spermidine has been researched along with Necrosis in 8 studies
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Kidney ischemia and reperfusion injury (IRI) is associated with a high mortality rate, which is attributed to tubular oxidative stress and necrosis; however, an effective approach to limit IRI remains elusive." | 5.46 | Spermidine rescues proximal tubular cells from oxidative stress and necrosis after ischemic acute kidney injury. ( Kim, J, 2017) |
| " This study investigated the impact of polyamines (spermidine and spermine) on ischemia/reperfusion injury (IRI) and liver regeneration." | 3.83 | Oral administration of polyamines ameliorates liver ischemia/reperfusion injury and promotes liver regeneration in rats. ( Fujimoto, Y; Iida, T; Kaido, T; Kasahara, N; Masano, Y; Okumura, S; Teratani, T; Tsuruyama, T; Uemoto, S; Uemura, T; Yagi, S; Zhao, X, 2016) |
| "Kidney ischemia and reperfusion injury (IRI) is associated with a high mortality rate, which is attributed to tubular oxidative stress and necrosis; however, an effective approach to limit IRI remains elusive." | 1.46 | Spermidine rescues proximal tubular cells from oxidative stress and necrosis after ischemic acute kidney injury. ( Kim, J, 2017) |
| "Spermidine is an endogenous biological polyamine that exhibits broad longevity-extending activities via the induction of autophagy." | 1.43 | Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy. ( De Meyer, GRY; Kurdi, A; Martinet, W; Michiels, CF; Timmermans, JP, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, J | 1 |
| Okumura, S | 1 |
| Teratani, T | 1 |
| Fujimoto, Y | 1 |
| Zhao, X | 1 |
| Tsuruyama, T | 1 |
| Masano, Y | 1 |
| Kasahara, N | 1 |
| Iida, T | 1 |
| Yagi, S | 1 |
| Uemura, T | 1 |
| Kaido, T | 1 |
| Uemoto, S | 1 |
| Michiels, CF | 1 |
| Kurdi, A | 1 |
| Timmermans, JP | 1 |
| De Meyer, GRY | 1 |
| Martinet, W | 1 |
| Eisenberg, T | 1 |
| Knauer, H | 1 |
| Schauer, A | 1 |
| Büttner, S | 1 |
| Ruckenstuhl, C | 1 |
| Carmona-Gutierrez, D | 1 |
| Ring, J | 1 |
| Schroeder, S | 1 |
| Magnes, C | 1 |
| Antonacci, L | 1 |
| Fussi, H | 1 |
| Deszcz, L | 1 |
| Hartl, R | 1 |
| Schraml, E | 1 |
| Criollo, A | 1 |
| Megalou, E | 1 |
| Weiskopf, D | 1 |
| Laun, P | 1 |
| Heeren, G | 1 |
| Breitenbach, M | 1 |
| Grubeck-Loebenstein, B | 1 |
| Herker, E | 1 |
| Fahrenkrog, B | 1 |
| Fröhlich, KU | 1 |
| Sinner, F | 1 |
| Tavernarakis, N | 1 |
| Minois, N | 1 |
| Kroemer, G | 1 |
| Madeo, F | 1 |
| Glaeser, SP | 1 |
| Falsen, E | 1 |
| Busse, HJ | 1 |
| Kämpfer, P | 1 |
| Sol, V | 1 |
| Lamarche, F | 1 |
| Enache, M | 1 |
| Garcia, G | 1 |
| Granet, R | 1 |
| Guilloton, M | 1 |
| Blais, JC | 1 |
| Krausz, P | 1 |
| Ernestus, RI | 1 |
| Röhn, G | 1 |
| Schröder, R | 1 |
| Els, T | 1 |
| Lee, JY | 1 |
| Klug, N | 1 |
| Paschen, W | 1 |
| Foster, JR | 1 |
| Smith, LL | 1 |
| Hext, PM | 1 |
| Brammer, A | 1 |
| Soames, AR | 1 |
| Wyatt, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function in Healthy Older Adults With Subjective Cognitive Decline[NCT02755246] | Phase 2 | 30 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function and Biomarkers in Elderly Individuals With Subjective Cognitive Decline[NCT03094546] | Phase 2 | 100 participants (Actual) | Interventional | 2017-01-31 | Completed | ||
| Autophagy Characterization and Multi-level Molecular Profiling of Spermidine Supplementation: a Clinical Study[NCT04823806] | 80 participants (Anticipated) | Interventional | 2020-12-01 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for spermidine and Necrosis
| Article | Year |
|---|---|
Spermidine rescues proximal tubular cells from oxidative stress and necrosis after ischemic acute kidney injury.
Topics: Animals; Antioxidants; Cell Culture Techniques; Disease Models, Animal; Gene Knockdown Techniques; H | 2017 |
Oral administration of polyamines ameliorates liver ischemia/reperfusion injury and promotes liver regeneration in rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cell Pr | 2016 |
Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy.
Topics: Animals; Atherosclerosis; Autophagy; Cholesterol; Humans; Lipids; Macrophages; Male; Mice; Mice, Kno | 2016 |
Induction of autophagy by spermidine promotes longevity.
Topics: Acetylation; Adult; Animals; Autophagy; Caenorhabditis elegans; Drosophila melanogaster; Female; HeL | 2009 |
Induction of autophagy by spermidine promotes longevity.
Topics: Acetylation; Adult; Animals; Autophagy; Caenorhabditis elegans; Drosophila melanogaster; Female; HeL | 2009 |
Induction of autophagy by spermidine promotes longevity.
Topics: Acetylation; Adult; Animals; Autophagy; Caenorhabditis elegans; Drosophila melanogaster; Female; HeL | 2009 |
Induction of autophagy by spermidine promotes longevity.
Topics: Acetylation; Adult; Animals; Autophagy; Caenorhabditis elegans; Drosophila melanogaster; Female; HeL | 2009 |
Induction of autophagy by spermidine promotes longevity.
Topics: Acetylation; Adult; Animals; Autophagy; Caenorhabditis elegans; Drosophila melanogaster; Female; HeL | 2009 |
Induction of autophagy by spermidine promotes longevity.
Topics: Acetylation; Adult; Animals; Autophagy; Caenorhabditis elegans; Drosophila melanogaster; Female; HeL | 2009 |
Induction of autophagy by spermidine promotes longevity.
Topics: Acetylation; Adult; Animals; Autophagy; Caenorhabditis elegans; Drosophila melanogaster; Female; HeL | 2009 |
Induction of autophagy by spermidine promotes longevity.
Topics: Acetylation; Adult; Animals; Autophagy; Caenorhabditis elegans; Drosophila melanogaster; Female; HeL | 2009 |
Induction of autophagy by spermidine promotes longevity.
Topics: Acetylation; Adult; Animals; Autophagy; Caenorhabditis elegans; Drosophila melanogaster; Female; HeL | 2009 |
Paenibacillus vulneris sp. nov., isolated from a necrotic wound.
Topics: Adult; Bacterial Typing Techniques; DNA, Bacterial; Fatty Acids; Humans; Male; Molecular Sequence Da | 2013 |
Polyamine conjugates of meso-tritolylporphyrin and protoporphyrin IX: potential agents for photodynamic therapy of cancers.
Topics: Antineoplastic Agents; Dihematoporphyrin Ether; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Posi | 2006 |
Polyamine metabolism in gliomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; F | 1996 |
Target cell toxicity of inhaled spermidine in rat lungs.
Topics: Administration, Inhalation; Animals; Bronchi; Cell Survival; Lung; Male; Microscopy, Electron; Necro | 1990 |