Proteins > 5-hydroxytryptamine receptor 1B
Page last updated: 2024-08-07 16:21:21
5-hydroxytryptamine receptor 1B
A 5-hydroxytryptamine receptor 1B that is encoded in the genome of rat. [OMA:P28564, PRO:DNx]
Synonyms
5-HT-1B;
5-HT1B;
Serotonin receptor 1B
Research
Bioassay Publications (52)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 16 (30.77) | 18.7374 |
| 1990's | 25 (48.08) | 18.2507 |
| 2000's | 8 (15.38) | 29.6817 |
| 2010's | 3 (5.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (176)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tryptamine | Rattus norvegicus (Norway rat) | Ki | 10.2000 | 1 | 1 |
| 8-hydroxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | Ki | 18.9325 | 4 | 4 |
| 1-(1-naphthyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| 1-(2-methoxyphenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.0232 | 2 | 2 |
| 1-(3-chlorophenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.0348 | 3 | 3 |
| 2-methyl-5-ht | Rattus norvegicus (Norway rat) | Ki | 0.5200 | 1 | 1 |
| 3-nitrobenzeneboronic acid | Rattus norvegicus (Norway rat) | IC50 | 200.0000 | 1 | 1 |
| 5-carboxamidotryptamine | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| methylbufotenin | Rattus norvegicus (Norway rat) | Ki | 0.1633 | 3 | 3 |
| 5-methoxytryptamine | Rattus norvegicus (Norway rat) | Ki | 0.2015 | 3 | 4 |
| alpha-methylserotonin | Rattus norvegicus (Norway rat) | Ki | 0.5425 | 2 | 2 |
| amitriptyline | Rattus norvegicus (Norway rat) | IC50 | 1.0200 | 2 | 1 |
| amitriptyline | Rattus norvegicus (Norway rat) | Ki | 1.1410 | 1 | 0 |
| astemizole | Rattus norvegicus (Norway rat) | IC50 | 0.7670 | 1 | 0 |
| astemizole | Rattus norvegicus (Norway rat) | Ki | 0.4380 | 1 | 0 |
| benzo(b)thiophene-2-boronic acid | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| bithionol | Rattus norvegicus (Norway rat) | IC50 | 5.5150 | 1 | 0 |
| bithionol | Rattus norvegicus (Norway rat) | Ki | 3.1520 | 1 | 0 |
| bmy 7378 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| brimonidine | Rattus norvegicus (Norway rat) | IC50 | 2.5510 | 1 | 0 |
| brimonidine | Rattus norvegicus (Norway rat) | Ki | 1.4580 | 1 | 0 |
| buspirone | Rattus norvegicus (Norway rat) | IC50 | 9.0053 | 3 | 2 |
| buspirone | Rattus norvegicus (Norway rat) | Ki | 0.0132 | 2 | 1 |
| verapamil | Rattus norvegicus (Norway rat) | IC50 | 3.0200 | 1 | 0 |
| verapamil | Rattus norvegicus (Norway rat) | Ki | 1.7260 | 1 | 0 |
| carvedilol | Rattus norvegicus (Norway rat) | IC50 | 0.0058 | 1 | 0 |
| carvedilol | Rattus norvegicus (Norway rat) | Ki | 0.0033 | 1 | 0 |
| cgs 12066 | Rattus norvegicus (Norway rat) | IC50 | 0.2759 | 3 | 3 |
| chlorpromazine | Rattus norvegicus (Norway rat) | IC50 | 4.6850 | 1 | 0 |
| chlorpromazine | Rattus norvegicus (Norway rat) | Ki | 2.6770 | 1 | 0 |
| cisapride | Rattus norvegicus (Norway rat) | IC50 | 3.6495 | 2 | 1 |
| cisapride | Rattus norvegicus (Norway rat) | Ki | 5.8085 | 2 | 1 |
| clenbuterol | Rattus norvegicus (Norway rat) | IC50 | 2.6520 | 1 | 0 |
| clenbuterol | Rattus norvegicus (Norway rat) | Ki | 1.5150 | 1 | 0 |
| clomipramine | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 1 | 1 |
| clomipramine | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| clonidine | Rattus norvegicus (Norway rat) | IC50 | 5.3650 | 1 | 0 |
| clonidine | Rattus norvegicus (Norway rat) | Ki | 3.0660 | 1 | 0 |
| clotrimazole | Rattus norvegicus (Norway rat) | IC50 | 17.6880 | 1 | 0 |
| clotrimazole | Rattus norvegicus (Norway rat) | Ki | 10.1080 | 1 | 0 |
| cyproheptadine | Rattus norvegicus (Norway rat) | IC50 | 0.1220 | 1 | 0 |
