Page last updated: 2024-08-01 08:18:28
linoleic acid
Description
Linoleic Acid: A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed) [MeSH]
linoleic acid : An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry. [CHeBI]
Cross-References
Synonyms (186)
| Synonym |
|---|
| 9,12-octadecadienoic acid, (z,z)-, labeled with carbon-14 |
| 80969-37-5 |
| 14c-linoleic acid |
| (14c)-linoleic acid |
| (14c)alpha-linolenic acid |
| BRD-K08973992-001-03-9 |
| c18:2 |
| gtpl1052 |
| all-cis-9,12-octadecadienoic acid |
| CHEBI:17351 , |
| cis,cis-linoleic acid |
| (9z,12z)-octadeca-9,12-dienoic acid |
| c18:2 9c, 12c omega6 todos cis-9,12-octadienoico |
| acide linoleique |
| cis,cis-9,12-octadecadienoic acid |
| cis-delta(9,12)-octadecadienoic acid |
| c18:2, n-6,9 all-cis |
| linolic acid |
| acido linoleico |
| acide cis-linoleique |
| 9z,12z-octadecadienoic acid |
| 9,12-octadecadienoic acid (z,z)- |
| 9,12-octadecadienoic acid (9z,12z)- |
| bdbm22231 |
| chembl267476 , |
| LIN , |
| ACON1_000270 |
| linoleic |
| nsc281243 |
| vespula pensylvanica b708568k063 |
| leinoleic acid |
| cis,12-octadecadienoic acid |
| nsc-281243 |
| emersol 315 |
| cis-9,cis-12-octadecadienoic acid |
| telfairic acid |
| 9,12-linoleic acid |
| 9,z)- |
| unifac 6550 |
| 9, (z)- |
| emersol 310 |
| IDI1_033844 |
| BSPBIO_001374 |
| NCGC00091049-01 |
| ai3-11132 |
| hsdb 5200 |
| alpha-linoleic acid |
| ccris 650 |
| nsc 281243 |
| cis-delta9,12-octadecadienoic acid |
| linoleic acid, pure |
| einecs 200-470-9 |
| (z,z)-9,12-octadecadienoic acid |
| 9-cis,12-cis-linoleic acid |
| 9,12-octadecadienoic acid, (z,z)- |
| extra linoleic 90 |
| (9z,12z)-octadecadienoic acid |
| C01595 |
| linoleic acid |
| 9-cis,12-cis-octadecadienoate |
| 9-cis,12-cis-octadecadienoic acid |
| 60-33-3 |
| linoleic acid, >=99% |
| linoleic acid, liquid, bioreagent, suitable for cell culture |
| linoleic acid, >=93% (gc) |
| linoleic acid, >=95% |
| cis-9, cis-12-octadecadienoic acid |
| 9z,12z-linoleic acid |
| leinolic acid |
| LMFA01030120 |
| NCGC00091049-04 |
| NCGC00091049-03 |
| NCGC00091049-02 |
| NCGC00091049-05 |
| NCGC00091049-06 |
| acid, 9,12-octadecadienoic |
| 9,12 octadecadienoic acid |
| linoleic acid, technical, 60-74% (gc) |
| CHEBI:137735 |
| HMS1989E16 |
| 5CE5E1F3-8859-4C5B-9AFE-E44A7076DF6E |
| ronacare asc 3 |
| fema no. 3380, linoleic acid- |
| c18:2 (n-6) |
| BML3-C03 |
| HMS1791E16 |
| HMS1361E16 |
| BMSE000497 |
| BMSE000604 |
| L0053 |
| L0124 |
| A832696 |
| cis,cis-9,12-octadecadienoic acid; linoleate; emersol315; linoleic; unifac6550; |
| NCGC00091049-07 |
| unii-9kjl21t0qj |
| 9kjl21t0qj , |
| dtxcid505505 |
| cas-60-33-3 |
| tox21_303080 |
| dtxsid2025505 , |
| NCGC00257024-01 |
| NCGC00259720-01 |
| tox21_202171 |
| tox21_111067 |
| AKOS015951293 |
| 9,12-octadecadienoic acid (van) |
| delta9,12-octadecadienoic acid |
| ai3-36448 |
| 9,12-octadecadienoic acid, (e,e)- |
| ccris 652 |
| unii-7552p0k6pn |
| (9z,12z)-9,12-octadecadienoic-1-13c acid |
| 85594-37-2 |
| 8016-21-5 |
| vitamin f component linoleic acid |
| linoleic acid (constituent of saw palmetto) [dsc] |
| linoleic acid [vandf] |
| linoleic acid [fcc] |
| linoleic acid [hsdb] |
| linoleic acid [who-dd] |
| linoleic acid [mi] |
| linoleic acid [inci] |
| linoleic acid [mart.] |
| linoleic acid (constituent of spirulina) [dsc] |
| n-6,9 all-cis |
| EPITOPE ID:117705 |
| 12c omega6 todos cis-9,12-octadienoico |
| c18:2 9c |
| S5821 |
| SCHEMBL7067 |
| cis-.delta.9,12-octadecadienoic acid |
| pamolyn 125 (salt/mix) |
| octadeca-9,12-dienoic acid, (cis,cis)- |
| (z,z)-octadeca-9, 12-dienoic acid |
| 9,12-octadecadienoic acid, cis,cis- |
| 9-(z), 12-(z)-octadecadienoic acid |
| AC-33770 |
| HMS3649F07 |
| HMS3402E16 |
| (9z,12z)-9,12-octadecadienoic acid |
| mfcd00064241 |
| linoleic acid, 95% |
| cis-9,cis-12-octadecadienoic acid, |
| sr-01000944790 |
| SR-01000944790-1 |
| linoleic acid, analytical standard |
| linoleic acid, 2.0 mg/ml in ethanol, certified reference material |
| linoleic acid, >=95%, fg |
| linoleic acid, puriss., 90% |
| 9-cis,12-cis-linoleate |
| all-cis-9,12-octadecadienoate |
| (z,z)-9,12-octadecadienoate |
| (9z,12z)-9,12-octadecadienoate |
| linolate |
| cis-d9,12-octadecadienoic acid |
| cis-d9,12-octadecadienoate |
| 9z,12z-octadecadienoate |
| cis-9,cis-12-octadecadienoate |
| 9z,12z-linoleate |
| Q407426 |
| DB14104 |
| AS-12672 |
| SR-01000944790-3 |
| HY-N0729 |
| CS-0009742 |
| HMS3886F05 |
| linoleic-acid |
| acidelinoleique |
| cis,cis-octadeca-9,12-dienoic acid |
| BP-31121 |
| fa(18:2(9z,12z)) |
| 30175-49-6 |
| EN300-383983 |
| fatty acid 18:2 n-6 |
| polyin no.515 |
| polylin no 515 |
| cis, cis-octadeca-9,12-dienoic acid |
| linoleic acid (constituent of spirulina) |
| linoleic acid (constituent of flax seed oil) |
| (z)-9,12-octadecadienoic acid |
| linoleic acid (c18:2) (constituent of krill oil) |
| linoleic acid (constituent of borage seed oil) |
| linoleic acid (mart.) |
| linoleic acid (constituent of saw palmetto) |
| 9,12-octadecadienoic acid, (z)- |
| cis,cis,9,12-octadecadienoic acid |
Roles (3)
| Role | Description |
|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| Daphnia galeata metabolite | A Daphnia metabolite produced by the species Daphnia galeata. |
| algal metabolite | Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae. |
Drug Classes (2)
| Class | Description |
|---|
| octadecadienoic acid | Any straight-chain, C18 polyunsaturated fatty acid having two C=C double bonds. |
| omega-6 fatty acid | A family of polyunsaturated fatty acids that have in common a final carbon-carbon double bond in the n-6 position, i.e., the sixth bond from the methyl end of the fatty acid. |
Pathways (417)
linoleic acid is involved in 417 pathway(s), involving a total of 4128 unique proteins and 7162 unique compounds
| Pathway | Proteins | Compounds |
|---|
| Metabolism | 1496 | 1108 |
| Metabolism of lipids | 500 | 463 |
| Fatty acid metabolism | 113 | 203 |
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 10 | 41 |
| Linoleic acid (LA) metabolism | 5 | 24 |
| Alpha Linolenic Acid and Linoleic Acid Metabolism | 5 | 17 |
| Triacylglycerol Degradation TG(16:0/16:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(16:0/18:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/18:1(9Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/18:1(11Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/18:2(9Z,12Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(16:0/18:2(9Z,12Z)/18:0) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/18:2(9Z,12Z)/18:1(9Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/18:2(9Z,12Z)/18:1(11Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/18:2(9Z,12Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(16:0/18:2(9Z,12Z)/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/18:2(9Z,12Z)/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/18:2(9Z,12Z)/20:0) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/18:2(9Z,12Z)/20:1(11Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/18:2(9Z,12Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(16:0/18:2(9Z,12Z)/22:0) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/18:2(9Z,12Z)/22:1(13Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/18:3(6Z,9Z,12Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/18:3(9Z,12Z,15Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/20:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/20:1(11Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/20:1(13Z)/18:2(9Z,12Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(16:0/22:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(16:0/22:1(13Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/16:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/18:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:0/18:1(9Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/18:1(11Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/18:2(9Z,12Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:0/18:2(9Z,12Z)/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:0/18:2(9Z,12Z)/18:1(9Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/18:2(9Z,12Z)/18:1(11Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/18:2(9Z,12Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:0/18:2(9Z,12Z)/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/18:2(9Z,12Z)/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/18:2(9Z,12Z)/20:0) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/18:2(9Z,12Z)/20:1(11Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/18:2(9Z,12Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:0/18:2(9Z,12Z)/22:0) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/18:2(9Z,12Z)/22:1(13Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/18:3(6Z,9Z,12Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/18:3(9Z,12Z,15Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/20:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/20:1(11Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/20:1(13Z)/18:2(9Z,12Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(18:0/22:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:0/22:1(13Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(9Z)/16:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:1(9Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:1(11Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:2(9Z,12Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:2(9Z,12Z)/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:2(9Z,12Z)/18:1(9Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:2(9Z,12Z)/18:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:2(9Z,12Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:2(9Z,12Z)/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:2(9Z,12Z)/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:2(9Z,12Z)/20:0) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:2(9Z,12Z)/20:1(11Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:2(9Z,12Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:2(9Z,12Z)/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:2(9Z,12Z)/22:1(13Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:3(6Z,9Z,12Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(9Z)/18:3(9Z,12Z,15Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(9Z)/20:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(9Z)/20:1(11Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(9Z)/20:1(13Z)/18:2(9Z,12Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(18:1(9Z)/22:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(9Z)/22:1(13Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(11Z)/16:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:1(9Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:1(11Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:2(9Z,12Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:2(9Z,12Z)/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:2(9Z,12Z)/18:1(9Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:2(9Z,12Z)/18:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:2(9Z,12Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:2(9Z,12Z)/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:2(9Z,12Z)/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:2(9Z,12Z)/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:2(9Z,12Z)/20:1(11Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:2(9Z,12Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:2(9Z,12Z)/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:2(9Z,12Z)/22:1(13Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:3(6Z,9Z,12Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(11Z)/18:3(9Z,12Z,15Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(11Z)/20:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(11Z)/20:1(11Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(11Z)/20:1(13Z)/18:2(9Z,12Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(18:1(11Z)/22:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:1(11Z)/22:1(13Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/16:0/16:0) | 5 | 11 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/16:0/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/16:0/18:1(9Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/16:0/18:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/16:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/16:0/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/16:0/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/16:0/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/16:0/20:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/16:0/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/16:0/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/16:0/22:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:0/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:0/18:0) | 5 | 11 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:0/18:1(9Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:0/18:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:0/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:0/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:0/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:0/20:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:0/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:0/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:0/22:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(9Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(9Z)/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(9Z)/18:1(9Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(9Z)/18:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(9Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(9Z)/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(9Z)/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(9Z)/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(9Z)/20:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(9Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(9Z)/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(9Z)/22:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(11Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(11Z)/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(11Z)/18:1(9Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(11Z)/18:1(11Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(11Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(11Z)/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(11Z)/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(11Z)/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(11Z)/20:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(11Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(11Z)/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:1(11Z)/22:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:2(9Z,12Z)/16:0) | 5 | 11 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:2(9Z,12Z)/18:0) | 5 | 11 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:2(9Z,12Z)/18:1(9Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:2(9Z,12Z)/18:1(11Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:2(9Z,12Z)/18:2(9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:2(9Z,12Z)/18:3(6Z,9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:2(9Z,12Z)/18:3(9Z,12Z,15Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:2(9Z,12Z)/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:2(9Z,12Z)/20:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:2(9Z,12Z)/20:1(13Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:2(9Z,12Z)/22:0) | 5 | 11 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:2(9Z,12Z)/22:1(13Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(6Z,9Z,12Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(6Z,9Z,12Z)/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(6Z,9Z,12Z)/18:1(9Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(6Z,9Z,12Z)/18:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(6Z,9Z,12Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(6Z,9Z,12Z)/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(6Z,9Z,12Z)/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(6Z,9Z,12Z)/20:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(6Z,9Z,12Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(6Z,9Z,12Z)/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(6Z,9Z,12Z)/22:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)/18:1(9Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)/18:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)/18:3(9Z,12Z,15Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)/20:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)/22:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:0/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:0/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:0/18:1(9Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:0/18:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:0/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:0/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:0/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:0/20:1(11Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:0/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:0/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:0/22:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(11Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(11Z)/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(11Z)/18:1(9Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(11Z)/18:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(11Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(11Z)/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(11Z)/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(11Z)/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(11Z)/20:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(11Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(11Z)/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(11Z)/22:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(13Z)/16:0) | 5 | 9 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(13Z)/18:0) | 5 | 9 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(13Z)/18:1(9Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(13Z)/18:1(11Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(13Z)/18:2(9Z,12Z)) | 5 | 8 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(13Z)/18:3(6Z,9Z,12Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(13Z)/18:3(9Z,12Z,15Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(13Z)/20:0) | 5 | 9 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(13Z)/20:1(11Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(13Z)/20:1(13Z)) | 5 | 8 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(13Z)/22:0) | 5 | 9 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/20:1(13Z)/22:1(13Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:0/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:0/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:0/18:1(9Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:0/18:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:0/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:0/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:0/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:0/20:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:0/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:0/22:0) | 5 | 11 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:0/22:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:1(13Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:1(13Z)/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:1(13Z)/18:1(9Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:1(13Z)/18:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:1(13Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:1(13Z)/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:1(13Z)/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:1(13Z)/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:1(13Z)/20:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:1(13Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:1(13Z)/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:2(9Z,12Z)/22:1(13Z)/22:1(13Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/16:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:1(9Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:1(11Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:2(9Z,12Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:2(9Z,12Z)/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:2(9Z,12Z)/18:1(9Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:2(9Z,12Z)/18:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:2(9Z,12Z)/18:2(9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:2(9Z,12Z)/18:3(6Z,9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:2(9Z,12Z)/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:2(9Z,12Z)/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:2(9Z,12Z)/20:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:2(9Z,12Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:2(9Z,12Z)/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:2(9Z,12Z)/22:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/18:2(9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/18:3(9Z,12Z,15Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/20:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/20:1(11Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/20:1(13Z)/18:2(9Z,12Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/22:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(6Z,9Z,12Z)/22:1(13Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/16:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:1(9Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:1(11Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:2(9Z,12Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:2(9Z,12Z)/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:2(9Z,12Z)/18:1(9Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:2(9Z,12Z)/18:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:2(9Z,12Z)/18:2(9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:2(9Z,12Z)/18:3(6Z,9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:2(9Z,12Z)/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:2(9Z,12Z)/20:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:2(9Z,12Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:2(9Z,12Z)/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:2(9Z,12Z)/22:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:3(6Z,9Z,12Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:3(9Z,12Z,15Z)/18:2(9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/20:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/20:1(11Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/20:1(13Z)/18:2(9Z,12Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/22:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/22:1(13Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(20:0/16:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:0/18:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:0/18:1(9Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:0/18:1(11Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:0/18:2(9Z,12Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(20:0/18:2(9Z,12Z)/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(20:0/18:2(9Z,12Z)/18:1(9Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:0/18:2(9Z,12Z)/18:1(11Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:0/18:2(9Z,12Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(20:0/18:2(9Z,12Z)/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:0/18:2(9Z,12Z)/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:0/18:2(9Z,12Z)/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(20:0/18:2(9Z,12Z)/20:1(11Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:0/18:2(9Z,12Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(20:0/18:2(9Z,12Z)/22:0) | 5 | 13 |
| Triacylglycerol Degradation TG(20:0/18:2(9Z,12Z)/22:1(13Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:0/18:3(6Z,9Z,12Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:0/18:3(9Z,12Z,15Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:0/20:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(20:0/20:1(11Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:0/20:1(13Z)/18:2(9Z,12Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(20:0/22:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:0/22:1(13Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:1(11Z)/16:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:1(9Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:1(11Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:2(9Z,12Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:2(9Z,12Z)/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:2(9Z,12Z)/18:1(9Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:2(9Z,12Z)/18:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:2(9Z,12Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:2(9Z,12Z)/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:2(9Z,12Z)/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:2(9Z,12Z)/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:2(9Z,12Z)/20:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:2(9Z,12Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:2(9Z,12Z)/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:2(9Z,12Z)/22:1(13Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:3(6Z,9Z,12Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:1(11Z)/18:3(9Z,12Z,15Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:1(11Z)/20:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:1(11Z)/20:1(11Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(20:1(11Z)/20:1(13Z)/18:2(9Z,12Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(20:1(11Z)/22:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:1(11Z)/22:1(13Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(20:1(13Z)/16:0/18:2(9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:0/18:2(9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:1(9Z)/18:2(9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:1(11Z)/18:2(9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:2(9Z,12Z)/16:0) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:2(9Z,12Z)/18:0) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:2(9Z,12Z)/18:1(9Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:2(9Z,12Z)/18:1(11Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:2(9Z,12Z)/18:2(9Z,12Z)) | 5 | 10 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:2(9Z,12Z)/18:3(6Z,9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:2(9Z,12Z)/18:3(9Z,12Z,15Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:2(9Z,12Z)/20:0) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:2(9Z,12Z)/20:1(11Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:2(9Z,12Z)/20:1(13Z)) | 5 | 10 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:2(9Z,12Z)/22:0) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:2(9Z,12Z)/22:1(13Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:3(6Z,9Z,12Z)/18:2(9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/18:3(9Z,12Z,15Z)/18:2(9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/20:0/18:2(9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/20:1(11Z)/18:2(9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/20:1(13Z)/18:2(9Z,12Z)) | 5 | 8 |
| Triacylglycerol Degradation TG(20:1(13Z)/22:0/18:2(9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(20:1(13Z)/22:1(13Z)/18:2(9Z,12Z)) | 5 | 11 |
| Triacylglycerol Degradation TG(22:0/16:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:0/18:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:0/18:1(9Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:0/18:1(11Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:0/18:2(9Z,12Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(22:0/18:2(9Z,12Z)/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(22:0/18:2(9Z,12Z)/18:1(9Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:0/18:2(9Z,12Z)/18:1(11Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:0/18:2(9Z,12Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(22:0/18:2(9Z,12Z)/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:0/18:2(9Z,12Z)/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:0/18:2(9Z,12Z)/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(22:0/18:2(9Z,12Z)/20:1(11Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:0/18:2(9Z,12Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(22:0/18:2(9Z,12Z)/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(22:0/18:2(9Z,12Z)/22:1(13Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:0/18:3(6Z,9Z,12Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:0/18:3(9Z,12Z,15Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:0/20:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:0/20:1(11Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:0/20:1(13Z)/18:2(9Z,12Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(22:0/22:0/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(22:0/22:1(13Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:1(13Z)/16:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:1(9Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:1(11Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:2(9Z,12Z)/16:0) | 5 | 12 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:2(9Z,12Z)/18:0) | 5 | 12 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:2(9Z,12Z)/18:1(9Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:2(9Z,12Z)/18:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:2(9Z,12Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:2(9Z,12Z)/18:3(6Z,9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:2(9Z,12Z)/18:3(9Z,12Z,15Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:2(9Z,12Z)/20:0) | 5 | 12 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:2(9Z,12Z)/20:1(11Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:2(9Z,12Z)/20:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:2(9Z,12Z)/22:0) | 5 | 12 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:2(9Z,12Z)/22:1(13Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:3(6Z,9Z,12Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:1(13Z)/18:3(9Z,12Z,15Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:1(13Z)/20:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:1(13Z)/20:1(11Z)/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:1(13Z)/20:1(13Z)/18:2(9Z,12Z)) | 5 | 9 |
| Triacylglycerol Degradation TG(22:1(13Z)/22:0/18:2(9Z,12Z)) | 5 | 13 |
| Triacylglycerol Degradation TG(22:1(13Z)/22:1(13Z)/18:2(9Z,12Z)) | 5 | 12 |
| Triacylglycerol Degradation TG(18:3(9Z,12Z,15Z)/18:2(9Z,12Z)/18:3(9Z,12Z,15Z)) | 5 | 12 |
| Metabolism of alpha-linolenic acid | 6 | 15 |
| Omega-3 / omega-6 fatty acid synthesis | 0 | 38 |
| Linoleic acid metabolism affected by SARS-CoV-2 | 5 | 13 |
| Linoleic acid oxylipin metabolism | 0 | 13 |
| Mitochondrial beta-oxidation | 0 | 64 |
| Elongation of (very) long chain fatty acids | 3 | 45 |
| Octadecanoid formation from linoleic acid | 0 | 28 |
| Folic acid network | 0 | 70 |
| AtMetExpress overview | 0 | 109 |
| Selenium micronutrient network | 0 | 95 |
| Omega-3 and omega-6 unsaturated fatty acids biosynthesis pathway | 0 | 14 |
| 9-LOX and 9-HPL pathway | 0 | 3 |
| 13-LOX and 13-HPL pathway | 0 | 8 |
| Divinyl ether biosynthesis II (13-LOX) | 0 | 4 |
Protein Targets (80)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) |
|---|
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 56.2341 | AID485290 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | AID893 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | AID893 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 78.3431 | AID1224835 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 89.3584 | AID1347397 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 0.1585 | AID887 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 61.1440 | AID1224846 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 75.7083 | AID1159521 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 33.7354 | AID1346859; AID1346924 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 56.2341 | AID504865 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 33.7354 | AID1346859; AID1346924 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 23.6269 | AID1259369; AID1259392 |
| AR protein | Homo sapiens (human) | Potency | 17.9981 | AID588516; AID743035; AID743036; AID743042; AID743054; AID743063 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 60.1373 | AID1346978 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 17.7828 | AID1030 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 31.6228 | AID926; AID938 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 42.3970 | AID1259377; AID1259378 |
| progesterone receptor | Homo sapiens (human) | Potency | 31.4536 | AID1346784; AID1346795 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 39.8960 | AID720691; AID720692 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 30.8520 | AID1159552; AID1159555 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 36.3071 | AID1159527; AID1159531; AID588544; AID588546 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 54.0150 | AID1224849; AID1259403 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 32.4106 | AID588526; AID743217 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 60.6340 | AID1346982 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 33.7616 | AID588513; AID743069; AID743075; AID743078 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 31.6228 | AID588534 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 37.0103 | AID588536; AID588537; AID743094; AID743140; AID743191 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 12.3013 | AID743222 |
| caspase-3 | Homo sapiens (human) | Potency | 60.1373 | AID1346978 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 61.1306 | AID743083 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 45.7918 | AID1159516; AID1159519 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 31.2926 | AID1159509 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 46.1500 | AID1159526; AID1159528 |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 8.9125 | AID894 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 59.8896 | AID743065; AID743067 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 46.8010 | AID743210; AID743228 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 61.1306 | AID743202; AID743219 |
| geminin | Homo sapiens (human) | Potency | 26.6086 | AID624296 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 26.6795 | AID588579 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | AID884; AID885 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 28.1838 | AID504327 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.1778 | AID1487 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 68.2181 | AID651631; AID720552 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Potency | 36.4261 | AID651778 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 31.6228 | AID885 |
Inhibition Measurements
Activation Measurements
Bioassays (189)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
ISSN: 1464-3405 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3
ISSN: 1872-9096 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
ISSN: 2472-5560 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
ISSN: 1521-0111 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
ISSN: 1521-0111 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID504749 | qHTS profiling for inhibitors of Plasmodium falciparum proliferation | 2011 | Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
ISSN: 1095-9203 | Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. |
| AID1346679 | Human K2P10.1 (Two P domain potassium channels) | 2000 | The Journal of biological chemistry, Sep-15, Volume: 275, Issue:37
ISSN: 0021-9258 | Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. |
| AID1346800 | Human Peroxisome proliferator-activated receptor-gamma (1C. Peroxisome proliferator-activated receptors) | 2004 | European journal of biochemistry, Jan, Volume: 271, Issue:2
ISSN: 0014-2956 | Binding analyses between Human PPARgamma-LBD and ligands. |
| AID1346678 | Human Kv2.1 (Voltage-gated potassium channels) | 2001 | American journal of physiology. Cell physiology, Oct, Volume: 281, Issue:4
ISSN: 0363-6143 | Linoleic acid both enhances activation and blocks Kv1.5 and Kv2.1 channels by two separate mechanisms. |
| AID1346729 | Human Hepatocyte nuclear factor-4-alpha (2A. Hepatocyte nuclear factor-4 receptors) | 2009 | PloS one, , Volume: 4, Issue:5
ISSN: 1932-6203 | Identification of an endogenous ligand bound to a native orphan nuclear receptor. |
| AID1345809 | Human FFA1 receptor (Free fatty acid receptors) | 2003 | The Journal of biological chemistry, Mar-28, Volume: 278, Issue:13
ISSN: 0021-9258 | The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. |
| AID1345809 | Human FFA1 receptor (Free fatty acid receptors) | 2003 | Nature, Mar-13, Volume: 422, Issue:6928
ISSN: 0028-0836 | Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. |
| AID1346800 | Human Peroxisome proliferator-activated receptor-gamma (1C. Peroxisome proliferator-activated receptors) | 2001 | European journal of pharmacology, Apr-06, Volume: 417, Issue:1-2
ISSN: 0014-2999 | Binding of prostaglandins to human PPARgamma: tool assessment and new natural ligands. |
| AID1345188 | Human FFA4 receptor (Free fatty acid receptors) | 2006 | British journal of pharmacology, Jul, Volume: 148, Issue:5
ISSN: 0007-1188 | Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. |
| AID1345809 | Human FFA1 receptor (Free fatty acid receptors) | 2003 | Biochemical and biophysical research communications, Feb-07, Volume: 301, Issue:2
ISSN: 0006-291X | A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. |
| AID1083120 | Nematicidal activity against second-stage juvenile of Meloidogyne incognita (root-knot nematode) assessed as mortality at 25 degC at 2000 umol/L after 24 hr Rvb = 1.47 to 2.51%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID627878 | Inhibition of histidine-tagged human DNA polymerase gamma using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19
ISSN: 1464-3391 | Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. |
| AID376618 | Inhibition of aromatase in human SKBR3 cells at 100 uM relative to control | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
ISSN: 0163-3864 | Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay. |
| AID483952 | Displacement of 8-anilino-1-naphthalene-sulfonic acid from human FABP4 F16A mutant expressed in Escherichia coli BL21 (DE3) cells at 500 uM after 3 mins | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
ISSN: 1464-3405 | Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. |
| AID1082359 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 0.5% under light conditions measured 24 hr post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID1090873 | Antitermite activity against greater than third-instar stage of Coptotermes formosanus workers/1 soldier in compound-pretreated filter paper assessed as mortality at 0.5% at 26 degC after 6 days (Rvb = 2.5 +/-5%) | 2007 | Journal of agricultural and food chemistry, Dec-26, Volume: 55, Issue:26
ISSN: 0021-8561 | Phytotoxic Eremophilanes from Ligularia macrophylla. |
| AID1110763 | Nematocidal activity against Meloidogyne incognita (root-knot nematode) | 2002 | Annual review of phytopathology, , Volume: 40ISSN: 0066-4286 | Phytochemical based strategies for nematode control. |
| AID323929 | Cytotoxicity against human OR6 cells after 72 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
ISSN: 0066-4804 | Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. |
| AID483948 | Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP3 expressed in Escherichia coli BL21 (DE3) cells after 3 mins relative to linoleic acid | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
ISSN: 1464-3405 | Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. |
| AID402796 | Inhibition of amidolytic activity of human recombinant soluble tissue factor (Ala-TF 1 to 219)/human factor 7a | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11
ISSN: 0163-3864 | Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex. |
| AID1312078 | Displacement of 1,8-ANS from His6-tagged FABP3 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
ISSN: 1464-3391 | The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation. |
| AID1090877 | Antifungal activity against Colletotrichum acutatum assessed as diameter of growth inhibitory zone at 10 ug after 4-5 days by direct bioautography | 2007 | Journal of agricultural and food chemistry, Dec-26, Volume: 55, Issue:26
ISSN: 0021-8561 | Phytotoxic Eremophilanes from Ligularia macrophylla. |
| AID1110759 | Nematocidal activity against Caenorhabditis elegans assessed as mortality | 2002 | Annual review of phytopathology, , Volume: 40ISSN: 0066-4286 | Phytochemical based strategies for nematode control. |
| AID483946 | Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells at 100 uM after 3 mins | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
ISSN: 1464-3405 | Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. |
| AID1083135 | Nematicidal activity against Meloidogyne incognita (root-knot nematode) assessed as cumulative percentage of egg hatching at 25 degC at 2000 umol/L on day 3 (SDW control = 0.57 +/- 0.37%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID423136 | Binding affinity to Vibrio cholerae cholera toxin assessed as inhibition of cholera toxin binding to ganglioside GM1 receptor relative to ganglioside GM1 receptor antagonist m-nitrophenyl-alpha-galactosidase | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
ISSN: 0066-4804 | Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor. |
| AID241990 | Inhibitory activity against rat liver microsomal Acyl coenzyme A:cholesterol acyltransferase | 2004 | Bioorganic & medicinal chemistry letters, Aug-16, Volume: 14, Issue:16
ISSN: 0960-894X | Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas. |
| AID1083124 | Nematicidal activity against second-stage juvenile of Meloidogyne incognita (root-knot nematode) assessed as mortality at 25 degC at 100 umol/L after 24 hr (Rvb = 1.47 to 2.51%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID371576 | Agonist activity at human GPR40 expressed in CHOK1 cells by fluorescence assay | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
ISSN: 1464-3405 | Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists. |
| AID483951 | Displacement of 8-anilino-1-naphthalene-sulfonic acid from human FABP4 F16A mutant expressed in Escherichia coli BL21 (DE3) cells after 3 mins | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
ISSN: 1464-3405 | Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. |
| AID402798 | Inhibition of amidolytic activity of human recombinant soluble tissue factor/human factor 7a preincubated with factor 7a for 90 mins | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11
ISSN: 0163-3864 | Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex. |
| AID1192390 | Inhibition of FABP4 (unknown origin) relative to linoleic acid | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90ISSN: 1768-3254 | Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination. |
| AID642414 | Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
ISSN: 1464-3405 | Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells. |
| AID1090889 | Phytotoxic activity against Lactuca sativa (lettuce) seeds assessed as inhibition of germination at 100 uM at 26 degC measured 7 days post-drug dose | 2007 | Journal of agricultural and food chemistry, Dec-26, Volume: 55, Issue:26
ISSN: 0021-8561 | Phytotoxic Eremophilanes from Ligularia macrophylla. |
| AID402794 | Octanol-water partition coefficient, log P of the compound | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11
ISSN: 0163-3864 | Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex. |
| AID642415 | Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
ISSN: 1464-3405 | Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells. |
| AID323924 | Antiviral activity against HCV assessed as suppression of HCV RNA replication in ORN/C-5B/KE/poly cells after 72 hrs by luciferase reporter assay | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
ISSN: 0066-4804 | Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. |
| AID323930 | Antiviral activity against HCV assessed as inhibition of HCV RNA replication in OR6 cells by luciferase reporter assay | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
ISSN: 0066-4804 | Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. |
| AID1082346 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 5% under light conditions measured 5 to 60 min post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID1082351 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 0.5% under dark conditions measured 24 hr post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID330320 | Inhibition of hepatitis C virus replication in Huh7-K2040 cells in presence of fetal calf serum assessed viral RNA level at 0.1 mM by RT-PCR relative to control | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Nov-20, Volume: 104, Issue:47
ISSN: 1091-6490 | Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E. |
| AID1083132 | Nematicidal activity against Meloidogyne incognita (root-knot nematode) assessed as cumulative percentage of egg hatching at 25 degC at 2000 umol/L on day 7 (SDW control = 12.63 +/- 3.84%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID323932 | Cytotoxicity against human OR6 cells after 120 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
ISSN: 0066-4804 | Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. |
| AID627976 | Cytotoxicity against human HCT116 cells by WST-1 assay | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19
ISSN: 1464-3391 | Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. |
| AID423126 | Binding affinity to Vibrio cholerae cholera toxin assessed as inhibition of cholera toxin binding to ganglioside GM1 receptor treated 15 mins before receptor addition by ELISA | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
ISSN: 0066-4804 | Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor. |
| AID483949 | Selectivity index, ratio of IC50 for His-human FABP3 to IC50 for human His-FABP4 | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
ISSN: 1464-3405 | Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. |
| AID1082344 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 1% under light conditions measured 5 to 60 min post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID627875 | Inhibition of histidine-tagged human DNA polymerase gamma using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19
ISSN: 1464-3391 | Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. |
| AID288712 | Agonist activity at GPR40 in mouse MIN6 cells assessed as stimulation of 25 mM glucose-mediated insulin secretion at 30 uM | 2007 | Journal of medicinal chemistry, Jun-14, Volume: 50, Issue:12
ISSN: 0022-2623 | Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists. |
| AID630398 | Inhibition of GST-tagged human SHP2 N-terminal SH2 domain deficient mutant PTP activity using pNpp as substrate after 30 mins | 2011 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22
ISSN: 1464-3405 | Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2. |
| AID627980 | Cytotoxicity against mouse RAW264.7 cells at 5 uM | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19
ISSN: 1464-3391 | Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. |
| AID455078 | Competitive inhibition of soybean LO1 | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18
ISSN: 1464-3391 | Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1. |
| AID371574 | Agonist activity at human GPR40 expressed in CHOK1 cells assessed as fold increase in calcium flux at 10 uM by fluorescence assay relative to control | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
ISSN: 1464-3405 | Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists. |
| AID1090870 | Antitermite activity against greater than third-instar stage of Coptotermes formosanus workers/1 soldier in compound-pretreated filter paper assessed as filter paper consumption at 0.5% at 26 degC after 21 days (Rvb = 41.4 +/-5.6 mg) | 2007 | Journal of agricultural and food chemistry, Dec-26, Volume: 55, Issue:26
ISSN: 0021-8561 | Phytotoxic Eremophilanes from Ligularia macrophylla. |
| AID402800 | Inhibition of amidolytic activity of human recombinant soluble tissue factor/human factor 7a preincubated with tissue factor for 90 mins | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11
ISSN: 0163-3864 | Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex. |
| AID371575 | Agonist activity at human GPR40 expressed in CHOK1 cells assessed as effect on calcium flux at 10 uM by fluorescence assay | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
ISSN: 1464-3405 | Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists. |
| AID627876 | Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19
ISSN: 1464-3391 | Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. |
| AID483954 | Selectivity ratio of IC50 for human FABP4 F106A mutant to IC50 for human wild type FABP4 | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
ISSN: 1464-3405 | Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. |
| AID658580 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis mc2 155 assessed as modulation of rifampicin-mediated antibacterial activity measuring ratio of rifampicin MIC to rifampicin and compound MIC at 2 mg/L after 72 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
ISSN: 1464-3391 | Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis. |
| AID483947 | Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells after 3 mins | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
ISSN: 1464-3405 | Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. |
| AID627877 | Inhibition of calf DNA polymerase alpha using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19
ISSN: 1464-3391 | Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. |
| AID627981 | Cytotoxicity against mouse RAW264.7 cells | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19
ISSN: 1464-3391 | Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. |
| AID627879 | Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19
ISSN: 1464-3391 | Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. |
| AID658437 | Antibacterial activity against Mycobacterium smegmatis mc2 155 after 72 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
ISSN: 1464-3391 | Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis. |
| AID423133 | Inhibition of intestinal fluid accumulation in rabbit ligated ileal loop model at 3.3 mM injected in presence of cholera toxin after 16 hrs | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
ISSN: 0066-4804 | Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor. |
| AID40631 | Inhibitory activity on germination of Bacillus subtilis PCI219 spores was determined at 2 x 10E-4 M | 1982 | Journal of medicinal chemistry, Mar, Volume: 25, Issue:3
ISSN: 0022-2623 | Quantitative structure-inhibitory activity relationships of phenols and fatty acids for Bacillus subtilis spore germination. |
| AID1192391 | Inhibition of FABP3 (unknown origin) relative to linoleic acid | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90ISSN: 1768-3254 | Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination. |
| AID1624318 | Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay | 2019 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6
ISSN: 1464-3405 | Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine. |
| AID627982 | Antiinflammatory activity in mouse assessed as inhibition of TPA-induced mouse ear edema at 500 ug/ear administered 30 mins before TPA challenge measured after 7 hrs relative to untreated control | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19
ISSN: 1464-3391 | Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. |
| AID1750101 | Induction of GLP-1 secretion in human STC1 cells at 100 uM after 1 hrs by ELISA | 2021 | Journal of medicinal chemistry, 04-08, Volume: 64, Issue:7
ISSN: 1520-4804 | |
| AID323923 | Cytotoxicity against human OR6 cells after 120 hrs by cell viability assay | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
ISSN: 0066-4804 | Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. |
| AID455080 | Allosteric inhibition of soybean LO1 | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18
ISSN: 1464-3391 | Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1. |
| AID1082341 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 0.125% under light conditions measured 5 to 60 min post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID402795 | Inhibition of amidolytic activity of human tissue factor/human factor 7a | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11
ISSN: 0163-3864 | Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex. |
| AID1082342 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 0.25% under light conditions measured 5 to 60 min post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID241603 | Inhibitory activity against human Acyl coenzyme A:cholesterol acyltransferase 2 | 2004 | Bioorganic & medicinal chemistry letters, Aug-16, Volume: 14, Issue:16
ISSN: 0960-894X | Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas. |
| AID627979 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha secretion at 5 uM treated 30 mins before LPS challenge measured after 24 hrs by ELISA | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19
ISSN: 1464-3391 | Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. |
| AID1338209 | Inhibition of Staphylococcus aureus FabI using t-o-NAC-thioester as substrate by spectrophometric method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125ISSN: 1768-3254 | Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives. |
| AID1090894 | Phytotoxic activity against Agrostis stolonifera seeds assessed as inhibition of germination at 10 uM at 26 degC measured 12 days post-drug dose | 2007 | Journal of agricultural and food chemistry, Dec-26, Volume: 55, Issue:26
ISSN: 0021-8561 | Phytotoxic Eremophilanes from Ligularia macrophylla. |
| AID360929 | Selectivity ratio for IC50 for sheep COX2 to IC50 for bovine COX2 | 2001 | Journal of natural products, Jun, Volume: 64, Issue:6
ISSN: 0163-3864 | Cox-2 inhibitory effects of naturally occurring and modified fatty acids. |
| AID423128 | Effect of quaternary structure of Vibrio cholerae cholera toxin by PAGE | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
ISSN: 0066-4804 | Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor. |
| AID380180 | Displacement of [3H]DPCPX from rat adenosine A1 receptor at 0.1 mM by liquid scintillation counting | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
ISSN: 0163-3864 | Interference of linoleic acid fraction in some receptor binding assays. |
| AID630399 | Inhibition of GST-tagged human VHR using pNpp as substrate after 30 mins | 2011 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22
ISSN: 1464-3405 | Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2. |
| AID1616997 | Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity preincubated for 30 mins followed by DNP-HSA stimulation and measured after 30 mins by 4-nitrophenyl 2 | 2019 | Journal of medicinal chemistry, 11-14, Volume: 62, Issue:21
ISSN: 1520-4804 | Structure-Activity Relationships of Fish Oil Derivatives with Antiallergic Activity in Vitro and in Vivo. |
| AID227699 | Virtual screen for compounds with anticonvulsant activity | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16
ISSN: 0960-894X | Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity. |
| AID1090876 | Antifungal activity against Colletotrichum fragariae assessed as growth inhibition at 10 ug after 4-5 days by direct bioautography | 2007 | Journal of agricultural and food chemistry, Dec-26, Volume: 55, Issue:26
ISSN: 0021-8561 | Phytotoxic Eremophilanes from Ligularia macrophylla. |
| AID1083128 | Nematicidal activity against Meloidogyne incognita (root-knot nematode) assessed as cumulative percentage of egg hatching at 25 degC at 100 umol/L on day 21 (SDW control = 44.87 +/- 3.93%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID423137 | Binding affinity to enterotoxigenic Escherichia coli 12566 heat-labile enterotoxin assessed as inhibition of heat-labile enterotoxin binding to ganglioside GM1 receptor | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
ISSN: 0066-4804 | Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor. |
| AID1083125 | Nematicidal activity against second-stage juvenile of Meloidogyne incognita (root-knot nematode) assessed as mortality at 25 degC at 100 umol/L after 12 hr (Rvb = 1.79 to 3.30%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID380183 | Displacement of [3H]DPCPX from rat adenosine A1 receptor at 10 uM by liquid scintillation counting | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
ISSN: 0163-3864 | Interference of linoleic acid fraction in some receptor binding assays. |
| AID1083136 | Nematicidal activity against Meloidogyne incognita (root-knot nematode) assessed as cumulative percentage of egg hatching at 25 degC at 1000 umol/L on day 3 (SDW control = 0.57 +/- 0.37%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID1090872 | Antitermite activity against greater than third-instar stage of Coptotermes formosanus workers/1 soldier in compound-pretreated filter paper assessed as mortality at 0.5% at 26 degC after 13 days (Rvb = 3.8 +/-4.8%) | 2007 | Journal of agricultural and food chemistry, Dec-26, Volume: 55, Issue:26
ISSN: 0021-8561 | Phytotoxic Eremophilanes from Ligularia macrophylla. |
| AID402799 | Inhibition of amidolytic activity of human recombinant soluble tissue factor/human factor 7a preincubated with tissue factor for 15 mins | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11
ISSN: 0163-3864 | Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex. |
| AID1083134 | Nematicidal activity against Meloidogyne incognita (root-knot nematode) assessed as cumulative percentage of egg hatching at 25 degC at 100 umol/L on day 7 (SDW control = 12.63 +/- 3.84%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID1090891 | Phytotoxic activity against Agrostis stolonifera seeds assessed as inhibition of germination at 1 uM at 26 degC measured 12 days post-drug dose | 2007 | Journal of agricultural and food chemistry, Dec-26, Volume: 55, Issue:26
ISSN: 0021-8561 | Phytotoxic Eremophilanes from Ligularia macrophylla. |
| AID1083130 | Nematicidal activity against Meloidogyne incognita (root-knot nematode) assessed as cumulative percentage of egg hatching at 25 degC at 1000 umol/L on day 14 (SDW control = 35.77 +/- 4.48%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID1090887 | Phytotoxic activity against Lactuca sativa (lettuce) seeds assessed as inhibition of germination at 1 uM at 26 degC measured 7 days post-drug dose | 2007 | Journal of agricultural and food chemistry, Dec-26, Volume: 55, Issue:26
ISSN: 0021-8561 | Phytotoxic Eremophilanes from Ligularia macrophylla. |
| AID1083122 | Nematicidal activity against second-stage juvenile of Meloidogyne incognita (root-knot nematode) assessed as mortality at 25 degC at 1000 umol/L after 24 hr Rvb = 1.47 to 2.51%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID1076682 | Antinociceptive activity in CD-1 mouse assessed as inhibition of acetic acid-induced writhing at 10 mg/kg, sc administered 15 mins before acetic acid challenge measured after 20 mins | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75ISSN: 1768-3254 | Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel. |
| AID492140 | Antioxidant activity assessed as formazan formation induced absorbance changes at 25 ppm at 570 nm at 37 degC for 6 hrs by MTT assay | 2010 | Journal of natural products, Jul-23, Volume: 73, Issue:7
ISSN: 1520-6025 | An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds. |
| AID380179 | Displacement of [3H]nitrobenzylthiosine from nucleoside transport protein in calf lung membrane at 1 mM | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
ISSN: 0163-3864 | Interference of linoleic acid fraction in some receptor binding assays. |
| AID380181 | Displacement of [3H]naloxone from rat opioid receptor at 0.1 mM | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
ISSN: 0163-3864 | Interference of linoleic acid fraction in some receptor binding assays. |
| AID1082337 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 0.5% under dark conditions measured 5 to 60 min post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID323931 | Antiviral activity against HCV assessed as inhibition of HCV RNA replication in OR6 cells at 50 uM after 120 hrs by luciferase reporter assay | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
ISSN: 0066-4804 | Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. |
| AID380186 | Displacement of [3H]DPCPX from rat brain adenosine A1 receptor at 56 uM assessed per mg of protein by saturation analysis | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
ISSN: 0163-3864 | Interference of linoleic acid fraction in some receptor binding assays. |
| AID402793 | Inhibition of pig pancreatic trypsin after 15 mins | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11
ISSN: 0163-3864 | Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex. |
| AID1674108 | Inhibition of human AKR1C3 expressed in Escherichia coli BL21(DE3) pLysS cells using S-tetralol as substrate | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
ISSN: 1520-4804 | Overview of AKR1C3: Inhibitor Achievements and Disease Insights. |
| AID1624319 | Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay relative to linoleic acid | 2019 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6
ISSN: 1464-3405 | Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine. |
| AID288713 | Agonist activity at GPR40 in mouse MIN6 cells assessed as stimulation of 5 mM glucose-mediated insulin secretion at 30 uM | 2007 | Journal of medicinal chemistry, Jun-14, Volume: 50, Issue:12
ISSN: 0022-2623 | Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists. |
| AID380185 | Displacement of [3H]nitrobenzylthiosine from nucleoside transport protein in calf lung membrane at 10 uM | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
ISSN: 0163-3864 | Interference of linoleic acid fraction in some receptor binding assays. |
| AID371573 | Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
ISSN: 1464-3405 | Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists. |
| AID145834 | Effect on Torpedo nicotinic ACh receptor responses at 0 min determined by measuring percentage of original amplitude | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
ISSN: 0960-894X | The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. |
