Cyclin-dependent kinase 2

A cyclin-dependent kinase 2 that is encoded in the genome of human. [PRO:DNx]

Synonyms

EC 2.7.11.22;
Cell division protein kinase 2;
p33 protein kinase

Research

Bioassay Publications (263)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (0.38)	18.2507
2000's	106 (40.30)	29.6817
2010's	122 (46.39)	24.3611
2020's	34 (12.93)	2.80

Compounds (377)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
1-anilino-8-naphthalenesulfonate	Homo sapiens (human)	IC50	91.0000	2	2
tyrphostin a23	Homo sapiens (human)	Ki	0.6166	1	1
aristolochic acid i	Homo sapiens (human)	IC50	20.0000	1	1
bisindolylmaleimide i	Homo sapiens (human)	IC50	12.2700	2	5
bisindolylmaleimide iv	Homo sapiens (human)	IC50	12.2975	2	4
bohemine	Homo sapiens (human)	IC50	1.3667	2	3
n(6),n(6)-dimethyladenine	Homo sapiens (human)	Ki	1.0965	1	1
gw8510	Homo sapiens (human)	IC50	0.0079	7	7
indirubin-3'-monoxime	Homo sapiens (human)	IC50	0.5767	3	3
indirubin-5-sulfonate	Homo sapiens (human)	IC50	4.5436	4	9
staurosporine aglycone	Homo sapiens (human)	IC50	0.9433	3	3
nsc 664704	Homo sapiens (human)	IC50	0.7300	2	2
methazolamide	Homo sapiens (human)	IC50	0.0140	1	1
nu2058	Homo sapiens (human)	IC50	14.5000	6	8
nu2058	Homo sapiens (human)	Ki	8.4400	4	5
nu6102	Homo sapiens (human)	IC50	2.0964	19	27
nu6102	Homo sapiens (human)	Ki	0.0035	2	2
o(6)-benzylguanine	Homo sapiens (human)	IC50	29.5000	2	4
olomoucine	Homo sapiens (human)	IC50	49.7861	20	23
pd 153035	Homo sapiens (human)	IC50	250.0000	1	1
1-NA-PP1	Homo sapiens (human)	IC50	9.0075	2	2
imatinib	Homo sapiens (human)	IC50	50.9480	7	14
whi p180	Homo sapiens (human)	IC50	1.0000	1	1
dichlororibofuranosylbenzimidazole	Homo sapiens (human)	Ki	65.0000	1	1
indazoles	Homo sapiens (human)	IC50	185.0000	4	4
isocorydine	Homo sapiens (human)	IC50	50.0000	1	1
corydine	Homo sapiens (human)	IC50	50.0000	1	1
indirubin	Homo sapiens (human)	IC50	3.2400	10	10
indigo	Homo sapiens (human)	IC50	35.5000	2	2
canadine	Homo sapiens (human)	IC50	50.0000	1	1
staurosporine	Homo sapiens (human)	IC50	1.6200	31	31
staurosporine	Homo sapiens (human)	Ki	0.0026	2	3
o-(6)-methylguanine	Homo sapiens (human)	IC50	100.0000	1	1
7-hydroxystaurosporine	Homo sapiens (human)	Ki	0.0625	1	2
fascaplysine	Homo sapiens (human)	IC50	375.0000	4	4
LSM-4272	Homo sapiens (human)	IC50	25.1750	1	2
5-Chloro-1H-indole-2,3-dione	Homo sapiens (human)	IC50	1,000.0000	1	1
dehydroabietic acid	Homo sapiens (human)	IC50	36.2900	1	1
o(6)-n-butylguanine	Homo sapiens (human)	IC50	42.6667	2	3
2-(4-hydroxyphenyl)-5,6,7,8-tetrahydroxy-4H-1-benzopyran-4-one	Homo sapiens (human)	IC50	150.0000	1	2
aristolactam i	Homo sapiens (human)	IC50	1.2000	1	1
dicentrine	Homo sapiens (human)	IC50	50.0000	1	1
aristolochic acid ii	Homo sapiens (human)	IC50	20.0000	1	1
cercosporamide	Homo sapiens (human)	IC50	0.7700	1	1
3',4'-dihydroxyflavone	Homo sapiens (human)	IC50	500.0000	1	1
3,3',4'-trihydroxyflavone	Homo sapiens (human)	IC50	4.0000	1	1
birb 796	Homo sapiens (human)	IC50	30.0000	2	2
cyc 202	Homo sapiens (human)	IC50	2.4849	57	66
cyc 202	Homo sapiens (human)	Ki	0.2500	1	1
corytuberine	Homo sapiens (human)	IC50	50.0000	1	1
stephanine	Homo sapiens (human)	IC50	50.0000	1	1
aristolochic acid D	Homo sapiens (human)	IC50	25.0000	1	1
aristolochic acid c	Homo sapiens (human)	IC50	30.0000	1	1
sb 216763	Homo sapiens (human)	IC50	0.2690	1	1
erlotinib	Homo sapiens (human)	IC50	1.1400	1	1
