Proteins > Neuronal acetylcholine receptor subunit beta-2
Page last updated: 2024-08-07 15:56:24

Neuronal acetylcholine receptor subunit beta-2

A neuronal acetylcholine receptor subunit beta-2 that is encoded in the genome of rat. [OMA:P12390, PRO:DNx]

Synonyms

Neuronal acetylcholine receptor non-alpha-1 chain;
N-alpha 1

Research

Bioassay Publications (107)

TimeframeStudies on this Protein(%)All Drugs %
pre-19902 (1.87)18.7374
1990's14 (13.08)18.2507
2000's40 (37.38)29.6817
2010's49 (45.79)24.3611
2020's2 (1.87)2.80

Compounds (731)

Drugs with Potency Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4-methylumbelliferyl acetateRattus norvegicus (Norway rat)Potency35.481310
niacinRattus norvegicus (Norway rat)Potency3.548110
ro 5-4864Rattus norvegicus (Norway rat)Potency31.622810
acridoneRattus norvegicus (Norway rat)Potency39.810710
alfuzosinRattus norvegicus (Norway rat)Potency35.481310
amlexanoxRattus norvegicus (Norway rat)Potency35.481310
astemizoleRattus norvegicus (Norway rat)Potency50.118710
butacaineRattus norvegicus (Norway rat)Potency0.158510
carvedilolRattus norvegicus (Norway rat)Potency11.220210
dibucaineRattus norvegicus (Norway rat)Potency11.220210
dipyridamoleRattus norvegicus (Norway rat)Potency11.220210
4-biphenylylacetic acidRattus norvegicus (Norway rat)Potency12.589310
fluspirileneRattus norvegicus (Norway rat)Potency5.011910
harmalineRattus norvegicus (Norway rat)Potency22.387210
indoprofenRattus norvegicus (Norway rat)Potency0.177810
avaproRattus norvegicus (Norway rat)Potency0.446710
lansoprazoleRattus norvegicus (Norway rat)Potency12.589310
meclofenamate sodium anhydrousRattus norvegicus (Norway rat)Potency11.220210
vitamin k 3Rattus norvegicus (Norway rat)Potency56.234110
propazineRattus norvegicus (Norway rat)Potency39.810710
riluzoleRattus norvegicus (Norway rat)Potency5.623410
terazosinRattus norvegicus (Norway rat)Potency25.118910
terfenadineRattus norvegicus (Norway rat)Potency56.234110
triamtereneRattus norvegicus (Norway rat)Potency39.810710
ethinyl estradiolRattus norvegicus (Norway rat)Potency12.589310
chlorpromazine hydrochlorideRattus norvegicus (Norway rat)Potency56.234110
lidocaine hydrochlorideRattus norvegicus (Norway rat)Potency56.234110
2,4-dihydroxybenzophenoneRattus norvegicus (Norway rat)Potency1.412510
quinestrolRattus norvegicus (Norway rat)Potency56.234110
fluorometholoneRattus norvegicus (Norway rat)Potency0.177810
imperatorinRattus norvegicus (Norway rat)Potency28.183810
aminacrineRattus norvegicus (Norway rat)Potency28.183810
amiloride hydrochloride, anhydrousRattus norvegicus (Norway rat)Potency28.183810
beclomethasoneRattus norvegicus (Norway rat)Potency5.623410
6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinolineRattus norvegicus (Norway rat)Potency35.481310
metergolineRattus norvegicus (Norway rat)Potency56.234110
moricizine hydrochlorideRattus norvegicus (Norway rat)Potency3.548110
proroxan hydrochlorideRattus norvegicus (Norway rat)Potency50.118710
picobenzideRattus norvegicus (Norway rat)Potency5.011910
acarboseRattus norvegicus (Norway rat)Potency4.466810
terazosin hydrochloride anhydrousRattus norvegicus (Norway rat)Potency39.810710
chaetochrominRattus norvegicus (Norway rat)Potency31.622810
castanospermineRattus norvegicus (Norway rat)Potency11.220210
aripiprazoleRattus norvegicus (Norway rat)Potency1.778310
duloxetineRattus norvegicus (Norway rat)Potency50.118710
tobramycin sulfateRattus norvegicus (Norway rat)Potency11.220210
doxazosin mesylateRattus norvegicus (Norway rat)Potency39.810710
pyrrolo(1,2-a)quinoxalineRattus norvegicus (Norway rat)Potency31.622810
11h-pyrido(2,1-b)quinazolin-11-oneRattus norvegicus (Norway rat)Potency31.622810
prazosin hydrochlorideRattus norvegicus (Norway rat)Potency19.952610
miconazole nitrateRattus norvegicus (Norway rat)Potency50.118710
econazole nitrateRattus norvegicus (Norway rat)Potency56.234110
5,6-benzocoumarin-3-carboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency35.481310
labetalol hydrochlorideRattus norvegicus (Norway rat)Potency1.778310
maprotiline hydrochlorideRattus norvegicus (Norway rat)Potency2.511910
nodakeninRattus norvegicus (Norway rat)Potency35.481310
EvoxineRattus norvegicus (Norway rat)Potency56.234110
p-Aminosalicylic acid methyl esterRattus norvegicus (Norway rat)Potency12.589310
8-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency35.481310
2-(1H-benzimidazol-2-yl)anilineRattus norvegicus (Norway rat)Potency22.387210
4-nitrophenyl dimethylcarbamateRattus norvegicus (Norway rat)Potency56.234110
4-methylumbelliferyl butyrateRattus norvegicus (Norway rat)Potency35.481310
pd 147953Rattus norvegicus (Norway rat)Potency0.316210
1,8-bis(dimethylamino)naphthaleneRattus norvegicus (Norway rat)Potency0.891310
prilocaine hydrochlorideRattus norvegicus (Norway rat)Potency3.981110
columbianetin, (s)-isomerRattus norvegicus (Norway rat)Potency35.481310
7-amino-4-methylcoumarinRattus norvegicus (Norway rat)Potency35.481310
meclizine hydrochlorideRattus norvegicus (Norway rat)Potency50.118710
1-(4'-nitrophenyl)-2-aminopropane-1,3-diolRattus norvegicus (Norway rat)Potency11.220210
cortisol octanoateRattus norvegicus (Norway rat)Potency11.220210
methylene bis(methylanthranilate)Rattus norvegicus (Norway rat)Potency14.125410
7-amino-4-trifluoromethylcoumarinRattus norvegicus (Norway rat)Potency15.848910
2-(4-phenylphenoxy)propanoic acidRattus norvegicus (Norway rat)Potency44.668410
bicuculline methiodideRattus norvegicus (Norway rat)Potency3.162310
N-(1,3-dioxo-4-isoindolyl)acetamideRattus norvegicus (Norway rat)Potency56.234110
butyroxanRattus norvegicus (Norway rat)Potency0.158510
2,4-dinitropyrimidinyl-2-thiophenolRattus norvegicus (Norway rat)Potency11.220210
1-benzylimidazole-4,5-dicarboxylic acidRattus norvegicus (Norway rat)Potency56.234110
3-chloro-7-methoxy-4-methyl-1-benzopyran-2-oneRattus norvegicus (Norway rat)Potency56.234110
tosifenRattus norvegicus (Norway rat)Potency19.952610
1-(1-pyrrolidinylmethyl)-2-naphtholRattus norvegicus (Norway rat)Potency1.122010
gossypol acetic acidRattus norvegicus (Norway rat)Potency44.668410
ml 204Rattus norvegicus (Norway rat)Potency17.782810
6-methyl-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrileRattus norvegicus (Norway rat)Potency31.622810
5-(2-naphthalenylmethylidene)-1,3-diazinane-2,4,6-trioneRattus norvegicus (Norway rat)Potency3.981110
1',3'-dimethylspiro[1H-indole-3,8'-7,9-dihydropurine]-2,2',6'-trioneRattus norvegicus (Norway rat)Potency3.162310
n-acetylhistidineRattus norvegicus (Norway rat)Potency50.118710
2-quinolinecarboxylic acid (4-nitrophenyl) esterRattus norvegicus (Norway rat)Potency44.668410
3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency17.782810
6-dimethylaminopurine arabinosideRattus norvegicus (Norway rat)Potency11.220210
1-methyl-3-phenylpyrazino[1,2-a]benzimidazoleRattus norvegicus (Norway rat)Potency25.118910
5,7-dimethoxy-4-methyl-1-benzopyran-2-oneRattus norvegicus (Norway rat)Potency50.118710
N-malonylanthranilic acidRattus norvegicus (Norway rat)Potency11.220210
miglitolRattus norvegicus (Norway rat)Potency3.548110
vicenin iiRattus norvegicus (Norway rat)Potency35.481310
3-Furan-3-yl-3a,7-dimethyl-3a,4,5,6-tetrahydro-3H-isobenzofuran-1-oneRattus norvegicus (Norway rat)Potency35.481310
2-chloro-N-(5-methyl-3-isoxazolyl)acetamideRattus norvegicus (Norway rat)Potency2.818410
2-(3-oxo-4H-quinoxalin-2-yl)propanoic acid ethyl esterRattus norvegicus (Norway rat)Potency44.668410
hei 713Rattus norvegicus (Norway rat)Potency4.466810
2-amino-3-cyano-5,6,7,8-tetrahydroquinoline-4-carboxylic acid methyl esterRattus norvegicus (Norway rat)Potency31.622810
1,3-dichloro-7-methyl-6,8-dihydro-5H-2,7-naphthyridine-4-carbonitrileRattus norvegicus (Norway rat)Potency35.481310
2,3-diphenyl-6-quinoxalinecarboxylic acidRattus norvegicus (Norway rat)Potency35.481310
xanthoangelolRattus norvegicus (Norway rat)Potency0.177810
6-amino-2-methyl-8-phenyl-1,6,8,8a-tetrahydroisoquinoline-5,7,7-tricarbonitrileRattus norvegicus (Norway rat)Potency25.118910
2-imino-N,8-dimethyl-5-oxo-1-propan-2-yl-3-dipyrido[1,2-d-3',4'-f]pyrimidinecarboxamideRattus norvegicus (Norway rat)Potency8.912510
1-[2,5-diethoxy-4-(1-tetrazolyl)phenyl]sulfonyl-4-(4-fluorophenyl)-3,6-dihydro-2H-pyridineRattus norvegicus (Norway rat)Potency1.584910
n-2-fluorenesulfonyl-beta-alanineRattus norvegicus (Norway rat)Potency50.118710
2-[[2-(1-benzotriazolyl)-1-oxoethyl]-(thiophen-2-ylmethyl)amino]-2-(2-furanyl)-N-(3-methylbutyl)acetamideRattus norvegicus (Norway rat)Potency31.622810
2-[[3-(1H-benzimidazol-2-yl)-2-pyridinyl]thio]acetic acid methyl esterRattus norvegicus (Norway rat)Potency56.234110
1-[(1-tert-butyl-5-tetrazolyl)-thiophen-2-ylmethyl]-4-(2,3-dimethylphenyl)piperazineRattus norvegicus (Norway rat)Potency39.810710
2-[2,2-dimethyl-6-[4-morpholinyl(oxo)methyl]-3-oxo-1,4-benzoxazin-4-yl]-N-phenylacetamideRattus norvegicus (Norway rat)Potency31.622810
N-cyclopentyl-4-[[4-[2-furanyl(oxo)methyl]-1-piperazinyl]sulfonyl]benzenesulfonamideRattus norvegicus (Norway rat)Potency14.125410
3-[(1-tert-butyl-5-tetrazolyl)-[2-furanylmethyl(2-oxolanylmethyl)amino]methyl]-6-methoxy-1H-quinolin-2-oneRattus norvegicus (Norway rat)Potency22.387210
1-(1,3-benzodioxol-5-ylmethyl)-3-hydroxy-3-[2-(4-methylphenyl)-2-oxoethyl]-2-indoloneRattus norvegicus (Norway rat)Potency28.183810
6-ethyl-3-[[[1-(2-furanylmethyl)-5-tetrazolyl]methyl-(phenylmethyl)amino]methyl]-1H-quinolin-2-oneRattus norvegicus (Norway rat)Potency56.234110
3-(benzenesulfonyl)-2-imino-1-(2-oxolanylmethyl)-5-dipyrido[1,2-d-3',4'-f]pyrimidinoneRattus norvegicus (Norway rat)Potency0.794310
2-(1-benzimidazolylmethyl)-5-[(4-chlorophenyl)methylthio]-1,3,4-oxadiazoleRattus norvegicus (Norway rat)Potency8.912510
7-[[1-(2-oxolanylmethyl)-5-tetrazolyl]-(1-pyrrolidinyl)methyl]-5H-[1,3]dioxolo[4,5-g]quinolin-6-oneRattus norvegicus (Norway rat)Potency35.481310
2-[[3-cyano-6-(2-furanyl)-4-(trifluoromethyl)-2-pyridinyl]thio]propanoic acid ethyl esterRattus norvegicus (Norway rat)Potency35.481310
