Page last updated: 2024-08-07 16:15:52
G1/S-specific cyclin-D1
A G1/S-specific cyclin-D1 that is encoded in the genome of human. [PRO:DNx]
Synonyms
B-cell lymphoma 1 protein;
BCL-1;
BCL-1 oncogene;
PRAD1 oncogene
Research
Bioassay Publications (74)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.35) | 18.2507 |
| 2000's | 31 (41.89) | 29.6817 |
| 2010's | 29 (39.19) | 24.3611 |
| 2020's | 13 (17.57) | 2.80 |
Compounds (70)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| bisindolylmaleimide i | Homo sapiens (human) | IC50 | 10.4320 | 2 | 5 |
| bisindolylmaleimide iv | Homo sapiens (human) | IC50 | 10.8275 | 2 | 4 |
| gw8510 | Homo sapiens (human) | IC50 | 0.1390 | 1 | 1 |
| indirubin-3'-monoxime | Homo sapiens (human) | IC50 | 3.3300 | 1 | 1 |
| indirubin-5-sulfonate | Homo sapiens (human) | IC50 | 0.3000 | 2 | 2 |
| staurosporine aglycone | Homo sapiens (human) | IC50 | 0.8300 | 3 | 3 |
| nu6102 | Homo sapiens (human) | IC50 | 0.2598 | 2 | 8 |
| nu6102 | Homo sapiens (human) | Ki | 1.6000 | 1 | 1 |
| olomoucine | Homo sapiens (human) | IC50 | 602.8000 | 3 | 5 |
| triamterene | Homo sapiens (human) | IC50 | 210.0000 | 1 | 1 |
| indirubin | Homo sapiens (human) | IC50 | 12.0000 | 3 | 3 |
| staurosporine | Homo sapiens (human) | IC50 | 0.0355 | 13 | 13 |
| staurosporine | Homo sapiens (human) | Ki | 0.0410 | 1 | 1 |
| 7-hydroxystaurosporine | Homo sapiens (human) | Ki | 3.6000 | 1 | 1 |
| fascaplysine | Homo sapiens (human) | IC50 | 0.5033 | 3 | 3 |
| LSM-4272 | Homo sapiens (human) | IC50 | 25.1750 | 1 | 2 |
| 7h-pyrido(4,3-c)carbazole | Homo sapiens (human) | IC50 | 159.0000 | 2 | 2 |
| cyc 202 | Homo sapiens (human) | IC50 | 32.0700 | 6 | 6 |
| sb 216763 | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| sorafenib | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| 2H-pyrazolo[4,3-b]quinoxalin-3-amine | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| 7-n-butyl-6-(4'-hydroxyphenyl)-5h-pyrrolo(2,3b)pyrazine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 6-bromoindirubin-3'-oxime | Homo sapiens (human) | IC50 | 0.5270 | 1 | 1 |
| purvalanol b | Homo sapiens (human) | IC50 | 10.0000 | 2 | 2 |
| purvalanol a | Homo sapiens (human) | IC50 | 0.8500 | 4 | 4 |
| 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione | Homo sapiens (human) | IC50 | 7.7500 | 2 | 2 |
| cgp 60474 | Homo sapiens (human) | IC50 | 0.2160 | 1 | 1 |
| cgp 74514a | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| 1,4-dimethoxy-10H-acridine-9-thione | Homo sapiens (human) | IC50 | 40.0667 | 2 | 3 |
| bms 387032 | Homo sapiens (human) | IC50 | 0.9250 | 3 | 3 |
| sf 2370 | Homo sapiens (human) | IC50 | 0.1450 | 1 | 2 |
| sb 218078 | Homo sapiens (human) | IC50 | 0.5750 | 3 | 4 |
| quercetin | Homo sapiens (human) | IC50 | 61.0000 | 1 | 1 |
| genistein | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| ellagic acid | Homo sapiens (human) | IC50 | 1.0900 | 1 | 1 |
| alvocidib | Homo sapiens (human) | IC50 | 0.1837 | 18 | 25 |
| su 9516 | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| (E)-3-(2-Hydroxyphenyl)-2-propenal | Homo sapiens (human) | IC50 | 35.0000 | 2 | 2 |
| granulatimide | Homo sapiens (human) | IC50 | 0.7400 | 1 | 1 |
| arcyriaflavin a | Homo sapiens (human) | IC50 | 1.5939 | 9 | 17 |
| pd 0183812 | Homo sapiens (human) | IC50 | 8.0780 | 2 | 5 |
| palbociclib | Homo sapiens (human) | IC50 | 0.2490 | 20 | 21 |
| palbociclib | Homo sapiens (human) | Ki | 0.0030 | 1 | 1 |
| jnj-7706621 | Homo sapiens (human) | IC50 | 0.1100 | 1 | 1 |
| vx680 | Homo sapiens (human) | IC50 | 0.0006 | 1 | 1 |
| cyc 116 | Homo sapiens (human) | IC50 | 1.7000 | 1 | 2 |
| cvt 313 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| zm 447439 | Homo sapiens (human) | IC50 | 0.0390 | 1 | 1 |
| nu 6140 | Homo sapiens (human) | IC50 | 0.9400 | 1 | 1 |
| rgb 286638 | Homo sapiens (human) | IC50 | 0.0020 | 1 | 1 |
| at 7519 | Homo sapiens (human) | IC50 | 0.1168 | 4 | 4 |
| at 7519 | Homo sapiens (human) | Ki | 0.0670 | 1 | 1 |
| nvp-aew541 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| pha 848125 | Homo sapiens (human) | IC50 | 0.1600 | 4 | 4 |
| p276-00 | Homo sapiens (human) | IC50 | 0.0630 | 3 | 3 |
| cink4 | Homo sapiens (human) | IC50 | 5.7500 | 2 | 2 |
| ldc067 | Homo sapiens (human) | IC50 | 3.1600 | 1 | 1 |
| bs 194 | Homo sapiens (human) | IC50 | 27.7500 | 2 | 2 |
| (R)-DRF053 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| ribociclib | Homo sapiens (human) | IC50 | 0.0235 | 6 | 6 |
| bay 1000394 | Homo sapiens (human) | IC50 | 0.0110 | 4 | 4 |
| pha 793887 | Homo sapiens (human) | IC50 | 0.0620 | 1 | 1 |
| abemaciclib | Homo sapiens (human) | IC50 | 0.0048 | 6 | 6 |
| abemaciclib | Homo sapiens (human) | Ki | 0.0042 | 3 | 3 |
| dinaciclib | Homo sapiens (human) | IC50 | 0.1190 | 3 | 3 |
| nms p937 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| bs-181 | Homo sapiens (human) | IC50 | 44.7000 | 1 | 1 |
| butyrolactone i | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| on123300 | Homo sapiens (human) | IC50 | 0.0089 | 4 | 4 |
| sr-3029 | Homo sapiens (human) | IC50 | 0.5015 | 2 | 0 |
| amg 925 | Homo sapiens (human) | IC50 | 0.0030 | 1 | 1 |
| [4-amino-2-[2-methoxy-4-(4-methyl-1-piperazinyl)anilino]-5-thiazolyl]-(2,6-dichlorophenyl)methanone | Homo sapiens (human) | IC50 | 0.9020 | 2 | 2 |
| can 508 | Homo sapiens (human) | IC50 | 24.9812 | 3 | 8 |
| pteroic acid | Homo sapiens (human) | IC50 | 16.0000 | 1 | 1 |