2,4-diamino-6-benzyloxy-5-nitrosopyrimidine	Homo sapiens (human)	IC50	27.0000	2	3
lapatinib	Homo sapiens (human)	IC50	15.5000	2	2
sorafenib	Homo sapiens (human)	IC50	150.0000	1	1
n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide	Homo sapiens (human)	IC50	0.0070	1	1
paullone	Homo sapiens (human)	IC50	2.7000	1	1
nu 6027	Homo sapiens (human)	IC50	2.3750	6	8
nu 6027	Homo sapiens (human)	Ki	1.6000	3	4
2H-pyrazolo[4,3-b]quinoxalin-3-amine	Homo sapiens (human)	IC50	2.8050	2	2
pd 173955	Homo sapiens (human)	IC50	0.0280	1	1
n-(4-methoxybenzyl)-n'-(5-nitro-1,3-thiazol-2-yl)urea	Homo sapiens (human)	IC50	100.0000	2	2
7-n-butyl-6-(4'-hydroxyphenyl)-5h-pyrrolo(2,3b)pyrazine	Homo sapiens (human)	IC50	0.2600	2	2
6-bromoindirubin-3'-oxime	Homo sapiens (human)	IC50	0.0415	2	2
purvalanol b	Homo sapiens (human)	IC50	0.0072	5	5
repsox	Homo sapiens (human)	IC50	100.0000	1	1
purvalanol a	Homo sapiens (human)	IC50	0.0617	13	16
2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione	Homo sapiens (human)	IC50	80.0000	3	3
cgp 60474	Homo sapiens (human)	IC50	0.0041	3	3
2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-1-benzopyran-4-one	Homo sapiens (human)	IC50	500.0000	1	1
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-naphthalenecarboxamide	Homo sapiens (human)	IC50	10.0000	1	1
cgp 74514a	Homo sapiens (human)	IC50	0.0297	3	3
1,4-dimethoxy-10H-acridine-9-thione	Homo sapiens (human)	IC50	35.0500	3	4
bms 387032	Homo sapiens (human)	IC50	3.2398	15	15
bms 387032	Homo sapiens (human)	Ki	0.0380	1	1
sf 2370	Homo sapiens (human)	IC50	0.1450	1	2
vx-745	Homo sapiens (human)	IC50	5.0000	1	1
dasatinib	Homo sapiens (human)	IC50	5.0000	2	2
sb 218078	Homo sapiens (human)	IC50	0.6333	2	3
7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine	Homo sapiens (human)	Ki	0.0005	1	1
sb 415286	Homo sapiens (human)	IC50	0.3800	1	1
alsterpaullone	Homo sapiens (human)	IC50	0.0150	2	2
1-tert-butyl-3-naphthalen-1-ylmethyl-1h-pyrazolo(3,4-d)pyrimidin-4-ylemine	Homo sapiens (human)	IC50	14.5025	2	2
quercetin	Homo sapiens (human)	IC50	40.0000	1	1
luteolin	Homo sapiens (human)	IC50	20.0000	1	1
harmine	Homo sapiens (human)	IC50	25.0000	3	3
fisetin	Homo sapiens (human)	IC50	5.0000	1	1
wogonin	Homo sapiens (human)	IC50	1.4600	2	2
ellagic acid	Homo sapiens (human)	IC50	3.3900	1	1
alvocidib	Homo sapiens (human)	IC50	8.0882	35	42
alvocidib	Homo sapiens (human)	Ki	0.1400	3	3
aftin-4	Homo sapiens (human)	IC50	556.6667	1	6
su 9516	Homo sapiens (human)	IC50	3.2733	6	9
casein kinase ii	Homo sapiens (human)	IC50	2.3800	1	1
arcyriaflavin a	Homo sapiens (human)	IC50	1.7677	9	17
su 11248	Homo sapiens (human)	IC50	130.0000	1	1
pd 0183812	Homo sapiens (human)	IC50	6.7927	3	6
palbociclib	Homo sapiens (human)	IC50	5.8436	14	15
palbociclib	Homo sapiens (human)	Ki	5.0000	1	1
jnj-7706621	Homo sapiens (human)	IC50	27.6823	4	16
salutaridine	Homo sapiens (human)	IC50	50.0000	1	1
sinomenine	Homo sapiens (human)	IC50	50.0000	1	1
olomoucine ii	Homo sapiens (human)	IC50	0.0500	1	1
2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz(h)imidazo(4,5-f)isoquinoline-7-one	Homo sapiens (human)	IC50	3.3000	1	1
vx680	Homo sapiens (human)	IC50	1.9978	1	19
cyc 116	Homo sapiens (human)	IC50	1.2200	2	4
cyc 116	Homo sapiens (human)	Ki	0.3900	2	2
gw2974	Homo sapiens (human)	IC50	8.0000	1	1
2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]ethanol	Homo sapiens (human)	IC50	8.4667	2	3
