A glutathione hydrolase 1 proenzyme that is encoded in the genome of human. [PRO:CNA, UniProtKB:P19440]
EC 3.4.19.13;
Gamma-glutamyltransferase 1;
Gamma-glutamyltranspeptidase 1;
GGT 1;
2.3.2.2;
Leukotriene-C4 hydrolase;
3.4.19.14
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| aspirin | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| peptidyltransferase activity | molecular function | Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme. [PMID:11433365, PMID:9242921] |
| leukotriene-C(4) hydrolase | molecular function | Catalysis of the reaction leukotriene C(4) + H2O= leukotriene D(4) + L-glutamate. [PMID:9774450, RHEA:31563] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| glutathione hydrolase activity | molecular function | Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. [EC:3.4.19.13, GOC:imk] |
| leukotriene C4 gamma-glutamyl transferase activity | molecular function | Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid. [GOC:pz, PMID:1676842, PMID:9139674] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is involved in 14 target(s):
| Target | Category | Definition |
|---|---|---|
| regulation of immune system process | biological process | Any process that modulates the frequency, rate, or extent of an immune system process. [GOC:add] |
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |
| amino acid metabolic process | biological process | The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. [ISBN:0198506732] |
| glutamate metabolic process | biological process | The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. [GOC:go_curators] |
| fatty acid metabolic process | biological process | The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684] |
| leukotriene metabolic process | biological process | The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. [GOC:ma] |
| glutathione biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. [GOC:ai, GOC:al, GOC:pde, ISBN:0198506732] |
| glutathione catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. [GOC:ai, ISBN:0198506732] |
| spermatogenesis | biological process | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821] |
| cysteine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. [GOC:go_curators] |
| zymogen activation | biological process | The proteolytic processing of an inactive enzyme to an active form. [GOC:hjd] |
| regulation of inflammatory response | biological process | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. [GOC:ai] |
| leukotriene D4 biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of leukotriene D4. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00880] |
| peptide modification | biological process | The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide. [GOC:mah] |