N-tert-butyl-2-(2-furanyl)-2-[[2-[5-(5-methyl-2-furanyl)-2-tetrazolyl]-1-oxoethyl]-(thiophen-2-ylmethyl)amino]acetamideRattus norvegicus (Norway rat)Potency35.481310
[5-(2-furanyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinyl]-[4-(2-pyridinyl)-1-piperazinyl]methanoneRattus norvegicus (Norway rat)Potency5.011910
N'-[1-[(cyclohexylamino)-oxomethyl]cyclopentyl]-N-(5-methyl-3-isoxazolyl)-N'-phenylbutanediamideRattus norvegicus (Norway rat)Potency39.810710
4-[2-(3-fluorophenyl)-5-methyl-7-pyrazolo[1,5-a]pyrimidinyl]morpholineRattus norvegicus (Norway rat)Potency28.183810
8-[2-(4-methoxyphenyl)-5-phenyl-7-pyrazolo[1,5-a]pyrimidinyl]-1,4-dioxa-8-azaspiro[4.5]decaneRattus norvegicus (Norway rat)Potency50.118710
3-[2-hydroxyethyl-[(6-methoxy-2-oxo-1H-quinolin-3-yl)methyl]sulfamoyl]benzoic acid ethyl esterRattus norvegicus (Norway rat)Potency50.118710
4-[[[[8-[(1-tert-butyl-5-tetrazolyl)methyl]-8-azabicyclo[3.2.1]octan-3-yl]amino]-oxomethyl]amino]benzoic acid ethyl esterRattus norvegicus (Norway rat)Potency56.234110
2-[(2,3-dimethyl-7,8,9,10-tetrahydrophenanthridin-6-yl)thio]-N-(4-methyl-1,2,5-oxadiazol-3-yl)acetamideRattus norvegicus (Norway rat)Potency39.810710
1-(3-cyano-7-methoxy-2-quinolinyl)-4-piperidinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency56.234110
N-cyclopropyl-4-(2,3-dihydroindol-1-ylsulfonyl)benzenesulfonamideRattus norvegicus (Norway rat)Potency12.589310
N-(2-furanylmethyl)-2-(2-oxo-1,3-benzothiazol-3-yl)acetamideRattus norvegicus (Norway rat)Potency11.220210
2-[4-(benzenesulfonyl)phenyl]-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazoleRattus norvegicus (Norway rat)Potency31.622810
N-[2,5-diethoxy-4-[[oxo-(3,4,5-trimethoxyphenyl)methyl]amino]phenyl]-2-furancarboxamideRattus norvegicus (Norway rat)Potency35.481310
3-chloro-4-[4-(4-fluorophenyl)sulfonyl-1-piperazinyl]-N,N-dimethylbenzenesulfonamideRattus norvegicus (Norway rat)Potency14.125410
3-[[(1-tert-butyl-5-tetrazolyl)methyl-(thiophen-2-ylmethyl)amino]methyl]-6-ethoxy-1H-quinolin-2-oneRattus norvegicus (Norway rat)Potency50.118710
1-[1-[[1-[(4-methylphenyl)methyl]-5-tetrazolyl]methyl]-4-piperidinyl]-5-(trifluoromethyl)benzotriazoleRattus norvegicus (Norway rat)Potency44.668410
3-[1-azepanyl-[1-[(4-fluorophenyl)methyl]-5-tetrazolyl]methyl]-6,7-dimethoxy-1H-quinolin-2-oneRattus norvegicus (Norway rat)Potency31.622810
N-[(6,7-dimethoxy-2-oxo-1H-quinolin-3-yl)methyl]-N-(3-hydroxypropyl)benzenesulfonamideRattus norvegicus (Norway rat)Potency50.118710
1-(3-methoxyphenyl)-2-[[4-methyl-5-[[(4-phenyl-2-thiazolyl)amino]methyl]-1,2,4-triazol-3-yl]thio]ethanoneRattus norvegicus (Norway rat)Potency3.981110
4-methyl-6-(methylthio)-1H-quinolin-2-oneRattus norvegicus (Norway rat)Potency56.234110
2-[[4-(3,4-dimethoxyphenyl)-6-(trifluoromethyl)-2-pyrimidinyl]thio]-N-(5-methyl-3-isoxazolyl)acetamideRattus norvegicus (Norway rat)Potency50.118710
1-[(5,8-dimethyl-2-oxo-1H-quinolin-3-yl)methyl]-1-(2-furanylmethyl)-3-phenylureaRattus norvegicus (Norway rat)Potency14.125410
4-amino-N5-[1-(2-furanyl)-2-(3-methylbutylamino)-2-oxoethyl]-N5-(2-methoxyphenyl)isothiazole-3,5-dicarboxamideRattus norvegicus (Norway rat)Potency50.118710
1-[5-(2-amino-5-methyl-4-thiazolyl)-2,3-dihydroindol-1-yl]-1-butanoneRattus norvegicus (Norway rat)Potency5.623410
N-[4-(diethylsulfamoyl)phenyl]-2-(2-oxo-1,3-benzothiazol-3-yl)acetamideRattus norvegicus (Norway rat)Potency50.118710
2-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-2-phenylacetonitrileRattus norvegicus (Norway rat)Potency0.354810
3-[[4-(1-benzotriazolyl)-1-piperidinyl]sulfonyl]-N-cyclopentylbenzenesulfonamideRattus norvegicus (Norway rat)Potency17.782810
N,N-dimethyl-4-[[4-(5-methyl-1-benzotriazolyl)-1-piperidinyl]sulfonyl]benzamideRattus norvegicus (Norway rat)Potency39.810710
N-[4-(4-fluorophenyl)-2-thiazolyl]-2-[(4-methylphenyl)sulfonylamino]benzamideRattus norvegicus (Norway rat)Potency50.118710
4-methoxy-N1,N3-bis(3-pyridinyl)benzene-1,3-dicarboxamideRattus norvegicus (Norway rat)Potency6.309610
3,7-dimethyl-1-(phenylmethyl)-8-[(phenylmethyl)amino]purine-2,6-dioneRattus norvegicus (Norway rat)Potency50.118710
1-cyclohexyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-amineRattus norvegicus (Norway rat)Potency35.481310
6-ethyl-6-methyl-5,8-dihydro-1H-thiopyrano[2,3]thieno[2,4-b]pyrimidine-2,4-dioneRattus norvegicus (Norway rat)Potency35.481310
2-amino-7-cyclohexyl-6,8-dioxo-4,5,5a,8a-tetrahydrothieno[2,3-e]isoindole-3-carboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency39.810710
5-(4-morpholinylsulfonyl)-1H-indole-3-carboxylic acidRattus norvegicus (Norway rat)Potency39.810710
3-amino-5-methyl-4-[[3-(4-morpholinyl)propylamino]-oxomethyl]-2-thiophenecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency31.622810
LSM-19776Rattus norvegicus (Norway rat)Potency35.481310
3-(phenylmethyl)-1H-quinoxalin-2-oneRattus norvegicus (Norway rat)Potency25.118910
4-chlorobenzoic acid 2-(2-amino-3-cyano-1-pyrrolo[3,2-b]quinoxalinyl)ethyl esterRattus norvegicus (Norway rat)Potency2.238710
2-[[3-cyano-4-(2-furanyl)-5,6,7,8-tetrahydroquinolin-2-yl]thio]-N-(2-methylphenyl)acetamideRattus norvegicus (Norway rat)Potency50.118710
2-[[(4-chloro-1-methyl-3-pyrazolyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid methyl esterRattus norvegicus (Norway rat)Potency25.118910
2-[(6-amino-3,5-dicyano-4-thiophen-2-yl-2-pyridinyl)thio]-N-(2-phenylethyl)acetamideRattus norvegicus (Norway rat)Potency50.118710
2-(4-chlorophenyl)-5-(1-piperidinyl)-4-oxazolecarbonitrileRattus norvegicus (Norway rat)Potency31.622810
2-[2-[(1-phenyl-4-pyrazolo[3,4-d]pyrimidinyl)amino]ethoxy]ethanolRattus norvegicus (Norway rat)Potency50.118710
1-methyl-2-[(phenylthio)methyl]-3-indolecarbonitrileRattus norvegicus (Norway rat)Potency39.810710
LSM-23818Rattus norvegicus (Norway rat)Potency22.387210
5-bromo-N-(2-pyridinylmethyl)-2-thiophenesulfonamideRattus norvegicus (Norway rat)Potency11.220210
2-[5-[(2,4-dichlorophenyl)methylthio]-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]pyridineRattus norvegicus (Norway rat)Potency31.622810
6-(4-methoxyphenyl)-3-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoleRattus norvegicus (Norway rat)Potency50.118710
8-[4-(3-chlorophenyl)-1-piperazinyl]-3-methyl-7-pentylpurine-2,6-dioneRattus norvegicus (Norway rat)Potency50.118710
N-[(6-methoxy-2-oxo-1H-quinolin-3-yl)methyl]-N-methyl-4-pyridinecarboxamideRattus norvegicus (Norway rat)Potency0.891310
2-(4-methoxyphenyl)-3-propylimidazo[4,5-b]quinoxalineRattus norvegicus (Norway rat)Potency28.183810
N-[3-(2-furanylmethylamino)-2-quinoxalinyl]-3-methylbenzenesulfonamideRattus norvegicus (Norway rat)Potency50.118710
5-[(4-fluorophenyl)methylamino]-2-(2-methoxyphenyl)-4-oxazolecarbonitrileRattus norvegicus (Norway rat)Potency44.668410
2-methoxy-N-[(6-methoxy-2-oxo-1H-quinolin-3-yl)methyl]-N-(2-methoxyphenyl)acetamideRattus norvegicus (Norway rat)Potency50.118710
1-(thiophen-2-ylmethyl)-3-thiophen-2-ylsulfonyl-2-pyrrolo[3,2-b]quinoxalinamineRattus norvegicus (Norway rat)Potency28.183810
N-butyl-N-[(6-methoxy-2-oxo-1H-quinolin-3-yl)methyl]-2-pyridinecarboxamideRattus norvegicus (Norway rat)Potency28.183810
3-[[2-(3,5-dimethyl-1-pyrazolyl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]amino]-1-propanolRattus norvegicus (Norway rat)Potency19.952610
2-amino-4-(2-furanyl)-6-(2-pyridinyl)-3-pyridinecarbonitrileRattus norvegicus (Norway rat)Potency28.183810
1-[1-oxo-2-[(4-oxo-2,3-dihydro-1H-cyclopenta[c][1]benzopyran-7-yl)oxy]ethyl]-4-piperidinecarboxylic acidRattus norvegicus (Norway rat)Potency50.118710
7-(3,5-dimethyl-1-pyrazolyl)-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidineRattus norvegicus (Norway rat)Potency1.122010
N-(4,6-dimethyl-2-pyrimidinyl)-1,3-bis(phenylmethyl)-2,4-dihydro-1,3,5-triazin-6-amineRattus norvegicus (Norway rat)Potency1.778310
7-butyl-8-[[4-(3-chlorophenyl)-1-piperazinyl]methyl]-1,3-dimethylpurine-2,6-dioneRattus norvegicus (Norway rat)Potency70.794610
3-(1,3-benzodioxol-5-ylmethyl)-4,10-dihydro-2H-[1,3,5]triazino[1,2-a]benzimidazoleRattus norvegicus (Norway rat)Potency19.952610
LSM-33283Rattus norvegicus (Norway rat)Potency35.481310
1-(4-fluorophenyl)-2-[[4-(2-furanylmethyl)-5-(phenoxymethyl)-1,2,4-triazol-3-yl]thio]ethanoneRattus norvegicus (Norway rat)Potency5.623410
dienestrolRattus norvegicus (Norway rat)Potency28.183810
2-[(2-ethoxy-2-oxoethyl)thio]-1-benzimidazolecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency7.943310
5-thiophen-2-yl-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidineRattus norvegicus (Norway rat)Potency28.183810
1-(diethylamino)-3-methyl-4-pyrido[1,2-a]benzimidazolecarbonitrileRattus norvegicus (Norway rat)Potency8.912510
4-methoxy-N-(3-pyridinylmethyl)benzamideRattus norvegicus (Norway rat)Potency7.943310
2-methoxy-N-(2-pyridinyl)benzamideRattus norvegicus (Norway rat)Potency4.466810
1-(4-amino-1,2,5-oxadiazol-3-yl)-5-(phenoxymethyl)-4-triazolecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency50.118710
6-(2-methyl-3-benzofuranyl)-2,3-dihydroimidazo[2,1-b]thiazoleRattus norvegicus (Norway rat)Potency12.589310
iFSP1Rattus norvegicus (Norway rat)Potency28.183810
2-mercaptobenzoxazoleRattus norvegicus (Norway rat)Potency7.079510
(3,5-dimethoxyphenyl)-(4-methylsulfonyl-1-piperazinyl)methanoneRattus norvegicus (Norway rat)Potency11.220210
1-(1,3-benzothiazol-2-yl)-3-phenylureaRattus norvegicus (Norway rat)Potency0.100010
2-[[oxo(phenoxy)methyl]amino]benzene-1,4-dicarboxylic acid dimethyl esterRattus norvegicus (Norway rat)Potency31.622810
N-(5-acetyl-4-methyl-2-thiazolyl)-2-methylpropanamideRattus norvegicus (Norway rat)Potency1.778310
N-[[(6-methyl-1,3-benzothiazol-2-yl)amino]-sulfanylidenemethyl]-2-thiophenecarboxamideRattus norvegicus (Norway rat)Potency11.220210
3-[(6-methyl-4-phenyl-2-quinazolinyl)amino]propanoic acidRattus norvegicus (Norway rat)Potency31.622810
4-[2-(1-methyl-2-benzimidazolyl)ethyl]anilineRattus norvegicus (Norway rat)Potency50.118710
2-[(5-anilino-4-phenyl-4H-1,2,4-triazol-3-yl)thio]acetic acidRattus norvegicus (Norway rat)Potency50.118710
