Proteins > Sodium-dependent serotonin transporter
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Sodium-dependent serotonin transporter
A sodium-dependent serotonin transporter that is encoded in the genome of rat. [OMA:P31652, PRO:DNx]
Synonyms
SERT;
5HT transporter;
5HTT;
Solute carrier family 6 member 4
Research
Bioassay Publications (134)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 7 (5.22) | 18.7374 |
| 1990's | 31 (23.13) | 18.2507 |
| 2000's | 64 (47.76) | 29.6817 |
| 2010's | 28 (20.90) | 24.3611 |
| 2020's | 4 (2.99) | 2.80 |
Compounds (117)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 8-hydroxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| 8-hydroxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | Ki | 3.9811 | 1 | 1 |
| 3,4-methylenedioxyamphetamine | Rattus norvegicus (Norway rat) | IC50 | 0.9960 | 1 | 1 |
| n-methyl-3,4-methylenedioxyamphetamine | Rattus norvegicus (Norway rat) | IC50 | 1.0600 | 1 | 1 |
| tacrine | Rattus norvegicus (Norway rat) | IC50 | 19.0000 | 1 | 1 |
| acetazolamide | Rattus norvegicus (Norway rat) | Ki | 0.1310 | 2 | 2 |
| rtki cpd | Rattus norvegicus (Norway rat) | IC50 | 0.5600 | 1 | 1 |
| citalopram | Rattus norvegicus (Norway rat) | IC50 | 0.0027 | 3 | 3 |
| desipramine | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 1 |
| desipramine | Rattus norvegicus (Norway rat) | Ki | 0.1630 | 1 | 1 |
| fluoxetine | Rattus norvegicus (Norway rat) | IC50 | 0.0538 | 3 | 4 |
| fluoxetine | Rattus norvegicus (Norway rat) | Ki | 0.0066 | 12 | 14 |
| vanoxerine | Rattus norvegicus (Norway rat) | IC50 | 0.0969 | 6 | 6 |
| vanoxerine | Rattus norvegicus (Norway rat) | Ki | 0.0878 | 11 | 13 |
| gbr 12935 | Rattus norvegicus (Norway rat) | IC50 | 0.4033 | 3 | 3 |
| gbr 12935 | Rattus norvegicus (Norway rat) | Ki | 0.5183 | 5 | 6 |
| haloperidol | Rattus norvegicus (Norway rat) | Ki | 0.0342 | 1 | 1 |
| velnacrine | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 1 |
| imipramine | Rattus norvegicus (Norway rat) | IC50 | 0.8100 | 1 | 1 |
| imipramine | Rattus norvegicus (Norway rat) | Ki | 0.0290 | 2 | 2 |
| 1-methyl-3-isobutylxanthine | Rattus norvegicus (Norway rat) | Ki | 3.0000 | 1 | 1 |
| loxapine | Rattus norvegicus (Norway rat) | Ki | 0.0210 | 1 | 1 |
| 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one | Rattus norvegicus (Norway rat) | Ki | 6.0000 | 1 | 1 |
| mazindol | Rattus norvegicus (Norway rat) | IC50 | 0.2310 | 1 | 1 |
| mazindol | Rattus norvegicus (Norway rat) | Ki | 0.2475 | 1 | 1 |
| meperidine | Rattus norvegicus (Norway rat) | Ki | 0.4120 | 1 | 1 |
| mianserin | Rattus norvegicus (Norway rat) | IC50 | 2.9000 | 1 | 1 |
| mirtazapine | Rattus norvegicus (Norway rat) | IC50 | 0.7000 | 2 | 3 |
| modafinil | Rattus norvegicus (Norway rat) | IC50 | 300.0000 | 2 | 2 |
| modafinil | Rattus norvegicus (Norway rat) | Ki | 31.3000 | 1 | 1 |
| nisoxetine | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 2 |
| nisoxetine | Rattus norvegicus (Norway rat) | Ki | 0.0014 | 1 | 1 |
| nomifensine | Rattus norvegicus (Norway rat) | IC50 | 3.1150 | 2 | 2 |
| pindolol | Rattus norvegicus (Norway rat) | Ki | 7.0000 | 1 | 1 |
| quipazine | Rattus norvegicus (Norway rat) | Ki | 0.0370 | 2 | 2 |
| 6-nitroquipazine | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 4 | 6 |
| rolipram | Rattus norvegicus (Norway rat) | IC50 | 0.0950 | 1 | 1 |
| venlafaxine | Rattus norvegicus (Norway rat) | IC50 | 0.3955 | 2 | 2 |
| venlafaxine | Rattus norvegicus (Norway rat) | Ki | 0.0385 | 2 | 2 |
| n-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-n-(2-pyridinyl)cyclohexanecarboxamide | Rattus norvegicus (Norway rat) | Ki | 0.6669 | 2 | 3 |
| meperidine hydrochloride | Rattus norvegicus (Norway rat) | Ki | 0.4130 | 2 | 2 |
| spironolactone | Rattus norvegicus (Norway rat) | IC50 | 6.9200 | 1 | 1 |
| phencyclidine | Rattus norvegicus (Norway rat) | Ki | 1.0900 | 1 | 4 |
| 1,3-ditolylguanidine | Rattus norvegicus (Norway rat) | Ki | 0.0639 | 1 | 1 |
| alpha-naphthoflavone | Rattus norvegicus (Norway rat) | IC50 | 0.0500 | 1 | 1 |
