verapamil has been researched along with Necrosis in 73 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During this experiment the authors investigated whether prolonged local use of verapamil or lidocaine prevents vasoconstriction and establishes better blood supply to the rat epigastric skin flap, hence reducing the necrosis that occurs otherwise." | 7.70 | Prolonged perivascular use of verapamil or lidocaine decreases skin flap necrosis. ( Buncke, HJ; Chen, SG; Dogan, T; Komorowska-Timek, E; Lineaweaver, WC; Zhang, F, 1999) |
| "This study was designed to investigate whether two L-type calcium antagonists, verapamil and nicardipine reduce the myocardial necrosis (infarct size) following ischemia and reperfusion." | 7.70 | [Comparison of effects of verapamil and those of nicardipine on myocardial ischemia and reperfusion injury: a study in an in situ rabbit model]. ( Furuya, M; Yoshida, K, 1999) |
| ") administration of (+/-) propranolol (100-200-300 microg/animal/day, during 7 days) or (+/-) verapamil (40-80-160 microg/animal/day, during 7 days) afforded a significant protection (with the exception of the lowest dose) on the investigated parameters: arrhythmias, ischemic zone (in coronary ligated rats), lactate dehydrogenase and aspartate aminotransferase activity of the serum, focal necrosis (in isoproterenol treated rats)." | 7.70 | The influence of intracerebroventricular administration of (+/-) propranolol and (+/-) verapamil on experimental myocardial ischemia and necrosis in rats. ( Blidaru, M; Cuparencu, B; Pleşca-Manea, L, 2000) |
| "We have used the model of L-2-chloropropionic acid (L-CPA)-induced selective cerebellar granule necrosis to study excitatory amino acid-induced necrotic cell death in vivo produced by the activation of N-methyl-D-aspartate (NMDA) receptors." | 7.69 | L-2-chloropropionic acid-induced cerebellar granule cell necrosis is potentiated by L-type calcium channel antagonists. ( Gyte, A; Moores, R; Pitts, M; Smith, JC; Upton, R; Widdowson, PS; Wyatt, I, 1997) |
| "To determine whether gallopamil (D600), a methoxy derivative of verapamil, administered immediately before coronary artery reperfusion reduces the extent of myocardial hemorrhage and necrosis, the left anterior descending coronary artery was occluded for 3 h and reperfused for 3 h in anesthetized, open-chest dogs." | 7.68 | Reduction in myocardial hemorrhage and the extent of necrosis by gallopamil (D600) in dogs with coronary artery reperfusion. ( Endo, T; Hayakawa, H; Maroko, PR; Sato, N, 1991) |
| "We previously showed that combined treatment with allopurinol plus verapamil had a salutary effect on tissue necrosis during 24-h permanent coronary occlusion." | 7.67 | Influence of allopurinol plus verapamil treatment on myocardial tissue necrosis during permanent coronary occlusion in canine hearts with small infarcts. ( Denniss, AR; Kingma, JG; Yellon, DM, 1989) |
| " The effect of the sarcolemmal calcium flux inhibitor, verapamil, on myocardial necrosis was studied in dogs subjected to temporary coronary artery occlusion." | 7.65 | Effect of the calcium antagonist verapamil on necrosis following temporary coronary artery occlusion in dogs. ( Jennings, RB; Lowe, JE; Reimer, KA, 1977) |
| "Verapamil was administered at the dose of 50 mg in continuous drip." | 6.65 | [Behaviour of serum CPK curves in acute myocardial infarction treated with digitalis, verapamil and combined verapamil-digitalis (author's transl)]. ( Allegri, P; Cappelletti, F; Comacchio, G; De Lio, U; Maiolino, P; Morlino, T; Ometto, R; Vincenzi, M; Zanchetta, M, 1981) |
| "Pretreatment with verapamil reduced the size of these subendocardial infarcts from 34 +/- 8 to 8 +/- 3% of the ischemic circumflex vascular bed at risk (identified by postmortem perfusion of the previously occluded and unoccluded arteries with different dyes)." | 5.27 | Verapamil in two reperfusion models of myocardial infarction. Temporary protection of severely ischemic myocardium without limitation of ultimate infarct size. ( Jennings, RB; Reimer, KA, 1984) |
