A neuromedin-U receptor 2 that is encoded in the genome of human. [PRO:CNx, Reactome:R-HSA-964816]
Synthesis and ACS medicinal chemistry letters, , May-10, Volume: 9, Issue:5, 2018
Development of potent and proteolytically stable human neuromedin U receptor agonists.European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
A potent neuromedin U receptor 2-selective alkylated peptide.Bioorganic & medicinal chemistry letters, , 10-15, Volume: 27, Issue:20, 2017
Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide.Journal of medicinal chemistry, , 07-27, Volume: 60, Issue:14, 2017
| Target | Category | Definition |
|---|
| neuromedin U receptor activity | molecular function | Combining with neuromedin U to initiate a change in cell activity. [GOC:ai] |
| G protein-coupled receptor activity | molecular function | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] |
| intracellularly calcium-gated chloride channel activity | molecular function | Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, PMID:29236691] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| GTP binding | molecular function | Binding to GTP, guanosine triphosphate. [GOC:ai] |
| neuromedin U binding | molecular function | Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses. [GOC:jl, PMID:12584108] |
| neuropeptide receptor activity | molecular function | Combining with a neuropeptide to initiate a change in cell activity. [GOC:ai] |
| Target | Category | Definition |
|---|
| reduction of food intake in response to dietary excess | biological process | An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients. [GOC:pg, GOC:pr, PMID:12161655, PMID:12840200] |
| regulation of smooth muscle contraction | biological process | Any process that modulates the frequency, rate or extent of smooth muscle contraction. [GOC:go_curators] |
| phospholipase C-activating G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] |
| neuropeptide signaling pathway | biological process | A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194] |
| cell-cell signaling | biological process | Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah] |
| central nervous system development | biological process | The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. [GOC:bf, GOC:jid, ISBN:0582227089] |
| grooming behavior | biological process | The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. [GOC:jl, GOC:pr] |
| feeding behavior | biological process | Behavior associated with the intake of food. [GOC:mah] |
| response to pain | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. [GOC:jid, PMID:10203867, PMID:12723742, PMID:12843304, Wikipedia:Pain] |
| arachidonic acid secretion | biological process | The controlled release of arachidonic acid from a cell or a tissue. [GOC:ai] |
| positive regulation of calcium-mediated signaling | biological process | Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling. [GOC:ai] |
| chloride transmembrane transport | biological process | The process in which chloride is transported across a membrane. [GOC:TermGenie, GOC:vw] |