| vancomycin | Rattus norvegicus (Norway rat) | Ki | 0.0501 | 1 | 1 |
| 11-(4-methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine | Rattus norvegicus (Norway rat) | Ki | 0.4200 | 1 | 1 |
| 2-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine | Rattus norvegicus (Norway rat) | Ki | 0.0160 | 1 | 1 |
| 5,6-dihydroxytryptamine | Rattus norvegicus (Norway rat) | IC50 | 6.0000 | 1 | 1 |
| talopram | Rattus norvegicus (Norway rat) | IC50 | 1.4000 | 1 | 1 |
| talopram | Rattus norvegicus (Norway rat) | Ki | 0.7950 | 1 | 1 |
| 4-methoxyamphetamine | Rattus norvegicus (Norway rat) | IC50 | 0.1730 | 1 | 1 |
| 1-(3-chloro-5-benzo[b][1]benzoxepinyl)-4-methylpiperazine | Rattus norvegicus (Norway rat) | Ki | 0.0025 | 1 | 1 |
| talsupram | Rattus norvegicus (Norway rat) | IC50 | 0.8500 | 1 | 1 |
| paroxetine | Rattus norvegicus (Norway rat) | IC50 | 0.0003 | 1 | 1 |
| paroxetine | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 2 | 3 |
| indalpine | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| rimcazole | Rattus norvegicus (Norway rat) | Ki | 1.2675 | 2 | 2 |
| atomoxetine | Rattus norvegicus (Norway rat) | Ki | 0.0770 | 1 | 1 |
| (S)-nomifensine | Rattus norvegicus (Norway rat) | IC50 | 0.8300 | 1 | 1 |
| duloxetine | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| fluoxetine hydrochloride | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| paroxetine hydrochloride | Rattus norvegicus (Norway rat) | Ki | 0.0000 | 1 | 1 |
| sertraline hydrochloride | Rattus norvegicus (Norway rat) | IC50 | 0.0700 | 1 | 1 |
| sertraline | Rattus norvegicus (Norway rat) | IC50 | 0.1743 | 2 | 3 |
| atipamezole | Rattus norvegicus (Norway rat) | Ki | 3.1623 | 1 | 1 |
| rivastigmine | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol | Rattus norvegicus (Norway rat) | Ki | 0.3910 | 1 | 1 |
| desvenlafaxine | Rattus norvegicus (Norway rat) | Ki | 0.3240 | 1 | 1 |
| cilomilast | Rattus norvegicus (Norway rat) | IC50 | 0.0620 | 1 | 1 |
| 4-methylthioamphetamine | Rattus norvegicus (Norway rat) | IC50 | 0.2070 | 1 | 1 |
| dexmethylphenidate | Rattus norvegicus (Norway rat) | IC50 | 224.0000 | 1 | 1 |
| sb 203580 | Rattus norvegicus (Norway rat) | IC50 | 0.0100 | 1 | 1 |
| sorafenib | Rattus norvegicus (Norway rat) | IC50 | 0.0011 | 1 | 1 |
| eplerenone | Rattus norvegicus (Norway rat) | IC50 | 8.9400 | 1 | 1 |
| cocaine | Rattus norvegicus (Norway rat) | IC50 | 0.8885 | 15 | 18 |
| cocaine | Rattus norvegicus (Norway rat) | Ki | 0.5521 | 18 | 27 |
| mycophenolic acid | Rattus norvegicus (Norway rat) | IC50 | 0.0110 | 1 | 1 |
| roflumilast | Rattus norvegicus (Norway rat) | IC50 | 0.5002 | 2 | 2 |
| cocaine hydrochloride | Rattus norvegicus (Norway rat) | Ki | 0.3060 | 1 | 1 |
| benztropine | Rattus norvegicus (Norway rat) | Ki | 5.1500 | 1 | 1 |
| (R)-fluoxetine | Rattus norvegicus (Norway rat) | Ki | 0.0308 | 1 | 1 |
| 2-[(2-ethoxyphenoxy)-phenylmethyl]morpholine | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 2 |
| 2-[(2-ethoxyphenoxy)-phenylmethyl]morpholine | Rattus norvegicus (Norway rat) | Ki | 0.0090 | 1 | 1 |
| amiflamine | Rattus norvegicus (Norway rat) | IC50 | 0.1000 | 1 | 1 |
| n,n-dimethylepinephrine | Rattus norvegicus (Norway rat) | IC50 | 3,600.0000 | 1 | 1 |
| n,n-dimethylepinephrine | Rattus norvegicus (Norway rat) | Ki | 390.0000 | 1 | 1 |
| 3-[bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane | Rattus norvegicus (Norway rat) | Ki | 3.2600 | 1 | 2 |
| le 300 | Rattus norvegicus (Norway rat) | Ki | 0.0127 | 1 | 1 |
| quercetin | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| genistein | Rattus norvegicus (Norway rat) | IC50 | 0.3950 | 1 | 1 |
| pulmicort | Rattus norvegicus (Norway rat) | IC50 | 27.1000 | 1 | 1 |
| morphine | Rattus norvegicus (Norway rat) | Ki | 0.0018 | 1 | 1 |
| sophoricoside | Rattus norvegicus (Norway rat) | IC50 | 10.6000 | 1 | 1 |
| fluvoxamine | Rattus norvegicus (Norway rat) | IC50 | 0.5400 | 1 | 1 |
| fosbretabulin | Rattus norvegicus (Norway rat) | IC50 | 1.0800 | 1 | 1 |
| zimeldine | Rattus norvegicus (Norway rat) | IC50 | 4.5000 | 1 | 1 |