| "A 27-year-old female is admitted with an acute abdomen of 4 days after an event referred for a suicidal attempt due to an overdose of verapamil, operating surgically where there is a right transmural colon necrosis, performing a right hemicolectomy with terminal ileostomy." | 3.91 | Secondary colonic necrosis. Case report. ( Aburto-Fernández, MDC; Alvarado-González, A; Araujo-López, A; Arteaga-Villalba, LR; de Orendáin, AÁ; García-Godoy, IU; Gutiérrez-Samperio, JL; Herrera-Díaz, A; Jiménez-Ríos, CO; Lerma-Alvarado, RM; Ocio, MAR, 2019) |
| "This study was designed to investigate whether two L-type calcium antagonists, verapamil and nicardipine reduce the myocardial necrosis (infarct size) following ischemia and reperfusion." | 3.70 | [Comparison of effects of verapamil and those of nicardipine on myocardial ischemia and reperfusion injury: a study in an in situ rabbit model]. ( Furuya, M; Yoshida, K, 1999) |
| ") administration of (+/-) propranolol (100-200-300 microg/animal/day, during 7 days) or (+/-) verapamil (40-80-160 microg/animal/day, during 7 days) afforded a significant protection (with the exception of the lowest dose) on the investigated parameters: arrhythmias, ischemic zone (in coronary ligated rats), lactate dehydrogenase and aspartate aminotransferase activity of the serum, focal necrosis (in isoproterenol treated rats)." | 3.70 | The influence of intracerebroventricular administration of (+/-) propranolol and (+/-) verapamil on experimental myocardial ischemia and necrosis in rats. ( Blidaru, M; Cuparencu, B; Pleşca-Manea, L, 2000) |
| "We have used the model of L-2-chloropropionic acid (L-CPA)-induced selective cerebellar granule necrosis to study excitatory amino acid-induced necrotic cell death in vivo produced by the activation of N-methyl-D-aspartate (NMDA) receptors." | 3.69 | L-2-chloropropionic acid-induced cerebellar granule cell necrosis is potentiated by L-type calcium channel antagonists. ( Gyte, A; Moores, R; Pitts, M; Smith, JC; Upton, R; Widdowson, PS; Wyatt, I, 1997) |
| "Ca2+ accumulates in the nucleus and DNA undergoes enzymatic cleavage into internucleosome-length fragments before acetaminophen and dimethylnitrosamine produce hepatic necrosis in vivo and toxic cell death in vitro." | 3.68 | Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen. ( Corcoran, GB; Gurule, MW; Kamendulis, LM; Ray, SD; Yorkin, RD, 1993) |
| "To determine whether gallopamil (D600), a methoxy derivative of verapamil, administered immediately before coronary artery reperfusion reduces the extent of myocardial hemorrhage and necrosis, the left anterior descending coronary artery was occluded for 3 h and reperfused for 3 h in anesthetized, open-chest dogs." | 3.68 | Reduction in myocardial hemorrhage and the extent of necrosis by gallopamil (D600) in dogs with coronary artery reperfusion. ( Endo, T; Hayakawa, H; Maroko, PR; Sato, N, 1991) |
| "Cephaloridine produces proximal tubular necrosis in the rabbit kidney." | 3.68 | Effect of verapamil on cephaloridine nephrotoxicity in the rabbit. ( Browning, MC, 1990) |
| "We previously showed that combined treatment with allopurinol plus verapamil had a salutary effect on tissue necrosis during 24-h permanent coronary occlusion." | 3.67 | Influence of allopurinol plus verapamil treatment on myocardial tissue necrosis during permanent coronary occlusion in canine hearts with small infarcts. ( Denniss, AR; Kingma, JG; Yellon, DM, 1989) |
| " The present study was designed to simulate the clinical situation of reocclusion and determine whether verapamil might be effective in reducing myocardial necrosis and preserving high energy phosphates in this setting." | 3.67 | Effect of verapamil on infarct size in dogs subjected to coronary artery occlusion with transient reperfusion. ( Alker, KJ; Braunwald, E; Campbell, CA; Kloner, RA, 1986) |