cvt 313	Homo sapiens (human)	IC50	0.1980	2	2
((3z)-n-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1h-pyrrol-2-yl)methylene)-n-methyl-2-oxo-2,3-dihydro-1h-indole-5-sulfonamide)	Homo sapiens (human)	Ki	0.4898	1	1
jnj 10198409	Homo sapiens (human)	IC50	10.0000	2	2
gw843682x	Homo sapiens (human)	IC50	7.6000	1	0
tofacitinib	Homo sapiens (human)	IC50	10.0000	2	2
ap23464	Homo sapiens (human)	IC50	13.9335	2	3
ly2090314	Homo sapiens (human)	IC50	2.8000	1	1
leucettamine b	Homo sapiens (human)	IC50	10.0000	1	1
azd2858	Homo sapiens (human)	Ki	0.5400	1	1
nu 6140	Homo sapiens (human)	IC50	136.1667	3	3
sotrastaurin	Homo sapiens (human)	IC50	2.3000	1	1
saracatinib	Homo sapiens (human)	IC50	10.0000	1	1
aristolactam aiiia	Homo sapiens (human)	IC50	0.1400	2	2
meridianin a	Homo sapiens (human)	IC50	3.1000	1	1
l 783277	Homo sapiens (human)	IC50	10.0000	1	1
rgb 286638	Homo sapiens (human)	IC50	0.0025	2	2
at 7519	Homo sapiens (human)	IC50	0.0586	10	11
at 7519	Homo sapiens (human)	Ki	0.2770	2	2
compound 26	Homo sapiens (human)	IC50	10.0000	1	1
danusertib	Homo sapiens (human)	IC50	0.4620	1	1
N-[5-[[5-[(4-acetyl-1-piperazinyl)-oxomethyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[(3,3-dimethylbutan-2-ylamino)methyl]benzamide	Homo sapiens (human)	IC50	29.0000	1	1
nvp-aew541	Homo sapiens (human)	IC50	10.0000	1	1
5-(5,6-dimethoxy-1-benzimidazolyl)-3-[(2-methylsulfonylphenyl)methoxy]-2-thiophenecarbonitrile	Homo sapiens (human)	IC50	30.0000	1	1
4-[2-(2-chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide	Homo sapiens (human)	Ki	0.5282	2	5
cgp 57380	Homo sapiens (human)	Ki	10.0000	1	1
pha 767491	Homo sapiens (human)	IC50	0.2400	1	1
5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4h-1-benzopyran-4-one	Homo sapiens (human)	IC50	7.3000	3	3
azd 1152-hqpa	Homo sapiens (human)	Ki	10.0000	1	1
2-({2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl}amino)benzamide	Homo sapiens (human)	IC50	2.7000	1	1
gsk 269962a	Homo sapiens (human)	IC50	3.5000	1	1
sb 772077-b	Homo sapiens (human)	IC50	7.0000	1	1
mk-8776	Homo sapiens (human)	IC50	0.1600	1	1
pha 848125	Homo sapiens (human)	IC50	0.2563	9	13
14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene	Homo sapiens (human)	IC50	0.0282	6	6
azd5438	Homo sapiens (human)	IC50	0.0158	4	4
p276-00	Homo sapiens (human)	IC50	1.8547	3	3
meriolin 3	Homo sapiens (human)	IC50	0.0110	3	3
cx 4945	Homo sapiens (human)	IC50	1.8000	1	1
bms 754807	Homo sapiens (human)	IC50	1.0350	1	1
pci 32765	Homo sapiens (human)	IC50	25.0000	1	1
cink4	Homo sapiens (human)	IC50	28.8000	4	4
N-cyclopropyl-3-{4-[(cyclopropylmethyl)carbamoyl]phenyl}-4-methylbenzamide	Homo sapiens (human)	IC50	20.0000	1	1
quizartinib	Homo sapiens (human)	IC50	20.0000	2	2
defactinib	Homo sapiens (human)	IC50	0.3440	1	0
bs 194	Homo sapiens (human)	IC50	0.0030	3	3
entrectinib	Homo sapiens (human)	IC50	1.0000	1	1
(R)-DRF053	Homo sapiens (human)	IC50	0.1915	2	2
N-(2-chlorophenyl)-4-[[2-[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]anilino]-5-fluoro-4-pyrimidinyl]amino]benzamide	Homo sapiens (human)	IC50	16.0000	1	1
4-[6-[4-(methoxycarbonylamino)phenyl]-4-(4-morpholinyl)-1-pyrazolo[3,4-d]pyrimidinyl]-1-piperidinecarboxylic acid methyl ester	Homo sapiens (human)	IC50	50.0000	1	1
nms p715	Homo sapiens (human)	IC50	55.0000	2	2
ribociclib	Homo sapiens (human)	IC50	36.5714	7	7
bay 1000394	Homo sapiens (human)	IC50	0.0086	7	7
pha 793887	Homo sapiens (human)	IC50	0.0080	2	2