| ro 3306 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| alvocidib | Homo sapiens (human) | ID50 | 0.4000 | 1 | 1 |
Enables
This protein enables 9 target(s):
| Target | Category | Definition |
|---|---|---|
| transcription corepressor activity | molecular function | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867] |
| protein kinase activity | molecular function | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| enzyme binding | molecular function | Binding to an enzyme, a protein with catalytic activity. [GOC:jl] |
| protein kinase binding | molecular function | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl] |
| histone deacetylase binding | molecular function | Binding to histone deacetylase. [GOC:jl] |
| cyclin-dependent protein serine/threonine kinase activator activity | molecular function | Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. [GOC:dph, PMID:2569363, PMID:3322810] |
| proline-rich region binding | molecular function | Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein. [GOC:mah] |
| cyclin-dependent protein serine/threonine kinase regulator activity | molecular function | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| bicellular tight junction | cellular component | An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. [GOC:mah, ISBN:0815332181] |
| nuclear membrane | cellular component | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz] |
Active In
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| centrosome | cellular component | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
Part Of
This protein is part of 4 target(s):
| Target | Category | Definition |
|---|---|---|
| cyclin D1-CDK4 complex | cellular component | A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619] |
| cyclin D1-CDK6 complex | cellular component | A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619] |
| cyclin-dependent protein kinase holoenzyme complex | cellular component | Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. [GOC:krc, PMID:11602261] |
| transcription repressor complex | cellular component | A protein complex that possesses activity that prevents or downregulates transcription. [GOC:mah] |
Involved In
This protein is involved in 25 target(s):
| Target | Category | Definition |
|---|---|---|
| G1/S transition of mitotic cell cycle | biological process | The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. [GOC:mtg_cell_cycle] |
| negative regulation of transcription by RNA polymerase II | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |
| re-entry into mitotic cell cycle | biological process | The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state. [GOC:krc] |
| positive regulation of protein phosphorylation | biological process | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd] |
| DNA damage response | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. [GOC:go_curators] |
| lactation | biological process | The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. [ISBN:0198506732] |
| response to xenobiotic stimulus | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc] |
| positive regulation of G2/M transition of mitotic cell cycle | biological process | Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. [GOC:dph, GOC:mtg_cell_cycle, GOC:tb] |
| Wnt signaling pathway | biological process | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state. [PMID:11532397] |
| neuron differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of a neuron. [GOC:mah] |
| negative regulation of epithelial cell differentiation | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. [GOC:mah] |
| endoplasmic reticulum unfolded protein response | biological process | The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. [GOC:mah, PMID:12042763] |
| mitotic G1 DNA damage checkpoint signaling | biological process | A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint. [GOC:mtg_cell_cycle] |
| mammary gland epithelial cell proliferation | biological process | The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph, GOC:mah] |
| positive regulation of mammary gland epithelial cell proliferation | biological process | Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation. [GOC:mah] |
| negative regulation of neuron apoptotic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis] |
| response to leptin | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]. [GOC:yaf] |
| fat cell differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. [CL:0000136, GOC:go_curators] |
| positive regulation of cyclin-dependent protein serine/threonine kinase activity | biological process | Any process that activates or increases the frequency, rate or extent of CDK activity. [GOC:go_curators, GOC:pr] |
| cell division | biological process | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr] |
| mammary gland alveolus development | biological process | The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland. [GOC:dph] |
| response to UV-A | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm. [GOC:BHF, GOC:mah] |
| liver regeneration | biological process | The regrowth of lost or destroyed liver. [GOC:gap, PMID:19447520] |
| positive regulation of G1/S transition of mitotic cell cycle | biological process | Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle] |
| regulation of cyclin-dependent protein serine/threonine kinase activity | biological process | Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. [GOC:go_curators, GOC:pr] |