| AID1083126 | Nematicidal activity against Meloidogyne incognita (root-knot nematode) assessed as cumulative percentage of egg hatching at 25 degC at 2000 umol/L on day 21 (SDW control = 44.87 +/- 3.93%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID423130 | Binding affinity to Vibrio cholerae cholera toxin assessed as decrease in fluorescence intensity by fluorescence emission spectroscopy | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
ISSN: 0066-4804 | Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor. |
| AID1082339 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 2% under dark conditions measured 5 to 60 min post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID483950 | Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells after 3 mins relative to linoleic acid | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
ISSN: 1464-3405 | Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. |
| AID1090875 | Antifungal activity against Colletotrichum gloeosporioides assessed as growth inhibition at 10 ug after 4-5 days by direct bioautography | 2007 | Journal of agricultural and food chemistry, Dec-26, Volume: 55, Issue:26
ISSN: 0021-8561 | Phytotoxic Eremophilanes from Ligularia macrophylla. |
| AID628060 | Inhibition of recombinant His-tagged human DNA polymerase lambda using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19
ISSN: 1464-3391 | Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. |
| AID1509163 | Displacement of 3[H]retinol from human biotinylated RBP4 after overnight incubation by surface plasmon resonance analysis | 2019 | Journal of medicinal chemistry, 06-13, Volume: 62, Issue:11
ISSN: 1520-4804 | Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis. |
| AID402797 | Inhibition of amidolytic activity of human recombinant soluble tissue factor/human factor 7a preincubated with factor 7a for 15 mins | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11
ISSN: 0163-3864 | Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex. |
| AID1083121 | Nematicidal activity against second-stage juvenile of Meloidogyne incognita (root-knot nematode) assessed as mortality at 25 degC at 2000 umol/L after 12 hr (Rvb = 1.79 to 3.30%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID424805 | Agonist activity at human PPARgamma ligand binding domain expressed in MEF cells co-transfected with Gal4-responsive luciferase vector assessed as photinus/renilla luciferase activity at 40 uM by transactivation assay relative to control | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5
ISSN: 1520-6025 | Activation of PPARgamma by metabolites from the flowers of purple coneflower (Echinacea purpurea). |
| AID376617 | Inhibition of aromatase in human placental microsomes by radiometric method | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
ISSN: 0163-3864 | Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay. |
| AID1083127 | Nematicidal activity against Meloidogyne incognita (root-knot nematode) assessed as cumulative percentage of egg hatching at 25 degC at 1000 umol/L on day 21 (SDW control = 44.87 +/- 3.93%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID360927 | Inhibition of sheep COX2-mediated prostaglandin biosynthesis using [1-14C]arachidonic acid | 2001 | Journal of natural products, Jun, Volume: 64, Issue:6
ISSN: 0163-3864 | Cox-2 inhibitory effects of naturally occurring and modified fatty acids. |
| AID1083137 | Nematicidal activity against Meloidogyne incognita (root-knot nematode) root-knot nematodes assessed as cumulative percentage of egg hatching at 25 degC at 100 umol/L on day 3 (SDW control = 0.57 +/- 0.37%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID409935 | Activity of soybean lipoxygenase 1 | 2008 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
ISSN: 1464-3405 | Kinetic isotope effects in the oxidation of arachidonic acid by soybean lipoxygenase-1. |
| AID380178 | Displacement of [3H]naloxone from rat opioid receptor at 1 mM | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
ISSN: 0163-3864 | Interference of linoleic acid fraction in some receptor binding assays. |
| AID1083131 | Nematicidal activity against Meloidogyne incognita (root-knot nematode) assessed as cumulative percentage of egg hatching at 25 degC at 100 umol/L on day 14 (SDW control = 35.77 +/- 4.48%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID1082349 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 0.125% under dark conditions measured 24 hr post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID403341 | Inhibition of COX1 | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7
ISSN: 0163-3864 | Expanding the ChemGPS chemical space with natural products. |
| AID1083133 | Nematicidal activity against Meloidogyne incognita (root-knot nematode) assessed as cumulative percentage of egg hatching at 25 degC at 1000 umol/L on day 7 (SDW control = 12.63 +/- 3.84%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID1178768 | Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14
ISSN: 1464-3405 | Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). |
| AID1082350 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 0.25% under dark conditions measured 24 hr post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID423127 | Blockade of anti-CT antibody binding site of Vibrio cholerae cholera toxin preincubated for 15 mins before addition of anti-CT immunoglobulin G by immunoprecipitation-based SDS-PAGE | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
ISSN: 0066-4804 | Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor. |
| AID1082357 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 0.125% under light conditions measured 24 hr post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID1090871 | Antitermite activity against greater than third-instar stage of Coptotermes formosanus workers/1 soldier in compound-pretreated filter paper assessed as mortality at 0.5% at 26 degC after 21 days (Rvb = 3.8 +/-4.8%) | 2007 | Journal of agricultural and food chemistry, Dec-26, Volume: 55, Issue:26
ISSN: 0021-8561 | Phytotoxic Eremophilanes from Ligularia macrophylla. |
| AID423129 | Binding affinity to Vibrio cholerae cholera toxin assessed as apparent isoelectric point at 100 mM by isoelectric focusing analysis (isoelectric point Rvb=6.8) | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
ISSN: 0066-4804 | Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor. |
| AID455079 | Mixed-type inhibition of soybean LO1 | 2009 | Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18
ISSN: 1464-3391 | Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1. |
| AID1090874 | Antitermite activity against greater than third-instar stage of Coptotermes formosanus workers/1 soldier in compound-pretreated filter paper assessed as mortality at 0.5% at 26 degC after 1 day (Rvb = 0%) | 2007 | Journal of agricultural and food chemistry, Dec-26, Volume: 55, Issue:26
ISSN: 0021-8561 | Phytotoxic Eremophilanes from Ligularia macrophylla. |
| AID1178769 | Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as maximal calcium mobilization after 24 hrs by FLIPR relative to GSK137647A | 2014 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14
ISSN: 1464-3405 | Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). |
| AID1885200 | Binding affinity towards Nurr1 ligand binding domain (unknown origin) measured by tryptophan fluorescence spectroscopy | 2022 | Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
ISSN: 1520-4804 | Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration. |
| AID1090888 | Phytotoxic activity against Lactuca sativa (lettuce) seeds assessed as inhibition of germination at 1000 uM at 26 degC measured 7 days post-drug dose | 2007 | Journal of agricultural and food chemistry, Dec-26, Volume: 55, Issue:26
ISSN: 0021-8561 | Phytotoxic Eremophilanes from Ligularia macrophylla. |
| AID145835 | Effect on Torpedo nicotinic ACh receptor responses at 10 min determined by measuring percentage of original amplitude | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
ISSN: 0960-894X | The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. |
| AID1082335 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 0.125% under dark conditions measured 5 to 60 min post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID1192388 | Inhibition of FABP4 (unknown origin) at 100 uM | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90ISSN: 1768-3254 | Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination. |
| AID1082338 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 1% under dark conditions measured 5 to 60 min post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID1090890 | Phytotoxic activity against Lactuca sativa (lettuce) seeds assessed as inhibition of germination at 10 uM at 26 degC measured 7 days post-drug dose | 2007 | Journal of agricultural and food chemistry, Dec-26, Volume: 55, Issue:26
ISSN: 0021-8561 | Phytotoxic Eremophilanes from Ligularia macrophylla. |
| AID1082358 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 0.25% under light conditions measured 24 hr post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID1082343 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 0.5% under light conditions measured 5 to 60 min post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID1312065 | Displacement of 1,8-ANS from His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
ISSN: 1464-3391 | The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation. |
| AID1082352 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 1% under dark conditions measured 24 hr post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID658578 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis mc2 155 assessed as modulation of EtBr-mediated antibacterial activity measuring ratio of EtBr MIC to EtBr and compound MIC at 2 mg/L after 72 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
ISSN: 1464-3391 | Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis. |
| AID323925 | Antiviral activity against HCV assessed as suppression of HCV RNA replication in ORN/3-5B/KE/poly cells after 72 hrs by luciferase reporter assay | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
ISSN: 0066-4804 | Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. |
| AID1674107 | Inhibition of human AKR1C3 expressed in Escherichia coli BL21(DE3) pLysS cells using 9,10-phenanthrenequinone as substrate | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
ISSN: 1520-4804 | Overview of AKR1C3: Inhibitor Achievements and Disease Insights. |
| AID1082345 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 2% under light conditions measured 5 to 60 min post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID1090893 | Phytotoxic activity against Agrostis stolonifera seeds assessed as inhibition of germination at 100 uM at 26 degC measured 12 days post-drug dose | 2007 | Journal of agricultural and food chemistry, Dec-26, Volume: 55, Issue:26
ISSN: 0021-8561 | Phytotoxic Eremophilanes from Ligularia macrophylla. |
| AID483953 | Displacement of 8-anilino-1-naphthalene-sulfonic acid from human FABP4 F16A mutant expressed in Escherichia coli BL21 (DE3) cells at 700 uM after 3 mins | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
ISSN: 1464-3405 | Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. |
| AID630402 | Inhibition of GST-tagged human HePTP using pNpp as substrate after 30 mins | 2011 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22
ISSN: 1464-3405 | Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2. |
| AID1083129 | Nematicidal activity against Meloidogyne incognita (root-knot nematode) assessed as cumulative percentage of egg hatching at 25 degC at 2000 umol/L on day 14 (SDW control = 35.77 +/- 4.48%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID1192392 | Selectivity ratio of IC50 for FABP3 (unknown origin) to IC50 for FABP4 (unknown origin) | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90ISSN: 1768-3254 | Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination. |
| AID627880 | Inhibition of recombinant His-tagged human DNA polymerase lambda using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19
ISSN: 1464-3391 | Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. |
| AID3081 | Ratio of proximal to distal region oxidation by 1-lipoxygenase isolated from soybean; Ratio of proximal and distal was 97:3 | 1999 | Bioorganic & medicinal chemistry letters, Jan-04, Volume: 9, Issue:1
ISSN: 0960-894X | New minimal substrate structural requirements in the enzymatic peroxidation of alkenes with soybean lipoxygenase. |
| AID241602 | Inhibitory activity against human Acyl coenzyme A:cholesterol acyltransferase 1 | 2004 | Bioorganic & medicinal chemistry letters, Aug-16, Volume: 14, Issue:16
ISSN: 0960-894X | Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas. |
| AID627874 | Inhibition of calf DNA polymerase alpha using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | 2011 | Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19
ISSN: 1464-3391 | Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. |
| AID1418782 | Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assay | 2018 | Bioorganic & medicinal chemistry, 12-01, Volume: 26, Issue:22
ISSN: 1464-3391 | Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles. |
| AID323922 | Antiviral activity against HCV assessed as inhibition of HCV RNA replication in OR6 cells after 72 hrs by luciferase reporter assay | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
ISSN: 0066-4804 | Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. |
| AID1312066 | Binding affinity to His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells assessed as change in melting temperature at 50 uM after 30 mins by SYPRO orange dye based thermal stability shift assay | 2016 | Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
ISSN: 1464-3391 | The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation. |
| AID380182 | Displacement of [3H]nitrobenzylthiosine from nucleoside transport protein in calf lung membrane at 0.1 mM | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
ISSN: 0163-3864 | Interference of linoleic acid fraction in some receptor binding assays. |
| AID1083123 | Nematicidal activity against second-stage juvenile of Meloidogyne incognita (root-knot nematode) assessed as mortality at 25 degC at 1000 umol/L after 12 hr (Rvb = 1.79 to 3.30%) | 2012 | Journal of agricultural and food chemistry, Nov-21, Volume: 60, Issue:46
ISSN: 1520-5118 | Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita. |
| AID380176 | Displacement of [3H]DPCPX from rat adenosine A1 receptor by liquid scintillation counting | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
ISSN: 0163-3864 | Interference of linoleic acid fraction in some receptor binding assays. |
| AID1229245 | Induction of somatostatin (ss-14) secretion in human pancreatic islets at 100 uM incubated for 60 mins in presence of 2 mM and 16 mM glucose | 2015 | ACS medicinal chemistry letters, May-14, Volume: 6, Issue:5
ISSN: 1948-5875 | Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes. |
| AID483955 | Selectivity ratio of IC50 for human FABP4 F126A mutant to IC50 for human wild type FABP4 | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
ISSN: 1464-3405 | Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. |
| AID1058850 | Critical micelle concentration of the compound in 0.1 M sodiumborate buffer at pH 10 at 23 degC | 2013 | Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24
ISSN: 1464-3391 | Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection. |
| AID1082336 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 0.25% under dark conditions measured 5 to 60 min post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID376615 | Inhibition of aromatase in human placental microsomes at 20 ug/ml by radiometric method relative to control | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
ISSN: 0163-3864 | Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay. |
| AID371570 | Agonist activity at GPR40 | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
ISSN: 1464-3405 | Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists. |
| AID1082360 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 1% under light conditions measured 24 hr post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID1082340 | Nematicidal activity against Heterodera zeae infective stage larvae assessed as nematode mortality at 5% under dark conditions measured 5 to 60 min post dose by stereoscopic microscopy | 2011 | Journal of agricultural and food chemistry, Sep-14, Volume: 59, Issue:17
ISSN: 1520-5118 | Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. |
| AID1192389 | Inhibition of FABP4 (unknown origin) | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90ISSN: 1768-3254 | Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination. |
| AID380184 | Displacement of [3H]naloxone from rat opioid receptor at 10 uM | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
ISSN: 0163-3864 | Interference of linoleic acid fraction in some receptor binding assays. |
| AID380177 | Displacement of [3H]DPCPX from rat adenosine A1 receptor at 1 mM by liquid scintillation counting | 1999 | Journal of natural products, Jun, Volume: 62, Issue:6
ISSN: 0163-3864 | Interference of linoleic acid fraction in some receptor binding assays. |
| AID360928 | Inhibition of bovine COX1-mediated prostaglandin biosynthesis using [1-14C]arachidonic acid | 2001 | Journal of natural products, Jun, Volume: 64, Issue:6
ISSN: 0163-3864 | Cox-2 inhibitory effects of naturally occurring and modified fatty acids. |
| AID658579 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis mc2 155 assessed as modulation of isoniazid-mediated antibacterial activity measuring ratio of isoniazid MIC to isoniazid and compound MIC at 2 mg/L after 72 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
ISSN: 1464-3391 | Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
ISSN: 2211-1247 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1802832 | Ligand Binding Assay from Article 10.1074/jbc.M113.514646: \\Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor u00DF/d (FABP5-PPARu00DF/d) signaling pathway.\\ | 2014 | The Journal of biological chemistry, May-23, Volume: 289, Issue:21
ISSN: 1083-351X | Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway. |
Research
Studies (6,609)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 1139 (17.23) | 18.7374 |
| 1990's | 1398 (21.15) | 18.2507 |
| 2000's | 1890 (28.60) | 29.6817 |
| 2010's | 1595 (24.13) | 24.3611 |
| 2020's | 587 (8.88) | 2.80 |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 314 (4.57%) | 5.53% |
| Reviews | 335 (4.87%) | 6.00% |
| Case Studies | 23 (0.33%) | 4.05% |
| Observational | 11 (0.16%) | 0.25% |
| Other | 6,195 (90.07%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| 2,3-dihydroxybenzoic acid | | dihydroxybenzoic acid | human xenobiotic metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tartronic acid | | dicarboxylic acid;
dicarboxylic fatty acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| protocatechuic acid | | catechols;
dihydroxybenzoic acid | antineoplastic agent;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor;
human xenobiotic metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3-phenylpropionic acid | | benzenes;
monocarboxylic acid | antifungal agent;
human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-hydroxybenzyl alcohol | | benzyl alcohols;
phenols | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-hydroxybenzaldehyde | | hydroxybenzaldehyde | EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-hydroxyphenylacetic acid | | monocarboxylic acid;
phenols | fungal metabolite;
human metabolite;
mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-hydroxybenzoic acid | | monohydroxybenzoic acid | algal metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| aminolevulinic acid | | 4-oxo monocarboxylic acid;
amino acid zwitterion;
delta-amino acid | antineoplastic agent;
dermatologic drug;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite;
prodrug;
Saccharomyces cerevisiae metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| allantoic acid | | ureas | mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| benzaldehyde | | benzaldehydes | EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
EC 3.5.5.1 (nitrilase) inhibitor;
flavouring agent;
fragrance;
odorant receptor agonist;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| benzoic acid | | benzoic acids | algal metabolite;
antimicrobial food preservative;
drug allergen;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
human xenobiotic metabolite;
plant metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| betaine aldehyde | | quaternary ammonium ion | Aspergillus metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cadaverine | | alkane-alpha,omega-diamine | Daphnia magna metabolite;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| catechol | | catechols | allelochemical;
genotoxin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| choline | | cholines | allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1963 | 2020 | 33.8 | low | 0 | 6 | 1 | 0 | 3 | 0 |
| coumarin | | coumarins | fluorescent dye;
human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cuminol | | benzyl alcohols;
p-menthane monoterpenoid | fragrance;
insect repellent;
plant metabolite;
volatile oil component;
xenobiotic metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cuminaldehyde | | benzaldehydes | insecticide;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-vinylguaiacol | | phenols | flavouring agent;
pheromone;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| salicylic acid | | monohydroxybenzoic acid | algal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite | 1982 | 2022 | 15.6 | low | 1 | 1 | 1 | 3 | 3 | 1 |
| 4-methylumbelliferyl acetate | | acetate ester;
coumarins | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gallic acid | | trihydroxybenzoic acid | antineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite | 2002 | 2020 | 13.2 | low | 0 | 0 | 0 | 6 | 8 | 0 |
| indoleacetamide | | indoles;
monocarboxylic acid amide;
N-acylammonia | bacterial metabolite;
fungal metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| caprylic aldehyde | | medium-chain fatty aldehyde;
n-alkanal;
saturated fatty aldehyde | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n(1)-methylnicotinamide | | pyridinium ion | algal metabolite;
anti-inflammatory agent;
human urinary metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| guaiacol | | guaiacols | disinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 1-aminocyclopropane-1-carboxylic acid | | amino acid zwitterion;
monocarboxylic acid;
non-proteinogenic alpha-amino acid | ethylene releasers;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3,4-dihydrocoumarin | | chromanone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| homogentisic acid | | dihydroxyphenylacetic acid;
hydroquinones | human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| indoleacetic acid | | indole-3-acetic acids;
monocarboxylic acid | auxin;
human metabolite;
mouse metabolite;
plant hormone;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| indol-3-yl pyruvic acid | | 2-oxo monocarboxylic acid;
indol-3-yl carboxylic acid | plant metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| melilotic acid | | monocarboxylic acid;
phenols | bacterial xenobiotic metabolite;
fungal xenobiotic metabolite;
human xenobiotic metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| racemethionine | | alpha-amino acid;
amino acid zwitterion;
sulfur-containing amino acid | algal metabolite;
Daphnia magna metabolite;
Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-methylphenylethanolamine | | alkaloid;
phenylethanolamines | human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| naphthalene | | naphthalenes;
ortho-fused bicyclic arene | apoptosis inhibitor;
carcinogenic agent;
environmental contaminant;
mouse metabolite;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| niacin | | pyridine alkaloid;
pyridinemonocarboxylic acid;
vitamin B3 | antidote;
antilipemic drug;
EC 3.5.1.19 (nicotinamidase) inhibitor;
Escherichia coli metabolite;
human urinary metabolite;
metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent | 1963 | 2014 | 34.8 | low | 0 | 4 | 3 | 1 | 2 | 0 |
| 1-octanol | | octanol;
primary alcohol | antifungal agent;
bacterial metabolite;
fuel additive;
kairomone;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| oxalic acid | | alpha,omega-dicarboxylic acid | algal metabolite;
human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-aminobenzoic acid | | aminobenzoic acid;
aromatic amino-acid zwitterion | allergen;
Escherichia coli metabolite;
plant metabolite | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| palmitic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor;
plant metabolite | 1962 | 2023 | 27.7 | low | 14 | 140 | 121 | 108 | 120 | 15 |
| phenylacetic acid | | benzenes;
monocarboxylic acid;
phenylacetic acids | allergen;
Aspergillus metabolite;
auxin;
EC 6.4.1.1 (pyruvate carboxylase) inhibitor;
Escherichia coli metabolite;
human metabolite;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite;
toxin | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| prephenic acid | | oxo dicarboxylic acid | Escherichia coli metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pyridoxamine | | aminoalkylpyridine;
hydroxymethylpyridine;
monohydroxypyridine;
vitamin B6 | Escherichia coli metabolite;
human metabolite;
iron chelator;
mouse metabolite;
nephroprotective agent;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pyrogallol | | benzenetriol;
phenolic donor | plant metabolite | 1994 | 2001 | 26.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| tryptamine | | aminoalkylindole;
aralkylamino compound;
indole alkaloid;
tryptamines | human metabolite;
mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| vanillin | | benzaldehydes;
monomethoxybenzene;
phenols | anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aminopropionitrile | | aminopropionitrile | antineoplastic agent;
antirheumatic drug;
collagen cross-linking inhibitor;
plant metabolite | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| meglutol | | 3-hydroxy carboxylic acid;
dicarboxylic acid;
tertiary alcohol | anticholesteremic drug;
antimetabolite;
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor;
human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methylbufotenin | | aromatic ether;
tertiary amino compound;
tryptamine alkaloid | hallucinogen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 7,8-dihydroxyflavone | | dihydroxyflavone | antidepressant;
antineoplastic agent;
antioxidant;
plant metabolite;
tropomyosin-related kinase B receptor agonist | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| anabasine | | piperidine alkaloid;
pyridine alkaloid | nicotinic acetylcholine receptor agonist;
plant metabolite;
teratogenic agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| acetovanillone | | acetophenones;
aromatic ketone;
methyl ketone | antirheumatic drug;
EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| azelaic acid | | alpha,omega-dicarboxylic acid;
dicarboxylic fatty acid | antibacterial agent;
antineoplastic agent;
dermatologic drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| benzyl benzoate | | benzoate ester;
benzyl ester | acaricide;
plant metabolite;
scabicide | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5-methoxypsoralen | | 5-methoxyfurocoumarin;
organic heterotricyclic compound;
psoralens | hepatoprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one | | aromatic ether;
benzoxazine;
cyclic hydroxamic acid;
lactol | allelochemical;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| caffeic acid | | catechols;
hydroxycinnamic acid | antioxidant;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| caffeine | | purine alkaloid;
trimethylxanthine | adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic | 1994 | 2008 | 21.0 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| beta-glycerophosphoric acid | | glycerol monophosphate | Escherichia coli metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| camphor, (+-)-isomer | | bornane monoterpenoid;
cyclic monoterpene ketone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cetyl alcohol | | hexadecanol;
long-chain primary fatty alcohol | algal metabolite;
flavouring agent;
human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| chrysanthemic acid | | cyclopropanes;
monocarboxylic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| colchicine, (+-)-isomer | | acetamides;
alkaloid;
aromatic ether;
carbotricyclic compound | microtubule-destabilising agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| danthron | | dihydroxyanthraquinone | apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| decanoic acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
anti-inflammatory agent;
antibacterial agent;
human metabolite;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| benzophenone | | benzophenones | photosensitizing agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ellipticine | | indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| embelin | | dihydroxy-1,4-benzoquinones | antimicrobial agent;
antineoplastic agent;
hepatitis C protease inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| emodin | | trihydroxyanthraquinone | antineoplastic agent;
laxative;
plant metabolite;
tyrosine kinase inhibitor | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| guvacine | | alpha,beta-unsaturated monocarboxylic acid;
beta-amino acid;
pyridine alkaloid;
secondary amino compound;
tetrahydropyridine | GABA reuptake inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| beta-thujaplicin | | cyclic ketone;
enol;
monoterpenoid | antibacterial agent;
antifungal agent;
antineoplastic agent;
antiplasmodial drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| indole-3-carbinol | | indolyl alcohol | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| indolepropionic acid | | indol-3-yl carboxylic acid | auxin;
human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| beta-lapachone | | benzochromenone;
orthoquinones | anti-inflammatory agent;
antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| lauric acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
antibacterial agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methoxsalen | | aromatic ether;
psoralens | antineoplastic agent;
cross-linking reagent;
dermatologic drug;
photosensitizing agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| masoprocol | | catechols;
lignan;
tetrol | antioxidant;
ferroptosis inhibitor;
geroprotector;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| phloretin | | dihydrochalcones | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-aminobenzoic acid | | aminobenzoate;
aromatic amino-acid anion | Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| protopine | | dibenzazecine alkaloid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| safrole | | benzodioxoles | flavouring agent;
insecticide;
metabolite;
plant metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sebacic acid | | alpha,omega-dicarboxylic acid;
dicarboxylic fatty acid | human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| stearic acid | | long-chain fatty acid;
saturated fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sulforaphane | | isothiocyanate;
sulfoxide | antineoplastic agent;
antioxidant;
EC 3.5.1.98 (histone deacetylase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| theobromine | | dimethylxanthine | adenosine receptor antagonist;
bronchodilator agent;
food component;
human blood serum metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| triacetin | | triglyceride | adjuvant;
antifungal drug;
food additive carrier;
food emulsifier;
food humectant;
fuel additive;
plant metabolite;
solvent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| trigonelline | | alkaloid;
iminium betaine | food component;
human urinary metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| undecylenic acid | | undecenoic acid | antifungal drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| reserpine | | alkaloid ester;
methyl ester;
yohimban alkaloid | adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| hydroxyproline | | 4-hydroxyproline;
L-alpha-amino acid zwitterion | human metabolite;
mouse metabolite;
plant metabolite | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| dipropylenetriame | | polyazaalkane | algal metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| lysine | | aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid | algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1964 | 2023 | 23.6 | low | 0 | 3 | 3 | 5 | 1 | 2 |
| vincristine | | acetate ester;
formamides;
methyl ester;
organic heteropentacyclic compound;
organic heterotetracyclic compound;
tertiary alcohol;
tertiary amino compound;
vinca alkaloid | antineoplastic agent;
drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| levodopa | | amino acid zwitterion;
dopa;
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid | allelochemical;
antidyskinesia agent;
antiparkinson drug;
dopaminergic agent;
hapten;
human metabolite;
mouse metabolite;
neurotoxin;
plant growth retardant;
plant metabolite;
prodrug | 1994 | 2018 | 18.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| phenylethyl alcohol | | benzenes;
primary alcohol | Aspergillus metabolite;
fragrance;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1993 | 2016 | 14.9 | low | 0 | 0 | 1 | 2 | 4 | 0 |
| phlorhizin | | aryl beta-D-glucoside;
dihydrochalcones;
monosaccharide derivative | antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| leucine | | amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1987 | 2012 | 22.5 | low | 0 | 2 | 2 | 5 | 2 | 0 |
| phenylalanine | | amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid | algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1992 | 2023 | 14.4 | low | 3 | 0 | 3 | 4 | 4 | 3 |
| ficusin | | psoralens | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| asparagine | | amino acid zwitterion;
asparagine;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-pentanol | | pentanol;
short-chain primary fatty alcohol | human metabolite;
plant metabolite | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| threonine | | amino acid zwitterion;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
threonine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1964 | 2022 | 17.5 | low | 0 | 1 | 0 | 0 | 1 | 2 |
| alizarin | | dihydroxyanthraquinone | chromophore;
dye;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tryptophan | | erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan | antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1990 | 2023 | 16.9 | low | 0 | 0 | 7 | 3 | 4 | 3 |
| isoleucine | | aspartate family amino acid;
isoleucine;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1964 | 2022 | 17.0 | low | 0 | 1 | 0 | 1 | 3 | 1 |
| ethane | | alkane;
gas molecular entity | plant metabolite;
refrigerant | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| gibberellic acid | | C19-gibberellin;
gibberellin monocarboxylic acid;
lactone;
organic heteropentacyclic compound | mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isophorone | | cyclic ketone;
enone | plant metabolite;
solvent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| linalool | | monoterpenoid;
tertiary alcohol | antimicrobial agent;
fragrance;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isoprene | | alkadiene;
hemiterpene;
volatile organic compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isobutylamine | | alkylamines | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isobutyric acid | | branched-chain saturated fatty acid;
fatty acid 4:0;
methyl-branched fatty acid | Daphnia magna metabolite;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| camphene | | carbobicyclic compound;
monoterpene | fragrance;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| alpha-pinene | | pinene | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| purpurin | | trihydroxyanthraquinone | biological pigment;
histological dye;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| visnagin | | aromatic ether;
furanochromone;
polyketide | anti-inflammatory agent;
antihypertensive agent;
EC 1.1.1.37 (malate dehydrogenase) inhibitor;
phytotoxin;
plant metabolite;
vasodilator agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2,6-dihydroxyanthraquinone | | dihydroxyanthraquinone | antimutagen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methyl n-methylanthranilate | | benzoate ester;
methyl ester;
secondary amino compound;
substituted aniline | animal metabolite;
fungal metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gramine | | aminoalkylindole;
indole alkaloid;
tertiary amino compound | antibacterial agent;
antiviral agent;
plant metabolite;
serotonergic antagonist | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-furoic acid | | furoic acid | bacterial xenobiotic metabolite;
human xenobiotic metabolite;
inhibitor;
plant metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| piperitone | | cyclic terpene ketone;
p-menthane monoterpenoid | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| resacetophenone | | dihydroxyacetophenone;
resorcinols | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| salicylaldehyde | | hydroxybenzaldehyde | nematicide;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1-methylnaphthalene | | methylnaphthalene | carcinogenic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pseudoephedrine | | phenylethanolamines;
secondary alcohol;
secondary amino compound | anti-asthmatic drug;
bronchodilator agent;
central nervous system drug;
nasal decongestant;
plant metabolite;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pyrogallol 1,3-dimethyl ether | | dimethoxybenzene;
phenols | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| veratrole | | dimethoxybenzene | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isatin | | indoledione | EC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| phenothiazine | | phenothiazine | ferroptosis inhibitor;
plant metabolite;
radical scavenger | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| veratric acid | | benzoic acids | allergen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| synephrine | | ethanolamines;
phenethylamine alkaloid;
phenols | alpha-adrenergic agonist;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| piperonylic acid | | aromatic carboxylic acid;
benzodioxoles;
monocarboxylic acid | antifungal agent;
EC 1.14.14.91 ( trans-cinnamate 4-monooxygenase) inhibitor;
plant metabolite;
vulnerary | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| benzothiazole | | benzothiazoles | environmental contaminant;
plant metabolite;
xenobiotic | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-methylbutanal | | 2-methyl-branched fatty aldehyde;
methylbutanal | plant metabolite;
Saccharomyces cerevisiae metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methylcyclopentane | | cycloalkane;
volatile organic compound | human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| phosphoribosyl pyrophosphate | | 5-O-phosphono-D-ribofuranosyl diphosphate | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-methylvaleric acid | | branched-chain saturated fatty acid;
methyl-branched fatty acid;
monocarboxylic acid;
short-chain fatty acid | flavouring agent;
fragrance;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ethyl 2-methylpropanoate | | fatty acid ethyl ester | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3-hydroxybenzoic acid | | monohydroxybenzoic acid | bacterial metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methyl gallate | | gallate ester | anti-inflammatory agent;
antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| carveol | | limonene monoterpenoid | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methylparaben | | paraben | antifungal agent;
antimicrobial food preservative;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| alpha phellandrene | | cyclohexadiene;
phellandrene | antimicrobial agent;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gamma-terpinene | | cyclohexadiene;
monoterpene | antioxidant;
human xenobiotic metabolite;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| alpha-terpinene | | cyclohexadiene;
monoterpene | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-cymene | | monoterpene;
toluenes | human urinary metabolite;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-hydroxyacetophenone | | monohydroxyacetophenone | fungal metabolite;
mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-anisic acid | | methoxybenzoic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| styrene | | styrenes;
vinylarene;
volatile organic compound | mouse metabolite;
mutagen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| benzylamine | | aralkylamine;
primary amine | allergen;
EC 3.5.5.1 (nitrilase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| anisole | | monomethoxybenzene | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| phenyl ether | | aromatic ether | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1,3-diphenylurea | | phenylureas | cytokinin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3-phenylpropanal | | aldehyde;
benzenes | flavouring agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-ethylhexanol | | primary alcohol | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-methylbenzaldehyde | | tolualdehyde | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ethyl butyrate | | butyrate ester | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 12-hydroxy stearic acid | | hydroxyoctadecanoic acid;
secondary alcohol | bacterial xenobiotic metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methyl caproate | | fatty acid methyl ester;
hexanoate ester | flavouring agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| propanethiol | | alkanethiol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| allyl alcohol | | primary allylic alcohol;
propenol | antibacterial agent;
fungicide;
herbicide;
insecticide;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isoamylamine | | primary aliphatic amine | bacterial metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-pentanone | | methyl ketone;
pentanone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methylcyclohexane | | cycloalkane;
volatile organic compound | aprotic solvent;
human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-pentanoic acid | | short-chain fatty acid;
straight-chain saturated fatty acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| propyl acetate | | acetate ester | fragrance;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| allyl cyanide | | aliphatic nitrile;
olefinic compound | antifeedant;
neurotoxin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ethyl formate | | ethyl ester;
formate ester | fumigant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pentanal | | saturated fatty aldehyde | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| piperidine | | azacycloalkane;
piperidines;
saturated organic heteromonocyclic parent;
secondary amine | base;
catalyst;
human metabolite;
non-polar solvent;
plant metabolite;
protic solvent;
reagent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| heptanoic acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1-hexanol | | hexanol;
primary alcohol | alarm pheromone;
antibacterial agent;
fragrance;
plant metabolite | 2012 | 2020 | 8.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| ethyl stearate | | long-chain fatty acid ethyl ester;
octadecanoate ester | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| heptanol | | heptanol;
primary alcohol | flavouring agent;
fragrance;
gap junctional intercellular communication inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| nonane | | alkane | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pelargonic acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
antifeedant;
Daphnia magna metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| undecan-2-one | | dialkyl ketone;
methyl ketone | plant metabolite;
rodenticide | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| octyl acetate | | acetate ester | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| decanaldehyde | | medium-chain fatty aldehyde;
n-alkanal;
saturated fatty aldehyde | antifungal agent;
fragrance;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-dodecane | | alkane | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| undecan-1-ol | | primary alcohol;
undecanol | flavouring agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| undecanal | | medium-chain fatty aldehyde;
n-alkanal;
saturated fatty aldehyde | antimycobacterial drug;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dodecanol | | dodecanol;
primary alcohol | bacterial metabolite;
cosmetic;
insect attractant;
insecticide;
pheromone;
plant metabolite | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 1-tridecanol | | long-chain primary fatty alcohol;
tridecanol | bacterial metabolite;
human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| myristyl alcohol | | long-chain primary fatty alcohol;
tetradecanol | pheromone;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| behenic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| stearyl alcohol | | long-chain primary fatty alcohol;
octadecanol | algal metabolite;
human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| eicosane | | long-chain alkane | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3-hydroxy-3-methylbutene | | olefinic compound;
tertiary alcohol | animal metabolite;
fragrance;
pheromone;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3,4,5-trimethoxybenzoic acid | | benzoic acids;
methoxybenzenes | human urinary metabolite;
human xenobiotic metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-chlorobenzoic acid | | 2-halobenzoic acid;
monochlorobenzoic acid | plant hormone;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| scoparone | | aromatic ether;
coumarins | anti-allergic agent;
anti-inflammatory agent;
antihypertensive agent;
antilipemic drug;
immunosuppressive agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dimethoxyphenylethylamine | | alkaloid;
aromatic ether;
phenylethylamine | allergen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ethyl-p-hydroxybenzoate | | ethyl ester;
paraben | antifungal agent;
antimicrobial food preservative;
phytoestrogen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| piperonal | | arenecarbaldehyde;
benzodioxoles | fragrance;
insect repellent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| vanillic acid | | methoxybenzoic acid;
monohydroxybenzoic acid | plant metabolite | 2002 | 2022 | 13.0 | low | 0 | 0 | 0 | 2 | 1 | 1 |
| peucedanin | | aromatic ether;
furanocoumarin;
lactone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| indolebutyric acid | | indol-3-yl carboxylic acid | auxin;
plant hormone;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| syringaldehyde | | dimethoxybenzene;
hydroxybenzaldehyde | hypoglycemic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-aminothiophenol | | aryl thiol;
substituted aniline | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| shikimic acid | | alpha,beta-unsaturated monocarboxylic acid;
cyclohexenecarboxylic acid;
hydroxy monocarboxylic acid | Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| estragole | | alkenylbenzene;
monomethoxybenzene;
phenylpropanoid | carcinogenic agent;
flavouring agent;
genotoxin;
insect attractant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| citronellol | | monoterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ethyl acetoacetate | | ethyl ester | antibacterial agent;
flavouring agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-hydroxypyridine | | monohydroxypyridine | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| hexanoic acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-heptane | | alkane;
volatile organic compound | non-polar solvent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1-nonanol | | nonanol;
primary alcohol | antifungal agent;
flavouring agent;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-vanillin | | benzaldehydes;
guaiacols | antimutagen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| citronellyl acetate | | acetate ester;
monoterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| catechin | | catechin | antioxidant;
plant metabolite | 1997 | 2021 | 16.6 | low | 0 | 0 | 4 | 11 | 4 | 2 |
| chrysene | | ortho-fused polycyclic arene | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| azulene | | azulenes;
mancude carbobicyclic parent;
ortho-fused bicyclic arene | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ephedrine | | phenethylamine alkaloid;
phenylethanolamines | bacterial metabolite;
environmental contaminant;
nasal decongestant;
plant metabolite;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pseudoephedrine hydrochloride | | hydrochloride | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| galantamine | | benzazepine alkaloid fundamental parent;
benzazepine alkaloid;
organic heterotetracyclic compound;
tertiary amino compound | antidote to curare poisoning;
cholinergic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| citrulline | | amino acid zwitterion;
citrulline | Daphnia magna metabolite;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
protective agent;
Saccharomyces cerevisiae metabolite | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 4-methylcatechol | | methylcatechol | antioxidant;
carcinogenic agent;
hapten;
human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| beta-erythroidine | | delta-lactone;
indole alkaloid;
organic heterotetracyclic compound;
tertiary amino compound | muscle relaxant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glycyrrhetinic acid | | cyclic terpene ketone;
hydroxy monocarboxylic acid;
pentacyclic triterpenoid | immunomodulator;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pinane | | carbobicyclic compound;
monoterpene;
terpenoid fundamental parent | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| naphthazarin | | hydroxy-1,4-naphthoquinone | acaricide;
antibacterial agent;
antineoplastic agent;
apoptosis inducer;
geroprotector;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| aloe emodin | | aromatic primary alcohol;
dihydroxyanthraquinone | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| chrysophanic acid | | dihydroxyanthraquinone | anti-inflammatory agent;
antiviral agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| emetine | | isoquinoline alkaloid;
pyridoisoquinoline | antiamoebic agent;
anticoronaviral agent;
antiinfective agent;
antimalarial;
antineoplastic agent;
antiprotozoal drug;
antiviral agent;
autophagy inhibitor;
emetic;
expectorant;
plant metabolite;
protein synthesis inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| reticulin | | benzylisoquinoline alkaloid;
benzyltetrahydroisoquinoline;
isoquinolinol | plant metabolite | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| cytisine | | alkaloid;
bridged compound;
lactam;
organic heterotricyclic compound;
secondary amino compound | nicotinic acetylcholine receptor agonist;
phytotoxin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| indole-3-carbaldehyde | | heteroarenecarbaldehyde;
indole alkaloid;
indoles | bacterial metabolite;
human xenobiotic metabolite;
marine metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| thymoquinone | | 1,4-benzoquinones | adjuvant;
anti-inflammatory agent;
antidepressant;
antineoplastic agent;
antioxidant;
cardioprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| phenylpropanolamine | | amphetamines;
phenethylamine alkaloid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-hydroxyphenylethanol | | phenols | anti-arrhythmia drug;
antioxidant;
cardiovascular drug;
fungal metabolite;
geroprotector;
plant metabolite;
protective agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| phloretic acid | | hydroxy monocarboxylic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| citronellic acid | | medium-chain fatty acid;
monoterpenoid;
monounsaturated fatty acid | flavouring agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isovaleric acid | | branched-chain saturated fatty acid;
methylbutyric acid;
short-chain fatty acid | mammalian metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| iberin | | isothiocyanate;
sulfoxide | apoptosis inducer;
plant metabolite;
quorum sensing inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 16-hydroxypalmitic acid | | hydroxypalmitic acid;
omega-hydroxy-long-chain fatty acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| arachidic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| octacosanoic acid | | straight-chain saturated fatty acid;
ultra-long-chain fatty acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| oleanolic acid | | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | plant metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ascaridole | | organic heterobicyclic compound;
organic peroxide;
p-menthane monoterpenoid | antileishmanial agent;
antinematodal drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| abietic acid | | abietane diterpenoid;
monocarboxylic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| hematoxylin | | organic heterotetracyclic compound;
oxacycle;
polyphenol;
tertiary alcohol | histological dye;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| podophyllotoxin | | furonaphthodioxole;
lignan;
organic heterotetracyclic compound | antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pyridoxamine dihydrochloride | | hydrochloride;
vitamin B6 | Escherichia coli metabolite;
human metabolite;
iron chelator;
mouse metabolite;
nephroprotective agent;
plant metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tryptophol | | indolyl alcohol | auxin;
plant metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| hemimellitene | | trimethylbenzene | neurotoxin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-methylbenzaldehyde | | tolualdehyde | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| syringic acid | | benzoic acids;
dimethoxybenzene;
phenols | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 6-methoxybenzoxazolinone | | aromatic ether;
benzoxazole | antibacterial agent;
anticonvulsant;
antifungal agent;
muscle relaxant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1,1-dimethoxyethane | | acetal;
diether | flavouring agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-methylfuran | | furans;
volatile organic compound | flavouring agent;
fuel;
hepatotoxic agent;
human urinary metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| perillyl alcohol | | limonene monoterpenoid | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cumic acid | | cumic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tricaprylin | | octanoate ester;
triglyceride | anticonvulsant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| senecioic acid | | alpha,beta-unsaturated monocarboxylic acid;
methyl-branched fatty acid;
monounsaturated fatty acid;
short-chain fatty acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3-hexen-1-ol | | alkenyl alcohol;
homoallylic alcohol;
primary alcohol;
volatile organic compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-hexadecane | | long-chain alkane | non-polar solvent;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| beta-phellandrene | | phellandrene | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tristearin | | triacylglycerol 54:0 | Caenorhabditis elegans metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| lignoceric acid | | straight-chain saturated fatty acid;
very long-chain fatty acid | Daphnia tenebrosa metabolite;
human metabolite;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-methyl-1-(1-methylethyl)-3-cyclohexen-1-ol | | terpineol;
tertiary alcohol | anti-inflammatory agent;
antibacterial agent;
antineoplastic agent;
antioxidant;
antiparasitic agent;
apoptosis inducer;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 6-methylsalicylic acid | | monohydroxybenzoic acid | Penicillium metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1-phenyl-1,2-propanedione | | alpha-diketone;
aromatic ketone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-methylcyclohexanone | | cyclohexanones | flavouring agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| terpinolene | | p-menthadiene | insect repellent;
plant metabolite;
sedative;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isovalerylaldehyde | | methylbutanal | flavouring agent;
plant metabolite;
Saccharomyces cerevisiae metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| levulinic acid | | oxopentanoic acid;
straight-chain saturated fatty acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-tridecanone | | methyl ketone | flavouring agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| octadecane | | long-chain alkane | bacterial metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dimethylselenide | | organoselenium compound | bacterial xenobiotic metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| chorismic acid | | 5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohexa-1,3-diene-1-carboxylic acid | Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-methyl-5-(1-methylethenyl)cyclohexanol | | p-menthane monoterpenoid;
secondary alcohol | acaricide;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-carboxybenzaladehyde | | benzaldehydes;
benzoic acids;
monocarboxylic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3-methylbenzaldehyde | | tolualdehyde | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isovanillin | | benzaldehydes;
monomethoxybenzene;
phenols | animal metabolite;
antidiarrhoeal drug;
antifungal agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
HIV protease inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2,5-dimethylfuran | | furans | antifungal agent;
bacterial metabolite;
fuel;
fumigant;
human urinary metabolite;
Maillard reaction product;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-hexanol | | hexanol;
secondary alcohol | human metabolite;
plant metabolite;
semiochemical | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ethyl palmitate | | hexadecanoate ester;
long-chain fatty acid ethyl ester | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-nonanol | | nonanol;
secondary alcohol | bacterial metabolite;
flavouring agent;
pheromone;
plant metabolite;
rat metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-propyl disulfide | | organic disulfide | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tridecane | | long-chain alkane | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-tetradecane | | long-chain alkane | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pentadecane | | long-chain alkane | animal metabolite;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| heptadecane | | long-chain alkane | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| nonadecane | | long-chain alkane | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-heneicosane | | long-chain alkane | pheromone;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| docosane | | long-chain alkane | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| octacosane | | long-chain alkane | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| nonacosane | | long-chain alkane | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| bulbocapnine | | aporphine alkaloid;
aromatic ether;
oxacycle;
phenols | EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitor;
EC 1.4.3.22 (diamine oxidase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1,2,3-trimethoxybenzene | | methoxybenzenes | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-pyrrolecarboxylic acid | | pyrrolecarboxylic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tridecanoic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-tricosane | | long-chain alkane | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-propylphenol | | phenols | flavouring agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isovanillic acid | | methoxybenzoic acid;
monohydroxybenzoic acid | antibacterial agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tetracosane | | long-chain alkane | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| docosanol | | docosanol;
long-chain primary fatty alcohol | antiviral drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-methylpyrrolidine | | pyrrolidines | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-nonanone | | methyl ketone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ethyl gallate | | gallate ester | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3-methylfuran | | furans;
volatile organic compound | Aspergillus metabolite;
environmental contaminant;
fungal metabolite;
Penicillium metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pentadecanoic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
food component;
human blood serum metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dihydroferulic acid | | guaiacols;
monocarboxylic acid;
phenylpropanoid | antioxidant;
human xenobiotic metabolite;
mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| fenchone, (+-)-isomer | | carbobicyclic compound;
cyclic terpene ketone;
fenchane monoterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| beta-pinene | | pinene | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glycyrrhizic acid | | enone;
glucosiduronic acid;
pentacyclic triterpenoid;
tricarboxylic acid;
triterpenoid saponin | EC 3.4.21.5 (thrombin) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| d-alpha tocopherol | | alpha-tocopherol | algal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite | 1946 | 2023 | 24.7 | low | 13 | 29 | 83 | 66 | 36 | 3 |
| selenomethionine | | selenoamino acid;
selenomethionines | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1-pentene-3-one | | enone | flavouring agent;
genotoxin;
human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dodecyldimethylamine oxide | | tertiary amine oxide | detergent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-undecanol | | secondary alcohol;
undecanol | animal metabolite;
flavouring agent;
pheromone;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| digoxigenin | | 12beta-hydroxy steroid;
14beta-hydroxy steroid;
3beta-hydroxy steroid;
3beta-sterol | hapten;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| heliamine | | aromatic ether;
diether;
isoquinoline alkaloid;
isoquinolines | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 6h-dibenzo-(b,d)-pyran-6-one | | benzochromenone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| diallyl disulfide | | organic disulfide | antifungal agent;
antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glaucine | | aporphine alkaloid;
organic heterotetracyclic compound;
polyether;
tertiary amino compound | antibacterial agent;
antineoplastic agent;
antitussive;
muscle relaxant;
NF-kappaB inhibitor;
plant metabolite;
platelet aggregation inhibitor;
rat metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dihydroconiferyl alcohol | | eugenol;
