Solute carrier family 12 member 2

A solute carrier family 12 member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P55011]

Synonyms

Basolateral Na-K-Cl symporter;
Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (2)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bumetanide	Homo sapiens (human)	IC50	0.8000	1	0
n-(4-methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetamide	Homo sapiens (human)	IC50	50.0000	1	1

Enables

This protein enables 9 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
sodium:potassium:chloride symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in). [TC:2.A.30.1.1]
ammonium transmembrane transporter activity	molecular function	Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. [PMID:17710640]
potassium ion transmembrane transporter activity	molecular function	Enables the transfer of potassium ions (K+) from one side of a membrane to the other. [GOC:ai]
chloride:monoatomic cation symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). [PMID:31747317]
protein kinase binding	molecular function	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
metal ion transmembrane transporter activity	molecular function	Enables the transfer of metal ions from one side of a membrane to the other. [GOC:ai]
protein-folding chaperone binding	molecular function	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. [PMID:10585443]
Hsp90 protein binding	molecular function	Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. [GOC:ai]

Located In

This protein is located in 15 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
basal plasma membrane	cellular component	The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
lateral plasma membrane	cellular component	The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. [GOC:hb, GOC:mah, GOC:pr]
cytoplasmic vesicle membrane	cellular component	The lipid bilayer surrounding a cytoplasmic vesicle. [GOC:mah]
cell projection membrane	cellular component	The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. [GOC:krc, GOC:mah]
cell projection	cellular component	A prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
neuron projection	cellular component	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
cell body	cellular component	The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. [GOC:go_curators]
cell body membrane	cellular component	The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections. [GOC:ecd]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
cell periphery	cellular component	The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. [GOC:pdt]
extracellular vesicle	cellular component	Any vesicle that is part of the extracellular region. [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
basolateral plasma membrane	cellular component	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]

Involved In

This protein is involved in 20 target(s):

Target	Category	Definition
monoatomic ion transport	biological process	The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
cell volume homeostasis	biological process	Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. [GOC:dph, GOC:go_curators, GOC:tb]
hyperosmotic response	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. [GOC:jl, PMID:12142009]
T cell chemotaxis	biological process	The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. [GOC:dph, GOC:tb]
transepithelial chloride transport	biological process	The directed movement of chloride ions from one side of an epithelium to the other. [GOC:mah]
cellular response to potassium ion	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. [GOC:yaf]
positive regulation of cell volume	biological process	Any process that increases cell volume. [GOC:go_curators]
transepithelial ammonium transport	biological process	The directed movement of ammonium ions from one side of an epithelium to the other. [GOC:mah, GOC:yaf]
ammonium transmembrane transport	biological process	The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. [GOC:mah]
inorganic anion import across plasma membrane	biological process	The directed movement of inorganic anions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]
inorganic cation import across plasma membrane	biological process	The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]
sodium ion import across plasma membrane	biological process	The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]
transport across blood-brain barrier	biological process	The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008]
chloride transmembrane transport	biological process	The process in which chloride is transported across a membrane. [GOC:TermGenie, GOC:vw]
potassium ion import across plasma membrane	biological process	The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. [PMID:9139127]
cellular response to chemokine	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus. [PMID:11113082]
sodium ion homeostasis	biological process	Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell. [GOC:ai, GOC:jid, GOC:mah]
chloride ion homeostasis	biological process	Any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell. [GOC:jid, GOC:mah]
sodium ion transmembrane transport	biological process	A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw]
potassium ion homeostasis	biological process	Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell. [GOC:jid, GOC:mah]