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Carbonic anhydrase
[no definition available]
Synonyms
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (45)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| hydrobromic acid | Methanothermobacter thermautotrophicus str. Delta H | Ki | 42,100.0000 | 1 | 1 |
| hydrochloric acid | Methanothermobacter thermautotrophicus str. Delta H | Ki | 152,000.0000 | 1 | 1 |
| hydrogen sulfide | Methanothermobacter thermautotrophicus str. Delta H | Ki | 700.0000 | 1 | 1 |
| carbonic acid | Methanothermobacter thermautotrophicus str. Delta H | Ki | 27,250.0000 | 1 | 2 |
| hydrogen cyanide | Methanothermobacter thermautotrophicus str. Delta H | Ki | 27,800.0000 | 1 | 1 |
| thiocyanic acid | Methanothermobacter thermautotrophicus str. Delta H | Ki | 520.0000 | 1 | 1 |
| nitric acid | Methanothermobacter thermautotrophicus str. Delta H | Ki | 7,800.0000 | 1 | 1 |
| sulfuric acid | Methanothermobacter thermautotrophicus str. Delta H | Ki | 497,550.0000 | 1 | 2 |
| acetazolamide | Methanothermobacter thermautotrophicus str. Delta H | Ki | 12.1000 | 4 | 4 |
| celecoxib | Methanothermobacter thermautotrophicus str. Delta H | Ki | 38.5000 | 1 | 1 |
| dichlorphenamide | Methanothermobacter thermautotrophicus str. Delta H | Ki | 105.0000 | 1 | 1 |
| ethoxzolamide | Methanothermobacter thermautotrophicus str. Delta H | Ki | 5.3500 | 1 | 1 |
| mafenide | Methanothermobacter thermautotrophicus str. Delta H | Ki | 28.5000 | 1 | 1 |
| methazolamide | Methanothermobacter thermautotrophicus str. Delta H | Ki | 32.1000 | 1 | 1 |
| sulfanilamide | Methanothermobacter thermautotrophicus str. Delta H | Ki | 57.8000 | 1 | 1 |
| sulfamic acid | Methanothermobacter thermautotrophicus str. Delta H | Ki | 73,500.0000 | 2 | 2 |
| hydrofluoric acid | Methanothermobacter thermautotrophicus str. Delta H | Ki | 1,000,000.0000 | 1 | 1 |
| nitrous acid | Methanothermobacter thermautotrophicus str. Delta H | Ki | 44,800.0000 | 1 | 1 |
| hydrazoic acid | Methanothermobacter thermautotrophicus str. Delta H | Ki | 55,700.0000 | 1 | 1 |
| hydroiodic acid | Methanothermobacter thermautotrophicus str. Delta H | Ki | 13,200.0000 | 1 | 1 |
| benzeneboronic acid | Methanothermobacter thermautotrophicus str. Delta H | Ki | 200.0000 | 1 | 1 |
| 4-amino-6-chloro-1,3-benzenedisulfonamide | Methanothermobacter thermautotrophicus str. Delta H | Ki | 62.1000 | 1 | 1 |
| 2,4-disulfamyl-5-trifluoromethylaniline | Methanothermobacter thermautotrophicus str. Delta H | Ki | 50.0000 | 1 | 1 |
| sulfamide | Methanothermobacter thermautotrophicus str. Delta H | Ki | 271,500.0000 | 2 | 2 |
| valdecoxib | Methanothermobacter thermautotrophicus str. Delta H | Ki | 61.0000 | 1 | 1 |
| 4-(2-aminoethyl)benzenesulfonamide | Methanothermobacter thermautotrophicus str. Delta H | Ki | 25.7000 | 1 | 1 |
| dorzolamide | Methanothermobacter thermautotrophicus str. Delta H | Ki | 30.7000 | 1 | 1 |
| topiramate | Methanothermobacter thermautotrophicus str. Delta H | Ki | 23.5000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| histamine | Methanothermobacter thermautotrophicus str. Delta H | Ka | 76.0000 | 1 | 1 |
| histamine | Methanothermobacter thermautotrophicus str. Delta H | Km | 1,700.0000 | 1 | 1 |
| acetazolamide | Methanothermobacter thermautotrophicus str. Delta H | Kinact | 12.1000 | 1 | 1 |
| levodopa | Methanothermobacter thermautotrophicus str. Delta H | Ka | 11.4000 | 1 | 1 |
| tyrosine | Methanothermobacter thermautotrophicus str. Delta H | Ka | 10.5000 | 1 | 1 |
| phenylalanine | Methanothermobacter thermautotrophicus str. Delta H | Ka | 70.0000 | 1 | 1 |
| histidine | Methanothermobacter thermautotrophicus str. Delta H | Ka | 69.0000 | 1 | 1 |
| tryptophan | Methanothermobacter thermautotrophicus str. Delta H | Ka | 16.9000 | 1 | 1 |
| aminoethylpiperazine | Methanothermobacter thermautotrophicus str. Delta H | Ka | 13.8000 | 1 | 1 |
| D-tryptophan | Methanothermobacter thermautotrophicus str. Delta H | Ka | 41.0000 | 1 | 1 |
| 2-(aminomethyl)pyridine | Methanothermobacter thermautotrophicus str. Delta H | Ka | 18.7000 | 1 | 1 |
| benzeneboronic acid | Methanothermobacter thermautotrophicus str. Delta H | Kinact | 200.0000 | 1 | 1 |
| copper histidine | Methanothermobacter thermautotrophicus str. Delta H | Ka | 57.0000 | 1 | 1 |
| D-tyrosine | Methanothermobacter thermautotrophicus str. Delta H | Ka | 19.2000 | 1 | 1 |
| phenylalanine | Methanothermobacter thermautotrophicus str. Delta H | Ka | 10.3000 | 1 | 1 |
| 2-(2-aminoethyl)pyridine | Methanothermobacter thermautotrophicus str. Delta H | Ka | 40.0000 | 1 | 1 |
| sulfamide | Methanothermobacter thermautotrophicus str. Delta H | Kinact | 103,000.0000 | 1 | 1 |
| D-dopa | Methanothermobacter thermautotrophicus str. Delta H | Ka | 15.6000 | 1 | 1 |
| 4-aminophenylalanine | Methanothermobacter thermautotrophicus str. Delta H | Ka | 89.0000 | 1 | 1 |
| epitrate | Methanothermobacter thermautotrophicus str. Delta H | Ka | 11.5000 | 1 | 1 |
| 4-2-Aminoethyl-morpholine | Methanothermobacter thermautotrophicus str. Delta H | Ka | 18.5000 | 1 | 1 |
Anion inhibition studies of a β-carbonic anhydrase from Clostridium perfringens.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 18, Issue:18, 2008
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 18, Issue:18, 2008
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 18, Issue:18, 2008
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004