G1/S-specific cyclin-D1

A G1/S-specific cyclin-D1 that is encoded in the genome of human. [PRO:DNx]

Synonyms

B-cell lymphoma 1 protein;
BCL-1;
BCL-1 oncogene;
PRAD1 oncogene

Research

Bioassay Publications (74)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (1.35)	18.2507
2000's	31 (41.89)	29.6817
2010's	29 (39.19)	24.3611
2020's	13 (17.57)	2.80

Compounds (70)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bisindolylmaleimide i	Homo sapiens (human)	IC50	10.4320	2	5
bisindolylmaleimide iv	Homo sapiens (human)	IC50	10.8275	2	4
gw8510	Homo sapiens (human)	IC50	0.1390	1	1
indirubin-3'-monoxime	Homo sapiens (human)	IC50	3.3300	1	1
indirubin-5-sulfonate	Homo sapiens (human)	IC50	0.3000	2	2
staurosporine aglycone	Homo sapiens (human)	IC50	0.8300	3	3
nu6102	Homo sapiens (human)	IC50	0.2598	2	8
nu6102	Homo sapiens (human)	Ki	1.6000	1	1
olomoucine	Homo sapiens (human)	IC50	602.8000	3	5
triamterene	Homo sapiens (human)	IC50	210.0000	1	1
indirubin	Homo sapiens (human)	IC50	12.0000	3	3
staurosporine	Homo sapiens (human)	IC50	0.0355	13	13
staurosporine	Homo sapiens (human)	Ki	0.0410	1	1
7-hydroxystaurosporine	Homo sapiens (human)	Ki	3.6000	1	1
fascaplysine	Homo sapiens (human)	IC50	0.5033	3	3
LSM-4272	Homo sapiens (human)	IC50	25.1750	1	2
7h-pyrido(4,3-c)carbazole	Homo sapiens (human)	IC50	159.0000	2	2
cyc 202	Homo sapiens (human)	IC50	32.0700	6	6
sb 216763	Homo sapiens (human)	IC50	32.0000	1	1
sorafenib	Homo sapiens (human)	IC50	3.0000	1	1
2H-pyrazolo[4,3-b]quinoxalin-3-amine	Homo sapiens (human)	IC50	20.0000	1	1
7-n-butyl-6-(4'-hydroxyphenyl)-5h-pyrrolo(2,3b)pyrazine	Homo sapiens (human)	IC50	100.0000	1	1
6-bromoindirubin-3'-oxime	Homo sapiens (human)	IC50	0.5270	1	1
purvalanol b	Homo sapiens (human)	IC50	10.0000	2	2
purvalanol a	Homo sapiens (human)	IC50	0.8500	4	4
2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione	Homo sapiens (human)	IC50	7.7500	2	2
cgp 60474	Homo sapiens (human)	IC50	0.2160	1	1
cgp 74514a	Homo sapiens (human)	IC50	3.0000	1	1
1,4-dimethoxy-10H-acridine-9-thione	Homo sapiens (human)	IC50	40.0667	2	3
bms 387032	Homo sapiens (human)	IC50	0.9250	3	3
sf 2370	Homo sapiens (human)	IC50	0.1450	1	2
sb 218078	Homo sapiens (human)	IC50	0.5750	3	4
quercetin	Homo sapiens (human)	IC50	61.0000	1	1
genistein	Homo sapiens (human)	IC50	250.0000	1	1
ellagic acid	Homo sapiens (human)	IC50	1.0900	1	1
alvocidib	Homo sapiens (human)	IC50	0.1837	18	25
su 9516	Homo sapiens (human)	IC50	1.7000	1	1
(E)-3-(2-Hydroxyphenyl)-2-propenal	Homo sapiens (human)	IC50	35.0000	2	2
granulatimide	Homo sapiens (human)	IC50	0.7400	1	1
arcyriaflavin a	Homo sapiens (human)	IC50	1.5939	9	17
pd 0183812	Homo sapiens (human)	IC50	8.0780	2	5
palbociclib	Homo sapiens (human)	IC50	0.2490	20	21
palbociclib	Homo sapiens (human)	Ki	0.0030	1	1
jnj-7706621	Homo sapiens (human)	IC50	0.1100	1	1
vx680	Homo sapiens (human)	IC50	0.0006	1	1
cyc 116	Homo sapiens (human)	IC50	1.7000	1	2
cvt 313	Homo sapiens (human)	IC50	20.0000	1	1
zm 447439	Homo sapiens (human)	IC50	0.0390	1	1
nu 6140	Homo sapiens (human)	IC50	0.9400	1	1
rgb 286638	Homo sapiens (human)	IC50	0.0020	1	1
at 7519	Homo sapiens (human)	IC50	0.1168	4	4
at 7519	Homo sapiens (human)	Ki	0.0670	1	1
nvp-aew541	Homo sapiens (human)	IC50	10.0000	1	1
pha 848125	Homo sapiens (human)	IC50	0.1600	4	4
p276-00	Homo sapiens (human)	IC50	0.0630	3	3
cink4	Homo sapiens (human)	IC50	5.7500	2	2
ldc067	Homo sapiens (human)	IC50	3.1600	1	1
bs 194	Homo sapiens (human)	IC50	27.7500	2	2
(R)-DRF053	Homo sapiens (human)	IC50	20.0000	1	1
ribociclib	Homo sapiens (human)	IC50	0.0235	6	6
bay 1000394	Homo sapiens (human)	IC50	0.0110	4	4
pha 793887	Homo sapiens (human)	IC50	0.0620	1	1
abemaciclib	Homo sapiens (human)	IC50	0.0048	6	6
abemaciclib	Homo sapiens (human)	Ki	0.0042	3	3
dinaciclib	Homo sapiens (human)	IC50	0.1190	3	3
nms p937	Homo sapiens (human)	IC50	10.0000	1	1
bs-181	Homo sapiens (human)	IC50	44.7000	1	1
butyrolactone i	Homo sapiens (human)	IC50	1,000.0000	1	1
on123300	Homo sapiens (human)	IC50	0.0089	4	4
sr-3029	Homo sapiens (human)	IC50	0.5015	2	0
amg 925	Homo sapiens (human)	IC50	0.0030	1	1
[4-amino-2-[2-methoxy-4-(4-methyl-1-piperazinyl)anilino]-5-thiazolyl]-(2,6-dichlorophenyl)methanone	Homo sapiens (human)	IC50	0.9020	2	2
can 508	Homo sapiens (human)	IC50	24.9812	3	8
pteroic acid	Homo sapiens (human)	IC50	16.0000	1	1
ro 3306	Homo sapiens (human)	IC50	20.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
alvocidib	Homo sapiens (human)	ID50	0.4000	1	1