primary alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| propyl benzoate | | benzoate ester | antimicrobial food preservative;
flavouring agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-methoxy-1,4-naphthoquinone | | 1,4-naphthoquinones;
enol ether | antimicrobial agent;
metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tricosanoic acid | | straight-chain saturated fatty acid;
very long-chain fatty acid | Daphnia magna metabolite;
human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| alpha-terpineol | | terpineol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| acetosyringone | | acetophenones;
dimethoxybenzene;
phenols | anti-asthmatic drug;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pentadecanal | | 2,3-saturated fatty aldehyde;
long-chain fatty aldehyde | antimicrobial agent;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-ethylfuran | | furans;
volatile organic compound | bacterial metabolite;
fragrance;
Maillard reaction product;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sabinene | | thujene | plant metabolite | 2002 | 2023 | 12.2 | low | 0 | 0 | 0 | 4 | 0 | 2 |
| palmatine | | berberine alkaloid;
organic heterotetracyclic compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-butylbenzenesulfonamide | | sulfonamide | neurotoxin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| furaneol | | cyclic ketone;
enol;
furans | flavouring agent;
fragrance;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methyl vanillate | | aromatic ether;
benzoate ester;
phenols | antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-octanol | | octanol;
secondary alcohol | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5-methoxyindole-2-carboxylic acid | | aromatic ether;
indolecarboxylic acid | EC 1.8.1.4 (dihydrolipoyl dehydrogenase) inhibitor;
hypoglycemic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| canadine, (s)-isomer | | an (S)-7,8,13,14-tetrahydroprotoberberine;
canadine | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 14-methylhexadecanoic acid | | branched-chain saturated fatty acid;
long-chain fatty acid;
methyl-branched fatty acid | mammalian metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| helenalin | | cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
secondary alcohol;
sesquiterpene lactone | anti-inflammatory agent;
antineoplastic agent;
metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dimethyldiselenide | | organoselenium compound | bacterial metabolite;
human xenobiotic metabolite;
mammalian metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| camptothecin | | delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol | antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isopentenyladenosine | | N-ribosyl-N(6)-isopentenyladenine;
nucleoside analogue | antineoplastic agent;
plant growth regulator;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| s-methylcysteine | | S-alkyl-L-cysteine zwitterion;
S-alkyl-L-cysteine | human urinary metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dihydrocarvone | | dihydrocarvones | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| marmesin, (r)-isomer | | marmesin | plant metabolite;
rat metabolite;
xenobiotic metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-hydroxybenzylcyanide | | hydroxynitrile | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2,3,5-trimethylpyrazine | | pyrazines | animal metabolite;
bacterial metabolite;
flavouring agent;
pheromone;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tetradecanoylphorbol acetate | | acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester | antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator | 1982 | 2011 | 28.2 | low | 0 | 5 | 20 | 7 | 1 | 0 |
| 2,4-dihydroxy-1,4-benzoxazin-3-one | | benzoxazine;
cyclic hydroxamic acid;
lactol | allelochemical;
herbicide;
phytotoxin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| precocene i | | aromatic ether;
chromenes | plant metabolite;
precocenes | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1-deoxynojirimycin | | 2-(hydroxymethyl)piperidine-3,4,5-triol;
piperidine alkaloid | anti-HIV agent;
anti-obesity agent;
bacterial metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
plant metabolite | 1990 | 1990 | 34.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| neohesperidin dihydrochalcone | | dihydrochalcones;
disaccharide derivative;
neohesperidoside | environmental contaminant;
plant metabolite;
sweetening agent;
xenobiotic | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| zingerone | | methyl ketone;
monomethoxybenzene;
phenols | anti-inflammatory agent;
antiemetic;
antioxidant;
flavouring agent;
fragrance;
plant metabolite;
radiation protective agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-anisaldehyde | | benzaldehydes | bacterial metabolite;
human urinary metabolite;
insect repellent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| myrcene | | monoterpene | anabolic agent;
anti-inflammatory agent;
flavouring agent;
fragrance;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| diacetone alcohol | | beta-hydroxy ketone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methyl tetradecanoate | | fatty acid methyl ester | flavouring agent;
fragrance;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| nonanal | | medium-chain fatty aldehyde;
n-alkanal;
saturated fatty aldehyde | human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tetradecanal | | 2,3-saturated fatty aldehyde;
long-chain fatty aldehyde | bacterial metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| silybin | | aromatic ether;
benzodioxine;
flavonolignan;
polyphenol;
secondary alpha-hydroxy ketone | antineoplastic agent;
antioxidant;
hepatoprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| oxypeucadanin, (s)-(-)-isomer | | epoxide;
furanocoumarin;
lactone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| amygdalin | | cyanogenic glycoside;
disaccharide derivative;
gentiobioside | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| colforsin | | acetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol | adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist | 1984 | 2001 | 28.0 | low | 0 | 1 | 4 | 2 | 0 | 0 |
| swainsonine | | indolizidine alkaloid | antineoplastic agent;
EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) inhibitor;
immunological adjuvant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| octyl gallate | | gallate ester | food antioxidant;
hypoglycemic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| vanillyl alcohol | | benzyl alcohols;
guaiacols | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| benzylaminopurine | | 6-aminopurines | cytokinin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| allyl methyl disulfide | | organic disulfide | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| octyl glucoside | | beta-D-glucoside | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dihydrochalcone | | dihydrochalcones | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ursolic acid | | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | geroprotector;
plant metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| betulinic acid | | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| calanolide a | | cyclic ether;
delta-lactone;
organic heterotetracyclic compound;
secondary alcohol | HIV-1 reverse transcriptase inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| baicalin | | dihydroxyflavone;
glucosiduronic acid;
glycosyloxyflavone;
monosaccharide derivative | antiatherosclerotic agent;
antibacterial agent;
anticoronaviral agent;
antineoplastic agent;
antioxidant;
cardioprotective agent;
EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
ferroptosis inhibitor;
neuroprotective agent;
non-steroidal anti-inflammatory drug;
plant metabolite;
prodrug | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| epigallocatechin gallate | | flavans;
gallate ester;
polyphenol | antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| aica ribonucleotide | | 1-(phosphoribosyl)imidazolecarboxamide;
aminoimidazole | cardiovascular drug;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| salvin | | abietane diterpenoid;
carbotricyclic compound;
catechols;
monocarboxylic acid | angiogenesis modulating agent;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
food preservative;
HIV protease inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose | | gallate ester;
galloyl beta-D-glucose | anti-inflammatory agent;
antineoplastic agent;
geroprotector;
hepatoprotective agent;
plant metabolite;
radiation protective agent;
radical scavenger | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| obtusifoliol | | 14alpha-methyl steroid;
3beta-sterol | mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| baccatin iii | | acetate ester;
benzoate ester;
tetracyclic diterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| secoisolariciresinol | | secoisolariciresinol | antidepressant;
phytoestrogen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| solanidine | | 3beta-hydroxy-Delta(5)-steroid;
solanid-5-en-3-ol;
steroid alkaloid fundamental parent | plant metabolite;
toxin | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| valerophenone | | aromatic ketone | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2,4,6-trihydroxyacetophenone | | aromatic ketone;
benzenetriol;
methyl ketone | MALDI matrix material;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tangeretin | | pentamethoxyflavone | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| djenkolic acid | | dithioacetal;
L-cysteine derivative;
non-proteinogenic L-alpha-amino acid | plant metabolite;
toxin | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1-hexacosanol | | hexacosanol;
very long-chain primary fatty alcohol | insecticide;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| actinidine | | cyclopentapyridine;
pyridine alkaloid | pheromone;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 7-methylxanthine | | oxopurine;
purine alkaloid | human xenobiotic metabolite;
mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1-octacosanol | | fatty alcohol 28:0;
ultra-long-chain primary fatty alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| suberosin | | aromatic ether;
coumarins | anticoagulant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| artemisinin | | organic peroxide;
sesquiterpene lactone | antimalarial;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isoscopoletin | | aromatic ether;
hydroxycoumarin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methyl syringate | | benzoate ester;
dimethoxybenzene;
phenols | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gallocatechol | | catechin;
flavan-3,3',4',5,5',7-hexol | antioxidant;
food component;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| hesperetin | | 3'-hydroxyflavanones;
4'-methoxyflavanones;
monomethoxyflavanone;
trihydroxyflavanone | antineoplastic agent;
antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sesamin | | benzodioxoles;
furofuran;
lignan | antineoplastic agent;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tetrahydroalstonine | | methyl ester;
organic heteropentacyclic compound;
yohimban alkaloid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| nobiletin | | methoxyflavone | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| lycorine | | indolizidine alkaloid | anticoronaviral agent;
antimalarial;
plant metabolite;
protein synthesis inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| picropodophyllin | | furonaphthodioxole;
lignan;
organic heterotetracyclic compound | antineoplastic agent;
insulin-like growth factor receptor 1 antagonist;
plant metabolite;
tyrosine kinase inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| alantolactone | | naphthofuran;
olefinic compound;
sesquiterpene lactone | antineoplastic agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| vexibinol | | (2S)-flavan-4-one;
4'-hydroxyflavanones;
tetrahydroxyflavanone | antimalarial;
antimicrobial agent;
antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| kaurenoic acid | | ent-kaurane diterpenoid | anti-HIV-1 agent;
antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| beta-amyrin | | pentacyclic triterpenoid;
secondary alcohol | Aspergillus metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pinostrobin | | monohydroxyflavanone;
monomethoxyflavanone | antidote;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| xanthomicrol | | dihydroxyflavone;
trimethoxyflavone | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| voacamine | | alkaloid ester;
methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound;
tertiary amino compound | angiogenesis inhibitor;
antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isoalantolactone | | eudesmane sesquiterpenoid;
sesquiterpene lactone | antifungal agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pulsatilla saponin a | | disaccharide derivative;
hydroxy monocarboxylic acid;
pentacyclic triterpenoid;
triterpenoid saponin | anti-inflammatory agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| hederagenin | | dihydroxy monocarboxylic acid;
pentacyclic triterpenoid;
sapogenin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| magnoflorine | | aporphine alkaloid;
quaternary ammonium ion | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| brazilin | | catechols;
organic heterotetracyclic compound;
tertiary alcohol | anti-inflammatory agent;
antibacterial agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
biological pigment;
hepatoprotective agent;
histological dye;
NF-kappaB inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| strychnine n-oxide | | monoterpenoid indole alkaloid;
organic heteroheptacyclic compound;
tertiary amine oxide | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pinoresinol | | pinoresinol | hypoglycemic agent;
phytoestrogen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dauricine | | aromatic ether;
bisbenzylisoquinoline alkaloid;
isoquinolines;
phenols;
tertiary amino compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| madecassic acid | | monocarboxylic acid;
pentacyclic triterpenoid;
tetrol | antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| uvaretin | | aromatic ether;
dihydrochalcones;
polyketide;
resorcinol | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| fangchinoline | | aromatic ether;
bisbenzylisoquinoline alkaloid;
macrocycle | anti-HIV-1 agent;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sakuranetin | | (2S)-flavan-4-one;
4'-hydroxyflavanones;
dihydroxyflavanone;
flavonoid phytoalexin;
monomethoxyflavanone | antimycobacterial drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| maslinic acid | | dihydroxy monocarboxylic acid;
pentacyclic triterpenoid | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| indole-5-carboxylic acid | | indolecarboxylic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1,3,7,9-tetramethyluric acid | | oxopurine;
purine alkaloid | analgesic;
anti-inflammatory agent;
human xenobiotic metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| phenylalanylleucine | | dipeptide zwitterion;
dipeptide | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ethyl protocatechuate | | catechols;
ethyl ester | antibacterial agent;
antioxidant;
apoptosis inducer;
EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3,5-dimethoxytoluene | | methoxybenzenes;
toluenes | fragrance;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methylthioethanol | | aliphatic sulfide;
primary alcohol | plant metabolite;
xenobiotic metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cryptolepine | | indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound | anti-inflammatory agent;
antimalarial;
antineoplastic agent;
cysteine protease inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| alpha-bergamotene | | bridged compound;
polycyclic olefin;
sesquiterpene | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| loganin | | beta-D-glucoside;
cyclopentapyran;
enoate ester;
iridoid monoterpenoid;
methyl ester;
monosaccharide derivative;
secondary alcohol | anti-inflammatory agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
EC 3.4.23.46 (memapsin 2) inhibitor;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-methyl-4-sulfanylpentan-2-one | | alkanethiol;
methyl ketone | plant metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5,7-dimethoxyflavone | | dimethoxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| nicotine | | 3-(1-methylpyrrolidin-2-yl)pyridine | anxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic | 2005 | 2008 | 17.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| loganic acid | | alpha,beta-unsaturated monocarboxylic acid;
cyclopentapyran;
glucoside | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| friedelin | | cyclic terpene ketone;
pentacyclic triterpenoid | anti-inflammatory drug;
antipyretic;
non-narcotic analgesic;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cholest-4-en-3-one | | 3-oxo-Delta(4) steroid;
cholestanoid | human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| delta-tocopherol | | tocopherol;
vitamin E | food antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cycloartenol | | 3beta-sterol;
pentacyclic triterpenoid;
phytosterols | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| beta-peltatin | | furonaphthodioxole;
gamma-lactone;
lignan;
organic heterotetracyclic compound;
phenols | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| elemol | | olefinic compound;
sesquiterpenoid;
tertiary alcohol | fragrance;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| spathulenol | | carbotricyclic compound;
olefinic compound;
sesquiterpenoid;
tertiary alcohol | anaesthetic;
plant metabolite;
vasodilator agent;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| mor-14 | | hydroxypiperidine;
piperidine alkaloid;
tertiary amino compound | anti-HIV agent;
cardioprotective agent;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| vestitol | | aromatic ether;
hydroxyisoflavans;
methoxyisoflavan | anti-inflammatory agent;
phytoalexin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gamma-tocopherol | | tocopherol;
vitamin E | algal metabolite;
food antioxidant;
plant metabolite | 2004 | 2020 | 11.2 | low | 0 | 0 | 0 | 2 | 4 | 0 |
| orotidine | | nucleoside;
pyrimidinemonocarboxylic acid;
uridines | bacterial metabolite;
fungal metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sugiol | | abietane diterpenoid;
carbotricyclic compound;
cyclic terpene ketone;
meroterpenoid;
phenols | antineoplastic agent;
antioxidant;
antiviral agent;
plant metabolite;
radical scavenger | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| erythrose | | erythrose | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 24-methylene cycloartanol | | 3beta-hydroxy steroid;
pentacyclic triterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| panose | | trisaccharide | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| bursehernin | | aromatic ether;
benzodioxoles;
butan-4-olide;
lignan | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sesaminol | | benzodioxoles;
furofuran;
organic hydroxy compound | antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4',5,6,7-tetramethoxyflavone | | tetramethoxyflavone | antimutagen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gardenin b | | monohydroxyflavone;
tetramethoxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| quercetin 5,7,3',4'-tetramethyl ether | | flavonols;
tetramethoxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid | | alpha-amino acid;
aromatic amino acid;
beta-carboline alkaloid | human urinary metabolite;
human xenobiotic metabolite;
plant metabolite;
rat metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sarsasapogenin, (3beta,5alpha,25r)-isomer | | sapogenin | gout suppressant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| syringaresinol | | aromatic ether;
furofuran;
lignan;
polyether;
polyphenol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cyclolaudenol | | 3beta-hydroxy steroid;
pentacyclic triterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| galgravin | | aryltetrahydrofuran;
dimethoxybenzene;
lignan;
ring assembly | bone density conservation agent;
neuroprotective agent;
plant metabolite;
platelet aggregation inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| erythrodiol | | diol;
pentacyclic triterpenoid;
primary alcohol;
secondary alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 6,6-dimethyl-2-methylenebicyclo(3.1.1)heptan-3-ol | | carbobicyclic compound;
pinane monoterpenoid;
secondary alcohol | GABA modulator;
mouse metabolite;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| selenomethionine | | amino acid zwitterion;
selenomethionine | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| deguelin | | aromatic ether;
diether;
organic heteropentacyclic compound;
rotenones | angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
apoptosis inducer;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
mitochondrial NADH:ubiquinone reductase inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1,9-dideoxyforskolin | | acetate ester;
labdane diterpenoid;
organic heterotricyclic compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| daidzin | | 7-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
monosaccharide derivative | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| triptolide | | diterpenoid;
epoxide;
gamma-lactam;
organic heteroheptacyclic compound | antispermatogenic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| indospicine | | carboxamidine;
non-proteinogenic L-alpha-amino acid | hepatotoxic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cafestol | | diterpenoid;
furans;
organic heteropentacyclic compound;
primary alcohol;
tertiary alcohol | angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
hypoglycemic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| nimbin | | acetate ester;
cyclic terpene ketone;
enone;
furans;
limonoid;
methyl ester;
tetracyclic triterpenoid | pesticide;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| neoeriocitrin | | 4'-hydroxyflavanones;
disaccharide derivative;
flavanone glycoside;
neohesperidoside;
trihydroxyflavanone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| kahweol | | diterpenoid;
furans;
organic heteropentacyclic compound;
primary alcohol;
tertiary alcohol | angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| valerates | | short-chain fatty acid anion;
straight-chain saturated fatty acid anion | plant metabolite | 1990 | 2006 | 26.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| liquiritigenin | | 4',7-dihydroxyflavanone | hormone agonist;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| s-sulphocysteine | | organic thiosulfate;
S-substituted L-cysteine | human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| megestrol acetate | | bridged compound;
organic heterotetracyclic compound;
secondary alcohol;
sesquiterpene lactone;
spiro compound;
tertiary alcohol;
tetrol | GABA antagonist;
neurotoxin;
phytogenic insecticide;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| stachydrine | | alkaloid;
amino-acid betaine;
N-methyl-L-alpha-amino acid | food component;
human blood serum metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| echinuline | | 2,5-diketopiperazines;
indole alkaloid;
indoles;
olefinic compound | Aspergillus metabolite;
marine metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cubebin | | benzodioxoles;
cyclic acetal;
lactol;
lignan;
secondary alcohol | analgesic;
anti-inflammatory agent;
antimicrobial agent;
histamine antagonist;
plant metabolite;
trypanocidal drug | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1'-acetoxychavicol acetate | | acetate ester;
phenylpropanoid | antineoplastic agent;
NF-kappaB inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| hydrangenol | | dihydroisocoumarins;
phenols | anti-allergic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| matairesinol | | gamma-lactone;
lignan;
polyphenol | angiogenesis inhibitor;
anti-asthmatic agent;
phytoestrogen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| astilbin | | 3'-hydroxyflavanones;
4'-hydroxyflavanones;
alpha-L-rhamnoside;
flavanone glycoside;
monosaccharide derivative;
tetrahydroxyflavanone | anti-inflammatory agent;
plant metabolite;
radical scavenger | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ginsenoside rh2 | | 12beta-hydroxy steroid;
20-hydroxy steroid;
beta-D-glucoside;
ginsenoside;
tetracyclic triterpenoid | antineoplastic agent;
apoptosis inducer;
bone density conservation agent;
cardioprotective agent;
hepatoprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| mannopine | | amino acid opine;
dicarboxylic acid monoamide;
hexitol derivative;
L-glutamine derivative;
non-proteinogenic L-alpha-amino acid;
secondary amino compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ribulose-1,5 diphosphate | | ribulose phosphate | Escherichia coli metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| swertisin | | dihydroxyflavone;
flavone C-glycoside;
monomethoxyflavone;
monosaccharide derivative;
polyphenol | adenosine A1 receptor antagonist;
anti-inflammatory agent;
antioxidant;
hypoglycemic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| senegalensin | | (2S)-flavan-4-one;
4'-hydroxyflavanones;
trihydroxyflavanone | antibacterial agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glabranin | | (2S)-flavan-4-one;
dihydroxyflavanone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| rubiadin | | dihydroxyanthraquinone | antibacterial agent;
antioxidant;
hepatoprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| soranjidiol | | dihydroxyanthraquinone | antibacterial agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| skullcapflavone ii | | dihydroxyflavone;
tetramethoxyflavone | anti-asthmatic drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| rubimaillin | | benzochromene;
methyl ester;
phenols | acyl-CoA:cholesterol acyltransferase 2 inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
neuroprotective agent;
NF-kappaB inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tiglic acid | | 2-methylbut-2-enoic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| psorospermin | | epoxide;
organic heterotetracyclic compound;
xanthones | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| delphinidin | | 5-hydroxyanthocyanidin | antineoplastic agent;
biological pigment;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sinensetin | | pentamethoxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-methylserotonin | | phenols;
tryptamines | human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| lyxonic acid | | lyxonic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| kolaviron | | 4'-methoxyflavanones;
biflavonoid;
dihydroflavonols;
ring assembly;
secondary alpha-hydroxy ketone | hepatoprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| spinosin | | dihydroxyflavone;
flavone C-glycoside;
monomethoxyflavone | anxiolytic drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| schizandrin b | | aromatic ether;
cyclic acetal;
organic heterotetracyclic compound;
oxacycle;
tannin | anti-asthmatic agent;
anti-inflammatory agent;
antilipemic drug;
antioxidant;
apoptosis inhibitor;
hepatoprotective agent;
nephroprotective agent;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| acrovestone | | acetophenones;
aromatic ether;
olefinic compound;
polyphenol | antioxidant;
EC 1.14.18.1 (tyrosinase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cirsiliol | | dimethoxyflavone;
trihydroxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isosakuranetin | | (2S)-flavan-4-one;
4'-methoxyflavanones;
dihydroxyflavanone;
monomethoxyflavanone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| matteucinol | | 4'-methoxyflavanones;
dihydroxyflavanone;
monomethoxyflavanone | plant metabolite;
radical scavenger | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| guvacoline | | alpha,beta-unsaturated carboxylic ester;
beta-amino acid ester;
enoate ester;
methyl ester;
pyridine alkaloid;
secondary amino compound;
tetrahydropyridine | muscarinic agonist;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| corytuberine | | aporphine alkaloid;
aromatic ether;
organic heterotetracyclic compound;
polyphenol;
tertiary amino compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| actinodaphine | | aporphine alkaloid;
aromatic ether;
organic heteropentacyclic compound;
phenols;
secondary amino compound | antibacterial agent;
antifungal agent;
antineoplastic agent;
apoptosis inducer;
plant metabolite;
platelet aggregation inhibitor;
topoisomerase inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ar-turmerone | | enone;
sesquiterpenoid | EC 3.1.1.7 (acetylcholinesterase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isolariciresinol | | guaiacols;
lignan;
polyphenol;
primary alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4'-demethyldesoxypodophyllotoxin | | furonaphthodioxole;
gamma-lactone;
lignan;
methoxybenzenes;
phenols | antineoplastic agent;
antioxidant;
immunosuppressive agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| t-cadinol | | cadinane sesquiterpenoid;
carbobicyclic compound;
octahydronaphthalenes;
tertiary alcohol | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1-hydroxy-2-methylanthraquinone | | monohydroxyanthraquinone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| nevadensin | | dihydroxyflavone;
trimethoxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| salvigenin | | monohydroxyflavone;
trimethoxyflavone | antilipemic drug;
antineoplastic agent;
apoptosis inhibitor;
autophagy inducer;
hypoglycemic agent;
immunomodulator;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| secologanin | | aldehyde;
beta-D-glucoside;
enoate ester;
methyl ester;
pyrans;
secoiridoid glycoside | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| columbianetin acetate | | acetate ester;
furanocoumarin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| maprounic acid | | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | HIV-1 reverse transcriptase inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| acetyl aleuritolic acid | | acetate ester;
monocarboxylic acid;
pentacyclic triterpenoid | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| myricanone | | aromatic ether;
cyclic ketone;
diarylheptanoid;
methoxybenzenes;
phenols | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glycyrrhetyl 3-monoglucuronide | | beta-D-glucosiduronic acid;
enone;
monosaccharide derivative;
oxo dicarboxylic acid;
pentacyclic triterpenoid;
triterpenoid saponin | anti-allergic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
human xenobiotic metabolite;
plant metabolite;
sweetening agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| hydroxysitosterol | | 3beta-hydroxy-Delta(5)-steroid;
7alpha-hydroxy steroid | metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| capsidiol | | eremophilane sesquiterpenoid;
octahydronaphthalenes;
sesquiterpene phytoalexin | antifungal agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| phaseollin (isoflavan) | | hydroxyisoflavans | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cirsilineol | | dihydroxyflavone;
trimethoxyflavone | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| secoxyloganin | | beta-D-glucoside;
dicarboxylic acid monoester;
enoate ester;
methyl ester;
monosaccharide derivative;
pyrans;
secoiridoid glycoside | anti-allergic agent;
antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sclareol | | labdane diterpenoid | antifungal agent;
antimicrobial agent;
apoptosis inducer;
fragrance;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| butrin | | 4'-hydroxyflavanones;
flavanone glycoside;
monohydroxyflavanone | anti-inflammatory agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| diplopterol | | hopanoid;
pentacyclic triterpenoid;
tertiary alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| anacardic acid | | hydroxy monocarboxylic acid;
hydroxybenzoic acid | anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
apoptosis inducer;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| confertin | | cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
pseudoguaianolide | anti-inflammatory agent;
metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pluviatolide | | aromatic ether;
benzodioxoles;
butan-4-olide;
lignan;
phenols | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pectolinarin | | dimethoxyflavone;
disaccharide derivative;
glycosyloxyflavone;
monohydroxyflavanone;
rutinoside | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| albicanol | | carbobicyclic compound;
homoallylic alcohol;
primary alcohol;
sesquiterpenoid | antifeedant;
antifungal agent;
antineoplastic agent;
fungal metabolite;
mammalian metabolite;
marine metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| inuviscolide | | gamma-lactone;
organic heterotricyclic compound;
sesquiterpene lactone;
tertiary alcohol | anti-inflammatory agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| helioxanthin | | benzodioxoles;
furonaphthodioxole;
lignan | anti-HBV agent;
antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| (2S)-5,7-dihydroxy-6,8-dimethylflavanone | | dihydroxyflavanone | EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| medioresinol | | dimethoxybenzene;
furofuran;
lignan;
polyphenol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5-heptadecylresorcinol | | 5-alkylresorcinol | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| (+)-epicatechin | | catechin;
polyphenol | cyclooxygenase 1 inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| kobusin | | benzodioxoles;
dimethoxybenzene;
furofuran;
lignan | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| nootkatol | | 6-isopropenyl-4,4a-dimethyl-2,3,4,4a,5,6,7,8-octahydronaphthalen-2-ol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ergolide | | acetate ester;
cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
sesquiterpene lactone | anti-inflammatory agent;
antineoplastic agent;
metabolite;
NF-kappaB inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dihydroresveratrol | | stilbenol | plant metabolite;
xenobiotic metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glycitin | | 7-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
methoxyisoflavone;
monosaccharide derivative | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| benzyl d-glucopyranoside | | benzenes;
beta-D-glucoside | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| chrysosplenol c | | trihydroxyflavone;
trimethoxyflavone | antineoplastic agent;
antiviral agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5-o-methyllicoricidin | | aromatic ether;
hydroxyisoflavans;
methoxyisoflavan | antibacterial agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| (-)-gallocatechin gallate | | catechin;
gallate ester;
polyphenol | antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human xenobiotic metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pronuciferine | | aromatic ether;
cyclic ketone;
isoquinoline alkaloid;
isoquinolines;
organic heterotetracyclic compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| santonin | | botanical anti-fungal agent;
santonin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sandaracopimaric acid | | monocarboxylic acid;
pimarane diterpenoid;
tricyclic diterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sitosterol, (3beta)-isomer | | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
C29-steroid;
phytosterols;
stigmastane sterol | anticholesteremic drug;
antioxidant;
mouse metabolite;
plant metabolite;
sterol methyltransferase inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| erythritol | | butane-1,2,3,4-tetrol | antioxidant;
human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| stigmastanol | | 3-hydroxy steroid;
phytosterols | anticholesteremic drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| vincaleukoblastine | | acetate ester;
indole alkaloid fundamental parent;
methyl ester;
organic heteropentacyclic compound;
organic heterotetracyclic compound;
tertiary alcohol;
tertiary amino compound;
vinca alkaloid | antineoplastic agent;
immunosuppressive agent;
microtubule-destabilising agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3-octanone | | dialkyl ketone | antifeedant;
biomarker;
fungal metabolite;
human urinary metabolite;
insect attractant;
plant metabolite;
toxin | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| lanosterol | | 14alpha-methyl steroid;
3beta-sterol;
tetracyclic triterpenoid | bacterial metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| lupeol | | pentacyclic triterpenoid;
secondary alcohol | anti-inflammatory drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| noscapine | | aromatic ether;
benzylisoquinoline alkaloid;
cyclic acetal;
isobenzofuranone;
organic heterobicyclic compound;
organic heterotricyclic compound;
tertiary amino compound | antineoplastic agent;
antitussive;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| aromaticin | | cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
sesquiterpene lactone | anti-inflammatory agent;
metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methyl 3,4-dihydroxybenzoate | | catechols;
methyl ester | antioxidant;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-hydroxy-1,4-benzoxazin-3-one | | benzoxazine;
lactam;
lactol | allelochemical;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| menthofuran | | 1-benzofurans;
monoterpenoid | nematicide;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| lariciresinol | | aromatic ether;
lignan;
oxolanes;
phenols;
primary alcohol | antifungal agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| medicarpin | | medicarpin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| anthricin | | furonaphthodioxole;
gamma-lactone;
lignan;
methoxybenzenes | antineoplastic agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| indole-3-acetonitrile | | indoles;
nitrile | auxin;
human xenobiotic metabolite;
plant hormone;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| taiwanin c | | benzodioxoles;
furonaphthodioxole;
lignan | antineoplastic agent;
plant metabolite;
platelet aggregation inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sampangine | | alkaloid;
organic heterotetracyclic compound | antifungal agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isochamaejasmin | | biflavonoid;
hydroxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| norbelladine | | catechols;
phenethylamine alkaloid;
polyphenol;
secondary amino compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| canavanine | | amino acid zwitterion;
non-proteinogenic L-alpha-amino acid | phytogenic insecticide;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| raffinose | | raffinose family oligosaccharide;
trisaccharide | mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| naringenin | | (2S)-flavan-4-one;
naringenin | expectorant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5-hydroxytryptophan | | 5-hydroxytryptophan;
amino acid zwitterion;
hydroxy-L-tryptophan;
non-proteinogenic L-alpha-amino acid | human metabolite;
mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| theanine | | amino acid zwitterion;
N(5)-alkyl-L-glutamine | geroprotector;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ouabain | | 11alpha-hydroxy steroid;
14beta-hydroxy steroid;
5beta-hydroxy steroid;
alpha-L-rhamnoside;
cardenolide glycoside;
steroid hormone | anti-arrhythmia drug;
cardiotonic drug;
EC 2.3.3.1 [citrate (Si)-synthase] inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
ion transport inhibitor;
plant metabolite | 1986 | 1992 | 35.0 | low | 1 | 3 | 2 | 0 | 0 | 0 |
| scopolin | | beta-D-glucoside;
coumarins;
monosaccharide derivative | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| stachyose | | raffinose family oligosaccharide;
tetrasaccharide | mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isomaltulose | | glycosylfructose | animal metabolite;
plant metabolite;
sweetening agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| discretamine | | berberine alkaloid;
organic heterotetracyclic compound | EC 5.99.1.2 (DNA topoisomerase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| mimosine | | 4-pyridones;
amino acid zwitterion;
non-proteinogenic L-alpha-amino acid | EC 1.14.18.1 (tyrosinase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pelargonidin | | 5-hydroxyanthocyanidin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| (+)-limonene | | limonene | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| hygrine | | 1-(1-methylpyrrolidin-2-yl)acetone;
pyrrolidine alkaloid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| arbutin | | beta-D-glucoside;
monosaccharide derivative | Escherichia coli metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| conessine | | steroid alkaloid;
tertiary amino compound | antibacterial agent;
antimalarial;
H3-receptor antagonist;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| canaline | | amino acid zwitterion;
non-proteinogenic L-alpha-amino acid | antimetabolite;
antineoplastic agent;
phytogenic insecticide;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| norpseudoephedrine | | amphetamines;
phenethylamine alkaloid | central nervous system stimulant;
plant metabolite;
psychotropic drug | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sophoranone | | 4'-hydroxyflavanones;
dihydroxyflavanone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| petunidin | | 5-hydroxyanthocyanidin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glaucarubinone | | carboxylic ester;
organic heteropentacyclic compound;
quassinoid;
secondary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone;
tetrol | antimalarial;
antineoplastic agent;
geroprotector;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| helveticoside | | 14beta-hydroxy steroid;
5beta-hydroxy steroid;
cardenolide glycoside;
digitoxoside;
monosaccharide derivative;
steroid aldehyde;
steroid lactone | antineoplastic agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ginsenoside re | | 12beta-hydroxy steroid;
3beta-hydroxy-4,4-dimethylsteroid;
3beta-hydroxy steroid;
beta-D-glucoside;
disaccharide derivative;
ginsenoside;
tetracyclic triterpenoid | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
nephroprotective agent;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ginsenoside rf | | 12beta-hydroxy steroid;
20-hydroxy steroid;
3beta-hydroxy-4,4-dimethylsteroid;
3beta-hydroxy steroid;
beta-D-glucoside;
disaccharide derivative;
ginsenoside;
tetracyclic triterpenoid | antineoplastic agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3-o-(alpha-l-arabinopyranosyl)hederagenin | | alpha-L-arabinopyranoside;
hydroxy monocarboxylic acid;
monosaccharide derivative;
pentacyclic triterpenoid;
triterpenoid saponin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| notoginsenoside r1 | | 12beta-hydroxy steroid;
3beta-hydroxy-4,4-dimethylsteroid;
3beta-hydroxy steroid;
beta-D-glucoside;
disaccharide derivative;
ginsenoside;
tetracyclic triterpenoid | antioxidant;
apoptosis inducer;
neuroprotective agent;
phytoestrogen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-(2-phenylethyl)chromone | | benzenes;
chromones | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ferruginol | | abietane diterpenoid;
carbotricyclic compound;
meroterpenoid;
phenols | antibacterial agent;
antineoplastic agent;
plant metabolite;
protective agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| stevioside | | beta-D-glucoside;
bridged compound;
diterpene glycoside;
ent-kaurane diterpenoid;
tetracyclic diterpenoid | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
hypoglycemic agent;
plant metabolite;
sweetening agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| lenticin | | amino-acid betaine;
indole alkaloid;
L-tryptophan derivative | fungal metabolite;
plant metabolite;
xenobiotic | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| absynthin | | organic heteroheptacyclic compound;
sesquiterpene lactone;
triterpenoid | anti-inflammatory agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| abyssinone i | | monohydroxyflavanone;
phenols | apoptosis inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| afzelechin | | catechin;
tetrahydroxyflavan | EC 3.2.1.20 (alpha-glucosidase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| asebogenin | | dihydrochalcones | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| lactucin | | azulenofuran;
cyclic terpene ketone;
enone;
primary alcohol;
secondary alcohol;
sesquiterpene lactone | antimalarial;
plant metabolite;
sedative | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| picrotin | | diol;
epoxide;
gamma-lactone;
organic heteropentacyclic compound;
picrotoxane sesquiterpenoid;
tertiary alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| picrotoxinin | | epoxide;
gamma-lactone;
organic heteropentacyclic compound;
picrotoxane sesquiterpenoid;
tertiary alcohol | GABA antagonist;
plant metabolite;
serotonergic antagonist | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| solavetivone | | cyclic ketone;
sesquiterpenoid;
spiro compound | phytoalexin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| thujopsene | | thujopsene | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| agnuside | | benzoate ester;
beta-D-glucoside;
cyclopentapyran;
iridoid monoterpenoid;
monosaccharide derivative;
phenols;
terpene glycoside | anti-inflammatory agent;
cyclooxygenase 2 inhibitor;
plant metabolite;
pro-angiogenic agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dolichodial | | dialdehyde;
iridoid monoterpenoid;
olefinic compound | animal metabolite;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| theasinensin a | | biflavonoid;
gallate ester;
proanthocyanidin | anti-inflammatory agent;
anticoronaviral agent;
apoptosis inducer;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
melanin synthesis inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5,6,7-trimethoxyflavone | | trimethoxyflavone | anti-HSV-1 agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ammodendrine | | acetamides;
N-acylpiperidine;
piperidine alkaloid | plant metabolite;
teratogenic agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| carpaine | | alkaloid;
macrodiolide | cardiovascular drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| myosmine | | pyridine alkaloid;
pyrroline | EC 1.14.14.14 (aromatase) inhibitor;
mutagen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dihydropinosylvin | | diphenylethane;
resorcinols | EC 1.14.18.1 (tyrosinase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gingerol | | beta-hydroxy ketone;
guaiacols | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| mucronulatol | | hydroxyisoflavans;
methoxyisoflavan | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ononin | | 4'-methoxyisoflavones;
7-hydroxyisoflavones 7-O-beta-D-glucoside;
monosaccharide derivative | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| yatein | | benzodioxoles;
butan-4-olide;
lignan;
methoxybenzenes | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| solasodine | | alkaloid antibiotic;
azaspiro compound;
hemiaminal ether;
oxaspiro compound;
sapogenin;
steroid alkaloid | anticonvulsant;
antifungal agent;
antiinfective agent;
antioxidant;
antipyretic;
antispermatogenic agent;
apoptosis inducer;
cardiotonic drug;
central nervous system depressant;
diuretic;
immunomodulator;
plant metabolite;
teratogenic agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1-alpha-terpineol | | alpha-terpineol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 7-deoxyloganic acid | | alpha,beta-unsaturated monocarboxylic acid;
beta-D-glucoside;
cyclopentapyran;
iridoid monoterpenoid;
monosaccharide derivative;
monoterpene glycoside | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| epiafzelechin | | catechin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| maleic acid | | butenedioic acid | algal metabolite;
mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| e-z cinnamic acid | | cinnamic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| farnesol | | farnesol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| resveratrol | | resveratrol | antioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger | 2001 | 2023 | 11.4 | low | 0 | 0 | 0 | 3 | 4 | 2 |
| retinol | | retinol;
vitamin A | human metabolite;
mouse metabolite;
plant metabolite | 1951 | 2023 | 28.5 | low | 4 | 11 | 14 | 10 | 7 | 2 |
| oleic acid | | octadec-9-enoic acid | antioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent | 1947 | 2024 | 24.2 | medium | 57 | 226 | 266 | 258 | 299 | 49 |
| ferulic acid | | ferulic acids | anti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cocaine | | benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid | adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| lycopene | | acyclic carotene | antioxidant;
plant metabolite | 2006 | 2018 | 11.0 | low | 0 | 0 | 0 | 2 | 4 | 0 |
| benzoylecgonine | | benzoate ester;
tropane alkaloid | epitope;
human xenobiotic metabolite;
marine xenobiotic metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| zeatin | | zeatin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gamma-sitosterol | | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols | marine metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| costatolide | | cyclic ether;
delta-lactone;
organic heterotetracyclic compound;
secondary alcohol | HIV-1 reverse transcriptase inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| euscaphic acid | | hydroxy monocarboxylic acid;
pentacyclic triterpenoid;
triol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cinnamtannin b-1 | | proanthocyanidin | cyclooxygenase 2 inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| meso-dihydroguaiaretic acid | | guaiacols;
lignan | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 8-prenylnaringenin | | (2S)-flavan-4-one;
4'-hydroxyflavanones;
trihydroxyflavanone | plant metabolite;
platelet aggregation inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gancaonin I | | 1-benzofurans;
aromatic ether;
resorcinols | antibacterial agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 6,8-diprenylgenistein | | 7-hydroxyisoflavones | antibacterial agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glycyrin | | aromatic ether;
coumarins;
hydroxyisoflavans | antibacterial agent;
metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glyasperin D | | aromatic ether;
hydroxyisoflavans;
methoxyisoflavan | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| licoricidin | | aromatic ether;
hydroxyisoflavans;
methoxyisoflavan | antibacterial agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pallidol | | carbopolycyclic compound;
polyphenol;
stilbenoid | antifungal agent;
antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| egonol | | 1-benzofurans;
aromatic ether;
benzodioxoles;
primary alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 23-hydroxytormentic acid | | hydroxy monocarboxylic acid;
pentacyclic triterpenoid;
tetrol | anti-inflammatory agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| riboflavin | | flavin;
vitamin B2 | anti-inflammatory agent;
antioxidant;
cofactor;
Escherichia coli metabolite;
food colouring;
fundamental metabolite;
human urinary metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite | 1983 | 2015 | 20.3 | low | 0 | 1 | 1 | 2 | 2 | 0 |
| licocoumarone | | 1-benzofurans;
aromatic ether;
resorcinols | antibacterial agent;
apoptosis inducer;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| likviriton | | beta-D-glucoside;
flavanone glycoside;
monohydroxyflavanone;
monosaccharide derivative | anti-inflammatory agent;
anticoronaviral agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sodium benzoate | | organic sodium salt | algal metabolite;
antimicrobial food preservative;
drug allergen;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
human xenobiotic metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3-mercaptohexanol | | alkanethiol;
primary alcohol | flavouring agent;
plant metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3'-methoxyflavone | | 3'-methoxyflavones | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| piperlactam s | | alkaloid;
aromatic ether;
gamma-lactam;
organic heterotetracyclic compound;
phenols | anti-inflammatory agent;
antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| piperyline | | benzodioxoles;
N-acylpyrrolidine;
pyrrolidine alkaloid;
tertiary carboxamide | antifungal agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| crotonic acid | | 2-butenoic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| rhapontin | | rhaponticin | angiogenesis inhibitor;
anti-allergic agent;
anti-inflammatory agent;
antilipemic drug;
antineoplastic agent;
apoptosis inducer;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
hypoglycemic agent;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cinnamaldehyde | | 3-phenylprop-2-enal;
cinnamaldehydes | antifungal agent;
EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor;
flavouring agent;
hypoglycemic agent;
plant metabolite;
sensitiser;
vasodilator agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methyl cinnamate | | methyl cinnamate | antibacterial agent;
fungal metabolite;
nematicide;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| trans-4-coumaric acid | | 4-coumaric acid | food component;
mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2,4-hexadienal | | hexadienal;
polyunsaturated fatty aldehyde;
volatile organic compound | flavouring agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| geraniol | | 3,7-dimethylocta-2,6-dien-1-ol;
monoterpenoid;
primary alcohol | allergen;
fragrance;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| epipinoresinol | | pinoresinol | marine metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sinapinic acid | | sinapic acid | MALDI matrix material;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| citral | | enal;
monoterpenoid;
polyprenal | plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| piperine | | benzodioxoles;
N-acylpiperidine;
piperidine alkaloid;
tertiary carboxamide | food component;
human blood serum metabolite;
NF-kappaB inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| squalene | | triterpene | human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1953 | 2021 | 24.0 | low | 0 | 4 | 2 | 3 | 6 | 2 |
| coumestan | | coumestans;
delta-lactone | phytoestrogen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| antofine | | alkaloid antibiotic;
alkaloid;
aromatic ether;
organic heteropentacyclic compound | angiogenesis inhibitor;
anti-inflammatory agent;
antimicrobial agent;
antineoplastic agent;
antiviral agent;
phytotoxin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| p-hydroxycinnamaldehyde | | cinnamaldehydes | apoptosis inducer;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-methylproline | | L-alpha-amino acid zwitterion;
L-proline derivative;
tertiary amino compound | human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| vedelianin | | cyclic ether;
organic heterotricyclic compound;
resorcinols;
stilbenoid | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pedilstatin | | acetate ester;
phorbol ester;
primary allylic alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| nerol | | 3,7-dimethylocta-2,6-dien-1-ol | fragrance;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cannabidiol | | olefinic compound;
phytocannabinoid;
resorcinols | antimicrobial agent;
plant metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| amygdalin | | amygdalin | antineoplastic agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3,3',4,5'-tetrahydroxystilbene | | catechols;
polyphenol;
resorcinols;
stilbenol | antineoplastic agent;
apoptosis inducer;
geroprotector;
hypoglycemic agent;
plant metabolite;
protein kinase inhibitor;
tyrosine kinase inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dehydrovomifoliol | | dehydrovomifoliol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isoeugenol | | isoeugenol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cotinine | | N-alkylpyrrolidine;
pyridines;
pyrrolidin-2-ones;
pyrrolidine alkaloid | antidepressant;
biomarker;
human xenobiotic metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| huperzine a | | organic heterotricyclic compound;
primary amino compound;
pyridone;
sesquiterpene alkaloid | EC 3.1.1.7 (acetylcholinesterase) inhibitor;
neuroprotective agent;
nootropic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| nootkatone | | carbobicyclic compound;
enone;
sesquiterpenoid | fragrance;
insect repellent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| geranyl acetate | | acetate ester;
monoterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| coniferyl alcohol | | guaiacols;
phenylpropanoid | animal metabolite;
monolignol;
mouse metabolite;
pheromone;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| geranylacetone | | monoterpene ketone | flavouring agent;
fragrance;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| aurapten | | coumarins;
monoterpenoid | antihypertensive agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
dopaminergic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
gamma-secretase modulator;
gastrointestinal drug;
hepatoprotective agent;
matrix metalloproteinase inhibitor;
neuroprotective agent;
plant metabolite;
PPARalpha agonist;
vulnerary | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| chlorogenic acid | | cinnamate ester;
tannin | food component;
plant metabolite | 1984 | 2023 | 16.0 | low | 0 | 1 | 0 | 1 | 0 | 2 |
| goitrin | | 5-ethenyl-1,3-oxazolidine-2-thione | antiviral agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 7-deacetylgedunin | | cyclic terpene ketone;
delta-lactone;
enone;
epoxide;
furans;
limonoid;
pentacyclic triterpenoid | anti-inflammatory agent;
antimalarial;
metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| manool | | labdane diterpenoid;
tertiary alcohol | antibacterial agent;
antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-oxindole-3-acetic acid | | indole-3-acetic acids;
monocarboxylic acid;
oxindoles | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| bigelovin | | acetate ester;
cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
sesquiterpene lactone | antineoplastic agent;
apoptosis inducer;
immunomodulator;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cyclanoline | | berberine alkaloid;
quaternary ammonium ion | EC 3.1.1.7 (acetylcholinesterase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sideroxylin | | dihydroxyflavone;
monomethoxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ladanein | | dihydroxyflavone;
dimethoxyflavone | antiviral agent;
plant metabolite;
radical scavenger | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| t-muurolol | | cadinane sesquiterpenoid;
carbobicyclic compound;
octahydronaphthalenes;
tertiary alcohol | bacterial metabolite;
fungicide;
marine metabolite;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| alpha-carotene | | carotenoid beta-end derivative;
cyclic carotene | plant metabolite;
provitamin A | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| citramalate | | dicarboxylic acid dianion | human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| fraxin | | aromatic ether;
beta-D-glucoside;
hydroxycoumarin | anti-inflammatory agent;
hepatoprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| decaprenoic acid | | alpha,beta-unsaturated monocarboxylic acid;
methyl-branched fatty acid;
monoterpenoid;
polyunsaturated fatty acid | antifungal agent;
EC 1.14.18.1 (tyrosinase) inhibitor;
melanin synthesis inhibitor;
pheromone;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gallocatechin-3-gallate | | catechin;
gallate ester;
polyphenol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| quercetin | | 7-hydroxyflavonol;
pentahydroxyflavone | antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger | 1995 | 2023 | 13.5 | low | 0 | 0 | 1 | 8 | 5 | 3 |
| coniferin | | aromatic ether;
cinnamyl alcohol beta-D-glucoside;
monosaccharide derivative | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| biochanin a | | 4'-methoxyisoflavones;
7-hydroxyisoflavones | antineoplastic agent;
EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| formononetin | | 4'-methoxyisoflavones;
7-hydroxyisoflavones | phytoestrogen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gibberellin a1 | | C19-gibberellin;
gibberellin monocarboxylic acid;
lactone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| leukotriene a4 | | epoxy fatty acid;
leukotriene;
long-chain fatty acid;
oxylipin;
polyunsaturated fatty acid | human metabolite;
mouse metabolite;
plant metabolite | 2009 | 2022 | 8.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| sinapine | | acylcholine | antioxidant;
photosynthetic electron-transport chain inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| trans-phytol | | diterpenoid;
long-chain primary fatty alcohol | algal metabolite;
plant metabolite;
schistosomicide drug | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| vitexin | | C-glycosyl compound;
trihydroxyflavone | antineoplastic agent;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
plant metabolite;
platelet aggregation inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| acacetin | | dihydroxyflavone;
monomethoxyflavone | anticonvulsant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| luteolin | | 3'-hydroxyflavonoid;
tetrahydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| quercitrin | | alpha-L-rhamnoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone | antileishmanial agent;
antioxidant;
EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| scopoletin | | hydroxycoumarin | plant growth regulator;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| beta carotene | | carotenoid beta-end derivative;
cyclic carotene | antioxidant;
biological pigment;
cofactor;
ferroptosis inhibitor;
human metabolite;
mouse metabolite;
plant metabolite;
provitamin A | 1987 | 2023 | 14.9 | low | 2 | 1 | 10 | 56 | 49 | 7 |
| leukotriene b4 | | dihydroxy monocarboxylic acid;
hydroxy polyunsaturated fatty acid;
leukotriene;
long-chain fatty acid | human metabolite;
mouse metabolite;
plant metabolite;
vasoconstrictor agent | 1985 | 2014 | 30.0 | low | 3 | 9 | 14 | 7 | 1 | 0 |
| coniferaldehyde | | cinnamaldehydes;
guaiacols;
phenylpropanoid | antifungal agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| herbacetin | | 7-hydroxyflavonol;
pentahydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antilipemic drug;
antineoplastic agent;
apoptosis inducer;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5'-o-caffeoylquinic acid | | cinnamate ester;
cyclitol carboxylic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| luteolin-7-glucoside | | beta-D-glucoside;
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone | antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gossypetin | | 7-hydroxyflavonol;
hexahydroxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ayanin | | dihydroxyflavone;
trimethoxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| apiin | | beta-D-glucoside;
dihydroxyflavone;