4-methyl-2-(2-naphthalenyl)-1-phthalazinoneRattus norvegicus (Norway rat)Potency5.623410
7,7-dimethyl-2-(1-pyrrolidinyl)-5,8-dihydropyrano[4,3-b]pyridine-3-carbonitrileRattus norvegicus (Norway rat)Potency35.481310
2-methyl-N-(1-methyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-yl)propanamideRattus norvegicus (Norway rat)Potency35.481310
N-[2-(1-cyclohexenyl)ethyl]-3-(2-oxo-1,3-benzothiazol-3-yl)propanamideRattus norvegicus (Norway rat)Potency31.622810
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-methoxybenzamideRattus norvegicus (Norway rat)Potency56.234110
3-(4-methylphenyl)sulfonyl-1,3-benzoxazol-2-oneRattus norvegicus (Norway rat)Potency3.548110
4-anilino-4-oxobutanoic acid (4-tert-butylcyclohexyl) esterRattus norvegicus (Norway rat)Potency35.481310
1-(1,3-benzodioxol-5-ylmethyl)-3-(2-methylphenyl)thioureaRattus norvegicus (Norway rat)Potency0.251210
1-(1,3-benzodioxol-5-ylmethyl)-3-(2,5-dimethylphenyl)thioureaRattus norvegicus (Norway rat)Potency56.234110
2-[[4-amino-2-(ethylamino)-5-thiazolyl]-phenylmethylidene]propanedinitrileRattus norvegicus (Norway rat)Potency35.481310
1-[(1,3-benzodioxol-5-ylmethylamino)-sulfanylidenemethyl]-4-piperidinecarboxamideRattus norvegicus (Norway rat)Potency0.794310
6-(1,3-benzoxazol-2-yl)-1,3-benzothiazol-2-amineRattus norvegicus (Norway rat)Potency50.118710
2-(hydroxymethyl)-N-(phenylmethyl)benzamideRattus norvegicus (Norway rat)Potency11.220210
3-propyl-1-(2-pyridinylmethylamino)-4-pyrido[1,2-a]benzimidazolecarbonitrileRattus norvegicus (Norway rat)Potency35.481310
N-(3-phenyl-1,3-benzothiazol-2-ylidene)-2-propenamideRattus norvegicus (Norway rat)Potency39.810710
4-phenyl-N-(2-pyridinyl)butanamideRattus norvegicus (Norway rat)Potency1.000010
2-phenyl-1H-quinazoline-4-thioneRattus norvegicus (Norway rat)Potency7.943310
4-(3-methylphenyl)-3-(5-propyl-3-thiophenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency19.952610
N6-ethyl-N4-propan-2-yl-N2-(1,2,4-triazol-4-yl)-1,3,5-triazine-2,4,6-triamineRattus norvegicus (Norway rat)Potency28.183810
3-(1,3-benzodioxol-5-yl)-4-(2,5-dimethylphenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency50.118710
1-[2-(2-chlorophenoxy)ethyl]benzimidazoleRattus norvegicus (Norway rat)Potency44.668410
N-[[6-cyano-5-(ethylamino)-3-methyl-2-pyrazinyl]methyl]-N-phenylacetamideRattus norvegicus (Norway rat)Potency31.622810
acetic acid [2-(4-acetamido-6-phenyl-1,3,5-triazin-2-yl)phenyl] esterRattus norvegicus (Norway rat)Potency1.258910
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-4-methylbenzamideRattus norvegicus (Norway rat)Potency28.183810
5-(1-methyl-2-benzimidazolyl)-2-thiophenecarboxaldehydeRattus norvegicus (Norway rat)Potency39.810710
4-(4-morpholinylmethyl)-3-quinolinolRattus norvegicus (Norway rat)Potency31.622810
2-amino-9-ethyl-3-pyrido[2,3-b]indolecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency25.118910
N-(2-fluoro-5-nitrophenyl)-2,2-dimethylbutanamideRattus norvegicus (Norway rat)Potency7.079510
N-[(2-methoxyphenyl)methyl]-4-(1-piperidinyl)anilineRattus norvegicus (Norway rat)Potency28.183810
5-(4-morpholinyl)-2-thiophen-2-yl-4-oxazolecarbonitrileRattus norvegicus (Norway rat)Potency6.309610
5-amino-3-ethyl-1-phenyl-4-pyrazolecarbonitrileRattus norvegicus (Norway rat)Potency11.220210
5-hydroxy-2-[[(4-methylphenyl)thio]methyl]-3-benzofurancarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency39.810710
7-methoxy-2-oxo-1-benzopyran-3-carboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency31.622810
7,8-dichloropyrido[1,2-a]benzimidazoleRattus norvegicus (Norway rat)Potency25.118910
2-(2-furanyl)-3-(4-methylphenyl)imidazo[4,5-b]quinoxalineRattus norvegicus (Norway rat)Potency4.466810
2-[(3-chloro-1-benzothiophen-2-yl)methylideneamino]phenolRattus norvegicus (Norway rat)Potency56.234110
3-amino-4-thiophen-2-yl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxylic acid methyl esterRattus norvegicus (Norway rat)Potency11.220210
2-(2-fluorophenyl)-5-(4-methoxyanilino)-4-oxazolecarbonitrileRattus norvegicus (Norway rat)Potency44.668410
1-(4-methyl-2-oxo-1-benzopyran-7-yl)-3-(2-pyridinylmethyl)thioureaRattus norvegicus (Norway rat)Potency44.668410
N-(3-chloro-4-methoxyphenyl)-4,6-dimethoxy-1,3,5-triazin-2-amineRattus norvegicus (Norway rat)Potency50.118710
7-amino-2-(4-tert-butylphenyl)-6-pyrazolo[1,5-a]pyrimidinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency1.995310
2-[(3,5-dimethyl-4-isoxazolyl)methylthio]-3-prop-2-enyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-oneRattus norvegicus (Norway rat)Potency39.810710
N-(1-ethyl-2-benzimidazolyl)-5-[(4-methyl-2-nitrophenoxy)methyl]-2-furancarboxamideRattus norvegicus (Norway rat)Potency14.125410
5-[(2,4-dichlorophenoxy)methyl]-N-(2-fluorophenyl)-2-furancarboxamideRattus norvegicus (Norway rat)Potency0.891310
2-(3-pyridinyl)-4-[4-(1-pyrrolidinylsulfonyl)phenyl]thiazoleRattus norvegicus (Norway rat)Potency35.481310
(4-anilino-1,1-dioxo-2H-1$l^{6},2-benzothiazin-3-yl)-phenylmethanoneRattus norvegicus (Norway rat)Potency35.481310
2-[3-(4-methoxyphenyl)-1-benzo[f]quinolinyl]acetic acid ethyl esterRattus norvegicus (Norway rat)Potency25.118910
1-cyclopropyl-4-[4-(trifluoromethyl)phenyl]-4H-pyridine-3,5-dicarboxylic acid dimethyl esterRattus norvegicus (Norway rat)Potency31.622810
1-methoxy-N-[4-(pyridin-4-ylmethyl)phenyl]-2-naphthalenecarboxamideRattus norvegicus (Norway rat)Potency39.810710
1-(3,4-dichlorophenyl)-3-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)ureaRattus norvegicus (Norway rat)Potency0.891310
4-[[[3-(4-morpholinylsulfonyl)phenyl]-oxomethyl]amino]benzoic acid ethyl esterRattus norvegicus (Norway rat)Potency50.118710
2-[[3-cyano-6-(2-furanyl)-4-(trifluoromethyl)-2-pyridinyl]thio]-N,N-diethylacetamideRattus norvegicus (Norway rat)Potency14.125410
2-(2,4,5-trimethoxyphenyl)-1,3-benzothiazoleRattus norvegicus (Norway rat)Potency35.481310
N-[4-(1-piperidinylsulfonyl)phenyl]-2-thiophenesulfonamideRattus norvegicus (Norway rat)Potency0.794310
4-[[2-(phenylmethyl)-1-benzimidazolyl]sulfonyl]morpholineRattus norvegicus (Norway rat)Potency28.183810
3-(1-piperidinylsulfonyl)-N-(2-thiazolyl)benzamideRattus norvegicus (Norway rat)Potency28.183810
N-[4-[[2-(4-hydroxyphenyl)-1,3-dioxo-5-isoindolyl]oxy]phenyl]-2-thiophenecarboxamideRattus norvegicus (Norway rat)Potency56.234110
N-(6-acetyl-1,3-benzodioxol-5-yl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]acetamideRattus norvegicus (Norway rat)Potency12.589310
3-[[4-(1,3-benzodioxol-5-yl)-6-(trifluoromethyl)-2-pyrimidinyl]thio]-N-(2-furanylmethyl)propanamideRattus norvegicus (Norway rat)Potency35.481310
N-(2-furanylmethyl)-4-(1-pyrrolidinylsulfonyl)benzenesulfonamideRattus norvegicus (Norway rat)Potency12.589310
2-methyl-N-(3-methylphenyl)-3-imidazo[1,2-a]pyridinecarboxamideRattus norvegicus (Norway rat)Potency0.177810
4-(benzenesulfonyl)-N-methyl-N-phenyl-1-piperazinecarboxamideRattus norvegicus (Norway rat)Potency35.481310
N-(2-ethylphenyl)-2-[[2-(4-methoxyphenyl)-4-oxo-1-benzopyran-6-yl]oxy]acetamideRattus norvegicus (Norway rat)Potency39.810710
4-(4-ethoxycarbonylanilino)-2-quinazolinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency12.589310
LSM-16526Rattus norvegicus (Norway rat)Potency39.810710
N-(benzenesulfonyl)-N-(4-methoxyphenyl)-3-pyridinecarboxamideRattus norvegicus (Norway rat)Potency5.623410
N-[[3-chloro-2-(1-piperidinyl)anilino]-sulfanylidenemethyl]-2-thiophenecarboxamideRattus norvegicus (Norway rat)Potency17.782810
N-(1,3-benzodioxol-5-yl)-6-bromo-2-pyrazolo[1,5-a]pyrimidinecarboxamideRattus norvegicus (Norway rat)Potency14.125410
N-[2-(4-acetyl-1-piperazinyl)phenyl]-2-(5-methyl-2-propan-2-ylphenoxy)acetamideRattus norvegicus (Norway rat)Potency50.118710
6-amino-1-[2-(3,4-dimethoxyphenyl)ethyl]-2-sulfanylidene-4-pyrimidinoneRattus norvegicus (Norway rat)Potency44.668410
1-(4-chloro-2,5-dimethoxyphenyl)sulfonylbenzotriazoleRattus norvegicus (Norway rat)Potency56.234110
N-[[2-(4-morpholinyl)anilino]-sulfanylidenemethyl]-4-nitrobenzamideRattus norvegicus (Norway rat)Potency11.220210
2-(1,3-benzothiazol-2-ylthio)-N-(4-methylphenyl)sulfonylacetamideRattus norvegicus (Norway rat)Potency0.794310
2-[[(3,5-dimethoxyphenyl)-oxomethyl]amino]-4,5-dimethoxybenzoic acid methyl esterRattus norvegicus (Norway rat)Potency35.481310
N-[5-[(4-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-5-methyl-3-phenyl-4-isoxazolecarboxamideRattus norvegicus (Norway rat)Potency8.912510
2-[[4-(1,3-dioxo-2-isoindolyl)-1-oxobutyl]amino]-N-(2-furanylmethyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamideRattus norvegicus (Norway rat)Potency44.668410
1-(1-azepanyl)-2-(2-bromo-4-propan-2-ylphenoxy)ethanoneRattus norvegicus (Norway rat)Potency0.177810
N-(2-furanylmethyl)-2-[[[2-[(4-methylphenyl)sulfonyl-(phenylmethyl)amino]phenyl]-oxomethyl]amino]benzamideRattus norvegicus (Norway rat)Potency1.995310
3-[[[[[5-(4-chlorophenyl)-2-furanyl]-oxomethyl]amino]-sulfanylidenemethyl]amino]-4-methoxybenzoic acidRattus norvegicus (Norway rat)Potency39.810710
N-(2-furanylmethyl)-2-[[oxo-(3,4,5-trimethoxyphenyl)methyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamideRattus norvegicus (Norway rat)Potency28.183810
[2-(4-methoxyphenyl)-6-methyl-4-quinolinyl]-(4-morpholinyl)methanoneRattus norvegicus (Norway rat)Potency22.387210
N-[3-[[2-(2-bromo-4,6-dimethylphenoxy)-1-oxoethyl]amino]phenyl]-2-furancarboxamideRattus norvegicus (Norway rat)Potency50.118710
7-[4-(4-acetamidophenyl)sulfonyl-1-piperazinyl]-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylic acidRattus norvegicus (Norway rat)Potency28.183810
N-(2-phenyl-5-benzotriazolyl)-2,3-dihydro-1,4-benzodioxin-6-carboxamideRattus norvegicus (Norway rat)Potency50.118710
2-(8-methoxy-2-methyl-4-oxo-1-quinolinyl)-N-(2-methoxyphenyl)acetamideRattus norvegicus (Norway rat)Potency56.234110
N-(4-methoxyphenyl)-2-(3-nitrophenyl)-4-quinazolinamineRattus norvegicus (Norway rat)Potency28.183810
2-[5-(2-aminophenyl)-2-tetrazolyl]-1-[4-(4-methoxyphenyl)-1-piperazinyl]ethanoneRattus norvegicus (Norway rat)Potency56.234110