tak-632	Homo sapiens (human)	IC50	0.5800	1	1
sb 1518	Homo sapiens (human)	IC50	3.9000	1	1
abemaciclib	Homo sapiens (human)	IC50	0.2635	8	8
abemaciclib	Homo sapiens (human)	Ki	0.5040	1	1
dinaciclib	Homo sapiens (human)	IC50	0.0074	20	20
nms p937	Homo sapiens (human)	IC50	10.0000	2	2
gilteritinib	Homo sapiens (human)	Ki	1.4850	1	1
longdaysin	Homo sapiens (human)	IC50	13.0000	1	1
nms-p118	Homo sapiens (human)	IC50	10.0000	1	1
bs-181	Homo sapiens (human)	IC50	1.1933	3	3
butyrolactone i	Homo sapiens (human)	IC50	1.5000	2	2
lfm a13	Homo sapiens (human)	IC50	500.0000	1	1
urmc-099	Homo sapiens (human)	IC50	1.1800	1	1
on123300	Homo sapiens (human)	IC50	0.1970	3	3
ceritinib	Homo sapiens (human)	IC50	3.9700	1	1
amg 925	Homo sapiens (human)	IC50	0.3750	1	1
ldc4297	Homo sapiens (human)	IC50	0.0064	1	1
THZ531	Homo sapiens (human)	IC50	1.3000	1	1
r 1530	Homo sapiens (human)	IC50	1.3300	1	1
can 508	Homo sapiens (human)	IC50	24.8412	8	17
can 508	Homo sapiens (human)	Ki	41.1500	2	2
((5z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4h-imidazol-4-one)	Homo sapiens (human)	IC50	20.0000	2	2
ro 3306	Homo sapiens (human)	IC50	0.2195	2	2
ro 3306	Homo sapiens (human)	Ki	0.3400	1	1
hymenialdisine	Homo sapiens (human)	IC50	0.0550	2	2
nintedanib	Homo sapiens (human)	IC50	5.5000	2	2
debromohymenialdisine	Homo sapiens (human)	IC50	8.6661	1	7
nms-e973	Homo sapiens (human)	IC50	0.0100	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
1-anilino-8-naphthalenesulfonate	Homo sapiens (human)	Kd	37.0000	3	3
fasudil	Homo sapiens (human)	Kd	30.0000	1	1
4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline	Homo sapiens (human)	Kd	30.0000	1	1
nu6102	Homo sapiens (human)	Kd	1.3100	1	1
sb 202190	Homo sapiens (human)	Kd	10.0000	1	1
imatinib	Homo sapiens (human)	Kd	16.6667	3	3
pyrazolanthrone	Homo sapiens (human)	Kd	3.2000	1	1
rhein	Homo sapiens (human)	Kd	9.6000	1	1
triciribine phosphate	Homo sapiens (human)	Kd	30.0000	1	1
staurosporine	Homo sapiens (human)	Kd	0.0074	3	3
picropodophyllin	Homo sapiens (human)	Kd	30.0000	1	1
gefitinib	Homo sapiens (human)	Kd	16.6667	3	3
lestaurtinib	Homo sapiens (human)	Kd	0.1233	3	3
methotrexate	Homo sapiens (human)	EC50	0.0010	1	1
perifosine	Homo sapiens (human)	Kd	30.0000	1	1
vatalanib	Homo sapiens (human)	Kd	16.6667	3	3
ruboxistaurin	Homo sapiens (human)	Kd	16.6667	3	3
canertinib	Homo sapiens (human)	Kd	16.6667	3	3
birb 796	Homo sapiens (human)	Kd	10.0000	2	2
cyc 202	Homo sapiens (human)	EC50	0.1510	1	1
cyc 202	Homo sapiens (human)	Kd	12.1000	3	3
sb 203580	Homo sapiens (human)	Kd	10.0000	2	2
enzastaurin	Homo sapiens (human)	Kd	17.5000	2	2
erlotinib	Homo sapiens (human)	Kd	16.6667	3	3
lapatinib	Homo sapiens (human)	Kd	16.6667	3	3
sorafenib	Homo sapiens (human)	Kd	14.6750	4	4
pd 173955	Homo sapiens (human)	Kd	10.0000	1	1
s 1033	Homo sapiens (human)	Kd	20.0000	2	2
xl147	Homo sapiens (human)	Kd	30.0000	1	1
bms 387032	Homo sapiens (human)	Kd	0.1143	3	3
sf 2370	Homo sapiens (human)	Kd	0.1010	1	1
tandutinib	Homo sapiens (human)	Kd	15.0000	4	4
vx-745	Homo sapiens (human)	Kd	10.0000	2	2
dasatinib	Homo sapiens (human)	Kd	16.6667	3	3
ha 1100	Homo sapiens (human)	Kd	30.0000	1	1
7-epi-hydroxystaurosporine	Homo sapiens (human)	Kd	30.0000	1	1
zd 6474	Homo sapiens (human)	Kd	16.6667	3	3
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide	Homo sapiens (human)	Kd	10.0000	1	1
imd 0354	Homo sapiens (human)	Kd	30.0000	1	1
