Histone-lysine N-methyltransferase 2A

A histone-lysine N-methyltransferase 2A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q03164]

Synonyms

Lysine N-methyltransferase 2A;
EC 2.1.1.354;
ALL-1;
CXXC-type zinc finger protein 7;
Myeloid/lymphoid or mixed-lineage leukemia;
Myeloid/lymphoid or mixed-lineage leukemia protein 1;
Trithorax-like protein;
Zinc finger protein

Research

Bioassay Publications (9)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (55.56)	24.3611
2020's	4 (44.44)	2.80

Compounds (9)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
lansoprazole	Homo sapiens (human)	IC50	5.9000	1	1
omeprazole	Homo sapiens (human)	IC50	1.7000	1	1
rabeprazole	Homo sapiens (human)	IC50	0.4900	1	1
s-adenosylhomocysteine	Homo sapiens (human)	IC50	1.5120	2	2
scutellarein	Homo sapiens (human)	IC50	2.9200	1	1
dexlansoprazole	Homo sapiens (human)	IC50	5.7000	1	1
4-[4-(5,5-dimethyl-4H-thiazol-2-yl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine	Homo sapiens (human)	IC50	0.5250	2	2
gsk343	Homo sapiens (human)	IC50	100.0000	1	1
6,7-dimethoxy-2-(pyrrolidin-1-yl)-n-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	Homo sapiens (human)	IC50	100.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
4-[4-(5,5-dimethyl-4H-thiazol-2-yl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine	Homo sapiens (human)	Kd	0.1580	1	1

Enables

This protein enables 12 target(s):

Target	Category	Definition
minor groove of adenine-thymine-rich DNA binding	molecular function	Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins. [GOC:jl, PMID:10545119, PMID:15802641, PMID:26223912, PMID:2670564]
chromatin binding	molecular function	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
histone H3K4 methyltransferase activity	molecular function	Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein. [PMID:12086618]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
unmethylated CpG binding	molecular function	Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters. [GOC:ai, PMID:10688657]
lysine-acetylated histone binding	molecular function	Binding to a histone in which a lysine residue has been modified by acetylation. [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]
protein-cysteine methyltransferase activity	molecular function	Catalysis of the reaction: L-cysteinyl-[protein] + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]. [GOC:sp, PMID:21481189, PMID:22158122, PMID:24235145, PMID:25412445, RHEA:66544]
histone H3K4 monomethyltransferase activity	molecular function	Catalysis of the reaction: L-lysyl4-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me. [RHEA:60264]
histone H3K4 trimethyltransferase activity	molecular function	Catalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3. [PMID:18375658, RHEA:60260]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
MLL1 complex	cellular component	A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5. [GOC:sp, PMID:15960975]
histone methyltransferase complex	cellular component	A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. [GOC:bf]

Involved In

This protein is involved in 24 target(s):

Target	Category	Definition
apoptotic process	biological process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
visual learning	biological process	Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue. [GOC:jid, ISBN:0582227089]
post-embryonic development	biological process	The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. [GOC:go_curators]
anterior/posterior pattern specification	biological process	The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
methylation	biological process	The process in which a methyl group is covalently attached to a molecule. [GOC:mah]
circadian regulation of gene expression	biological process	Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. [GOC:mah]
embryonic hemopoiesis	biological process	The stages of blood cell formation that take place within the embryo. [GOC:bf]
exploration behavior	biological process	The specific behavior of an organism in response to a novel environment or stimulus. [GOC:BHF, GOC:pr, PMID:11682103, PMID:9767169]
response to potassium ion	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. [GOC:yaf]
protein modification process	biological process	The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). [GOC:bf, GOC:jl]
T-helper 2 cell differentiation	biological process	The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4. [CL:0000546, GOC:ebc]
transcription initiation-coupled chromatin remodeling	biological process	An epigenetic mechanism of regulation of gene expression that involves chromatin remodeling to capacitate gene expression by either modifying the chromatin fiber, the nucleosomal histones, or the DNA. [PMID:34414474]
positive regulation of DNA-templated transcription	biological process	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
fibroblast proliferation	biological process	The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. [GOC:jid]
negative regulation of fibroblast proliferation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. [GOC:jid]
regulation of short-term neuronal synaptic plasticity	biological process	A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. [GOC:jid, PMID:11891290]
spleen development	biological process	The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. [GOC:add, ISBN:0781735149]
homeostasis of number of cells within a tissue	biological process	Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. [GOC:isa_complete]
membrane depolarization	biological process	The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:dh, Wikipedia:Depolarization]
definitive hemopoiesis	biological process	A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood. [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691]
protein-containing complex assembly	biological process	The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. [GOC:jl]
cellular response to transforming growth factor beta stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. [GOC:ecd, PMID:15451575]
negative regulation of DNA methylation-dependent heterochromatin formation	biological process	Any process that decreases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation. [GOC:BHF]