60 kDa heat shock protein, mitochondrial

A 60 kDa heat shock protein, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10809]

Synonyms

EC 5.6.1.7;
60 kDa chaperonin;
Chaperonin 60;
CPN60;
Heat shock protein 60;
HSP-60;
Hsp60;
HuCHA60;
Mitochondrial matrix protein P1;
P60 lymphocyte protein

Research

Bioassay Publications (4)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	4 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (62)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
4-nonylphenol	Homo sapiens (human)	IC50	9.5000	1	1
albuterol	Homo sapiens (human)	IC50	100.0000	1	1
aurintricarboxylic acid	Homo sapiens (human)	IC50	3.2000	1	1
benzbromarone	Homo sapiens (human)	IC50	9.1000	1	1
bithionol	Homo sapiens (human)	IC50	2.8000	1	1
candesartan	Homo sapiens (human)	IC50	100.0000	1	1
eflornithine	Homo sapiens (human)	IC50	175.0000	2	2
dichlorophen	Homo sapiens (human)	IC50	17.0000	1	1
ethacrynic acid	Homo sapiens (human)	IC50	8.5000	1	1
harmalol	Homo sapiens (human)	IC50	100.0000	1	1
hexachlorophene	Homo sapiens (human)	IC50	1.3000	1	1
beta-lapachone	Homo sapiens (human)	IC50	2.1000	1	1
vitamin k 3	Homo sapiens (human)	IC50	15.0000	1	1
mesalamine	Homo sapiens (human)	IC50	12.0000	1	1
pentamidine	Homo sapiens (human)	IC50	175.0000	2	2
primaquine	Homo sapiens (human)	IC50	100.0000	1	1
protoporphyrin ix	Homo sapiens (human)	IC50	4.9000	1	1
cetrimonium bromide	Homo sapiens (human)	IC50	7.4000	1	1
ampicillin	Homo sapiens (human)	IC50	100.0000	1	1
purpurin	Homo sapiens (human)	IC50	23.0000	1	1
salicylanilide	Homo sapiens (human)	IC50	100.0000	1	1
benzanilide	Homo sapiens (human)	IC50	100.0000	1	1
benzethonium chloride	Homo sapiens (human)	IC50	23.0000	1	1
evans blue	Homo sapiens (human)	IC50	0.1700	1	1
lithocholic acid	Homo sapiens (human)	IC50	10.0000	1	1
plumbagin	Homo sapiens (human)	IC50	6.3000	1	1
gentian violet	Homo sapiens (human)	IC50	5.8000	1	1
erythromycin	Homo sapiens (human)	IC50	100.0000	1	1
agaric acid	Homo sapiens (human)	IC50	4.0000	1	1
ethidium bromide	Homo sapiens (human)	IC50	100.0000	1	1
vancomycin	Homo sapiens (human)	IC50	100.0000	1	1
cetylpyridinium chloride	Homo sapiens (human)	IC50	6.0000	1	1
rafoxanide	Homo sapiens (human)	IC50	2.8000	1	1
paclitaxel	Homo sapiens (human)	IC50	100.0000	1	1
closantel	Homo sapiens (human)	IC50	2.6500	2	2
adapalene	Homo sapiens (human)	IC50	2.3000	1	1
epigallocatechin gallate	Homo sapiens (human)	IC50	2.3000	1	1
sb 204070a	Homo sapiens (human)	IC50	100.0000	1	1
gossypol acetic acid	Homo sapiens (human)	IC50	1.2000	1	1
tretinoin	Homo sapiens (human)	IC50	5.3000	1	1
arachidonic acid	Homo sapiens (human)	IC50	4.5000	1	1
riboflavin	Homo sapiens (human)	IC50	100.0000	1	1
4'-methoxychalcone	Homo sapiens (human)	IC50	16.0000	1	1
4-chloro-3-nitro-1-(phenylmethyl)-2-quinolinone	Homo sapiens (human)	IC50	126.4000	2	2
curcumin	Homo sapiens (human)	IC50	8.3000	1	1
gossypetin	Homo sapiens (human)	IC50	7.5000	1	1
vitamin d 2	Homo sapiens (human)	IC50	45.0000	1	1
cholecalciferol	Homo sapiens (human)	IC50	11.0000	1	1
morin	Homo sapiens (human)	IC50	11.0000	1	1
4-hydroxychalcone	Homo sapiens (human)	IC50	22.0000	1	1
4'-hydroxychalcone	Homo sapiens (human)	IC50	20.0000	1	1
phenoxybenzamine hydrochloride	Homo sapiens (human)	IC50	78.0000	1	1
nalbuphine	Homo sapiens (human)	IC50	100.0000	1	1
22,23-dihydroavermectin b(1)a	Homo sapiens (human)	IC50	16.0000	1	1
avermectin b(1)a	Homo sapiens (human)	IC50	15.0000	1	1
nifurtimox	Homo sapiens (human)	IC50	175.0000	2	2
erythrosine	Homo sapiens (human)	IC50	2.9000	1	1
tannins	Homo sapiens (human)	IC50	3.8000	1	1
ly-146032	Homo sapiens (human)	IC50	100.0000	1	1
6-o-palmitoylascorbic acid	Homo sapiens (human)	IC50	3.1000	1	1
rifampin	Homo sapiens (human)	IC50	100.0000	1	1
hematein	Homo sapiens (human)	IC50	3.6000	1	1

