Page last updated: 2024-08-07 15:52:45
Beta-2 adrenergic receptor
A beta-2 adrenergic receptor that is encoded in the genome of rat. [OMA:P10608, PRO:DNx]
Synonyms
Beta-2 adrenoreceptor;
Beta-2 adrenoceptor
Research
Bioassay Publications (22)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 10 (45.45) | 18.7374 |
| 1990's | 8 (36.36) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (30)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| alprenolol | Rattus norvegicus (Norway rat) | Kapp | 0.0200 | 1 | 1 |
| bunolol | Rattus norvegicus (Norway rat) | Kapp | 0.0170 | 1 | 1 |
| pindolol | Rattus norvegicus (Norway rat) | Kapp | 0.0930 | 1 | 1 |
| practolol | Rattus norvegicus (Norway rat) | Kapp | 313.0000 | 1 | 1 |
| propranolol | Rattus norvegicus (Norway rat) | Kapp | 0.0180 | 1 | 1 |
Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity.Journal of medicinal chemistry, , Nov-26, Volume: 36, Issue:24, 1993
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996
Synthesis and biological evaluation of some 2-amino-4-aryl-3H-1,5-benzodiazepine analogues of clozapine.Journal of medicinal chemistry, , Volume: 21, Issue:9, 1978
2-Amino-4-benzyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridines: novel selective beta3-adrenoceptor agonists.Journal of medicinal chemistry, , Jun-17, Volume: 42, Issue:12, 1999
Effect of fluorine substitution on the adrenergic properties of 3-(tert-butylamino)-1-(3,4-dihydroxyphenoxy)-2-propanol.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
Carbostyril derivatives having potent beta-adrenergic agonist properties.Journal of medicinal chemistry, , Volume: 30, Issue:9, 1987
Syntheses and adrenergic agonist properties of ring-fluorinated isoproterenols.Journal of medicinal chemistry, , Volume: 25, Issue:6, 1982
Synthesis and adrenergic activity of a new series of N-aryl dicyclopropyl ketone oxime ethers: SAR and stereochemical aspects.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
Flavones. 2. Synthesis and structure-activity relationship of flavodilol and its analogues, a novel class of antihypertensive agents with catecholamine depleting properties.Journal of medicinal chemistry, , Volume: 32, Issue:1, 1989
Syntheses and adrenergic agonist properties of ring-fluorinated isoproterenols.Journal of medicinal chemistry, , Volume: 25, Issue:6, 1982
Cardioselectivity of beta-adrenoceptor blocking agents 1. 1-[(4-Hydroxyphenethyl)amino]-3-(aryloxy)propan-2-ols.Journal of medicinal chemistry, , Volume: 22, Issue:6, 1979
Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity.Journal of medicinal chemistry, , Nov-26, Volume: 36, Issue:24, 1993
Discovery of novel N-phenylglycine derivatives as potent and selective beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence.Journal of medicinal chemistry, , Apr-26, Volume: 44, Issue:9, 2001
Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
Discovery of novel N-phenylglycine derivatives as potent and selective beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence.Journal of medicinal chemistry, , Apr-26, Volume: 44, Issue:9, 2001
Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.Journal of medicinal chemistry, , Aug-07, Volume: 35, Issue:16, 1992
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.Journal of medicinal chemistry, , Jul-05, Volume: 39, Issue:14, 1996
Synthesis and biological evaluation of some 2-amino-4-aryl-3H-1,5-benzodiazepine analogues of clozapine.Journal of medicinal chemistry, , Volume: 21, Issue:9, 1978