5,6-dimethyl-2-[1-[[1-(phenylmethyl)-5-tetrazolyl]methyl]-4-piperidinyl]-1H-benzimidazoleRattus norvegicus (Norway rat)Potency35.481310
2-(3-chlorophenyl)-9-[4-(2-pyrazinyl)-1-piperazinyl]-5,6,7,8-tetrahydropyrazolo[5,1-b]quinazolineRattus norvegicus (Norway rat)Potency22.387210
N'-[2-[[1-(4-methylphenyl)-4-pyrazolo[3,4-d]pyrimidinyl]thio]-1-oxoethyl]-2-furancarbohydrazideRattus norvegicus (Norway rat)Potency1.412510
7-methoxy-2-[4-[(2-methylphenyl)-oxomethyl]-1-piperazinyl]-3-quinolinecarbonitrileRattus norvegicus (Norway rat)Potency25.118910
N-[(4-fluorophenyl)methyl]-N-[(8-methyl-2-oxo-1H-quinolin-3-yl)methyl]-4-morpholinecarboxamideRattus norvegicus (Norway rat)Potency22.387210
(2,6-difluorophenyl)-[4-(5-fluoro-2-methyl-1-benzimidazolyl)-1-piperidinyl]methanoneRattus norvegicus (Norway rat)Potency44.668410
2-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]thio]-7-(4-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidineRattus norvegicus (Norway rat)Potency31.622810
6-(4-fluorophenyl)-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrileRattus norvegicus (Norway rat)Potency35.481310
3-[5-[(4-chlorophenyl)methylthio]-1,3,4-oxadiazol-2-yl]-1-(phenylmethyl)-2-pyridinoneRattus norvegicus (Norway rat)Potency39.810710
2-[2-(2,4-dichloro-5-propan-2-yloxyanilino)-2-oxoethyl]sulfinyl-N-[3-(trifluoromethyl)phenyl]acetamideRattus norvegicus (Norway rat)Potency39.810710
4-[2-[(3,4-dichlorophenyl)methylthio]-6-[(methylthio)methyl]-4-pyrimidinyl]morpholineRattus norvegicus (Norway rat)Potency28.183810
6-(4-methyl-1-piperazinyl)-2-(3,4,5-trimethoxyphenyl)-1H-benzimidazoleRattus norvegicus (Norway rat)Potency50.118710
6-tert-butyl-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrileRattus norvegicus (Norway rat)Potency35.481310
3-(5-chloro-1,3-benzoxazol-2-yl)-N-(phenylmethyl)-2-pyridinamineRattus norvegicus (Norway rat)Potency17.782810
1,1-bis(4-chlorophenyl)-2-[(3-methoxyphenyl)methylamino]ethanolRattus norvegicus (Norway rat)Potency50.118710
(4-chlorophenyl)-[4-[[(2,4-dichlorophenyl)thio]methyl]-4-hydroxy-1-piperidinyl]methanoneRattus norvegicus (Norway rat)Potency44.668410
2-(4-fluorophenyl)-1-indolizinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency35.481310
LSM-18426Rattus norvegicus (Norway rat)Potency39.810710
4-(1-benzimidazolyl)-5-(4-methylphenyl)thieno[2,3-d]pyrimidineRattus norvegicus (Norway rat)Potency7.079510
2-chloro-1-[1-(2-furanylmethyl)-2,5-dimethyl-3-pyrrolyl]ethanoneRattus norvegicus (Norway rat)Potency50.118710
LSM-19448Rattus norvegicus (Norway rat)Potency56.234110
cinnarizineRattus norvegicus (Norway rat)Potency11.220210
4-amino-2-[[4-amino-6-(4-fluoroanilino)-1,3,5-triazin-2-yl]methylthio]-5-pyrimidinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency35.481310
1-(4-fluorophenyl)-7-(4-methylphenyl)-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dioneRattus norvegicus (Norway rat)Potency44.668410
1-[[3-(9-carbazolyl)-1-oxopropyl]amino]-3-(2-methylprop-2-enyl)thioureaRattus norvegicus (Norway rat)Potency25.118910
5-carbamoyl-4-methyl-2-[[(3-nitrophenyl)-oxomethyl]amino]-3-thiophenecarboxylic acid methyl esterRattus norvegicus (Norway rat)Potency56.234110
4-(1-benzotriazolyl)-3,5-dinitrobenzonitrileRattus norvegicus (Norway rat)Potency8.912510
3-(3-hydroxypropylamino)-7-methyl-1-(pentylamino)-6,8-dihydro-5H-2,7-naphthyridine-4-carbonitrileRattus norvegicus (Norway rat)Potency1.122010
2-[[(4-methyl-1-piperazinyl)-sulfanylidenemethyl]amino]benzene-1,4-dicarboxylic acid dimethyl esterRattus norvegicus (Norway rat)Potency15.848910
5-bromo-N-(2-fluorophenyl)-6-oxo-3-pyrancarboxamideRattus norvegicus (Norway rat)Potency19.952610
2-amino-1-[2-(4-morpholinyl)ethyl]-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency35.481310
N-bis(2-fluorophenoxy)phosphoryl-3,4-dimethylanilineRattus norvegicus (Norway rat)Potency28.183810
1-[2-(2-amino-3-cyano-1-pyrrolo[3,2-b]quinoxalinyl)ethyl]-3-phenylureaRattus norvegicus (Norway rat)Potency50.118710
4-[[(3,4-dimethoxyanilino)-oxomethyl]amino]benzoic acid butyl esterRattus norvegicus (Norway rat)Potency11.220210
N-[3-(benzenesulfonyl)-1-cyclohexyl-2-pyrrolo[3,2-b]quinoxalinyl]benzenesulfonamideRattus norvegicus (Norway rat)Potency39.810710
7-amino-9-(phenacylthio)-8-azaspiro[4.5]deca-6,9-diene-6,10-dicarbonitrileRattus norvegicus (Norway rat)Potency11.220210
N-[4-[[3-(4-sulfamoylanilino)-2-quinoxalinyl]sulfamoyl]phenyl]acetamideRattus norvegicus (Norway rat)Potency31.622810
3-cyclohexyl-10-methyl-2-thiophen-2-ylpyrimido[4,5-b]quinoline-4,5-dioneRattus norvegicus (Norway rat)Potency56.234110
N-(4,5-diphenyl-2-oxazolyl)-2-[(1-methyl-5-tetrazolyl)thio]acetamideRattus norvegicus (Norway rat)Potency10.000010
4-(2,5-dimethoxyphenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency14.125410
2-amino-N-(3-ethoxypropyl)-1-(4-sulfamoylphenyl)-3-pyrrolo[3,2-b]quinoxalinecarboxamideRattus norvegicus (Norway rat)Potency44.668410
4-(4-bromophenyl)sulfonyl-2-(2-furanyl)-5-(methylthio)oxazoleRattus norvegicus (Norway rat)Potency11.220210
3-acetyl-7-methoxycoumarinRattus norvegicus (Norway rat)Potency39.810710
4-(3,4-dimethoxyphenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl esterRattus norvegicus (Norway rat)Potency28.183810
2-[[(4-bromo-1-ethyl-3-pyrazolyl)-oxomethyl]amino]-4,5-dimethyl-3-thiophenecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency50.118710
2-(4-bromophenyl)-1-(2,4-dihydroxyphenyl)ethanoneRattus norvegicus (Norway rat)Potency50.118710
N-(9-ethyl-3-carbazolyl)-2-[5-(4-morpholinylsulfonyl)-2-thiophenyl]acetamideRattus norvegicus (Norway rat)Potency56.234110
1-[4-(benzenesulfonyl)-1-piperazinyl]-2-[(4-fluorophenyl)thio]ethanoneRattus norvegicus (Norway rat)Potency35.481310
1-[4-(4-chlorophenyl)sulfonyl-1-piperazinyl]-2-[(5,7-dimethyl-[1,2,4]triazolo[4,3-a]pyrimidin-3-yl)thio]ethanoneRattus norvegicus (Norway rat)Potency35.481310
4-[[4-(benzenesulfonyl)-1-piperazinyl]-oxomethyl]-2-methyl-1-phthalazinoneRattus norvegicus (Norway rat)Potency39.810710
1-[4-(benzenesulfonyl)-1-piperazinyl]-2-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]thio]ethanoneRattus norvegicus (Norway rat)Potency35.481310
3-[(4-acetyl-1-piperazinyl)sulfonyl]-N-(1H-benzimidazol-2-yl)benzamideRattus norvegicus (Norway rat)Potency35.481310
2-methyl-3-[oxo(thiophen-2-yl)methyl]-1-indolizinecarboxaldehydeRattus norvegicus (Norway rat)Potency50.118710
4,5-dimethoxy-2-[[(2-methoxyanilino)-oxomethyl]amino]benzoic acid methyl esterRattus norvegicus (Norway rat)Potency22.387210
3-methyl-6-thiophen-2-yl-4-isoxazolo[5,4-b]pyridinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency15.848910
N-[3-(6-methyl-4-phenyl-2-quinolinyl)phenyl]methanesulfonamideRattus norvegicus (Norway rat)Potency4.466810
2-[3-[(4-chlorophenyl)-oxomethyl]-6-methoxy-4-oxo-1-quinolinyl]-N-(4-fluorophenyl)acetamideRattus norvegicus (Norway rat)Potency8.912510
6-propan-2-yl-2-sulfanylidene-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-oneRattus norvegicus (Norway rat)Potency11.220210
4-(dipropylsulfamoyl)-N-[5-[(methylthio)methyl]-1,3,4-oxadiazol-2-yl]benzamideRattus norvegicus (Norway rat)Potency2.511910
2-[2-furanyl(oxo)methyl]imino-5-oxo-1-propan-2-yl-3-dipyrido[1,2-d-3',4'-f]pyrimidinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency44.668410
1-[4-(benzenesulfonyl)-1-piperazinyl]-2-[(4-methyl-2-thiazolyl)thio]ethanoneRattus norvegicus (Norway rat)Potency56.234110
1-[4-(benzenesulfonyl)-1-piperazinyl]-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)thio]ethanoneRattus norvegicus (Norway rat)Potency50.118710
1-[2,3-bis(2-pyridinyl)-6-quinoxalinyl]-3-propylthioureaRattus norvegicus (Norway rat)Potency0.177810
1-(2,3-dimethyl-6-quinoxalinyl)-3-(3-hydroxypropyl)thioureaRattus norvegicus (Norway rat)Potency1.584910
N-[2-(1-naphthalenyl)-1,3-benzoxazol-5-yl]-1H-1,2,4-triazole-5-carboxamideRattus norvegicus (Norway rat)Potency39.810710
4-methyl-N-[2-(phenylmethyl)-3,4-dihydro-1H-pyrazino[1,2-a]benzimidazol-8-yl]benzenesulfonamideRattus norvegicus (Norway rat)Potency11.220210
2,3-bis(2-furanyl)-N-[4-(4-morpholinyl)phenyl]-6-quinoxalinecarboxamideRattus norvegicus (Norway rat)Potency1.000010
2-butoxy-7-hydroxy-9-fluorenoneRattus norvegicus (Norway rat)Potency28.183810
N-[2-(cyclohexylthio)ethyl]-4-methyl-3-[(4-methylphenyl)sulfamoyl]benzamideRattus norvegicus (Norway rat)Potency50.118710
3-[1-(3-methoxypropyl)-5-thiophen-2-yl-2-pyrrolyl]propanoic acidRattus norvegicus (Norway rat)Potency35.481310
2-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-N-(3-methoxyphenyl)benzamideRattus norvegicus (Norway rat)Potency7.943310
acetic acid [4-[(1-oxo-2-phenylethyl)amino]phenyl] esterRattus norvegicus (Norway rat)Potency11.220210
4-(3-hydroxyphenyl)-1-(thiophen-2-ylmethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl esterRattus norvegicus (Norway rat)Potency39.810710
1-(3-fluorophenyl)-4-(4-hydroxy-3-methoxy-5-nitrophenyl)-4H-pyridine-3,5-dicarboxylic acid diethyl esterRattus norvegicus (Norway rat)Potency12.589310
N-(2-fluorophenyl)-4-methoxy-2,5-dimethylbenzenesulfonamideRattus norvegicus (Norway rat)Potency56.234110
1-[4-(5-fluoro-1,2-benzoxazol-3-yl)-1-piperidinyl]-2-[(4-methyl-2-quinolinyl)thio]ethanoneRattus norvegicus (Norway rat)Potency11.220210
1,4-dioxa-8-azaspiro[4.5]decan-8-yl-(5,7-diphenyl-2-pyrazolo[1,5-a]pyrimidinyl)methanoneRattus norvegicus (Norway rat)Potency17.782810
N-[(phenacylamino)-sulfanylidenemethyl]cyclohexanecarboxamideRattus norvegicus (Norway rat)Potency10.000010
N-(3-dibenzofuranyl)-2-[2-oxo-2-(2,4,6-trimethylanilino)ethoxy]benzamideRattus norvegicus (Norway rat)Potency28.183810
3-methoxy-2-naphthalenecarboxylic acid [2-(4-morpholinyl)-2-oxoethyl] esterRattus norvegicus (Norway rat)Potency28.183810
2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]thio]-N-[4-(4-morpholinylsulfonyl)phenyl]acetamideRattus norvegicus (Norway rat)Potency44.668410
3-oxo-2,4-dihydroquinoxaline-1-carboxylic acid (phenylmethyl) esterRattus norvegicus (Norway rat)Potency3.981110
5-[(2-hydroxy-5-methylphenyl)-oxomethyl]-N,1-bis[2-(4-methoxyphenyl)ethyl]-2-oxo-3-pyridinecarboxamideRattus norvegicus (Norway rat)Potency39.810710
