An M-phase inducer phosphatase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30305]
EC 3.1.3.48;
Dual specificity phosphatase Cdc25B
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 9 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone | Homo sapiens (human) | IC50 | 17.2650 | 2 | 2 |
| 2,3-dimethoxy-1,4-naphthoquinone | Homo sapiens (human) | IC50 | 17.4000 | 1 | 1 |
| juglone | Homo sapiens (human) | IC50 | 1.9800 | 1 | 1 |
| lapachol | Homo sapiens (human) | IC50 | 42.7000 | 1 | 1 |
| vitamin k 3 | Homo sapiens (human) | IC50 | 3.1600 | 3 | 3 |
| quinone | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| 9,10-anthraquinone | Homo sapiens (human) | IC50 | 9.5100 | 1 | 1 |
| 1-naphthylphenylamine | Homo sapiens (human) | Ki | 32.0000 | 1 | 1 |
| 1,4-naphthoquinone | Homo sapiens (human) | IC50 | 2.7600 | 1 | 1 |
| naphthazarin | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| plumbagin | Homo sapiens (human) | IC50 | 3.1000 | 1 | 1 |
| oleanolic acid | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| 2-methoxy-1,4-naphthoquinone | Homo sapiens (human) | IC50 | 46.8000 | 1 | 1 |
| buparvaquone | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| illimaquinone | Homo sapiens (human) | IC50 | 92.0000 | 1 | 1 |
| ortho-(1-naphthoyl)benzoic acid | Homo sapiens (human) | Ki | 69.0000 | 1 | 1 |
| 6,7-dichloroquinoline-5,8-dione | Homo sapiens (human) | IC50 | 4.6000 | 1 | 1 |
| pinocembrin | Homo sapiens (human) | IC50 | 36.7300 | 1 | 1 |
| nsc 95397 | Homo sapiens (human) | IC50 | 7.1908 | 6 | 6 |
| nsc 663284 | Homo sapiens (human) | IC50 | 26.3020 | 5 | 5 |
| nsc 663284 | Homo sapiens (human) | Ki | 0.0950 | 1 | 1 |
| nsc668394 | Homo sapiens (human) | IC50 | 17.8200 | 2 | 2 |
| shikonin | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| 2-[[5-(3-chlorophenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]thio]-1-(3,4-dihydroxyphenyl)ethanone | Homo sapiens (human) | IC50 | 4.6700 | 1 | 1 |
| tocopherylquinone | Homo sapiens (human) | IC50 | 23.2300 | 1 | 1 |
| dysidiolide | Homo sapiens (human) | IC50 | 87.0000 | 1 | 1 |
| rk 682 | Homo sapiens (human) | IC50 | 12.4000 | 1 | 1 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| phosphoprotein phosphatase activity | molecular function | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. [ISBN:0198547684] |
| protein tyrosine phosphatase activity | molecular function | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| protein kinase binding | molecular function | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| spindle pole | cellular component | Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. [GOC:clt] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| centrosome | cellular component | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 11 target(s):
| Target | Category | Definition |
|---|---|---|
| G2/M transition of mitotic cell cycle | biological process | The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. [GOC:mtg_cell_cycle] |
| mitotic cell cycle | biological process | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. [GOC:mah, ISBN:0815316194, Reactome:69278] |
| oocyte maturation | biological process | A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/] |
| protein phosphorylation | biological process | The process of introducing a phosphate group on to a protein. [GOC:hb] |
| female meiosis I | biological process | The cell cycle process in which the first meiotic division occurs in the female germline. [GOC:mah] |
| positive regulation of cell population proliferation | biological process | Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators] |
| positive regulation of G2/M transition of mitotic cell cycle | biological process | Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. [GOC:dph, GOC:mtg_cell_cycle, GOC:tb] |
| positive regulation of cytokinesis | biological process | Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. [GOC:mah] |
| positive regulation of mitotic cell cycle | biological process | Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb] |
| cell division | biological process | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr] |
| positive regulation of G2/MI transition of meiotic cell cycle | biological process | Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle. [GOC:vw, PMID:25492408] |