| " The effect of the sarcolemmal calcium flux inhibitor, verapamil, on myocardial necrosis was studied in dogs subjected to temporary coronary artery occlusion." | 3.65 | Effect of the calcium antagonist verapamil on necrosis following temporary coronary artery occlusion in dogs. ( Jennings, RB; Lowe, JE; Reimer, KA, 1977) |
| "Verapamil was administered at the dose of 50 mg in continuous drip." | 2.65 | [Behaviour of serum CPK curves in acute myocardial infarction treated with digitalis, verapamil and combined verapamil-digitalis (author's transl)]. ( Allegri, P; Cappelletti, F; Comacchio, G; De Lio, U; Maiolino, P; Morlino, T; Ometto, R; Vincenzi, M; Zanchetta, M, 1981) |
| "Pretreatment with verapamil reduced the size of these subendocardial infarcts from 34 +/- 8 to 8 +/- 3% of the ischemic circumflex vascular bed (anatomic area at risk)." | 2.37 | Effects of calcium-channel blockers on myocardial preservation during experimental acute myocardial infarction. ( Jennings, RB; Reimer, KA, 1985) |
| " Our results show that both A beta(1-42) and A beta(25-35) are toxic to HAEC in a time- and dose-dependent manner, and that this toxicity can be partially prevented by the calcium channel blocker, verapamil, and the antioxidant, superoxide dismutase." | 1.30 | Superoxide free radical and intracellular calcium mediate A beta(1-42) induced endothelial toxicity. ( Crawford, F; Fang, C; Mullan, M; Suo, Z, 1997) |
| "Mibefradil doses were in the range of 0." | 1.30 | Cardioprotective efficacy of verapamil and mibefradil in young UM-X7.1 cardiomyopathic hamsters. ( Dumont, L; Jasmin, G; Paquette, F, 1999) |
| "Pretreatment with verapamil reduced the size of these subendocardial infarcts from 34 +/- 8 to 8 +/- 3% of the ischemic circumflex vascular bed at risk (identified by postmortem perfusion of the previously occluded and unoccluded arteries with different dyes)." | 1.27 | Verapamil in two reperfusion models of myocardial infarction. Temporary protection of severely ischemic myocardium without limitation of ultimate infarct size. ( Jennings, RB; Reimer, KA, 1984) |
| "Bepridil (10 mg/kg) was injected twice daily for 15 and 30 days." | 1.27 | Comparison of verapamil and bepridil in the therapy of familiar cardiomyopathy of the Syrian hamster. ( Hofmann, U; Kunkel, B; Mutschler, M, 1987) |
| "The effect of inhibiting isoprenaline-induced intracellular calcium accumulation on the degree of damage produced in the rat myocardium by this amine has been investigated by simultaneously dosing rats with the calcium antagonistic drug D600." | 1.26 | The effect of a calcium antagonist (D600) on isoprenaline-induced myocardial necrosis in the rat. ( Powell, T; Rowles, PM; Steen, E; Woolf, N, 1979) |
| "Fifty pregnant women admitted consecutively on account of threatened abortion or premature labour and treated with Ritodrine and Verapamil intravenously in the usual dosage were investigated with respect to creatine kinase activity and, in the event of a raised level, its isoenzyme creatine kinase--MB." | 1.26 | [Does myocardial damage arise as a result of administration of tocolytic drugs? (author's transl)]. ( Dienstl, F; Lechner, W, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (57.53) | 18.7374 |
| 1990's | 17 (23.29) | 18.2507 |
| 2000's | 9 (12.33) | 29.6817 |
| 2010's | 5 (6.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aburto-Fernández, MDC | 1 |
| Araujo-López, A | 1 |
| García-Godoy, IU | 1 |
| Alvarado-González, A | 1 |
| Gutiérrez-Samperio, JL | 1 |
| de Orendáin, AÁ | 1 |
| Ocio, MAR | 1 |
| Arteaga-Villalba, LR | 1 |
| Herrera-Díaz, A | 1 |
| Jiménez-Ríos, CO | 1 |
| Lerma-Alvarado, RM | 1 |
| Echeverri, J | 1 |
| Goldaracena, N | 1 |
| Kaths, JM | 1 |