| cyproheptadine | Rattus norvegicus (Norway rat) | Ki | 0.0700 | 1 | 0 |
| desipramine | Rattus norvegicus (Norway rat) | IC50 | 0.3500 | 1 | 1 |
| amphetamine | Rattus norvegicus (Norway rat) | Ki | 7.6600 | 1 | 1 |
| doxepin | Rattus norvegicus (Norway rat) | IC50 | 0.8595 | 2 | 1 |
| doxepin | Rattus norvegicus (Norway rat) | Ki | 0.8680 | 1 | 0 |
| droperidol | Rattus norvegicus (Norway rat) | IC50 | 0.2420 | 1 | 0 |
| droperidol | Rattus norvegicus (Norway rat) | Ki | 0.1380 | 1 | 0 |
| econazole | Rattus norvegicus (Norway rat) | IC50 | 16.1770 | 1 | 0 |
| econazole | Rattus norvegicus (Norway rat) | Ki | 9.2440 | 1 | 0 |
| fluphenazine | Rattus norvegicus (Norway rat) | IC50 | 1.6440 | 1 | 0 |
| fluphenazine | Rattus norvegicus (Norway rat) | Ki | 0.9390 | 1 | 0 |
| granisetron | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| haloperidol | Rattus norvegicus (Norway rat) | IC50 | 0.5090 | 2 | 2 |
| imipramine | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| ketanserin | Rattus norvegicus (Norway rat) | Ki | 1.9000 | 1 | 1 |
| ketotifen | Rattus norvegicus (Norway rat) | IC50 | 2.5370 | 1 | 0 |
| ketotifen | Rattus norvegicus (Norway rat) | Ki | 1.4500 | 1 | 0 |
| labetalol | Rattus norvegicus (Norway rat) | IC50 | 0.3930 | 1 | 0 |
| labetalol | Rattus norvegicus (Norway rat) | Ki | 0.2250 | 1 | 0 |
| metoclopramide | Rattus norvegicus (Norway rat) | IC50 | 7.8000 | 1 | 1 |
| mianserin | Rattus norvegicus (Norway rat) | IC50 | 2.9360 | 2 | 1 |
| mianserin | Rattus norvegicus (Norway rat) | Ki | 1.7195 | 4 | 3 |
| miconazole | Rattus norvegicus (Norway rat) | IC50 | 11.4720 | 1 | 0 |
| miconazole | Rattus norvegicus (Norway rat) | Ki | 6.5550 | 1 | 0 |
| 1-(3-trifluoromethylphenyl)piperazine | Rattus norvegicus (Norway rat) | IC50 | 0.0390 | 2 | 2 |
| 1-(3-trifluoromethylphenyl)piperazine | Rattus norvegicus (Norway rat) | Ki | 0.0180 | 4 | 4 |
| nan 190 | Rattus norvegicus (Norway rat) | Ki | 1.0715 | 1 | 1 |
| nomifensine | Rattus norvegicus (Norway rat) | Ki | 0.0260 | 1 | 1 |
| nortriptyline | Rattus norvegicus (Norway rat) | IC50 | 1.0190 | 2 | 1 |
| nortriptyline | Rattus norvegicus (Norway rat) | Ki | 1.0680 | 1 | 0 |
| ondansetron | Rattus norvegicus (Norway rat) | Ki | 6.8500 | 2 | 2 |
| oxymetazoline | Rattus norvegicus (Norway rat) | IC50 | 0.0056 | 1 | 0 |
| oxymetazoline | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 0 |
| moxonidine | Rattus norvegicus (Norway rat) | IC50 | 0.7021 | 1 | 0 |
| moxonidine | Rattus norvegicus (Norway rat) | Ki | 0.4012 | 1 | 0 |
| pindolol | Rattus norvegicus (Norway rat) | IC50 | 0.0480 | 1 | 0 |
| pindolol | Rattus norvegicus (Norway rat) | Ki | 0.0690 | 3 | 2 |
| pirenperone | Rattus norvegicus (Norway rat) | Ki | 6.6000 | 1 | 1 |
| prazosin | Rattus norvegicus (Norway rat) | Ki | 0.0010 | 1 | 1 |
| prochlorperazine | Rattus norvegicus (Norway rat) | IC50 | 0.9500 | 1 | 0 |
| prochlorperazine | Rattus norvegicus (Norway rat) | Ki | 0.5430 | 1 | 0 |
| promazine | Rattus norvegicus (Norway rat) | IC50 | 5.1720 | 1 | 0 |
| promazine | Rattus norvegicus (Norway rat) | Ki | 2.9550 | 1 | 0 |
| promethazine | Rattus norvegicus (Norway rat) | IC50 | 2.5960 | 1 | 0 |
| promethazine | Rattus norvegicus (Norway rat) | Ki | 1.4840 | 1 | 0 |
| propafenone | Rattus norvegicus (Norway rat) | IC50 | 1.6370 | 1 | 0 |
| propafenone | Rattus norvegicus (Norway rat) | Ki | 0.9350 | 1 | 0 |
| propranolol | Rattus norvegicus (Norway rat) | IC50 | 0.2430 | 1 | 0 |
| propranolol | Rattus norvegicus (Norway rat) | Ki | 0.0945 | 2 | 1 |