glycosyloxyflavone | EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| (all-e) phytoene | | phytoene | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| vitamin d 2 | | hydroxy seco-steroid;
seco-ergostane;
vitamin D | bone density conservation agent;
nutraceutical;
plant metabolite;
rodenticide | 1963 | 1964 | 60.8 | low | 0 | 5 | 0 | 0 | 0 | 0 |
| stigmasterol | | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols;
stigmastane sterol | plant metabolite | 2002 | 2020 | 11.0 | low | 0 | 0 | 0 | 2 | 5 | 0 |
| sinapaldehyde | | cinnamaldehydes;
dimethoxybenzene;
phenols | antifungal agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| quercetin 3-o-glucopyranoside | | beta-D-glucoside;
monosaccharide derivative;
quercetin O-glucoside;
tetrahydroxyflavone | antineoplastic agent;
antioxidant;
antipruritic drug;
bone density conservation agent;
geroprotector;
histamine antagonist;
osteogenesis regulator;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3-methylkaempferol | | monomethoxyflavone;
trihydroxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| kaempferol | | 7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone | antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| abscisic acid | | 2-cis-abscisic acid | plant hormone;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| senecionine | | lactone;
pyrrolizidine alkaloid;
tertiary alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gamma-linolenic acid | | linolenic acid;
omega-6 fatty acid | human metabolite;
mouse metabolite;
plant metabolite | 1965 | 2023 | 25.9 | medium | 15 | 32 | 47 | 23 | 19 | 4 |
| genistein | | 7-hydroxyisoflavones | antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor | 2001 | 2018 | 15.8 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| petroselinic acid | | octadec-6-enoic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cyclobenzaprine | | 9,11,13-octadecatrienoic acid | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| jasmonic acid | | oxo monocarboxylic acid | jasmonates;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-hexenal, z-isomer | | 2-hexenal | antibacterial agent;
flavouring agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| aureusidin | | hydroxyaurone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| butein | | chalcones;
polyphenol | antineoplastic agent;
antioxidant;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
geroprotector;
hypoglycemic agent;
plant metabolite;
radiosensitizing agent;
tyrosine kinase inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| antheraxanthin | | epoxycarotenol | biological pigment;
marine metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| astaxanthine | | carotenol;
carotenone | animal metabolite;
anticoagulant;
antioxidant;
food colouring;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| capsanthin | | carotenone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gardenia yellow | | diester;
disaccharide derivative;
diterpenoid | antioxidant;
food colouring;
histological dye;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cryptoxanthins | | carotenol | antioxidant;
biomarker;
plant metabolite;
provitamin A | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| lutein | | carotenol | food colouring;
plant metabolite | 1993 | 2018 | 19.3 | low | 0 | 0 | 2 | 3 | 1 | 0 |
| hispidol | | hydroxyaurone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isobutrin | | beta-D-glucoside;
chalcones;
monosaccharide derivative;
phenols | anti-inflammatory agent;
hepatoprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cassaine | | enoate ester;
organic hydroxy compound;
tertiary amino compound;
tricyclic diterpenoid | antihypertensive agent;
cardiotonic drug;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
local anaesthetic;
plant metabolite;
poison | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| okanin | | benzenetriol;
chalcones | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cucurbitacin i | | cucurbitacin;
tertiary alpha-hydroxy ketone | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| brassicasterol | | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols | algal metabolite;
animal metabolite;
biomarker;
EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor;
human metabolite;
marine metabolite;
plant metabolite;
sterol biosynthesis inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| harman | | harmala alkaloid;
indole alkaloid fundamental parent;
indole alkaloid | anti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| esculetin | | hydroxycoumarin | antioxidant;
plant metabolite;
ultraviolet filter | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 7-hydroxycoumarin | | hydroxycoumarin | fluorescent probe;
food component;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| eupatolide | | gamma-lactone;
germacranolide;
homoallylic alcohol;
secondary alcohol | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| petasin | | alicyclic ketone;
enoate ester;
enone;
sesquiterpenoid | anti-allergic agent;
EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} activator;
plant metabolite;
vasodilator agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| oleuropein | | beta-D-glucoside;
catechols;
diester;
methyl ester;
pyrans;
secoiridoid glycoside | anti-inflammatory agent;
antihypertensive agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
NF-kappaB inhibitor;
nutraceutical;
plant metabolite;
radical scavenger | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| amentoflavone | | biflavonoid;
hydroxyflavone;
ring assembly | angiogenesis inhibitor;
antiviral agent;
cathepsin B inhibitor;
P450 inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| apigenin dimethylether | | dimethoxyflavone;
monohydroxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| axillarin | | dimethoxyflavone;
tetrahydroxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| azaleatin | | 7-hydroxyflavonol;
monomethoxyflavone;
tetrahydroxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| baicalein | | trihydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hormone antagonist;
plant metabolite;
prostaglandin antagonist;
radical scavenger | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| chrysin | | 7-hydroxyflavonol;
dihydroxyflavone | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
hepatoprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| chrysosplenetin b | | dihydroxyflavone;
tetramethoxyflavone | antiviral agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| diosmetin | | 3'-hydroxyflavonoid;
monomethoxyflavone;
trihydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
bone density conservation agent;
cardioprotective agent;
plant metabolite;
tropomyosin-related kinase B receptor agonist;
vasodilator agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| fisetin | | 3'-hydroxyflavonoid;
7-hydroxyflavonol;
tetrahydroxyflavone | anti-inflammatory agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| galangin | | 7-hydroxyflavonol;
trihydroxyflavone | antimicrobial agent;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gossypin | | 7-hydroxyflavonol;
glycosyloxyflavone;
monosaccharide derivative;
pentahydroxyflavone | neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| hispidulin | | monomethoxyflavone;
trihydroxyflavone | anti-inflammatory agent;
anticonvulsant;
antineoplastic agent;
antioxidant;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| euxanthone | | phenols;
xanthones | metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gartanin | | polyphenol;
xanthones | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gentiacaulein | | aromatic ether;
polyphenol;
xanthones | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gentisein | | polyphenol;
xanthones | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gentisin | | aromatic ether;
polyphenol;
xanthones | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isogentisin | | aromatic ether;
polyphenol;
xanthones | EC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| hyperoside | | beta-D-galactoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone | hepatoprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| mangiferin | | C-glycosyl compound;
xanthones | anti-inflammatory agent;
antioxidant;
hypoglycemic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| mangostin | | aromatic ether;
phenols;
xanthones | antimicrobial agent;
antineoplastic agent;
antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1,8-dihydroxy-3,7-dimethoxyxanthone | | aromatic ether;
polyphenol;
xanthones | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| norathyriol | | polyphenol;
xanthones | antineoplastic agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1,2,8-trihydroxy-6-methoxyxanthone | | aromatic ether;
polyphenol;
xanthones | antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| kuwanon g | | resorcinols;
tetrahydroxyflavone | anti-inflammatory agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| kuwanon h | | resorcinols;
tetrahydroxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| morusin | | extended flavonoid;
trihydroxyflavone | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| myricetin | | 7-hydroxyflavonol;
hexahydroxyflavone | antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| myricitrin | | alpha-L-rhamnoside;
glycosyloxyflavone;
monosaccharide derivative;
pentahydroxyflavone | anti-allergic agent;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pachypodol | | dihydroxyflavone;
trimethoxyflavone | antiemetic;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| quercetagetin | | flavonols;
hexahydroxyflavone | antioxidant;
antiviral agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| robinetin | | 7-hydroxyflavonol;
pentahydroxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| robinin | | dihydroxyflavone;
glycosyloxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| santin | | dihydroxyflavone;
trimethoxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| wogonin | | dihydroxyflavone;
monomethoxyflavone | angiogenesis inhibitor;
antineoplastic agent;
cyclooxygenase 2 inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 7-hydroxy-6,4'-dimethoxyisoflavone | | 4'-methoxyisoflavones;
7-hydroxyisoflavones | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| coumestrol | | coumestans;
delta-lactone;
polyphenol | anti-inflammatory agent;
antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| daidzein | | 7-hydroxyisoflavones | antineoplastic agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
phytoestrogen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pterostilbene | | diether;
methoxybenzenes;
stilbenol | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
hypoglycemic agent;
neuroprotective agent;
neurotransmitter;
plant metabolite;
radical scavenger | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| genistein-8-c-glucoside | | 7-hydroxyisoflavones;
C-glycosyl compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5-o-caffeoylshikimic acid | | alpha,beta-unsaturated monocarboxylic acid;
carboxylic ester;
catechols;
cyclohexenecarboxylic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cynarine | | alkyl caffeate ester;
quinic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| iridin | | 4'-methoxyisoflavones;
7-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
monosaccharide derivative | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| rosmarinic acid | | rosmarinic acid | geroprotector;
plant metabolite | 2008 | 2015 | 13.0 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| acteoside | | catechols;
cinnamate ester;
disaccharide derivative;
glycoside;
polyphenol | anti-inflammatory agent;
antibacterial agent;
antileishmanial agent;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| orobol | | 7-hydroxyisoflavones | anti-inflammatory agent;
fungal metabolite;
plant metabolite;
radical scavenger | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| psi-baptigenin | | 7-hydroxyisoflavones;
benzodioxoles | antiprotozoal drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| psoralidin | | coumestans;
delta-lactone;
polyphenol | estrogen receptor agonist;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| puerarin | | C-glycosyl compound;
hydroxyisoflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tectoridin | | 7-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
methoxyisoflavone;
monosaccharide derivative | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tectorigenin | | 7-hydroxyisoflavones;
methoxyisoflavone | anti-inflammatory agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| wighteone | | 7-hydroxyisoflavones | antifungal agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| maytansine | | alpha-amino acid ester;
carbamate ester;
epoxide;
maytansinoid;
organic heterotetracyclic compound;
organochlorine compound | antimicrobial agent;
antimitotic;
antineoplastic agent;
plant metabolite;
tubulin modulator | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ellagic acid | | catechols;
cyclic ketone;
lactone;
organic heterotetracyclic compound;
polyphenol | antioxidant;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor;
EC 2.4.1.1 (glycogen phosphorylase) inhibitor;
EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor;
EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor;
EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
food additive;
fungal metabolite;
geroprotector;
plant metabolite;
skin lightening agent | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| savinin | | benzodioxoles;
gamma-lactone;
lignan | anti-inflammatory agent;
anticoronaviral agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
plant metabolite;
T-cell proliferation inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tectochrysin | | monohydroxyflavone;
monomethoxyflavone | antidiarrhoeal drug;
antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2'-hydroxygenistein | | hydroxyisoflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| astragalin | | beta-D-glucoside;
kaempferol O-glucoside;
monosaccharide derivative;
trihydroxyflavone | plant metabolite;
trypanocidal drug | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cinnamyl acetate | | acetate ester | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| kaempferol-3-o-galactoside | | beta-D-galactoside;
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone | antifungal agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| vitexin rhamnoside | | C-glycosyl compound;
disaccharide derivative;
trihydroxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| kaempferol 3-o-sophoroside | | sophoroside;
trihydroxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| quercetin-3-o-sophoroside | | sophoroside;
tetrahydroxyflavone | antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ethyl linoleate | | long-chain fatty acid ethyl ester | anti-inflammatory agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| plaunotol | | diterpenoid;
primary alcohol | anti-ulcer drug;
antibacterial agent;
antineoplastic agent;
apoptosis inducer;
nephroprotective agent;
plant metabolite;
vulnerary | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| sofalcone | | aromatic ether;
chalcones;
monocarboxylic acid | anti-ulcer drug;
antibacterial agent;
gastrointestinal drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| xanthoxin | | apo carotenoid sesquiterpenoid;
enal | plant growth retardant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tocotrienol, alpha | | tocotrienol;
vitamin E | ferroptosis inhibitor;
human metabolite;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tocotrienol, beta | | tocotrienol;
vitamin E | antineoplastic agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gamma-tocotrienol | | tocotrienol;
vitamin E | antineoplastic agent;
antioxidant;
apoptosis inducer;
hepatoprotective agent;
plant metabolite;
radiation protective agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tocotrienol, delta | | tocotrienol;
vitamin E | anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
bone density conservation agent;
NF-kappaB inhibitor;
plant metabolite;
radiation protective agent;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-hydroxychalcone | | chalcones;
phenols | antihypertensive agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 9-hydroxy-10,12-octadecadienoic acid | | HODE;
octadecadienoic acid | human metabolite;
metabolite;
mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-heptenal | | enal;
medium-chain fatty aldehyde;
monounsaturated fatty aldehyde | plant metabolite;
uremic toxin | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-nonenal, (trans)-isomer | | enal;
medium-chain fatty aldehyde;
monounsaturated fatty aldehyde | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| oleylamide | | primary fatty amide | human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1-monooleoyl-rac-glycerol | | 1-acylglycerol 18:1;
monooleoylglycerol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| monolinolein | | 1-acylglycerol 18:2;
rac-1-monoacylglycerol | antiviral agent;
human metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methyl linoleate | | fatty acid methyl ester | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| vitamin k 1 | | phylloquinones;
vitamin K | cofactor;
human metabolite;
plant metabolite | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| morphine | | morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound | anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic | 1999 | 2004 | 22.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| delta(3)-hexadecenoic acid | | hexadecenoic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| stearidonic acid | | long-chain fatty acid;
octadecatetraenoic acid;
omega-3 fatty acid | Daphnia galeata metabolite;
mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| juniperonic acid | | icosatetraenoic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| casticin | | dihydroxyflavone;
tetramethoxyflavone | apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| rosmarinic acid | | carboxylic ester;
monocarboxylic acid;
phenylpropanoid;
polyphenol | antioxidant;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug;
plant metabolite;
serine proteinase inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cannabigerol | | phytocannabinoid;
resorcinols | anti-inflammatory agent;
antibacterial agent;
antioxidant;
appetite enhancer;
cannabinoid receptor agonist;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| centaureidin | | trihydroxyflavone;
trimethoxyflavone | antineoplastic agent;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cinnamyl alcohol | | cinnamyl alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 7-demethylsuberosin | | hydroxycoumarin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| kaempferol 3-o-rhamnoside | | glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone | anti-inflammatory agent;
antibacterial agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| syringin | | beta-D-glucoside;
dimethoxybenzene;
monosaccharide derivative;
primary alcohol | hepatoprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3,3'-di-o-methylquercetin | | 3'-methoxyflavones;
dimethoxyflavone;
trihydroxyflavone | antibacterial agent;
antineoplastic agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glycitein | | 7-hydroxyisoflavone;
methoxyisoflavone | fungal metabolite;
phytoestrogen;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glycycoumarin | | aromatic ether;
coumarins;
resorcinols | antispasmodic drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| quadrangularin a | | indanes;
polyphenol;
stilbenoid | antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isoginkgetin | | aromatic ether;
biflavonoid | antineoplastic agent;
EC 3.4.24.35 (gelatinase B) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isomangiferin | | C-glycosyl compound;
polyphenol;
xanthones | anti-HSV-1 agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isosalipurposide | | beta-D-glucoside;
chalcones;
monosaccharide derivative;
resorcinols | antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| kaempferol-3-o-rutinoside | | disaccharide derivative;
kaempferol O-glucoside;
rutinoside;
trihydroxyflavone | metabolite;
plant metabolite;
radical scavenger | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| luteolin 4'-o-glucoside | | beta-D-glucoside;
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methyl linolenate | | fatty acid methyl ester | insect attractant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3'-o-methylorobol | | hydroxyisoflavone;
methoxyisoflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1,3,6-trihydroxy-2-methyl-9,10-anthraquinone | | trihydroxyanthraquinone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cudraflavone c | | tetrahydroxyflavone | antibacterial agent;
antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| muromonab-cd3 | | extended flavonoid;
pyranochromane;
trihydroxyflavone | anti-inflammatory agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| neobavaisoflavone | | 7-hydroxyisoflavones | antineoplastic agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
plant metabolite;
platelet aggregation inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| neoglycyrol | | aromatic ether;
coumestans;
delta-lactone;
polyphenol | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| beta-ocimene | | beta-ocimene | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ombuine | | dimethoxyflavone;
flavonols;
trihydroxyflavone | anti-inflammatory agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| osthenol | | hydroxycoumarin | antifungal agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5,7-dihydroxy-4',6-dimethoxyflavone | | dihydroxyflavone;
dimethoxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tiliroside | | cinnamate ester;
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| spiraeoside | | beta-D-glucoside;
flavonols;
monosaccharide derivative;
quercetin O-glucoside;
tetrahydroxyflavone | antineoplastic agent;
antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| rhamnazin | | aromatic ether;
dimethoxyflavone;
phenols;
trihydroxyflavone | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| kaempferol-7-methyl ether | | flavonols;
monomethoxyflavone;
trihydroxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| oridonin | | cyclic hemiketal;
enone;
ent-kaurane diterpenoid;
organic heteropentacyclic compound;
secondary alcohol | angiogenesis inhibitor;
anti-asthmatic agent;
antibacterial agent;
antineoplastic agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 7,8-dimethylalloxazine | | 7,8-dimethylbenzo[g]pteridine-2,4-dione | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ergothioneine | | 1,3-dihydroimidazole-2-thiones;
amino-acid betaine;
L-histidine derivative;
sulfur-containing amino acid | antioxidant;
chelator;
fungal metabolite;
plant metabolite;
xenobiotic metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ermanin | | dihydroxyflavone;
dimethoxyflavone | anti-inflammatory agent;
antimycobacterial drug;
antineoplastic agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5-hydroxy-3,3',4',7-tetramethoxyflavone | | 3'-methoxyflavones;
monohydroxyflavone;
tetramethoxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methyl 2,5-dihydroxycinnamate | | cinnamate ester;
hydroquinones;
methyl ester | EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
geroprotector;
human urinary metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methyl ferulate | | cinnamate ester;
guaiacols;
methyl ester | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| lichexanthone | | aromatic ether;
phenols;
xanthones | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glyceryl behenate | | 1-monoglyceride;
fatty acid ester | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ethyl oleate | | long-chain fatty acid ethyl ester | acaricide;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2-pentenal | | 2-pentenal | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| erucyl amide | | 13-docosenamide | EC 3.1.1.7 (acetylcholinesterase) inhibitor;
human metabolite;
mammalian metabolite;
plant metabolite;
rat metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| beta-damascenone | | apo carotenoid monoterpenoid;
cyclic monoterpene ketone;
enone | fragrance;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| piperic acid | | alpha,beta-unsaturated monocarboxylic acid;
benzodioxoles | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pipercallosidine | | alkaloid;
benzodioxoles;
enamide;
secondary carboxamide | apoptosis inducer;
metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dehydrodiconiferyl alcohol | | 1-benzofurans;
guaiacols;
guaiacyl lignin;
primary alcohol | anti-inflammatory agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| noreugenin | | chromones;
resorcinols | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| decussatin | | aromatic ether;
phenols;
xanthones | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ecdysterone | | 14alpha-hydroxy steroid;
20-hydroxy steroid;
22-hydroxy steroid;
25-hydroxy steroid;
2beta-hydroxy steroid;
3beta-sterol;
ecdysteroid;
phytoecdysteroid | animal metabolite;
plant metabolite | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| beta-aminopropionitrile fumarate (2:1) | | fumarate salt | antineoplastic agent;
antirheumatic drug;
collagen cross-linking inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gamma-mangostin | | phenols;
xanthones | antineoplastic agent;
plant metabolite;
protein kinase inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| irigenin | | 4'-methoxyisoflavones;
hydroxyisoflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5,4'-dihydroxy-7,3'-dimethoxyflavone | | dihydroxyflavone;
dimethoxyflavone | anti-allergic agent;
anti-inflammatory agent;
antibacterial agent;
antioxidant;
melanin synthesis inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1,7-dihydroxy-4-methoxyxanthone | | aromatic ether;
phenols;
xanthones | metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tetrahydroxycurcumin | | beta-diketone;
catechols;
diarylheptanoid;
enone;
polyphenol | anti-inflammatory agent;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| zerumbone | | cyclic ketone;
sesquiterpenoid | anti-inflammatory agent;
glioma-associated oncogene inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| solanesol | | nonaprenol;
primary alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| semilicoisoflavone b | | 7-hydroxyisoflavones | EC 1.1.1.21 (aldehyde reductase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| lespenefril | | alpha-L-rhamnoside;
dihydroxyflavone;
glycosyloxyflavone;
monosaccharide derivative;
polyphenol | anti-inflammatory agent;
antidepressant;
antineoplastic agent;
apoptosis inducer;
bone density conservation agent;
hypoglycemic agent;
immunomodulator;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| quercetin 3-sambubioside | | disaccharide derivative;
quercetin O-glucoside;
tetrahydroxyflavone | antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| baohuoside i | | glycosyloxyflavone | anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| avicularin | | alpha-L-arabinofuranoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone | hepatoprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ochnaflavone | | aromatic ether;
biflavonoid;
hydroxyflavone | anti-inflammatory agent;
antiatherogenic agent;
antibacterial agent;
EC 3.1.1.4 (phospholipase A2) inhibitor;
leukotriene antagonist;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isowighteone | | 7-hydroxyisoflavones | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| triolein | | triglyceride | Caenorhabditis elegans metabolite;
plant metabolite | 1964 | 2021 | 26.1 | low | 0 | 3 | 3 | 3 | 4 | 1 |
| resiniferatoxin | | carboxylic ester;
diterpenoid;
enone;
monomethoxybenzene;
organic heteropentacyclic compound;
ortho ester;
phenols;
tertiary alpha-hydroxy ketone | analgesic;
neurotoxin;
plant metabolite;
TRPV1 agonist | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| lyoniside | | beta-D-glucoside;
monosaccharide derivative;
steroid saponin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-hydroxycordoin | | aromatic ether;
chalcones;
polyphenol | anti-inflammatory agent;
antibacterial agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-feruloylserotonin | | aromatic ether;
cinnamamides;
hydroxyindoles;
phenols;
secondary carboxamide | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| zosteric acid | | aryl sulfate;
cinnamic acids | antifouling biocide;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| eupomatenoid 6 | | benzofurans;
phenols | anti-inflammatory agent;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
NF-kappaB inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| amaranthin betacyanin | | disaccharide derivative;
indoles;
olefinic compound;
tetrahydropyridine | biological pigment;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| mevalonolactone | | 4-hydroxy-4-methyloxan-2-one | fungal metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| coronardine | | alkaloid ester;
methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound | antileishmanial agent;
antineoplastic agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| columbianadin | | alpha,beta-unsaturated carboxylic ester;
furanocoumarin | anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
hepatoprotective agent;
plant metabolite;
rat metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| germacrone | | germacrane sesquiterpenoid;
olefinic compound | androgen antagonist;
anti-inflammatory agent;
antifeedant;
antifungal agent;
antimicrobial agent;
antineoplastic agent;
antioxidant;
antitussive;
antiviral agent;
apoptosis inducer;
autophagy inducer;
hepatoprotective agent;
insecticide;
neuroprotective agent;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| salannin | | acetate ester;
furans;
limonoid;
methyl ester;
organic heteropentacyclic compound | antifeedant;
insect growth regulator;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| thunberginol f | | catechols;
gamma-lactone;
isobenzofuranone | metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 9-hydroxy-10,12,15-octadecatrienoic acid | | 9-HOTrE | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| valerenic acid | | carbobicyclic compound;
monocarboxylic acid;
sesquiterpenoid | GABA modulator;
plant metabolite;
sedative;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| zeatin riboside | | 9-ribosylzeatin;
nucleoside analogue | cytokinin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| acuminatin | | 1-benzofurans;
dimethoxybenzene;
neolignan;
olefinic compound;
ring assembly | fungal metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cucurbitacin I 2-O-beta-D-glucopyranoside | | beta-D-glucoside;
cucurbitacin;
monosaccharide derivative;
tertiary alpha-hydroxy ketone;
triterpenoid saponin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| perflubron | | 2-acyl-4-prenylphloroglucinol;
chalcones | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tuberonic acid | | cyclopentanones;
homoallylic alcohol;
oxo monocarboxylic acid;
primary alcohol | jasmonates;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| salvianolic acid B | | 1-benzofurans;
catechols;
dicarboxylic acid;
enoate ester;
polyphenol | anti-inflammatory agent;
antidepressant;
antineoplastic agent;
antioxidant;
apoptosis inducer;
autophagy inhibitor;
cardioprotective agent;
hepatoprotective agent;
hypoglycemic agent;
neuroprotective agent;
osteogenesis regulator;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| trilobatin | | aryl beta-D-glucoside;
dihydrochalcones;
monosaccharide derivative | anti-inflammatory agent;
antioxidant;
plant metabolite;
sweetening agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2',4',6'-trihydroxychalcone | | chalcones | antifungal agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| beta-tocopherol | | tocopherol;
vitamin E | food component;
plant metabolite | 2009 | 2016 | 12.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| nyasol | | 1,3-bis(p-hydroxyphenyl)pentane-1,4-diene | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ginsenoside rb2 | | 12beta-hydroxy steroid;
beta-D-glucoside;
disaccharide derivative;
ginsenoside;
tetracyclic triterpenoid | antiviral agent;
hypoglycemic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| yunaconitine | | acetate ester;
aromatic ether;
benzoate ester;
bridged compound;
diterpene alkaloid;
organic heteropolycyclic compound;
polyether;
secondary alcohol;
tertiary alcohol;
tertiary amino compound | antifeedant;
human urinary metabolite;
phytotoxin;
plant metabolite;
xenobiotic | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3-tyrosine | | hydroxyphenylalanine;
L-alpha-amino acid zwitterion;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
phenols | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| alpha-solanine | | glycoalkaloid;
organic heterohexacyclic compound;
steroid saponin;
trisaccharide derivative | antineoplastic agent;
apoptosis inducer;
phytotoxin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3-O-feruloyl-D-quinic acid | | enoate ester;
quinic acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ginsenoside f1 | | 12beta-hydroxy steroid;
3beta-hydroxy-4,4-dimethylsteroid;
3beta-hydroxy steroid;
6alpha-hydroxy steroid;
beta-D-glucoside;
ginsenoside;
tetracyclic triterpenoid | apoptosis inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| capsiate | | carboxylic ester;
monomethoxybenzene;
phenols | angiogenesis inhibitor;
anti-allergic agent;
anti-inflammatory agent;
antioxidant;
capsaicin receptor agonist;
hypoglycemic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| p-coumaric acid glucoside | | 4-O-beta-D-glucosyl-4-coumaric acid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ginsenoside m1 | | 12beta-hydroxy steroid;
3beta-hydroxy-4,4-dimethylsteroid;
3beta-hydroxy steroid;
beta-D-glucoside;
ginsenoside;
tetracyclic triterpenoid | anti-allergic agent;
anti-inflammatory agent;
antineoplastic agent;
hepatoprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| nicotianamine | | amino acid zwitterion;
nicotianamine | chelator;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ginsenoside rb1 | | ginsenoside;
glycoside;
tetracyclic triterpenoid | anti-inflammatory drug;
anti-obesity agent;
apoptosis inhibitor;
neuroprotective agent;
plant metabolite;
radical scavenger | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 6''-o-malonyldaidzin | | glycosyloxyisoflavone;
hydroxyisoflavone;
malonate ester;
monosaccharide derivative | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ginsenoside f2 | | 12beta-hydroxy steroid;
beta-D-glucoside;
ginsenoside;
tetracyclic triterpenoid | antineoplastic agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ginsenoside rg3 | | ginsenoside;
glycoside;
tetracyclic triterpenoid | angiogenesis modulating agent;
antineoplastic agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 4alpha-methylergosta-8,24(28)-dien-3,7,11-trione-26-oic acid | | 11-oxo steroid;
3-oxo steroid;
7-oxo steroid;
ergostanoid;
monocarboxylic acid;
steroid acid | anti-inflammatory agent;
antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| hetacillin | | guaiacols;
lignan;
oxolanes;
polyphenol;
tetrol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| kaempferol 7-o-glucoside | | beta-D-glucoside;
flavonols;
kaempferol O-glucoside;
monosaccharide derivative;
trihydroxyflavone | metabolite;
plant metabolite;
radical scavenger | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3-epi-fagomine | | amino monosaccharide;
hydroxypiperidine;
primary alcohol;
secondary alcohol;
secondary amino compound;
triol | EC 3.2.1.10 (oligo-1,6-glucosidase) inhibitor;
EC 3.2.1.23 (beta-galactosidase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| akuammicine | | methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound;
tertiary amino compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| demethylzeylasteral | | arenecarbaldehyde;
benzenediols;
carbopolycyclic compound;
cyclic ketone;
enone;
oxo monocarboxylic acid | anti-inflammatory agent;
EC 2.4.1.17 (glucuronosyltransferase) inhibitor;
immunosuppressive agent;
nephroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| alpha-cadinol | | cadinane sesquiterpenoid;
carbobicyclic compound;
octahydronaphthalenes;
tertiary alcohol | fungicide;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 11-hydroxysugiol | | abietane diterpenoid;
carbotricyclic compound;
catechols;
cyclic terpene ketone;
meroterpenoid | EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| triptohypol C | | benzenediols;
monocarboxylic acid;
pentacyclic triterpenoid | apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| trilobacin | | butenolide;
polyketide;
triol | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone | | chalcones;
monomethoxybenzene;
resorcinols | EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one | | diarylheptanoid;
enone;
phenols | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 6-deacetylnimbin | | cyclic terpene ketone;
diester;
enone;
furans;
limonoid;
methyl ester;
tetracyclic triterpenoid | antifeedant;
insect growth regulator;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1,7-bis(4-hydroxyphenyl)hepta-4E-6E-dien-3-one | | diarylheptanoid;
enone;
phenols | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2,3-dihydro-3beta-methoxy withaferin A | | 27-hydroxy steroid;
4-hydroxy steroid;
delta-lactone;
epoxy steroid;
ergostanoid;
primary alcohol;
secondary alcohol;
withanolide | metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| azadirone | | acetate ester;
cyclic terpene ketone;
furans;
limonoid;
tetracyclic triterpenoid | antineoplastic agent;
antiplasmodial drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dihydroartemisinic acid | | carbobicyclic compound;
monocarboxylic acid;
octahydronaphthalenes;
sesquiterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| atractyligenine | | carbotetracyclic compound;
dihydroxy monocarboxylic acid;
ent-kaurane diterpenoid;
tetracyclic diterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dihydrogenistin | | beta-D-glucoside;
hydroxyisoflavanone;
monosaccharide derivative | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-benzylhexadecanamide | | macamide;
secondary carboxamide | EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| triphosphate | | aldehyde;
indole alkaloid;
organic heteropentacyclic compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| aspalathin | | C-glycosyl compound;
catechols;
dihydrochalcones;
polyketide;
polyphenol | antioxidant;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
hypoglycemic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glyceryl ferulate | | 1-monoglyceride;
aromatic ether;
enoate ester;
phenols | antioxidant;
plant metabolite;
ultraviolet filter | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| obolactone | | 2-pyranones;
4-pyranones | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| quinine | | Aspidosperma alkaloid;
epoxide;
methyl ester;
monoterpenoid indole alkaloid;
organic heterohexacyclic compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| alpha-onocerin | | diol;
olefinic compound;
secondary alcohol;
triterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| kalopanax saponin b | | carboxylic ester;
pentacyclic triterpenoid;
triterpenoid saponin | anti-inflammatory agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ginsenoside rd | | beta-D-glucoside;
ginsenoside;
tetracyclic triterpenoid | anti-inflammatory drug;
apoptosis inducer;
immunosuppressive agent;
neuroprotective agent;
plant metabolite;
vulnerary | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| (+)-dehydrodiconiferyl alcohol | | dehydrodiconiferyl alcohol | antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| viridiflorol | | carbotricyclic compound;
sesquiterpenoid;
tertiary alcohol | anti-inflammatory agent;
antifeedant;
antimycobacterial drug;
plant metabolite;
volatile oil component | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gedunin | | acetate ester;
enone;
epoxide;
furans;
lactone;
limonoid;
organic heteropentacyclic compound;
pentacyclic triterpenoid | antimalarial;
antineoplastic agent;
Hsp90 inhibitor;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| morelloflavone | | biflavonoid;
hydroxyflavanone;
hydroxyflavone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid | | dihydroxy monocarboxylic acid;
pentacyclic triterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| azadiradione | | acetate ester;
cyclic terpene ketone;
furans;
limonoid;
tetracyclic triterpenoid | anti-inflammatory agent;
antimycobacterial drug;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| (-)-pinoresinol | | pinoresinol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| oplodiol | | carbobicyclic compound;
octahydronaphthalenes;
secondary alcohol;
sesquiterpenoid;
tertiary alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| roburic acid | | monocarboxylic acid;
olefinic compound;
tetracyclic triterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ginsenoside rc | | 12beta-hydroxy steroid;
beta-D-glucoside;
disaccharide derivative;
ginsenoside;
tetracyclic triterpenoid | hypoglycemic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ginsenoside rh1 | | 12beta-hydroxy steroid;
3beta-hydroxy-4,4-dimethylsteroid;
3beta-hydroxy steroid;
beta-D-glucoside;
ginsenoside;
tetracyclic triterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ginsenoside rb3 | | 12beta-hydroxy steroid;
beta-D-glucoside;
disaccharide derivative;
ginsenoside;
tetracyclic triterpenoid | antidepressant;
antioxidant;
cardioprotective agent;
neuroprotective agent;
NMDA receptor antagonist;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| eriodictyol 7-O-beta-D-glucopyranoside | | beta-D-glucoside;
flavanone glycoside;
monosaccharide derivative;
trihydroxyflavanone | plant metabolite;
radical scavenger | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4h-1-benzopyran-4-one | | alkaloid;
chromones;
hydroxypiperidine;
resorcinols;
tertiary amino compound | anti-inflammatory agent;
anti-ulcer drug;
anticholesteremic drug;
antileishmanial agent;
antineoplastic agent;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor;
fungal metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| astragaloside IV | | pentacyclic triterpenoid;
triterpenoid saponin | anti-inflammatory agent;
antioxidant;
EC 4.2.1.1 (carbonic anhydrase) inhibitor;
neuroprotective agent;
plant metabolite;
pro-angiogenic agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1-O-feruloyl-beta-D-glucose | | aromatic ether;
beta-D-glucoside;
cinnamate ester;
phenols | antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| astragaloside ii | | beta-D-glucoside;
monosaccharide derivative;
oxolanes;
pentacyclic triterpenoid;
triterpenoid saponin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ligstroside | | beta-D-glucoside;
diester;
methyl ester;
phenols;
pyrans;
secoiridoid glycoside | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 23-hydroxyursolic acid | | dihydroxy monocarboxylic acid;
pentacyclic triterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dihydroconiferyl alcohol glucoside | | beta-D-glucoside;
monomethoxybenzene;
monosaccharide derivative;
primary alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| oroxylin a-7-o-glucuronide | | beta-D-glucosiduronic acid;
glycosyloxyflavone;
monohydroxyflavone;
monomethoxyflavone;
monosaccharide derivative | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5-deoxystrigol | | indenofuran;
strigolactone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2,3-dihydrowithaferin A | | 27-hydroxy steroid;
4-hydroxy steroid;
delta-lactone;
epoxy steroid;
ergostanoid;
primary alcohol;
secondary alcohol;
withanolide | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| vibsanin b | | cyclic terpene ketone;
enone;
tertiary alcohol;
vibsane diterpenoid | plant growth retardant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| malonylgenistin | | beta-D-glucoside;
glycosyloxyisoflavone;
hydroxyisoflavone;
malonate ester;
monosaccharide derivative | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| adonixanthin | | carotenone;
cyclic ketone;
secondary alcohol | algal metabolite;
animal metabolite;
antineoplastic agent;
bacterial metabolite;
marine metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| niga-ichigoside f1 | | beta-D-glucoside;
monosaccharide derivative;
pentacyclic triterpenoid;
tetrol;
triterpenoid saponin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cinnamtannin a2 | | proanthocyanidin | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| benzoylaconine | | benzoate ester;
bridged compound;
diterpene alkaloid;
organic heteropolycyclic compound;
polyether;
secondary alcohol;
tertiary alcohol;
tertiary amino compound;
tetrol | phytotoxin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| miltiradiene | | abietadiene;
carbotricyclic compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tricin 4'-o-(threo-beta-guaiacylglyceryl) ether | | dimethoxybenzene;
flavonolignan;
polyphenol;
primary alcohol;
secondary alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| triptotriterpenic acid a | | diol;
hydroxy monocarboxylic acid;
pentacyclic triterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cycloeucalenone | | 3-oxo-5alpha-steroid;
cyclic terpene ketone;
pentacyclic triterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| deoxyaconitine | | acetate ester;
benzoate ester;
bridged compound;
diol;
diterpene alkaloid;
organic heteropolycyclic compound;
polyether;
secondary alcohol;
tertiary amino compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ginsenoside rg2 | | 12beta-hydroxy steroid;
20-hydroxy steroid;
3beta-hydroxy-4,4-dimethylsteroid;
3beta-hydroxy steroid;
beta-D-glucoside;
disaccharide derivative;
ginsenoside;
tetracyclic triterpenoid | anticoagulant;
cardioprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cauloside D | | carboxylic ester;
pentacyclic triterpenoid;
triterpenoid saponin | anti-inflammatory agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| oxypaeoniflora | | 4-hydroxybenzoate ester;
beta-D-glucoside;
bridged compound;
cyclic acetal;
lactol;
monoterpene glycoside | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one | | aromatic ether;
homoisoflavonoid;
polyphenol | angiogenesis modulating agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| vindolinine | | methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound;
tertiary amino compound | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| rubusoside | | beta-D-glucoside;
bridged compound;
steviol glycoside;
tetracyclic diterpenoid | plant metabolite;
sweetening agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| madecassoside | | carboxylic ester;
pentacyclic triterpenoid;
trisaccharide derivative;
triterpenoid saponin | anti-inflammatory agent;
antioxidant;
antirheumatic drug;
plant metabolite;
vulnerary | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| benzoylmesaconine | | benzoate ester;
bridged compound;
diterpene alkaloid;
organic heteropolycyclic compound;
polyether;
secondary alcohol;
tertiary alcohol;
tertiary amino compound;
tetrol | analgesic;
antiinfective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| albiflorin | | benzoate ester;
beta-D-glucoside;
bridged compound;
gamma-lactone;
monoterpene glycoside;
secondary alcohol | neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 6-tuliposide b | | 6-O-acyl-D-glucose;
enoate ester | antibacterial agent;
antifungal agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| quercetin 3-o-glucoside-7-o-rhamnoside | | beta-D-glucoside;
quercetin O-glucoside;
trihydroxyflavone | plant metabolite;
trypanocidal drug | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 10-nonacosanol | | secondary fatty alcohol;
ultra-long-chain fatty alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| (E)-sinapaldehyde 4-O-beta-D-glucopyranoside | | beta-D-glucoside;
cinnamaldehydes;
dimethoxybenzene;
monosaccharide derivative | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 1-(4-hydroxyphenyl)-7-phenyl-(6E)-hept-6-en-3-one | | diarylheptanoid;
ketone;
phenols | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| kurarinol | | 4'-hydroxyflavanones;
monomethoxyflavanone;
trihydroxyflavanone | anti-inflammatory agent;
antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 2,3-dihydro-3beta-O-sulfate withaferin A | | 27-hydroxy steroid;
4-hydroxy steroid;
delta-lactone;
epoxy steroid;
ergostanoid;
primary alcohol;
steroid sulfate;
withanolide | antineoplastic agent;
metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gypenoside XVII | | 12beta-hydroxy steroid;
beta-D-glucoside;
disaccharide derivative;
ginsenoside;
tetracyclic triterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| euonine | | acetate ester;
dihydroagarofuran sesquiterpenoid;
macrolide;
pyridine alkaloid;
sesquiterpene alkaloid | immunosuppressive agent;
insecticide;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| picrinine | | alkaloid ester;
indole alkaloid;
methyl ester;
organic heteropentacyclic compound;
polycyclic ether | analgesic;
anti-asthmatic agent;
anti-inflammatory agent;
antitussive;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| (20R)-ginsenoside Rg3 | | ginsenoside;
glycoside;
tetracyclic triterpenoid | antioxidant;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| epoxyazadiradione | | acetate ester;
cyclic terpene ketone;
epoxide;
furans;
limonoid;
pentacyclic triterpenoid | anti-inflammatory agent;
insecticide;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| n-(2-(5-methoxy-2-oxo-2,3-dihydro-1h-indol-3-yl)ethyl)acetamide | | acetamides;
hydroxyindoles;
tryptamines | antineoplastic agent;
apoptosis inducer;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ascorbic acid | | ascorbic acid;
vitamin C | coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent | 1964 | 2023 | 22.0 | low | 2 | 11 | 22 | 28 | 16 | 2 |
| salicylates | | monohydroxybenzoate | plant metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| orobanchol | | indenofuran;
secondary alcohol;
strigolactone | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| oleuropein aglycone | | catechols;
diester;
lactol;
methyl ester;
pyrans;
secoiridoid | anti-inflammatory agent;
antioxidant;
mTOR inhibitor;
neuroprotective agent;
plant metabolite;
TRPA1 channel agonist | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| stemmadenine | | Aspidosperma alkaloid;
methyl ester;
monoterpenoid indole alkaloid;
organic heterotetracyclic compound;
primary alcohol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| capilliposide b | | alpha-L-arabinopyranoside;
bridged compound;
cyclic ether;
diol;
hexacyclic triterpenoid;
hexanoate ester;
lactol;
secondary alcohol;
tetrasaccharide derivative;
triterpenoid saponin | antineoplastic agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| paeoniflorigenone | | alicyclic ketone;
benzoate ester;
bridged compound;
cyclic acetal;
lactol;
monoterpenoid | neuromuscular agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| maysin | | disaccharide derivative;
flavone C-glycoside;
secondary alpha-hydroxy ketone;
tetrahydroxyflavone | insecticide;
neuroprotective agent;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cryptocaryol a | | 2-pyranones;
pentol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| gypenoside LXXV | | 12beta-hydroxy steroid;
3beta-hydroxy-4,4-dimethylsteroid;
3beta-hydroxy steroid;
beta-D-glucoside;
disaccharide derivative;
ginsenoside;
tetracyclic triterpenoid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| chrysopine | | amino acid opine;
carboxamide;
delta-lactone;
secondary amino compound;
spiroketal;
triol | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ebc-46 | | diester;
diterpenoid;
organic heteropentacyclic compound;
phorbol ester | antineoplastic agent;
plant metabolite;
protein kinase C agonist | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| wilforgine | | acetate ester;
dihydroagarofuran sesquiterpenoid;
furans;
macrocyclic lactone;
organic heteropentacyclic compound;
pyridine alkaloid | plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dehydrotomatine | | alkaloid antibiotic;
glycoside;
steroid alkaloid;
tetrasaccharide derivative | antifungal agent;
phytotoxin;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| biliatresone | | aromatic ether;
aromatic ketone;
benzodioxoles;
enone;
phenols | plant metabolite;
toxin | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| cyclic gmp | | 3',5'-cyclic purine nucleotide;
guanyl ribonucleotide | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1987 | 2002 | 29.2 | low | 0 | 1 | 3 | 2 | 0 | 0 |
| deoxyinosine | | purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| deoxyguanosine triphosphate | | deoxyguanosine phosphate;
guanyl deoxyribonucleotide;
purine 2'-deoxyribonucleoside 5'-triphosphate | Arabidopsis thaliana metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| guanosine diphosphate mannose | | GDP-D-mannose | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| arachidonic acid | | icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid | Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite | 1947 | 2023 | 25.8 | low | 39 | 234 | 334 | 205 | 177 | 32 |
| palmitoleic acid | | hexadec-9-enoic acid | algal metabolite;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
human blood serum metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| eicosapentaenoic acid | | icosapentaenoic acid;
omega-3 fatty acid | anticholesteremic drug;
antidepressant;
antineoplastic agent;
Daphnia galeata metabolite;
fungal metabolite;
micronutrient;
mouse metabolite;
nutraceutical | 1980 | 2023 | 19.9 | low | 34 | 27 | 93 | 66 | 93 | 14 |
| 2-keto-4-methylvalerate | | 2-oxo monocarboxylic acid;
branched-chain keto acid | algal metabolite;
human metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| phloroglucinol | | benzenetriol;
phenolic donor | algal metabolite | 2007 | 2012 | 14.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| lactic acid | | 2-hydroxy monocarboxylic acid | algal metabolite;
Daphnia magna metabolite | 1982 | 2020 | 18.7 | low | 0 | 2 | 2 | 6 | 5 | 0 |
| 3-phosphoglycerate | | monophosphoglyceric acid;
tetronic acid derivative | algal metabolite;
fundamental metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glycerol | | alditol;
triol | algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent | 1964 | 2023 | 23.2 | low | 3 | 10 | 6 | 10 | 9 | 4 |
| alpha-glycerophosphoric acid | | glycerol monophosphate | algal metabolite;
human metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| hydroxylamine | | hydroxylamines | algal metabolite;
bacterial xenobiotic metabolite;
EC 1.1.3.13 (alcohol oxidase) inhibitor;
EC 4.2.1.22 (cystathionine beta-synthase) inhibitor;
EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor;
nitric oxide donor;
nucleophilic reagent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| phosphoric acid | | phosphoric acids | algal metabolite;
fertilizer;
human metabolite;
NMR chemical shift reference compound;
solvent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| phosphorylethanolamine | | phosphoethanolamine;
primary amino compound | algal metabolite;
human metabolite;
mouse metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| dimethyl sulfide | | aliphatic sulfide | algal metabolite;
bacterial xenobiotic metabolite;
EC 3.5.1.4 (amidase) inhibitor;
Escherichia coli metabolite;
marine metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| tramiprosate | | amino sulfonic acid;
zwitterion | algal metabolite;
anti-inflammatory agent;
anticonvulsant;
GABA agonist;
nootropic agent | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| acetohydroxamic acid | | acetohydroxamic acids;
carbohydroximic acid | algal metabolite;
EC 3.5.1.5 (urease) inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methylene bromide | | bromohydrocarbon;
bromomethanes | algal metabolite;
marine metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| harmalol | | harmala alkaloid | algal metabolite;
EC 1.4.3.4 (monoamine oxidase) inhibitor | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| isonicotinic acid | | pyridinemonocarboxylic acid | algal metabolite;
human metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| serine | | L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1964 | 2023 | 22.0 | low | 0 | 3 | 1 | 4 | 2 | 3 |
| sucrose | | glycosyl glycoside | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent | 1964 | 2022 | 21.7 | low | 2 | 5 | 6 | 11 | 3 | 4 |
| ornithine | | non-proteinogenic L-alpha-amino acid;
ornithine | algal metabolite;
hepatoprotective agent;
mouse metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| histidine | | amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 1994 | 2011 | 21.2 | low | 0 | 0 | 2 | 7 | 1 | 0 |
| valine | | L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 2001 | 2022 | 13.5 | low | 0 | 0 | 0 | 4 | 1 | 1 |
| methyl bromide | | bromohydrocarbon;
bromomethanes;
methyl halides | algal metabolite;
fumigant insecticide;
marine metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 3-mercaptopropionic acid | | mercaptopropanoic acid | algal metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| pyrrolidonecarboxylic acid | | 5-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid | algal metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| ethylene dibromide | | bromoalkane;
bromohydrocarbon | algal metabolite;
carcinogenic agent;
fumigant;
marine metabolite;
mouse metabolite;
mutagen | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| margaric acid | | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
mammalian metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| myristic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite | 1984 | 2021 | 21.4 | low | 1 | 4 | 17 | 14 | 10 | 1 |
| 2-hydroxybutyric acid | | 2-hydroxy monocarboxylic acid;
hydroxybutyric acid | algal metabolite;
human metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| homoserine | | amino acid zwitterion;
homoserine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| methylphosphate | | monoalkyl phosphate;
one-carbon compound | algal metabolite;
epitope;
phosphoantigen | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glycerol 1-stearate | | 1-acylglycerol 18:0;
rac-1-monoacylglycerol | algal metabolite;
Caenorhabditis elegans metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| butyl stearate | | fatty acid ester | algal metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| beta-aminoglutaric acid | | dicarboxylic acid | algal metabolite;
marine metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| glucuronic acid | | D-glucuronic acid | algal metabolite | 1999 | 2015 | 14.7 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| 2-palmitoylglycerol | | 2-acylglycerol 16:0 | algal metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 6-bromo-3-(bromomethyl)-7-methyl-2,3,7-trichloro-1-octene | | monoterpenoid;
organobromine compound;
organochlorine compound | algal metabolite;
antineoplastic agent;
marine metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| proline | | amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid | algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 1991 | 2020 | 13.0 | low | 0 | 0 | 1 | 2 | 5 | 0 |
| altritol | | hexitol | algal metabolite;
marine metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| 5'-methylthioadenosine | | thioadenosine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| d-2-hydroxyglutarate | | 2-hydroxyglutaric acid | algal metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| docosahexaenoate | | docosahexaenoic acid;
omega-3 fatty acid | algal metabolite;
antineoplastic agent;
Daphnia tenebrosa metabolite;
human metabolite;
mouse metabolite;
nutraceutical | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| domoic acid | | L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid;
tricarboxylic acid | algal metabolite;
hapten;
marine metabolite;
neuromuscular agent;
neurotoxin | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| docosapentaenoic acid | | docosapentaenoic acid;
omega-3 fatty acid | algal metabolite;
human metabolite | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| debromoaplysiatoxin | | aplysiatoxins;
cyclic hemiketal;
ether;
organic heterotricyclic compound;
phenols;
secondary alcohol;
spiroketal | algal metabolite;
carcinogenic agent;
cyanotoxin;
marine metabolite;
protein kinase C agonist | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| aplysiatoxin | | aplysiatoxins;
bromophenol;
cyclic hemiketal;
ether;
organic heterotricyclic compound;
secondary alcohol;
spiroketal | algal metabolite;
carcinogenic agent;
cyanotoxin;
marine metabolite;
protein kinase C agonist | 0 | 0 | | low | 0 | 0 | 0 | 0 | 0 | 0 |
| guanine | | 2-aminopurines;
oxopurine;
purine nucleobase | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1995 | 2008 | 22.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| protocatechuic acid | | catechols;
dihydroxybenzoic acid | antineoplastic agent;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor;
human xenobiotic metabolite;
plant metabolite | 2011 | 2012 | 12.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 4-hydroxybenzaldehyde | | hydroxybenzaldehyde | EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 4-hydroxybenzoic acid | | monohydroxybenzoic acid | algal metabolite;
plant metabolite | 1982 | 2011 | 23.0 | low | 0 | 1 | 0 | 1 | 1 | 0 |
| acetic acid | | monocarboxylic acid | antimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzaldehyde | | benzaldehydes | EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
EC 3.5.5.1 (nitrilase) inhibitor;
flavouring agent;
fragrance;
odorant receptor agonist;
plant metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzoic acid | | benzoic acids | algal metabolite;
antimicrobial food preservative;
drug allergen;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
human xenobiotic metabolite;
plant metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| butyric acid | | fatty acid 4:0;
straight-chain saturated fatty acid | human urinary metabolite;
Mycoplasma genitalium metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| catechol | | catechols | allelochemical;
genotoxin;
plant metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-cresol | | cresol | human xenobiotic metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| salicylic acid | | monohydroxybenzoic acid | algal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 3-methylcatechol | | methylcatechol | bacterial xenobiotic metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-cresol | | cresol | human xenobiotic metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| gallic acid | | trihydroxybenzoic acid | antineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite | 2011 | 2012 | 12.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| octanoic acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | antibacterial agent;
Escherichia coli metabolite;