| Linares, I | 1 |
| Roizales, R | 1 |
| Kollmann, D | 1 |
| Hamar, M | 1 |
| Urbanellis, P | 1 |
| Ganesh, S | 1 |
| Adeyi, OA | 1 |
| Tazari, M | 1 |
| Selzner, M | 1 |
| Selzner, N | 1 |
| Russell, NJ | 1 |
| Irwin, PJ | 1 |
| Hopper, BJ | 1 |
| Olivry, T | 1 |
| Nicholls, PK | 1 |
| Rinker, B | 1 |
| Fink, BF | 1 |
| Barry, NG | 1 |
| Fife, JA | 1 |
| Milan, ME | 1 |
| Yang, YT | 1 |
| Whiteman, M | 1 |
| Gieseg, SP | 1 |
| Chen, Q | 1 |
| Guo, F | 1 |
| Liu, S | 1 |
| Xiao, J | 1 |
| Wang, C | 1 |
| Snowise, S | 1 |
| Stone, PR | 1 |
| Chamley, LW | 1 |
| Sparrow, RL | 1 |
| Tippett, E | 1 |
| Xu, D | 1 |
| Wu, Y | 1 |
| Liao, ZX | 1 |
| Wang, H | 1 |
| Shan, D | 1 |
| Marchase, RB | 1 |
| Chatham, JC | 1 |
| Stojiljković, N | 1 |
| Veljković, S | 1 |
| Mihailović, D | 1 |
| Stoiljković, M | 1 |
| Radovanović, D | 1 |
| Randelović, P | 1 |
| Kolts, BE | 1 |
| Langfitt, M | 1 |
| Ostádal, B | 1 |
| Widimský, J | 1 |
| Urbanová, D | 1 |
| Procházka, J | 1 |
| Pelouch, V | 1 |
| Reimer, KA | 3 |
| Jennings, RB | 3 |
| Yellon, DM | 3 |
| Hearse, DJ | 1 |
| Maxwell, MP | 1 |
| Chambers, DE | 1 |
| Downey, JM | 1 |
| Tereshchenko, VP | 1 |
| Nizhenkovskaia, IV | 1 |
| Vincenzi, M | 1 |
| Allegri, P | 1 |
| Cappelletti, F | 1 |
| Comacchio, G | 1 |
| De Lio, U | 1 |
| Morlino, T | 1 |
| Ometto, R | 1 |
| Zanchetta, M | 1 |
| Maiolino, P | 1 |
| Braunwald, E | 3 |
| DeBoer, LW | 1 |
| Glogar, DH | 1 |
| Darsee, JR | 1 |
| Ertl, G | 1 |
| Ingwall, JS | 1 |
| Kloner, RA | 3 |
| Factor, SM | 1 |
| Minase, T | 1 |
| Cho, S | 1 |
| Dominitz, R | 1 |
| Sonnenblick, EH | 1 |
| Aquaro, G | 1 |
| Ravera, A | 1 |
| Belli, R | 1 |
| Rey, L | 1 |
| Possavino, G | 1 |
| Pavia, M | 1 |
| Idone, P | 1 |
| Cantelli, I | 1 |
| Bracchetti, D | 1 |
| Rosenberg, GA | 1 |
| Navratil, MJ | 1 |
| Ray, SD | 1 |
| Kamendulis, LM | 1 |
| Gurule, MW | 1 |
| Yorkin, RD | 1 |
| Corcoran, GB | 1 |
| Suo, Z | 1 |
| Fang, C | 1 |
| Crawford, F | 1 |
| Mullan, M | 1 |
| Galenko-Iaroshevskiĭ, PA | 1 |
| Melkumova, ER | 1 |
| Bartashevich, VV | 1 |
| Uvarov, AV | 1 |
| Turovaia, AIu | 1 |
| Khankoeva, AI | 1 |
| Galygo, DS | 1 |
| Widdowson, PS | 1 |
| Gyte, A | 1 |
| Upton, R | 1 |
| Smith, JC | 1 |
| Pitts, M | 1 |
| Moores, R | 1 |
| Wyatt, I | 1 |
| Komorowska-Timek, E | 1 |
| Chen, SG | 1 |
| Zhang, F | 1 |
| Dogan, T | 1 |
| Lineaweaver, WC | 1 |
| Buncke, HJ | 1 |
| Furuya, M | 1 |
| Yoshida, K | 1 |
| Thévenod, F | 1 |
| Friedmann, JM | 1 |
| Katsen, AD | 1 |
| Hauser, IA | 1 |
| Paquette, F | 1 |
| Jasmin, G | 2 |
| Dumont, L | 1 |
| Blidaru, M | 1 |
| Cuparencu, B | 1 |
| Pleşca-Manea, L | 1 |
| Lazareth, I | 1 |
| Pereira, LM | 1 |
| Mandarim-de-Lacerda, CA | 1 |
| Strubelt, O | 2 |
| Siegers, CP | 2 |
| Lossnitzer, K | 1 |
| Konrad, A | 1 |
| Heine, HW | 1 |
| Ziegler, E | 1 |
| Stauch, M | 1 |
| Hofmann, W | 1 |
| Schleich, A | 1 |
| Schroeter, D | 1 |
| Weidinger, H | 1 |
| Wiest, W | 1 |
| Ferrari, R | 1 |
| Visioli, O | 1 |
| Nayler, WG | 1 |
| Steen, E | 1 |
| Woolf, N | 1 |
| Powell, T | 1 |
| Rowles, PM | 1 |
| Lechner, W | 1 |
| Dienstl, F | 1 |
| Polverino, W | 1 |
| Genovese, A | 1 |
| Cacciapuoti, AA | 1 |
| Latte, S | 1 |
| Petillo, F | 1 |
| Basso, A | 1 |
| Condorelli, M | 1 |
| Willstein, A | 1 |
| Breinl, H | 1 |
| Meinen, K | 1 |
| Schmidt, EW | 1 |
| Leder, O | 6 |
| Lowe, JE | 1 |
| Hoffmann, A | 1 |
| Sierra-Callejas, JL | 1 |
| Janke, J | 3 |
| Fleckenstein, A | 6 |
| Döring, HJ | 4 |
| Sigel, H | 1 |
| Bajusz, E | 1 |
| Kanke, J | 1 |
| Aliev, MA | 2 |
| Lemeshenko, VA | 1 |
| Bekbolotova, AK | 1 |
| Kostiuchenko, LS | 1 |
| Endo, T | 1 |
| Sato, N | 1 |
| Hayakawa, H | 1 |
| Maroko, PR | 1 |
| Gossner, L | 1 |
| Wittke, H | 1 |
| Warzecha, A | 1 |
| Sroka, R | 1 |
| Ernst, H | 1 |
| Meier, M | 1 |
| Ell, C | 1 |
| Kawabata, H | 1 |
| Knight, KR | 1 |
| Coe, SA | 1 |
| Angus, JA | 1 |
| O'Brien, BM | 1 |
| Shvilkin, AV | 1 |
