Proteins > Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
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Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
[no definition available]
Synonyms
Cam-PDE 1A;
EC 3.1.4.17;
61 kDa Cam-PDE
Research
Bioassay Publications (14)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 4 (28.57) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (17)
Drugs with Inhibition Measurements
Synthesis and antibronchospastic activity of 8-alkoxy- and 8-(alkylamino)imidazo[1,2-a]pyrazines.Journal of medicinal chemistry, , Sep-04, Volume: 35, Issue:18, 1992
3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonists.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Mesoionic xanthine analogues: phosphodiesterase inhibitory and hypotensive activity.Journal of medicinal chemistry, , Volume: 24, Issue:6, 1981
Benz-fused mesoionic xanthine analogues as inhibitors of cyclic-AMP phosphodiesterase.Journal of medicinal chemistry, , Volume: 24, Issue:6, 1981
Identification of purine inhibitors of phosphodiesterase 7 (PDE7).Bioorganic & medicinal chemistry letters, , Jun-07, Volume: 14, Issue:11, 2004
Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues.Journal of medicinal chemistry, , Volume: 32, Issue:7, 1989
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.Journal of medicinal chemistry, , Oct-09, Volume: 46, Issue:21, 2003
Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 15, Issue:11, 2005
Identification of purine inhibitors of phosphodiesterase 7 (PDE7).Bioorganic & medicinal chemistry letters, , Jun-07, Volume: 14, Issue:11, 2004
Synthesis and phosphodiesterase 5 inhibitory activity of new sildenafil analogues containing a phosphonate group in the 5(')-sulfonamide moiety of phenyl ring.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues.Journal of medicinal chemistry, , Oct-09, Volume: 46, Issue:21, 2003
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues.Journal of medicinal chemistry, , Oct-09, Volume: 46, Issue:21, 2003
Imidazo[5,1-f]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors.Bioorganic & medicinal chemistry letters, , Mar-25, Volume: 12, Issue:6, 2002
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues.Journal of medicinal chemistry, , Oct-09, Volume: 46, Issue:21, 2003
Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.Journal of medicinal chemistry, , Sep-01, Volume: 38, Issue:18, 1995