| levomilnacipran | Rattus norvegicus (Norway rat) | Ki | 0.0085 | 2 | 3 |
| vilazodone | Rattus norvegicus (Norway rat) | IC50 | 0.0067 | 4 | 4 |
| dov 216303 | Rattus norvegicus (Norway rat) | IC50 | 0.0328 | 2 | 3 |
| [2-[[2-[(dimethylamino)methyl]phenyl]thio]-5-iodophenyl]methanol | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 2 | 2 |
| vn2222 | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
| l 006235 | Rattus norvegicus (Norway rat) | IC50 | 0.7900 | 1 | 1 |
| vortioxetine | Rattus norvegicus (Norway rat) | IC50 | 0.0029 | 2 | 2 |
| methyl 4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylate | Rattus norvegicus (Norway rat) | Ki | 8.4900 | 1 | 1 |
| n,n-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine | Rattus norvegicus (Norway rat) | Ki | 0.0014 | 2 | 2 |
| 5-iodo-6-nitro-2-piperazinylquinoline | Rattus norvegicus (Norway rat) | Ki | 0.0002 | 1 | 1 |
| balicatib | Rattus norvegicus (Norway rat) | IC50 | 2.9000 | 1 | 1 |
| 77-lh-28-1 | Rattus norvegicus (Norway rat) | Ki | 8.9125 | 1 | 1 |
| sb-649915 | Rattus norvegicus (Norway rat) | Ki | 0.0035 | 4 | 4 |
| methyl 4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylate | Rattus norvegicus (Norway rat) | IC50 | 8.4900 | 1 | 1 |
| methyl 4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylate | Rattus norvegicus (Norway rat) | Ki | 8.4900 | 2 | 3 |
| kaspar | Rattus norvegicus (Norway rat) | IC50 | 0.1120 | 1 | 1 |
| 3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile | Rattus norvegicus (Norway rat) | Ki | 0.0011 | 1 | 1 |
| milnacipran | Rattus norvegicus (Norway rat) | IC50 | 0.1250 | 2 | 2 |
| milnacipran | Rattus norvegicus (Norway rat) | Ki | 0.0270 | 1 | 1 |
| 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 3 | 4 |
| gdc 0449 | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
| (1R,3S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylic acid methyl ester | Rattus norvegicus (Norway rat) | IC50 | 0.0042 | 2 | 4 |
| (1R,3S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylic acid methyl ester | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 2 |
| win 35,065-2 | Rattus norvegicus (Norway rat) | IC50 | 1.9990 | 1 | 2 |
| pf-03882845 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| n,n-diallyl-5-methoxytryptamine | Rattus norvegicus (Norway rat) | Ki | 5.1510 | 1 | 2 |
| clozapine | Rattus norvegicus (Norway rat) | Ki | 0.0210 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| cocaine | Rattus norvegicus (Norway rat) | Km | 0.2000 | 1 | 1 |
| n,n-dimethylepinephrine | Rattus norvegicus (Norway rat) | Km | 150.0000 | 1 | 1 |
| l 701324 | Rattus norvegicus (Norway rat) | Kb | 0.0280 | 1 | 1 |
| mdl 104653 | Rattus norvegicus (Norway rat) | Kb | 0.8800 | 1 | 1 |
Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.Journal of medicinal chemistry, , May-22, Volume: 51, Issue:10, 2008
Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor.Bioorganic & medicinal chemistry, , Dec-15, Volume: 21, Issue:24, 2013
Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents.European journal of medicinal chemistry, , Volume: 44, Issue:12, 2009
3-Phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake.Journal of medicinal chemistry, , Volume: 28, Issue:12, 1985
Synthesis and pharmacological evaluation of (Z)-9-(heteroarylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes: thiophene analogues as potent norepinephrine transporter inhibitors.Bioorganic & medicinal chemistry letters, , Oct-20, Volume: 13, Issue:20, 2003
9-Amino-1,2,3,4-tetrahydroacridin-1-ols: synthesis and evaluation as potential Alzheimer's disease therapeutics.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms.Journal of medicinal chemistry, , 10-24, Volume: 62, Issue:20, 2019
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.Journal of medicinal chemistry, , Aug-13, Volume: 52, Issue:15, 2009
Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.Bioorganic & medicinal chemistry, , Jul-15, Volume: 16, Issue:14, 2008
Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2.Journal of medicinal chemistry, , Nov-13, Volume: 51, Issue:21, 2008
