasantikul, V1
Cargile, JS1
Fisher, DF1
Burns, DK1
Fry, WJ1
LaMont, JT1
Bailey, WC1
Thompson, DH1
Carson, B1
Greenberg, HB1
Austerhoff, A1
Kindler, U1
Knop, P1
Knieriem, HJ1
Kent, DC1
Baghdassarian, SA1
Zakharia, H1
Asdourian, KK1
Hollinrake, K1
Godwin, MC1
Moros, M1
Lewinska, A1
Merola, F1
Ferraro, P1
Wnuk, M1
Tino, A1
Tortiglione, C1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase 1b/2a Safety and Immunogenicity of the DNMT Inhibitor Azacitidine During Anti-Tuberculosis Therapy[NCT03941496]Phase 1/Phase 20 participants (Actual)Interventional2022-10-31Withdrawn (stopped due to The study was halted prematurely due to Bristol-Myers Squibb's (BMS) decision to withdraw support for this study.)
A Phase Ib Safety and Immunogenicity Clinical Trial of Heterologous Prime-boost Immunisation With ChAd3-EBO Z and MVA-EBO Z in Healthy Senegalese Adult Volunteers Aged 18-50 Years.[NCT02485912]Phase 140 participants (Actual)Interventional2015-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Safety and Tolerability of Administration of ChAd3-EBO Z and MVA-EBO Z 7 Days Later. This Will be Done by Recording the Number of Participants Who Experience Adverse Events and the Severity of Any Adverse Events.

"The specific endpoints for safety and reactogenicity will be actively and passively collected data on adverse events.~The following parameters will be assessed for both groups:~Occurrence of solicited local reactogenicity signs and symptoms for 7 days following the vaccination~Occurrence of solicited systemic reactogenicity signs and symptoms for 7 days following the vaccination~Occurrence of unsolicited adverse events for 28 days following the vaccination~Change from baseline for safety laboratory measures~Occurrence of serious adverse events during the whole study duration" (NCT02485912)
Timeframe: 26 weeks

Interventionparticipants (Number)
Group 120
Group 220

To Assess the Immunogenicity Generated by Heterologous Prime-boost Immunisation With Monovalent ChAd3-EBO Z (2.5 x 1010 vp - 3.7 x 1010vp) and MVA-EBO Z (1.0 x 108 Pfu) in Healthy Senegalese Volunteers Aged 18-50 Years

"Ebolavirus specific immunogenicity will be assessed by a variety of immunological assays. The primary immunogenicity outcome measures are ELISA and neutralization antigen-specific assays for antibody responses and intracellular cytokine staining (ICS) assay for T cell responses.~Exploratory outcome measures will include ex-vivo ELISPOT, plasma blast assays and flow cytometry performed with research samples collected at different study timepoints as well as other immunogenicity assays throughout the study. An evaluation of genetic factors associated with immune responses may be performed as exploratory evaluation. Vaccine-induced mRNA expression profiles during 1 week after vaccination may also be performed as an exploratory evaluation." (NCT02485912)
Timeframe: 26 weeks

Interventionparticipants (Number)
Group 120
Group 220

Reviews

5 reviews available for isoniazid and Necrosis

ArticleYear
Drug-related acute and chronic hepatitis.
    Clinics in gastroenterology, 1980, Volume: 9, Issue:1

    Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Hypersen

1980
Drug metabolism in the production of liver injury.
    The Medical clinics of North America, 1975, Volume: 59, Issue:4

    Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur

1975
Drug-induced chronic hepatitis and cirrhosis.
    Progress in liver diseases, 1979, Volume: 6

    Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adve

1979
Metabolic activation: biochemical basis for many drug-induced liver injuries.
    Progress in liver diseases, 1976, Volume: 5

    Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hyp

1976
Postoperative juandice.
    The Surgical clinics of North America, 1974, Volume: 54, Issue:3

    Topics: Aminosalicylic Acids; Anemia, Hemolytic; Bile Ducts; Bilirubin; Chemical and Drug Induced Liver Inju

1974

Other Studies

32 other studies available for isoniazid and Necrosis

ArticleYear
Pyridoxal isonicotinoyl hydrazone inhibition of FXR is involved in the pathogenesis of isoniazid-induced liver injury.
    Toxicology and applied pharmacology, 2020, 09-01, Volume: 402

    Topics: Animals; Apoptosis; Behavior, Animal; Bile Acids and Salts; Chemical and Drug Induced Liver Injury;