human metabolite | 1982 | 2012 | 22.7 | low | 0 | 1 | 0 | 1 | 1 | 0 |
| 4-aminophenol | | aminophenol | allergen;
metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| guaiacol | | guaiacols | disinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| pyrrolidonecarboxylic acid | | oxoproline;
pyrrolidin-2-ones;
pyrrolidinemonocarboxylic acid | human metabolite | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| pipecolic acid | | piperidinemonocarboxylic acid | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| acetanilide | | acetamides;
anilide | analgesic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-nitrophenol | | 4-nitrophenols | human xenobiotic metabolite;
mouse metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| palmitic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor;
plant metabolite | 1982 | 2019 | 17.8 | low | 0 | 1 | 0 | 6 | 5 | 0 |
| pentachlorophenol | | aromatic fungicide;
chlorophenol;
organochlorine pesticide;
pentachlorobenzenes | human xenobiotic metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| phenol | | phenols | antiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| propionic acid | | saturated fatty acid;
short-chain fatty acid | antifungal drug | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pyrogallol | | benzenetriol;
phenolic donor | plant metabolite | 2005 | 2010 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| 1-anilino-8-naphthalenesulfonate | | aminonaphthalene;
naphthalenesulfonic acid | fluorescent probe | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-aminobenzamidine | | | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| phenytoin | | imidazolidine-2,4-dione | anticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 7,8-dihydroxyflavone | | dihydroxyflavone | antidepressant;
antineoplastic agent;
antioxidant;
plant metabolite;
tropomyosin-related kinase B receptor agonist | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| salophen | | carbonyl compound | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Acetylpheneturide | | organic molecular entity | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| albendazole | | aryl sulfide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester | anthelminthic drug;
microtubule-destabilising agent;
tubulin modulator | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aminoglutethimide | | dicarboximide;
piperidones;
substituted aniline | adrenergic agent;
anticonvulsant;
antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-amino-3-hydroxybutyric acid | | 3-hydroxy monocarboxylic acid;
amino acid zwitterion;
gamma-amino acid | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| amlexanox | | monocarboxylic acid;
pyridochromene | anti-allergic agent;
anti-ulcer drug;
non-steroidal anti-inflammatory drug | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| amlodipine | | dihydropyridine;
ethyl ester;
methyl ester;
monochlorobenzenes;
primary amino compound | antihypertensive agent;
calcium channel blocker;
vasodilator agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| amodiaquine | | aminoquinoline;
organochlorine compound;
phenols;
secondary amino compound;
tertiary amino compound | anticoronaviral agent;
antimalarial;
drug allergen;
EC 2.1.1.8 (histamine N-methyltransferase) inhibitor;
non-steroidal anti-inflammatory drug;
prodrug | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| arecoline | | enoate ester;
methyl ester;
pyridine alkaloid;
tetrahydropyridine | metabolite;
muscarinic agonist | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aristolochic acid i | | aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound | carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| arotinolol | | aromatic amide;
thiophenes | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aspirin | | benzoic acids;
phenyl acetates;
salicylates | anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| atenolol | | ethanolamines;
monocarboxylic acid amide;
propanolamine | anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
environmental contaminant;
sympatholytic agent;
xenobiotic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| atrazine | | chloro-1,3,5-triazine;
diamino-1,3,5-triazine | environmental contaminant;
herbicide;
xenobiotic | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| benzocaine | | benzoate ester;
substituted aniline | allergen;
antipruritic drug;
sensitiser;
topical anaesthetic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| berberine | | alkaloid antibiotic;
berberine alkaloid;
botanical anti-fungal agent;
organic heteropentacyclic compound | antilipemic drug;
antineoplastic agent;
antioxidant;
EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor;
EC 1.21.3.3 (reticuline oxidase) inhibitor;
EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.11.10 (IkappaB kinase) inhibitor;
EC 3.1.1.4 (phospholipase A2) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
hypoglycemic agent;
metabolite;
potassium channel blocker | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| biperiden | | piperidines;
tertiary alcohol;
tertiary amino compound | antidote to sarin poisoning;
antidyskinesia agent;
antiparkinson drug;
muscarinic antagonist;
parasympatholytic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bupivacaine | | aromatic amide;
piperidinecarboxamide;
tertiary amino compound | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| verapamil | | aromatic ether;
nitrile;
polyether;
tertiary amino compound | | 2003 | 2012 | 16.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| cannabinol | | dibenzopyran | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| carbamazepine | | dibenzoazepine;
ureas | analgesic;
anticonvulsant;
antimanic drug;
drug allergen;
EC 3.5.1.98 (histone deacetylase) inhibitor;
environmental contaminant;
glutamate transporter activator;
mitogen;
non-narcotic analgesic;
sodium channel blocker;
xenobiotic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| carbetapentane | | benzenes | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| carbofuran | | 1-benzofurans;
carbamate ester | acaricide;
agrochemical;
avicide;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
nematicide | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| carbonyl cyanide m-chlorophenyl hydrazone | | hydrazone;
monochlorobenzenes;
nitrile | antibacterial agent;
geroprotector;
ionophore | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cetyl alcohol | | hexadecanol;
long-chain primary fatty alcohol | algal metabolite;
flavouring agent;
human metabolite;
plant metabolite | 2011 | 2017 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| chloroquine | | aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound | anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| chlorpromazine | | organochlorine compound;
phenothiazines;
tertiary amine | anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ciprofloxacin | | aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion | antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| clobazam | | 1,4-benzodiazepinone;
organochlorine compound | anticonvulsant;
anxiolytic drug;
GABA modulator | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| clonazepam | | 1,4-benzodiazepinone;
monochlorobenzenes | anticonvulsant;
anxiolytic drug;
GABA modulator | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-cresol | | cresol | Escherichia coli metabolite;
human metabolite;
uremic toxin | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| cycloleucine | | non-proteinogenic alpha-amino acid | EC 2.5.1.6 (methionine adenosyltransferase) inhibitor | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cyclothiazide | | benzothiadiazine | antihypertensive agent;
diuretic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| decanoic acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
anti-inflammatory agent;
antibacterial agent;
human metabolite;
plant metabolite;
volatile oil component | 1982 | 2012 | 22.7 | low | 0 | 1 | 0 | 1 | 1 | 0 |
| dimethadione | | oxazolidinone | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| valproic acid | | branched-chain fatty acid;
branched-chain saturated fatty acid | anticonvulsant;
antimanic drug;
EC 3.5.1.98 (histone deacetylase) inhibitor;
GABA agent;
neuroprotective agent;
psychotropic drug;
teratogenic agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ethosuximide | | dicarboximide;
pyrrolidinone | anticonvulsant;
geroprotector;
T-type calcium channel blocker | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ethotoin | | imidazolidine-2,4-dione | anticonvulsant | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| felbamate | | carbamate ester | anticonvulsant;
neuroprotective agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| felodipine | | dichlorobenzene;
dihydropyridine;
ethyl ester;
methyl ester | anti-arrhythmia drug;
antihypertensive agent;
calcium channel blocker;
vasodilator agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fexofenadine | | piperidines;
tertiary amine | anti-allergic agent;
H1-receptor antagonist | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gabapentin | | gamma-amino acid | anticonvulsant;
calcium channel blocker;
environmental contaminant;
xenobiotic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| gliclazide | | N-sulfonylurea | hypoglycemic agent;
insulin secretagogue;
radical scavenger | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glimepiride | | sulfonamide | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glutethimide | | piperidines | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| guvacine | | alpha,beta-unsaturated monocarboxylic acid;
beta-amino acid;
pyridine alkaloid;
secondary amino compound;
tetrahydropyridine | GABA reuptake inhibitor;
plant metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| halothane | | haloalkane;
organobromine compound;
organochlorine compound;
organofluorine compound | inhalation anaesthetic | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| hexachlorophene | | bridged diphenyl fungicide;
polyphenol;
trichlorobenzene | acaricide;
antibacterial agent;
antifungal agrochemical;
antiseptic drug | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ibuprofen | | monocarboxylic acid | antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ifosfamide | | ifosfamides | alkylating agent;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
xenobiotic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| indomethacin | | aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole | analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic | 2001 | 2020 | 17.2 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| iproniazid | | carbohydrazide;
pyridines | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| isoniazid | | carbohydrazide | antitubercular agent;
drug allergen | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| juglone | | hydroxy-1,4-naphthoquinone | geroprotector;
herbicide;
reactive oxygen species generator | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| lamotrigine | | 1,2,4-triazines;
dichlorobenzene;
primary arylamine | anticonvulsant;
antidepressant;
antimanic drug;
calcium channel blocker;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
excitatory amino acid antagonist;
geroprotector;
non-narcotic analgesic;
xenobiotic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| lauric acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
antibacterial agent;
plant metabolite | 1982 | 2012 | 20.2 | low | 0 | 1 | 0 | 1 | 2 | 0 |
| letrozole | | nitrile;
triazoles | antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| vitamin k 3 | | 1,4-naphthoquinones;
vitamin K | angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| mephenytoin | | imidazolidine-2,4-dione | anticonvulsant | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| metharbital | | organic molecular entity | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methyl salicylate | | benzoate ester;
methyl ester;
salicylates | flavouring agent;
insect attractant;
metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| moclobemide | | benzamides;
monochlorobenzenes;
morpholines | antidepressant;
environmental contaminant;
xenobiotic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| acecainide | | acetamides;
benzamides | anti-arrhythmia drug | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| deoxyepinephrine | | catecholamine | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nicardipine | | benzenes;
C-nitro compound;
diester;
dihydropyridine;
methyl ester;
tertiary amino compound | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nifedipine | | C-nitro compound;
dihydropyridine;
methyl ester | calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nimesulide | | aromatic ether;
C-nitro compound;
sulfonamide | cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nimetazepam | | 1,4-benzodiazepinone;
C-nitro compound | anticonvulsant;
antispasmodic drug;
GABA modulator;
sedative | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nimodipine | | 2-methoxyethyl ester;
C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
isopropyl ester | antihypertensive agent;
calcium channel blocker;
cardiovascular drug;
vasodilator agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nipecotic acid | | beta-amino acid;
piperidinemonocarboxylic acid | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nisoldipine | | C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
methyl ester | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nitrazepam | | 1,4-benzodiazepinone;
C-nitro compound | anticonvulsant;
antispasmodic drug;
drug metabolite;
GABA modulator;
sedative | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nitrendipine | | C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
ethyl ester;
methyl ester | antihypertensive agent;
calcium channel blocker;
geroprotector;
vasodilator agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide | | aromatic ether;
C-nitro compound;
sulfonamide | antineoplastic agent;
cyclooxygenase 2 inhibitor | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| oxaprozin | | 1,3-oxazoles;
monocarboxylic acid | analgesic;
non-steroidal anti-inflammatory drug | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 4-chlorophenol | | monochlorophenol | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| phenacemide | | acetamides | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| phenobarbital | | barbiturates | anticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| primidone | | pyrimidone | anticonvulsant;
environmental contaminant;
xenobiotic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| resorcinol | | benzenediol;
phenolic donor;
resorcinols | erythropoietin inhibitor;
sensitiser | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| riluzole | | benzothiazoles | | 2003 | 2014 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| rofecoxib | | butenolide;
sulfone | analgesic;
cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| stearic acid | | long-chain fatty acid;
saturated fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
human metabolite;
plant metabolite | 1982 | 2012 | 18.9 | low | 0 | 1 | 0 | 4 | 3 | 0 |
| sulfanilamide | | substituted aniline;
sulfonamide antibiotic;
sulfonamide | antibacterial agent;
drug allergen;
EC 4.2.1.1 (carbonic anhydrase) inhibitor | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sulthiame | | organic molecular entity | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| trimethadione | | oxazolidinone | anticonvulsant;
geroprotector | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| vigabatrin | | gamma-amino acid | anticonvulsant;
EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| zonisamide | | 1,2-benzoxazoles;
sulfonamide | anticonvulsant;
antioxidant;
central nervous system drug;
protective agent;
T-type calcium channel blocker | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| prednisolone | | 11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
drug metabolite;
environmental contaminant;
immunosuppressive agent;
xenobiotic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-aminophenol | | aminophenol | bacterial metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| carbachol | | ammonium salt;
carbamate ester | cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| metaraminol | | phenylethanolamines | alpha-adrenergic agonist;
sympathomimetic agent;
vasoconstrictor agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| desoxycorticosterone acetate | | corticosteroid hormone | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| physostigmine | | carbamate ester;
indole alkaloid | antidote to curare poisoning;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,3,4,6-tetrachlorophenol | | tetrachlorophenol | xenobiotic metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ampicillin | | beta-lactam antibiotic;
penicillin allergen;
penicillin | antibacterial drug | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bromoethane | | bromoalkane;
bromohydrocarbon;
volatile organic compound | alkylating agent;
carcinogenic agent;
local anaesthetic;
refrigerant;
solvent | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phencyclidine | | benzenes;
piperidines | anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| caramiphen | | benzenes | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methsuximide | | organic molecular entity | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| phthalimide | | phthalimides | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| phensuximide | | pyrrolidines | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| amido-g-acid | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,4,6-trichlorophenol | | trichlorophenol | carcinogenic agent | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 2-tert-butylphenol | | alkylbenzene | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 2-isopropylphenol | | phenols | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 2-nitrophenol | | 2-nitrophenols | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| picric acid | | C-nitro compound | antiseptic drug;
explosive;
fixative | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| thymol | | monoterpenoid;
phenols | volatile oil component | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 2-ethylphenol | | phenols | | 1982 | 1982 | 42.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| salicylaldehyde | | hydroxybenzaldehyde | nematicide;
plant metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 2-phenylphenol | | hydroxybiphenyls | antifungal agrochemical;
environmental food contaminant | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 4-phenylphenol | | hydroxybiphenyls | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| veratric acid | | benzoic acids | allergen;
plant metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| acetyleugenol | | benzoate ester;
phenols | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-chlorophenol | | 2-halophenol;
monochlorophenol | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 2,4,5-trichlorophenol | | trichlorophenol | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| butylphen | | phenols | allergen | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| methylparaben | | paraben | antifungal agent;
antimicrobial food preservative;
neuroprotective agent;
plant metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 4-isopropylphenol | | phenols | flavouring agent | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 4-anisic acid | | methoxybenzoic acid | plant metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| anisole | | monomethoxybenzene | plant metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cyclopentamine | | secondary amino compound | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| caprolactam | | caprolactams | human blood serum metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-bromophenol | | bromophenol | human urinary metabolite;
human xenobiotic metabolite;
marine metabolite;
mouse metabolite;
persistent organic pollutant;
rat metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| heptanoic acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | plant metabolite | 1982 | 1982 | 42.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| pelargonic acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
antifeedant;
Daphnia magna metabolite;
plant metabolite | 1982 | 2010 | 28.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| n-decyl alcohol | | decanol;
primary alcohol | metabolite;
pheromone;
protic solvent | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| undecanoic acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | antifungal agent;
human metabolite | 1982 | 2010 | 28.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| dodecanol | | dodecanol;
primary alcohol | bacterial metabolite;
cosmetic;
insect attractant;
insecticide;
pheromone;
plant metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| myristyl alcohol | | long-chain primary fatty alcohol;
tetradecanol | pheromone;
plant metabolite;
volatile oil component | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| behenic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| mephobarbital | | barbiturates | anticonvulsant | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| paramethadione | | oxazolidinone | anticonvulsant | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3,4,5-trimethoxybenzoic acid | | benzoic acids;
methoxybenzenes | human urinary metabolite;
human xenobiotic metabolite;
plant metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,4-dichlorophenol | | dichlorophenol | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| cyclopentanone | | cyclopentanones | Maillard reaction product | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| vanillic acid | | methoxybenzoic acid;
monohydroxybenzoic acid | plant metabolite | 2010 | 2012 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| hexanoic acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | human metabolite;
plant metabolite | 2011 | 2012 | 12.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| catechin | | catechin | antioxidant;
plant metabolite | 2005 | 2010 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| benactyzine | | diarylmethane | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,5-dinitrophenol | | dinitrophenol | | 1982 | 1982 | 42.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| phetharbital | | barbiturates | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| prenylamine | | diarylmethane | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| imperatorin | | psoralens | EC 3.1.1.7 (acetylcholinesterase) inhibitor;
metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| carvacrol | | botanical anti-fungal agent;
p-menthane monoterpenoid;
phenols | agrochemical;
antimicrobial agent;
flavouring agent;
TRPA1 channel agonist;
volatile oil component | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| beclamide | | benzenes | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| phloretic acid | | hydroxy monocarboxylic acid | plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| orcinol | | 5-alkylresorcinol;
dihydroxytoluene | Aspergillus metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| margaric acid | | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
mammalian metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| arachidic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| oleanolic acid | | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,4,6-trimethylphenol | | hydroxytoluene | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| herniarin | | coumarins | fluorochrome | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| chlormethiazole | | thiazoles | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glybuthiazol | | benzenes;
sulfonamide | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| myristic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite | 1982 | 2012 | 20.6 | low | 0 | 1 | 0 | 6 | 2 | 0 |
| 3-nitrophenol | | 3-nitrophenols | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| lignoceric acid | | straight-chain saturated fatty acid;
very long-chain fatty acid | Daphnia tenebrosa metabolite;
human metabolite;
plant metabolite;
volatile oil component | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-aminophenol | | aminophenol | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Berberine chloride (TN) | | organic molecular entity | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tridecanoic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | plant metabolite | 1982 | 2010 | 28.0 | high | 0 | 1 | 0 | 1 | 0 | 0 |
| nonadecanoic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | fungal metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-(2'-hydroxyphenyl)benzoxazole | | 1,3-benzoxazoles;
phenols | geroprotector | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pentadecanoic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
food component;
human blood serum metabolite;
plant metabolite | 2001 | 2006 | 20.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| ethambutol | | ethanolamines;
ethylenediamine derivative | antitubercular agent;
environmental contaminant;
xenobiotic | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| d-alpha tocopherol | | alpha-tocopherol | algal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite | 2007 | 2010 | 16.0 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| 2-tert-butylhydroquinone | | hydroquinones | food antioxidant | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| menthol | | p-menthan-3-ol | antipruritic drug;
antispasmodic drug;
antitussive | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| heneicosanoic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | | 2010 | 2010 | 14.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| tricosanoic acid | | straight-chain saturated fatty acid;
very long-chain fatty acid | Daphnia magna metabolite;
human metabolite;
plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pronarcon | | barbiturates | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| improsan | | organosulfonic ester | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| iproclozide | | aromatic ether | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| aminopentamide | | diarylmethane | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| sodium selenate | | inorganic sodium salt | anticonvulsant;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
fertilizer | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tomatine | | alkaloid antibiotic;
glycoalkaloid;
glycoside;
steroid alkaloid;
tetrasaccharide derivative | antifungal agent;
immunological adjuvant;
phytotoxin | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| benomyl | | aromatic amide;
benzimidazole fungicide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester | acaricide;
anthelminthic drug;
antifungal agrochemical;
microtubule-destabilising agent;
tubulin modulator | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| alclofenac | | aromatic ether;
monocarboxylic acid;
monochlorobenzenes | drug allergen;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-ethylphenol | | phenols | fungal xenobiotic metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 4-anisaldehyde | | benzaldehydes | bacterial metabolite;
human urinary metabolite;
insect repellent;
plant metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| butylated hydroxytoluene | | phenols | antioxidant;
ferroptosis inhibitor;
food additive;
geroprotector | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| carticaine | | thiophenecarboxylic acid | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| amoscanate | | C-nitro compound;
isothiocyanate;
secondary amino compound | schistosomicide drug | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| amoxicillin | | penicillin allergen;
penicillin | antibacterial drug | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| eterobarb | | barbiturates | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| adinazolam | | triazolobenzodiazepine | anticonvulsant;
antidepressant;
anxiolytic drug;
sedative | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| diltiazem | | 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate | antihypertensive agent;
calcium channel blocker;
vasodilator agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| progabide | | diarylmethane | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| lidamidine | | ureas | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| acifran | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| simvastatin | | delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
statin (semi-synthetic) | EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor;
EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor;
ferroptosis inducer;
geroprotector;
prodrug | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| tiagabine | | beta-amino acid;
piperidinemonocarboxylic acid;
tertiary amino compound;
thiophenes | anticonvulsant;
GABA reuptake inhibitor | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| adenosine | | adenosines;
purines D-ribonucleoside | analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| octyl gallate | | gallate ester | food antioxidant;
hypoglycemic agent;
plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| d-lactic acid | | 2-hydroxypropanoic acid | Escherichia coli metabolite;
human metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-vinylphenol | | phenols | human urinary metabolite;
human xenobiotic metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| heptenophos | | organochlorine compound;
organophosphate insecticide;
trialkyl phosphate | acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ursolic acid | | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | geroprotector;
plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| baicalin | | dihydroxyflavone;
glucosiduronic acid;
glycosyloxyflavone;
monosaccharide derivative | antiatherosclerotic agent;
antibacterial agent;
anticoronaviral agent;
antineoplastic agent;
antioxidant;
cardioprotective agent;
EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
ferroptosis inhibitor;
neuroprotective agent;
non-steroidal anti-inflammatory drug;
plant metabolite;
prodrug | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| allicin | | botanical anti-fungal agent;
sulfoxide | antibacterial agent | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| epigallocatechin gallate | | flavans;
gallate ester;
polyphenol | antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| alpha-terthienyl | | terthiophene | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gallocatechol | | gallocatechin | antioxidant;
metabolite;
radical scavenger | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| rutecarpine | | beta-carbolines | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| trihexyphenidyl hydrochloride | | aralkylamine | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| g 29505 | | methoxybenzenes | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pinocembrin | | (2S)-flavan-4-one;
dihydroxyflavanone | antineoplastic agent;
antioxidant;
metabolite;
neuroprotective agent;
vasodilator agent | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| chavicol | | phenols;
phenylpropanoid | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| acefylline | | oxopurine | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-hydroxychavicol | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dipropylacetamide | | fatty amide | geroprotector;
metabolite;
teratogenic agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aceclofenac | | amino acid;
carboxylic ester;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound | EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| amphotalide | | phthalimides | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| fluoresone | | sulfonamide | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| alacepril | | dipeptide;
thioacetate ester | EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| avarol | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| epicatechin | | catechin;
polyphenol | antioxidant | 2005 | 2010 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| tetrahydropalmatine | | an (S)-7,8,13,14-tetrahydroprotoberberine;
berberine alkaloid;
organic heterotetracyclic compound | adrenergic agent;
dopaminergic antagonist;
non-narcotic analgesic | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| alantolactone | | naphthofuran;
olefinic compound;
sesquiterpene lactone | antineoplastic agent;
apoptosis inducer;
plant metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| (-)-catechin | | catechin | metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| isoalantolactone | | eudesmane sesquiterpenoid;
sesquiterpene lactone | antifungal agent;
apoptosis inducer;
plant metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fangchinoline | | aromatic ether;
bisbenzylisoquinoline alkaloid;
macrocycle | anti-HIV-1 agent;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
neuroprotective agent;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| agroclavine | | ergot alkaloid | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tryptanthrine | | alkaloid antibiotic;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| n-(hydroxymethyl)nicotinamide | | pyridinecarboxamide | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4'-methoxyflavone | | ether;
flavonoids | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| rosiglitazone | | aminopyridine;
thiazolidinediones | EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
insulin-sensitizing drug | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 5-chloroindole | | | | 2022 | 2022 | 2.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 |
| n-acetyltyrosine, (dl)-isomer | | N-acetyl-amino acid;
phenols;
tyrosine derivative | human urinary metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| aucubin | | organic molecular entity | metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| catalpol | | organic molecular entity | metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| rac-glycerol 1-monodecanoate | | rac-1-monoacylglycerol | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 7-chloro-4-aminoquinoline | | aminoquinoline | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| epicatechin gallate | | catechin;
gallate ester;
polyphenol | EC 3.2.1.1 (alpha-amylase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| triptolide | | diterpenoid;
epoxide;
gamma-lactam;
organic heteroheptacyclic compound | antispermatogenic agent;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| parthenolide | | germacranolide | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| parecoxib | | isoxazoles;
N-sulfonylcarboxamide | cyclooxygenase 2 inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| medica 16 | | alpha,omega-dicarboxylic acid | antilipemic drug;
EC 2.3.3.8 (ATP citrate synthase) inhibitor;
EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor;
G-protein-coupled receptor agonist;
hypoglycemic agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cyanidin | | 5-hydroxyanthocyanidin | antioxidant;
metabolite;
neuroprotective agent | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| proline | | amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid | algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| camphora | | camphor | | 2003 | 2010 | 17.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| rhodioloside | | glycoside | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tevenel | | sulfonamide | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| dihydrosterculic acid | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fluoracizine | | phenothiazines | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dihydroguaiaretic acid | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| anacardic acid | | hydroxy monocarboxylic acid;
hydroxybenzoic acid | anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
apoptosis inducer;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
neuroprotective agent;
plant metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| farglitazar | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-n-butyl-4,5-dihydrophthalide | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4'-o-methylepigallocatechin | | catechin | metabolite | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| scutellarin | | glucosiduronic acid;
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone | antineoplastic agent;
proteasome inhibitor | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ergolide | | acetate ester;
cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
sesquiterpene lactone | anti-inflammatory agent;
antineoplastic agent;
metabolite;
NF-kappaB inhibitor;
plant metabolite | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| cirsimaritin | | dihydroxyflavone;
dimethoxyflavone | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| (-)-gallocatechin gallate | | catechin;
gallate ester;
polyphenol | antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human xenobiotic metabolite;
plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tenulin | | sesquiterpene lactone | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methyl 3,4-dihydroxybenzoate | | catechols;
methyl ester | antioxidant;
neuroprotective agent;
plant metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| jatrorrhizine chloride | | | | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| ritonavir | | 1,3-thiazoles;
carbamate ester;
carboxamide;
L-valine derivative;
ureas | antiviral drug;
environmental contaminant;
HIV protease inhibitor;
xenobiotic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| naringenin | | (2S)-flavan-4-one;
naringenin | expectorant;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cholesteryl glucoside | | monosaccharide derivative;
sterol 3-beta-D-glucoside | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| arbutin | | beta-D-glucoside;
monosaccharide derivative | Escherichia coli metabolite;
plant metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| epiafzelechin | | catechin | plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| e-z cinnamic acid | | cinnamic acid | plant metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| arachidonic acid | | icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid | Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite | 1998 | 2022 | 14.9 | low | 0 | 0 | 2 | 6 | 3 | 1 |
| resveratrol | | resveratrol | antioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| retinol | | retinol;
vitamin A | human metabolite;
mouse metabolite;
plant metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| docosahexaenoate | | docosahexaenoic acid;
omega-3 fatty acid | algal metabolite;
antineoplastic agent;
Daphnia tenebrosa metabolite;
human metabolite;
mouse metabolite;
nutraceutical | 2000 | 2022 | 14.9 | high | 0 | 0 | 1 | 5 | 3 | 1 |
| palmitoleic acid | | hexadec-9-enoic acid | algal metabolite;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
human blood serum metabolite | 1998 | 2017 | 14.5 | low | 0 | 0 | 1 | 1 | 2 | 0 |
| oleic acid | | octadec-9-enoic acid | antioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent | 1982 | 2022 | 16.0 | low | 0 | 1 | 1 | 11 | 8 | 1 |
| ferulic acid | | ferulic acids | anti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite | 2010 | 2012 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| (3R,5S)-fluvastatin | | (6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid;
statin (synthetic) | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| eicosapentaenoic acid | | icosapentaenoic acid;
omega-3 fatty acid | anticholesteremic drug;
antidepressant;
antineoplastic agent;
Daphnia galeata metabolite;
fungal metabolite;
micronutrient;
mouse metabolite;
nutraceutical | 1998 | 2019 | 17.0 | low | 0 | 0 | 1 | 3 | 2 | 0 |
| lycopene | | acyclic carotene | antioxidant;
plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| kazinol b | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methyl indole-3-carboxylate | | indoles;
methyl ester | metabolite | 2022 | 2022 | 2.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 |
| cinnamaldehyde | | 3-phenylprop-2-enal;
cinnamaldehydes | antifungal agent;
EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor;
flavouring agent;
hypoglycemic agent;
plant metabolite;
sensitiser;
vasodilator agent | 2005 | 2012 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| trans-4-coumaric acid | | 4-coumaric acid | food component;
mouse metabolite;
plant metabolite | 2010 | 2012 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Methylenedioxycinnamic acid | | hydroxycinnamic acid | | 2010 | 2010 | 14.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| cannabidiol | | olefinic compound;
phytocannabinoid;
resorcinols | antimicrobial agent;
plant metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cinromide | | cinnamamides;
secondary carboxamide | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| caffeic acid | | caffeic acid | geroprotector;
mouse metabolite | 2010 | 2012 | 13.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| isoferulic acid | | ferulic acids | antioxidant;
biomarker;
metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| flunarizine | | diarylmethane | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| benztropine | | diarylmethane | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| capsaicin | | capsaicinoid | non-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| chlorogenic acid | | cinnamate ester;
tannin | food component;
plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| albutoin | | organonitrogen compound;
organooxygen compound | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| adrafinil | | diarylmethane | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fraxetin | | aromatic ether;
hydroxycoumarin | anti-inflammatory agent;
antibacterial agent;
antimicrobial agent;
antioxidant;
apoptosis inducer;
apoptosis inhibitor;
Arabidopsis thaliana metabolite;
hepatoprotective agent;
hypoglycemic agent | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| quercetin | | 7-hydroxyflavonol;
pentahydroxyflavone | antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger | 2005 | 2012 | 14.5 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| coniferin | | aromatic ether;
cinnamyl alcohol beta-D-glucoside;
monosaccharide derivative | plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| biochanin a | | 4'-methoxyisoflavones;
7-hydroxyisoflavones | antineoplastic agent;
EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| formononetin | | 4'-methoxyisoflavones;
7-hydroxyisoflavones | phytoestrogen;
plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| acacetin | | dihydroxyflavone;
monomethoxyflavone | anticonvulsant;
plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| apigenin | | trihydroxyflavone | antineoplastic agent;
metabolite | 2005 | 2010 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| luteolin | | 3'-hydroxyflavonoid;
tetrahydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist | 2005 | 2010 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| quercitrin | | alpha-L-rhamnoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone | antileishmanial agent;
antioxidant;
EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| beta carotene | | carotenoid beta-end derivative;
cyclic carotene | antioxidant;
biological pigment;
cofactor;
ferroptosis inhibitor;
human metabolite;
mouse metabolite;
plant metabolite;
provitamin A | 2007 | 2010 | 15.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| daphnetin | | hydroxycoumarin | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 8,11,14-eicosatrienoic acid | | fatty acid 20:3;
long-chain fatty acid | fungal metabolite;
human metabolite;
nutraceutical | 1998 | 2019 | 15.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| alprostadil | | prostaglandins E | anticoagulant;
human metabolite;
platelet aggregation inhibitor;
vasodilator agent | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 15-hydroxy-5,8,11,13-eicosatetraenoic acid | | (5Z,8Z,11Z,13E)-15-HETE | human metabolite;
mouse metabolite | 2009 | 2009 | 15.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| vitamin d 2 | | hydroxy seco-steroid;
seco-ergostane;
vitamin D | bone density conservation agent;
nutraceutical;
plant metabolite;
rodenticide | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| quercetin 3-o-glucopyranoside | | beta-D-glucoside;
monosaccharide derivative;
quercetin O-glucoside;
tetrahydroxyflavone | antineoplastic agent;
antioxidant;
antipruritic drug;
bone density conservation agent;
geroprotector;
histamine antagonist;
osteogenesis regulator;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| rutin | | disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone | antioxidant;
metabolite | 2011 | 2012 | 12.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| kaempferol | | 7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone | antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite | 2005 | 2012 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| gamma-linolenic acid | | linolenic acid;
omega-6 fatty acid | human metabolite;
mouse metabolite;
plant metabolite | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| alpha-linolenic acid | | linolenic acid;
omega-3 fatty acid | micronutrient;
mouse metabolite;
nutraceutical | 1982 | 2019 | 18.6 | low | 0 | 1 | 1 | 9 | 4 | 0 |
| genistein | | 7-hydroxyisoflavones | antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor | 2005 | 2010 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| erucic acid | | docosenoic acid | | 2010 | 2019 | 9.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| nervonic acid | | tetracosenoic acid | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| genistin | | 7-hydroxyisoflavones 7-O-beta-D-glucoside | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| esculetin | | hydroxycoumarin | antioxidant;
plant metabolite;
ultraviolet filter | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| costunolide | | germacranolide;
heterobicyclic compound | anthelminthic drug;
antiinfective agent;
antineoplastic agent;
antiparasitic agent;
antiviral drug;
metabolite | 2005 | 2012 | 15.5 | medium | 0 | 0 | 0 | 1 | 1 | 0 |
| baicalein | | trihydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hormone antagonist;
plant metabolite;
prostaglandin antagonist;
radical scavenger | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| chrysin | | 7-hydroxyflavonol;
dihydroxyflavone | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
hepatoprotective agent;
plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| galangin | | 7-hydroxyflavonol;
trihydroxyflavone | antimicrobial agent;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| morusin | | extended flavonoid;
trihydroxyflavone | antineoplastic agent;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| patuletin | | flavonols;
monomethoxyflavone;
pentahydroxyflavone | analgesic;
antioxidant;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
lipoxygenase inhibitor;
metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| wogonin | | dihydroxyflavone;
monomethoxyflavone | angiogenesis inhibitor;
antineoplastic agent;
cyclooxygenase 2 inhibitor;
plant metabolite | 2005 | 2012 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| daidzein | | 7-hydroxyisoflavones | antineoplastic agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
phytoestrogen;
plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Pinosylvin methyl ether | | stilbenoid | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| caffeic acid phenethyl ester | | alkyl caffeate ester | anti-inflammatory agent;
antibacterial agent;
antineoplastic agent;
antioxidant;
antiviral agent;
immunomodulator;
metabolite;
neuroprotective agent | 2005 | 2020 | 11.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| rosmarinic acid | | rosmarinic acid | geroprotector;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ginkgolic acid | | hydroxybenzoic acid | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| prostaglandin a1 | | prostaglandins A | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| anandamide | | endocannabinoid;
N-acylethanolamine 20:4 | human blood serum metabolite;
neurotransmitter;
vasodilator agent | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| rhoifolin | | dihydroxyflavone;
glycosyloxyflavone;
neohesperidoside | metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| gemeprost | | aliphatic alcohol | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| homo-gamma-linolenylethanolamide | | N-acylethanolamine 20:3 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pitavastatin | | cyclopropanes;
dihydroxy monocarboxylic acid;
monofluorobenzenes;
quinolines;
statin (synthetic) | antioxidant | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| oleylamide | | primary fatty amide | human metabolite;
plant metabolite | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| linoleoyl ethanolamide | | N-acylethanolamine 18:2 | EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoylethanolamine | | endocannabinoid;
N-acylethanolamine 22:6 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n-oleoylethanolamine | | endocannabinoid;
N-(long-chain-acyl)ethanolamine;
N-acylethanolamine 18:1 | EC 3.5.1.23 (ceramidase) inhibitor;
geroprotector;
PPARalpha agonist | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| topiramate | | cyclic ketal;
ketohexose derivative;
sulfamate ester | anticonvulsant;
sodium channel blocker | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| lysophosphatidylcholines | | 1-O-acyl-sn-glycero-3-phosphocholine | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 11,14,17-eicosatrienoate | | fatty acid 20:3;
omega-3 fatty acid | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| bisdemethoxycurcumin | | beta-diketone;
diarylheptanoid;
enone;
polyphenol | EC 3.2.1.1 (alpha-amylase) inhibitor;
metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| syringin | | beta-D-glucoside;
dimethoxybenzene;
monosaccharide derivative;
primary alcohol | hepatoprotective agent;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| MeJA | | Jasmonate derivatives | | 2020 | 2020 | 4.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| methyl linolenate | | fatty acid methyl ester | insect attractant;
plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| osthenol | | hydroxycoumarin | antifungal agent;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| angiotensin amide | | | | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| tazettine | | indole alkaloid fundamental parent;
indole alkaloid | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| furazolidone | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ag 30 | | | | 2014 | 2014 | 10.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| 5-hydroxy-3,3',4',7-tetramethoxyflavone | | 3'-methoxyflavones;
monohydroxyflavone;
tetramethoxyflavone | plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| oleoylanilide | | anilide;
fatty amide | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methyl oleate | | fatty acid methyl ester | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| zr-512 | | ethyl ester;
farnesane sesquiterpenoid | juvenile hormone mimic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ajoene | | sulfoxide | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| gamma-mangostin | | phenols;
xanthones | antineoplastic agent;
plant metabolite;
protein kinase inhibitor | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| narcissin flavonol | | disaccharide derivative;
glycosyloxyflavone;
monomethoxyflavone;
trihydroxyflavone | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| myricetin 3-o-glucuronide | | monosaccharide derivative;
myricetin O-glucuronide;
pentahydroxyflavone | metabolite | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| docosapentaenoic acid | | docosapentaenoic acid;
omega-3 fatty acid | algal metabolite;
human metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| monorden | | cyclic ketone;
enone;
epoxide;
macrolide antibiotic;
monochlorobenzenes;
phenols | antifungal agent;
metabolite;
tyrosine kinase inhibitor | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| linoleamide | | primary fatty amide | human metabolite | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| columbianadin | | alpha,beta-unsaturated carboxylic ester;
furanocoumarin | anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
hepatoprotective agent;
plant metabolite;
rat metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| eicosa-11,14-dienoic acid, (z,z)-isomer | | icosadienoic acid | metabolite | 1998 | 1998 | 26.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| (2E,4E)-N-isobutyl-2,4-dodecadienamide | | fatty amide | metabolite | 2009 | 2009 | 15.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| 4,7,10,13,16,19-docosahexaenoic acid dopamine conjugate | | | | 2019 | 2019 | 5.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| alpha-cyperone | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| stigmasterol 3-o-beta-d-glucopyranoside | | beta-D-glucoside;
monosaccharide derivative;
phytosterols;
steroid saponin | metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nidroxyzone | | C-nitro compound;
furans | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| azimilide | | imidazolidine-2,4-dione | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fr236924 | | | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| hirsutanonol | | | | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| gw9508 | | aromatic amine | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| gw1100 | | | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| scopolamine hydrobromide | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| oregonin | | diarylheptanoid | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bms 309403 | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| quercetin | | | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| buparlisib | | aminopyridine;
aminopyrimidine;
morpholines;
organofluorine compound | antineoplastic agent;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tak-875 | | biphenyls | | 2018 | 2019 | 5.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| catechin | | | | 2010 | 2010 | 14.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| kuraridin | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| gnaphalin | | | | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| phillyrin | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| peoniflorin | | | | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| dinaciclib | | pyrazolopyrimidine | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ascorbic acid | | ascorbic acid;
vitamin C | coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent | 2007 | 2010 | 16.0 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| imidacloprid | | imidacloprid;
imidazolidines;
monochloropyridine | environmental contaminant;
genotoxin;
neonicotinoid insectide;
nicotinic acetylcholine receptor agonist;
xenobiotic | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| rifampin | | cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion | angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae.Journal of agricultural and food chemistry, , Sep-14, Volume: 59, Issue:17, 2011
Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae.Journal of agricultural and food chemistry, , Sep-14, Volume: 59, Issue:17, 2011
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Journal of natural products, , Jul-23, Volume: 73, Issue:7, 2010
Quantitative structure-inhibitory activity relationships of phenols and fatty acids for Bacillus subtilis spore germination.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae.Journal of agricultural and food chemistry, , Sep-14, Volume: 59, Issue:17, 2011
Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita.Journal of agricultural and food chemistry, , Nov-21, Volume: 60, Issue:46, 2012
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Journal of natural products, , Jul-23, Volume: 73, Issue:7, 2010
Quantitative structure-inhibitory activity relationships of phenols and fatty acids for Bacillus subtilis spore germination.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.Journal of medicinal chemistry, , 06-13, Volume: 62, Issue:11, 2019
Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway.The Journal of biological chemistry, , May-23, Volume: 289, Issue:21, 2014
Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita.Journal of agricultural and food chemistry, , Nov-21, Volume: 60, Issue:46, 2012
Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis.Bioorganic & medicinal chemistry, , Apr-15, Volume: 20, Issue:8, 2012
Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae.Journal of agricultural and food chemistry, , Sep-14, Volume: 59, Issue:17, 2011
Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:1, 2008
Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay.Journal of natural products, , Volume: 69, Issue:4, 2006
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.Nature, , Mar-13, Volume: 422, Issue:6928, 2003
A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.Biochemical and biophysical research communications, , Feb-07, Volume: 301, Issue:2, 2003
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.The Journal of biological chemistry, , Mar-28, Volume: 278, Issue:13, 2003
Cox-2 inhibitory effects of naturally occurring and modified fatty acids.Journal of natural products, , Volume: 64, Issue:6, 2001
Quantitative structure-inhibitory activity relationships of phenols and fatty acids for Bacillus subtilis spore germination.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis.Bioorganic & medicinal chemistry, , Apr-15, Volume: 20, Issue:8, 2012
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.Bioorganic & medicinal chemistry letters, , Aug-18, Volume: 13, Issue:16, 2003
Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita.Journal of agricultural and food chemistry, , Nov-21, Volume: 60, Issue:46, 2012
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Journal of natural products, , Jul-23, Volume: 73, Issue:7, 2010
Quantitative structure-inhibitory activity relationships of phenols and fatty acids for Bacillus subtilis spore germination.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.The Journal of biological chemistry, , Sep-15, Volume: 275, Issue:37, 2000
Overview of AKR1C3: Inhibitor Achievements and Disease Insights.Journal of medicinal chemistry, , 10-22, Volume: 63, Issue:20, 2020
Expanding the ChemGPS chemical space with natural products.Journal of natural products, , Volume: 68, Issue:7, 2005
Cox-2 inhibitory effects of naturally occurring and modified fatty acids.Journal of natural products, , Volume: 64, Issue:6, 2001
Binding of prostaglandins to human PPARgamma: tool assessment and new natural ligands.European journal of pharmacology, , Apr-06, Volume: 417, Issue:1-2, 2001
Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita.Journal of agricultural and food chemistry, , Nov-21, Volume: 60, Issue:46, 2012
Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response.Bioorganic & medicinal chemistry, , Oct-01, Volume: 19, Issue:19, 2011
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Journal of natural products, , Jul-23, Volume: 73, Issue:7, 2010
Quantitative structure-inhibitory activity relationships of phenols and fatty acids for Bacillus subtilis spore germination.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis.Bioorganic & medicinal chemistry, , Apr-15, Volume: 20, Issue:8, 2012
Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response.Bioorganic & medicinal chemistry, , Oct-01, Volume: 19, Issue:19, 2011
Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae.Journal of agricultural and food chemistry, , Sep-14, Volume: 59, Issue:17, 2011
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Journal of natural products, , Jul-23, Volume: 73, Issue:7, 2010
Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:1, 2008
Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay.Journal of natural products, , Volume: 69, Issue:4, 2006
Cox-2 inhibitory effects of naturally occurring and modified fatty acids.Journal of natural products, , Volume: 64, Issue:6, 2001
Quantitative structure-inhibitory activity relationships of phenols and fatty acids for Bacillus subtilis spore germination.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Journal of natural products, , Jul-23, Volume: 73, Issue:7, 2010
Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita.Journal of agricultural and food chemistry, , Nov-21, Volume: 60, Issue:46, 2012
Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response.Bioorganic & medicinal chemistry, , Oct-01, Volume: 19, Issue:19, 2011
Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita.Journal of agricultural and food chemistry, , Nov-21, Volume: 60, Issue:46, 2012
Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae.Journal of agricultural and food chemistry, , Sep-14, Volume: 59, Issue:17, 2011
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Journal of natural products, , Jul-23, Volume: 73, Issue:7, 2010
Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay.Journal of natural products, , Volume: 69, Issue:4, 2006
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.Nature, , Mar-13, Volume: 422, Issue:6928, 2003
A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.Biochemical and biophysical research communications, , Feb-07, Volume: 301, Issue:2, 2003
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.The Journal of biological chemistry, , Mar-28, Volume: 278, Issue:13, 2003
Cox-2 inhibitory effects of naturally occurring and modified fatty acids.Journal of natural products, , Volume: 64, Issue:6, 2001
Quantitative structure-inhibitory activity relationships of phenols and fatty acids for Bacillus subtilis spore germination.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Journal of natural products, , Jul-23, Volume: 73, Issue:7, 2010
Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E.Proceedings of the National Academy of Sciences of the United States of America, , Nov-20, Volume: 104, Issue:47, 2007
Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:6, 2007
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Journal of natural products, , Jul-23, Volume: 73, Issue:7, 2010
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.Bioorganic & medicinal chemistry letters, , Aug-18, Volume: 13, Issue:16, 2003
Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration.Journal of medicinal chemistry, , 07-28, Volume: 65, Issue:14, 2022
Structure-Activity Relationships of Fish Oil Derivatives with Antiallergic Activity in Vitro and in Vivo.Journal of medicinal chemistry, , 11-14, Volume: 62, Issue:21, 2019
Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway.The Journal of biological chemistry, , May-23, Volume: 289, Issue:21, 2014