| quetiapine | Rattus norvegicus (Norway rat) | IC50 | 1.4264 | 1 | 0 |
| quetiapine | Rattus norvegicus (Norway rat) | Ki | 0.8151 | 1 | 0 |
| quipazine | Rattus norvegicus (Norway rat) | IC50 | 3.7297 | 3 | 4 |
| quipazine | Rattus norvegicus (Norway rat) | Ki | 0.1739 | 5 | 6 |
| risperidone | Rattus norvegicus (Norway rat) | IC50 | 0.7990 | 1 | 0 |
| risperidone | Rattus norvegicus (Norway rat) | Ki | 0.4570 | 1 | 0 |
| spiperone | Rattus norvegicus (Norway rat) | Ki | 2.4800 | 2 | 2 |
| spiroxatrine | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| sumatriptan | Rattus norvegicus (Norway rat) | IC50 | 0.8040 | 1 | 0 |
| sumatriptan | Rattus norvegicus (Norway rat) | Ki | 0.4590 | 1 | 0 |
| thioridazine | Rattus norvegicus (Norway rat) | IC50 | 0.0600 | 1 | 0 |
| thioridazine | Rattus norvegicus (Norway rat) | Ki | 0.0340 | 1 | 0 |
| trazodone | Rattus norvegicus (Norway rat) | IC50 | 0.3110 | 1 | 0 |
| trazodone | Rattus norvegicus (Norway rat) | Ki | 0.1780 | 1 | 0 |
| apomorphine | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| medroxyprogesterone acetate | Rattus norvegicus (Norway rat) | IC50 | 1.1970 | 1 | 1 |
| phenylpiperazine | Rattus norvegicus (Norway rat) | Ki | 0.1158 | 3 | 3 |
| ergotamine | Rattus norvegicus (Norway rat) | IC50 | 0.0008 | 1 | 0 |
| ergotamine | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 0 |
| methylergonovine | Rattus norvegicus (Norway rat) | IC50 | 0.0041 | 1 | 0 |
| methylergonovine | Rattus norvegicus (Norway rat) | Ki | 0.0023 | 1 | 0 |
| 3,4-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 64.6000 | 1 | 1 |
| dibenzothiazyl disulfide | Rattus norvegicus (Norway rat) | IC50 | 0.7470 | 1 | 0 |
| dibenzothiazyl disulfide | Rattus norvegicus (Norway rat) | Ki | 0.4270 | 1 | 0 |
| sterogenol | Rattus norvegicus (Norway rat) | IC50 | 2.8310 | 1 | 0 |
| sterogenol | Rattus norvegicus (Norway rat) | Ki | 1.6180 | 1 | 0 |
| yohimbine | Rattus norvegicus (Norway rat) | IC50 | 0.1260 | 1 | 0 |
| yohimbine | Rattus norvegicus (Norway rat) | Ki | 0.0720 | 1 | 0 |
| methysergide | Rattus norvegicus (Norway rat) | IC50 | 0.0540 | 1 | 0 |
| methysergide | Rattus norvegicus (Norway rat) | Ki | 0.0310 | 1 | 0 |
| bufotenin | Rattus norvegicus (Norway rat) | Ki | 0.9100 | 1 | 1 |
| dihydroergotamine | Rattus norvegicus (Norway rat) | IC50 | 0.0007 | 1 | 0 |
| dihydroergotamine | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 0 |
| lysergol | Rattus norvegicus (Norway rat) | IC50 | 0.0150 | 1 | 1 |
| dexpropranolol | Rattus norvegicus (Norway rat) | IC50 | 4.8800 | 1 | 0 |
| dexpropranolol | Rattus norvegicus (Norway rat) | Ki | 2.7890 | 1 | 0 |
| 2,5-dimethoxy-4-ethylamphetamine | Rattus norvegicus (Norway rat) | Ki | 4.5700 | 1 | 1 |
| metergoline | Rattus norvegicus (Norway rat) | IC50 | 0.0062 | 1 | 0 |
| metergoline | Rattus norvegicus (Norway rat) | Ki | 0.0162 | 3 | 2 |
| lisuride | Rattus norvegicus (Norway rat) | IC50 | 0.0005 | 1 | 0 |
| lisuride | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 0 |
| 2,4,5-trimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Ki | 46.4000 | 1 | 1 |
| bromocriptine | Rattus norvegicus (Norway rat) | IC50 | 0.0056 | 1 | 0 |
| bromocriptine | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 0 |
| 4-methoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 79.4000 | 1 | 1 |
| timolol | Rattus norvegicus (Norway rat) | IC50 | 2.7120 | 1 | 0 |
| timolol | Rattus norvegicus (Norway rat) | Ki | 1.5500 | 1 | 0 |
| levobunolol | Rattus norvegicus (Norway rat) | IC50 | 2.9010 | 1 | 0 |