| Afonskaia, NI | 1 |
| Sadretdinov, SM | 1 |
| Cherpachenko, NM | 1 |
| Levitskiĭ, DO | 1 |
| Ruda, MIa | 1 |
| Block, F | 1 |
| Jaspers, RM | 1 |
| Heim, C | 1 |
| Sontag, KH | 1 |
| Browning, MC | 1 |
| Hornsey, S | 1 |
| Myers, R | 1 |
| Jenkinson, T | 1 |
| Kingma, JG | 2 |
| Denniss, AR | 1 |
| Hsueh, W | 1 |
| Gonzalez-Crussi, F | 1 |
| Arroyave, JL | 1 |
| Vassanelli, C | 1 |
| Menegatti, G | 1 |
| Nidasio, GP | 1 |
| Franceschini, L | 1 |
| Cocco, C | 1 |
| Rizzotti, P | 1 |
| Kunkel, B | 1 |
| Hofmann, U | 1 |
| Mutschler, M | 1 |
| Sobh, MA | 1 |
| el-Sharabasy, MM | 1 |
| Campbell, CA | 1 |
| Alker, KJ | 1 |
| Yamashita, T | 1 |
| Kobayashi, A | 1 |
| Yamazaki, N | 1 |
| Miura, K | 1 |
| Shirasawa, H | 1 |
| Todd, GL | 1 |
| Sterns, DA | 1 |
| Plambeck, RD | 1 |
| Joekel, CS | 1 |
| Eliot, RS | 1 |
| Novitzky, D | 1 |
| Cooper, DK | 1 |
| Rose, AG | 1 |
| Reichart, B | 1 |
| Gaba, DM | 1 |
| Metz, S | 1 |
| Maze, M | 1 |
| Lo, HM | 1 |
| Reindell, A | 1 |
2 reviews available for verapamil and Necrosis
| Article | Year |
|---|---|
[Management of Raynaud's phenomenon].
Topics: Adult; Age Distribution; Calcium Channel Blockers; Female; Humans; Iloprost; Losartan; Male; Middle | 2001 |
Effects of calcium-channel blockers on myocardial preservation during experimental acute myocardial infarction.
Topics: Animals; Calcium Channel Blockers; Collateral Circulation; Coronary Circulation; Coronary Disease; D | 1985 |
1 trial available for verapamil and Necrosis
| Article | Year |
|---|---|
[Behaviour of serum CPK curves in acute myocardial infarction treated with digitalis, verapamil and combined verapamil-digitalis (author's transl)].
Topics: Adult; Aged; Clinical Enzyme Tests; Creatine Kinase; Digoxin; Female; Glucose; Humans; Insulin; Male | 1981 |
70 other studies available for verapamil and Necrosis
| Article | Year |
|---|---|
Secondary colonic necrosis. Case report.
Topics: Abdomen, Acute; Abdominal Abscess; Adult; Colectomy; Colon; Drainage; Female; Humans; Hypotension; I | 2019 |
Comparison of BQ123, Epoprostenol, and Verapamil as Vasodilators During Normothermic Ex Vivo Liver Machine Perfusion.
Topics: Animals; Apoptosis; Calcium Channel Blockers; Endothelin Receptor Antagonists; Epoprostenol; Hepatic | 2018 |
Acute necrotising pulmonary vasculitis and pulmonary hypertension in a juvenile dog.
Topics: Acute Disease; Animals; Anti-Anxiety Agents; Dog Diseases; Dogs; Fatal Outcome; Female; Furosemide; | 2008 |
The effect of calcium channel blockers on smoking-induced skin flap necrosis.
Topics: Animals; Calcium Channel Blockers; Cotinine; Graft Survival; Male; Necrosis; Nicotine; Nifedipine; R | 2010 |
HOCl causes necrotic cell death in human monocyte derived macrophages through calcium dependent calpain activation.
Topics: Calcimycin; Calcium; Calcium Channel Blockers; Calcium Ionophores; Calpain; Caspase 3; Cyclosporine; | 2012 |
Calcium channel blockers prevent endothelial cell activation in response to necrotic trophoblast debris: possible relevance to pre-eclampsia.
Topics: Adolescent; Adult; Calcium Channel Blockers; Case-Control Studies; Cell Adhesion; Cell Proliferation | 2012 |
Discrimination of live and early apoptotic mononuclear cells by the fluorescent SYTO 16 vital dye.
Topics: Apoptosis; Cell Survival; Fetal Blood; Flow Cytometry; Fluorescent Dyes; Humans; Infant, Newborn; Ju | 2005 |
Protective effect of verapamil on multiple hepatotoxic factors-induced liver fibrosis in rats.
Topics: Actins; Alanine Transaminase; Animals; Carbon Tetrachloride; Collagen; Dietary Fats; Disease Models, | 2007 |
Overexpression of TRPC3 increases apoptosis but not necrosis in response to ischemia-reperfusion in adult mouse cardiomyocytes.
Topics: Acrylates; Animals; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium | 2008 |
The effect of calcium channel blocker verapamil on gentamicin nephrotoxicity in rats.
