A pyruvate kinase PKM that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14618]
EC 2.7.1.40;
Cytosolic thyroid hormone-binding protein;
CTHBP;
Opa-interacting protein 3;
OIP-3;
Pyruvate kinase 2/3;
Pyruvate kinase muscle isozyme;
Thyroid hormone-binding protein 1;
THBP1;
Tumor M2-PK;
p58
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| spermidine | Homo sapiens (human) | IC50 | 1.4100 | 1 | 1 |
| indoprofen | Homo sapiens (human) | IC50 | 21.0000 | 1 | 1 |
| vitamin k 3 | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| nalidixic acid | Homo sapiens (human) | IC50 | 53.0000 | 1 | 1 |
| gliotoxin | Homo sapiens (human) | IC50 | 22.6400 | 1 | 1 |
| vitamin k5 | Homo sapiens (human) | IC50 | 28.0000 | 1 | 1 |
| hematoxylin | Homo sapiens (human) | IC50 | 340.0000 | 1 | 1 |
| syringic acid | Homo sapiens (human) | IC50 | 13.8000 | 1 | 1 |
| 3-hydroxyflavone | Homo sapiens (human) | IC50 | 1.7500 | 1 | 1 |
| 3-hydroxyflavone | Homo sapiens (human) | Ki | 3.5300 | 1 | 1 |
| 5-hydroxyflavone | Homo sapiens (human) | IC50 | 1.3900 | 1 | 1 |
| 5-hydroxyflavone | Homo sapiens (human) | Ki | 3.5300 | 1 | 1 |
| epicatechin | Homo sapiens (human) | IC50 | 1.3300 | 1 | 1 |
| 6-hydroxyflavone | Homo sapiens (human) | IC50 | 1.2400 | 1 | 1 |
| 6-hydroxyflavone | Homo sapiens (human) | Ki | 3.5300 | 1 | 1 |
| alkannin | Homo sapiens (human) | IC50 | 0.9000 | 2 | 2 |
| neoeriocitrin | Homo sapiens (human) | IC50 | 0.6500 | 1 | 1 |
| oxymatrine | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| tanshinone ii a | Homo sapiens (human) | IC50 | 1,920.0000 | 1 | 1 |
| taxifolin | Homo sapiens (human) | IC50 | 1.1600 | 1 | 1 |
| ferulic acid | Homo sapiens (human) | IC50 | 11.4000 | 1 | 1 |
| shikonin | Homo sapiens (human) | IC50 | 7.9600 | 8 | 8 |
| apigenin | Homo sapiens (human) | IC50 | 0.9900 | 2 | 2 |
| fisetin | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| scutellarein | Homo sapiens (human) | IC50 | 41.6667 | 3 | 3 |
| wogonin | Homo sapiens (human) | IC50 | 2.0100 | 1 | 1 |
| wogonin | Homo sapiens (human) | Ki | 3.5300 | 1 | 1 |
| polydatin | Homo sapiens (human) | IC50 | 128.0000 | 1 | 1 |
| 7-hydroxyflavone | Homo sapiens (human) | IC50 | 2.1200 | 1 | 1 |
| 7-hydroxyflavone | Homo sapiens (human) | Ki | 3.5300 | 1 | 1 |
| (-)-catechin-3-O-gallate | Homo sapiens (human) | IC50 | 0.8500 | 1 | 1 |
This protein enables 10 target(s):
| Target | Category | Definition |
|---|---|---|
| magnesium ion binding | molecular function | Binding to a magnesium (Mg) ion. [GOC:ai] |
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| mRNA binding | molecular function | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. [GOC:kmv, GOC:pr, SO:0000234] |
| protein tyrosine kinase activity | molecular function | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [RHEA:10596] |
| pyruvate kinase activity | molecular function | Catalysis of the reaction: = ADP + H+ + phosphoenolpyruvate => ATP + pyruvate. [EC:2.7.1.40, RHEA:18159] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| MHC class II protein complex binding | molecular function | Binding to a class II major histocompatibility complex. [GOC:mtg_signal, GOC:vw] |
| potassium ion binding | molecular function | Binding to a potassium ion (K+). [GOC:mah] |
| cadherin binding | molecular function | Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf] |
This protein is located in 13 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| rough endoplasmic reticulum | cellular component | The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. [ISBN:0198506732] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| cilium | cellular component | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] |
| vesicle | cellular component | Any small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles] |
| secretory granule lumen | cellular component | The volume enclosed by the membrane of a secretory granule. [GOC:rph] |
| collagen-containing extracellular matrix | cellular component | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| extracellular vesicle | cellular component | Any vesicle that is part of the extracellular region. [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] |
| ficolin-1-rich granule lumen | cellular component | Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| programmed cell death | biological process | A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. [GOC:lr, GOC:mtg_apoptosis] |
| canonical glycolysis | biological process | The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP. [GOC:dph, ISBN:0201090910, ISBN:0879010479] |
| positive regulation of sprouting angiogenesis | biological process | Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:16756958] |
| positive regulation of cytoplasmic translation | biological process | Any process that activates or increases the frequency, rate or extent of cytoplasmic translation. [GOC:obol] |
| glycolytic process | biological process | The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] |
| cellular response to insulin stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732] |