| levobunolol | Rattus norvegicus (Norway rat) | Ki | 1.6580 | 1 | 0 |
| bopindolol | Rattus norvegicus (Norway rat) | IC50 | 0.2670 | 1 | 0 |
| bopindolol | Rattus norvegicus (Norway rat) | Ki | 0.1530 | 1 | 0 |
| indalpine | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 2 |
| pergolide | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 2 | 1 |
| pergolide | Rattus norvegicus (Norway rat) | Ki | 0.0085 | 1 | 0 |
| quinpirole | Rattus norvegicus (Norway rat) | Ki | 1.5000 | 1 | 1 |
| ipsapirone | Rattus norvegicus (Norway rat) | IC50 | 38.0000 | 2 | 2 |
| 2,5-dimethoxy-4-bromoamphetamine | Rattus norvegicus (Norway rat) | Ki | 3.3400 | 1 | 1 |
| 2,5-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 1.0200 | 1 | 1 |
| eltoprazine | Rattus norvegicus (Norway rat) | Ki | 0.0537 | 1 | 1 |
| dexfenfluramine | Rattus norvegicus (Norway rat) | IC50 | 3.4030 | 1 | 0 |
| dexfenfluramine | Rattus norvegicus (Norway rat) | Ki | 1.9440 | 1 | 0 |
| methyl 2-tetradecylglycidate | Rattus norvegicus (Norway rat) | IC50 | 0.3000 | 1 | 1 |
| etisulergine | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 2 | 2 |
| mesulergine | Rattus norvegicus (Norway rat) | Ki | 13.0000 | 1 | 1 |
| 2-tetradecylglycidic acid | Rattus norvegicus (Norway rat) | IC50 | 0.9000 | 1 | 1 |
| carbobenzoxyvalylphenylalanine aldehyde | Rattus norvegicus (Norway rat) | IC50 | 0.3000 | 1 | 1 |
| ergocornine | Rattus norvegicus (Norway rat) | IC50 | 0.0031 | 1 | 0 |
| ergocornine | Rattus norvegicus (Norway rat) | Ki | 0.0018 | 1 | 0 |
| agroclavine | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| 2,5-dimethoxy-4-methylamphetamine | Rattus norvegicus (Norway rat) | Ki | 2.8900 | 1 | 1 |
| 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane | Rattus norvegicus (Norway rat) | Ki | 14.1000 | 1 | 1 |
| 6-chloro-2-(1-piperazinyl)pyrazine | Rattus norvegicus (Norway rat) | Ki | 0.5110 | 2 | 2 |
| 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole | Rattus norvegicus (Norway rat) | IC50 | 0.0040 | 2 | 2 |
| 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole | Rattus norvegicus (Norway rat) | Ki | 0.0030 | 2 | 2 |
| alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol | Rattus norvegicus (Norway rat) | IC50 | 1.5000 | 1 | 1 |
| mosapride | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| cp 93129 | Rattus norvegicus (Norway rat) | IC50 | 0.0150 | 1 | 1 |
| l 687384 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| mcn 5707 | Rattus norvegicus (Norway rat) | Ki | 4.5267 | 1 | 3 |
| vb 20b7 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| sc 53116 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 2 |
| 4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine | Rattus norvegicus (Norway rat) | Ki | 1.7783 | 1 | 1 |
| alpha-ergocryptine | Rattus norvegicus (Norway rat) | IC50 | 0.0026 | 1 | 0 |
| alpha-ergocryptine | Rattus norvegicus (Norway rat) | Ki | 0.0015 | 1 | 0 |
| n-dansyl-3-aminobenzeneboronic acid | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| n-methylserotonin | Rattus norvegicus (Norway rat) | Ki | 0.0450 | 1 | 1 |
| 3-methoxyamphetamine | Rattus norvegicus (Norway rat) | Ki | 2.6600 | 1 | 1 |
| n-desmethylmethoxyphenamine | Rattus norvegicus (Norway rat) | Ki | 3.5000 | 1 | 1 |
| 6-hydroxytryptamine | Rattus norvegicus (Norway rat) | Ki | 5.8900 | 1 | 1 |
| n,n-di-n-propylserotonin | Rattus norvegicus (Norway rat) | Ki | 4.3000 | 1 | 1 |
| 8-methoxy-2-(di-n-propylamino)tetralin | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 1 | 1 |
| maduramicin | Rattus norvegicus (Norway rat) | IC50 | 0.0078 | 1 | 0 |