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2'-Substituted 6-nitroquipazines.Bioorganic & medicinal chemistry, , May-15, Volume: 15, Issue:10, 2007
Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 17, Issue:3, 2007
Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 17, Issue:17, 2007
Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.Bioorganic & medicinal chemistry letters, , May-01, Volume: 17, Issue:9, 2007
Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 17, Issue:4, 2007
Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity.Journal of medicinal chemistry, , Jul-27, Volume: 49, Issue:15, 2006
Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.Journal of medicinal chemistry, , Jul-15, Volume: 47, Issue:15, 2004
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines.Bioorganic & medicinal chemistry letters, , Mar-11, Volume: 12, Issue:5, 2002
Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties.Journal of medicinal chemistry, , Mar-01, Volume: 44, Issue:5, 2001
New indole derivatives as potent and selective serotonin uptake inhibitors.Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: role of amino, fluoro, hydroxyl, methoxyl, methyl, mJournal of medicinal chemistry, , May-08, Volume: 51, Issue:9, 2008
Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter.Bioorganic & medicinal chemistry letters, , Apr-07, Volume: 13, Issue:7, 2003
Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine.Journal of medicinal chemistry, , Apr-10, Volume: 46, Issue:8, 2003
Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-pheJournal of medicinal chemistry, , Mar-14, Volume: 45, Issue:6, 2002
[3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter.Bioorganic & medicinal chemistry letters, , Dec-17, Volume: 11, Issue:24, 2001
Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues.Journal of medicinal chemistry, , Nov-08, Volume: 44, Issue:23, 2001
Synthesis and transporter binding properties of bridged piperazine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909).Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.Journal of medicinal chemistry, , Oct-21, Volume: 42, Issue:21, 1999
Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents.Journal of medicinal chemistry, , Dec-02, Volume: 42, Issue:24, 1999
Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors.Journal of medicinal chemistry, , Feb-28, Volume: 40, Issue:5, 1997
Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity.Journal of medicinal chemistry, , Jan-03, Volume: 40, Issue:1, 1997
Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).Journal of medicinal chemistry, , Nov-22, Volume: 39, Issue:24, 1996
N-substituted analogs of 2 beta-carbomethoxy-3 beta- (4'-iodophenyl)tropane (beta-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: role of amino, fluoro, hydroxyl, methoxyl, methyl, mJournal of medicinal chemistry, , May-08, Volume: 51, Issue:9, 2008
Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter.Bioorganic & medicinal chemistry letters, , Apr-07, Volume: 13, Issue:7, 2003
Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-pheJournal of medicinal chemistry, , Mar-14, Volume: 45, Issue:6, 2002
Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues.Journal of medicinal chemistry, , Nov-08, Volume: 44, Issue:23, 2001
Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents.Journal of medicinal chemistry, , Dec-02, Volume: 42, Issue:24, 1999
Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors.Journal of medicinal chemistry, , Feb-28, Volume: 40, Issue:5, 1997
Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).Journal of medicinal chemistry, , Nov-22, Volume: 39, Issue:24, 1996
Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HTEuropean journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HTEuropean journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins.Journal of medicinal chemistry, , Volume: 27, Issue:11, 1984
Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter.Journal of medicinal chemistry, , Dec-06, Volume: 39, Issue:25, 1996