butein	Homo sapiens (human)	Kd	100.0000	1	1
sirolimus	Homo sapiens (human)	Kd	30.0000	1	1
alvocidib	Homo sapiens (human)	Kd	0.6592	4	4
bosutinib	Homo sapiens (human)	Kd	20.0000	2	2
orantinib	Homo sapiens (human)	Kd	30.0000	1	1
su 11248	Homo sapiens (human)	Kd	14.0000	5	5
palbociclib	Homo sapiens (human)	Kd	30.0000	1	1
jnj-7706621	Homo sapiens (human)	Kd	0.0230	1	1
vx680	Homo sapiens (human)	Kd	16.6667	3	3
cyc 116	Homo sapiens (human)	Kd	4.2320	1	1
everolimus	Homo sapiens (human)	Kd	30.0000	1	1
ekb 569	Homo sapiens (human)	Kd	20.0000	2	2
axitinib	Homo sapiens (human)	Kd	20.0000	2	2
temsirolimus	Homo sapiens (human)	Kd	30.0000	1	1
pd 184352	Homo sapiens (human)	Kd	10.0000	1	1
on 01910	Homo sapiens (human)	Kd	30.0000	1	1
av 412	Homo sapiens (human)	Kd	30.0000	1	1
telatinib	Homo sapiens (human)	Kd	30.0000	1	1
y-39983	Homo sapiens (human)	Kd	30.0000	1	1
cp 547632	Homo sapiens (human)	Kd	30.0000	1	1
bms345541	Homo sapiens (human)	Kd	10.0000	1	1
lenvatinib	Homo sapiens (human)	Kd	30.0000	1	1
pd 0325901	Homo sapiens (human)	Kd	30.0000	1	1
midostaurin	Homo sapiens (human)	Kd	15.0000	4	4
px-866	Homo sapiens (human)	Kd	30.0000	1	1
ripasudil	Homo sapiens (human)	Kd	30.0000	1	1
osi 930	Homo sapiens (human)	Kd	30.0000	1	1
ki 20227	Homo sapiens (human)	Kd	10.0000	1	1
scio-469	Homo sapiens (human)	Kd	30.0000	1	1
cp 724714	Homo sapiens (human)	Kd	20.0000	2	2
pi103	Homo sapiens (human)	Kd	10.0000	2	2
hmn-214	Homo sapiens (human)	Kd	30.0000	1	1
tivozanib	Homo sapiens (human)	Kd	30.0000	1	1
hki 272	Homo sapiens (human)	Kd	20.0000	2	2
tofacitinib	Homo sapiens (human)	Kd	16.6667	3	3
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide	Homo sapiens (human)	Kd	10.0000	1	1
cediranib	Homo sapiens (human)	Kd	20.0000	2	2
masitinib	Homo sapiens (human)	Kd	20.0000	2	2
ly-2157299	Homo sapiens (human)	Kd	30.0000	1	1
pazopanib	Homo sapiens (human)	Kd	16.6667	3	3
azd 6244	Homo sapiens (human)	Kd	20.0000	2	2
su 14813	Homo sapiens (human)	Kd	16.6667	3	3
bibw 2992	Homo sapiens (human)	Kd	20.0000	2	2
pik 75	Homo sapiens (human)	Kd	0.5400	1	1
binimetinib	Homo sapiens (human)	Kd	30.0000	1	1
sotrastaurin	Homo sapiens (human)	Kd	30.0000	1	1
aee 788	Homo sapiens (human)	Kd	30.0000	1	1
saracatinib	Homo sapiens (human)	Kd	30.0000	1	1
vx 702	Homo sapiens (human)	Kd	30.0000	1	1
crenolanib	Homo sapiens (human)	Kd	0.1280	1	1
tg100-115	Homo sapiens (human)	Kd	23.3333	2	3
cc 401	Homo sapiens (human)	Kd	30.0000	1	1
bms 599626	Homo sapiens (human)	Kd	30.0000	1	1
exel-7647	Homo sapiens (human)	Kd	30.0000	1	1
volasertib	Homo sapiens (human)	Kd	30.0000	1	1
pha 665752	Homo sapiens (human)	Kd	10.0000	1	1
azd 7762	Homo sapiens (human)	Kd	30.0000	1	1
regorafenib	Homo sapiens (human)	Kd	30.0000	1	1
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one	Homo sapiens (human)	Kd	20.0000	2	2
brivanib	Homo sapiens (human)	Kd	20.0000	2	2
mp470	Homo sapiens (human)	Kd	30.0000	1	1
rgb 286638	Homo sapiens (human)	Kd	0.0720	1	1
np 031112	Homo sapiens (human)	Kd	30.0000	1	1
at 7519	Homo sapiens (human)	Kd	0.0995	2	2
bms-690514	Homo sapiens (human)	Kd	30.0000	1	1
bi 2536	Homo sapiens (human)	Kd	20.0000	2	2
inno-406	Homo sapiens (human)	Kd	30.0000	1	1
nvp-ast487	Homo sapiens (human)	Kd	0.6050	2	2
kw 2449	Homo sapiens (human)	Kd	20.0000	2	2
danusertib	Homo sapiens (human)	Kd	30.0000	1	1
abt 869	Homo sapiens (human)	Kd	16.6667	3	3
azd 8931	Homo sapiens (human)	Kd	30.0000	1	1
