Proteins > Nitric oxide synthase, endothelial
Page last updated: 2024-08-07 16:23:14
Nitric oxide synthase, endothelial
[no definition available]
Synonyms
EC 1.14.13.39;
Constitutive NOS;
cNOS;
EC-NOS;
Endothelial NOS;
eNOS;
NOS type III;
NOSIII
Research
Bioassay Publications (12)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| epicatechin | Bos taurus (cattle) | EC50 | 0.0020 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| arginine | Bos taurus (cattle) | Activity | 25.0000 | 1 | 1 |
| arginine | Bos taurus (cattle) | Km | 1.1000 | 1 | 1 |
Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma.European journal of medicinal chemistry, , May-25, Volume: 152, 2018
Selective Acetamidine-Based Nitric Oxide Synthase Inhibitors: Synthesis, Docking, and Biological Studies.ACS medicinal chemistry letters, , Jun-11, Volume: 6, Issue:6, 2015
N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 20, Issue:22, 2010
Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.European journal of medicinal chemistry, , Volume: 44, Issue:7, 2009
Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.Bioorganic & medicinal chemistry, , Jun-01, Volume: 16, Issue:11, 2008
Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by Bioorganic & medicinal chemistry, , 05-15, Volume: 25, Issue:10, 2017
Synthesis of a series of 3,4-methanoarginines as side-chain conformationally restricted analogues of arginine.Bioorganic & medicinal chemistry, , Oct-15, Volume: 19, Issue:20, 2011
Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.Journal of medicinal chemistry, , Nov-11, Volume: 53, Issue:21, 2010
Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water.Journal of medicinal chemistry, , May-03, Volume: 50, Issue:9, 2007
Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.Journal of medicinal chemistry, , Jul-02, Volume: 41, Issue:14, 1998