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Structure-activity relationships for a series of (Bis(4-fluorophenyl)methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the dopamine transporter: Bioisosteric replacement of the piperazine improves metabolic stability.European journal of medicinal chemistry, , Dec-15, Volume: 208, 2020
Wake-promoting agents: search for next generation modafinil: part I.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
Wake-promoting agents: search for next generation modafinil: part IV.European journal of medicinal chemistry, , Volume: 54, 2012
Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography.Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.Journal of medicinal chemistry, , Feb-26, Volume: 41, Issue:5, 1998
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2'-Substituted 6-nitroquipazines.Bioorganic & medicinal chemistry, , May-15, Volume: 15, Issue:10, 2007
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines.Bioorganic & medicinal chemistry letters, , Mar-11, Volume: 12, Issue:5, 2002
Serotonin transporter inhibitors: synthesis and binding potency of 2'-methyl- and 3'-methyl-6-nitroquipazine.Bioorganic & medicinal chemistry letters, , Dec-04, Volume: 10, Issue:23, 2000
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.Journal of medicinal chemistry, , Feb-26, Volume: 41, Issue:5, 1998
Discovery of a potent, dual serotonin and norepinephrine reuptake inhibitor.ACS medicinal chemistry letters, , Jun-13, Volume: 4, Issue:6, 2013
Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010
Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.Journal of medicinal chemistry, , Jul-10, Volume: 51, Issue:13, 2008
Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.Journal of medicinal chemistry, , May-22, Volume: 51, Issue:10, 2008
Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.Journal of medicinal chemistry, , Jul-15, Volume: 47, Issue:15, 2004
Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands.Bioorganic & medicinal chemistry, , Dec-01, Volume: 18, Issue:23, 2010
Synthesis and biological evaluation of meperidine analogues at monoamine transporters.Journal of medicinal chemistry, , Mar-10, Volume: 48, Issue:5, 2005
Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy.Journal of medicinal chemistry, , Aug-26, Volume: 53, Issue:16, 2010
Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram.RSC medicinal chemistry, , Jul-21, Volume: 12, Issue:7, 2021
3-Phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake.Journal of medicinal chemistry, , Volume: 28, Issue:12, 1985
Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines.Bioorganic & medicinal chemistry letters, , Mar-11, Volume: 12, Issue:5, 2002
Synthesis and ligand binding of tropane ring analogues of paroxetine.Journal of medicinal chemistry, , Jan-15, Volume: 41, Issue:2, 1998
Synthesis of 2 beta-acyl-3 beta-aryl-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites in rat striatum and frontal cortex.Journal of medicinal chemistry, , Apr-29, Volume: 37, Issue:9, 1994
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995
[3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter.Bioorganic & medicinal chemistry letters, , Dec-17, Volume: 11, Issue:24, 2001
Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.Journal of medicinal chemistry, , Oct-21, Volume: 42, Issue:21, 1999
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins.Journal of medicinal chemistry, , Volume: 27, Issue:11, 1984
Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy.Journal of medicinal chemistry, , Aug-26, Volume: 53, Issue:16, 2010
Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes.Journal of medicinal chemistry, , Jul-26, Volume: 50, Issue:15, 2007
Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter.The Journal of biological chemistry, , Oct-05, Volume: 282, Issue:40, 2007
Development of peptidic dopamine transporter inhibitors via aromatic modification-mediated conformational restriction.Journal of medicinal chemistry, , Jul-13, Volume: 49, Issue:14, 2006