| maduramicin | Rattus norvegicus (Norway rat) | Ki | 0.0045 | 1 | 0 |
| saquinavir | Rattus norvegicus (Norway rat) | IC50 | 4.2730 | 1 | 0 |
| saquinavir | Rattus norvegicus (Norway rat) | Ki | 2.4420 | 1 | 0 |
| ergonovine | Rattus norvegicus (Norway rat) | IC50 | 0.0081 | 1 | 0 |
| ergonovine | Rattus norvegicus (Norway rat) | Ki | 0.0046 | 1 | 0 |
| dihydroergocristine monomesylate | Rattus norvegicus (Norway rat) | IC50 | 0.0007 | 1 | 0 |
| dihydroergocristine monomesylate | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 0 |
| cocaine | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| (1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol | Rattus norvegicus (Norway rat) | IC50 | 0.5435 | 1 | 0 |
| (1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol | Rattus norvegicus (Norway rat) | Ki | 0.3106 | 1 | 0 |
| (S)-(-)-pindolol | Rattus norvegicus (Norway rat) | IC50 | 0.0280 | 1 | 0 |
| (S)-(-)-pindolol | Rattus norvegicus (Norway rat) | Ki | 0.0160 | 1 | 0 |
| flunarizine | Rattus norvegicus (Norway rat) | IC50 | 4.2810 | 1 | 0 |
| flunarizine | Rattus norvegicus (Norway rat) | Ki | 2.4460 | 1 | 0 |
| cinnarizine | Rattus norvegicus (Norway rat) | IC50 | 1.0830 | 1 | 0 |
| cinnarizine | Rattus norvegicus (Norway rat) | Ki | 0.6190 | 1 | 0 |
| tamoxifen | Rattus norvegicus (Norway rat) | IC50 | 12.1600 | 1 | 0 |
| tamoxifen | Rattus norvegicus (Norway rat) | Ki | 6.9490 | 1 | 0 |
| bms 387032 | Rattus norvegicus (Norway rat) | IC50 | 40.0000 | 1 | 1 |
| dapiprazole | Rattus norvegicus (Norway rat) | IC50 | 2.0600 | 1 | 0 |
| dapiprazole | Rattus norvegicus (Norway rat) | Ki | 1.1770 | 1 | 0 |
| mcn 5652 | Rattus norvegicus (Norway rat) | Ki | 0.9025 | 1 | 2 |
| 5-methoxy-3-(di-n-propylamino)chroman | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 1 |
| quinagolide | Rattus norvegicus (Norway rat) | IC50 | 5.6000 | 2 | 4 |
| 3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione | Rattus norvegicus (Norway rat) | Ki | 3,715,350,000,000,000.0000 | 1 | 1 |
| bw 723c86 | Rattus norvegicus (Norway rat) | IC50 | 1.1278 | 1 | 0 |
| bw 723c86 | Rattus norvegicus (Norway rat) | Ki | 0.6445 | 1 | 0 |
| sb 277011 | Rattus norvegicus (Norway rat) | Ki | 0.3981 | 1 | 1 |
| preclamol | Rattus norvegicus (Norway rat) | Ki | 2.1000 | 1 | 1 |
| oxiconazole | Rattus norvegicus (Norway rat) | IC50 | 5.5774 | 1 | 0 |
| oxiconazole | Rattus norvegicus (Norway rat) | Ki | 3.1871 | 1 | 0 |
| cinanserin | Rattus norvegicus (Norway rat) | Ki | 2.2500 | 2 | 2 |
| guanabenz | Rattus norvegicus (Norway rat) | IC50 | 2.0680 | 1 | 0 |
| guanabenz | Rattus norvegicus (Norway rat) | Ki | 1.1810 | 1 | 0 |
| cilansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 2 |
| vilazodone | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| 2-ethyl-5-methoxy-n,n-dimethyltryptamine | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 2.2950 | 1 | 2 |
| s 21007 | Rattus norvegicus (Norway rat) | IC50 | 1.0233 | 2 | 2 |
| 5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole | Rattus norvegicus (Norway rat) | IC50 | 0.1800 | 1 | 1 |
| 2,5-dimethoxy-4-methylamphetamine, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 3.5500 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine, (r)-isomer | Rattus norvegicus (Norway rat) | Ki | 4.2000 | 1 | 2 |
| 2,5-dimethoxy-4-bromoamphetamine, (s)-isomer | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| clozapine | Rattus norvegicus (Norway rat) | IC50 | 0.3730 | 3 | 2 |
