Page last updated: 2024-08-07 13:43:37
Carbonic anhydrase 13
A carbonic anhydrase 13 that is encoded in the genome of mouse. [OMA:Q9D6N1, PRO:DNx]
Synonyms
EC 4.2.1.1;
Carbonate dehydratase XIII;
Carbonic anhydrase XIII;
CA-XIII
Research
Bioassay Publications (32)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 25 (78.13) | 29.6817 |
| 2010's | 7 (21.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (105)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 4-hydroxybenzoic acid | Mus musculus (house mouse) | Ki | 257.1494 | 3 | 16 |
| hydrobromic acid | Mus musculus (house mouse) | Ki | 45,000.0000 | 1 | 1 |
| cadaverine | Mus musculus (house mouse) | Ki | 0.6300 | 1 | 1 |
| catechol | Mus musculus (house mouse) | Ki | 401.8214 | 3 | 14 |
| hydrochloric acid | Mus musculus (house mouse) | Ki | 138,000.0000 | 1 | 1 |
| coumarin | Mus musculus (house mouse) | Ki | 9.2000 | 1 | 1 |
| salicylic acid | Mus musculus (house mouse) | Ki | 165.9500 | 2 | 14 |
| gallic acid | Mus musculus (house mouse) | Ki | 9.8600 | 1 | 1 |
| 4-nitrophenylphosphate | Mus musculus (house mouse) | IC50 | 1.0500 | 1 | 1 |
| hydrogen sulfide | Mus musculus (house mouse) | Ki | 5,200.0000 | 1 | 1 |
| 4-aminophenol | Mus musculus (house mouse) | Ki | 525.7929 | 2 | 14 |
| cyanic acid | Mus musculus (house mouse) | Ki | 0.2500 | 1 | 1 |
| carbonic acid | Mus musculus (house mouse) | Ki | 72,750.0000 | 1 | 2 |
| hydrogen cyanide | Mus musculus (house mouse) | Ki | 60.0000 | 1 | 1 |
| thiocyanic acid | Mus musculus (house mouse) | Ki | 740.0000 | 1 | 1 |
| hydroquinone | Mus musculus (house mouse) | Ki | 121.6993 | 2 | 14 |
| nitric acid | Mus musculus (house mouse) | Ki | 36,000.0000 | 1 | 1 |
| phenol | Mus musculus (house mouse) | Ki | 259.3143 | 3 | 14 |
| sulfurous acid | Mus musculus (house mouse) | Ki | 75,500.0000 | 1 | 1 |
| spermidine | Mus musculus (house mouse) | Ki | 11.6000 | 1 | 1 |
| spermine | Mus musculus (house mouse) | Ki | 22.6000 | 1 | 1 |
| sulfuric acid | Mus musculus (house mouse) | Ki | 267,000.0000 | 1 | 1 |
| acetaminophen | Mus musculus (house mouse) | Ki | 149.6769 | 2 | 13 |
| acetazolamide | Mus musculus (house mouse) | IC50 | 0.7700 | 2 | 2 |
| acetazolamide | Mus musculus (house mouse) | Ki | 11.8024 | 18 | 51 |
| bumetanide | Mus musculus (house mouse) | Ki | 18.3242 | 1 | 12 |
| chlorthalidone | Mus musculus (house mouse) | Ki | 1.2972 | 2 | 14 |
| dichlorphenamide | Mus musculus (house mouse) | Ki | 11.5304 | 8 | 19 |
| ethoxzolamide | Mus musculus (house mouse) | Ki | 11.7997 | 6 | 17 |
| furosemide | Mus musculus (house mouse) | Ki | 14.6181 | 2 | 14 |
| hydrochlorothiazide | Mus musculus (house mouse) | Ki | 18.6042 | 1 | 12 |
| hydroflumethiazide | Mus musculus (house mouse) | Ki | 20.3203 | 1 | 12 |
| indapamide | Mus musculus (house mouse) | Ki | 18.7456 | 2 | 14 |
| mafenide | Mus musculus (house mouse) | Ki | 0.0410 | 2 | 2 |
| methazolamide | Mus musculus (house mouse) | Ki | 10.3324 | 9 | 20 |
| metolazone | Mus musculus (house mouse) | Ki | 22.0639 | 1 | 12 |
| resorcinol | Mus musculus (house mouse) | Ki | 282.1857 | 2 | 14 |
| imatinib | Mus musculus (house mouse) | Ki | 7.4500 | 1 | 1 |
| sulfanilamide | Mus musculus (house mouse) | Ki | 0.0320 | 2 | 2 |
| trichlormethiazide | Mus musculus (house mouse) | Ki | 43.7991 | 2 | 26 |
| trientine | Mus musculus (house mouse) | Ki | 52.0000 | 1 | 1 |
| sulfamic acid | Mus musculus (house mouse) | Ki | 21,500.0000 | 1 | 1 |
| quinethazone | Mus musculus (house mouse) | Ki | 18.1300 | 1 | 2 |
| diethylenetriamine | Mus musculus (house mouse) | Ki | 11.5000 | 1 | 1 |
| paraoxon | Mus musculus (house mouse) | IC50 | 1.0210 | 1 | 1 |
| syringic acid | Mus musculus (house mouse) | Ki | 11.0000 | 1 | 1 |
| herniarin | Mus musculus (house mouse) | Ki | 8.9000 | 1 | 1 |
| coumarin-3-carboxylic acid | Mus musculus (house mouse) | Ki | 20.3000 | 1 | 1 |
| 4-cyanophenol | Mus musculus (house mouse) | Ki | 205.7006 | 2 | 14 |