Synthesis and monoamine transporter binding properties of 3alpha-(substituted phenyl)nortropane-2beta-carboxylic acid methyl esters. Norepinephrine transporter selective compounds.Journal of medicinal chemistry, , Jun-02, Volume: 48, Issue:11, 2005
Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes.Journal of medicinal chemistry, , Jan-15, Volume: 47, Issue:2, 2004
Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
Synthesis and pharmacological evaluation of (Z)-9-(heteroarylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes: thiophene analogues as potent norepinephrine transporter inhibitors.Bioorganic & medicinal chemistry letters, , Oct-20, Volume: 13, Issue:20, 2003
Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites.Journal of medicinal chemistry, , May-08, Volume: 46, Issue:10, 2003
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.Journal of medicinal chemistry, , May-08, Volume: 46, Issue:10, 2003
Synthesis and pharmacology of site specific cocaine abuse treatment agents: 8-substituted isotropane (3-azabicyclo[3.2.1]octane) dopamine uptake inhibitors.Journal of medicinal chemistry, , Apr-10, Volume: 46, Issue:8, 2003
Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors.Bioorganic & medicinal chemistry letters, , Apr-08, Volume: 12, Issue:7, 2002
Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines.Bioorganic & medicinal chemistry letters, , Aug-19, Volume: 12, Issue:16, 2002
SAR studies of piperidine-based analogues of cocaine. 4. Effect of N-modification and ester replacement.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles.Bioorganic & medicinal chemistry letters, , Aug-20, Volume: 11, Issue:16, 2001
Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors.Bioorganic & medicinal chemistry letters, , May-07, Volume: 11, Issue:9, 2001
Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter.Journal of medicinal chemistry, , May-18, Volume: 43, Issue:10, 2000
Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationshiJournal of medicinal chemistry, , Feb-10, Volume: 43, Issue:3, 2000
3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter.Bioorganic & medicinal chemistry letters, , Nov-06, Volume: 10, Issue:21, 2000
Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.Journal of medicinal chemistry, , Oct-21, Volume: 42, Issue:21, 1999
N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 9, Issue:23, 1999
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-substituted-6-amino-5-phenylbicyclo[2.2.2]octanes.Journal of medicinal chemistry, , Nov-18, Volume: 42, Issue:23, 1999
Synthesis and transporter binding properties of (R)-2 beta, 3 beta- and (R)-2 alpha, 3 alpha-diaryltropanes.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 8, Issue:24, 1998
Synthesis and transporter binding properties of 2,3-diphenyltropane stereoisomers. Comparison to 3beta-phenyltropane-2beta-carboxylic acid esters.Journal of medicinal chemistry, , Apr-11, Volume: 40, Issue:8, 1997
Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).Journal of medicinal chemistry, , Nov-22, Volume: 39, Issue:24, 1996
3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
N-substituted analogs of 2 beta-carbomethoxy-3 beta- (4'-iodophenyl)tropane (beta-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter.Journal of medicinal chemistry, , Jan-20, Volume: 38, Issue:2, 1995
Synthesis and ligand binding study of 3 beta-(4'-substituted phenyl)-2 beta-(heterocyclic)tropanes.Journal of medicinal chemistry, , Sep-01, Volume: 38, Issue:18, 1995
Secondary amine analogues of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters.Journal of medicinal chemistry, , Apr-15, Volume: 37, Issue:8, 1994
Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.Journal of medicinal chemistry, , Jun-26, Volume: 35, Issue:13, 1992
[123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane: high-affinity SPECT radiotracer of monoamine reuptake sites in brain.Journal of medicinal chemistry, , Volume: 34, Issue:10, 1991
Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships.Journal of medicinal chemistry, , 12-08, Volume: 59, Issue:23, 2016