arq 197	Homo sapiens (human)	Kd	30.0000	1	1
azd 1152	Homo sapiens (human)	Kd	30.0000	1	1
pf 00299804	Homo sapiens (human)	Kd	30.0000	1	1
ridaforolimus	Homo sapiens (human)	Kd	30.0000	1	1
ch 4987655	Homo sapiens (human)	Kd	30.0000	1	1
6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-n-(2,2-dimethylprpyl)-3-pyridinecarboxamide	Homo sapiens (human)	Kd	30.0000	1	1
cc-930	Homo sapiens (human)	Kd	30.0000	1	1
gw 2580	Homo sapiens (human)	Kd	10.0000	2	2
tak 285	Homo sapiens (human)	Kd	30.0000	1	1
idelalisib	Homo sapiens (human)	Kd	30.0000	1	1
crizotinib	Homo sapiens (human)	Kd	20.0000	2	2
osi 906	Homo sapiens (human)	Kd	30.0000	1	1
chir-265	Homo sapiens (human)	Kd	16.6667	3	3
motesanib	Homo sapiens (human)	Kd	16.6667	3	3
fostamatinib	Homo sapiens (human)	Kd	30.0000	1	2
trametinib	Homo sapiens (human)	Kd	30.0000	1	1
mln8054	Homo sapiens (human)	Kd	16.6667	3	3
pf-562,271	Homo sapiens (human)	Kd	1.0730	1	1
GDC-0879	Homo sapiens (human)	Kd	10.0000	1	1
jnj-26483327	Homo sapiens (human)	Kd	30.0000	1	1
ly2603618	Homo sapiens (human)	Kd	30.0000	1	1
tg100801	Homo sapiens (human)	Kd	30.0000	1	1
dactolisib	Homo sapiens (human)	Kd	30.0000	1	1
bgt226	Homo sapiens (human)	Kd	30.0000	1	1
gsk 461364	Homo sapiens (human)	Kd	20.0000	2	2
azd 1152-hqpa	Homo sapiens (human)	Kd	16.6667	3	3
nvp-tae684	Homo sapiens (human)	Kd	5.2000	1	1
enmd 2076	Homo sapiens (human)	Kd	30.0000	1	1
e 7050	Homo sapiens (human)	Kd	30.0000	1	1
2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinone	Homo sapiens (human)	Kd	30.0000	1	1
tak-901	Homo sapiens (human)	Kd	30.0000	1	2
gdc-0973	Homo sapiens (human)	Kd	30.0000	1	1
buparlisib	Homo sapiens (human)	Kd	30.0000	1	1
azd 1480	Homo sapiens (human)	Kd	30.0000	1	1
azd8330	Homo sapiens (human)	Kd	30.0000	1	1
pha 848125	Homo sapiens (human)	Kd	0.7390	1	1
ro5126766	Homo sapiens (human)	Kd	30.0000	1	1
fedratinib	Homo sapiens (human)	Kd	20.0000	2	2
gsk690693	Homo sapiens (human)	Kd	20.0000	2	2
14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene	Homo sapiens (human)	Kd	0.2430	1	1
azd5438	Homo sapiens (human)	Kd	0.7210	1	1
pf 04217903	Homo sapiens (human)	Kd	30.0000	1	1
gdc 0941	Homo sapiens (human)	Kd	20.0000	2	2
icotinib	Homo sapiens (human)	Kd	30.0000	1	1
ph 797804	Homo sapiens (human)	Kd	30.0000	1	1
kx-01	Homo sapiens (human)	Kd	30.0000	1	1
plx 4720	Homo sapiens (human)	Kd	10.0000	1	1
mk 5108	Homo sapiens (human)	Kd	30.0000	1	1
cx 4945	Homo sapiens (human)	Kd	1.6880	1	1
cudc 101	Homo sapiens (human)	Kd	30.0000	1	1
arry-614	Homo sapiens (human)	Kd	30.0000	1	1
tak 593	Homo sapiens (human)	Kd	30.0000	1	1
mln 8237	Homo sapiens (human)	Kd	30.0000	1	1
sgx 523	Homo sapiens (human)	Kd	20.0000	2	2
bms 754807	Homo sapiens (human)	Kd	30.0000	1	1
bms 777607	Homo sapiens (human)	Kd	30.0000	1	1
sgi 1776	Homo sapiens (human)	Kd	30.0000	1	1
pci 32765	Homo sapiens (human)	Kd	30.0000	1	2
ponatinib	Homo sapiens (human)	Kd	30.0000	1	1
amg 900	Homo sapiens (human)	Kd	30.0000	1	2
mk-1775	Homo sapiens (human)	Kd	30.0000	1	1
AMG-208	Homo sapiens (human)	Kd	30.0000	1	1
quizartinib	Homo sapiens (human)	Kd	16.6667	3	3
at13148	Homo sapiens (human)	Kd	30.0000	1	2
tak 733	Homo sapiens (human)	Kd	30.0000	1	1
mk 2206	Homo sapiens (human)	Kd	30.0000	1	1
sns 314	Homo sapiens (human)	Kd	30.0000	1	1
lucitanib	Homo sapiens (human)	Kd	30.0000	1	1
pf-04691502	Homo sapiens (human)	Kd	30.0000	1	1
n-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide	Homo sapiens (human)	Kd	2.1130	1	1
