A CDK-activating kinase assembly factor MAT1 that is encoded in the genome of human. [PRO:DNx]
CDK7/cyclin-H assembly factor;
Cyclin-G1-interacting protein;
Menage a trois;
RING finger protein 66;
RING finger protein MAT1;
p35;
p36
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (61.11) | 24.3611 |
| 2020's | 7 (38.89) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| gw8510 | Homo sapiens (human) | IC50 | 0.3170 | 1 | 1 |
| nu6102 | Homo sapiens (human) | IC50 | 2.5000 | 1 | 1 |
| staurosporine | Homo sapiens (human) | IC50 | 0.1216 | 4 | 4 |
| cyc 202 | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| 2H-pyrazolo[4,3-b]quinoxalin-3-amine | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| 6-bromoindirubin-3'-oxime | Homo sapiens (human) | IC50 | 3.5000 | 1 | 1 |
| 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| cgp 60474 | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| cgp 74514a | Homo sapiens (human) | IC50 | 0.2790 | 1 | 1 |
| 1,4-dimethoxy-10H-acridine-9-thione | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| bms 387032 | Homo sapiens (human) | IC50 | 0.1027 | 3 | 3 |
| wogonin | Homo sapiens (human) | IC50 | 12.3000 | 1 | 1 |
| alvocidib | Homo sapiens (human) | IC50 | 0.5140 | 1 | 1 |
| su 9516 | Homo sapiens (human) | IC50 | 0.9050 | 1 | 1 |
| arcyriaflavin a | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| palbociclib | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| cvt 313 | Homo sapiens (human) | IC50 | 9.2000 | 1 | 1 |
| nu 6140 | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| at 7519 | Homo sapiens (human) | IC50 | 2.4000 | 2 | 2 |
| at 7519 | Homo sapiens (human) | Ki | 2.8000 | 1 | 1 |
| pf 573228 | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| pha 848125 | Homo sapiens (human) | IC50 | 0.2700 | 1 | 1 |
| 14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene | Homo sapiens (human) | IC50 | 0.0200 | 2 | 2 |
| p276-00 | Homo sapiens (human) | IC50 | 2.8700 | 1 | 1 |
| cink4 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| ldc067 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| (R)-DRF053 | Homo sapiens (human) | IC50 | 0.8220 | 1 | 1 |
| pf 3758309 | Homo sapiens (human) | IC50 | 0.0070 | 1 | 1 |
| ribociclib | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| bay 1000394 | Homo sapiens (human) | IC50 | 0.0250 | 2 | 2 |
| abemaciclib | Homo sapiens (human) | IC50 | 3.1060 | 2 | 2 |
| abemaciclib | Homo sapiens (human) | Ki | 3.9100 | 1 | 1 |
| dinaciclib | Homo sapiens (human) | IC50 | 0.1700 | 2 | 2 |
| gilteritinib | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| longdaysin | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| bs-181 | Homo sapiens (human) | IC50 | 0.1340 | 1 | 1 |
| on123300 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| ly2857785 | Homo sapiens (human) | IC50 | 0.2460 | 1 | 1 |
| THZ531 | Homo sapiens (human) | IC50 | 8.5000 | 2 | 2 |
| ro 3306 | Homo sapiens (human) | IC50 | 17.4000 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| cyclin-dependent protein serine/threonine kinase activator activity | molecular function | Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. [GOC:dph, PMID:2569363, PMID:3322810] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
This protein is part of 5 target(s):
| Target | Category | Definition |
|---|---|---|
| cyclin-dependent protein kinase holoenzyme complex | cellular component | Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. [GOC:krc, PMID:11602261] |
| transcription factor TFIIH core complex | cellular component | The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD. [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015] |
| transcription factor TFIIH holo complex | cellular component | A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex. [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] |
| CAK-ERCC2 complex | cellular component | A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2. [PMID:8692841, PMID:8692842] |
| transcription factor TFIIK complex | cellular component | A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7. [GOC:mah, PMID:19818408, PMID:22572993] |
This protein is involved in 11 target(s):
| Target | Category | Definition |
|---|---|---|
| G1/S transition of mitotic cell cycle | biological process | The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. [GOC:mtg_cell_cycle] |
| nucleotide-excision repair | biological process | A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). [PMID:10197977] |
| regulation of transcription by RNA polymerase II | biological process | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |
| transcription initiation at RNA polymerase II promoter | biological process | A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II. [GOC:mah, GOC:txnOH] |
| adult heart development | biological process | The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. [GOC:bf] |
| ventricular system development | biological process | The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] |
| negative regulation of apoptotic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| positive regulation of smooth muscle cell proliferation | biological process | Any process that activates or increases the rate or extent of smooth muscle cell proliferation. [CL:0000192, GOC:ebc] |
| response to calcium ion | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. [GOC:ai] |
| regulation of G1/S transition of mitotic cell cycle | biological process | Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle] |
| DNA repair | biological process | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486] |