Proteins > Metabotropic glutamate receptor 2
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Metabotropic glutamate receptor 2
A metabotropic glutamate receptor 2 that is encoded in the genome of rat. [OMA:P31421, PRO:DNx]
Synonyms
mGluR2
Research
Bioassay Publications (22)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (22.73) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 7 (31.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (20)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.Journal of medicinal chemistry, , Feb-11, Volume: 59, Issue:3, 2016
Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 25, Issue:12, 2015
Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.Journal of medicinal chemistry, , Sep-12, Volume: 45, Issue:19, 2002
New probes of the agonist binding site of metabotropic glutamate receptors.Bioorganic & medicinal chemistry letters, , Jun-18, Volume: 11, Issue:12, 2001
1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 9, Issue:12, 1999
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.Journal of medicinal chemistry, , Sep-12, Volume: 45, Issue:19, 2002
(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids.Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 9, Issue:12, 1999
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.Journal of medicinal chemistry, , Jan-15, Volume: 47, Issue:2, 2004
(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Synthesis and Pharmacological Characterization of C4Journal of medicinal chemistry, , 03-22, Volume: 61, Issue:6, 2018
Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist.Journal of medicinal chemistry, , Aug-11, Volume: 48, Issue:16, 2005
Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists.Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.Journal of medicinal chemistry, , Jan-15, Volume: 47, Issue:2, 2004
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.Journal of medicinal chemistry, , Feb-11, Volume: 59, Issue:3, 2016
A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.Journal of medicinal chemistry, , Apr-08, Volume: 53, Issue:7, 2010
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.Journal of medicinal chemistry, , Jan-15, Volume: 47, Issue:2, 2004
Metabotropic glutamate receptors: novel targets for drug development.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Synthesis of N(1)-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors.Bioorganic & medicinal chemistry letters, , Jul-23, Volume: 11, Issue:14, 2001
1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 9, Issue:12, 1999
Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation.Journal of medicinal chemistry, , May-06, Volume: 42, Issue:9, 1999
Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists.Journal of medicinal chemistry, , Aug-26, Volume: 47, Issue:18, 2004
2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors.Bioorganic & medicinal chemistry letters, , Oct-20, Volume: 8, Issue:20, 1998
Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists.Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence.Journal of medicinal chemistry, , May-22, Volume: 57, Issue:10, 2014
Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats.Journal of medicinal chemistry, , Jan-13, Volume: 54, Issue:1, 2011