dcc-2036	Homo sapiens (human)	Kd	0.1990	1	1
cabozantinib	Homo sapiens (human)	Kd	30.0000	1	1
defactinib	Homo sapiens (human)	Kd	1.6560	1	1
ly2584702	Homo sapiens (human)	Kd	30.0000	1	1
incb-018424	Homo sapiens (human)	Kd	20.0000	2	2
poziotinib	Homo sapiens (human)	Kd	30.0000	1	1
asp3026	Homo sapiens (human)	Kd	30.0000	1	1
entrectinib	Homo sapiens (human)	Kd	30.0000	1	1
pexidartinib	Homo sapiens (human)	Kd	30.0000	1	1
TAK-580	Homo sapiens (human)	Kd	30.0000	1	1
gsk 2126458	Homo sapiens (human)	Kd	30.0000	1	1
emd1214063	Homo sapiens (human)	Kd	30.0000	1	1
gsk 1838705a	Homo sapiens (human)	Kd	10.0000	1	1
pf 3758309	Homo sapiens (human)	Kd	30.0000	1	1
gdc 0980	Homo sapiens (human)	Kd	30.0000	1	1
azd2014	Homo sapiens (human)	Kd	30.0000	1	1
(5-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol	Homo sapiens (human)	Kd	30.0000	1	2
plx4032	Homo sapiens (human)	Kd	30.0000	1	1
gsk 1363089	Homo sapiens (human)	Kd	20.0000	2	2
arry-334543	Homo sapiens (human)	Kd	30.0000	1	1
kin-193	Homo sapiens (human)	Kd	30.0000	1	1
mk 2461	Homo sapiens (human)	Kd	30.0000	1	1
bay 869766	Homo sapiens (human)	Kd	30.0000	1	1
as 703026	Homo sapiens (human)	Kd	30.0000	1	1
baricitinib	Homo sapiens (human)	Kd	30.0000	1	1
dabrafenib	Homo sapiens (human)	Kd	0.0190	1	1
pki 587	Homo sapiens (human)	Kd	30.0000	1	1
n-(3-fluoro-4-((1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5 yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide	Homo sapiens (human)	Kd	30.0000	1	1
ribociclib	Homo sapiens (human)	Kd	30.0000	1	1
mk-8033	Homo sapiens (human)	Kd	30.0000	1	1
pha 793887	Homo sapiens (human)	Kd	0.0980	1	1
sb 1518	Homo sapiens (human)	Kd	30.0000	1	1
abemaciclib	Homo sapiens (human)	Kd	10.4870	1	1
mk-8776	Homo sapiens (human)	Kd	30.0000	1	1
afuresertib	Homo sapiens (human)	Kd	30.0000	1	1
gsk 1070916	Homo sapiens (human)	Kd	30.0000	1	1
jnj38877605	Homo sapiens (human)	Kd	30.0000	1	1
dinaciclib	Homo sapiens (human)	Kd	0.0542	2	2
gilteritinib	Homo sapiens (human)	Kd	30.0000	1	1
alectinib	Homo sapiens (human)	Kd	30.0000	1	1
glpg0634	Homo sapiens (human)	Kd	30.0000	1	1
encorafenib	Homo sapiens (human)	Kd	30.0000	1	2
bms-911543	Homo sapiens (human)	Kd	30.0000	1	1
gsk2141795	Homo sapiens (human)	Kd	30.0000	1	1
azd8186	Homo sapiens (human)	Kd	30.0000	1	1
byl719	Homo sapiens (human)	Kd	30.0000	1	1
cep-32496	Homo sapiens (human)	Kd	30.0000	1	1
rociletinib	Homo sapiens (human)	Kd	30.0000	1	1
ceritinib	Homo sapiens (human)	Kd	30.0000	1	1
azd1208	Homo sapiens (human)	Kd	30.0000	1	1
vx-509	Homo sapiens (human)	Kd	30.0000	1	1
debio 1347	Homo sapiens (human)	Kd	30.0000	1	1
volitinib	Homo sapiens (human)	Kd	30.0000	1	1
osimertinib	Homo sapiens (human)	Kd	30.0000	1	1
at 9283	Homo sapiens (human)	Kd	30.0000	1	1
otssp167	Homo sapiens (human)	Kd	0.0910	1	1
chir 258	Homo sapiens (human)	Kd	16.6667	3	3
osi 027	Homo sapiens (human)	Kd	30.0000	1	1
nintedanib	Homo sapiens (human)	Kd	15.7000	2	2
bay 80-6946	Homo sapiens (human)	Kd	30.0000	1	1
pp242	Homo sapiens (human)	Kd	10.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
olomoucine	Homo sapiens (human)	ID50	7.0000	1	1
cyc 202	Homo sapiens (human)	INH	24.5000	1	1
purvalanol b	Homo sapiens (human)	ID50	0.0075	2	2
cgp 60474	Homo sapiens (human)	ID50	0.0500	1	1
alvocidib	Homo sapiens (human)	Cell cycle	0.0210	10	10
alvocidib	Homo sapiens (human)	ID50	0.1000	1	1
olomoucine ii	Homo sapiens (human)	INH	11.4000	1	1