Enables

This protein enables 18 target(s):

Target	Category	Definition
lipopolysaccharide binding	molecular function	Binding to a lipopolysaccharide. [PMID:11079463]
p53 binding	molecular function	Binding to one of the p53 family of proteins. [GOC:hjd]
DNA replication origin binding	molecular function	Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. [GOC:curators]
single-stranded DNA binding	molecular function	Binding to single-stranded DNA. [GOC:elh, GOC:vw, PMID:22976174]
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
double-stranded RNA binding	molecular function	Binding to double-stranded RNA. [GOC:jl]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
high-density lipoprotein particle binding	molecular function	Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE. [GOC:mah]
isomerase activity	molecular function	Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. [ISBN:0198506732]
ATP hydrolysis activity	molecular function	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
ubiquitin protein ligase binding	molecular function	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp]
apolipoprotein binding	molecular function	Binding to an apolipoprotein, the protein component of a lipoprotein complex. [GOC:BHF, GOC:rl]
apolipoprotein A-I binding	molecular function	Binding to apolipoprotein A-I. [GOC:BHF, GOC:rl]
unfolded protein binding	molecular function	Binding to an unfolded protein. [GOC:ai]
protein-folding chaperone binding	molecular function	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. [PMID:10585443]
ATP-dependent protein folding chaperone	molecular function	Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis. [PMID:27365453]

Located In

This protein is located in 17 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
mitochondrial inner membrane	cellular component	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]
mitochondrial matrix	cellular component	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732]
early endosome	cellular component	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
clathrin-coated pit	cellular component	A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
coated vesicle	cellular component	Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. [ISBN:0815316194]
secretory granule	cellular component	A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. [GOC:mah, ISBN:0198506732]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
sperm midpiece	cellular component	The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. [GOC:cjm, MP:0009831]
sperm plasma membrane	cellular component	A plasma membrane that is part of a sperm cell. [GOC:cjm]
migrasome	cellular component	A vesicular organelle that forms on retraction fibers behind migrating cells and mediates the release of cytoplasmic contents during cell migration. [PMID:25342562, PMID:31371827]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
mitochondrial matrix	cellular component	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732]
mitochondrial inner membrane	cellular component	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
protein-containing complex	cellular component	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]
lipopolysaccharide receptor complex	cellular component	A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens. [PMID:11706042, PMID:9665271]

Involved In

This protein is involved in 29 target(s):

Target	Category	Definition
MyD88-dependent toll-like receptor signaling pathway	biological process	A toll-like receptor signaling pathway in which the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
positive regulation of T cell mediated immune response to tumor cell	biological process	Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell. [GOC:add]
'de novo' protein folding	biological process	The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. [GOC:mb]
activation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
response to unfolded protein	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus. [GOC:jl]
response to cold	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. [GOC:lr]
positive regulation of interferon-alpha production	biological process	Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. [GOC:mah, PMID:15546383]
positive regulation of type II interferon production	biological process	Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]
positive regulation of interleukin-10 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. [GOC:mah]
positive regulation of interleukin-12 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. [GOC:mah]
positive regulation of interleukin-6 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. [GOC:mah]
protein refolding	biological process	The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. [GOC:mb]
B cell proliferation	biological process	The expansion of a B cell population by cell division. Follows B cell activation. [GOC:jl]
B cell activation	biological process	The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149]
positive regulation of macrophage activation	biological process	Any process that stimulates, induces or increases the rate of macrophage activation. [GOC:jl]
positive regulation of apoptotic process	biological process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
isotype switching to IgG isotypes	biological process	The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus. [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655]
protein stabilization	biological process	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai]
positive regulation of T cell activation	biological process	Any process that activates or increases the frequency, rate or extent of T cell activation. [GOC:ai]
chaperone-mediated protein complex assembly	biological process	The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. [GOC:ai]
protein maturation	biological process	Any process leading to the attainment of the full functional capacity of a protein. [GOC:ai]
biological process involved in interaction with symbiont	biological process	An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. [GOC:cc]
cellular response to interleukin-7	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus. [GOC:BHF, GOC:mah]
T cell activation	biological process	The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149]
protein import into mitochondrial intermembrane space	biological process	The import of proteins into the space between the inner and outer mitochondrial membranes. [ISBN:0716731363]
protein folding	biological process	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. [GOC:go_curators, GOC:rb]
mitochondrial unfolded protein response	biological process	The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in transcriptional upregulation of nuclear genes encoding mitochondrial stress proteins. [GOC:mah, PMID:17849004]
apoptotic mitochondrial changes	biological process	The morphological and physiological alterations undergone by mitochondria during apoptosis. [GOC:mah, GOC:mtg_apoptosis]