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Coagulation factor X
A coagulation factor X that is encoded in the genome of rabbit. [OMA:O19045, PRO:DNx]
Synonyms
EC 3.4.21.6;
Stuart factor
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| dx 9065 | Oryctolagus cuniculus (rabbit) | IC50 | 0.0410 | 1 | 1 |
| razaxaban | Oryctolagus cuniculus (rabbit) | Ki | 0.0002 | 2 | 2 |
| bms 740808 | Oryctolagus cuniculus (rabbit) | Ki | 0.0001 | 1 | 1 |
| apixaban | Oryctolagus cuniculus (rabbit) | Ki | 0.0002 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| otamixaban | Oryctolagus cuniculus (rabbit) | Kd | 0.1049 | 1 | 0 |
Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation faJournal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation faJournal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation faJournal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007