Enables

This protein enables 9 target(s):

Target	Category	Definition
magnesium ion binding	molecular function	Binding to a magnesium (Mg) ion. [GOC:ai]
protein serine/threonine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]
cyclin-dependent protein serine/threonine kinase activity	molecular function	Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
protein domain specific binding	molecular function	Binding to a specific domain of a protein. [GOC:go_curators]
cyclin binding	molecular function	Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. [GOC:ai]
cyclin-dependent protein kinase activity	molecular function	Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [GOC:pr]
protein serine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]

Located In

This protein is located in 13 target(s):

Target	Category	Definition
chromosome, telomeric region	cellular component	The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). [GOC:elh]
condensed chromosome	cellular component	A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. [GOC:elh]
X chromosome	cellular component	The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males. [GOC:mah, GOC:mr, ISBN:0582227089, PMID:20622855, Wikipedia:XY_sex-determination_system]
Y chromosome	cellular component	The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males. [GOC:mah, GOC:mr, ISBN:0582227089, PMID:20622855, Wikipedia:XY_sex-determination_system]
male germ cell nucleus	cellular component	The nucleus of a male germ cell, a reproductive cell in males. [CL:0000015, GOC:hjd, GOC:mtg_sensu]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nuclear envelope	cellular component	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). [ISBN:0198547684]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
endosome	cellular component	A vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]
centrosome	cellular component	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
Cajal body	cellular component	A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 6 target(s):

Target	Category	Definition
cyclin A1-CDK2 complex	cellular component	A protein complex consisting of cyclin A1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]
cyclin A2-CDK2 complex	cellular component	A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]
cyclin E1-CDK2 complex	cellular component	A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]
cyclin E2-CDK2 complex	cellular component	A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]
cyclin-dependent protein kinase holoenzyme complex	cellular component	Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. [GOC:krc, PMID:11602261]
transcription regulator complex	cellular component	A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. [GOC:jl]

Involved In

This protein is involved in 31 target(s):

Target	Category	Definition
G1/S transition of mitotic cell cycle	biological process	The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. [GOC:mtg_cell_cycle]
G2/M transition of mitotic cell cycle	biological process	The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. [GOC:mtg_cell_cycle]
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
DNA replication	biological process	The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. [GOC:mah]
DNA repair	biological process	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]
chromatin remodeling	biological process	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
DNA-templated transcription	biological process	The synthesis of an RNA transcript from a DNA template. [GOC:jl, GOC:txnOH]
protein phosphorylation	biological process	The process of introducing a phosphate group on to a protein. [GOC:hb]
potassium ion transport	biological process	The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
centriole replication	biological process	The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0. [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]
Ras protein signal transduction	biological process	An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal. [GOC:bf]
regulation of mitotic cell cycle	biological process	Any process that modulates the rate or extent of progress through the mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]
positive regulation of cell population proliferation	biological process	Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
peptidyl-serine phosphorylation	biological process	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. [RESID:AA0037]
positive regulation of heterochromatin formation	biological process	Any process that activates or increases the frequency, rate or extent of heterochromatin formation. [GOC:mah]
mitotic G1 DNA damage checkpoint signaling	biological process	A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint. [GOC:mtg_cell_cycle]
positive regulation of DNA-templated DNA replication initiation	biological process	Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication. [GOC:mah]
telomere maintenance in response to DNA damage	biological process	Any process that occur in response to the presence of critically short or damaged telomeres. [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:15279784]
post-translational protein modification	biological process	The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. [GOC:jsg]
positive regulation of DNA replication	biological process	Any process that activates or increases the frequency, rate or extent of DNA replication. [GOC:go_curators]
positive regulation of DNA-templated transcription	biological process	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
centrosome duplication	biological process	The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. [GOC:ai]
cell division	biological process	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr]
meiotic cell cycle	biological process	Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. [GOC:ai]
cellular response to nitric oxide	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. [GOC:mah, GOC:yaf]
cellular senescence	biological process	A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. [GOC:BHF, PMID:28682291]
regulation of anaphase-promoting complex-dependent catabolic process	biological process	Any process that modulates the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:10921876]
regulation of G2/M transition of mitotic cell cycle	biological process	Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. [GOC:mtg_cell_cycle, PMID:17329565]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
regulation of gene expression	biological process	Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
response to organic substance	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. [GOC:sm, PMID:23356676]