| clozapine | Rattus norvegicus (Norway rat) | Ki | 0.1521 | 2 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| phenethylamine | Rattus norvegicus (Norway rat) | Kd | 5.4954 | 2 | 4 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.0324 | 1 | 1 |
| 3,4-methylenedioxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.3548 | 1 | 2 |
| cirazoline | Rattus norvegicus (Norway rat) | EC50 | 0.0126 | 1 | 1 |
| amphetamine | Rattus norvegicus (Norway rat) | Kd | 5.3703 | 3 | 5 |
| mescaline | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| naphazoline | Rattus norvegicus (Norway rat) | EC50 | 0.0631 | 1 | 1 |
| oxymetazoline | Rattus norvegicus (Norway rat) | EC50 | 0.0200 | 1 | 1 |
| o-methyltyramine | Rattus norvegicus (Norway rat) | Kd | 7.9433 | 1 | 2 |
| tyramine | Rattus norvegicus (Norway rat) | Kd | 8.5114 | 1 | 2 |
| dextroamphetamine | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| n,n-dimethyltryptamine | Rattus norvegicus (Norway rat) | Kd | 1.0000 | 1 | 1 |
| dimethoxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 4.3652 | 1 | 2 |
| 3,4-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 3.5481 | 1 | 2 |
| 3-phenylpropylamine | Rattus norvegicus (Norway rat) | Kd | 11.7490 | 1 | 2 |
| 2,5-dimethoxy-4-ethylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0661 | 2 | 3 |
| 2,4,5-trimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.1549 | 2 | 3 |
| 4-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 7.0795 | 2 | 3 |
| l-amphetamine | Rattus norvegicus (Norway rat) | Kd | 6.9183 | 1 | 2 |
| 2-aminotetralin | Rattus norvegicus (Norway rat) | Kd | 2.4547 | 1 | 2 |
| 2,5-dimethoxy-4-bromoamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0447 | 2 | 3 |
| cathinone | Rattus norvegicus (Norway rat) | Kd | 3.0200 | 1 | 2 |
| 2,5-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.1479 | 2 | 3 |
| 3,4-methylenedioxyphenethylamine | Rattus norvegicus (Norway rat) | Kd | 0.7943 | 1 | 2 |
| 3-methoxy-4-hydroxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 1.2882 | 1 | 2 |
| 2-(2,5-dimethoxyphenyl)ethanamine | Rattus norvegicus (Norway rat) | Kd | 0.1412 | 1 | 2 |
| 2,5-dimethoxy-4-methylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0753 | 2 | 3 |
| 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane | Rattus norvegicus (Norway rat) | Kd | 0.0851 | 1 | 1 |
| cp 93129 | Rattus norvegicus (Norway rat) | EC50 | 0.0560 | 1 | 1 |
| 3-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 1.1749 | 3 | 4 |
| n-desmethylmethoxyphenamine | Rattus norvegicus (Norway rat) | Kd | 2.8840 | 2 | 3 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.0234 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine, (s)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.1175 | 1 | 1 |
| vu0357017 | Rattus norvegicus (Norway rat) | EC50 | 95.7200 | 1 | 0 |
Drugs with Other Measurements
Structure-activity relationships in 1,4-benzodioxan-related compounds. 6. Role of the dioxane unit on selectivity for alpha(1)-adrenoreceptor subtypes.Journal of medicinal chemistry, , Jul-29, Volume: 42, Issue:15, 1999
Synthesis and structure activity relationships of cis- and trans-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridines for 5-HT receptor subtypes.Journal of medicinal chemistry, , Jan-07, Volume: 37, Issue:1, 1994
N,N-di-n-propylserotonin: binding at serotonin binding sites and a comparison with 8-hydroxy-2-(di-n-propylamino)tetralin.Journal of medicinal chemistry, , Volume: 31, Issue:4, 1988
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Synthesis and structure activity relationships of cis- and trans-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridines for 5-HT receptor subtypes.Journal of medicinal chemistry, , Jan-07, Volume: 37, Issue:1, 1994