Topics: Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Calcium Channel Blockers; Gentamicins; Kidney; | 2008 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
[Verapamil in rats exposed to intermittent altitude hypoxia. Its effect on pulmonary hypertension, right ventricular hypertrophy and myocardial necroses (author's transl)].
Topics: Animals; Cardiomegaly; Hypertension, Pulmonary; Hypoxia; Male; Myocardium; Necrosis; Rats; Rats, Inb | 1981 |
Verapamil in two reperfusion models of myocardial infarction. Temporary protection of severely ischemic myocardium without limitation of ultimate infarct size.
Topics: Animals; Collateral Circulation; Coronary Circulation; Coronary Disease; Disease Models, Animal; Dog | 1984 |
Sustained limitation of myocardial necrosis 24 hours after coronary artery occlusion: verapamil infusion in dogs with small myocardial infarcts.
Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Female; Hemodynamics; Male; Myocardial Infarc | 1983 |
[Morphological bases of the effect of verapamil on the heart in experimental acute coronary failure].
Topics: Acute Disease; Animals; Coronary Disease; Drug Evaluation, Preclinical; Heart; Myocardial Infarction | 1983 |
Observations on the experimental reduction of infarct size and on the delayed consequences of transient myocardial ischemia.
Topics: Animals; Captopril; Dogs; Fluorocarbons; Flurbiprofen; Myocardial Infarction; Myocardium; Necrosis; | 1981 |
Microvascular spasm in the cardiomyopathic Syrian hamster: a preventable cause of focal myocardial necrosis.
Topics: Animals; Cardiomyopathies; Coronary Circulation; Cricetinae; Mesocricetus; Microcirculation; Muscle, | 1982 |
[Verapamil in the acute phase of myocardial infarct].
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardium; Necrosis; Nitropr | 1981 |
[The X, Y and Z orthogonal leads of the Frank vectorial system. An alternative to the precordial mapping of the ST segment in evaluation of ischemic damage in acute myocardial infarct].
Topics: Acute Disease; Adult; Aged; Electrocardiography; Female; Humans; Isosorbide Dinitrate; Male; Middle | 1980 |
(S)-emopamil reduces brain edema from collagenase-induced hemorrhage in rats.
Topics: Animals; Body Water; Brain Chemistry; Brain Edema; Calcium Channel Blockers; Cerebral Hemorrhage; Co | 1994 |
Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen.
Topics: Acetaminophen; Animals; Biotransformation; Calcium; Calcium Channel Blockers; Cell Death; Chlorproma | 1993 |
Superoxide free radical and intracellular calcium mediate A beta(1-42) induced endothelial toxicity.
Topics: Amyloid beta-Peptides; Antipsychotic Agents; Aorta; Apoptosis; Calcium; Calcium Channel Blockers; Ce | 1997 |
[Comparative evaluation of the effect of dimebon, obzidan, finoptin, and cordarone on the functional state of the ischemic focus and the size of necrosis zone during experimental myocardial infarction].
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cats; Histamine H1 Antagonists; Indoles; Myocardial Inf | 1996 |
L-2-chloropropionic acid-induced cerebellar granule cell necrosis is potentiated by L-type calcium channel antagonists.
Topics: Animals; Aspartic Acid; Body Weight; Calcium Channel Blockers; Cerebellar Diseases; Cerebellum; Drug | 1997 |
Prolonged perivascular use of verapamil or lidocaine decreases skin flap necrosis.
Topics: Administration, Topical; Animals; Lidocaine; Necrosis; Postoperative Period; Rats; Rats, Sprague-Daw | 1999 |
[Comparison of effects of verapamil and those of nicardipine on myocardial ischemia and reperfusion injury: a study in an in situ rabbit model].
Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Disease Models, Animal; Myocardial Ischem | 1999 |
Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis.
Topics: Animals; Annexin A5; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cadmium; Ca | 2000 |
Cardioprotective efficacy of verapamil and mibefradil in young UM-X7.1 cardiomyopathic hamsters.
Topics: Animals; Biomarkers; Calcinosis; Calcium Channel Blockers; Cardiomyopathies; Cardiovascular Agents; | 1999 |
The influence of intracerebroventricular administration of (+/-) propranolol and (+/-) verapamil on experimental myocardial ischemia and necrosis in rats.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Female; Injections, Intr | 2000 |
Stereology of cardiac hypertrophy induced by NO blockade in rats treated with enalapril and verapamil.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Apoptosis; Blood Pressur | 2001 |
Role of cardiovascular and ionic changes in pathogenesis and prevention of isoprenaline-induced cardiac necrosis.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cardiomyopathies; Heart Rate; Hydrogen-Ion Concentration; I | 1975 |
[Proceedings: Prevention of myocardial degeneration in a disease model of hereditary cardiomyopathy].
