Plasminogen activator inhibitor 1

A plasminogen activator inhibitor 1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P05121]

Synonyms

PAI;
PAI-1;
Endothelial plasminogen activator inhibitor;
Serpin E1

Research

Bioassay Publications (8)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (12.50)	18.2507
2000's	5 (62.50)	29.6817
2010's	2 (25.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (9)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
gallic acid	Homo sapiens (human)	IC50	6.6000	1	1
hexachlorophene	Homo sapiens (human)	IC50	3.8000	1	1
1,2,5,8-tetrahydroxy anthraquinone	Homo sapiens (human)	IC50	4.4000	1	1
epigallocatechin gallate	Homo sapiens (human)	IC50	0.0910	1	1
sennoside A	Homo sapiens (human)	IC50	51.0000	1	1
Epigallocatechin 3,5-Digallate	Homo sapiens (human)	IC50	0.3300	1	1
pai 039	Homo sapiens (human)	IC50	9.4889	9	9
xr 334	Homo sapiens (human)	IC50	59.4000	1	1
sideroxylonal c	Homo sapiens (human)	IC50	4.7000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pai 039	Homo sapiens (human)	Kd	15.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pai 039	Homo sapiens (human)	Inhibition	65.0000	2	2

Enables

This protein enables 4 target(s):

Target	Category	Definition
protease binding	molecular function	Binding to a protease or a peptidase. [GOC:hjd]
serine-type endopeptidase inhibitor activity	molecular function	Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase. [GOC:ai]
signaling receptor binding	molecular function	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
platelet alpha granule lumen	cellular component	The volume enclosed by the membrane of the platelet alpha granule. [GOC:mah, PMID:8467233]
collagen-containing extracellular matrix	cellular component	An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
serine protease inhibitor complex	cellular component	A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity. [GOC:ans, PMID:6323392]
peptidase inhibitor complex	cellular component	A protein complex which is capable of peptidase inhibitor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:20860624]

Involved In

This protein is involved in 27 target(s):

Target	Category	Definition
angiogenesis	biological process	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
regulation of signaling receptor activity	biological process	Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. [GOC:dph, GOC:tb]
negative regulation of plasminogen activation	biological process	Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. [GOC:BHF, GOC:dph, GOC:tb]
negative regulation of endopeptidase activity	biological process	Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. [GOC:dph, GOC:tb]
negative regulation of smooth muscle cell migration	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. [CL:0000192, GOC:mtg_muscle]
positive regulation of blood coagulation	biological process	Any process that activates or increases the frequency, rate or extent of blood coagulation. [GOC:mah]
negative regulation of blood coagulation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation. [GOC:mah]
negative regulation of cell migration	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. [GOC:go_curators]
positive regulation of interleukin-8 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. [GOC:mah]
negative regulation of cell adhesion mediated by integrin	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin. [GOC:add]
positive regulation of leukotriene production involved in inflammatory response	biological process	Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response. [GOC:bf]
fibrinolysis	biological process	A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. [GOC:jl, PMID:15842654]
positive regulation of angiogenesis	biological process	Any process that activates or increases angiogenesis. [GOC:go_curators]
positive regulation of receptor-mediated endocytosis	biological process	Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. [GOC:go_curators, GOC:tb]
positive regulation of inflammatory response	biological process	Any process that activates or increases the frequency, rate or extent of the inflammatory response. [GOC:ai]
defense response to Gram-negative bacterium	biological process	Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. [GOC:ai]
negative regulation of fibrinolysis	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. [GOC:ai]
negative regulation of vascular wound healing	biological process	Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. [GOC:BHF, GOC:dph]
negative regulation of wound healing	biological process	Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. [GOC:dph]
cellular response to lipopolysaccharide	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
positive regulation of monocyte chemotaxis	biological process	Any process that increases the frequency, rate, or extent of monocyte chemotaxis. [GOC:dph, GOC:tb]
replicative senescence	biological process	A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging. [GOC:BHF]
dentinogenesis	biological process	The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin. [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346]
positive regulation of odontoblast differentiation	biological process	Any process that activates or increases the frequency, rate or extent of odontoblast differentiation. [GOC:TermGenie]
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. [GOC:TermGenie, PMID:17245429]
negative regulation of smooth muscle cell-matrix adhesion	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell-matrix adhesion. [GOC:BHF]
negative regulation of endothelial cell apoptotic process	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]