| hydrofluoric acid | Mus musculus (house mouse) | Ki | 3,000.0000 | 1 | 1 |
| n-(1-naphthyl)ethylenediamine | Mus musculus (house mouse) | Ki | 0.6200 | 1 | 1 |
| 1,6-diaminohexane | Mus musculus (house mouse) | Ki | 0.6900 | 1 | 1 |
| benzolamide | Mus musculus (house mouse) | Ki | 35.0324 | 1 | 4 |
| sodium pyrophosphate | Mus musculus (house mouse) | Ki | 730.0000 | 1 | 1 |
| nitrous acid | Mus musculus (house mouse) | Ki | 12,600.0000 | 1 | 1 |
| hydrazoic acid | Mus musculus (house mouse) | Ki | 4,800.0000 | 1 | 1 |
| hydroiodic acid | Mus musculus (house mouse) | Ki | 5,400.0000 | 1 | 1 |
| sodium selenate | Mus musculus (house mouse) | Ki | 484,000.0000 | 1 | 1 |
| 7-ethoxycoumarin | Mus musculus (house mouse) | Ki | 4.9000 | 1 | 1 |
| foscarnet sodium | Mus musculus (house mouse) | Ki | 870.0000 | 1 | 1 |
| sodium persulfate | Mus musculus (house mouse) | Ki | 4,310.0000 | 1 | 1 |
| benzeneboronic acid | Mus musculus (house mouse) | Ki | 2,850.0000 | 1 | 1 |
| disulphane | Mus musculus (house mouse) | Ki | 0.0024 | 1 | 1 |
| brinzolamide | Mus musculus (house mouse) | Ki | 0.0100 | 1 | 1 |
| 2-aminobenzenesulfonamide | Mus musculus (house mouse) | Ki | 0.0430 | 2 | 2 |
| 3,7-diazanonane-1,9-diamine | Mus musculus (house mouse) | Ki | 66.0000 | 1 | 1 |
| sulfamide | Mus musculus (house mouse) | Ki | 140.0000 | 2 | 2 |
| valdecoxib | Mus musculus (house mouse) | Ki | 0.4250 | 1 | 1 |
| 1-naphthylacetylspermine | Mus musculus (house mouse) | Ki | 10.2000 | 1 | 1 |
| 4-(2-aminoethyl)benzenesulfonamide | Mus musculus (house mouse) | Ki | 0.0430 | 2 | 2 |
| rwj 37947 | Mus musculus (house mouse) | Ki | 0.0360 | 1 | 1 |
| ferulic acid | Mus musculus (house mouse) | Ki | 12.2000 | 2 | 2 |
| ditiocarb sodium | Mus musculus (house mouse) | Ki | 56.0000 | 1 | 1 |
| hydroxyphenethylferulate | Mus musculus (house mouse) | Ki | 0.9300 | 1 | 1 |
| trans-4-coumaric acid | Mus musculus (house mouse) | Ki | 10.1000 | 2 | 2 |
| s 1033 | Mus musculus (house mouse) | Ki | 4.6650 | 1 | 1 |
| caffeic acid | Mus musculus (house mouse) | Ki | 10.9000 | 2 | 2 |
| 7-methoxy-2-oxo-1-benzopyran-3-carboxylic acid ethyl ester | Mus musculus (house mouse) | Ki | 0.0450 | 1 | 1 |
| quercetin | Mus musculus (house mouse) | Ki | 9.0300 | 1 | 1 |
| ellagic acid | Mus musculus (house mouse) | Ki | 10.3000 | 1 | 1 |
| dorzolamide | Mus musculus (house mouse) | Ki | 46.0448 | 7 | 18 |
| topiramate | Mus musculus (house mouse) | Ki | 30.5338 | 6 | 26 |
| irosustat | Mus musculus (house mouse) | Ki | 54.5044 | 2 | 13 |
| sodium bisulfate | Mus musculus (house mouse) | Ki | 710.0000 | 1 | 1 |
| dodoneine | Mus musculus (house mouse) | Ki | 9.2700 | 1 | 1 |
Drugs with Other Measurements
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of α- but not of β-, γ- and ζ-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 20, Issue:21, 2010
Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 18, Issue:7, 2008
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 18, Issue:14, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 18, Issue:7, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 17, Issue:17, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 17, Issue:17, 2007
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Inhibition of mammalian carbonic anhydrase isoforms I-XIV with a series of phenolic acid esters.Bioorganic & medicinal chemistry, , Nov-15, Volume: 23, Issue:22, 2015
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Inhibition of mammalian carbonic anhydrase isoforms I-XIV with a series of phenolic acid esters.Bioorganic & medicinal chemistry, , Nov-15, Volume: 23, Issue:22, 2015
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Inhibition of mammalian carbonic anhydrase isoforms I-XIV with a series of phenolic acid esters.Bioorganic & medicinal chemistry, , Nov-15, Volume: 23, Issue:22, 2015
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 17, Issue:17, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006