Topics: Animals; Calcium; Cardiomegaly; Cardiomyopathies; Cricetinae; Disease Models, Animal; Heart; Myocard | 1975 |
[The influence of beta-sympathomimetics and so-called Ca++-antagonistic inhibitors on human heart muscle in vitro (author's transl)].
Topics: Calcium; Ethanolamines; Female; Fenoterol; Fetal Diseases; Fetal Heart; Humans; Labor, Induced; Micr | 1977 |
[Protective effect of verapamil on the damage caused by coronary insufficiency. Experimental research].
Topics: Animals; Calcium; Coronary Circulation; Mitochondria, Heart; Myocardial Infarction; Myocardium; Necr | 1978 |
The effect of a calcium antagonist (D600) on isoprenaline-induced myocardial necrosis in the rat.
Topics: Animals; Calcium; Cardiomyopathies; Gallopamil; Isoproterenol; Male; Myocardium; Necrosis; Rats; Ver | 1979 |
[Does myocardial damage arise as a result of administration of tocolytic drugs? (author's transl)].
Topics: Abortion, Threatened; Adolescent; Adult; Cardiomyopathies; Creatine Kinase; Female; Humans; Isoenzym | 1979 |
[Pharmacological protection of the cardiac mucle in experimental infarct. II. Effects of verapamil].
Topics: Animals; Calcium; Male; Myocardial Infarction; Myocardium; Necrosis; Rats; Verapamil | 1979 |
[The possibility of heart-muscle damage through fenoterol (elektrocardiographic and blood-chemistry studies with particular reference to the heart-muscle-specific isoenzym creatinkinase MB.) (author's transl)].
Topics: Adult; Creatine Kinase; Drug Synergism; Electrocardiography; Ethanolamines; Female; Fenoterol; Heart | 1977 |
[Microscopic quantification of myocardial necroses in experimental cardiology].
Topics: Animals; Calcitonin; Dose-Response Relationship, Drug; Gallopamil; Histological Techniques; Isoprote | 1976 |
Effect of the calcium antagonist verapamil on necrosis following temporary coronary artery occlusion in dogs.
Topics: Animals; Calcium; Coronary Disease; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclin | 1977 |
On the pathogenesis of cardiac necroses induced by theophylline and caffeine.
Topics: Animals; Blood Pressure; Caffeine; Calcium; Gallopamil; Heart; Heart Rate; Isoproterenol; Male; Myoc | 1976 |
[Key-role of intracellular calcium overload in acute necrosis of the myocardium. Cardioprotection with verapamil].
Topics: Adenosine Triphosphate; Animals; Calcium; Catecholamines; Dihydrotachysterol; Fludrocortisone; Heart | 1975 |
Restriction of isoproterenol-induced myocardial Ca uptake and necrotization in rats by a new Ca-antagonistic compound (ethyl-4-(3,4,5-trimethoxycinnamoyl) piperazinyl acetate (Vascordil)).
Topics: Animals; Biological Transport; Calcium; Cardiomyopathies; Cinnamates; Dose-Response Relationship, Dr | 1975 |
Prevention of myocardial generation in hamsters with hereditary cardiomyopathy.
Topics: Alkaline Phosphatase; Animals; Cardiomyopathies; Cricetinae; Dibenzylchlorethamine; Female; Male; Mu | 1975 |
Key role of Ca in the production of noncoronarogenic myocardial necroses.
Topics: Adenosine Triphosphate; Animals; Calcium; Cardiomyopathies; Heart; Humans; Isoproterenol; Muscles; N | 1975 |
[Prostacyclin-thromboxane imbalance after adrenergic damage of the heart and aorta and its correction with calcium antagonist finoptin and the adaptation to high-altitude climate].
Topics: Adaptation, Physiological; Altitude; Animals; Aorta, Abdominal; Disease Models, Animal; Epinephrine; | 1992 |
[Effects of calcium antagonist finoptin on superoxide dismutase activity and conditioned reflex memory in adrenergic cardiac necroso-genic stress in rats].
Topics: Animals; Avoidance Learning; Brain; Conditioning, Classical; Epinephrine; Female; Male; Myocardium; | 1992 |
Reduction in myocardial hemorrhage and the extent of necrosis by gallopamil (D600) in dogs with coronary artery reperfusion.
Topics: Animals; Autoradiography; Blood Pressure; Coronary Vessels; Dogs; Female; Gallopamil; Heart Diseases | 1991 |
Verapamil and hematoporphyrin derivative for tumour destruction by photodynamic therapy.
Topics: Animals; Antineoplastic Agents; Cell Line; Female; Fibrosarcoma; Hematoporphyrin Derivative; Hematop | 1991 |
Experience with calcium antagonists nitrendipine, diltiazem, and verapamil and beta 2-agonist salbutamol in salvaging ischemic skin flaps in rabbits.
Topics: Albuterol; Animals; Calcium Channel Blockers; Diltiazem; Injections, Intravenous; Ischemia; Necrosis | 1991 |
[Effects of verapamil and nitroglycerin on experimental occlusion- reperfusion-induced myocardial infarction in rabbits].
