Page last updated: 2024-08-07 16:01:35
Neuromedin-K receptor
A neuromedin-K receptor that is encoded in the genome of rat. [OMA:P16177, PRO:DNx]
Synonyms
NKR;
NK-3 receptor;
NK-3R;
Neurokinin B receptor;
Tachykinin receptor 3
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| substance p | Rattus norvegicus (Norway rat) | EC50 | 7.5000 | 1 | 1 |
| cp 96345 | Rattus norvegicus (Norway rat) | Kd | 2.5119 | 1 | 1 |
| senktide | Rattus norvegicus (Norway rat) | EC50 | 0.0068 | 2 | 2 |
| neurokinin a | Rattus norvegicus (Norway rat) | EC50 | 0.5630 | 1 | 1 |
| neurokinin b | Rattus norvegicus (Norway rat) | EC50 | 0.0063 | 1 | 1 |
Development of novel neurokinin 3 receptor (NK3R) selective agonists with resistance to proteolytic degradation.Journal of medicinal chemistry, , Oct-23, Volume: 57, Issue:20, 2014
Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P.Journal of medicinal chemistry, , Aug-02, Volume: 39, Issue:16, 1996
Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.Journal of medicinal chemistry, , Apr-12, Volume: 39, Issue:8, 1996
Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).Journal of medicinal chemistry, , Apr-09, Volume: 58, Issue:7, 2015
Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 21, Issue:7, 2011
Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).Journal of medicinal chemistry, , Apr-09, Volume: 58, Issue:7, 2015
Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 21, Issue:7, 2011