Kinetic isotope effects in the oxidation of arachidonic acid by soybean lipoxygenase-1.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 18, Issue:22, 2008
Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:1, 2008
Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E.Proceedings of the National Academy of Sciences of the United States of America, , Nov-20, Volume: 104, Issue:47, 2007
Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:6, 2007
Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay.Journal of natural products, , Volume: 69, Issue:4, 2006
The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.The Journal of biological chemistry, , Sep-15, Volume: 275, Issue:37, 2000
Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.Journal of natural products, , Volume: 61, Issue:11, 1998
Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration.Journal of medicinal chemistry, , 07-28, Volume: 65, Issue:14, 2022
Structure-Activity Relationships of Fish Oil Derivatives with Antiallergic Activity in Vitro and in Vivo.Journal of medicinal chemistry, , 11-14, Volume: 62, Issue:21, 2019
Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.Journal of medicinal chemistry, , 06-13, Volume: 62, Issue:11, 2019
Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response.Bioorganic & medicinal chemistry, , Oct-01, Volume: 19, Issue:19, 2011
Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:6, 2007
Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay.Journal of natural products, , Volume: 69, Issue:4, 2006
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.Nature, , Mar-13, Volume: 422, Issue:6928, 2003
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.The Journal of biological chemistry, , Mar-28, Volume: 278, Issue:13, 2003
Cox-2 inhibitory effects of naturally occurring and modified fatty acids.Journal of natural products, , Volume: 64, Issue:6, 2001
Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.The Journal of biological chemistry, , Sep-15, Volume: 275, Issue:37, 2000
Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway.The Journal of biological chemistry, , May-23, Volume: 289, Issue:21, 2014
Activation of PPARgamma by metabolites from the flowers of purple coneflower (Echinacea purpurea).Journal of natural products, , May-22, Volume: 72, Issue:5, 2009
Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.Journal of natural products, , Volume: 61, Issue:11, 1998
Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration.Journal of medicinal chemistry, , 07-28, Volume: 65, Issue:14, 2022
Structure-Activity Relationships of Fish Oil Derivatives with Antiallergic Activity in Vitro and in Vivo.Journal of medicinal chemistry, , 11-14, Volume: 62, Issue:21, 2019
Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.Journal of medicinal chemistry, , 06-13, Volume: 62, Issue:11, 2019
The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Potential antagonistic effects of nine natural fatty acids against Meloidogyne incognita.Journal of agricultural and food chemistry, , Nov-21, Volume: 60, Issue:46, 2012
Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis.Bioorganic & medicinal chemistry, , Apr-15, Volume: 20, Issue:8, 2012
Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response.Bioorganic & medicinal chemistry, , Oct-01, Volume: 19, Issue:19, 2011
Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae.Journal of agricultural and food chemistry, , Sep-14, Volume: 59, Issue:17, 2011
Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1.Bioorganic & medicinal chemistry, , Sep-15, Volume: 17, Issue:18, 2009
Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:1, 2008
Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E.Proceedings of the National Academy of Sciences of the United States of America, , Nov-20, Volume: 104, Issue:47, 2007
Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay.Journal of natural products, , Volume: 69, Issue:4, 2006
Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas.Bioorganic & medicinal chemistry letters, , Aug-16, Volume: 14, Issue:16, 2004
The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.Nature, , Mar-13, Volume: 422, Issue:6928, 2003
A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.Biochemical and biophysical research communications, , Feb-07, Volume: 301, Issue:2, 2003
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.The Journal of biological chemistry, , Mar-28, Volume: 278, Issue:13, 2003
Cox-2 inhibitory effects of naturally occurring and modified fatty acids.Journal of natural products, , Volume: 64, Issue:6, 2001
Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.Journal of natural products, , Volume: 61, Issue:11, 1998
Quantitative structure-inhibitory activity relationships of phenols and fatty acids for Bacillus subtilis spore germination.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Journal of natural products, , Jul-23, Volume: 73, Issue:7, 2010
Structure-Activity Relationships of Fish Oil Derivatives with Antiallergic Activity in Vitro and in Vivo.Journal of medicinal chemistry, , 11-14, Volume: 62, Issue:21, 2019
Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response.Bioorganic & medicinal chemistry, , Oct-01, Volume: 19, Issue:19, 2011
Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:6, 2007
Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay.Journal of natural products, , Volume: 69, Issue:4, 2006
Cox-2 inhibitory effects of naturally occurring and modified fatty acids.Journal of natural products, , Volume: 64, Issue:6, 2001
Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.Journal of natural products, , Volume: 61, Issue:11, 1998
Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Journal of natural products, , Jul-23, Volume: 73, Issue:7, 2010
Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 21, Issue:22, 2011
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Journal of natural products, , Jul-23, Volume: 73, Issue:7, 2010
Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae.Journal of agricultural and food chemistry, , Sep-14, Volume: 59, Issue:17, 2011
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Journal of natural products, , Jul-23, Volume: 73, Issue:7, 2010
Expanding the ChemGPS chemical space with natural products.Journal of natural products, , Volume: 68, Issue:7, 2005
Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae.Journal of agricultural and food chemistry, , Sep-14, Volume: 59, Issue:17, 2011
Structure-Activity Relationships of Fish Oil Derivatives with Antiallergic Activity in Vitro and in Vivo.Journal of medicinal chemistry, , 11-14, Volume: 62, Issue:21, 2019
Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis.Bioorganic & medicinal chemistry, , Apr-15, Volume: 20, Issue:8, 2012
Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response.Bioorganic & medicinal chemistry, , Oct-01, Volume: 19, Issue:19, 2011
Activation of PPARgamma by metabolites from the flowers of purple coneflower (Echinacea purpurea).Journal of natural products, , May-22, Volume: 72, Issue:5, 2009
Phytotoxic Eremophilanes from Ligularia macrophylla.Journal of agricultural and food chemistry, , Dec-26, Volume: 55, Issue:26, 2007
Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E.Proceedings of the National Academy of Sciences of the United States of America, , Nov-20, Volume: 104, Issue:47, 2007
Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay.Journal of natural products, , Volume: 69, Issue:4, 2006
The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.Nature, , Mar-13, Volume: 422, Issue:6928, 2003
A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.Biochemical and biophysical research communications, , Feb-07, Volume: 301, Issue:2, 2003
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.The Journal of biological chemistry, , Mar-28, Volume: 278, Issue:13, 2003
Cox-2 inhibitory effects of naturally occurring and modified fatty acids.Journal of natural products, , Volume: 64, Issue:6, 2001
Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.Journal of natural products, , Volume: 61, Issue:11, 1998
Quantitative structure-inhibitory activity relationships of phenols and fatty acids for Bacillus subtilis spore germination.Journal of medicinal chemistry, , Volume: 25, Issue:3, 1982
Structure-Activity Relationships of Fish Oil Derivatives with Antiallergic Activity in Vitro and in Vivo.Journal of medicinal chemistry, , 11-14, Volume: 62, Issue:21, 2019
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Journal of natural products, , Jul-23, Volume: 73, Issue:7, 2010
Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.The Journal of biological chemistry, , Sep-15, Volume: 275, Issue:37, 2000
Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 29, Issue:6, 2019
Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles.Bioorganic & medicinal chemistry, , 12-01, Volume: 26, Issue:22, 2018
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.Journal of natural products, , Jul-23, Volume: 73, Issue:7, 2010
Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E.Proceedings of the National Academy of Sciences of the United States of America, , Nov-20, Volume: 104, Issue:47, 2007
Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:6, 2007
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| dinitrochlorobenzene | | C-nitro compound;
monochlorobenzenes | allergen;
epitope;
sensitiser | 1999 | 2006 | 21.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| protocatechuic acid | | catechols;
dihydroxybenzoic acid | antineoplastic agent;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor;
human xenobiotic metabolite;
plant metabolite | 1999 | 2015 | 18.7 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| 3-chloroalanine | | chloroalanine;
non-proteinogenic alpha-amino acid;
organochlorine compound | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| acetoacetic acid | | 3-oxo fatty acid;
ketone body | metabolite | 1964 | 2008 | 38.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| gamma-aminobutyric acid | | amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid | human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule | 1996 | 2023 | 15.2 | low | 0 | 0 | 2 | 1 | 2 | 1 |
| 4-hydroxybenzoic acid | | monohydroxybenzoic acid | algal metabolite;
plant metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| aminolevulinic acid | | 4-oxo monocarboxylic acid;
amino acid zwitterion;
delta-amino acid | antineoplastic agent;
dermatologic drug;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite;
prodrug;
Saccharomyces cerevisiae metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 5-hydroxytryptophan | | hydroxytryptophan | human metabolite;
neurotransmitter | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ethylene glycol | | ethanediol;
glycol | metabolite;
mouse metabolite;
solvent;
toxin | 1988 | 2004 | 26.0 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| acetic acid | | monocarboxylic acid | antimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent | 1985 | 2021 | 22.2 | low | 0 | 3 | 0 | 4 | 2 | 1 |
| acetaldehyde | | aldehyde | carcinogenic agent;
EC 3.5.1.4 (amidase) inhibitor;
electron acceptor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
mutagen;
oxidising agent;
Saccharomyces cerevisiae metabolite;
teratogenic agent | 1990 | 2014 | 21.0 | low | 0 | 0 | 2 | 2 | 1 | 0 |
| acetone | | ketone body;
methyl ketone;
propanones;
volatile organic compound | EC 3.5.1.4 (amidase) inhibitor;
human metabolite;
polar aprotic solvent | 1993 | 2022 | 16.3 | low | 0 | 0 | 4 | 4 | 6 | 1 |
| adenine | | 6-aminopurines;
purine nucleobase | Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1963 | 2017 | 26.8 | low | 0 | 1 | 2 | 0 | 2 | 0 |
| adipic acid | | alpha,omega-dicarboxylic acid;
dicarboxylic fatty acid | food acidity regulator;
human xenobiotic metabolite | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| agmatine | | guanidines;
primary amino compound | Escherichia coli metabolite;
mouse metabolite | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ammonium hydroxide | | azane;
gas molecular entity;
mononuclear parent hydride | EC 3.5.1.4 (amidase) inhibitor;
metabolite;
mouse metabolite;
neurotoxin;
NMR chemical shift reference compound;
nucleophilic reagent;
refrigerant | 2004 | 2008 | 18.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| quinacrine | | acridines;
aromatic ether;
organochlorine compound;
tertiary amino compound | antimalarial;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor | 1988 | 1999 | 30.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| beta-alanine | | amino acid zwitterion;
beta-amino acid | agonist;
fundamental metabolite;
human metabolite;
inhibitor;
neurotransmitter | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| benzaldehyde | | benzaldehydes | EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
EC 3.5.5.1 (nitrilase) inhibitor;
flavouring agent;
fragrance;
odorant receptor agonist;
plant metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzene | | aromatic annulene;
benzenes;
volatile organic compound | carcinogenic agent;
environmental contaminant;
non-polar solvent | 2004 | 2019 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| benzoic acid | | benzoic acids | algal metabolite;
antimicrobial food preservative;
drug allergen;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
human xenobiotic metabolite;
plant metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzyl alcohol | | benzyl alcohols | antioxidant;
fragrance;
metabolite;
solvent | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| betaine | | amino-acid betaine;
glycine derivative | fundamental metabolite | 1998 | 2005 | 22.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| 1-butanol | | alkyl alcohol;
primary alcohol;
short-chain primary fatty alcohol | human metabolite;
mouse metabolite;
protic solvent | 1999 | 2023 | 11.4 | low | 0 | 0 | 1 | 1 | 2 | 1 |
| butyric acid | | fatty acid 4:0;
straight-chain saturated fatty acid | human urinary metabolite;
Mycoplasma genitalium metabolite | 1988 | 2022 | 18.8 | low | 0 | 1 | 2 | 0 | 1 | 1 |
| carbamates | | amino-acid anion | | 2000 | 2010 | 19.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| carbon monoxide | | carbon oxide;
gas molecular entity;
one-carbon compound | biomarker;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
human metabolite;
ligand;
metabolite;
mitochondrial respiratory-chain inhibitor;
mouse metabolite;
neurotoxin;
neurotransmitter;
P450 inhibitor;
probe;
signalling molecule;
vasodilator agent | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| formic acid | | monocarboxylic acid | antibacterial agent;
astringent;
metabolite;
protic solvent;
solvent | 1997 | 2016 | 17.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| carnitine | | amino-acid betaine | human metabolite;
mouse metabolite | 1981 | 2022 | 22.9 | low | 0 | 3 | 3 | 3 | 1 | 1 |
| catechol | | catechols | allelochemical;
genotoxin;
plant metabolite | 1963 | 2001 | 42.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| methane | | alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound | bacterial metabolite;
fossil fuel;
greenhouse gas | 1964 | 2023 | 20.3 | low | 1 | 2 | 1 | 2 | 4 | 1 |
| choline | | cholines | allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1963 | 2020 | 33.8 | low | 0 | 6 | 1 | 0 | 3 | 0 |
| citric acid, anhydrous | | tricarboxylic acid | antimicrobial agent;
chelator;
food acidity regulator;
fundamental metabolite | 2002 | 2022 | 12.0 | low | 0 | 0 | 0 | 5 | 2 | 2 |
| chlorine | | halide anion;
monoatomic chlorine | cofactor;
Escherichia coli metabolite;
human metabolite | 1985 | 2001 | 31.5 | low | 0 | 1 | 2 | 1 | 0 | 0 |
| hydrochloric acid | | chlorine molecular entity;
gas molecular entity;
hydrogen halide;
mononuclear parent hydride | mouse metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| salicylic acid | | monohydroxybenzoic acid | algal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite | 2000 | 2022 | 12.2 | low | 1 | 0 | 1 | 3 | 3 | 1 |
| salicylic acid | | monohydroxybenzoic acid | algal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite | 1982 | 2022 | 15.6 | low | 1 | 1 | 1 | 3 | 3 | 1 |
| octane | | alkane | xenobiotic | 1996 | 1998 | 27.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| phloroglucinol | | benzenetriol;
phenolic donor | algal metabolite | 2007 | 2012 | 14.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| gallic acid | | trihydroxybenzoic acid | antineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite | 2002 | 2020 | 13.2 | low | 0 | 0 | 0 | 6 | 8 | 0 |
| octanoic acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | antibacterial agent;
Escherichia coli metabolite;
human metabolite | 1986 | 2014 | 21.6 | low | 0 | 2 | 4 | 6 | 5 | 0 |
| dihydrolipoic acid | | thio-fatty acid | antioxidant;
human metabolite;
neuroprotective agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-hydroxybutyric acid | | (omega-1)-hydroxy fatty acid;
3-hydroxy monocarboxylic acid;
hydroxybutyric acid | human metabolite | 1998 | 2021 | 14.0 | low | 0 | 0 | 2 | 4 | 4 | 2 |
| guaiacol | | guaiacols | disinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| methylmalonic acid | | C4-dicarboxylic acid | human metabolite | 1985 | 1997 | 33.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| malic acid | | 2-hydroxydicarboxylic acid;
C4-dicarboxylic acid | food acidity regulator;
fundamental metabolite | 2008 | 2017 | 11.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| 3,4-dihydroxyphenylacetic acid | | catechols;
dihydroxyphenylacetic acid | human metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fosmidomycin | | hydroxamic acid;
phosphonic acids | antimicrobial agent;
bacterial metabolite;
EC 1.1.1.267 (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibitor | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| creatine | | glycine derivative;
guanidines;
zwitterion | geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent;
nutraceutical | 2007 | 2018 | 11.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| lactic acid | | 2-hydroxy monocarboxylic acid | algal metabolite;
Daphnia magna metabolite | 1982 | 2020 | 18.7 | low | 0 | 2 | 2 | 6 | 5 | 0 |
| diacetyl | | alpha-diketone | Escherichia coli metabolite;
Saccharomyces cerevisiae metabolite | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dimethyl sulfoxide | | sulfoxide;
volatile organic compound | alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger | 1985 | 2022 | 20.3 | low | 0 | 1 | 4 | 1 | 2 | 1 |
| ethanolamine | | ethanolamines;
primary alcohol;
primary amine | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 1964 | 1998 | 39.8 | low | 0 | 3 | 1 | 0 | 0 | 0 |
| formaldehyde | | aldehyde;
one-carbon compound | allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1990 | 2000 | 29.0 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| glycine | | alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid | EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical | 1995 | 2022 | 12.5 | low | 0 | 0 | 1 | 2 | 1 | 2 |
| glycerol | | alditol;
triol | algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent | 1964 | 2023 | 23.6 | low | 3 | 10 | 6 | 10 | 8 | 4 |
| glycerol | | alditol;
triol | algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent | 1964 | 2023 | 23.2 | low | 3 | 10 | 6 | 10 | 9 | 4 |
| alpha-glycerophosphoric acid | | glycerol monophosphate | algal metabolite;
human metabolite | 1984 | 1990 | 36.7 | low | 0 | 2 | 1 | 0 | 0 | 0 |
| glycolic acid | | 2-hydroxy monocarboxylic acid;
primary alcohol | keratolytic drug;
metabolite | 2017 | 2017 | 7.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| hydrogen carbonate | | carbon oxoanion | cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1964 | 1983 | 50.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| histamine | | aralkylamino compound;
imidazoles | human metabolite;
mouse metabolite;
neurotransmitter | 1987 | 2001 | 31.0 | low | 1 | 1 | 2 | 1 | 0 | 0 |
| thiocyanic acid | | hydracid;
one-carbon compound;
organosulfur compound | Escherichia coli metabolite | 2001 | 2002 | 22.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| hydrogen | | elemental hydrogen;
elemental molecule;
gas molecular entity | antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite | 1993 | 2020 | 16.7 | low | 0 | 0 | 5 | 9 | 8 | 0 |
| hydroquinone | | benzenediol;
hydroquinones | antioxidant;
carcinogenic agent;
cofactor;
Escherichia coli metabolite;
human xenobiotic metabolite;
mouse metabolite;
skin lightening agent | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| imidazole | | imidazole | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| indole | | indole;
polycyclic heteroarene | Escherichia coli metabolite | 2014 | 2015 | 9.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| indoleacetic acid | | indole-3-acetic acids;
monocarboxylic acid | auxin;
human metabolite;
mouse metabolite;
plant hormone;
plant metabolite | 2000 | 2017 | 16.0 | low | 1 | 0 | 2 | 0 | 2 | 0 |
| iodine | | diatomic iodine | nutrient | 1984 | 2022 | 19.0 | low | 0 | 1 | 0 | 4 | 0 | 1 |
| dihydroxyphenylalanine | | hydroxyphenylalanine;
non-proteinogenic alpha-amino acid;
tyrosine derivative | human metabolite | 1989 | 1998 | 30.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| kynurenine | | aromatic ketone;
non-proteinogenic alpha-amino acid;
substituted aniline | human metabolite | 2018 | 2022 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| lipoamide | | dithiolanes;
monocarboxylic acid amide | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2015 | 2020 | 6.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| thioctic acid | | dithiolanes;
heterocyclic fatty acid;
thia fatty acid | fundamental metabolite;
geroprotector | 2003 | 2011 | 18.2 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| methanol | | alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound | amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite | 1984 | 2022 | 18.6 | low | 0 | 1 | 8 | 15 | 7 | 1 |
| methanol | | alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound | amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite | 1984 | 2023 | 17.9 | low | 0 | 1 | 8 | 16 | 8 | 2 |
| phytic acid | | inositol phosphate | | 2003 | 2017 | 12.2 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| inositol | | cyclitol;
hexol | | 1965 | 2005 | 33.5 | low | 0 | 1 | 2 | 1 | 0 | 0 |
| melatonin | | acetamides;
tryptamines | anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger | 1999 | 2021 | 18.9 | low | 0 | 0 | 4 | 12 | 1 | 1 |
| croton oil | | N-acyl-hexosamine | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| naphthalene | | naphthalenes;
ortho-fused bicyclic arene | apoptosis inhibitor;
carcinogenic agent;
environmental contaminant;
mouse metabolite;
plant metabolite;
volatile oil component | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nickel | | metal allergen;
nickel group element atom | epitope;
micronutrient | 2003 | 2022 | 11.6 | low | 0 | 0 | 0 | 3 | 1 | 1 |
| niacinamide | | pyridine alkaloid;
pyridinecarboxamide;
vitamin B3 | anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor | 1964 | 2023 | 21.0 | low | 2 | 1 | 1 | 0 | 1 | 2 |
| niacin | | pyridine alkaloid;
pyridinemonocarboxylic acid;
vitamin B3 | antidote;
antilipemic drug;
EC 3.5.1.19 (nicotinamidase) inhibitor;
Escherichia coli metabolite;
human urinary metabolite;
metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent | 1963 | 2014 | 35.2 | low | 0 | 4 | 2 | 1 | 2 | 0 |
| niacin | | pyridine alkaloid;
pyridinemonocarboxylic acid;
vitamin B3 | antidote;
antilipemic drug;
EC 3.5.1.19 (nicotinamidase) inhibitor;
Escherichia coli metabolite;
human urinary metabolite;
metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent | 1963 | 2014 | 34.8 | low | 0 | 4 | 3 | 1 | 2 | 0 |
| nitrates | | monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species | | 1999 | 2020 | 14.2 | low | 0 | 0 | 1 | 1 | 3 | 0 |
| nitroxyl | | nitrogen oxoacid | | 2005 | 2007 | 18.0 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| nitrites | | monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species | human metabolite | 2000 | 2015 | 17.2 | low | 0 | 0 | 1 | 2 | 2 | 0 |
| hydroxide ion | | oxygen hydride | mouse metabolite | 1999 | 2011 | 19.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| orotic acid | | pyrimidinemonocarboxylic acid | Escherichia coli metabolite;
metabolite;
mouse metabolite | 1963 | 2004 | 40.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| oxaloacetic acid | | C4-dicarboxylic acid;
oxo dicarboxylic acid | geroprotector;
metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-aminobenzoic acid | | aminobenzoic acid;
aromatic amino-acid zwitterion | allergen;
Escherichia coli metabolite;
plant metabolite | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| palmitic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor;
plant metabolite | 1962 | 2023 | 27.7 | low | 14 | 140 | 121 | 108 | 120 | 15 |
| phenanthrene | | ortho-fused polycyclic arene;
ortho-fused tricyclic hydrocarbon;
phenanthrenes | environmental contaminant;
mouse metabolite | 1998 | 2002 | 24.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| phenol | | phenols | antiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite | 2005 | 2020 | 13.1 | low | 0 | 0 | 0 | 7 | 4 | 0 |
| phenylpyruvic acid | | 2-oxo monocarboxylic acid | chromogenic compound;
EC 6.4.1.1 (pyruvate carboxylase) inhibitor;
fundamental metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| phenylacetaldehyde | | alpha-CH2-containing aldehyde;
phenylacetaldehydes | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2008 | 2014 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| phenethylamine | | alkaloid;
aralkylamine;
phenylethylamine | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phosphorylcholine | | phosphocholines | allergen;
epitope;
hapten;
human metabolite;
mouse metabolite | 2001 | 2008 | 20.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| pqq cofactor | | orthoquinones;
pyrroloquinoline cofactor;
tricarboxylic acid | anti-inflammatory agent;
antioxidant;
cofactor;
water-soluble vitamin (role) | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| propylene glycol | | glycol;
propane-1,2-diols | allergen;
human xenobiotic metabolite;
mouse metabolite;
protic solvent | 2003 | 2009 | 18.7 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| 1-propanol | | propan-1-ols;
short-chain primary fatty alcohol | metabolite;
protic solvent | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| propionic acid | | saturated fatty acid;
short-chain fatty acid | antifungal drug | 2002 | 2016 | 17.5 | low | 1 | 0 | 0 | 3 | 1 | 0 |
| pteridines | | azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
pteridines | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| purine | | purine | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| putrescine | | alkane-alpha,omega-diamine | antioxidant;
fundamental metabolite | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| pyridine | | azaarene;
mancude organic heteromonocyclic parent;
monocyclic heteroarene;
pyridines | environmental contaminant;
NMR chemical shift reference compound | 1997 | 2018 | 15.7 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| pyridoxal phosphate | | methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6 phosphate | coenzyme;
cofactor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1964 | 2010 | 37.0 | low | 1 | 1 | 0 | 1 | 0 | 0 |
| pyridoxamine | | aminoalkylpyridine;
hydroxymethylpyridine;
monohydroxypyridine;
vitamin B6 | Escherichia coli metabolite;
human metabolite;
iron chelator;
mouse metabolite;
nephroprotective agent;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pyridoxine | | hydroxymethylpyridine;
methylpyridines;
monohydroxypyridine;
vitamin B6 | cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1951 | 2012 | 47.1 | low | 0 | 4 | 1 | 1 | 1 | 0 |
| pyrogallol | | benzenetriol;
phenolic donor | plant metabolite | 1994 | 2001 | 26.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| pyruvic acid | | 2-oxo monocarboxylic acid | cofactor;
fundamental metabolite | 1986 | 2001 | 28.0 | low | 0 | 1 | 2 | 1 | 0 | 0 |
| quinolinic acid | | pyridinedicarboxylic acid | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
NMDA receptor agonist | 2003 | 2007 | 19.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| dithionite | | sulfur oxide;
sulfur oxoanion | | 2002 | 2003 | 21.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| sarcosine | | N-alkylglycine zwitterion;
N-alkylglycine;
N-methyl-amino acid;
N-methylglycines | Escherichia coli metabolite;
glycine receptor agonist;
glycine transporter 1 inhibitor;
human metabolite;
mouse metabolite | 1993 | 2011 | 22.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| selenious acid | | selenium oxoacid | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| sulfites | | divalent inorganic anion;
sulfur oxide;
sulfur oxoanion | | 1990 | 2010 | 23.3 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| spermidine | | polyazaalkane;
triamine | autophagy inducer;
fundamental metabolite;
geroprotector | 1989 | 2012 | 23.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| succinic acid | | alpha,omega-dicarboxylic acid;
C4-dicarboxylic acid | anti-ulcer drug;
fundamental metabolite;
micronutrient;
nutraceutical;
radiation protective agent | 2004 | 2020 | 12.2 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| sulfuric acid | | sulfur oxoacid | catalyst | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| taurine | | amino sulfonic acid;
zwitterion | antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite | 1982 | 2023 | 15.6 | low | 0 | 1 | 1 | 0 | 1 | 2 |
| thiamine | | primary alcohol;
vitamin B1 | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1963 | 2020 | 40.4 | low | 0 | 3 | 0 | 1 | 1 | 0 |
| thymine | | pyrimidine nucleobase;
pyrimidone | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 2000 | 2005 | 21.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| toluene | | methylbenzene;
toluenes;
volatile organic compound | cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| uracil | | pyrimidine nucleobase;
pyrimidone | allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| uric acid | | uric acid | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 1963 | 2020 | 29.2 | low | 0 | 2 | 1 | 2 | 1 | 0 |
| urea | | isourea;
monocarboxylic acid amide;
one-carbon compound | Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1963 | 2016 | 25.5 | low | 0 | 1 | 2 | 1 | 2 | 0 |
| vanillin | | benzaldehydes;
monomethoxybenzene;
phenols | anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite | 2007 | 2018 | 11.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| vanillin | | benzaldehydes;
monomethoxybenzene;
phenols | anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| xanthine | | xanthine | Saccharomyces cerevisiae metabolite | 1991 | 1993 | 31.7 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| 2-amino-5-phosphonovalerate | | non-proteinogenic alpha-amino acid | NMDA receptor antagonist | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| menthol | | p-menthane monoterpenoid;
secondary alcohol | volatile oil component | 2005 | 2010 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| 1,10-phenanthroline | | phenanthroline | EC 2.7.1.1 (hexokinase) inhibitor;
EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 1,2-dimethylhydrazine | | hydrazines | alkylating agent;
carcinogenic agent | 2001 | 2003 | 22.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| 1,2-dioctanoylglycerol | | | | 1994 | 1995 | 29.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| 1-aminobenzotriazole | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1-anilino-8-naphthalenesulfonate | | aminonaphthalene;
naphthalenesulfonic acid | fluorescent probe | 1963 | 2023 | 17.9 | low | 1 | 6 | 14 | 15 | 16 | 10 |
| 1-anilino-8-naphthalenesulfonate | | aminonaphthalene;
naphthalenesulfonic acid | fluorescent probe | 1963 | 2023 | 18.0 | low | 1 | 6 | 14 | 14 | 15 | 10 |
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | | methylpyridines;
phenylpyridine;
tetrahydropyridine | neurotoxin | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| edelfosine | | glycerophosphocholine | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| gw 2433 | | | | 2001 | 2001 | 23.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | | imidazopyridine;
primary amino compound | carcinogenic agent;
mutagen | 1997 | 2021 | 21.7 | low | 0 | 0 | 4 | 5 | 0 | 1 |
| mercaptoethanol | | alkanethiol;
primary alcohol | geroprotector | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pyrithione | | monohydroxypyridine;
pyridinethione | ionophore | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 2-aminoethoxydiphenyl borate | | organoboron compound;
primary amino compound | calcium channel blocker;
IP3 receptor antagonist;
potassium channel opener | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aminopropionitrile | | aminopropionitrile | antineoplastic agent;
antirheumatic drug;
collagen cross-linking inhibitor;
plant metabolite | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 3-methylcholanthrene | | ortho- and peri-fused polycyclic arene | aryl hydrocarbon receptor agonist;
carcinogenic agent | 1998 | 2009 | 20.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| 5,5-dimethyl-1-pyrroline-1-oxide | | 1-pyrroline nitrones | neuroprotective agent;
spin trapping reagent | 2000 | 2020 | 17.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| phenytoin | | imidazolidine-2,4-dione | anticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent | 1986 | 1995 | 33.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| 5,8,11,14-eicosatetraynoic acid | | long-chain fatty acid | | 1986 | 2000 | 31.6 | low | 0 | 2 | 7 | 0 | 0 | 0 |
| 6-methoxytryptoline | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| oxyquinoline | | monohydroxyquinoline | antibacterial agent;
antifungal agrochemical;
antiseptic drug;
iron chelator | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aa 861 | | 1,4-benzoquinones;
acetylenic compound;
primary alcohol | EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
ferroptosis inhibitor | 1994 | 2006 | 22.7 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| 2,2'-azobis(2-amidinopropane) | | monoazo compound | | 1992 | 2012 | 21.9 | low | 0 | 0 | 12 | 16 | 2 | 0 |
| acetohexamide | | acetophenones;
N-sulfonylurea | hypoglycemic agent;
insulin secretagogue | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-(acetylamino)benzeneacetic acid | | acetamides;
anilide | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| adrenic acid | | docosatetraenoic acid | mouse metabolite | 1988 | 2020 | 22.8 | low | 0 | 1 | 1 | 1 | 1 | 0 |
| tocopheroxy radical | | tocopherol | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| alprazolam | | organochlorine compound;
triazolobenzodiazepine | anticonvulsant;
anxiolytic drug;
GABA agonist;
muscle relaxant;
sedative;
xenobiotic | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| am 251 | | amidopiperidine;
carbohydrazide;
dichlorobenzene;
organoiodine compound;
pyrazoles | antidepressant;
antineoplastic agent;
apoptosis inducer;
CB1 receptor antagonist | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ambroxol | | aromatic amine | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ametantrone | | | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| pimagedine | | guanidines;
one-carbon compound | EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 1.4.3.4 (monoamine oxidase) inhibitor | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| p-aminohippuric acid | | N-acylglycine | Daphnia magna metabolite | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| theophylline | | dimethylxanthine | adenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent | 1963 | 2023 | 34.7 | low | 0 | 4 | 2 | 0 | 0 | 1 |
| amitriptyline | | carbotricyclic compound;
tertiary amine | adrenergic uptake inhibitor;
antidepressant;
environmental contaminant;
tropomyosin-related kinase B receptor agonist;
xenobiotic | 2000 | 2019 | 11.3 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| anethole trithione | | methoxybenzenes | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 9-anthroic acid | | anthroic acid | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| aspirin | | benzoic acids;
phenyl acetates;
salicylates | anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent | 1982 | 2022 | 28.7 | low | 2 | 8 | 7 | 1 | 2 | 1 |
| aurintricarboxylic acid | | monohydroxybenzoic acid;
quinomethanes;
tricarboxylic acid | fluorochrome;
histological dye;
insulin-like growth factor receptor 1 antagonist | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| azelaic acid | | alpha,omega-dicarboxylic acid;
dicarboxylic fatty acid | antibacterial agent;
antineoplastic agent;
dermatologic drug;
plant metabolite | 2010 | 2011 | 13.5 | low | 1 | 0 | 0 | 1 | 1 | 0 |
| 2,2-bis(4-glycidyloxyphenyl)propane | | diarylmethane | | 2003 | 2006 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| bay-k-8644 | | (trifluoromethyl)benzenes;
C-nitro compound;
dihydropyridine;
methyl ester | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| benzo(a)pyrene | | ortho- and peri-fused polycyclic arene | carcinogenic agent;
mouse metabolite | 1983 | 2007 | 28.0 | low | 0 | 1 | 3 | 4 | 0 | 0 |
| benzyl benzoate | | benzoate ester;
benzyl ester | acaricide;
plant metabolite;
scabicide | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bepridil | | pyrrolidines;
tertiary amine | anti-arrhythmia drug;
antihypertensive agent;
calcium channel blocker;
vasodilator agent | 1995 | 2002 | 24.5 | low | 0 | 0 | 2 | 2 | 0 | 0 |
| 2,5-di-tert-butylhydroquinone | | hydroquinones | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| bisbenzimidazole | | bibenzimidazole;
N-methylpiperazine | anthelminthic drug;
fluorochrome | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bisindolylmaleimide i | | | | 1997 | 2018 | 17.3 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| bupivacaine | | aromatic amide;
piperidinecarboxamide;
tertiary amino compound | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| caffeine | | purine alkaloid;
trimethylxanthine | adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic | 1994 | 2008 | 21.0 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| verapamil | | aromatic ether;
nitrile;
polyether;
tertiary amino compound | | 1989 | 2016 | 27.6 | low | 0 | 1 | 3 | 0 | 1 | 0 |
| camostat | | benzoate ester;
carboxylic ester;
diester;
guanidines;
tertiary carboxamide | anti-inflammatory agent;
anticoronaviral agent;
antifibrinolytic drug;
antihypertensive agent;
antineoplastic agent;
antiviral agent;
serine protease inhibitor | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| carbamazepine | | dibenzoazepine;
ureas | analgesic;
anticonvulsant;
antimanic drug;
drug allergen;
EC 3.5.1.98 (histone deacetylase) inhibitor;
environmental contaminant;
glutamate transporter activator;
mitogen;
non-narcotic analgesic;
sodium channel blocker;
xenobiotic | 1981 | 2001 | 33.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| carcinine | | beta-alanine derivative;
imidazoles;
monocarboxylic acid amide;
organonitrogen compound;
organooxygen compound | antioxidant;
crustacean metabolite | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| carprofen | | carbazoles;
organochlorine compound | EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-steroidal anti-inflammatory drug;
photosensitizing agent | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| cetyltrimethylammonium ion | | quaternary ammonium ion | | 1992 | 2015 | 23.5 | low | 0 | 0 | 2 | 1 | 1 | 0 |
| chloroquine | | aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound | anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug | 1998 | 2000 | 25.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| chlorothiazide | | benzothiadiazine | antihypertensive agent;
diuretic | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| chlorpromazine | | organochlorine compound;
phenothiazines;
tertiary amine | anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug | 1988 | 2000 | 30.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| ciglitazone | | aromatic ether;
thiazolidinone | antineoplastic agent;
insulin-sensitizing drug | 2001 | 2014 | 14.7 | low | 0 | 0 | 0 | 3 | 3 | 0 |
| eucalyptol | | | | 2009 | 2012 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| ciprofloxacin | | aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion | antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| clofibrate | | aromatic ether;
ethyl ester;
monochlorobenzenes | anticholesteremic drug;
antilipemic drug;
geroprotector;
PPARalpha agonist | 1984 | 2017 | 23.5 | low | 0 | 1 | 2 | 4 | 1 | 0 |
| clofibric acid | | aromatic ether;
monocarboxylic acid;
monochlorobenzenes | anticholesteremic drug;
antilipemic drug;
antineoplastic agent;
herbicide;
marine xenobiotic metabolite;
PPARalpha agonist | 1984 | 1992 | 35.3 | low | 0 | 1 | 2 | 0 | 0 | 0 |
| clonidine | | clonidine;
imidazoline | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| dantrolene | | hydrazone;
imidazolidine-2,4-dione | muscle relaxant;
neuroprotective agent;
ryanodine receptor antagonist | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| decanoic acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
anti-inflammatory agent;
antibacterial agent;
human metabolite;
plant metabolite;
volatile oil component | 1994 | 2017 | 19.8 | low | 0 | 0 | 3 | 5 | 2 | 0 |
| deferiprone | | 4-pyridones | iron chelator;
protective agent | 2019 | 2021 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| deferoxamine | | acyclic desferrioxamine | bacterial metabolite;
ferroptosis inhibitor;
iron chelator;
siderophore | 1989 | 2002 | 26.8 | low | 0 | 1 | 3 | 1 | 0 | 0 |
| diazepam | | 1,4-benzodiazepinone;
organochlorine compound | anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic | 1993 | 2017 | 20.7 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| diclofenac | | amino acid;
aromatic amine;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound | antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ddt | | benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide | bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| pentetic acid | | pentacarboxylic acid | copper chelator | 1989 | 1997 | 31.3 | low | 0 | 1 | 2 | 0 | 0 | 0 |
| benzophenone | | benzophenones | photosensitizing agent;
plant metabolite | 1993 | 2011 | 22.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| dipyridamole | | piperidines;
pyrimidopyrimidine;
tertiary amino compound;
tetrol | adenosine phosphodiesterase inhibitor;
EC 3.5.4.4 (adenosine deaminase) inhibitor;
platelet aggregation inhibitor;
vasodilator agent | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| valproic acid | | branched-chain fatty acid;
branched-chain saturated fatty acid | anticonvulsant;
antimanic drug;
EC 3.5.1.98 (histone deacetylase) inhibitor;
GABA agent;
neuroprotective agent;
psychotropic drug;
teratogenic agent | 1996 | 2005 | 24.3 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| ebselen | | benzoselenazole | anti-inflammatory drug;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 3.5.4.1 (cytosine deaminase) inhibitor;
EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor;
enzyme mimic;
ferroptosis inhibitor;
genotoxin;
hepatoprotective agent;
neuroprotective agent;
radical scavenger | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| econazole | | dichlorobenzene;
ether;
imidazoles;
monochlorobenzenes | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| eicosa-11,14-dienoic acid | | long-chain fatty acid | | 2001 | 2012 | 15.8 | high | 0 | 0 | 0 | 2 | 2 | 0 |
| embelin | | dihydroxy-1,4-benzoquinones | antimicrobial agent;
antineoplastic agent;
hepatitis C protease inhibitor;
plant metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| emodin | | trihydroxyanthraquinone | antineoplastic agent;
laxative;
plant metabolite;
tyrosine kinase inhibitor | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| erythrosine | | | | 1990 | 2005 | 25.0 | low | 0 | 0 | 3 | 2 | 0 | 0 |
| ethacrynic acid | | aromatic ether;
aromatic ketone;
dichlorobenzene;
monocarboxylic acid | EC 2.5.1.18 (glutathione transferase) inhibitor;
ion transport inhibitor;
loop diuretic | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ether | | ether;
volatile organic compound | inhalation anaesthetic;
non-polar solvent;
refrigerant | 1993 | 2019 | 18.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| ethoxyquin | | aromatic ether;
quinolines | antifungal agrochemical;
food antioxidant;
genotoxin;
geroprotector;
herbicide;
Hsp90 inhibitor;
neuroprotective agent;
UDP-glucuronosyltransferase activator | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ethoxyresorufin | | phenoxazine | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| eicosapentaenoic acid ethyl ester | | | | 1998 | 2021 | 9.0 | low | 0 | 0 | 1 | 1 | 3 | 2 |
| carbonyl cyanide p-trifluoromethoxyphenylhydrazone | | aromatic ether;
hydrazone;
nitrile;
organofluorine compound | ATP synthase inhibitor;
geroprotector;
ionophore | 1998 | 2008 | 21.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| fenofibrate | | aromatic ether;
chlorobenzophenone;
isopropyl ester;
monochlorobenzenes | antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic | 1989 | 2018 | 19.6 | low | 0 | 1 | 1 | 4 | 2 | 0 |
| fluconazole | | conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug | environmental contaminant;
P450 inhibitor;
xenobiotic | 2017 | 2022 | 4.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| fluorouracil | | nucleobase analogue;
organofluorine compound | antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| flurbiprofen | | fluorobiphenyl;
monocarboxylic acid | antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fp 83 | | organic molecular entity | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| flutamide | | (trifluoromethyl)benzenes;
monocarboxylic acid amide | androgen antagonist;
antineoplastic agent | 2011 | 2011 | 13.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| fomepizole | | pyrazoles | antidote;
EC 1.1.1.1 (alcohol dehydrogenase) inhibitor;
protective agent | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| furosemide | | chlorobenzoic acid;
furans;
sulfonamide | environmental contaminant;
loop diuretic;
xenobiotic | 2008 | 2008 | 16.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| gabapentin | | gamma-amino acid | anticonvulsant;
calcium channel blocker;
environmental contaminant;
xenobiotic | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| gabexate | | benzoate ester | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| gemfibrozil | | aromatic ether | antilipemic drug | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| gentamicin | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glipizide | | aromatic amide;
monocarboxylic acid amide;
N-sulfonylurea;
pyrazines | EC 2.7.1.33 (pantothenate kinase) inhibitor;
hypoglycemic agent;
insulin secretagogue | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| glyburide | | monochlorobenzenes;
N-sulfonylurea | anti-arrhythmia drug;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor;
hypoglycemic agent | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| go 6976 | | indolocarbazole;
organic heterohexacyclic compound | EC 2.7.11.13 (protein kinase C) inhibitor | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| gossypol | | | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| guaifenesin | | methoxybenzenes | | 1999 | 2020 | 12.8 | low | 0 | 0 | 1 | 0 | 4 | 0 |
| 1-(5-isoquinolinesulfonyl)-2-methylpiperazine | | isoquinolines;
N-sulfonylpiperazine | EC 2.7.11.13 (protein kinase C) inhibitor | 1988 | 2003 | 32.4 | low | 0 | 3 | 1 | 1 | 0 | 0 |
| halothane | | haloalkane;
organobromine compound;
organochlorine compound;
organofluorine compound | inhalation anaesthetic | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| miltefosine | | phosphocholines;
phospholipid | anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| hexestrol | | stilbenoid | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| hexobarbital | | barbiturates | | 2010 | 2012 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| ethidium | | phenanthridines | fluorochrome;
intercalator | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| hydralazine | | azaarene;
hydrazines;
ortho-fused heteroarene;
phthalazines | antihypertensive agent;
vasodilator agent | 1982 | 1986 | 40.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| hydrochlorothiazide | | benzothiadiazine;
organochlorine compound;
sulfonamide | antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| hydroxyurea | | one-carbon compound;
ureas | antimetabolite;
antimitotic;
antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
genotoxin;
immunomodulator;
radical scavenger;
teratogenic agent | 1994 | 2018 | 16.3 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| hypericin | | | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ibuprofen | | monocarboxylic acid | antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic | 1985 | 1999 | 32.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| lidocaine | | benzenes;
monocarboxylic acid amide;
tertiary amino compound | anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic | 1987 | 2007 | 27.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| idebenone | | 1,4-benzoquinones;
primary alcohol | antioxidant;
ferroptosis inhibitor | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| imipramine | | dibenzoazepine | adrenergic uptake inhibitor;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| indole-3-carbinol | | indolyl alcohol | antineoplastic agent;
plant metabolite | 1997 | 1999 | 26.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| indomethacin | | aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole | analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic | 1981 | 2022 | 30.7 | low | 1 | 16 | 29 | 4 | 0 | 1 |
| iodoquinol | | monohydroxyquinoline;
organoiodine compound | antiamoebic agent;
antibacterial agent;
antiprotozoal drug;
antiseptic drug | 1981 | 1981 | 43.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 1-methyl-3-isobutylxanthine | | 3-isobutyl-1-methylxanthine | | 1994 | 2002 | 24.7 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| isoniazid | | carbohydrazide | antitubercular agent;
drug allergen | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2-propanol | | secondary alcohol;
secondary fatty alcohol | protic solvent | 1997 | 2020 | 16.0 | low | 0 | 0 | 1 | 1 | 2 | 0 |
| isoproterenol | | catechols;
secondary alcohol;
secondary amino compound | beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent | 1982 | 1998 | 34.3 | low | 0 | 7 | 6 | 0 | 0 | 0 |
| ketoconazole | | dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine | | 2012 | 2013 | 11.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| ketoprofen | | benzophenones;
oxo monocarboxylic acid | antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-steroidal anti-inflammatory drug;
xenobiotic | 1995 | 2006 | 23.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| khellin | | furanochromone;
organic heterotricyclic compound;
oxacycle | anti-asthmatic agent;
bronchodilator agent;
cardiovascular drug;
vasodilator agent | 1997 | 2000 | 25.5 | low | 0 | 0 | 4 | 0 | 0 | 0 |
| lauric acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
antibacterial agent;
plant metabolite | 1982 | 2019 | 18.6 | low | 2 | 1 | 7 | 11 | 10 | 0 |
| lomustine | | N-nitrosoureas;
organochlorine compound | alkylating agent;
antineoplastic agent | 1962 | 1962 | 62.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| loratadine | | benzocycloheptapyridine;
ethyl ester;
N-acylpiperidine;
organochlorine compound;
tertiary carboxamide | anti-allergic agent;
cholinergic antagonist;
geroprotector;
H1-receptor antagonist | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ly 171883 | | acetophenones;
aromatic ether;
phenols;
tetrazoles | anti-asthmatic drug;
leukotriene antagonist | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one | | chromones;
morpholines;
organochlorine compound | autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| mecamylamine | | primary aliphatic amine | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| mesalamine | | amino acid;
aromatic amine;
monocarboxylic acid;
monohydroxybenzoic acid;
phenols | non-steroidal anti-inflammatory drug | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| metformin | | guanidines | environmental contaminant;
geroprotector;
hypoglycemic agent;
xenobiotic | 2010 | 2011 | 13.5 | low | 1 | 0 | 0 | 1 | 1 | 0 |
| methyl methanesulfonate | | methanesulfonate ester | alkylating agent;
apoptosis inducer;
carcinogenic agent;
genotoxin;
mutagen | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| metronidazole | | C-nitro compound;
imidazoles;
primary alcohol | antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| midodrine | | amino acid amide;
aromatic ether;
secondary alcohol | alpha-adrenergic agonist;
prodrug;
sympathomimetic agent;
vasoconstrictor agent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| mitotane | | diarylmethane | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| mitoxantrone | | dihydroxyanthraquinone | analgesic;
antineoplastic agent | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| molsidomine | | ethyl ester;
morpholines;
oxadiazole;
zwitterion | antioxidant;
apoptosis inhibitor;
cardioprotective agent;
nitric oxide donor;
vasodilator agent | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| n-(6-aminohexyl)-1-naphthalenesulfonamide | | naphthalenes;
sulfonic acid derivative | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| nabumetone | | methoxynaphthalene;
methyl ketone | cyclooxygenase 2 inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug | 2000 | 2005 | 21.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| neostigmine | | quaternary ammonium ion | antidote to curare poisoning;
EC 3.1.1.7 (acetylcholinesterase) inhibitor | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| nifedipine | | C-nitro compound;
dihydropyridine;
methyl ester | calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent | 1991 | 2011 | 24.2 | low | 0 | 0 | 2 | 1 | 1 | 0 |
| nisoldipine | | C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
methyl ester | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide | | aromatic ether;
C-nitro compound;
sulfonamide | antineoplastic agent;
cyclooxygenase 2 inhibitor | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| oxidopamine | | benzenetriol;
catecholamine;
primary amino compound | drug metabolite;
human metabolite;
neurotoxin | 2010 | 2022 | 8.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| aminosalicylic acid | | aminobenzoic acid;
phenols | antitubercular agent | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| quinone | | 1,4-benzoquinones | cofactor;
human xenobiotic metabolite;
mouse metabolite | 2005 | 2008 | 17.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| pd 98059 | | aromatic amine;
monomethoxyflavone | EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pentobarbital | | barbiturates | GABAA receptor agonist | 1993 | 2000 | 27.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| pentoxifylline | | oxopurine | | 1997 | 2021 | 12.2 | low | 1 | 0 | 1 | 1 | 2 | 1 |
| perhexiline | | piperidines | cardiovascular drug | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phenobarbital | | barbiturates | anticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative | 1986 | 1996 | 32.1 | low | 0 | 1 | 6 | 0 | 0 | 0 |
| pindolol | | indoles;
secondary amine | antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist;
serotonergic antagonist;
vasodilator agent | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| pioglitazone | | aromatic ether;
pyridines;
thiazolidinediones | antidepressant;
cardioprotective agent;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hypoglycemic agent;
insulin-sensitizing drug;
PPARgamma agonist;
xenobiotic | 1995 | 2023 | 14.3 | low | 1 | 0 | 1 | 0 | 1 | 1 |
| pomiferin | | isoflavanones | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| potassium chloride | | inorganic chloride;
inorganic potassium salt;
potassium salt | fertilizer | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| potassium iodide | | potassium salt | expectorant;
radical scavenger | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| proadifen | | diarylmethane | | 1991 | 2001 | 28.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| probenecid | | benzoic acids;
sulfonamide | uricosuric drug | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| probucol | | dithioketal;
polyphenol | anti-inflammatory drug;
anticholesteremic drug;
antilipemic drug;
antioxidant;
cardiovascular drug | 1989 | 2011 | 27.7 | low | 0 | 1 | 4 | 0 | 1 | 0 |
| procainamide | | benzamides | anti-arrhythmia drug;
platelet aggregation inhibitor;
sodium channel blocker | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| proglumide | | benzamides;
dicarboxylic acid monoamide;
glutamine derivative;
racemate | anti-ulcer drug;
cholecystokinin antagonist;
cholinergic antagonist;
delta-opioid receptor agonist;
drug metabolite;
gastrointestinal drug;
opioid analgesic;
xenobiotic metabolite | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| propidium | | phenanthridines;
quaternary ammonium ion | fluorochrome;
intercalator | 2000 | 2001 | 23.7 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| propofol | | phenols | anticonvulsant;
antiemetic;
intravenous anaesthetic;
radical scavenger;
sedative | 2005 | 2013 | 14.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| propranolol | | naphthalenes;
propanolamine;
secondary amine | anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic | 1987 | 2008 | 27.7 | low | 0 | 1 | 1 | 1 | 0 | 0 |
| propyl gallate | | trihydroxybenzoic acid | | 1997 | 2013 | 19.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| pf 5901 | | quinolines | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1,6-bis(cyclohexyloximinocarbonyl)hexane | | carbamate ester;
organonitrogen compound | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ro 31-8220 | | imidothiocarbamic ester;
indoles;
maleimides | EC 2.7.11.13 (protein kinase C) inhibitor | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone | | methoxybenzenes | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| saccharin | | 1,2-benzisothiazole;
N-sulfonylcarboxamide | environmental contaminant;
sweetening agent;
xenobiotic | 1996 | 2007 | 21.3 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| safrole | | benzodioxoles | flavouring agent;
insecticide;
metabolite;
plant metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sebacic acid | | alpha,omega-dicarboxylic acid;
dicarboxylic fatty acid | human metabolite;
plant metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| linsidomine | | morpholines | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sodium fluoride | | fluoride salt | mutagen | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| stearic acid | | long-chain fatty acid;
saturated fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
human metabolite;
plant metabolite | 1956 | 2021 | 31.1 | medium | 12 | 95 | 74 | 69 | 52 | 3 |
| sulfacetamide | | N-sulfonylcarboxamide;
substituted aniline | antibacterial drug;
antiinfective agent;
antimicrobial agent;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| sulfamethazine | | pyrimidines;
sulfonamide antibiotic;
sulfonamide | antibacterial drug;
antiinfective agent;
antimicrobial agent;
carcinogenic agent;
drug allergen;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
ligand;
xenobiotic | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| sulpiride | | benzamides;
N-alkylpyrrolidine;
sulfonamide | antidepressant;
antiemetic;
antipsychotic agent;
dopaminergic antagonist | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| suprofen | | aromatic ketone;
monocarboxylic acid;
thiophenes | antirheumatic drug;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| tetracaine | | benzoate ester;
tertiary amino compound | local anaesthetic | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| tetraethylammonium | | quaternary ammonium ion | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 2,4-thiazolidinedione | | thiazolidenedione | | 2001 | 2003 | 22.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| tiaprofenic acid | | aromatic ketone;
monocarboxylic acid;
thiophenes | drug allergen;
non-steroidal anti-inflammatory drug | 1994 | 2001 | 25.7 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| ticlopidine | | monochlorobenzenes;
thienopyridine | anticoagulant;
fibrin modulating drug;
hematologic agent;
P2Y12 receptor antagonist;
platelet aggregation inhibitor | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tolbutamide | | N-sulfonylurea | human metabolite;
hypoglycemic agent;
insulin secretagogue;
potassium channel blocker | 1963 | 2008 | 38.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine | | N-substituted diamine;
pyridines;
tertiary amino compound | apoptosis inducer;
chelator;
copper chelator | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| triamterene | | pteridines | diuretic;
sodium channel blocker | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| trifluoperazine | | N-alkylpiperazine;
N-methylpiperazine;
organofluorine compound;
phenothiazines | antiemetic;
calmodulin antagonist;
dopaminergic antagonist;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor;
phenothiazine antipsychotic drug | 1984 | 2002 | 30.8 | low | 0 | 2 | 1 | 1 | 0 | 0 |
| troglitazone | | chromanes;
thiazolidinone | anticoagulant;
anticonvulsant;
antineoplastic agent;
antioxidant;
EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
hypoglycemic agent;
platelet aggregation inhibitor;
vasodilator agent | 1995 | 2007 | 23.0 | low | 1 | 0 | 2 | 3 | 0 | 0 |
| tyramine | | monoamine molecular messenger;
primary amino compound;
tyramines | EC 3.1.1.8 (cholinesterase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| w 7 | | | | 1984 | 1988 | 38.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| pirinixic acid | | aryl sulfide;
organochlorine compound;
pyrimidines | | 1984 | 2012 | 19.7 | low | 0 | 1 | 2 | 7 | 2 | 0 |
| hydrocortisone acetate | | cortisol ester;
tertiary alpha-hydroxy ketone | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| mitomycin | | mitomycin | alkylating agent;
antineoplastic agent | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| corticosterone | | 11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone | human metabolite;
mouse metabolite | 1982 | 2014 | 25.1 | low | 0 | 1 | 2 | 3 | 1 | 0 |
| prednisolone | | 11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
drug metabolite;
environmental contaminant;
immunosuppressive agent;
xenobiotic | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| estriol | | 16alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid | estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite | 1964 | 2006 | 39.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| sorbitol | | glucitol | cathartic;