1-(2-methoxyethyl)-7-thiophen-2-yl-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine-2,4-dioneRattus norvegicus (Norway rat)Potency28.183810
1-butyl-2,4-dioxo-7-thiophen-2-yl-5-pyrido[2,3-d]pyrimidinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency35.481310
2-(2-furanylmethylamino)benzoic acid [2-oxo-2-(3-oxo-2,4-dihydroquinoxalin-1-yl)ethyl] esterRattus norvegicus (Norway rat)Potency14.125410
2-[[[[(4-fluorophenyl)-oxomethyl]amino]-sulfanylidenemethyl]amino]-4-(5-methyl-2-furanyl)-3-thiophenecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency28.183810
2-(2-methyl-1-benzimidazolyl)acetic acid [2-(2-methyl-1H-indol-3-yl)-2-oxoethyl] esterRattus norvegicus (Norway rat)Potency50.118710
2,5-dimethyl-1-(3-methylphenyl)-N-(4-methylphenyl)-3-pyrrolecarboxamideRattus norvegicus (Norway rat)Potency56.234110
N-(6-methoxy-1,3-benzothiazol-2-yl)-3-(4-morpholinylsulfonyl)benzamideRattus norvegicus (Norway rat)Potency1.412510
4-chloro-3-(1-pyrrolidinylsulfonyl)benzoic acid [2-(butylamino)-2-oxoethyl] esterRattus norvegicus (Norway rat)Potency50.118710
3-(methylsulfamoyl)benzoic acid [2-[(9-ethyl-3-carbazolyl)amino]-2-oxoethyl] esterRattus norvegicus (Norway rat)Potency56.234110
1-(4-ethylphenyl)-3-[1-(phenylmethyl)-4-piperidinyl]thioureaRattus norvegicus (Norway rat)Potency50.118710
2-[(3-pyridinylamino)methylidene]propanedinitrileRattus norvegicus (Norway rat)Potency56.234110
4-[[2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]thio]-1-oxoethyl]amino]benzoic acidRattus norvegicus (Norway rat)Potency56.234110
2-[[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]thio]-3-ethyl-5,6-dimethyl-4-thieno[2,3-d]pyrimidinoneRattus norvegicus (Norway rat)Potency50.118710
2-(butylamino)benzoic acid [2-oxo-2-(4-sulfamoylanilino)ethyl] esterRattus norvegicus (Norway rat)Potency31.622810
[1-(4-fluorophenyl)sulfonyl-4-piperidinyl]-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methanoneRattus norvegicus (Norway rat)Potency56.234110
N-[(1S)-1-(1H-benzimidazol-2-yl)-2-methylpropyl]-3-(1-pyrrolidinylsulfonyl)benzamideRattus norvegicus (Norway rat)Potency50.118710
5-(3,4-dimethoxyphenyl)-2-(1-piperidinyl)-7-thiazolo[4,5-b]pyridinecarboxylic acidRattus norvegicus (Norway rat)Potency31.622810
1-[4-(benzenesulfonyl)-1-piperazinyl]-2-[4-(1,3,4-oxadiazol-2-yl)phenoxy]ethanoneRattus norvegicus (Norway rat)Potency39.810710
N-[3-(4-morpholinyl)propyl]-3-(3-pyridinyl)-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amineRattus norvegicus (Norway rat)Potency50.118710
3-[ethyl(phenyl)sulfamoyl]-4-methylbenzoic acid (4-methyl-2-oxo-1-benzopyran-7-yl) esterRattus norvegicus (Norway rat)Potency28.183810
2-oxo-6-phenyl-4-(trifluoromethyl)-1H-pyridine-3-carbonitrileRattus norvegicus (Norway rat)Potency35.481310
2-(methylamino)-6-thiophen-2-yl-4-(trifluoromethyl)-3-pyridinecarbonitrileRattus norvegicus (Norway rat)Potency28.183810
3-(4-chlorophenyl)-2-methyl-3,3a,4,5-tetrahydrobenzo[g]indazoleRattus norvegicus (Norway rat)Potency11.220210
8-fluoro-4H-thieno[3,2-c][1]benzopyran-2-carboxylic acid methyl esterRattus norvegicus (Norway rat)Potency25.118910
N-tert-butyl-4-[3-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamideRattus norvegicus (Norway rat)Potency3.548110
4-(benzenesulfonyl)-1-[(4-chlorophenyl)methyl]-4-piperidinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency28.183810
1-[(3-chlorophenyl)methyl]-3-[5-(methylthio)-1,3,4-oxadiazol-2-yl]-2-pyridinoneRattus norvegicus (Norway rat)Potency28.183810
4-chlorobenzoic acid [3-cyano-6-(3-methoxyphenyl)-2-pyridinyl] esterRattus norvegicus (Norway rat)Potency35.481310
2-chloro-N-[3-cyano-4-[(4-methoxyphenyl)thio]phenyl]benzamideRattus norvegicus (Norway rat)Potency1.258910
8-methoxy-4-oxo-1H-quinoline-2-carboxylic acid methyl esterRattus norvegicus (Norway rat)Potency35.481310
2-[4-(trifluoromethoxy)phenyl]imidazo[1,2-a]pyrimidineRattus norvegicus (Norway rat)Potency35.481310
3-(4-ethyl-1-piperazinyl)-5-methylpyridazino[3,4-b][1,4]benzoxazineRattus norvegicus (Norway rat)Potency25.118910
3-methyl-2-[(4-methylphenyl)sulfonylamino]pentanoic acid (4-oxo-2,3-dihydro-1H-cyclopenta[c][1]benzopyran-7-yl) esterRattus norvegicus (Norway rat)Potency31.622810
4-methyl-2-[(4-methylphenyl)sulfonylamino]pentanoic acid (4-oxo-2,3-dihydro-1H-cyclopenta[c][1]benzopyran-7-yl) esterRattus norvegicus (Norway rat)Potency35.481310
N-(3-acetyl-2-methyl-5-benzofuranyl)-N-(4-chloro-3-nitrophenyl)sulfonylacetamideRattus norvegicus (Norway rat)Potency39.810710
LSM-19241Rattus norvegicus (Norway rat)Potency35.481310
N-[(2-hydroxy-1-naphthalenyl)-(4-methoxyphenyl)methyl]-2-methylpropanamideRattus norvegicus (Norway rat)Potency35.481310
N-[(2-chlorophenyl)-(2-hydroxy-1-naphthalenyl)methyl]butanamideRattus norvegicus (Norway rat)Potency44.668410
4-(1,4-dioxaspiro[4.11]hexadecan-3-ylmethyl)morpholineRattus norvegicus (Norway rat)Potency11.220210
6-amino-4-(2-methylpropyl)-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrileRattus norvegicus (Norway rat)Potency35.481310
LSM-19663Rattus norvegicus (Norway rat)Potency25.118910
6-methyl-2-[4-(1-piperidinylsulfonyl)phenyl]imidazo[1,2-a]pyridineRattus norvegicus (Norway rat)Potency6.309610
4-(3-hydroxyphenyl)-1-(2-oxolanylmethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl esterRattus norvegicus (Norway rat)Potency35.481310
4-[[1-[(3,4-dichlorophenyl)methyl]-3-indolyl]-(3-methyl-5-oxo-1,2-dihydropyrazol-4-yl)methyl]-5-methyl-1,2-dihydropyrazol-3-oneRattus norvegicus (Norway rat)Potency3.548110
N-[2,6-dimethyl-3-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-N,4-dimethylbenzenesulfonamideRattus norvegicus (Norway rat)Potency11.220210
5-(2-oxolanylmethylamino)-2-thiophen-2-yl-4-oxazolecarbonitrileRattus norvegicus (Norway rat)Potency50.118710
2-methyl-3-[(2-methyl-1H-indol-3-yl)-(2-pyridinyl)methyl]-1H-indoleRattus norvegicus (Norway rat)Potency10.000010
1-(2,4-dimethoxyphenyl)-3-[4-(4-morpholinyl)anilino]pyrrolidine-2,5-dioneRattus norvegicus (Norway rat)Potency56.234110
importazoleRattus norvegicus (Norway rat)Potency28.183810
4-[[2-(4-ethyl-3-oxo-2-morpholinyl)-1-oxoethyl]amino]benzoic acid ethyl esterRattus norvegicus (Norway rat)Potency1.258910
3-[2-(2,4-dimethyl-3-furanyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-2-indoloneRattus norvegicus (Norway rat)Potency28.183810
N-[3-chloro-4-[4-[oxo-(4-propoxyphenyl)methyl]-1-piperazinyl]phenyl]propanamideRattus norvegicus (Norway rat)Potency1.584910
N-(4,5-dihydrothiazol-2-yl)-3,5-dimethyl-1-adamantanecarboxamideRattus norvegicus (Norway rat)Potency31.622810
2-(1,3-benzothiazol-2-ylamino)-5-spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclopentane]oneRattus norvegicus (Norway rat)Potency39.810710
N-[5-(2-oxolanyl)-1,3,4-thiadiazol-2-yl]-2-thiophenecarboxamideRattus norvegicus (Norway rat)Potency7.079510
N-[2-(1-azepanyl)-2-oxoethyl]-N-[(4-chlorophenyl)methyl]methanesulfonamideRattus norvegicus (Norway rat)Potency50.118710
N-(2-methoxy-3-dibenzofuranyl)-2-oxolanecarboxamideRattus norvegicus (Norway rat)Potency39.810710
3-[5-(4-methylphenyl)-1-(2-oxolanylmethyl)-2-pyrrolyl]propanoic acidRattus norvegicus (Norway rat)Potency31.622810
3-[5-(4-methoxyphenyl)-1-(2-oxolanylmethyl)-2-pyrrolyl]propanoic acidRattus norvegicus (Norway rat)Potency28.183810
2-[3-oxo-1-[[[oxo(thiophen-2-yl)methyl]amino]-sulfanylidenemethyl]-2-piperazinyl]acetic acid propan-2-yl esterRattus norvegicus (Norway rat)Potency0.177810
2-methyl-1-cyclopropanecarboxylic acid (7-bromo-4-oxo-2-pyrido[1,2-a]pyrimidinyl)methyl esterRattus norvegicus (Norway rat)Potency11.220210
4-[5-(4-morpholinylsulfonyl)-2-thiophenyl]-3-phenyl-2H-furan-5-oneRattus norvegicus (Norway rat)Potency50.118710
1-[2,5-dimethyl-1-(2-oxolanylmethyl)-3-pyrrolyl]-2-[(5-phenyl-4-prop-2-enyl-1,2,4-triazol-3-yl)thio]ethanoneRattus norvegicus (Norway rat)Potency56.234110
1-adamantanecarboxylic acid [2-(2-furanylmethylamino)-2-oxoethyl] esterRattus norvegicus (Norway rat)Potency56.234110
2,3-dihydro-1,4-benzodioxin-3-yl-[4-(3,4-dimethylphenyl)sulfonyl-1-piperazinyl]methanoneRattus norvegicus (Norway rat)Potency39.810710
5-amino-3-[[[1-(2-furanylmethyl)-5-oxo-3-pyrrolidinyl]-oxomethoxy]methyl]thiophene-2,4-dicarboxylic acid dimethyl esterRattus norvegicus (Norway rat)Potency8.912510
2-(4-chloro-2-methylphenoxy)-N-[2-(4-morpholinyl)phenyl]propanamideRattus norvegicus (Norway rat)Potency56.234110
2-(2-furanyl)-N-(2-oxolanylmethyl)-4-quinolinecarboxamideRattus norvegicus (Norway rat)Potency50.118710
3-(4-methylphenyl)sulfonyl-1-(3-oxolanylmethyl)-2-pyrrolo[3,2-b]quinoxalinamineRattus norvegicus (Norway rat)Potency35.481310
5-[[[5-(2,3-dihydro-1,4-benzodioxin-3-yl)-4-methyl-1,2,4-triazol-3-yl]thio]methyl]-2-phenylthiazoleRattus norvegicus (Norway rat)Potency39.810710
9-(n-butyl)-6-thioguanineRattus norvegicus (Norway rat)Potency0.100010
N-[(2-hydroxy-1-naphthalenyl)-(4-methylphenyl)methyl]cyclohexanecarboxamideRattus norvegicus (Norway rat)Potency50.118710
yl-109Rattus norvegicus (Norway rat)Potency25.118910
6-(2-furanyl)-4-[4-(methanesulfonamido)phenyl]-2-oxo-1-cyclohex-3-enecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency56.234110
N-cyclopentyl-2-[[2-[5-(4-fluorophenyl)-2-tetrazolyl]-1-oxoethyl]-(2-furanylmethyl)amino]hexanamideRattus norvegicus (Norway rat)Potency56.234110
N-tert-butyl-2-(N-[2-[5-(4-fluorophenyl)-2-tetrazolyl]-1-oxoethyl]-3-hydroxyanilino)-2-(1H-indol-3-yl)acetamideRattus norvegicus (Norway rat)Potency44.668410
N-cyclohexyl-2-(4-fluoro-N-[1-oxo-2-(3-thiophenyl)ethyl]anilino)-2-(4-fluorophenyl)acetamideRattus norvegicus (Norway rat)Potency28.183810
1-(9-cyclopentyl-9-azabicyclo[3.3.1]nonan-3-yl)-3-(3,5-dimethylphenyl)thioureaRattus norvegicus (Norway rat)Potency35.481310
1-[3-[(7-cyano-[1,3]dioxolo[4,5-g]quinolin-6-yl)amino]propyl]-3-(3-methoxypropyl)thioureaRattus norvegicus (Norway rat)Potency17.782810
1-[3-[(7-cyano-[1,3]dioxolo[4,5-g]quinolin-6-yl)amino]propyl]-3-(3-ethoxypropyl)thioureaRattus norvegicus (Norway rat)Potency25.118910