Topics: Animals; Coronary Vessels; Disease Models, Animal; Drug Evaluation, Preclinical; Ligation; Male; Myo | 1991 |
S-emopamil ameliorates ischemic brain damage in rats: histological and behavioural approaches.
Topics: Animals; Behavior, Animal; Brain; Cerebral Cortex; Hippocampus; Ischemic Attack, Transient; Learning | 1990 |
Effect of verapamil on cephaloridine nephrotoxicity in the rabbit.
Topics: Animals; Calcium; Cephaloridine; Female; Kidney Cortex; Kidney Diseases; Kidney Tubular Necrosis, Ac | 1990 |
The reduction of radiation damage to the spinal cord by post-irradiation administration of vasoactive drugs.
Topics: Animals; Deferoxamine; Dipyridamole; Male; Necrosis; Radiation Injuries, Experimental; Rats; Reperfu | 1990 |
Influence of allopurinol plus verapamil treatment on myocardial tissue necrosis during permanent coronary occlusion in canine hearts with small infarcts.
Topics: Allopurinol; Animals; Calcium; Coronary Circulation; Dogs; Free Radicals; Hemodynamics; Male; Myocar | 1989 |
Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis.
Topics: Alprostadil; Animals; Blood Pressure; Catechols; Chromones; Diethylcarbamazine; Disease Models, Anim | 1986 |
Comparison of different pharmacological interventions on enzymatic parameters during acute myocardial infarction.
Topics: Adult; Aged; Clinical Enzyme Tests; Creatine Kinase; Dipyridamole; Female; Heart; Heparin; Humans; I | 1987 |
Limitation of myocardial necrosis with verapamil during sustained coronary occlusion in the closed-chest dog.
Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Heart Diseases; Male; Necrosis; Verapamil | 1988 |
Comparison of verapamil and bepridil in the therapy of familiar cardiomyopathy of the Syrian hamster.
Topics: Animals; Bepridil; Calcium; Cardiomyopathies; Cricetinae; Muscles; Necrosis; Osmolar Concentration; | 1987 |
Protective effect of verapamil on ischaemic renal injury in dogs.
Topics: Alkaline Phosphatase; Animals; Dogs; Female; Glomerular Filtration Rate; Ischemia; Kidney; Kidney Tu | 1987 |
Effect of verapamil on infarct size in dogs subjected to coronary artery occlusion with transient reperfusion.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Dogs; Femal | 1986 |
Effects of L-carnitine and verapamil on myocardial carnitine concentration and histopathology of Syrian hamster BIO 14.6.
Topics: Animals; Calcinosis; Cardiomyopathies; Carnitine; Cricetinae; Fibrosis; Mesocricetus; Myocardium; Ne | 1986 |
Protective effects of slow channel calcium antagonists on noradrenaline induced myocardial necrosis.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dogs; Electrocardiography; Female; Heart; Hemodynamics | 1986 |
Prevention of myocardial injury by pretreatment with verapamil hydrochloride prior to experimental brain death: efficacy in a baboon model.
Topics: Animals; Brain Death; Heart; Hemodynamics; Myocardium; Necrosis; Papio; Pulmonary Circulation; Tissu | 1987 |
Postcountershock myocardial damage after pretreatment with adrenergic and calcium channel antagonists in halothane-anesthetized dogs.
Topics: Anesthesia, Inhalation; Animals; Calcium Channel Blockers; Dogs; Electric Countershock; Female; Halo | 1985 |
Effect of intracoronary verapamil on infarct size in the ischemic, reperfused canine heart: critical importance of the timing of treatment.
Topics: Animals; Blood Pressure; Coronary Circulation; Dogs; Female; Heart; Heart Rate; Male; Myocardial Inf | 1985 |
Proceedings: Changes in myocardial ultrastructure and autoradiographic 45Ca distribution during isoproterenol-induced cardiac necrotization--prevention by Ca-antagonistic compounds.
Topics: Adrenal Cortex Hormones; Animals; Autoradiography; Calcium; Calcium Radioisotopes; Dihydrotachystero | 1974 |
Myocardial fiber necrosis due to intracellular Ca overload-a new principle in cardiac pathophysiology.
Topics: Ammonium Chloride; Animals; Biological Transport; Calcitonin; Calcium; Cardiomyopathies; Dihydrotach | 1974 |
[Protective effect of organic Ca antagonists (iproveratril, D 600, prenylamine) against isoproterenol-induced myocardial necrosis].
Topics: Animals; Anti-Arrhythmia Agents; Calcium; Heart; Heart Diseases; Isoproterenol; Necrosis; Nitriles; | 1969 |
[Control of myocardial metabolism by verapamil. Sites of action and therapeutic effects].
Topics: Animals; Anti-Arrhythmia Agents; Calcium; Cell Membrane Permeability; Guinea Pigs; Heart; Heart Cond | 1970 |