Escherichia coli metabolite;
food humectant;
human metabolite;
laxative;
metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite;
sweetening agent | 1991 | 2016 | 20.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| alloxan | | pyrimidone | hyperglycemic agent;
metabolite | 1986 | 2006 | 29.3 | low | 0 | 1 | 1 | 1 | 0 | 0 |
| thymidine | | pyrimidine 2'-deoxyribonucleoside | Escherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite | 1988 | 2005 | 28.3 | low | 0 | 2 | 6 | 3 | 0 | 0 |
| hydroxyproline | | 4-hydroxyproline;
L-alpha-amino acid zwitterion | human metabolite;
mouse metabolite;
plant metabolite | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| thyroxine | | 2-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine | antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone | 1964 | 2022 | 32.2 | low | 0 | 2 | 1 | 0 | 0 | 1 |
| carbachol | | ammonium salt;
carbamate ester | cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic | 1987 | 2005 | 29.4 | low | 0 | 2 | 1 | 2 | 0 | 0 |
| aldosterone | | 11beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde | human metabolite;
mouse metabolite | 1990 | 2020 | 19.6 | low | 0 | 0 | 1 | 3 | 1 | 0 |
| prednisone | | 11-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
immunosuppressive agent;
prodrug | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| estrone | | 17-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols | antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite | 1964 | 2009 | 28.5 | low | 0 | 1 | 0 | 3 | 0 | 0 |
| androsterone | | 17-oxo steroid;
3alpha-hydroxy steroid;
androstanoid;
C19-steroid | androgen;
anticonvulsant;
human blood serum metabolite;
human metabolite;
human urinary metabolite;
mouse metabolite;
pheromone | 1964 | 2003 | 40.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| dehydroepiandrosterone | | 17-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
androstanoid | androgen;
human metabolite;
mouse metabolite | 1993 | 2015 | 20.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| 2-acetylaminofluorene | | 2-acetamidofluorenes | antimitotic;
carcinogenic agent;
epitope;
mutagen | 1987 | 1988 | 36.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| pentylenetetrazole | | organic heterobicyclic compound;
organonitrogen heterocyclic compound | | 2009 | 2014 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| triiodothyronine | | 2-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine | human metabolite;
mouse metabolite;
thyroid hormone | 1982 | 2022 | 28.1 | low | 0 | 3 | 3 | 0 | 1 | 1 |
| diethylnitrosamine | | nitrosamine | carcinogenic agent;
hepatotoxic agent;
mutagen | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| isoflurophate | | dialkyl phosphate | | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| carbon tetrachloride | | chlorocarbon;
chloromethanes | hepatotoxic agent;
refrigerant | 1982 | 2023 | 25.4 | low | 0 | 5 | 1 | 3 | 1 | 1 |
| alanine | | alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid | EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite | 1985 | 2023 | 15.9 | low | 0 | 1 | 1 | 2 | 2 | 2 |
| serine | | L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1964 | 2023 | 22.0 | low | 0 | 3 | 1 | 4 | 2 | 3 |
| benz(a)anthracene | | ortho-fused polycyclic arene;
tetraphenes | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| aspartic acid | | aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
mouse metabolite;
neurotransmitter | 1985 | 2022 | 15.6 | low | 0 | 1 | 1 | 0 | 1 | 2 |
| glutamine | | amino acid zwitterion;
glutamine family amino acid;
glutamine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid | EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 1997 | 2020 | 14.7 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| lysine | | aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid | algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1964 | 2023 | 23.6 | low | 0 | 3 | 3 | 5 | 1 | 2 |
| cyanides | | pseudohalide anion | EC 1.9.3.1 (cytochrome c oxidase) inhibitor | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| sucrose | | glycosyl glycoside | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent | 1964 | 2022 | 21.7 | low | 2 | 5 | 6 | 11 | 3 | 4 |
| 9,10-dimethyl-1,2-benzanthracene | | ortho-fused polycyclic arene;
tetraphenes | carcinogenic agent | 1984 | 2017 | 28.5 | low | 0 | 3 | 13 | 2 | 1 | 0 |
| adenosine diphosphate | | adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate | fundamental metabolite;
human metabolite | 1984 | 2008 | 29.1 | low | 2 | 5 | 4 | 6 | 0 | 0 |
| uridine | | uridines | drug metabolite;
fundamental metabolite;
human metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bromodeoxyuridine | | pyrimidine 2'-deoxyribonucleoside | antimetabolite;
antineoplastic agent | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| galactose | | D-galactose;
galactopyranose | Escherichia coli metabolite;
mouse metabolite | 1964 | 2022 | 32.0 | low | 0 | 3 | 2 | 0 | 1 | 1 |
| carbostyril | | monohydroxyquinoline;
quinolone | bacterial xenobiotic metabolite | 1995 | 2021 | 14.0 | low | 0 | 0 | 1 | 2 | 1 | 1 |
| phenylephrine | | phenols;
phenylethanolamines;
secondary amino compound | alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| levodopa | | amino acid zwitterion;
dopa;
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid | allelochemical;
antidyskinesia agent;
antiparkinson drug;
dopaminergic agent;
hapten;
human metabolite;
mouse metabolite;
neurotoxin;
plant growth retardant;
plant metabolite;
prodrug | 1994 | 2018 | 18.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| edetic acid | | ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid | anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector | 1984 | 2008 | 26.2 | low | 0 | 2 | 6 | 6 | 0 | 0 |
| tributyrin | | butyrate ester;
triglyceride | antineoplastic agent;
apoptosis inducer;
EC 3.5.1.98 (histone deacetylase) inhibitor;
prodrug;
protective agent | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| p-dimethylaminoazobenzene | | azobenzenes | | 1965 | 1965 | 59.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| phenylethyl alcohol | | benzenes;
primary alcohol | Aspergillus metabolite;
fragrance;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1993 | 2016 | 14.9 | low | 0 | 0 | 1 | 2 | 4 | 0 |
| tyrosine | | amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine | EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical | 1984 | 2022 | 20.2 | low | 2 | 1 | 6 | 11 | 3 | 1 |
| monomethylhydrazine | | | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| adenosine monophosphate | | adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate | adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methylene blue | | organic chloride salt | acid-base indicator;
antidepressant;
antimalarial;
antimicrobial agent;
antioxidant;
cardioprotective agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 4.6.1.2 (guanylate cyclase) inhibitor;
fluorochrome;
histological dye;
neuroprotective agent;
physical tracer | 1992 | 2009 | 23.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| 4-toluenesulfonic acid | | arenesulfonic acid;
toluenes | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| leucine | | amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1987 | 2012 | 22.5 | low | 0 | 2 | 2 | 5 | 2 | 0 |
| aniline | | anilines;
primary arylamine | | 1995 | 1995 | 29.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| 2-aminoisobutyric acid | | 2,2-dialkylglycine zwitterion;
2,2-dialkylglycine | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| androstenedione | | 17-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid | androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| lactose | | lactose | | 1986 | 2012 | 20.2 | low | 1 | 1 | 1 | 2 | 2 | 0 |
| methionine | | aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid | antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical | 1964 | 2022 | 21.3 | low | 1 | 1 | 4 | 5 | 2 | 1 |
| 1,2-dipalmitoylphosphatidylcholine | | | | 1987 | 2016 | 21.1 | low | 0 | 1 | 2 | 3 | 2 | 0 |
| phenylalanine | | amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid | algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1992 | 2023 | 14.4 | low | 3 | 0 | 3 | 4 | 4 | 3 |
| desoxycorticosterone | | 20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
mineralocorticoid;
primary alpha-hydroxy ketone | human metabolite;
mouse metabolite | 1990 | 1990 | 34.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| colchicine | | alkaloid;
colchicine | anti-inflammatory agent;
gout suppressant;
mutagen | 1983 | 1993 | 34.7 | low | 0 | 1 | 2 | 0 | 0 | 0 |
| cytidine | | cytidines | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| cytidine triphosphate | | cytidine 5'-phosphate;
pyrimidine ribonucleoside 5'-triphosphate | Escherichia coli metabolite;
mouse metabolite | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| n-hexanal | | medium-chain fatty aldehyde;
n-alkanal;
saturated fatty aldehyde | human urinary metabolite | 1990 | 2023 | 14.2 | low | 0 | 0 | 2 | 3 | 6 | 1 |
| strophanthidin | | 14beta-hydroxy steroid;
19-oxo steroid;
3beta-hydroxy steroid;
5beta-hydroxy steroid;
cardenolides;
steroid aldehyde | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cycloheximide | | antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol | anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor | 1988 | 2006 | 28.6 | low | 0 | 1 | 4 | 2 | 0 | 0 |
| egtazic acid | | diether;
tertiary amino compound;
tetracarboxylic acid | chelator | 1993 | 1995 | 30.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| barbituric acid | | barbiturates | allergen;
xenobiotic | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| chloroform | | chloromethanes;
one-carbon compound | carcinogenic agent;
central nervous system drug;
inhalation anaesthetic;
non-polar solvent;
refrigerant | 1965 | 2022 | 33.8 | low | 0 | 2 | 0 | 1 | 0 | 1 |
| fluocinolone acetonide | | 11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
cyclic ketal;
fluorinated steroid;
glucocorticoid;
organic heteropentacyclic compound;
primary alpha-hydroxy ketone | anti-inflammatory drug;
antipruritic drug | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sodium citrate, anhydrous | | organic sodium salt | anticoagulant;
flavouring agent | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| mannitol | | mannitol | allergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent | 1989 | 2018 | 21.0 | low | 0 | 1 | 3 | 0 | 3 | 0 |
| cytarabine | | beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside | antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| trifluridine | | nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside | antimetabolite;
antineoplastic agent;
antiviral drug;
EC 2.1.1.45 (thymidylate synthase) inhibitor | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ornithine | | non-proteinogenic L-alpha-amino acid;
ornithine | algal metabolite;
hepatoprotective agent;
mouse metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| histidine | | amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 1994 | 2011 | 21.2 | low | 0 | 0 | 2 | 7 | 1 | 0 |
| n-pentanol | | pentanol;
short-chain primary fatty alcohol | human metabolite;
plant metabolite | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| medroxyprogesterone acetate | | 20-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
corticosteroid;
steroid ester | adjuvant;
androgen;
antineoplastic agent;
antioxidant;
female contraceptive drug;
inhibitor;
progestin;
synthetic oral contraceptive | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| valine | | L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 2001 | 2022 | 13.5 | low | 0 | 0 | 0 | 4 | 1 | 1 |
| threonine | | amino acid zwitterion;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
threonine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1964 | 2022 | 17.5 | low | 0 | 1 | 0 | 0 | 1 | 2 |
| cordycepin | | 3'-deoxyribonucleoside;
adenosines | antimetabolite;
nucleoside antibiotic | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| tryptophan | | erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan | antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1990 | 2023 | 16.9 | low | 0 | 0 | 7 | 3 | 4 | 3 |
| isoleucine | | aspartate family amino acid;
isoleucine;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1964 | 2022 | 17.0 | low | 0 | 1 | 0 | 1 | 3 | 1 |
| arginine | | arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical | 1984 | 2023 | 21.8 | low | 1 | 1 | 4 | 0 | 1 | 2 |
| ethane | | alkane;
gas molecular entity | plant metabolite;
refrigerant | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ethylene | | alkene;
gas molecular entity | plant hormone;
refrigerant | 1995 | 2018 | 17.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| acetylene | | alkyne;
gas molecular entity;
terminal acetylenic compound | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| boranes | | boranes;
mononuclear parent hydride | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| propane | | alkane;
gas molecular entity | food propellant | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| acetonitrile | | aliphatic nitrile;
volatile organic compound | EC 3.5.1.4 (amidase) inhibitor;
NMR chemical shift reference compound;
polar aprotic solvent | 1997 | 2018 | 17.8 | low | 0 | 0 | 1 | 3 | 1 | 0 |
| methylene chloride | | chloromethanes;
volatile organic compound | carcinogenic agent;
polar aprotic solvent;
refrigerant | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cyclopropane | | cycloalkane;
cyclopropanes | inhalation anaesthetic | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| boron trifluoride | | boron fluoride | NMR chemical shift reference compound | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| tert-butyl alcohol | | tertiary alcohol | human xenobiotic metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| tert-amyl alcohol | | aliphatic alcohol;
tertiary alcohol | protic solvent | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| tert-butylhydroperoxide | | alkyl hydroperoxide | antibacterial agent;
oxidising agent | 1993 | 2017 | 20.6 | low | 0 | 0 | 3 | 3 | 2 | 0 |
| trifluoroacetic acid | | fluoroalkanoic acid | human xenobiotic metabolite;
NMR chemical shift reference compound;
reagent | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| triamcinolone acetonide | | 11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
cyclic ketal;
fluorinated steroid;
glucocorticoid;
primary alpha-hydroxy ketone | anti-allergic agent;
anti-inflammatory drug | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| phencyclidine | | benzenes;
piperidines | anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| quinic acid | | | | 2005 | 2022 | 10.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| trimethylolpropane | | primary alcohol | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| triparanol | | stilbenoid | anticoronaviral agent | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| azobis(isobutyronitrile) | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| linalool | | monoterpenoid;
tertiary alcohol | antimicrobial agent;
fragrance;
plant metabolite;
volatile oil component | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| chloroacetyl chloride | | acyl halide | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| acrylamide | | acrylamides;
N-acylammonia;
primary carboxamide | alkylating agent;
carcinogenic agent;
Maillard reaction product;
mutagen;
neurotoxin | 2008 | 2019 | 10.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| acrylic acid | | alpha,beta-unsaturated monocarboxylic acid | metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methyl chloroformate | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| isobutyric acid | | branched-chain saturated fatty acid;
fatty acid 4:0;
methyl-branched fatty acid | Daphnia magna metabolite;
plant metabolite;
volatile oil component | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bisphenol a | | bisphenol | endocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| alpha-pinene | | pinene | plant metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| methylmethacrylate | | enoate ester;
methyl ester | allergen;
polymerisation monomer | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| taurocholic acid | | amino sulfonic acid;
bile acid taurine conjugate | human metabolite | 1992 | 2022 | 16.0 | low | 0 | 0 | 1 | 1 | 1 | 1 |
| skatole | | methylindole | human metabolite;
mammalian metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methylprednisolone | | 6-methylprednisolone;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | adrenergic agent;
anti-inflammatory drug;
antiemetic;
environmental contaminant;
neuroprotective agent;
xenobiotic | 1995 | 1995 | 29.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| rotenone | | organic heteropentacyclic compound;
rotenones | antineoplastic agent;
metabolite;
mitochondrial NADH:ubiquinone reductase inhibitor;
phytogenic insecticide;
piscicide;
toxin | 2015 | 2018 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| pyocyanine | | iminium betaine;
phenazines | antibacterial agent;
bacterial metabolite;
biological pigment;
virulence factor | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| xylitol | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| n-vinyl-2-pyrrolidinone | | pyrrolidin-2-ones | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| thymol | | monoterpenoid;
phenols | volatile oil component | 2004 | 2012 | 16.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| anthrone | | anthracenone | radical scavenger | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| quinoxalines | | mancude organic heterobicyclic parent;
naphthyridine;
ortho-fused heteroarene | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| quinoline | | azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinolines | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 2-naphthylamine | | naphthylamine | carcinogenic agent | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3,3'-dichlorobenzidine | | biphenyls;
monochlorobenzenes;
organochlorine compound | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| diphenyl | | aromatic fungicide;
benzenes;
biphenyls | antifungal agrochemical;
antimicrobial food preservative | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzidine | | biphenyls;
substituted aniline | carcinogenic agent | 1996 | 2007 | 22.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| methyleugenol | | phenylpropanoid | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| propylparaben | | benzoate ester;
paraben;
phenols | antifungal agent;
antimicrobial agent | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzoyl peroxide | | carbonyl compound | | 2003 | 2022 | 11.5 | low | 1 | 0 | 0 | 1 | 0 | 1 |
| alpha-chlorohydrin | | chloropropane-1,2-diol | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| thioglycerol | | propane-1,2-diols;
thiol | reducing agent;
vulnerary | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 4-butyrolactone | | butan-4-olide | metabolite;
neurotoxin | 1986 | 2020 | 16.2 | low | 0 | 1 | 1 | 1 | 3 | 0 |
| lactobionic acid | | disaccharide | antioxidant | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| furfuryl alcohol | | furans;
primary alcohol | Maillard reaction product | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cumene | | alkylbenzene | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trehalose | | trehalose | Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1997 | 2012 | 21.8 | low | 0 | 0 | 2 | 1 | 1 | 0 |
| 4-bromophenacyl bromide | | | | 1988 | 1999 | 29.3 | low | 0 | 1 | 2 | 0 | 0 | 0 |
| gamma-terpinene | | cyclohexadiene;
monoterpene | antioxidant;
human xenobiotic metabolite;
plant metabolite;
volatile oil component | 2003 | 2011 | 16.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| 4-cymene | | monoterpene;
toluenes | human urinary metabolite;
plant metabolite;
volatile oil component | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| terephthalic acid | | benzenedicarboxylic acid | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phenylhydrazine | | phenylhydrazines | xenobiotic | 1955 | 1986 | 55.7 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| anisole | | monomethoxybenzene | plant metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| quinuclidines | | quinuclidines;
saturated organic heterobicyclic parent | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| triethanolamine | | amino alcohol;
tertiary amino compound;
triol | buffer;
surfactant | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-anisidine | | methoxybenzenes;
primary amino compound;
substituted aniline | genotoxin;
reagent | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| citronellal | | aldehyde;
monoterpenoid | antifungal agent;
metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-vinyl-1-cyclohexene dioxide | | epoxide | carcinogenic agent | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ethylene dibromide | | bromoalkane;
bromohydrocarbon | algal metabolite;
carcinogenic agent;
fumigant;
marine metabolite;
mouse metabolite;
mutagen | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| acrolein | | enal | herbicide;
human xenobiotic metabolite;
toxin | 1990 | 2016 | 20.1 | low | 0 | 0 | 2 | 3 | 2 | 0 |
| allylamine | | alkylamine | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| allyl alcohol | | primary allylic alcohol;
propenol | antibacterial agent;
fungicide;
herbicide;
insecticide;
plant metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glyoxal | | dialdehyde | agrochemical;
allergen;
pesticide;
plant growth regulator | 2001 | 2023 | 11.7 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| 2-methylpentane | | alkane | | 2003 | 2022 | 8.9 | low | 0 | 0 | 0 | 3 | 11 | 2 |
| chlorobenzene | | monochlorobenzenes | solvent | 1996 | 2018 | 17.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| cyclohexanol | | cyclohexanols;
secondary alcohol | solvent | 2009 | 2012 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| thiophenol | | aryl thiol | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n-pentanoic acid | | short-chain fatty acid;
straight-chain saturated fatty acid | plant metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pentane | | alkane;
volatile organic compound | non-polar solvent;
refrigerant | 1989 | 1995 | 32.0 | low | 0 | 1 | 2 | 0 | 0 | 0 |
| vinyl ether | | ether | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pyrroles | | pyrrole;
secondary amine | | 1986 | 2020 | 22.2 | low | 0 | 1 | 1 | 2 | 1 | 0 |
| furan | | furans;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | carcinogenic agent;
hepatotoxic agent;
Maillard reaction product | 2006 | 2015 | 14.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| thiophenes | | mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound | non-polar solvent | 2001 | 2013 | 17.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| di-tert-butyl peroxide | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| n-hexane | | alkane;
volatile organic compound | neurotoxin;
non-polar solvent | 2016 | 2022 | 5.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| pentanal | | saturated fatty aldehyde | plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| piperidine | | azacycloalkane;
piperidines;
saturated organic heteromonocyclic parent;
secondary amine | base;
catalyst;
human metabolite;
non-polar solvent;
plant metabolite;
protic solvent;
reagent | 1984 | 2010 | 27.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| morpholine | | morpholines;
saturated organic heteromonocyclic parent | NMR chemical shift reference compound | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-hexanol | | hexanol;
primary alcohol | alarm pheromone;
antibacterial agent;
fragrance;
plant metabolite | 2012 | 2020 | 8.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| ethyl stearate | | long-chain fatty acid ethyl ester;
octadecanoate ester | plant metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| heptanal | | medium-chain fatty aldehyde;
n-alkanal;
saturated fatty aldehyde | biomarker | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| carbitol | | diether;
glycol ether;
hydroxypolyether;
primary alcohol | protic solvent | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pelargonic acid | | medium-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
antifeedant;
Daphnia magna metabolite;
plant metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| methyl palmitate | | fatty acid methyl ester | metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| n-dodecane | | alkane | plant metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dodecanol | | dodecanol;
primary alcohol | bacterial metabolite;
cosmetic;
insect attractant;
insecticide;
pheromone;
plant metabolite | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| palmitoyl chloride | | | | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| myristyl alcohol | | long-chain primary fatty alcohol;
tetradecanol | pheromone;
plant metabolite;
volatile oil component | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| behenic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | plant metabolite | 1998 | 2018 | 17.7 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| stearyl alcohol | | long-chain primary fatty alcohol;
octadecanol | algal metabolite;
human metabolite;
plant metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dicofol | | monochlorobenzenes;
organochlorine acaricide;
tertiary alcohol | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| diethylhexyl phthalate | | diester;
phthalate ester | androstane receptor agonist;
apoptosis inhibitor;
plasticiser | 1984 | 2004 | 30.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| framycetin | | aminoglycoside | allergen;
antibacterial drug;
Escherichia coli metabolite | 1962 | 1962 | 62.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| dianisidine | | biphenyls | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-tolidine | | biphenyls | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| vanillic acid | | methoxybenzoic acid;
monohydroxybenzoic acid | plant metabolite | 2002 | 2022 | 13.0 | low | 0 | 0 | 0 | 2 | 1 | 1 |
| pyrazolanthrone | | anthrapyrazole;
aromatic ketone;
cyclic ketone | antineoplastic agent;
c-Jun N-terminal kinase inhibitor;
geroprotector | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| shikimic acid | | alpha,beta-unsaturated monocarboxylic acid;
cyclohexenecarboxylic acid;
hydroxy monocarboxylic acid | Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| nitrilotriacetic acid | | NTA;
tricarboxylic acid | carcinogenic agent;
nephrotoxic agent | 1989 | 2005 | 27.8 | low | 0 | 1 | 2 | 2 | 0 | 0 |
| estragole | | alkenylbenzene;
monomethoxybenzene;
phenylpropanoid | carcinogenic agent;
flavouring agent;
genotoxin;
insect attractant;
plant metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ethyl acetate | | acetate ester;
ethyl ester;
volatile organic compound | EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor;
metabolite;
polar aprotic solvent;
Saccharomyces cerevisiae metabolite | 2000 | 2023 | 14.9 | low | 0 | 0 | 1 | 4 | 1 | 2 |
| cupric acetate | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sodium cyanide | | cyanide salt;
one-carbon compound;
sodium salt | EC 1.15.1.1 (superoxide dismutase) inhibitor | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| diphenhydramine hydrochloride | | hydrochloride;
organoammonium salt | anti-allergic agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
sedative | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| potassium cyanide | | cyanide salt;
one-carbon compound;
potassium salt | EC 1.15.1.1 (superoxide dismutase) inhibitor;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
neurotoxin | 1983 | 1998 | 33.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| catechin | | catechin | antioxidant;
plant metabolite | 1997 | 2021 | 16.6 | low | 0 | 0 | 4 | 11 | 4 | 2 |
| perylene | | ortho- and peri-fused polycyclic arene;
perylenes | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| quinazolines | | azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| acridines | | acridines;
mancude organic heterotricyclic parent;
polycyclic heteroarene | genotoxin | 1984 | 1993 | 35.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| adamantane | | adamantanes;
polycyclic alkane | | 2019 | 2021 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| cyclopentane | | cycloalkane;
cyclopentanes;
volatile organic compound | non-polar solvent | 2000 | 2022 | 13.3 | low | 0 | 0 | 1 | 10 | 9 | 1 |
| oxazoles | | 1,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | | 1993 | 2017 | 19.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| thiazoles | | 1,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | | 1995 | 2016 | 21.6 | low | 1 | 0 | 7 | 9 | 2 | 0 |
| pyrimidine | | diazine;
pyrimidines | Daphnia magna metabolite | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pyrazines | | diazine;
pyrazines | Daphnia magna metabolite | 2003 | 2023 | 13.2 | low | 0 | 0 | 0 | 2 | 2 | 1 |
| nitroblue tetrazolium | | organic cation | | 1987 | 2005 | 27.8 | low | 0 | 1 | 1 | 2 | 0 | 0 |
| ephedrine | | phenethylamine alkaloid;
phenylethanolamines | bacterial metabolite;
environmental contaminant;
nasal decongestant;
plant metabolite;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| hydrazine | | azane;
hydrazines | EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor | 1964 | 2008 | 20.5 | low | 0 | 1 | 1 | 17 | 0 | 0 |
| thiocyanate | | pseudohalide anion;
sulfur molecular entity | human metabolite | 1995 | 2003 | 25.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| paraoxon | | aryl dialkyl phosphate;
organophosphate insecticide | EC 3.1.1.7 (acetylcholinesterase) inhibitor;
mouse metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| azacitidine | | N-glycosyl-1,3,5-triazine;
nucleoside analogue | antineoplastic agent | 2013 | 2014 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| diazomethane | | diazo compound | alkylating agent;
antineoplastic agent;
carcinogenic agent;
poison | 1994 | 2001 | 26.5 | low | 0 | 0 | 3 | 1 | 0 | 0 |
| perfluorooctanoic acid | | fluoroalkanoic acid | carcinogenic agent;
endocrine disruptor;
environmental contaminant;
surfactant;
xenobiotic | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| citrulline | | amino acid zwitterion;
citrulline | Daphnia magna metabolite;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
protective agent;
Saccharomyces cerevisiae metabolite | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| perflubron | | haloalkane;
organobromine compound;
perfluorinated compound | blood substitute;
radioopaque medium | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| lithocholic acid | | bile acid;
C24-steroid;
monohydroxy-5beta-cholanic acid | geroprotector;
human metabolite;
mouse metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| limestone | | calcium salt;
carbonate salt;
inorganic calcium salt;
one-carbon compound | antacid;
fertilizer;
food colouring;
food firming agent | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| chenodeoxycholic acid | | bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid | human metabolite;
mouse metabolite | 2020 | 2020 | 4.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| glycocholic acid | | bile acid glycine conjugate | human metabolite | 1990 | 2022 | 23.0 | low | 0 | 0 | 4 | 2 | 0 | 1 |
| fusarium | | | | 2010 | 2019 | 8.7 | low | 0 | 0 | 0 | 1 | 10 | 0 |
| rhein | | dihydroxyanthraquinone | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aloe emodin | | aromatic primary alcohol;
dihydroxyanthraquinone | antineoplastic agent;
plant metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| diphenic acid | | dicarboxylic acid | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| dihydralazine | | phthalazines | | 1982 | 1986 | 40.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| reticulin | | benzylisoquinoline alkaloid;
benzyltetrahydroisoquinoline;
isoquinolinol | plant metabolite | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| bicuculline | | benzylisoquinoline alkaloid;
isoquinoline alkaloid;
isoquinolines | agrochemical;
central nervous system stimulant;
GABA-gated chloride channel antagonist;
GABAA receptor antagonist;
neurotoxin | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| kainic acid | | dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid | antinematodal drug;
excitatory amino acid agonist | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| bufotenin | | tertiary amine;
tryptamine alkaloid | coral metabolite;
hallucinogen | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| thymoquinone | | 1,4-benzoquinones | adjuvant;
anti-inflammatory agent;
antidepressant;
antineoplastic agent;
antioxidant;
cardioprotective agent;
plant metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzohydroxamic acid | | | | 1998 | 2001 | 24.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| carvacrol | | botanical anti-fungal agent;
p-menthane monoterpenoid;
phenols | agrochemical;
antimicrobial agent;
flavouring agent;
TRPA1 channel agonist;
volatile oil component | 2004 | 2012 | 16.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| indophenol | | quinone imine | dye | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 4-hydroxyphenylethanol | | phenols | anti-arrhythmia drug;
antioxidant;
cardiovascular drug;
fungal metabolite;
geroprotector;
plant metabolite;
protective agent | 2010 | 2015 | 11.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| margaric acid | | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
mammalian metabolite | 1990 | 2014 | 25.0 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| 16-hydroxypalmitic acid | | hydroxypalmitic acid;
omega-hydroxy-long-chain fatty acid | plant metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| arachidic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | plant metabolite | 1996 | 2020 | 13.0 | low | 0 | 0 | 1 | 1 | 4 | 0 |
| hexacosanoic acid | | fatty acid 26:0;
straight-chain saturated fatty acid;
very long-chain fatty acid | | 1996 | 2015 | 18.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| oleanolic acid | | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | plant metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tetranitromethane | | organonitrogen compound | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| abietic acid | | abietane diterpenoid;
monocarboxylic acid | plant metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| periplogenin | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| kryptopyrrole | | | | 1986 | 1986 | 38.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| medroxyprogesterone | | 17alpha-hydroxy steroid;
20-oxo steroid;
3-oxo-Delta(4) steroid;
tertiary alpha-hydroxy ketone | contraceptive drug;
progestin;
synthetic oral contraceptive | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| dihydrotestosterone | | 17beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid | androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite | 1988 | 1998 | 31.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| luminol | | | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| angelicin | | furanocoumarin | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| gluconic acid | | gluconic acid | chelator;
Penicillium metabolite | 2007 | 2012 | 14.5 | low | 1 | 0 | 0 | 1 | 1 | 0 |
| copper gluconate | | organic molecular entity | | 2007 | 2012 | 14.5 | low | 1 | 0 | 0 | 1 | 1 | 0 |
| cellobiose | | cellobiose | epitope | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| syringic acid | | benzoic acids;
dimethoxybenzene;
phenols | plant metabolite | 2002 | 2023 | 11.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| methoxyhydroxyphenylglycol | | methoxybenzenes;
phenols | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 4-toluenesulfinic acid | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1,2-dichloroethylene | | chloroethenes | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,2,4-trimethylpentane | | alkane;
volatile organic compound | fuel additive;
nephrotoxin;
non-polar solvent | 1996 | 1998 | 27.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| ethyl chloroformate | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| malondialdehyde | | dialdehyde | biomarker | 1988 | 2022 | 21.7 | low | 6 | 2 | 18 | 14 | 8 | 1 |
| myristic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite | 1984 | 2021 | 21.4 | low | 1 | 4 | 17 | 14 | 10 | 1 |
| n-hexadecane | | long-chain alkane | non-polar solvent;
plant metabolite;
volatile oil component | 2002 | 2009 | 17.7 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| phenalen-1-one | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| neutral red | | hydrochloride | acid-base indicator;
dye;
two-colour indicator | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tristearin | | triacylglycerol 54:0 | Caenorhabditis elegans metabolite;
plant metabolite | 1993 | 2007 | 23.2 | low | 0 | 0 | 2 | 2 | 0 | 0 |
| tripalmitin | | triglyceride | | 2005 | 2007 | 18.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| glycidol | | epoxide;
primary alcohol | | 2007 | 2012 | 14.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| lignoceric acid | | straight-chain saturated fatty acid;
very long-chain fatty acid | Daphnia tenebrosa metabolite;
human metabolite;
plant metabolite;
volatile oil component | 1992 | 2016 | 19.2 | low | 0 | 0 | 2 | 0 | 2 | 0 |
| 4-methyl-1-(1-methylethyl)-3-cyclohexen-1-ol | | terpineol;
tertiary alcohol | anti-inflammatory agent;
antibacterial agent;
antineoplastic agent;
antioxidant;
antiparasitic agent;
apoptosis inducer;
plant metabolite;
volatile oil component | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glycerylphosphorylcholine | | glycerophosphocholine | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,3-dimethyl-2-butene | | | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| docusate | | diester;
organosulfonic acid | | 1989 | 1996 | 31.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| 3-hydroxyflavone | | flavonols;
monohydroxyflavone | | 2003 | 2014 | 16.4 | low | 0 | 0 | 0 | 5 | 2 | 0 |
| 1-phenyl-1,2-propanedione | | alpha-diketone;
aromatic ketone | plant metabolite | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| alpha-hydroxy-gamma-methylmercaptobutyric acid | | thia fatty acid | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| octadecane | | long-chain alkane | bacterial metabolite;
plant metabolite | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| triphenylphosphine | | benzenes;
tertiary phosphine | NMR chemical shift reference compound;
reducing agent | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-methylanthracene | | | | 2002 | 2002 | 22.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-anthramine | | anthracenamine | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| acetylcysteine | | acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid | antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary | 1995 | 2013 | 19.3 | low | 2 | 0 | 2 | 6 | 1 | 0 |
| 1,4-cyclohexadiene | | cyclohexadiene | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-nonanol | | nonanol;
secondary alcohol | bacterial metabolite;
flavouring agent;
pheromone;
plant metabolite;
rat metabolite;
volatile oil component | 2009 | 2009 | 15.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| docosane | | long-chain alkane | plant metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| erythromycin | | cyclic ketone;
erythromycin | | 1997 | 2015 | 18.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| nonadecanoic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | fungal metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dehydroepiandrosterone sulfate | | 17-oxo steroid;
steroid sulfate | EC 2.7.1.33 (pantothenate kinase) inhibitor;
human metabolite;
mouse metabolite | 2006 | 2017 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| isosorbide | | organic molecular entity | | 2021 | 2021 | 3.0 | low | 1 | 0 | 0 | 0 | 0 | 1 |
| 2-piperidone | | delta-lactam;
piperidones | EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methylnitrosourea | | N-nitrosoureas | alkylating agent;
carcinogenic agent;
mutagen;
teratogenic agent | 1995 | 2005 | 25.3 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| sterculic acid | | cyclopropenyl fatty acid;
long-chain fatty acid;
monounsaturated fatty acid | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cyclopentenone | | alicyclic ketone;
enone | Hsp70 inducer | 2000 | 2015 | 18.0 | low | 0 | 0 | 1 | 2 | 1 | 0 |
| 1-methylpyridinium | | methylpyridines | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| deoxycytidine | | pyrimidine 2'-deoxyribonucleoside | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1999 | 2020 | 16.8 | low | 0 | 0 | 1 | 3 | 2 | 0 |
| rhodamine 6g | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pentadecanoic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
food component;
human blood serum metabolite;
plant metabolite | 2014 | 2014 | 10.0 | low | 1 | 0 | 0 | 0 | 2 | 0 |
| ethambutol | | ethanolamines;
ethylenediamine derivative | antitubercular agent;
environmental contaminant;
xenobiotic | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tetradecyltrimethylammonium | | | | 1991 | 1997 | 30.7 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| durapatite | | | | 1986 | 2019 | 22.2 | low | 0 | 1 | 1 | 0 | 2 | 0 |
| potassium hydroxide | | alkali metal hydroxide | | 2002 | 2020 | 12.8 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| sodium hydroxide | | alkali metal hydroxide | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| zinc oxide | | zinc molecular entity | | 1993 | 2017 | 19.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| monolaurin | | 1-monoglyceride;
dodecanoate ester;
rac-1-monoacylglycerol | | 1982 | 2012 | 27.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| beta-pinene | | pinene | plant metabolite | 2009 | 2011 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| vancomycin | | glycopeptide | antibacterial drug;
antimicrobial agent;
bacterial metabolite | 2000 | 2018 | 13.3 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| d-alpha tocopherol | | alpha-tocopherol | algal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite | 1946 | 2023 | 24.7 | low | 13 | 29 | 83 | 66 | 36 | 3 |
| tocopherols | | | | 1995 | 2022 | 11.9 | low | 0 | 0 | 3 | 7 | 27 | 3 |
| diphenyldiselenide | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 9,10-epoxystearic acid | | epoxystearic acid | human metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ethyldimethylaminopropyl carbodiimide | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| paraquat | | organic cation | geroprotector;
herbicide | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| s,n,n'-tripropylthiocarbamate | | tertiary amine | | 2013 | 2018 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 2-tert-butylhydroquinone | | hydroquinones | food antioxidant | 2001 | 2015 | 15.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| amiloride | | aromatic amine;
guanidines;
organochlorine compound;
pyrazines | diuretic;
sodium channel blocker | 1992 | 2008 | 25.2 | low | 0 | 0 | 3 | 1 | 0 | 0 |
| aminocarb | | carbamate ester;
toluenes | acaricide;
agrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
molluscicide | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| betamethasone valerate | | 11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
fluorinated steroid;
primary alpha-hydroxy ketone;
steroid ester | anti-inflammatory drug | 2002 | 2002 | 22.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| diallyl disulfide | | organic disulfide | antifungal agent;
antineoplastic agent;
plant metabolite | 2001 | 2011 | 18.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| gamma-dodecalactone | | gamma-lactone | bacterial metabolite;
fungal metabolite;
volatile oil component | 2020 | 2020 | 4.0 | medium | 0 | 0 | 0 | 0 | 2 | 0 |
| fluorescein | | 2-benzofurans;
gamma-lactone;
organic heteropentacyclic compound;
oxaspiro compound;
polyphenol;
xanthene dye | fluorescent dye;
radioopaque medium | 1997 | 2008 | 20.8 | low | 3 | 0 | 1 | 4 | 0 | 0 |
| fucose | | fucopyranose;
L-fucose | Escherichia coli metabolite;
mouse metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trichloroepoxypropane | | | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| methional | | aliphatic sulfide | prostaglandin antagonist | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,2-bis(bromomethyl)-1,3-propanediol | | primary alcohol | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| sabinene | | thujene | plant metabolite | 2009 | 2011 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| sabinene | | thujene | plant metabolite | 2002 | 2023 | 12.2 | low | 0 | 0 | 0 | 4 | 0 | 2 |
| 1-octen-3-ol | | alkenyl alcohol;
medium-chain fatty alcohol | antimicrobial agent;
fungal metabolite;
insect attractant;
volatile oil component | 2003 | 2022 | 12.4 | low | 0 | 0 | 0 | 3 | 3 | 1 |
| mannose | | D-aldohexose;
D-mannose;
mannopyranose | metabolite | 2017 | 2022 | 4.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| dithiothreitol | | 1,4-dimercaptobutane-2,3-diol;
butanediols;
dithiol;
glycol;
thiol | chelator;
human metabolite;
reducing agent | 1989 | 2014 | 22.6 | low | 0 | 1 | 3 | 2 | 2 | 0 |
| ecdysone | | 14alpha-hydroxy steroid;
22-hydroxy steroid;
25-hydroxy steroid;
2beta-hydroxy steroid;
3beta-sterol;
6-oxo steroid;
ecdysteroid | prohormone | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| dimethyl trisulfide | | organic trisulfide | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| streptomycin | | antibiotic antifungal drug;
antibiotic fungicide;
streptomycins | antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| butylhydroxybutylnitrosamine | | nitrosamine;
primary alcohol | carcinogenic agent | 1995 | 2001 | 26.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| 2,2,4,4,6,8,8-heptamethylnonane | | alkane | | 1995 | 1995 | 29.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| trimetazidine | | aromatic amine | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| iodinated glycerol | | dioxolane | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| isostearate | | branched-chain saturated fatty acid;
long-chain fatty acid;
methyl-branched fatty acid | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| limonene | | cycloalkene;
p-menthadiene | human metabolite | 2004 | 2009 | 17.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| olsalazine | | azobenzenes;
dicarboxylic acid | non-steroidal anti-inflammatory drug;
prodrug | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| n-methylaspartate | | amino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound | neurotransmitter agent | 1996 | 2009 | 21.3 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| manganese | | elemental manganese;
manganese group element atom | Escherichia coli metabolite;
micronutrient | 1993 | 2014 | 19.8 | low | 0 | 0 | 2 | 1 | 2 | 0 |
| molybdenum | | chromium group element atom | micronutrient | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| palladium | | metal allergen;
nickel group element atom;
platinum group metal atom | | 1962 | 1962 | 62.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| platinum | | elemental platinum;
nickel group element atom;
platinum group metal atom | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| rhodium | | cobalt group element atom | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ruthenium | | iron group element atom;
platinum group metal atom | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| silver | | copper group element atom;
elemental silver | Escherichia coli metabolite | 1998 | 2019 | 18.2 | low | 0 | 0 | 4 | 6 | 5 | 0 |
| titanium | | titanium group element atom | | 2009 | 2013 | 13.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| argon | | monoatomic argon;
noble gas atom;
p-block element atom | food packaging gas;
neuroprotective agent | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cadmium | | cadmium molecular entity;
zinc group element atom | | 1995 | 2023 | 17.8 | low | 0 | 0 | 3 | 1 | 0 | 2 |
| cerium | | f-block element atom;
lanthanoid atom | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| chromium | | chromium group element atom;
metal allergen | micronutrient | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| gadolinium | | f-block element atom;
lanthanoid atom | | 1998 | 1999 | 25.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| gold | | copper group element atom;
elemental gold | | 2000 | 2021 | 13.0 | low | 0 | 0 | 1 | 1 | 1 | 1 |
| vanadium | | elemental vanadium;
vanadium group element atom | micronutrient | 1984 | 1992 | 35.3 | low | 0 | 1 | 2 | 0 | 0 | 0 |
| xenon | | monoatomic xenon;
noble gas atom;
p-block element atom | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cupric chloride | | copper molecular entity;
inorganic chloride | EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor | 1996 | 1996 | 28.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| mercuric chloride | | mercury coordination entity | sensitiser | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| acetylglucosamine | | N-acetyl-D-glucosamine | epitope | 1989 | 2000 | 29.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| galactosamine | | D-galactosamine;
primary amino compound | toxin | 1991 | 1992 | 32.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| sodium nitrate | | inorganic nitrate salt;
inorganic sodium salt | fertilizer;
NMR chemical shift reference compound | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hypochlorous acid | | chlorine oxoacid;
reactive oxygen species | EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
human metabolite | 1992 | 2013 | 21.1 | low | 0 | 0 | 3 | 3 | 2 | 0 |
| thionyl chloride | | chlorine molecular entity;
sulfinyl halide | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ferrous sulfate | | iron molecular entity;
metal sulfate | reducing agent | 1994 | 2005 | 24.8 | low | 0 | 0 | 2 | 2 | 0 | 0 |
| sodium pyrophosphate | | inorganic sodium salt | chelator;
food emulsifier;
food thickening agent | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| bromine | | diatomic bromine | | 1964 | 1993 | 45.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| zinc sulfate | | metal sulfate;
zinc molecular entity | fertilizer | 1994 | 2001 | 25.7 | low | 1 | 0 | 2 | 1 | 0 | 0 |
| chromic acid | | chromium oxoacid | oxidising agent | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| chromates | | chromium oxoanion;
divalent inorganic anion | oxidising agent | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| copper sulfate | | metal sulfate | emetic;
fertilizer;
sensitiser | 1992 | 2019 | 24.0 | low | 0 | 0 | 4 | 0 | 1 | 0 |
| silver nitrate | | inorganic nitrate salt;
silver salt | astringent | 1964 | 2019 | 28.7 | low | 0 | 1 | 0 | 1 | 1 | 0 |
| deuterium | | dihydrogen | | 1987 | 2022 | 19.0 | low | 1 | 2 | 13 | 10 | 13 | 2 |
| nitrous acid | | nitrogen oxoacid | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| silver iodide | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| deuterium oxide | | deuterated compound;
water | NMR solvent | 1996 | 2016 | 17.8 | low | 0 | 0 | 2 | 1 | 2 | 0 |
| glycerol 1-stearate | | 1-acylglycerol 18:0;
rac-1-monoacylglycerol | algal metabolite;
Caenorhabditis elegans metabolite | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| poloxalene | | epoxide | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ozone | | elemental molecule;
gas molecular entity;
reactive oxygen species;
triatomic oxygen | antiseptic drug;
disinfectant;
electrophilic reagent;
greenhouse gas;
mutagen;
oxidising agent;
tracer | 1963 | 2013 | 33.2 | low | 0 | 2 | 3 | 0 | 1 | 0 |
| sodium selenite | | inorganic sodium salt;
selenite salt | nutraceutical | 1993 | 2003 | 26.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| 4-chloro-7-nitrobenzofurazan | | benzoxadiazole;
C-nitro compound;
organochlorine compound | EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.6.1.3 (adenosinetriphosphatase) inhibitor;
fluorescent probe;
fluorochrome | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| trolamine salicylate | | | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| chrysotile | | | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ammonium chloride | | ammonium salt;
inorganic chloride | ferroptosis inhibitor | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ethionine | | S-ethylhomocysteine | antimetabolite;
carcinogenic agent | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| benzo(a)pyrene 7,8-dihydrodiol | | pyrenes | | 1992 | 1992 | 32.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| titanium dioxide | | titanium oxides | food colouring | 2009 | 2013 | 13.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| menthone | | menthone | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| salen | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tiletamine hydrochloride | | | | 1993 | 2012 | 24.3 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| phytanic acid | | branched-chain saturated fatty acid;
long-chain fatty acid;
methyl-branched fatty acid | | 2001 | 2013 | 15.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| ferric nitrilotriacetate | | iron chelate | carcinogenic agent;
mutagen | 1989 | 2005 | 24.7 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| tetradecanoylphorbol acetate | | acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester | antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator | 1982 | 2011 | 28.2 | low | 0 | 5 | 20 | 7 | 1 | 0 |
| fluorides | | halide anion;
monoatomic fluorine | | 1981 | 1981 | 43.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| 1-deoxynojirimycin | | 2-(hydroxymethyl)piperidine-3,4,5-triol;
piperidine alkaloid | anti-HIV agent;
anti-obesity agent;
bacterial metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
plant metabolite | 1990 | 1990 | 34.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| iodine | | halide anion;
monoatomic iodine | human metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| razoxane | | N-alkylpiperazine | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| phosphotyrosine | | L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid;
O(4)-phosphotyrosine | Escherichia coli metabolite;
immunogen | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| phenyl acetate | | benzenes;
phenyl acetates | | 1958 | 2022 | 35.0 | low | 0 | 24 | 9 | 13 | 6 | 2 |
| cetylpyridinium chloride anhydrous | | chloride salt;
organic chloride salt | antiseptic drug;
surfactant | 2004 | 2015 | 12.8 | low | 1 | 0 | 0 | 1 | 3 | 0 |
| ethyl hexanoate | | fatty acid ethyl ester;
hexanoate ester | metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| pyrrolidine | | azacycloalkane;
pyrrolidines;
saturated organic heteromonocyclic parent | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nonanal | | medium-chain fatty aldehyde;
n-alkanal;
saturated fatty aldehyde | human metabolite;
plant metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| tetradecanal | | 2,3-saturated fatty aldehyde;
long-chain fatty aldehyde | bacterial metabolite;
plant metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ursodeoxycholic acid | | bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid | human metabolite;
mouse metabolite | 1994 | 1994 | 30.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| pyrene | | ortho- and peri-fused polycyclic arene | fluorescent probe;
persistent organic pollutant | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-methoxyamphetamine | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 8-bromo cyclic adenosine monophosphate | | 3',5'-cyclic purine nucleotide;
adenyl ribonucleotide;
organobromine compound | antidepressant;
protein kinase agonist | 1989 | 2004 | 26.6 | low | 0 | 1 | 2 | 2 | 0 | 0 |
| 6-methoxy-2-naphthylacetic acid | | methoxynaphthalene;
monocarboxylic acid | drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
xenobiotic metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| transferrin | | | | 1982 | 2019 | 29.2 | low | 0 | 5 | 5 | 2 | 2 | 0 |
| n-methyl-n-(trimethylsilyl)trifluoroacetamide | | monocarboxylic acid amide;
N-silyl compound;
trifluoroacetamide | chromatographic reagent | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene | | | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| androstane-3,17-diol | | 17-hydroxy steroid;
3-hydroxy steroid;
androstanoid | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| alkenes | | | | 1992 | 2015 | 18.0 | low | 0 | 0 | 1 | 3 | 3 | 0 |
| glutamic acid | | glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical | 1995 | 2023 | 10.5 | low | 0 | 0 | 1 | 2 | 5 | 3 |
| azoxymethane | | | | 1984 | 2012 | 23.3 | low | 0 | 1 | 1 | 4 | 1 | 0 |
| torpedo | | | | 1997 | 2005 | 23.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| sodium azide | | inorganic sodium salt | antibacterial agent;
explosive;
mitochondrial respiratory-chain inhibitor;
mutagen | 1996 | 2011 | 22.0 | low | 0 | 0 | 2 | 1 | 1 | 0 |
| azides | | pseudohalide anion | mitochondrial respiratory-chain inhibitor | 1990 | 1997 | 29.7 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| norflurazone | | (trifluoromethyl)benzenes;
organochlorine compound;
pyridazinone;
secondary amino compound | agrochemical;
carotenoid biosynthesis inhibitor;
herbicide | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| vanadyl sulfate | | metal sulfate;
vanadium coordination entity | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ferrozine | | | | 2004 | 2007 | 18.0 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| 4-vinyl-2,6-dimethoxyphenol | | methoxybenzenes;
phenols | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 3,4,3',4'-tetrachlorobiphenyl | | dichlorobenzene;
tetrachlorobiphenyl | | 2001 | 2008 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| 4-ipomeanol | | aromatic ketone | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| paclitaxel | | taxane diterpenoid;
tetracyclic diterpenoid | antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent | 2009 | 2019 | 9.7 | low | 0 | 0 | 0 | 1 | 6 | 0 |
| promegestone | | 20-oxo steroid;
3-oxo-Delta(4) steroid | antineoplastic agent;
progesterone receptor agonist;
progestin | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ribavirin | | 1-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide | anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor | 1982 | 2023 | 21.5 | low | 0 | 1 | 0 | 0 | 0 | 1 |
| phorbol 12,13-dibutyrate | | butyrate ester;
phorbol ester;
tertiary alpha-hydroxy ketone | | 1988 | 2003 | 28.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| bezafibrate | | aromatic ether;
monocarboxylic acid amide;
monocarboxylic acid;
monochlorobenzenes | antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic | 1996 | 2008 | 22.1 | low | 0 | 0 | 3 | 4 | 0 | 0 |
| sq-11725 | | | | 2000 | 2000 | 24.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| 1-methyl-4-phenylpyridinium | | pyridinium ion | apoptosis inducer;
herbicide;
human xenobiotic metabolite;
neurotoxin | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ng-nitroarginine methyl ester | | alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound | EC 1.14.13.39 (nitric oxide synthase) inhibitor | 1997 | 2018 | 16.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid | | chromanol;
monocarboxylic acid;
phenols | antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radical scavenger;
Wnt signalling inhibitor | 1997 | 2020 | 16.8 | low | 0 | 0 | 4 | 8 | 7 | 0 |
| dh 990 | | | | 1984 | 1984 | 40.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| diisopropanolnitrosamine | | diol;
nitrosamine;
secondary alcohol | carcinogenic agent | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| enkephalin, methionine | | | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| dihydroalprenolol | | | | 1995 | 1997 | 28.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| nitrosobis(2-oxopropyl)amine | | ketone;
nitrosamine | carcinogenic agent | 1994 | 2006 | 25.7 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| captopril | | alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid | antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| bw-755c | | | | 1986 | 1988 | 37.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| colforsin | | acetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol | adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist | 1984 | 2001 | 28.0 | low | 0 | 1 | 4 | 2 | 0 | 0 |
| piroctone olamine | | | | 2022 | 2022 | 2.0 | low | 1 | 0 | 0 | 0 | 0 | 1 |
| fomesafen | | aromatic ether;
C-nitro compound;
monochlorobenzenes;
N-sulfonylcarboxamide;
organofluorine compound;
phenols | agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| lovastatin | | delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
polyketide;
statin (naturally occurring) | anticholesteremic drug;
antineoplastic agent;
Aspergillus metabolite;
prodrug | 1987 | 2023 | 18.6 | low | 0 | 1 | 3 | 2 | 2 | 1 |
| 2-amino-3-methylimidazo(4,5-f)quinoline | | imidazoquinoline | carcinogenic agent | 1992 | 1999 | 27.8 | low | 0 | 0 | 5 | 0 | 0 | 0 |
| n-nitrosobis(2-oxobutyl)amine | | | | 2000 | 2000 | 24.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| simvastatin | | delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
statin (semi-synthetic) | EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor;
EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor;
ferroptosis inducer;
geroprotector;
prodrug | 1997 | 2014 | 20.4 | low | 0 | 0 | 2 | 2 | 1 | 0 |
| idazoxan | | benzodioxine;
imidazolines | alpha-adrenergic antagonist | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pravastatin | | 3-hydroxy carboxylic acid;
carbobicyclic compound;
carboxylic ester;
hydroxy monocarboxylic acid;
secondary alcohol;
statin (semi-synthetic) | anticholesteremic drug;
environmental contaminant;
metabolite;
xenobiotic | 1993 | 1996 | 29.5 | low | 2 | 0 | 2 | 0 | 0 | 0 |
| mifepristone | | 3-oxo-Delta(4) steroid;
acetylenic compound;
tertiary amino compound | abortifacient;
contraceptive drug;
hormone antagonist;
synthetic oral contraceptive | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| fura-2 | | | | 1993 | 2011 | 23.3 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| adapalene | | adamantanes;
monocarboxylic acid;
naphthoic acid | dermatologic drug;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor;
non-steroidal anti-inflammatory drug | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| loxiglumide | | organic molecular entity | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| clopidogrel | | methyl ester;
monochlorobenzenes;
thienopyridine | anticoagulant;
P2Y12 receptor antagonist;
platelet aggregation inhibitor | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gemcitabine | | organofluorine compound;
pyrimidine 2'-deoxyribonucleoside | antimetabolite;