N-[2-(cyclopentylamino)-2-oxoethyl]-4,7-dimethyl-N-(2-methylphenyl)-2-oxo-3H-pyrido[1,2-a]pyrimidine-4-carboxamideRattus norvegicus (Norway rat)Potency35.481310
[4-[5-tert-butyl-3-(phenylmethyl)-7-triazolo[4,5-d]pyrimidinyl]-1-piperazinyl]-(2-furanyl)methanoneRattus norvegicus (Norway rat)Potency5.011910
1-(1-tert-butyl-5-tetrazolyl)-N-[(4-fluorophenyl)methyl]-N-(2-furanylmethyl)-1-[4-(trifluoromethyl)phenyl]methanamineRattus norvegicus (Norway rat)Potency7.079510
N-[2-(1-cyclohexenyl)ethyl]-3-(1,3-dioxo-2-isoindolyl)propanamideRattus norvegicus (Norway rat)Potency0.177810
3-[[2-(4-fluorophenoxy)-1-oxoethyl]amino]-2-benzofurancarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency35.481310
N-(2,4-dimethoxyphenyl)-3-[[2-furanyl(oxo)methyl]amino]-2-benzofurancarboxamideRattus norvegicus (Norway rat)Potency39.810710
7-(4-methoxyphenyl)-5-methyl-2-(methylthio)-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidineRattus norvegicus (Norway rat)Potency19.952610
N-(3-chlorophenyl)-2-[6,7-dimethoxy-2,4-dioxo-3-(2-oxolanylmethyl)-1-quinazolinyl]acetamideRattus norvegicus (Norway rat)Potency1.778310
2-phenyl-5-(1-piperidinyl)-4-triazolecarbonitrileRattus norvegicus (Norway rat)Potency31.622810
1-(4-methyl-2-prop-2-enylphenoxy)-3-(4-phenyl-1-piperazinyl)-2-propanolRattus norvegicus (Norway rat)Potency15.848910
2-[(3-oxo-2-propan-2-yl-2H-imidazo[1,2-c]quinazolin-5-yl)thio]-N-[2-(4-sulfamoylphenyl)ethyl]acetamideRattus norvegicus (Norway rat)Potency35.481310
N-[[1-(4-methoxyphenyl)-3-pyrrolidinyl]methyl]-3-(trifluoromethyl)benzenesulfonamideRattus norvegicus (Norway rat)Potency5.623410
N-(2-methyl-4-oxo-1-propyl-6-quinolinyl)-2-pyrazinecarboxamideRattus norvegicus (Norway rat)Potency3.548110
1,7,7-trimethyl-9-oxo-N-(2-oxolanylmethyl)-8H-furo[3,2-f][1]benzopyran-2-carboxamideRattus norvegicus (Norway rat)Potency56.234110
5a,6,7,8,9,10-hexahydro-5H-azepino[2,1-b]quinazolin-12-oneRattus norvegicus (Norway rat)Potency28.183810
3,5-dimethyl-N-(2-phenylethyl)-N-(phenylmethyl)-4-isoxazolesulfonamideRattus norvegicus (Norway rat)Potency50.118710
2-cyclopentyl-4-[1,4-dioxa-8-azaspiro[4.5]decan-8-yl(oxo)methyl]-9-methyl-1-pyrido[3,4-b]indoloneRattus norvegicus (Norway rat)Potency35.481310
3-[[2-furanyl(oxo)methyl]amino]-N-(4-methoxyphenyl)-2-benzofurancarboxamideRattus norvegicus (Norway rat)Potency7.943310
[1-(2,1,3-benzothiadiazol-4-ylsulfonyl)-3-piperidinyl]-(2-methyl-2,3-dihydroindol-1-yl)methanoneRattus norvegicus (Norway rat)Potency6.309610
2-(4-ethoxyphenyl)-5-[1-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-piperidinyl]-6-pyrazolo[1,5-a]pyrimidinecarboxylic acidRattus norvegicus (Norway rat)Potency2.238710
1-[[5-bromo-1-[cyclopropyl(oxo)methyl]-2,3-dihydroindol-7-yl]sulfonyl]-4-piperidinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency14.125410
N-[3-(3,4-dihydro-1H-isoquinolin-2-yl)propyl]-2-(3-oxo-1,4-benzoxazin-4-yl)acetamideRattus norvegicus (Norway rat)Potency1.258910
2,4-dioxo-3-(2-oxolanylmethyl)-N-pentyl-1H-quinazoline-7-carboxamideRattus norvegicus (Norway rat)Potency39.810710
2-(2-methoxyethyl)-9-methyl-4-[(4-methyl-1-piperidinyl)-oxomethyl]-1-pyrido[3,4-b]indoloneRattus norvegicus (Norway rat)Potency35.481310
2-amino-4-[5-methyl-2-(methylthio)-3-thiophenyl]-5-oxo-1-(3-pyridinyl)-4,6,7,8-tetrahydroquinoline-3-carbonitrileRattus norvegicus (Norway rat)Potency11.220210
3-[[oxo-[3-(1-piperidinylsulfonyl)phenyl]methyl]amino]benzoic acidRattus norvegicus (Norway rat)Potency11.220210
6-(1-azepanylsulfonyl)-1-ethyl-N-(2-furanylmethyl)-4-oxo-3-quinolinecarboxamideRattus norvegicus (Norway rat)Potency28.183810
3-(2-chlorophenyl)-5-methyl-N-[3-(3-methyl-2-imidazo[1,2-a]pyrimidinyl)phenyl]-4-isoxazolecarboxamideRattus norvegicus (Norway rat)Potency35.481310
5-(1-azepanyl)-1,3,4-thiadiazol-2-amineRattus norvegicus (Norway rat)Potency5.623410
LSM-16579Rattus norvegicus (Norway rat)Potency50.118710
2-chloro-6-[4-morpholinyl(oxo)methyl]-11-pyrido[2,1-b]quinazolinoneRattus norvegicus (Norway rat)Potency31.622810
4-[[9-methyl-2-(2-methylpropyl)-1-oxo-4-pyrido[3,4-b]indolyl]-oxomethyl]-1-piperazinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency25.118910
[4-(2-pyrimidinyl)-1-piperazinyl]-[1-[4-(2-pyrimidinyl)-1-piperazinyl]-4-isoquinolinyl]methanoneRattus norvegicus (Norway rat)Potency50.118710
2,5-dimethyl-4-(4-methyl-1-piperidinyl)-6-thieno[2,3-d]pyrimidinecarboxylic acidRattus norvegicus (Norway rat)Potency1.412510
3-(5-chloro-2-methylphenyl)-6-(2,6-dimethyl-4-morpholinyl)-1H-pyrimidine-2,4-dioneRattus norvegicus (Norway rat)Potency11.220210
N-(2-furanylmethyl)-N'-[4-methyl-2-(4-methyl-1-piperazinyl)-6-quinolinyl]butanediamideRattus norvegicus (Norway rat)Potency50.118710
3-(4-chlorophenyl)-2-(1-pyrrolidinyl)-4-quinazolinoneRattus norvegicus (Norway rat)Potency50.118710
N-ethyl-N-(2-ethylphenyl)-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamideRattus norvegicus (Norway rat)Potency50.118710
1-methyl-N-(2-methylcyclohexyl)-4-oxo-6-(1-pyrrolidinylsulfonyl)-3-quinolinecarboxamideRattus norvegicus (Norway rat)Potency31.622810
N-(2-furanylmethyl)-1-[2-(2-hydroxyethoxy)ethyl]-2-imino-10-methyl-5-oxo-3-dipyrido[3,4-c-1',2'-f]pyrimidinecarboxamideRattus norvegicus (Norway rat)Potency35.481310
6-methoxy-N-(thiophen-2-ylmethyl)-2-furo[2,3-b]quinolinecarboxamideRattus norvegicus (Norway rat)Potency31.622810
N-[5-(diethylsulfamoyl)-2-(4-morpholinyl)phenyl]-2-oxo-1H-quinoline-4-carboxamideRattus norvegicus (Norway rat)Potency56.234110
4-[[(3,4-dimethoxyphenyl)methyl-[(4-methylanilino)-sulfanylidenemethyl]amino]methyl]benzoic acidRattus norvegicus (Norway rat)Potency31.622810
2-[[2-(4-methoxyphenyl)-6-methyl-1-benzopyran-4-ylidene]amino]-4-methylpentanoic acidRattus norvegicus (Norway rat)Potency28.183810
7-methoxy-2-(3-methoxyanilino)-3-quinolinecarbonitrileRattus norvegicus (Norway rat)Potency35.481310
N-(3-carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-methyl-3-pyrazolecarboxamideRattus norvegicus (Norway rat)Potency44.668410
2-benzoylimino-1-(2-furanylmethyl)-10-methyl-5-oxo-3-dipyrido[3,4-c-1',2'-f]pyrimidinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency14.125410
2-amino-4-(2-ethoxyphenyl)-6,7-dimethyl-5-oxo-4H-pyrano[3,2-c]pyridine-3-carbonitrileRattus norvegicus (Norway rat)Potency11.220210
7-(5-bromo-2-fluorophenyl)-5-(4-bromophenyl)-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidineRattus norvegicus (Norway rat)Potency11.220210
6-[2-(1-azepanyl)-2-oxoethoxy]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-oneRattus norvegicus (Norway rat)Potency35.481310
2-thiophen-2-yl-4-quinolinecarboxylic acid (2-oxo-3-oxolanyl) esterRattus norvegicus (Norway rat)Potency35.481310
2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-5-methyl-4-(4-methylphenyl)-1,2,4-triazol-3-oneRattus norvegicus (Norway rat)Potency19.952610
5-(4-ethoxyphenyl)-1,3-diphenyl-3a,6a-dihydropyrrolo[3,4-c]pyrazole-4,6-dioneRattus norvegicus (Norway rat)Potency35.481310
3-[5-(dimethylsulfamoyl)-1-ethyl-2-benzimidazolyl]propanoic acidRattus norvegicus (Norway rat)Potency50.118710
1-[(4-chlorophenyl)methyl]-3-(3-fluorophenyl)-1-(3,3,3-trifluoro-2-hydroxypropyl)ureaRattus norvegicus (Norway rat)Potency35.481310
5-[(4-chlorophenyl)-oxomethyl]-4-hydroxy-6-[5-(2-nitrophenyl)-2-furanyl]-4-(trifluoromethyl)-1,3-diazinan-2-oneRattus norvegicus (Norway rat)Potency50.118710
3-(3-bromoanilino)-2-oxo-1H-indole-3-carbonitrileRattus norvegicus (Norway rat)Potency6.309610
2-(4-nitrophenyl)-4-thiazolecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency6.309610
LSM-24581Rattus norvegicus (Norway rat)Potency35.481310
2-amino-4-(2-fluorophenyl)-6-(3-pyridinyl)-3-pyridinecarbonitrileRattus norvegicus (Norway rat)Potency35.481310
4-(2-methylphenoxy)-6-phenylfuro[2,3-d]pyrimidineRattus norvegicus (Norway rat)Potency50.118710
1-(4-chlorophenyl)-3-[2-(2-furanylmethyl)cyclohexyl]ureaRattus norvegicus (Norway rat)Potency11.220210
3-(2-methoxyphenyl)-2-methyl-4-oxo-1H-quinazoline-2-carboxylic acid methyl esterRattus norvegicus (Norway rat)Potency35.481310
N-[4-[cyano-[3-[2-(4-morpholinyl)ethylamino]-2-quinoxalinyl]methyl]sulfonylphenyl]acetamideRattus norvegicus (Norway rat)Potency28.183810
N-(3,5-dichloro-2-pyridinyl)-2-[[1-(2-methoxyethyl)-2-benzimidazolyl]thio]propanamideRattus norvegicus (Norway rat)Potency56.234110
4-[(3-methyl-5-nitro-4-imidazolyl)amino]phenolRattus norvegicus (Norway rat)Potency17.782810
N-[4-[cyano-[3-(3-hydroxypropylamino)-2-quinoxalinyl]methyl]sulfonylphenyl]acetamideRattus norvegicus (Norway rat)Potency31.622810
2-hydroxybenzoic acid [2-(2-ethoxyanilino)-2-oxo-1-phenylethyl] esterRattus norvegicus (Norway rat)Potency22.387210
vu0155094Rattus norvegicus (Norway rat)Potency35.481310
1-[2-(4-methoxyphenyl)-4-[oxo(1-pyrrolidinyl)methyl]-3-thiazolidinyl]-1-propanoneRattus norvegicus (Norway rat)Potency56.234110
3-(2-chlorophenyl)-N-[5-(2,4-dichlorophenyl)-1,3,4-thiadiazol-2-yl]-5-methyl-4-isoxazolecarboxamideRattus norvegicus (Norway rat)Potency50.118710
N-[4-(phenoxymethyl)-2-thiazolyl]-1-adamantanecarboxamideRattus norvegicus (Norway rat)Potency56.234110
4-[4-diethoxyphosphoryl-2-(1-naphthalenyl)-5-oxazolyl]morpholineRattus norvegicus (Norway rat)Potency39.810710
N-[3-[3-(1-piperidinylsulfonyl)anilino]-2-quinoxalinyl]benzenesulfonamideRattus norvegicus (Norway rat)Potency56.234110
4-(1-phenylethyl)-3-(5-propyl-3-thiophenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency1.584910
N-(1,3-diphenylpropan-2-ylideneamino)-2-hydroxybenzamideRattus norvegicus (Norway rat)Potency56.234110
2-[(3-fluorophenyl)-(2-pyridinylamino)methyl]-3-hydroxy-6-(hydroxymethyl)-4-pyranoneRattus norvegicus (Norway rat)Potency12.589310
[3,5-bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(4-propan-2-ylphenyl)-4-quinolinyl]methanoneRattus norvegicus (Norway rat)Potency1.412510
7-methoxy-N-(3-pyridinylmethyl)-2-furo[2,3-b]quinolinecarboxamideRattus norvegicus (Norway rat)Potency31.622810
N-[4-(1H-benzimidazol-2-yl)phenyl]-3-(2,5-dioxo-1-pyrrolidinyl)benzamideRattus norvegicus (Norway rat)Potency35.481310
N-[2-(3-methoxyanilino)-2-oxoethyl]-4-methylbenzamideRattus norvegicus (Norway rat)Potency50.118710