Discovery of triazines as potent, selective and orally active PDE4 inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013
Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography.Journal of medicinal chemistry, , Mar-13, Volume: 46, Issue:6, 2003
Synthesis and biological activity of conformationally restricted analogues of milnacipran: (1S, 2R)-1-phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide is a novel class of NMDA receptor channel blocker.Journal of medicinal chemistry, , Aug-27, Volume: 41, Issue:18, 1998
Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxami de, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist.Journal of medicinal chemistry, , Nov-22, Volume: 39, Issue:24, 1996
Synthesis and antidepressant activity of novel 1-(1-benzoylpiperidin-4-yl) methanamine derivatives selectively targeting SSRI/5-HTBioorganic & medicinal chemistry letters, , 11-15, Volume: 76, 2022
Synthesis and biological evaluation of 1-(4-(piperazin-1-yl)phenyl)pyridin-2(1H)-one derivatives as potential SSRIs.European journal of medicinal chemistry, , Nov-05, Volume: 223, 2021
[no title available]Bioorganic & medicinal chemistry letters, , 12-01, Volume: 29, Issue:23, 2019
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.Journal of medicinal chemistry, , 07-26, Volume: 61, Issue:14, 2018
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010
New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine).Journal of medicinal chemistry, , Oct-10, Volume: 45, Issue:21, 2002
A new single-photon emission computed tomography imaging agent for serotonin transporters: [123I]IDAM, 5-iodo-2-((2-((dimethylamino)methyl)phenyl)thio)benzyl alcohol.Journal of medicinal chemistry, , Feb-11, Volume: 42, Issue:3, 1999
[no title available]Bioorganic & medicinal chemistry letters, , 12-01, Volume: 29, Issue:23, 2019
[no title available]Bioorganic & medicinal chemistry letters, , 12-15, Volume: 29, Issue:24, 2019
Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.Journal of medicinal chemistry, , Mar-14, Volume: 45, Issue:6, 2002
New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine).Journal of medicinal chemistry, , Oct-10, Volume: 45, Issue:21, 2002
Novel 5-HT(1A/1B/1D) receptors antagonists with potent 5-HT reuptake inhibitory activity.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 18, Issue:20, 2008
Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.Journal of medicinal chemistry, , May-22, Volume: 51, Issue:10, 2008
3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 17, Issue:4, 2007
3,4-Dihydro-2H-benzoxazinones are 5-HT(1A) receptor antagonists with potent 5-HT reuptake inhibitory activity.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges.Journal of medicinal chemistry, , 03-22, Volume: 61, Issue:6, 2018
SAR studies of piperidine-based analogues of cocaine. 4. Effect of N-modification and ester replacement.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles.Bioorganic & medicinal chemistry letters, , Aug-20, Volume: 11, Issue:16, 2001
Discovery of a potent, dual serotonin and norepinephrine reuptake inhibitor.ACS medicinal chemistry letters, , Jun-13, Volume: 4, Issue:6, 2013
Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain.Journal of medicinal chemistry, , Nov-27, Volume: 51, Issue:22, 2008
Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.Journal of medicinal chemistry, , Mar-14, Volume: 45, Issue:6, 2002
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines.Bioorganic & medicinal chemistry letters, , Mar-11, Volume: 12, Issue:5, 2002
New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine).Journal of medicinal chemistry, , Oct-10, Volume: 45, Issue:21, 2002
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.Journal of medicinal chemistry, , May-08, Volume: 46, Issue:10, 2003
Secondary amine analogues of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters.Journal of medicinal chemistry, , Apr-15, Volume: 37, Issue:8, 1994
Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy.Journal of medicinal chemistry, , Aug-26, Volume: 53, Issue:16, 2010