Enables

This protein enables 9 target(s):

Target	Category	Definition
transcription corepressor activity	molecular function	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
protein kinase activity	molecular function	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
protein kinase binding	molecular function	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
histone deacetylase binding	molecular function	Binding to histone deacetylase. [GOC:jl]
cyclin-dependent protein serine/threonine kinase activator activity	molecular function	Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. [GOC:dph, PMID:2569363, PMID:3322810]
proline-rich region binding	molecular function	Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein. [GOC:mah]
cyclin-dependent protein serine/threonine kinase regulator activity	molecular function	Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
bicellular tight junction	cellular component	An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. [GOC:mah, ISBN:0815332181]
nuclear membrane	cellular component	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
centrosome	cellular component	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 4 target(s):

Target	Category	Definition
cyclin D1-CDK4 complex	cellular component	A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]
cyclin D1-CDK6 complex	cellular component	A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]
cyclin-dependent protein kinase holoenzyme complex	cellular component	Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. [GOC:krc, PMID:11602261]
transcription repressor complex	cellular component	A protein complex that possesses activity that prevents or downregulates transcription. [GOC:mah]

Involved In

This protein is involved in 25 target(s):

Target	Category	Definition
G1/S transition of mitotic cell cycle	biological process	The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. [GOC:mtg_cell_cycle]
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
re-entry into mitotic cell cycle	biological process	The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state. [GOC:krc]
positive regulation of protein phosphorylation	biological process	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
DNA damage response	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. [GOC:go_curators]
lactation	biological process	The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. [ISBN:0198506732]
response to xenobiotic stimulus	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
positive regulation of G2/M transition of mitotic cell cycle	biological process	Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. [GOC:dph, GOC:mtg_cell_cycle, GOC:tb]
Wnt signaling pathway	biological process	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state. [PMID:11532397]
neuron differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a neuron. [GOC:mah]
negative regulation of epithelial cell differentiation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. [GOC:mah]
endoplasmic reticulum unfolded protein response	biological process	The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. [GOC:mah, PMID:12042763]
mitotic G1 DNA damage checkpoint signaling	biological process	A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint. [GOC:mtg_cell_cycle]
mammary gland epithelial cell proliferation	biological process	The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph, GOC:mah]
positive regulation of mammary gland epithelial cell proliferation	biological process	Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation. [GOC:mah]
negative regulation of neuron apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis]
response to leptin	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]. [GOC:yaf]
fat cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. [CL:0000136, GOC:go_curators]
positive regulation of cyclin-dependent protein serine/threonine kinase activity	biological process	Any process that activates or increases the frequency, rate or extent of CDK activity. [GOC:go_curators, GOC:pr]
cell division	biological process	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr]
mammary gland alveolus development	biological process	The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland. [GOC:dph]
response to UV-A	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm. [GOC:BHF, GOC:mah]
liver regeneration	biological process	The regrowth of lost or destroyed liver. [GOC:gap, PMID:19447520]
positive regulation of G1/S transition of mitotic cell cycle	biological process	Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]
regulation of cyclin-dependent protein serine/threonine kinase activity	biological process	Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. [GOC:go_curators, GOC:pr]