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Prostaglandin G/H synthase 2
A prostaglandin G/H synthase 2 that is encoded in the genome of mouse. [OMA:Q05769, PRO:DNx]
Synonyms
EC 1.14.99.1;
Cyclooxygenase-2;
COX-2;
Glucocorticoid-regulated inflammatory cyclooxygenase;
Gripghs;
Macrophage activation-associated marker protein P71/73;
PES-2;
PHS II;
Prostaglandin H2 synthase 2;
PGH synthase 2;<
Research
Bioassay Publications (39)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (7.69) | 18.2507 |
| 2000's | 15 (38.46) | 29.6817 |
| 2010's | 18 (46.15) | 24.3611 |
| 2020's | 3 (7.69) | 2.80 |
Compounds (24)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| indomethacin | Mus musculus (house mouse) | Activity | 0.2500 | 1 | 1 |
Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties.European journal of medicinal chemistry, , Nov-05, Volume: 241, 2022
Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer.Journal of medicinal chemistry, , 08-12, Volume: 64, Issue:15, 2021
Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 24, Issue:8, 2014
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.Bioorganic & medicinal chemistry, , Jul-01, Volume: 21, Issue:13, 2013
Synthesis and biological evaluation of some novel resveratrol amide derivatives as potential anti-tumor agents.European journal of medicinal chemistry, , Volume: 62, 2013
Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.Journal of medicinal chemistry, , Nov-24, Volume: 54, Issue:22, 2011
[I]-Celecoxib Analogues as SPECT Tracers of Cyclooxygenase-2 in Inflammation.ACS medicinal chemistry letters, , Feb-10, Volume: 2, Issue:2, 2011
Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.Bioorganic & medicinal chemistry, , Sep-01, Volume: 16, Issue:17, 2008
Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity.Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Design, synthesis, and biological evaluation of substituted 2-alkylthio-1,5-diarylimidazoles as selective COX-2 inhibitors.Bioorganic & medicinal chemistry, , Mar-01, Volume: 15, Issue:5, 2007
Triterpene saponins from clematis mandshurica.Journal of natural products, , Volume: 69, Issue:11, 2006
1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: molecular docking and 3D QSAR analyses.Journal of medicinal chemistry, , Oct-24, Volume: 45, Issue:22, 2002
1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: a new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite.Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumiracoxib.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 23, Issue:21, 2013
Structural and functional basis of cyclooxygenase inhibition.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.The Journal of biological chemistry, , Jun-01, Volume: 282, Issue:22, 2007
Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 24, Issue:8, 2014
Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors.ACS chemical biology, , 11-18, Volume: 11, Issue:11, 2016
Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.Journal of medicinal chemistry, , Mar-28, Volume: 56, Issue:6, 2013
The 2'-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor.ACS medicinal chemistry letters, , May-09, Volume: 4, Issue:5, 2013
Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives for the treatment of inflammatory diseases.Journal of medicinal chemistry, , Apr-14, Volume: 54, Issue:7, 2011
In silico search for multi-target anti-inflammatories in Chinese herbs and formulas.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Podophyllotoxin analogues active versus Trypanosoma brucei.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 20, Issue:5, 2010
Structural and functional basis of cyclooxygenase inhibition.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
Enantiospecific, selective cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry letters, , May-06, Volume: 12, Issue:9, 2002
Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.Proceedings of the National Academy of Sciences of the United States of America, , Jan-18, Volume: 97, Issue:2, 2000
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.Journal of medicinal chemistry, , Apr-08, Volume: 42, Issue:7, 1999
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.Journal of medicinal chemistry, , Apr-08, Volume: 42, Issue:7, 1999
Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity.Journal of medicinal chemistry, , Jan-05, Volume: 39, Issue:1, 1996
Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry letters, , Feb-25, Volume: 12, Issue:4, 2002
Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.Proceedings of the National Academy of Sciences of the United States of America, , Jan-18, Volume: 97, Issue:2, 2000
Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.Bioorganic & medicinal chemistry, , Jan-15, Volume: 18, Issue:2, 2010
Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.Proceedings of the National Academy of Sciences of the United States of America, , Jan-18, Volume: 97, Issue:2, 2000
Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 24, Issue:8, 2014
Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.Bioorganic & medicinal chemistry, , Jan-15, Volume: 18, Issue:2, 2010
Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 19, Issue:6, 2009
Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities.Bioorganic & medicinal chemistry letters, , May-17, Volume: 14, Issue:10, 2004
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.Journal of medicinal chemistry, , Apr-08, Volume: 42, Issue:7, 1999
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.Journal of medicinal chemistry, , Apr-08, Volume: 42, Issue:7, 1999
Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.ACS medicinal chemistry letters, , Nov-13, Volume: 5, Issue:11, 2014
1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors.ACS chemical biology, , 11-18, Volume: 11, Issue:11, 2016
Podophyllotoxin analogues active versus Trypanosoma brucei.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 20, Issue:5, 2010
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.Journal of medicinal chemistry, , Apr-08, Volume: 42, Issue:7, 1999
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.Journal of medicinal chemistry, , Apr-08, Volume: 42, Issue:7, 1999
Synthetic approaches to the 2012 new drugs.Bioorganic & medicinal chemistry, , Apr-01, Volume: 22, Issue:7, 2014
Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 19, Issue:8, 2009