1H-indazole-3-carboxylic acid [2-(4-nitroanilino)-2-oxoethyl] esterRattus norvegicus (Norway rat)Potency12.589310
2-[[2-(2-amino-4-oxo-5-thiazolyl)-1-oxoethyl]amino]-6-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid methyl esterRattus norvegicus (Norway rat)Potency22.387210
N2-(2-furanylmethyl)-5-nitro-6-(1-pyrrolidinyl)pyrimidine-2,4-diamineRattus norvegicus (Norway rat)Potency3.548110
5-(4-morpholinylsulfonyl)-2-(1-piperidinyl)benzoic acid [2-[[(3-methylbutylamino)-oxomethyl]amino]-2-oxoethyl] esterRattus norvegicus (Norway rat)Potency50.118710
2-[(2-nitro-3-pyridinyl)oxy]-N-[2-(phenylthio)phenyl]acetamideRattus norvegicus (Norway rat)Potency3.548110
LSM-27960Rattus norvegicus (Norway rat)Potency12.589310
N2,N6-bis[4-(dimethylamino)phenyl]pyridine-2,6-dicarboxamideRattus norvegicus (Norway rat)Potency1.995310
LSM-16446Rattus norvegicus (Norway rat)Potency31.622810
N-[3-[(2-bromo-5-methylphenyl)sulfamoyl]-4-methoxyphenyl]-4-fluorobenzamideRattus norvegicus (Norway rat)Potency4.466810
LSM-33280Rattus norvegicus (Norway rat)Potency6.309610
3-(benzenesulfonyl)-1-cyclopropyl-2-pyrrolo[3,2-b]quinoxalinamineRattus norvegicus (Norway rat)Potency28.183810
2-[[(3,5-dimethylphenyl)-oxomethyl]amino]acetic acid [2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]-2-oxoethyl] esterRattus norvegicus (Norway rat)Potency28.183810
2-(3-methoxyphenyl)-3,5,6,7,8,9-hexahydrocyclohepta[2,3]thieno[2,4-b]pyrimidin-4-oneRattus norvegicus (Norway rat)Potency7.943310
2-(4-bromophenyl)-4-quinolinecarboxylic acid (2-oxo-3-oxolanyl) esterRattus norvegicus (Norway rat)Potency56.234110
2-(2-furanyl)-4-mercapto-3-(4-methylphenyl)-6-oxo-1,2-dihydropyrimidine-5-carbonitrileRattus norvegicus (Norway rat)Potency50.118710
4-dimethoxyphosphoryl-2-(1-naphthalenyl)-N-(phenylmethyl)-5-oxazolamineRattus norvegicus (Norway rat)Potency35.481310
LSM-28572Rattus norvegicus (Norway rat)Potency35.481310
2-chloro-1-[1-(3-isoxazolyl)-2,5-dimethyl-3-pyrrolyl]ethanoneRattus norvegicus (Norway rat)Potency50.118710
2,5-dimethyl-3-furancarboxylic acid [2-(2-ethoxyanilino)-2-oxo-1-phenylethyl] esterRattus norvegicus (Norway rat)Potency11.220210
N-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]-5-methyl-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamideRattus norvegicus (Norway rat)Potency3.981110
N-(4,5-dithiophen-2-yl-2-thiazolyl)-2-methyl-1-cyclopropanecarboxamideRattus norvegicus (Norway rat)Potency0.707910
2-[[4-(3,4-dimethylphenyl)-1-phenyl-2-imidazolyl]thio]-N-(1,1-dioxo-3-thiolanyl)acetamideRattus norvegicus (Norway rat)Potency50.118710
1-(4-bromophenyl)-1'-methyl-6'-nitro-2'-phenylspiro[1,3-diazinane-5,3'-2,4-dihydroquinoline]-2,4,6-trioneRattus norvegicus (Norway rat)Potency39.810710
8-[[4-[2-furanyl(oxo)methyl]-1-piperazinyl]methyl]-1,3-dimethyl-7-[(2-methylphenyl)methyl]purine-2,6-dioneRattus norvegicus (Norway rat)Potency50.118710
3-(3,4-dimethoxyphenyl)-2,5-dimethyl-7-[4-(phenylmethyl)-1-piperazinyl]pyrazolo[1,5-a]pyrimidineRattus norvegicus (Norway rat)Potency5.623410
5-(4-methylphenyl)-2-(1-piperidinyl)-7-thiazolo[4,5-b]pyridinecarboxylic acidRattus norvegicus (Norway rat)Potency28.183810
1-[3-(dimethylamino)propyl]-1-(phenylmethyl)-3-[3-(trifluoromethyl)phenyl]thioureaRattus norvegicus (Norway rat)Potency11.220210
N-[(4-chlorophenyl)methyl]-2-[[[(2-fluorophenyl)methyl-(phenylmethyl)amino]-sulfanylidenemethyl]amino]acetamideRattus norvegicus (Norway rat)Potency14.125410
5-methyl-2-phenyl-4-propan-2-ylidene-3-pyrazoloneRattus norvegicus (Norway rat)Potency4.466810
diclofenac sodiumRattus norvegicus (Norway rat)Potency56.234110
N-(3-oxo-2-benzo[f][1]benzopyranyl)acetamideRattus norvegicus (Norway rat)Potency25.118910
4-[1-(2,4-dichlorophenyl)-2-nitroethyl]-5-(2-hydroxyphenyl)-1,2-dihydropyrazol-3-oneRattus norvegicus (Norway rat)Potency14.125410
4-[2-[[2-[(5-methyl-1H-pyrazol-3-yl)amino]-2-oxoethyl]thio]-4-oxo-3-quinazolinyl]-N-(phenylmethyl)butanamideRattus norvegicus (Norway rat)Potency50.118710
4-tert-butyl-N-[3-[4-[3-[[(4-tert-butylphenyl)-oxomethyl]amino]propyl]-1-piperazinyl]propyl]benzamideRattus norvegicus (Norway rat)Potency25.118910
methysergide maleateRattus norvegicus (Norway rat)Potency50.118710
esculetinRattus norvegicus (Norway rat)Potency35.481310
zearalenoneRattus norvegicus (Norway rat)Potency50.118710
coumestrolRattus norvegicus (Norway rat)Potency31.622810
phenylephrine hydrochlorideRattus norvegicus (Norway rat)Potency0.281810
3-[(5-chloro-2-pyridinyl)amino]-2-(2-pyridinyl)-3H-isoindol-1-oneRattus norvegicus (Norway rat)Potency50.118710
1-acetyl-N-[3-(N-ethyl-3-methylanilino)propyl]-2,3-dihydroindole-5-sulfonamideRattus norvegicus (Norway rat)Potency19.952610
4-[[[3-(2-fluorophenyl)-1-methyl-5-thieno[2,3-c]pyrazolyl]-oxomethyl]amino]-1-piperidinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency44.668410
2,5-dimethyl-N-(3,4,5-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amineRattus norvegicus (Norway rat)Potency50.118710
N-(2-furanylmethyl)-3-(2,4,8,10-tetramethyl-3-pyrido[2,3]pyrazolo[2,4-a]pyrimidinyl)propanamideRattus norvegicus (Norway rat)Potency56.234110
N-[3-[4-(2,5-dimethylphenyl)-1-piperazinyl]propyl]-2-(6-methyl-3-oxo-4H-1,4-benzoxazin-2-yl)acetamideRattus norvegicus (Norway rat)Potency0.177810
N-(3-acetylphenyl)-5-propan-2-yl-3-isoxazolecarboxamideRattus norvegicus (Norway rat)Potency0.794310
N-[2-(4-morpholinyl)ethyl]-4-(phenylmethyl)-2,3-dihydro-1,4-benzothiazine-6-carboxamideRattus norvegicus (Norway rat)Potency31.622810
1-[2-(4-morpholinyl)-2-oxoethyl]-2-pyrido[2,3-b][1,4]thiazinoneRattus norvegicus (Norway rat)Potency44.668410
N-(1,3-benzodioxol-5-yl)-2-(5-methyl-2-furanyl)-3-imidazo[1,2-a]pyrazinamineRattus norvegicus (Norway rat)Potency56.234110
N-[3-(4-methyl-1-piperazinyl)propyl]-4-(phenylmethyl)-2,3-dihydro-1,4-benzothiazine-6-carboxamideRattus norvegicus (Norway rat)Potency25.118910
2-(2-chlorophenyl)-9-(3-methylphenyl)-8-oxo-7H-purine-6-carboxamideRattus norvegicus (Norway rat)Potency31.622810
N-cycloheptyl-3-(2-methoxyethyl)-2,4-dioxo-1H-quinazoline-7-carboxamideRattus norvegicus (Norway rat)Potency25.118910
5-ethyl-N-[[2-(3-pyridinyl)-4-thiazolyl]methyl]-2-thiophenesulfonamideRattus norvegicus (Norway rat)Potency50.118710
3-(3,5-dimethyl-1-pyrazolyl)-5-phenyl-1,2,4-triazineRattus norvegicus (Norway rat)Potency56.234110
nifuroxazideRattus norvegicus (Norway rat)Potency50.118710
7-hydroxy-4-methyl-1H-quinolin-2-oneRattus norvegicus (Norway rat)Potency35.481310
2-(5,7-dihydroxy-4-methyl-2-oxo-1-benzopyran-3-yl)acetic acid ethyl esterRattus norvegicus (Norway rat)Potency31.622810
7-hydroxy-6-(4-morpholinylmethyl)-2,3-dihydro-1H-cyclopenta[c][1]benzopyran-4-oneRattus norvegicus (Norway rat)Potency25.118910
(3S,3'aR,8'aS,8'bS)-5-ethyl-2'-(phenylmethyl)spiro[1H-indole-3,4'-3a,6,7,8,8a,8b-hexahydropyrrolo[3,4-a]pyrrolizine]-1',2,3'-trioneRattus norvegicus (Norway rat)Potency22.387210
3-bromo-7-hydroxy-4,8-dimethyl-1-benzopyran-2-oneRattus norvegicus (Norway rat)Potency28.183810
3,8-dibromo-7-hydroxy-4-methylchromen-2-oneRattus norvegicus (Norway rat)Potency39.810710
N3,N6-bis(2,5-dimethoxyphenyl)pyridazine-3,6-diamineRattus norvegicus (Norway rat)Potency50.118710
am 404Rattus norvegicus (Norway rat)Potency56.234110
1-(4-oxo-2-thieno[3,2-d][1,3]thiazinyl)-N-(phenylmethyl)-3-piperidinecarboxamideRattus norvegicus (Norway rat)Potency35.481310
LSM-32377Rattus norvegicus (Norway rat)Potency35.481310
4-fluoro-N-(4-fluoro-1,3-benzothiazol-2-yl)-1,3-benzothiazol-2-amineRattus norvegicus (Norway rat)Potency22.387210
N-(6-fluoro-1,3-benzothiazol-2-yl)-6,7-dihydro-[1,4]dioxino[2,3-f][1,3]benzothiazol-2-amineRattus norvegicus (Norway rat)Potency25.118910
2-(2-phenylethyl)benzo[de]isoquinoline-1,3-dioneRattus norvegicus (Norway rat)Potency44.668410
5,7-dimethyl-3-[3-(trifluoromethyl)phenyl]azo-1H-pyrazolo[1,5-a]pyrimidin-2-oneRattus norvegicus (Norway rat)Potency56.234110
3-butyl-10-phenylpyrimido[4,5-b]quinoline-2,4-dioneRattus norvegicus (Norway rat)Potency28.183810
N-[2-(3-methoxyphenyl)-4-[(4-methoxyphenyl)methoxy]-6-quinolinyl]-3-pyridinecarboxamideRattus norvegicus (Norway rat)Potency0.251210
4-[[[4-[(4-fluorophenyl)methyl]-2,3-dihydro-1,4-benzothiazin-6-yl]-oxomethyl]amino]-1-piperidinecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency35.481310
N-[3-(4-morpholinyl)propyl]-2,4-dioxo-3-(2-phenylethyl)-1H-quinazoline-7-carboxamideRattus norvegicus (Norway rat)Potency35.481310
5-chloro-N-[4-(2-thiazolo[5,4-b]pyridinyl)phenyl]-2-thiophenesulfonamideRattus norvegicus (Norway rat)Potency35.481310
3-(4-ethoxyphenyl)-1-[3-(4-morpholinyl)propyl]-1-[(1-propyl-3,4-dihydro-2H-quinolin-6-yl)methyl]ureaRattus norvegicus (Norway rat)Potency50.118710
N-(1,3-benzodioxol-5-yl)-2-(4-methylphenyl)-3-imidazo[1,2-a]pyrazinamineRattus norvegicus (Norway rat)Potency31.622810
1-(3,4-dimethylphenyl)-2,5-dioxo-3-dipyrido[1,2-d-3',4'-f]pyrimidinecarbonitrileRattus norvegicus (Norway rat)Potency4.466810
1-cyclohexyl-3-[1-[4-(phenylmethyl)-1-piperazinyl]-1-thiophen-2-ylpropan-2-yl]ureaRattus norvegicus (Norway rat)Potency10.000010
3-(2-methoxyethyl)-2,4-dioxo-N-pentyl-1H-quinazoline-7-carboxamideRattus norvegicus (Norway rat)Potency35.481310
sidnocarbRattus norvegicus (Norway rat)Potency0.158510
halometasoneRattus norvegicus (Norway rat)Potency5.011910
uncarine cRattus norvegicus (Norway rat)Potency1.122010
3-(4-nitrophenyl)-N-(4-phenylbutyl)-5-(phenylmethyl)-4,6-dihydro-3aH-pyrrolo[3,4-d]isoxazole-6a-carboxamideRattus norvegicus (Norway rat)Potency31.622810
2-ethyl-3-methoxy-N-(2-thiophen-2-ylethyl)-6-indazolecarboxamideRattus norvegicus (Norway rat)Potency0.794310
3-hydroxy-3-methyl-5-oxo-5-[[3,4,5-trihydroxy-6-[[6-methoxy-2-oxo-3-[(2-oxo-1-benzopyran-7-yl)oxy]-1-benzopyran-7-yl]oxy]-2-oxanyl]methoxy]pentanoic acidRattus norvegicus (Norway rat)Potency17.782810
[4-(2-chlorophenyl)sulfonyl-3-nitrophenyl]-[4-(phenylmethyl)-1-piperazinyl]methanoneRattus norvegicus (Norway rat)Potency44.668410
4-[3-(3-fluorophenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamideRattus norvegicus (Norway rat)Potency35.481310