(S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.Journal of medicinal chemistry, , May-14, Volume: 36, Issue:10, 1993
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
[no title available],
Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines.Journal of medicinal chemistry, , Jun-06, Volume: 40, Issue:12, 1997
Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines.Journal of medicinal chemistry, , May-10, Volume: 39, Issue:10, 1996
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.Journal of medicinal chemistry, , Apr-17, Volume: 35, Issue:8, 1992
Novel benzamides as selective and potent gastrokinetic agents. 2. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2- morpholinyl]methyl] benzamide citrate (AS-4370) and related compounds.Journal of medicinal chemistry, , Volume: 34, Issue:2, 1991
[no title available],
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Serotonin receptor affinity of cathinone and related analogues.Journal of medicinal chemistry, , Volume: 25, Issue:4, 1982
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles.Journal of medicinal chemistry, , May-26, Volume: 38, Issue:11, 1995
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 29, Issue:3, 1986
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.Journal of medicinal chemistry, , Volume: 30, Issue:8, 1987
[no title available],
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.Journal of medicinal chemistry, , Volume: 32, Issue:5, 1989
2H-[1]benzopyrano[3,4-b]pyridines: synthesis and activity at central monoamine receptors.Journal of medicinal chemistry, , Volume: 32, Issue:3, 1989
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.Journal of medicinal chemistry, , Oct-21, Volume: 42, Issue:21, 1999
Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines.Journal of medicinal chemistry, , Jun-06, Volume: 40, Issue:12, 1997
Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines.Journal of medicinal chemistry, , May-10, Volume: 39, Issue:10, 1996
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995
3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans].Journal of medicinal chemistry, , Oct-11, Volume: 39, Issue:21, 1996
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT(6) receptor agonists.European journal of medicinal chemistry, , Volume: 63, 2013
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Bridgehead-methyl analog of SC-53116 as a 5-HT4 agonist.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.Journal of medicinal chemistry, , Apr-17, Volume: 35, Issue:8, 1992
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Studies on several 7-substituted N,N-dimethyltryptamines.Journal of medicinal chemistry, , Volume: 23, Issue:11, 1980
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Central serotonin receptors as targets for drug research.Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines.Journal of medicinal chemistry, , Jun-06, Volume: 40, Issue:12, 1997
Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines.Journal of medicinal chemistry, , May-10, Volume: 39, Issue:10, 1996
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.Bioorganic & medicinal chemistry, , Apr-15, Volume: 24, Issue:8, 2016
N-aryl-N'-benzylpiperazines as potential antipsychotic agents.Journal of medicinal chemistry, , Oct-13, Volume: 38, Issue:21, 1995
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.Journal of medicinal chemistry, , Volume: 29, Issue:3, 1986
[no title available],