2020
NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans.
    Scientific reports, 2017, 08-18, Volume: 7, Issue:1

    Topics: Animals; Antitubercular Agents; Disease Models, Animal; Fibrosis; Foam Cells; Humans; Hypoxia; Isoni

2017
Lupus Vulgaris Erythematoides: report of a patient initially misdiagnosed as dermatitis.
    Dermatology online journal, 2013, May-15, Volume: 19, Issue:5

    Topics: Adrenal Cortex Hormones; Aged, 80 and over; Anti-Bacterial Agents; Antitubercular Agents; Biopsy; Ca

2013
Circadian variation in murine hepatotoxicity to the antituberculosis agent «Isoniazide».
    Chronobiology international, 2015, Volume: 32, Issue:9

    Topics: Animals; Antitubercular Agents; Biomarkers; Chemical and Drug Induced Liver Injury; Circadian Rhythm

2015
Cytoprotective effect of isoniazid against H2O2 derived injury in HL-60 cells.
    Chemico-biological interactions, 2016, Jan-25, Volume: 244

    Topics: Cell Death; Cytoprotection; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Hydrogen Peroxide

2016
Myocardial necrosis and severe metabolic acidosis associated with isoniazid poisoning in a dog.
    The Veterinary record, 2002, Nov-23, Volume: 151, Issue:21

    Topics: Acidosis; Animals; Antitubercular Agents; Dog Diseases; Dogs; Female; Isoniazid; Liver; Myocardium;

2002
Reactivation of latent tuberculosis infection in TNF-deficient mice.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Sep-15, Volume: 171, Issue:6

    Topics: Animals; Cell Migration Inhibition; Chemokines; Down-Regulation; Granuloma; Isoniazid; Lymphocyte Ac

2003
Protective effect of Tinospora cordifolia, Phyllanthus emblica and their combination against antitubercular drugs induced hepatic damage: an experimental study.
    Phytotherapy research : PTR, 2008, Volume: 22, Issue:5

    Topics: Animals; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; I

2008
[Effectiveness of the rapid intravenous administration of rifampicin and isoniazid and of the intramuscular administration of streptomycin in disseminated destructive pulmonary tuberculosis in dogs].
    Antibiotiki, 1984, Volume: 29, Issue:6

    Topics: Animals; Dogs; Drug Evaluation, Preclinical; Drug Therapy, Combination; Guinea Pigs; Injections, Int

1984
[Fatal liver cell necrosis following short-term administration of isoniazid and rifampicin to a patient already under treatment with antiepileptics].
    Nederlands tijdschrift voor geneeskunde, 1983, Mar-05, Volume: 127, Issue:10

    Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Interactions; Hepatic Encephalopathy;

1983
[Fatal liver cell necrosis after short-term administration of isoniazid and rifampicin to a patient already under treatment with anti-epileptic agents].
    Nederlands tijdschrift voor geneeskunde, 1983, May-21, Volume: 127, Issue:21

    Topics: Adult; Carbamazepine; Female; Hepatic Encephalopathy; Humans; Isoniazid; Liver; Necrosis; Rifampin

1983
Factors affecting acetylhydrazine hepatotoxicity.
    Advances in experimental medicine and biology, 1981, Volume: 136 Pt B

    Topics: Animals; Cytochrome P-450 Enzyme System; Hydrazines; Isoniazid; Liver; Male; Necrosis; Phenobarbital

1981
Isoniazid-induced hepatic necrosis and steatosis in rabbits: absence of effect of gender.
    Canadian journal of physiology and pharmacology, 1997, Volume: 75, Issue:9

    Topics: Animals; Antitubercular Agents; Argininosuccinate Lyase; Fatty Liver; Female; Hypertriglyceridemia;

1997
[A case of intracranial tuberculoma followed by MRI].
    Rinsho shinkeigaku = Clinical neurology, 1998, Volume: 38, Issue:1

    Topics: Antitubercular Agents; Brain; Female; Follow-Up Studies; Humans; Isoniazid; Magnetic Resonance Imagi

1998
Complete, long-lasting protection against malaria of mice primed and boosted with two distinct viral vectors expressing the same plasmodial antigen.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Sep-25, Volume: 98, Issue:20

    Topics: Animals; Antibody Formation; Antimalarials; BCG Vaccine; Disease Models, Animal; Fibrosis; Humans; I

2001
[Isoniazid-rifampicin: an exemplary hepatotoxicity].
    Gastroenterologie clinique et biologique, 1978, Volume: 2, Issue:2

    Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Humans; Isoniazid; Liver; Micros

1978
Scleral tuberculosis.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1976, Volume: 94, Issue:6

    Topics: Administration, Topical; Aged; Female; Fluorescein Angiography; Humans; Isoniazid; Necrosis; Radiogr

1976
Granulomatous panniculitis in erythema nodosum.
    Archives of dermatology, 1975, Volume: 111, Issue:3

    Topics: Adult; Aged; Aspirin; Caseins; Erythema Induratum; Erythema Nodosum; Female; Follow-Up Studies; Gran

1975
Liver disease caused by medicinal agents.
    The Medical clinics of North America, 1975, Volume: 59, Issue:4

    Topics: Adrenal Cortex Hormones; Analgesics; Chemical and Drug Induced Liver Injury; Cholestasis; Contracept

1975
[Drug induced liver injury. Chemical liver necrosis caused by formation of reactive metabolites].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Feb-10, Volume: 96, Issue:4

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug

1976
Hydrazine--a possible cause of isoniazid--induced hepatic necrosis.
    Journal of medicine, 1992, Volume: 23, Issue:1

    Topics: Age Factors; Aged; Antitubercular Agents; Humans; Hydrazines; Isoniazid; Liver; Male; Necrosis; Tube

1992
Papulonecrotic tuberculid. Necessity of long-term triple regimens.
    International journal of dermatology, 1991, Volume: 30, Issue:7

    Topics: Adolescent; Adult; Antitubercular Agents; Drug Combinations; Ethambutol; Female; Humans; Isoniazid;

1991
Erythema induratum of Bazin as a type of tuberculid.
    Journal of the American Academy of Dermatology, 1990, Volume: 22, Issue:4

    Topics: Adult; Antigens, Differentiation; Erythema Induratum; Female; Fluorescent Antibody Technique; HLA-DR

1990
Isoniazid-rifampicin-induced submassive hepatic necrosis.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1989, Volume: 72, Issue:1

    Topics: Chemical and Drug Induced Liver Injury; Female; Hepatic Encephalopathy; Humans; Isoniazid; Liver; Mi

1989
Tuberculous aortitis with associated necrosis and perforation: treatment and options.
    Journal of vascular surgery, 1986, Volume: 4, Issue:6

    Topics: Aged; Aortitis; Combined Modality Therapy; Female; Humans; Isoniazid; Necrosis; Rifampin; Rupture, S

1986
Fetal hepatic necrosis in a woman receiving chemoprophylaxis with isoniazid.
    The American journal of gastroenterology, 1973, Volume: 59, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Autopsy; Chemical and Drug Induced Liver Inju

1973
[Liver toxicity of combined rifampicin-isoniazid-ethambutol medication (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1974, May-31, Volume: 99, Issue:22

    Topics: Adolescent; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bi

1974
Tuberculin hypersensitivity associated with papulonecrotic tuberculids.
    The American review of respiratory disease, 1967, Volume: 96, Issue:2

    Topics: Adult; Biopsy; Humans; Hypersensitivity; Isoniazid; Male; Mycobacterium tuberculosis; Necrosis; Tube

1967
Report of a case of bilateral caseous tuberculous dacryoadenitis.
    American journal of ophthalmology, 1972, Volume: 74, Issue:4

    Topics: Cheese; Female; Humans; Isoniazid; Lacrimal Apparatus; Middle Aged; Necrosis; Peritonitis, Tuberculo

1972
Acute hepatic necrosis associated with ethionamide.
    British journal of diseases of the chest, 1968, Volume: 62, Issue:3

    Topics: Adolescent; Aminosalicylic Acids; Chemical and Drug Induced Liver Injury; Ethionamide; Female; Human

1968
Infection of knee joint by Mycobacterium kansasii.
    JAMA, 1965, Oct-04, Volume: 194, Issue:1

    Topics: Adult; Female; Humans; Isoniazid; Joint Diseases; Knee; Mycobacterium Infections; Necrosis; Synovial

1965
Gold Nanorods and Nanoprisms Mediate Different Photothermal Cell Death Mechanisms In Vitro and In Vivo.
    ACS applied materials & interfaces, 2020, Mar-25, Volume: 12, Issue:12

    Topics: Animals; Apoptosis; Cell Death; Cell Line, Tumor; Gold; Humans; Hydra; Hyperthermia, Induced; Melano

2020