Page last updated: 2024-08-07 16:25:41
Substance-P receptor
A substance-P receptor that is encoded in the genome of guinea pig. [OMA:P30547, PRO:DNx]
Synonyms
SPR;
NK-1 receptor;
NK-1R;
Tachykinin receptor 1
Research
Bioassay Publications (16)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (67)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| catechin | Cavia porcellus (domestic guinea pig) | IC50 | 100.0000 | 1 | 1 |
| aspirin | Cavia porcellus (domestic guinea pig) | IC50 | 2.4000 | 1 | 1 |
| ibuprofen | Cavia porcellus (domestic guinea pig) | IC50 | 1.1000 | 1 | 1 |
| indomethacin | Cavia porcellus (domestic guinea pig) | IC50 | 5.7000 | 1 | 1 |
| tryptophan | Cavia porcellus (domestic guinea pig) | IC50 | 500.0000 | 1 | 3 |
| D-tryptophan | Cavia porcellus (domestic guinea pig) | IC50 | 500.0000 | 1 | 3 |
| hesperidin | Cavia porcellus (domestic guinea pig) | IC50 | 100.0000 | 1 | 1 |
| substance p | Cavia porcellus (domestic guinea pig) | Ki | 0.0505 | 1 | 1 |
| mifepristone | Cavia porcellus (domestic guinea pig) | IC50 | 0.0015 | 2 | 2 |
| n-acetyltyrosine | Cavia porcellus (domestic guinea pig) | IC50 | 500.0000 | 1 | 3 |
| carbobenzoxyphenylalanine | Cavia porcellus (domestic guinea pig) | IC50 | 40.0000 | 1 | 3 |
| tert-butyloxycarbonyltryptophan | Cavia porcellus (domestic guinea pig) | IC50 | 10.0000 | 1 | 3 |
| benzyloxycarbonyltryptophan | Cavia porcellus (domestic guinea pig) | IC50 | 2.5000 | 1 | 3 |
| cp 96345 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0004 | 1 | 1 |
| 7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one | Cavia porcellus (domestic guinea pig) | IC50 | 0.0320 | 1 | 1 |
| sr 140333 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0000 | 1 | 1 |
| (+)-epicatechin | Cavia porcellus (domestic guinea pig) | IC50 | 100.0000 | 1 | 1 |
| scutellarin | Cavia porcellus (domestic guinea pig) | IC50 | 50.6000 | 1 | 1 |
| naringenin | Cavia porcellus (domestic guinea pig) | IC50 | 100.0000 | 1 | 1 |
| gs 4071 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0150 | 1 | 1 |
| likviriton | Cavia porcellus (domestic guinea pig) | IC50 | 100.0000 | 1 | 1 |
| gl-4 | Cavia porcellus (domestic guinea pig) | Ki | 10.9000 | 1 | 1 |
| quercetin | Cavia porcellus (domestic guinea pig) | IC50 | 58.4000 | 1 | 1 |
| formononetin | Cavia porcellus (domestic guinea pig) | IC50 | 100.0000 | 1 | 1 |
| vitexin | Cavia porcellus (domestic guinea pig) | IC50 | 46.5000 | 1 | 1 |
| apigenin | Cavia porcellus (domestic guinea pig) | IC50 | 31.6000 | 1 | 1 |
| luteolin | Cavia porcellus (domestic guinea pig) | IC50 | 33.7000 | 1 | 1 |
| luteolin-7-glucoside | Cavia porcellus (domestic guinea pig) | IC50 | 47.4000 | 1 | 1 |
| rutin | Cavia porcellus (domestic guinea pig) | IC50 | 52.2000 | 1 | 1 |
| kaempferol | Cavia porcellus (domestic guinea pig) | IC50 | 58.6000 | 1 | 1 |
| genistein | Cavia porcellus (domestic guinea pig) | IC50 | 77.1000 | 1 | 1 |
| sulfuretin | Cavia porcellus (domestic guinea pig) | IC50 | 29.6000 | 1 | 1 |
| chrysin | Cavia porcellus (domestic guinea pig) | IC50 | 45.7000 | 1 | 1 |
| hispidulin | Cavia porcellus (domestic guinea pig) | IC50 | 46.3000 | 1 | 1 |
| myricetin | Cavia porcellus (domestic guinea pig) | IC50 | 82.6000 | 1 | 1 |
| daidzein | Cavia porcellus (domestic guinea pig) | IC50 | 37.1000 | 1 | 1 |
| kaempferol-7-methyl ether | Cavia porcellus (domestic guinea pig) | IC50 | 51.5000 | 1 | 1 |
| sophoricoside | Cavia porcellus (domestic guinea pig) | IC50 | 100.0000 | 1 | 1 |
| biphalin | Cavia porcellus (domestic guinea pig) | Ki | 0.0026 | 1 | 1 |
| enkephalin, leucine-2-alanine | Cavia porcellus (domestic guinea pig) | Ki | 0.0013 | 1 | 1 |
| pd 154075 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0059 | 1 | 1 |
| men 11558 | Cavia porcellus (domestic guinea pig) | Ki | 0.0020 | 1 | 1 |
| fauc 213 | Cavia porcellus (domestic guinea pig) | Ki | 3.4000 | 1 | 1 |
| r 1487 | Cavia porcellus (domestic guinea pig) | IC50 | 40.0000 | 1 | 1 |
| pamapimod | Cavia porcellus (domestic guinea pig) | IC50 | 29.0000 | 1 | 1 |
| azd1283 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0250 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| dnk 333 | Cavia porcellus (domestic guinea pig) | Kd | 0.0118 | 1 | 2 |
Drugs with Other Measurements