3-[(3-methylphenyl)methylthio]-6-thiophen-2-ylpyridazineRattus norvegicus (Norway rat)Potency56.234110
1,2,3,4-tetrahydro-1-phenylisoquinoline hydrochlorideRattus norvegicus (Norway rat)Potency5.011910
3-[(4-methoxyphenyl)methyl]-N-(3-methoxypropyl)-2,4-dioxo-1H-quinazoline-7-carboxamideRattus norvegicus (Norway rat)Potency28.183810
N'-butan-2-yl-N-[2-(3,5-dimethyl-1-piperidinyl)-4-methyl-6-quinolinyl]butanediamideRattus norvegicus (Norway rat)Potency31.622810
3-[[(3R,4S)-2-(4-bromophenyl)-5-(3-chlorophenyl)-4-(2-methoxyphenyl)-3,4-dihydropyrazol-3-yl]-oxomethyl]-2-oxazolidinoneRattus norvegicus (Norway rat)Potency31.622810
1-(1,4-dioxan-2-yl)-N-[[3-(diphenylmethyl)-1,2,4-oxadiazol-5-yl]methyl]-N-methylmethanamineRattus norvegicus (Norway rat)Potency44.668410
dafadine BRattus norvegicus (Norway rat)Potency28.183810
2-(3,5-dimethyl-1-pyrazolyl)-1-[3-[oxo-(3-propan-2-yloxyphenyl)methyl]-1-piperidinyl]ethanoneRattus norvegicus (Norway rat)Potency31.622810
1-[[3-(3-fluorophenyl)-1-(4-methoxyphenyl)-4-pyrazolyl]methyl]-4-methoxypiperidineRattus norvegicus (Norway rat)Potency28.183810
[1-[(7-chloro-3-methyl-1H-indol-2-yl)methyl]-4-(2-phenoxyethyl)-4-piperidinyl]methanolRattus norvegicus (Norway rat)Potency50.118710
[1-[(6-chloro-2H-1-benzopyran-3-yl)methyl]-4-(2-phenoxyethyl)-4-piperidinyl]methanolRattus norvegicus (Norway rat)Potency12.589310
1-cyclohexyl-2-(1H-imidazol-2-ylmethyl)-1,3,4,9-tetrahydropyrido[3,4-b]indoleRattus norvegicus (Norway rat)Potency7.079510
2-(3,5-dimethyl-1-pyrazolyl)-N-[[3-(4-fluorophenyl)-1-(4-methylphenyl)-4-pyrazolyl]methyl]ethanamineRattus norvegicus (Norway rat)Potency28.183810
N-[3-(1-azepanyl)propyl]-3-[(4-methoxyphenyl)methyl]-2,4-dioxo-1H-quinazoline-7-carboxamideRattus norvegicus (Norway rat)Potency28.183810
N-(5-chloro-2-pyridinyl)-4H-thieno[3,2-c][1]benzopyran-2-carboxamideRattus norvegicus (Norway rat)Potency3.548110
oxytetracycline, anhydrousRattus norvegicus (Norway rat)Potency11.220210
4-hydroxy-1-(2-methylpropyl)-2-oxo-N-(2-sulfamoylphenyl)-3-quinolinecarboxamideRattus norvegicus (Norway rat)Potency3.981110
mobiflexRattus norvegicus (Norway rat)Potency1.000010
4-hydroxy-2-oxo-1-prop-2-enyl-N-(3-pyridinyl)-3-quinolinecarboxamideRattus norvegicus (Norway rat)Potency31.622810
4-hydroxy-N-(2-methyl-4-oxo-3-quinazolinyl)-1-(2-methylpropyl)-2-oxo-5,6,7,8-tetrahydroquinoline-3-carboxamideRattus norvegicus (Norway rat)Potency28.183810
suptopin 2Rattus norvegicus (Norway rat)Potency50.118710
6-[5-[[(5-cyano-4-oxo-6-phenyl-1H-pyrimidin-2-yl)thio]methyl]-2-oxo-1,3-dihydroimidazol-4-yl]-6-oxohexanoic acid ethyl esterRattus norvegicus (Norway rat)Potency44.668410
N-[4-[2-[3-(dimethylsulfamoyl)anilino]-6H-1,3,4-thiadiazin-5-yl]phenyl]acetamideRattus norvegicus (Norway rat)Potency50.118710
6-Methyl-2-phenylpyrimidin-4-olRattus norvegicus (Norway rat)Potency4.466810
5,5-diethyl-2-(2-hydroxyethylamino)-1,6-dihydrobenzo[h]quinazolin-4-oneRattus norvegicus (Norway rat)Potency31.622810
1-[(7-chloro-4-oxo-1H-quinazolin-2-yl)methyl]-4-piperidinecarboxamideRattus norvegicus (Norway rat)Potency11.220210

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
benzoic acidRattus norvegicus (Norway rat)Ki54.000011
cholineRattus norvegicus (Norway rat)Ki35.200045
nornicotineRattus norvegicus (Norway rat)IC500.090022
nornicotineRattus norvegicus (Norway rat)Ki0.030011
3-(1-methylpyrrolidin-2-yl)pyridineRattus norvegicus (Norway rat)Ki0.018122
epibatidineRattus norvegicus (Norway rat)Ki0.00023950
8-hydroxy-2-(di-n-propylamino)tetralinRattus norvegicus (Norway rat)Ki0.831811
tacrineRattus norvegicus (Norway rat)IC500.045711
arecolineRattus norvegicus (Norway rat)Ki0.270022
bmy 7378Rattus norvegicus (Norway rat)Ki1.174911
celecoxibRattus norvegicus (Norway rat)IC5026.610011
clonazepamRattus norvegicus (Norway rat)Ki0.000811
diazepamRattus norvegicus (Norway rat)Ki0.010011
flumazenilRattus norvegicus (Norway rat)Ki0.000911
indomethacinRattus norvegicus (Norway rat)IC500.004011
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-oneRattus norvegicus (Norway rat)IC501.600011
wb 4101Rattus norvegicus (Norway rat)Ki0.014811
carbacholRattus norvegicus (Norway rat)Ki0.560045
dimethylphenylpiperazinium iodideRattus norvegicus (Norway rat)Ki1.521457
thiophene-3-carboxylic acidRattus norvegicus (Norway rat)Ki24.700011
beta-erythroidineRattus norvegicus (Norway rat)Ki1.100011
cytisineRattus norvegicus (Norway rat)IC500.069211
cytisineRattus norvegicus (Norway rat)Ki0.08542021
anatabineRattus norvegicus (Norway rat)Ki0.249011
3-hydroxy-1-benzopyran-2-oneRattus norvegicus (Norway rat)Ki0.265011
laudanosineRattus norvegicus (Norway rat)Ki100.000011
anabaseineRattus norvegicus (Norway rat)Ki0.049522
dihydro-beta-erythroidineRattus norvegicus (Norway rat)IC500.030011
dihydro-beta-erythroidineRattus norvegicus (Norway rat)Ki0.480022
besipirdineRattus norvegicus (Norway rat)IC5020.000011
1-(4-pyridyl)piperazineRattus norvegicus (Norway rat)Ki10.000011
nicotineRattus norvegicus (Norway rat)IC500.004633
nicotineRattus norvegicus (Norway rat)Ki0.01247685
lobelineRattus norvegicus (Norway rat)Ki0.040011
3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazoleRattus norvegicus (Norway rat)Ki0.013958
2-(4-morpholinyl)-4h-1-benzopyran-4-oneRattus norvegicus (Norway rat)IC5010.000011
3,5-bis(trifluoromethyl)benzyl n-acetyltryptophanRattus norvegicus (Norway rat)IC505.000012
pseudonicotineRattus norvegicus (Norway rat)Ki0.038011
vareniclineRattus norvegicus (Norway rat)IC500.200022
vareniclineRattus norvegicus (Norway rat)Ki0.012999
sb 203580Rattus norvegicus (Norway rat)Ki0.090011
pozaniclineRattus norvegicus (Norway rat)Ki0.016523
2-amino-5,6-dihydro-4h-1,3-thiazineRattus norvegicus (Norway rat)IC50160.000011
3,7-diazabicyclo(3.3.1)nonaneRattus norvegicus (Norway rat)Ki0.600011
anabasineRattus norvegicus (Norway rat)Ki1.100011
6-hydroxynicotineRattus norvegicus (Norway rat)Ki1.072011
anatoxin aRattus norvegicus (Norway rat)IC500.009022
anatoxin aRattus norvegicus (Norway rat)Ki0.001222
resveratrolRattus norvegicus (Norway rat)IC500.685022
ferruginineRattus norvegicus (Norway rat)Ki0.120211
lobelineRattus norvegicus (Norway rat)Ki0.002112
cotinineRattus norvegicus (Norway rat)Ki3.000011
epibatidineRattus norvegicus (Norway rat)Ki0.000155
anatoxin aRattus norvegicus (Norway rat)Ki0.000311
ici 199441Rattus norvegicus (Norway rat)Ki0.000011
5-(6-chloro-3-pyridinyl)-9-azabicyclo[4.2.1]non-4-eneRattus norvegicus (Norway rat)Ki0.001133
arachidonyltrifluoromethaneRattus norvegicus (Norway rat)IC502.300011
pterostilbeneRattus norvegicus (Norway rat)IC500.820011
a 85380Rattus norvegicus (Norway rat)IC500.001511
a 85380Rattus norvegicus (Norway rat)Ki0.000167
ar-r 17779Rattus norvegicus (Norway rat)Ki16.000011
3-(2,4-dimethoxybenzylidene)anabaseineRattus norvegicus (Norway rat)Ki0.051011
bibp 3226Rattus norvegicus (Norway rat)Ki10.000013
semaxinibRattus norvegicus (Norway rat)IC500.500011
3,5-dihydroxy-4'-methoxystilbeneRattus norvegicus (Norway rat)IC5019.600011
sunRattus norvegicus (Norway rat)Ki0.031711
a 84543Rattus norvegicus (Norway rat)Ki0.000545
desnitroimidaclopridRattus norvegicus (Norway rat)IC500.006011
deschloroepibatidineRattus norvegicus (Norway rat)Ki0.000067
N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamideRattus norvegicus (Norway rat)IC5016.000011
N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamideRattus norvegicus (Norway rat)Ki4.000011
f-a 85380Rattus norvegicus (Norway rat)Ki0.002222
crispine aRattus norvegicus (Norway rat)Ki5.050022
methyl arachidonylfluorophosphonateRattus norvegicus (Norway rat)IC500.640011
lobelaneRattus norvegicus (Norway rat)Ki14.900011
nu 7441Rattus norvegicus (Norway rat)IC500.030011
ibodutantRattus norvegicus (Norway rat)Ki0.000111
n-methylepibatidineRattus norvegicus (Norway rat)Ki0.000022
Dihydro-beta-erythroidine hydrobromideRattus norvegicus (Norway rat)IC500.624011
Dihydro-beta-erythroidine hydrobromideRattus norvegicus (Norway rat)Ki0.485011
ku-0060648Rattus norvegicus (Norway rat)IC500.005011
sazetidine-aRattus norvegicus (Norway rat)Ki0.000388
3-bromocytisineRattus norvegicus (Norway rat)IC500.000311
sen 12333Rattus norvegicus (Norway rat)Ki10.000033
alpha-conotoxin pniaRattus norvegicus (Norway rat)IC500.007711
3-(4-hydroxy-2-methoxybenzylidene)anabaseineRattus norvegicus (Norway rat)Ki0.019011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
nornicotineRattus norvegicus (Norway rat)EC50375.000011
epibatidineRattus norvegicus (Norway rat)EC500.027457
epibatidineRattus norvegicus (Norway rat)Kd0.000044
dimethylphenylpiperazinium iodideRattus norvegicus (Norway rat)EC502.500011
mecamylamineRattus norvegicus (Norway rat)EC500.200011
2-methylpiperidineRattus norvegicus (Norway rat)Kd0.000111
2-picolineRattus norvegicus (Norway rat)Kd64,000.000011
cytisineRattus norvegicus (Norway rat)EC5024.000022
anabaseineRattus norvegicus (Norway rat)EC504.200011
nicotineRattus norvegicus (Norway rat)EC5010.73981212
nicotineRattus norvegicus (Norway rat)Kd14,352.000033
3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazoleRattus norvegicus (Norway rat)EC5060.150044
isoarecolone methiodideRattus norvegicus (Norway rat)EC50100.000011
vareniclineRattus norvegicus (Norway rat)EC500.046011
pozaniclineRattus norvegicus (Norway rat)EC50100.000011
anabasineRattus norvegicus (Norway rat)EC5030.000011
anatoxin aRattus norvegicus (Norway rat)EC500.089323
cotinineRattus norvegicus (Norway rat)EC5021.000011
trans-metanicotineRattus norvegicus (Norway rat)EC50335.010033
a 85380Rattus norvegicus (Norway rat)EC500.700022
bastadin 5Rattus norvegicus (Norway rat)EC502.200011
a 84543Rattus norvegicus (Norway rat)EC500.750011
deschloroepibatidineRattus norvegicus (Norway rat)EC503.630013

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
epibatidineRattus norvegicus (Norway rat)Affinity0.000011
epibatidineRattus norvegicus (Norway rat)K app0.000013
cytisineRattus norvegicus (Norway rat)Affinity0.000111
nicotineRattus norvegicus (Norway rat)K app0.006213