antineoplastic agent;
antiviral drug;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
environmental contaminant;
immunosuppressive agent;
photosensitizing agent;
prodrug;
radiosensitizing agent;
xenobiotic | 2012 | 2020 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| atorvastatin | | aromatic amide;
dihydroxy monocarboxylic acid;
monofluorobenzenes;
pyrroles;
statin (synthetic) | environmental contaminant;
xenobiotic | 2018 | 2022 | 4.0 | low | 1 | 0 | 0 | 0 | 1 | 1 |
| irinotecan | | carbamate ester;
delta-lactone;
N-acylpiperidine;
pyranoindolizinoquinoline;
ring assembly;
tertiary alcohol;
tertiary amino compound | antineoplastic agent;
apoptosis inducer;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
prodrug | 2019 | 2020 | 4.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| pobilukast | | | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| darglitazone | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| adenosine | | adenosines;
purines D-ribonucleoside | analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent | 1984 | 1992 | 36.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| n-butyllithium | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sudan black b | | azobenzenes;
bis(azo) compound;
perimidines | histological dye | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1-octen-3-one | | olefinic compound | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-n-butylphthalide | | benzofurans | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pyranine | | organic sodium salt | fluorochrome | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| potassium superoxide | | | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| vanadates | | trivalent inorganic anion;
vanadium oxoanion | EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor | 1984 | 2002 | 32.2 | low | 0 | 2 | 1 | 1 | 0 | 0 |
| ruthenium chloride (rucl3) | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzylaminopurine | | 6-aminopurines | cytokinin;
plant metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| caloreen | | | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| trazodone hydrochloride | | hydrochloride | adrenergic antagonist;
antidepressant;
H1-receptor antagonist;
sedative;
serotonin uptake inhibitor | 1963 | 2022 | 20.8 | low | 0 | 3 | 1 | 4 | 8 | 1 |
| methylprednisolone aceponate | | corticosteroid hormone | | 1995 | 1995 | 29.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| 3,4,5,3',4'-pentachlorobiphenyl | | pentachlorobiphenyl;
trichlorobenzene | | 1997 | 1999 | 26.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| glucose, (beta-d)-isomer | | D-glucopyranose | epitope;
mouse metabolite | 1987 | 2018 | 25.2 | low | 0 | 3 | 4 | 3 | 1 | 0 |
| mevastatin | | 2-pyranones;
carboxylic ester;
hexahydronaphthalenes;
polyketide;
statin (naturally occurring) | antifungal agent;
apoptosis inducer;
EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor;
fungal metabolite;
Penicillium metabolite | 1987 | 2003 | 29.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| ursolic acid | | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | geroprotector;
plant metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cyclen | | azacycloalkane;
crown amine;
saturated organic heteromonocyclic parent | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| thiazolyl blue | | organic bromide salt | colorimetric reagent;
dye | 2000 | 2008 | 20.7 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| thymidine 5'-triphosphate | | pyrimidine 2'-deoxyribonucleoside 5'-triphosphate;
thymidine phosphate | Escherichia coli metabolite;
mouse metabolite | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 3-methylhistidine | | L-histidine derivative;
non-proteinogenic L-alpha-amino acid;
zwitterion | human metabolite;
Saccharomyces cerevisiae metabolite | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| betulinic acid | | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| allicin | | botanical anti-fungal agent;
sulfoxide | antibacterial agent | 2011 | 2018 | 9.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| epigallocatechin gallate | | flavans;
gallate ester;
polyphenol | antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite | 2003 | 2021 | 11.5 | low | 0 | 0 | 0 | 3 | 1 | 2 |
| n-acetylaspartic acid | | N-acetyl-L-amino acid;
N-acyl-L-aspartic acid | antioxidant;
human metabolite;
mouse metabolite;
nutraceutical;
rat metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fluorexon | | xanthene dye | fluorochrome | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cholesteryl succinate | | cholestane ester;
dicarboxylic acid monoester;
hemisuccinate | detergent | 1993 | 2017 | 21.0 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| gallocatechol | | gallocatechin | antioxidant;
metabolite;
radical scavenger | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| xanthotoxol | | 8-hydroxyfurocoumarin | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 25-hydroxycholesterol | | 25-hydroxy steroid;
oxysterol | human metabolite | 1987 | 1987 | 37.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| 10,10'-dimethyl-9,9'-biacridinium | | | | 1984 | 1993 | 35.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| leucine methyl ester | | alpha-amino acid ester;
L-leucine derivative;
methyl ester | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| bathocuproine | | | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pyrrolidine dithiocarbamate | | dithiocarbamic acids;
pyrrolidines | anticonvulsant;
antineoplastic agent;
geroprotector;
neuroprotective agent;
NF-kappaB inhibitor;
radical scavenger | 2003 | 2007 | 19.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| peroxynitric acid | | nitrogen oxoacid | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| glutathione disulfide | | glutathione derivative;
organic disulfide | Escherichia coli metabolite;
mouse metabolite | 1992 | 2003 | 26.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| 12-(9-anthroyl)stearic acid | | | | 1991 | 1991 | 33.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| cephalosporin c | | cephalosporin | fungal metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| raxofelast | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| telmisartan | | benzimidazoles;
biphenyls;
carboxybiphenyl | angiotensin receptor antagonist;
antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
environmental contaminant;
xenobiotic | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nicanartine | | | | 1998 | 1998 | 26.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| methacycline | | 1,2-diglyceride | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| salicylhydroxamic acid | | hydroxamic acid;
phenols | antibacterial drug;
EC 1.11.2.2 (myeloperoxidase) inhibitor;
EC 3.5.1.5 (urease) inhibitor;
trypanocidal drug | 1986 | 2000 | 31.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| 1,7-phenanthroline | | phenanthroline | | 1986 | 2023 | 22.0 | low | 0 | 1 | 1 | 0 | 0 | 1 |
| triazoles | | 1,2,3-triazole | | 1998 | 2011 | 21.0 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| isopimpinellin | | psoralens | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| rubrene | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| duroquinone | | 1,4-benzoquinones | | 1983 | 2004 | 30.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| delphinidin | | anthocyanidin chloride | | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| sesamol | | benzodioxoles | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1,2-dithiol-3-thione | | 1,2-dithiole | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| silver | | | | 1994 | 1999 | 27.5 | low | 1 | 0 | 2 | 0 | 0 | 0 |
| ubiquinone-o | | ubiquinones | Escherichia coli metabolite;
human metabolite | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| beta-hydroxyisovaleric acid | | 3-hydroxy monocarboxylic acid | human metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-hydroxy-4-methoxybenzaldehyde | | methoxybenzenes;
phenols | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cromakalim | | | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| asparkam | | | | 1985 | 1985 | 39.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| tyloxapol | | | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| masoprocol | | nordihydroguaiaretic acid | antineoplastic agent;
hypoglycemic agent;
lipoxygenase inhibitor;
metabolite | 1986 | 2004 | 29.1 | low | 0 | 4 | 13 | 4 | 0 | 0 |
| trichlorosucrose | | disaccharide derivative;
organochlorine compound | environmental contaminant;
sweetening agent;
xenobiotic | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| aceclofenac | | amino acid;
carboxylic ester;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound | EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-tetradecylglycidic acid | | | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| methotrimeprazine | | phenothiazines;
tertiary amine | anticoronaviral agent;
cholinergic antagonist;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
non-narcotic analgesic;
phenothiazine antipsychotic drug;
serotonergic antagonist | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sesamin | | benzodioxoles;
furofuran;
lignan | antineoplastic agent;
neuroprotective agent;
plant metabolite | 1998 | 2003 | 23.0 | low | 0 | 0 | 2 | 3 | 0 | 0 |
| lycorine | | indolizidine alkaloid | anticoronaviral agent;
antimalarial;
plant metabolite;
protein synthesis inhibitor | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cyclopentenyl cytosine | | | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| nicosulfuron | | N-sulfonylurea;
pyridines;
pyrimidines | environmental contaminant;
herbicide;
xenobiotic | 2007 | 2008 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| strictinin | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| brusatol | | triterpenoid | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid | | harmala alkaloid | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| perfluorooctane sulfonic acid | | perfluoroalkanesulfonic acid | antilipemic drug;
persistent organic pollutant | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n-acetylhistidine | | L-histidine derivative;
N-acetyl-L-amino acid;
N-acetylhistidine | animal metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 9-oxononanoic acid | | aldehydic acid;
medium-chain fatty acid;
omega-oxo fatty acid | EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor | 2013 | 2013 | 11.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-hydroxybenzotriazole | | benzotriazoles | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| octadecyl palmitate | | hexadecanoate ester;
wax ester | coral metabolite;
cosmetic | 1953 | 1963 | 66.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| 6-carboxyfluorescein | | monocarboxylic acid | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| benzoyltyrosine ethyl ester | | benzamides;
ethyl ester;
L-tyrosine derivative;
phenols | chromogenic compound | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| rosiglitazone | | aminopyridine;
thiazolidinediones | EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
insulin-sensitizing drug | 1995 | 2018 | 17.6 | low | 0 | 0 | 3 | 5 | 4 | 0 |
| n-hydroxysuccinimide | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3,7-dimethyl-7-octen-1-ol | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-bromopalmitate | | 2-bromocarboxylic acid;
bromo fatty acid;
long-chain fatty acid;
straight-chain fatty acid | fatty acid oxidation inhibitor | 1987 | 2009 | 23.7 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| bexarotene | | benzoic acids;
naphthalenes;
retinoid | antineoplastic agent | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2-(4-toluidino)-6-naphthalenesulfonic acid | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3,4-dihydroxyphenylethanol | | catechols;
primary alcohol | antineoplastic agent;
antioxidant;
metabolite | 2006 | 2016 | 13.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| biocytin | | azabicycloalkane;
L-alpha-amino acid zwitterion;
L-lysine derivative;
monocarboxylic acid amide;
non-proteinogenic L-alpha-amino acid;
thiabicycloalkane;
ureas | mouse metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| clarithromycin | | macrolide antibiotic | antibacterial drug;
environmental contaminant;
protein synthesis inhibitor;
xenobiotic | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hexylphosphonic acid diethyl ester | | | | 2019 | 2019 | 5.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| s-methyl benzo(1,2,3)thiadiazole-7-carbothioate | | benzothiadiazole;
thioester | antifungal agrochemical;
plant activator;
profungicide | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| coenzyme a | | adenosine 3',5'-bisphosphate | coenzyme;
Escherichia coli metabolite;
mouse metabolite | 1963 | 2022 | 41.0 | low | 0 | 8 | 1 | 1 | 0 | 1 |
| 7,8-dihydromethysticin | | 2-pyranones;
aromatic ether | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| va 061 | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| mebeverine | | | | 2011 | 2018 | 9.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| nicotine | | 3-(1-methylpyrrolidin-2-yl)pyridine | anxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic | 2005 | 2008 | 17.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| nsc-172755 | | | | 2018 | 2018 | 6.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| hexyl nicotinate | | | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| fibrinogen | | iditol | fungal metabolite | 1987 | 2012 | 25.8 | low | 1 | 1 | 3 | 0 | 1 | 0 |
| 7-ketocholesterol | | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
7-oxo steroid;
cholestanoid | neuroprotective agent | 2005 | 2017 | 14.0 | low | 0 | 0 | 0 | 3 | 2 | 0 |
| 2-tyrosine | | non-proteinogenic alpha-amino acid;
phenols;
phenylalanine derivative | | 2000 | 2000 | 24.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| 2,2'-azobis(2,4-dimethylvaleronitrile) | | | | 1994 | 2005 | 24.6 | low | 0 | 0 | 3 | 2 | 0 | 0 |
| glycidamide | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-phenylamino-1,2-propanediol | | glycol;
secondary amine | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| homocysteine | | amino acid zwitterion;
homocysteine;
serine family amino acid | fundamental metabolite;
mouse metabolite | 2006 | 2018 | 9.0 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| methylglucoside | | | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| oryzemate | | 1,2-benzisothiazole;
aromatic ether;
benzothiazole fungicide;
sulfone | antifungal agrochemical;
plant activator | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| acetylsalicylic acid lysinate | | | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| delta-tocopherol | | tocopherol;
vitamin E | food antioxidant;
plant metabolite | 2014 | 2018 | 8.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| gamma-tocopherol | | tocopherol;
vitamin E | algal metabolite;
food antioxidant;
plant metabolite | 2004 | 2020 | 11.2 | low | 0 | 0 | 0 | 2 | 4 | 0 |
| nepetalactone | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| totarol | | diterpenoid | metabolite | 1996 | 1997 | 27.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| annatto | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| n(alpha)-acetyllysine | | acetyl-L-lysine;
amino acid zwitterion | human metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glycidyl nitrate | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| glycylsarcosine | | dipeptide zwitterion;
dipeptide | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| quinupramine | | dibenzooxazepine | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nsc 153174 | | | | 1962 | 1962 | 62.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| cv 6504 | | | | 1996 | 2001 | 25.0 | high | 1 | 0 | 2 | 1 | 0 | 0 |
| stearoyl-coenzyme a | | 11,12-saturated fatty acyl-CoA;
long-chain fatty acyl-CoA | Escherichia coli metabolite;
mouse metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pyrimidine dimers | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dehydroabietic acid | | abietane diterpenoid;
carbotricyclic compound;
monocarboxylic acid | allergen;
metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glucuronic acid | | D-glucuronic acid | algal metabolite | 1999 | 2015 | 14.7 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| 2,6-dichloroisonicotinic acid | | monocarboxylic acid;
organochlorine compound;
pyridines | EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 2-bromostearic acid | | | | 1995 | 1995 | 29.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| 2,2,5,7,8-pentamethyl-1-hydroxychroman | | | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| isosteviol | | diterpenoid | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| arctiin | | glycoside;
lignan | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| karanjin | | extended flavonoid | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1,3-dioctadecanoylglycerol | | | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| cobalt | | cobalt group element atom;
metal allergen | micronutrient | 1961 | 2022 | 26.5 | low | 0 | 2 | 1 | 1 | 1 | 1 |
| hydrogen sulfite | | sulfur oxoanion | human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| yttrium radioisotopes | | | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| u 73122 | | aromatic ether;
aza-steroid;
maleimides | EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor | 2008 | 2015 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| vitamin b 6 | | | | 1951 | 2006 | 42.4 | low | 0 | 4 | 0 | 4 | 0 | 0 |
| 1,4-dihydropyridine | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| sr141716 | | amidopiperidine;
carbohydrazide;
dichlorobenzene;
monochlorobenzenes;
pyrazoles | anti-obesity agent;
appetite depressant;
CB1 receptor antagonist | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| u 74006f | | corticosteroid hormone | | 1989 | 1994 | 32.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| diacetyldichlorofluorescein | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| u 74389f | | | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1h-imidazole | | ether;
imidazoles;
monomethoxybenzene | TRP channel blocker | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| laurdan | | | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| prolinedithiocarbamate | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dihydrorhodamine 123 | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cyanates | | | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1,n(6)-ethenodeoxyadenosine | | purines | | 1999 | 2007 | 21.7 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| thiamethoxam | | 1,3-thiazoles;
2-nitroguanidine derivative;
organochlorine compound;
oxadiazane | antifeedant;
carcinogenic agent;
environmental contaminant;
neonicotinoid insectide;
xenobiotic | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| u 78517f | | | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 22-hydroxycholesterol | | cholanoid | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| propionylcarnitine | | O-acylcarnitine | analgesic;
antirheumatic drug;
cardiotonic drug;
human metabolite;
peripheral nervous system drug | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 3,n(4)-ethenodeoxycytidine | | | | 1999 | 2007 | 21.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| 1,n(2)-propanodeoxyguanosine | | carbohydrate derivative;
nucleobase-containing molecular entity | | 1999 | 2002 | 23.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| procyanidin | | proanthocyanidin | | 2002 | 2014 | 16.6 | low | 0 | 0 | 0 | 4 | 1 | 0 |
| epicatechin gallate | | catechin;
gallate ester;
polyphenol | EC 3.2.1.1 (alpha-amylase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
metabolite | 2007 | 2008 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| u 74500a | | | | 1989 | 1994 | 32.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| parinaric acid | | octadecatetraenoic acid | | 1984 | 1996 | 31.8 | low | 0 | 1 | 5 | 0 | 0 | 0 |
| dihydrocapsaicin | | capsaicinoid | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| proanthocyanidin | | | | 2002 | 2008 | 19.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| 1-hexadecyl-2-acetyl-glycero-3-phosphocholine | | 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine | antihypertensive agent;
beta-adrenergic antagonist;
bronchoconstrictor agent;
hematologic agent;
vasodilator agent | 1992 | 2004 | 26.4 | low | 0 | 0 | 6 | 1 | 0 | 0 |
| deoxyglucose | | | | 1988 | 2005 | 25.3 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| 5,6-dihydroxyindole | | dihydroxyindole | mouse metabolite | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 2,3-bis(3'-hydroxybenzyl)butyrolactone | | lignan | | 1999 | 2017 | 16.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| valerates | | short-chain fatty acid anion;
straight-chain saturated fatty acid anion | plant metabolite | 1990 | 2006 | 26.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| thromboxanes | | | | 1981 | 2008 | 32.1 | low | 1 | 9 | 6 | 4 | 0 | 0 |
| chymosin | | | | 2009 | 2013 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| ruthenium tetraoxide | | | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| cucurbitacins | | 11-oxo steroid | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| caprylates | | fatty acid anion 8:0;
straight-chain saturated fatty acid anion | human metabolite;
Saccharomyces cerevisiae metabolite | 1963 | 2016 | 28.7 | low | 0 | 8 | 4 | 9 | 7 | 0 |
| 5,6-dihydroxy-2-indolylcarboxylic acid | | dihydroxyindole | mouse metabolite | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| tris(2-carboxyethyl)phosphine | | phosphine derivative;
tricarboxylic acid | reducing agent | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| emeriamine | | | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 12-(9-anthroyloxy)stearic acid | | | | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| protoporphyrinogen | | porphyrinogens | Escherichia coli metabolite;
mouse metabolite | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| phytosphingosine | | amino alcohol;
sphingoid;
triol | mouse metabolite;
Saccharomyces cerevisiae metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dansylsarcosine | | | | 1993 | 2011 | 22.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| chlorodimedone | | | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| florox reagent | | | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3,7,12-trihydroxycholestan-26-oic acid | | 12alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7alpha-hydroxy steroid;
hydroxy monocarboxylic acid;
steroid acid | human metabolite | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| phenoxy radical | | organic radical | | 1989 | 1998 | 30.0 | low | 0 | 1 | 3 | 0 | 0 | 0 |
| carbene | | carbene;
methanediyl | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| peroxynitrous acid | | nitrogen oxoacid | | 2000 | 2009 | 19.8 | low | 0 | 0 | 1 | 3 | 0 | 0 |
| 2-palmitoylglycerol | | 2-acylglycerol 16:0 | algal metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fullerene c60 | | fullerene | geroprotector | 1999 | 2012 | 18.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| 2,3-bis(3'-hydroxybenzyl)butane-1,4-diol | | lignan | | 1999 | 2016 | 16.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| n(6)-carboxymethyllysine | | L-lysine derivative;
non-proteinogenic L-alpha-amino acid | antigen | 2013 | 2023 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| glycerophosphoethanolamine | | phosphoethanolamine;
sn-glycerol 3-phosphates | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| f-chemotactic peptide | | | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone | | dichlorobenzene;
differentiation-inducing factor;
monomethoxybenzene;
resorcinols | eukaryotic metabolite;
signalling molecule | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| hydroxycitric acid | | carbonyl compound | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| dodecyloctaethyleneglycol monoether | | hydroxypolyether | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pristanic acid | | branched-chain saturated fatty acid;
long-chain fatty acid;
methyl-branched fatty acid | human metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 27-hydroxycholesterol | | 26-hydroxycholesterol | apoptosis inducer;
human metabolite;
mouse metabolite;
neuroprotective agent | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid | | dicarboxylic acid;
furoic acid | human metabolite;
uremic toxin | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tetrahydrocurcumin | | beta-diketone;
diarylheptanoid;
polyphenol | metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glucogallin | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glutamyl-valyl-asparaginyl-phenylalanyl-seryl-prolyl-asparaginyl-tryptophanamide | | | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| glutamyl-leucyl-threonyl-phenylalanyl-threonyl-prolyl-asparaginyl-tryptophanamide | | | | 1997 | 1997 | 27.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| glycerophosphoinositol 4,5-bisphosphate | | | | 1994 | 2000 | 27.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| methotrexate | | dicarboxylic acid;
monocarboxylic acid amide;
pteridines | abortifacient;
antimetabolite;
antineoplastic agent;
antirheumatic drug;
dermatologic drug;
DNA synthesis inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
immunosuppressive agent | 1997 | 2013 | 19.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| 8-chloro-4-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinolin-3(2h)-one | | | | 2007 | 2007 | 17.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| 3,4,5-tri-o-galloylquinic acid | | | | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| s 20928 | | | | 1999 | 2001 | 24.0 | medium | 0 | 0 | 1 | 1 | 0 | 0 |
| rg 6866 | | | | 1992 | 1992 | 32.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| bwa 137c | | | | 1988 | 1988 | 36.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| omega-n-methylarginine | | amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 13-hydroxyeicosatetraenoic acid | | | | 1998 | 1998 | 26.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| 15-hydroxyeicosatrienoic acid | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| xylose | | D-xylose | | 2004 | 2012 | 16.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| duroquinol | | hydroquinones;
methylbenzene | bacterial xenobiotic metabolite;
volatile oil component | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| phytol | | | | 2003 | 2005 | 20.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| proline | | amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid | algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 1991 | 2020 | 13.0 | low | 0 | 0 | 1 | 2 | 5 | 0 |
| cucurbitaceae | | | | 2001 | 2020 | 11.7 | low | 0 | 0 | 0 | 2 | 4 | 0 |
| docetaxel anhydrous | | secondary alpha-hydroxy ketone;
tetracyclic diterpenoid | antimalarial;
antineoplastic agent;
photosensitizing agent | 2013 | 2022 | 6.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| 1,3-dicapryloylglycerol | | 1,3-diglyceride | Brassica napus metabolite;
excipient | 2001 | 2001 | 23.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| phorbols | | diterpene;
terpenoid fundamental parent | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ly 311727 | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| naproxen | | methoxynaphthalene;
monocarboxylic acid | antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
gout suppressant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| hydroxyl radical | | oxygen hydride;
oxygen radical;
reactive oxygen species | | 1985 | 2023 | 17.8 | low | 0 | 2 | 7 | 22 | 12 | 1 |
| singlet oxygen | | chalcogen;
monoatomic oxygen;
nonmetal atom | macronutrient | 1988 | 2015 | 19.0 | low | 0 | 1 | 3 | 5 | 5 | 0 |
| eritadenine | | | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| fenton's reagent | | | | 1992 | 2016 | 18.2 | low | 0 | 0 | 1 | 2 | 2 | 0 |
| cerous chloride | | cerium coordination entity | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| platycodin d | | triterpenoid saponin | metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| pyrenedecanoic acid | | | | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ferric thiocyanate | | | | 1999 | 2015 | 15.3 | medium | 0 | 0 | 1 | 4 | 4 | 0 |
| dehydrodieugenol | | biphenyls | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| anacardic acid | | hydroxy monocarboxylic acid;
hydroxybenzoic acid | anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
apoptosis inducer;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
neuroprotective agent;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| trimethylsilyldiazomethane | | | | 2000 | 2001 | 23.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| n-acetyl-n-formyl-5-methoxykynurenamine | | aromatic ketone | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| biotin | | biotins;
vitamin B7 | coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite | 1985 | 2000 | 33.8 | low | 0 | 3 | 1 | 0 | 0 | 0 |
| angiotensin ii | | amino acid zwitterion;
angiotensin II | human metabolite | 1983 | 2020 | 22.9 | low | 0 | 2 | 1 | 2 | 2 | 0 |
| campesterol | | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
C28-steroid;
phytosterols | mouse metabolite | 2002 | 2016 | 14.0 | low | 0 | 0 | 0 | 4 | 4 | 0 |
| 3-n-butyl-4,5-dihydrophthalide | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid | | prostanoid | | 2016 | 2016 | 8.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| lignin | | | | 1999 | 2016 | 14.6 | low | 0 | 0 | 1 | 1 | 3 | 0 |
| sb 203580 | | imidazoles;
monofluorobenzenes;
pyridines;
sulfoxide | EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| homocysteic acid | | homocysteic acid | NMDA receptor agonist | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| organophosphonates | | divalent inorganic anion;
phosphite ion | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| limonin | | epoxide;
furans;
hexacyclic triterpenoid;
lactone;
limonoid;
organic heterohexacyclic compound | inhibitor;
metabolite;
volatile oil component | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aflatoxin b1 | | aflatoxin;
aromatic ether;
aromatic ketone | carcinogenic agent;
human metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| octadeca-5,8-dienoic acid | | | | 1986 | 2021 | 20.5 | high | 0 | 1 | 0 | 0 | 0 | 1 |
| 3-hydroxyterphenyllin | | catechols;
dimethoxybenzene;
para-terphenyl | Aspergillus metabolite | 2001 | 2001 | 23.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| tetranorprostanedioic acid | | | | 1982 | 2003 | 34.0 | high | 0 | 2 | 0 | 1 | 0 | 0 |
| cohumulone | | secondary alpha-hydroxy ketone | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fe(iii)-edta | | iron coordination entity | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aspalatone | | | | 2001 | 2001 | 23.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| deferasirox | | benzoic acids;
monocarboxylic acid;
phenols;
triazoles | iron chelator | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| cholic acid | | 12alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7alpha-hydroxy steroid;
bile acid;
C24-steroid;
trihydroxy-5beta-cholanic acid | human metabolite;
mouse metabolite | 1985 | 2012 | 24.0 | low | 0 | 1 | 1 | 1 | 1 | 0 |
| deoxycholic acid | | bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid | human blood serum metabolite | 1990 | 2007 | 25.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| estradiol 3-benzoate | | 17beta-hydroxy steroid;
benzoate ester | estrogen receptor agonist;
xenoestrogen | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| cortisone | | 11-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | human metabolite;
mouse metabolite | 1955 | 1958 | 67.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| 6-octadecynoic acid | | octadecynoic acid | | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-nitrotyrosine | | 2-nitrophenols;
C-nitro compound;
nitrotyrosine;
non-proteinogenic alpha-amino acid | | 2000 | 2009 | 20.2 | low | 0 | 0 | 1 | 3 | 0 | 0 |
| 5-hydroxymethylfurfural | | arenecarbaldehyde;
furans;
primary alcohol | indicator;
Maillard reaction product | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| stigmastanol | | 3-hydroxy steroid;
phytosterols | anticholesteremic drug;
plant metabolite | 2009 | 2014 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| lanosterol | | 14alpha-methyl steroid;
3beta-sterol;
tetracyclic triterpenoid | bacterial metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 2-hydroxyestradiol | | 17beta-hydroxy steroid;
2-hydroxy steroid | carcinogenic agent;
human metabolite;
metabolite;
mouse metabolite;
prodrug | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| anisomycin | | monohydroxypyrrolidine;
organonitrogen heterocyclic antibiotic | anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
antiparasitic agent;
bacterial metabolite;
DNA synthesis inhibitor;
protein synthesis inhibitor | 1993 | 2008 | 23.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| benzofurans | | | | 1999 | 2016 | 16.0 | low | 0 | 0 | 1 | 4 | 2 | 0 |
| lupeol | | pentacyclic triterpenoid;
secondary alcohol | anti-inflammatory drug;
plant metabolite | 1998 | 1999 | 25.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| calendula | | | | 2001 | 2017 | 18.0 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| pifithrin mu | | benzenes | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 10-ketostearic acid | | long-chain fatty acid | | 2002 | 2020 | 14.7 | high | 0 | 0 | 0 | 2 | 1 | 0 |
| colupulone | | beta-bitter acid | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sakacin a | | aspartic acid derivative | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| dihydropyridines | | | | 1999 | 2008 | 20.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| leupeptins | | | | 2006 | 2012 | 15.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| lithium chloride | | inorganic chloride;
lithium salt | antimanic drug;
geroprotector | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| s-adenosylhomocysteine | | adenosines;
amino acid zwitterion;
homocysteine derivative;
homocysteines;
organic sulfide | cofactor;
EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor;
EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor;
epitope;
fundamental metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glycogen | | | | 1965 | 2019 | 23.4 | low | 0 | 1 | 1 | 6 | 1 | 0 |
| arabinose | | L-arabinose | Escherichia coli metabolite;
mouse metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n-acetylneuraminic acid | | N-acetylneuraminic acids | antioxidant;
bacterial metabolite;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
human metabolite;
mouse metabolite | 1984 | 1989 | 37.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| bradykinin | | oligopeptide | human blood serum metabolite;
vasodilator agent | 1981 | 2010 | 32.8 | low | 0 | 4 | 1 | 1 | 0 | 0 |
| amylopectin | | | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| glucosamine | | D-glucosamine | Escherichia coli metabolite;
geroprotector;
mouse metabolite | 1985 | 2022 | 22.8 | low | 1 | 1 | 1 | 1 | 0 | 1 |
| elastin | | oligopeptide | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| carnosine | | amino acid zwitterion;
dipeptide | anticonvulsant;
antineoplastic agent;
antioxidant;
Daphnia magna metabolite;
geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent | 1994 | 1995 | 29.3 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| mevalonic acid | | 3,5-dihydroxy-3-methylpentanoic acid | | 1963 | 2008 | 36.4 | low | 0 | 5 | 2 | 2 | 0 | 0 |
| naringenin | | (2S)-flavan-4-one;
naringenin | expectorant;
plant metabolite | 2010 | 2016 | 11.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| oxytocin | | heterodetic cyclic peptide;
peptide hormone | oxytocic;
vasodilator agent | 1993 | 2020 | 18.6 | low | 0 | 0 | 1 | 5 | 2 | 0 |
| pantetheine | | pantetheines;
thiol | human metabolite;
metabolite;
mouse metabolite | 1989 | 1991 | 34.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| inositol 1,4,5-trisphosphate | | myo-inositol trisphosphate | mouse metabolite | 1995 | 2014 | 16.2 | low | 0 | 0 | 1 | 0 | 3 | 0 |
| ouabain | | 11alpha-hydroxy steroid;
14beta-hydroxy steroid;
5beta-hydroxy steroid;
alpha-L-rhamnoside;
cardenolide glycoside;
steroid hormone | anti-arrhythmia drug;
cardiotonic drug;
EC 2.3.3.1 [citrate (Si)-synthase] inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
ion transport inhibitor;
plant metabolite | 1986 | 1992 | 35.0 | low | 1 | 3 | 2 | 0 | 0 | 0 |
| casein hydrolysate | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| taxifolin | | taxifolin | metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tartaric acid | | tartaric acid | Escherichia coli metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pentostatin | | coformycins | antimetabolite;
antineoplastic agent;
Aspergillus metabolite;
bacterial metabolite;
EC 3.5.4.4 (adenosine deaminase) inhibitor | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| mannosamine | | D-mannosamine | | 1985 | 2008 | 27.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| inositol 3-phosphate | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dehydroascorbic acid | | dehydroascorbic acid;
vitamin C | coenzyme;
mouse metabolite | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| cellulase | | cellotriose | | 2008 | 2009 | 15.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| monensin | | cyclic hemiketal;
monocarboxylic acid;
polyether antibiotic;
spiroketal | antifungal agent;
coccidiostat;
ionophore | 1999 | 2022 | 16.2 | low | 1 | 0 | 1 | 2 | 1 | 1 |
| miglitol | | piperidines | | 1990 | 1990 | 34.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| mometasone furoate | | 11beta-hydroxy steroid;
2-furoate ester;
20-oxo steroid;
3-oxo-Delta(1),Delta(4)-steroid;
organochlorine compound;
steroid ester | anti-allergic agent;
anti-inflammatory drug | 2019 | 2019 | 5.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| ryanodine | | | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| silychristin | | 1-benzofurans;
aromatic ether;
flavonolignan;
polyphenol;
secondary alpha-hydroxy ketone | lipoxygenase inhibitor;
metabolite;
prostaglandin antagonist;
radical scavenger | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pulegone | | p-menth-4(8)-en-3-one | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| gingerol | | beta-hydroxy ketone;
guaiacols | antineoplastic agent;
plant metabolite | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| lignans | | | | 1998 | 2017 | 18.9 | low | 0 | 0 | 3 | 4 | 3 | 0 |
| n-formylmethionine leucyl-phenylalanine | | tripeptide | | 1987 | 2002 | 29.8 | low | 1 | 1 | 9 | 1 | 0 | 0 |
| petunidin-3-glucoside | | anthocyanin cation;
aromatic ether;
beta-D-glucoside | antioxidant;
metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| malvidin-3-glucoside | | anthocyanin cation;
aromatic ether;
beta-D-glucoside | metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| betadex | | cyclodextrin | | 2002 | 2019 | 14.8 | low | 0 | 0 | 0 | 4 | 2 | 0 |
| e-z cinnamic acid | | cinnamic acid | plant metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| ergosterol | | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols | fungal metabolite;
Saccharomyces cerevisiae metabolite | 1998 | 2022 | 11.9 | low | 0 | 0 | 1 | 3 | 6 | 1 |
| tretinoin | | retinoic acid;
vitamin A | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
AP-1 antagonist;
human metabolite;
keratolytic drug;
retinoic acid receptor agonist;
retinoid X receptor agonist;
signalling molecule | 1987 | 2018 | 26.8 | low | 1 | 2 | 3 | 0 | 1 | 0 |
| arachidonic acid | | icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid | Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite | 1947 | 2023 | 25.8 | low | 39 | 234 | 334 | 205 | 177 | 32 |
| alpha-cyclodextrin | | cyclodextrin | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fumaric acid | | butenedioic acid | food acidity regulator;
fundamental metabolite;
geroprotector | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| resveratrol | | resveratrol | antioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger | 2001 | 2023 | 11.4 | low | 0 | 0 | 0 | 3 | 4 | 2 |
| retinol | | retinol;
vitamin A | human metabolite;
mouse metabolite;
plant metabolite | 1951 | 2023 | 28.5 | low | 4 | 11 | 14 | 10 | 7 | 2 |
| cyanoginosin lr | | microcystin | bacterial metabolite;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
environmental contaminant;
xenobiotic | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| docosahexaenoate | | docosahexaenoic acid;
omega-3 fatty acid | algal metabolite;
antineoplastic agent;
Daphnia tenebrosa metabolite;
human metabolite;
mouse metabolite;
nutraceutical | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| palmitoleic acid | | hexadec-9-enoic acid | algal metabolite;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
human blood serum metabolite | 1980 | 2022 | 18.7 | medium | 1 | 8 | 18 | 18 | 28 | 4 |
| oleic acid | | octadec-9-enoic acid | antioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent | 1947 | 2024 | 24.2 | medium | 57 | 226 | 266 | 258 | 299 | 49 |
| ferulic acid | | ferulic acids | anti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite | 2002 | 2020 | 12.6 | low | 0 | 0 | 0 | 3 | 4 | 0 |
| pectins | | D-galactopyranuronic acid | | 1984 | 2015 | 21.3 | low | 0 | 2 | 0 | 1 | 3 | 0 |
| 1,5-dihydro-fad | | flavin adenine dinucleotide | Escherichia coli metabolite;
mouse metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cocaine | | benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid | adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| eicosapentaenoic acid | | icosapentaenoic acid;
omega-3 fatty acid | anticholesteremic drug;
antidepressant;
antineoplastic agent;
Daphnia galeata metabolite;
fungal metabolite;
micronutrient;
mouse metabolite;
nutraceutical | 1980 | 2023 | 19.9 | low | 34 | 27 | 93 | 66 | 93 | 14 |
| thapsigargin | | butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone | calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor | 2001 | 2013 | 14.8 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| mycophenolic acid | | 2-benzofurans;
gamma-lactone;
monocarboxylic acid;
phenols | anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
environmental contaminant;
immunosuppressive agent;
mycotoxin;
Penicillium metabolite;
xenobiotic | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| clindamycin | | | | 2011 | 2011 | 13.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| gw 6471 | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| lycopene | | acyclic carotene | antioxidant;
plant metabolite | 2006 | 2018 | 11.0 | low | 0 | 0 | 0 | 2 | 4 | 0 |
| fosfomycin | | epoxide;
phosphonic acids | antimicrobial agent;
EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| zithromax | | macrolide antibiotic | antibacterial drug;
environmental contaminant;
xenobiotic | 2017 | 2017 | 7.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| 2-butenal | | enal | | 1999 | 2015 | 18.7 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| y 27632 | | aromatic amide | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| prostaglandin d2 | | prostaglandins D | human metabolite;
mouse metabolite | 2001 | 2002 | 22.2 | low | 0 | 0 | 0 | 5 | 0 | 0 |
| h 89 | | N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| decitabine | | 2'-deoxyribonucleoside | | 2013 | 2014 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| pantethine | | organic disulfide | coenzyme;
nutraceutical | 1989 | 1991 | 34.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| iridoids | | | | 1993 | 2013 | 19.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| dactinomycin | | actinomycin | mutagen | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| gamma-sitosterol | | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols | marine metabolite;
plant metabolite | 1958 | 2019 | 16.7 | low | 0 | 1 | 1 | 6 | 7 | 0 |
| azaserine | | carboxylic ester;
diazo compound;
L-serine derivative;
non-proteinogenic L-alpha-amino acid | antifungal agent;
antimetabolite;
antimicrobial agent;
antineoplastic agent;
glutamine antagonist;
immunosuppressive agent;
metabolite | 1990 | 1994 | 31.3 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| enkephalin, leucine | | pentapeptide;
peptide zwitterion | analgesic;
delta-opioid receptor agonist;
human metabolite;
mu-opioid receptor agonist;
neurotransmitter;
rat metabolite | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| benzyloxycarbonylleucyl-leucyl-leucine aldehyde | | amino aldehyde;
carbamate ester;
tripeptide | proteasome inhibitor | 2006 | 2012 | 15.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| riboflavin | | flavin;
vitamin B2 | anti-inflammatory agent;
antioxidant;
cofactor;
Escherichia coli metabolite;
food colouring;
fundamental metabolite;
human urinary metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite | 1983 | 2015 | 20.3 | low | 0 | 1 | 1 | 2 | 2 | 0 |
| lisofylline | | 1-(5-hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione | anti-inflammatory agent;
immunomodulator | 1997 | 2021 | 12.2 | low | 0 | 0 | 1 | 1 | 1 | 1 |
| sodium bicarbonate | | one-carbon compound;
organic sodium salt | antacid;
food anticaking agent | 1983 | 2005 | 27.3 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| 4,5-epoxy-2-decenal | | enal | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cholestane-3,5,6-triol | | | | 1993 | 1996 | 29.3 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| bromochloroacetic acid | | 2-bromocarboxylic acid;
monocarboxylic acid;
organochlorine compound | | 1989 | 2003 | 27.8 | low | 0 | 1 | 1 | 2 | 0 | 0 |
| 3-carbamoyl-2,2,5,5-tetramethyl-3-pyrroline-1-yloxyl | | | | 2005 | 2006 | 18.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| alpha-asarone | | asarone | anticonvulsant;
GABA modulator | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cinnamaldehyde | | 3-phenylprop-2-enal;
cinnamaldehydes | antifungal agent;
EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor;
flavouring agent;
hypoglycemic agent;
plant metabolite;
sensitiser;
vasodilator agent | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| elaidic acid | | octadec-9-enoic acid | food component | 1980 | 2021 | 17.5 | medium | 3 | 2 | 8 | 6 | 12 | 2 |
| trans-4-coumaric acid | | 4-coumaric acid | food component;
mouse metabolite;
plant metabolite | 1999 | 2015 | 14.7 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| dimethyl fumarate | | diester;
enoate ester;
methyl ester | antipsoriatic;
immunomodulator | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| glycosides | | | | 1993 | 2023 | 19.1 | low | 0 | 0 | 2 | 5 | 1 | 1 |
| sinapinic acid | | sinapic acid | MALDI matrix material;
plant metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| isomethyleugenol | | isomethyleugenol | | 1986 | 2018 | 20.6 | low | 0 | 1 | 7 | 9 | 3 | 0 |
| citral | | enal;
monoterpenoid;
polyprenal | plant metabolite;
volatile oil component | 2004 | 2012 | 16.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| retinol acetate | | acetate ester | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| squalene | | triterpene | human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1953 | 2021 | 24.0 | low | 0 | 4 | 2 | 3 | 6 | 2 |
| stilbenes | | stilbene | | 2001 | 2022 | 12.2 | low | 0 | 0 | 0 | 3 | 5 | 1 |
| phenyl-n-tert-butylnitrone | | | | 1990 | 2008 | 25.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| sorbic acid | | alpha,beta-unsaturated monocarboxylic acid;
sorbic acid | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ricinoleic acid | | (9Z)-12-hydroxyoctadec-9-enoic acid | | 1953 | 2014 | 30.9 | low | 0 | 3 | 2 | 5 | 1 | 0 |
| flavin-adenine dinucleotide | | flavin adenine dinucleotide;
vitamin B2 | cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prosthetic group | 2009 | 2015 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| cannabidiol | | olefinic compound;
phytocannabinoid;
resorcinols | antimicrobial agent;
plant metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| malonyl coenzyme a | | malonyl-CoAs | EC 2.3.1.21 (carnitine O-palmitoyltransferase) inhibitor;
Escherichia coli metabolite;
metabolite;
mouse metabolite | 1982 | 1997 | 35.2 | low | 0 | 3 | 2 | 0 | 0 | 0 |
| arginine vasopressin | | vasopressin | cardiovascular drug;
hematologic agent;
mitogen | 1982 | 2003 | 33.2 | low | 0 | 2 | 1 | 1 | 0 | 0 |
| pyrophosphate | | diphosphate ion | | 1963 | 1999 | 49.0 | low | 0 | 2 | 1 | 0 | 0 | 0 |
| palmitoyl coenzyme a | | 11,12-saturated fatty acyl-CoA;
3-substituted propionyl-CoA;
long-chain fatty acyl-CoA;
palmitoyl bioconjugate | Escherichia coli metabolite;
mouse metabolite | 1986 | 2009 | 27.4 | low | 0 | 1 | 2 | 2 | 0 | 0 |
| gw9662 | | benzamides | | 2004 | 2014 | 16.0 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| amygdalin | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| polidocanol | | hydroxypolyether | hepatotoxic agent;
nonionic surfactant;
sclerotherapy agent | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| sodium metabisulfite | | inorganic sodium salt | food antioxidant | 1990 | 2002 | 28.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| propylthiouracil | | pyrimidinethione | antidote to paracetamol poisoning;
antimetabolite;
antioxidant;
antithyroid drug;
carcinogenic agent;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
hormone antagonist | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| nsc 4347 | | | | 2010 | 2012 | 13.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| arachin | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sesquiterpenes | | | | 2003 | 2014 | 15.6 | low | 0 | 0 | 0 | 5 | 2 | 0 |
| 3,3',4,5'-tetrahydroxystilbene | | catechols;
polyphenol;
resorcinols;
stilbenol | antineoplastic agent;
apoptosis inducer;
geroprotector;
hypoglycemic agent;
plant metabolite;
protein kinase inhibitor;
tyrosine kinase inhibitor | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| caffeic acid | | caffeic acid | geroprotector;
mouse metabolite | 1984 | 2015 | 23.7 | low | 0 | 1 | 2 | 3 | 1 | 0 |
| pongamol | | | | 2015 | 2015 | 9.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| curcumin | | aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol | anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger | 1995 | 2023 | 15.3 | low | 0 | 0 | 4 | 2 | 2 | 3 |
| curcumin | | aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol | anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger | 1995 | 2023 | 14.5 | low | 0 | 0 | 4 | 2 | 3 | 3 |
| nootkatone | | carbobicyclic compound;
enone;
sesquiterpenoid | fragrance;
insect repellent;
plant metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| thiouracil | | nucleobase analogue;
thiocarbonyl compound | antithyroid drug;
metabolite | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| sulindac | | monocarboxylic acid;
organofluorine compound;
sulfoxide | analgesic;
antineoplastic agent;
antipyretic;
apoptosis inducer;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug;
tocolytic agent | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| capsaicin | | capsaicinoid | non-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker | 1999 | 2018 | 19.1 | low | 0 | 0 | 2 | 4 | 1 | 0 |
| oxazolone | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| caryophyllene oxide | | epoxide | metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| chlorogenic acid | | cinnamate ester;
tannin | food component;
plant metabolite | 1984 | 2023 | 16.0 | low | 0 | 1 | 0 | 1 | 0 | 2 |
| thioguanine anhydrous | | 2-aminopurines | anticoronaviral agent;
antimetabolite;
antineoplastic agent | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| thiobarbituric acid | | barbiturates | allergen;
reagent | 1989 | 2014 | 23.4 | low | 0 | 1 | 4 | 2 | 3 | 0 |
| thiourea | | one-carbon compound;
thioureas;
ureas | antioxidant;
chromophore | 1964 | 2016 | 29.7 | low | 0 | 1 | 0 | 1 | 1 | 0 |
| D-fructopyranose | | cyclic hemiketal;
D-fructose;
fructopyranose | sweetening agent | 1997 | 2023 | 12.3 | low | 0 | 0 | 1 | 3 | 1 | 2 |
| thioacetamide | | thiocarboxamide | hepatotoxic agent | 1959 | 1959 | 65.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| digoxin | | cardenolide glycoside;
steroid saponin | anti-arrhythmia drug;
cardiotonic drug;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
epitope | 1987 | 1988 | 36.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| capsazepine | | benzazepine;
catechols;
monochlorobenzenes;
thioureas | capsaicin receptor antagonist | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fumonisin b1 | | diester;
fumonisin;
primary amino compound;
triol | carcinogenic agent;
metabolite | 1999 | 2013 | 15.2 | low | 0 | 0 | 1 | 1 | 2 | 0 |
| sodium taurodeoxycholate | | bile acid taurine conjugate | human metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nadp | | | | 1964 | 2003 | 36.3 | low | 0 | 8 | 9 | 1 | 0 | 0 |
| 1,1-diphenyl-2-picrylhydrazyl | | | | 1995 | 2021 | 14.8 | low | 0 | 0 | 2 | 79 | 48 | 2 |
| t 0070907 | | carbonyl compound;
organohalogen compound | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fusidic acid | | 11alpha-hydroxy steroid;
3alpha-hydroxy steroid;
alpha,beta-unsaturated monocarboxylic acid;
steroid acid;
steroid antibiotic;
sterol ester | EC 2.7.1.33 (pantothenate kinase) inhibitor;
Escherichia coli metabolite;
protein synthesis inhibitor | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| lincomycin | | carbohydrate-containing antibiotic;
L-proline derivative;
monocarboxylic acid amide;
pyrrolidinecarboxamide;
S-glycosyl compound | antimicrobial agent;
bacterial metabolite | 2002 | 2002 | 22.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| valinomycin | | cyclodepsipeptide;
macrocycle | antimicrobial agent;
antiviral agent;
bacterial metabolite;
potassium ionophore | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ranitidine | | C-nitro compound;
furans;
organic sulfide;
tertiary amino compound | anti-ulcer drug;
drug allergen;
environmental contaminant;
H2-receptor antagonist;
xenobiotic | 1986 | 2007 | 27.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| u 0126 | | aryl sulfide;
dinitrile;
enamine;
substituted aniline | antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
osteogenesis regulator;
vasoconstrictor agent | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| laccase | | | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| lithium | | alkali metal atom | | 1984 | 1993 | 36.0 | low | 0 | 2 | 1 | 0 | 0 | 0 |
| cobaltous chloride | | cobalt salt;
inorganic chloride | allergen;
calcium channel blocker;
sensitiser;
two-colour indicator | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nitrogen dioxide | | nitrogen oxide | | 1982 | 2014 | 23.8 | low | 0 | 1 | 1 | 2 | 1 | 0 |
| orlistat | | beta-lactone;
carboxylic ester;
formamides;
L-leucine derivative | anti-obesity agent;
bacterial metabolite;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| loreclezole | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| quinine | | cinchona alkaloid | antimalarial;
muscle relaxant;
non-narcotic analgesic | 2006 | 2009 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| tauro-24,25-dihydrofusidate | | | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 9-diazomethylanthracene | | | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| cystine | | | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| safingol | | amino alcohol | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cytellin | | | | 1958 | 2019 | 15.6 | low | 0 | 1 | 1 | 8 | 9 | 0 |
| salinomycin | | polyketide;
spiroketal | animal growth promotant;
potassium ionophore | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ovalbumin | | | | 1987 | 2017 | 19.4 | low | 1 | 1 | 2 | 3 | 4 | 0 |
| sodium dodecyl sulfate | | organic sodium salt | detergent;
protein denaturant | 1985 | 2012 | 25.9 | low | 0 | 4 | 5 | 6 | 1 | 0 |
| 4-nitrocatechol | | C-nitro compound;
catechols | human xenobiotic metabolite;
lipoxygenase inhibitor | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| crocin | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| mtt formazan | | | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| l 663536 | | aryl sulfide;
indoles;
monocarboxylic acid;
monochlorobenzenes | antineoplastic agent;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
leukotriene antagonist | 1998 | 2008 | 20.2 | low | 0 | 0 | 1 | 3 | 0 | 0 |
| fg 9041 | | quinoxaline derivative | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| alpha-chymotrypsin | | | | 1993 | 2014 | 19.0 | low | 0 | 0 | 1 | 3 | 1 | 0 |
| 17-ketosteroids | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sodium borohydride | | inorganic sodium salt;
metal tetrahydridoborate | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| hydroxyethylcellulose | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| digitoxigenin | | 14beta-hydroxy steroid;
3beta-hydroxy steroid | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-cyclohexyl-3-dodecylurea | | | | 2004 | 2004 | 20.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-mercaptoacetate | | monocarboxylic acid anion | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dimethyl maleate | | diester;
maleate ester;
methyl ester | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| farnesoic acid | | farnesoic acid | animal metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sphingosine | | sphing-4-enine | human metabolite;
mouse metabolite | 1985 | 2023 | 19.6 | low | 0 | 2 | 3 | 1 | 1 | 3 |
| quercetin | | 7-hydroxyflavonol;
pentahydroxyflavone | antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger | 1995 | 2023 | 13.5 | low | 0 | 0 | 1 | 8 | 5 | 3 |
| bilirubin | | biladienes;
dicarboxylic acid | antioxidant;
human metabolite;
mouse metabolite | 1987 | 2016 | 26.8 | low | 1 | 3 | 3 | 1 | 2 | 0 |
| dinoprostone | | prostaglandins E | human metabolite;
mouse metabolite;
oxytocic | 1981 | 2019 | 26.0 | low | 7 | 21 | 31 | 35 | 7 | 0 |
| dinoprost | | monocarboxylic acid;
prostaglandins Falpha | human metabolite;
mouse metabolite | 1984 | 2014 | 25.3 | low | 4 | 6 | 10 | 16 | 2 | 0 |
| leukotriene a4 | | epoxy fatty acid;
leukotriene;
long-chain fatty acid;
oxylipin;
polyunsaturated fatty acid | human metabolite;
mouse metabolite;
plant metabolite | 2009 | 2022 | 8.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| 12-oxophytodienoic acid | | carbocyclic fatty acid;
olefinic fatty acid;
oxo carboxylic acid | | 2008 | 2015 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| apigenin | | trihydroxyflavone | antineoplastic agent;
metabolite | 2022 | 2023 | 1.5 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| calcitriol | | D3 vitamins;
hydroxycalciol;
triol | antineoplastic agent;
antipsoriatic;
bone density conservation agent;
calcium channel agonist;
calcium channel modulator;
hormone;
human metabolite;
immunomodulator;
metabolite;
mouse metabolite;
nutraceutical | 1983 | 2022 | 25.8 | low | 0 | 1 | 2 | 0 | 0 | 1 |
| calcitriol | | D3 vitamins;
hydroxycalciol;
triol | antineoplastic agent;
antipsoriatic;
bone density conservation agent;
calcium channel agonist;
calcium channel modulator;
hormone;
human metabolite;
immunomodulator;
metabolite;
mouse metabolite;
nutraceutical | 1983 | 1996 | 33.7 | low | 0 | 1 | 2 | 0 | 0 | 0 |
| vitamin k semiquinone radical | | | | 1951 | 2018 | 40.8 | low | 0 | 3 | 1 | 0 | 1 | 0 |
| beta carotene | | carotenoid beta-end derivative;
cyclic carotene | antioxidant;
biological pigment;
cofactor;
ferroptosis inhibitor;
human metabolite;
mouse metabolite;
plant metabolite;
provitamin A | 1987 | 2023 | 14.9 | low | 2 | 1 | 10 | 56 | 49 | 7 |
| leukotriene b4 | | dihydroxy monocarboxylic acid;
hydroxy polyunsaturated fatty acid;
leukotriene;
long-chain fatty acid | human metabolite;
mouse metabolite;
plant metabolite;
vasoconstrictor agent | 1985 | 2014 | 30.0 | low | 3 | 9 | 14 | 7 | 1 | 0 |
| leukotriene c4 | | leukotriene | bronchoconstrictor agent;
human metabolite;
mouse metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| thromboxane a2 | | epoxy monocarboxylic acid;
thromboxanes A | mouse metabolite | 1982 | 2003 | 31.2 | low | 1 | 2 | 6 | 1 | 0 | 0 |
| retinol palmitate | | all-trans-retinyl ester;
retinyl palmitate | antioxidant;
Escherichia coli metabolite;
human xenobiotic metabolite | 1999 | 2017 | 18.5 | low | 0 | 0 | 2 | 1 | 1 | 0 |
| coniferaldehyde | | cinnamaldehydes;
guaiacols;
phenylpropanoid | antifungal agent;
plant metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 8,11,14-eicosatrienoic acid | | fatty acid 20:3;
long-chain fatty acid | fungal metabolite;
human metabolite;
nutraceutical | 1980 | 2021 | 24.9 | low | 4 | 27 | 25 | 10 | 22 | 3 |
| vitamin k1 hydroquinone | | naphthohydroquinone;
polyprenylhydroquinone | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| rumenic acid | | octadeca-9,11-dienoic acid | | 2005 | 2018 | 16.1 | low | 1 | 0 | 0 | 7 | 2 | 0 |
| furylfuramide | | acrylamides;
C-nitro compound;
nitrofuran antibiotic;
primary carboxamide | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 15-keto-13,14-dihydroprostaglandin e2 | | prostaglandins E | | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 15-ketoprostaglandin e2 | | prostaglandins E | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| alprostadil | | prostaglandins E | anticoagulant;
human metabolite;
platelet aggregation inhibitor;
vasodilator agent | 1984 | 2005 | 32.9 | low | 2 | 8 | 4 | 2 | 0 | 0 |
| 5-hydroxy-6,8,11,14-eicosatetraenoic acid | | HETE | human metabolite;
mouse metabolite | 1985 | 2013 | 26.8 | low | 0 | 2 | 4 | 2 | 1 | 0 |
| vitamin d 2 | | hydroxy seco-steroid;
seco-ergostane;
vitamin D | bone density conservation agent;
nutraceutical;
plant metabolite;
rodenticide | 1963 | 1964 | 60.8 | low | 0 | 5 | 0 | 0 | 0 | 0 |
| stigmasterol | | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols;
stigmastane sterol | plant metabolite | 2002 | 2020 | 11.0 | low | 0 | 0 | 0 | 2 | 5 | 0 |
| cholecalciferol | | D3 vitamins;
hydroxy seco-steroid;
seco-cholestane;
secondary alcohol;
steroid hormone | geroprotector;
human metabolite | 1963 | 2012 | 30.0 | low | 1 | 1 | 0 | 1 | 1 | 0 |
| rutin | | disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone | antioxidant;
metabolite | 1991 | 2022 | 17.7 | low | 0 | 0 | 1 | 1 | 0 | 1 |
| kaempferol | | 7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone | antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite | 2014 | 2018 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| prostaglandin a2 | | prostaglandins A | human metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 9-deoxy-delta-9-prostaglandin d2 | | prostaglandins J | human metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 15-ketoprostaglandin f2alpha | | prostaglandins Falpha | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 6-ketoprostaglandin f1 alpha | | prostaglandins Falpha | human metabolite;
mouse metabolite | 1982 | 2008 | 31.2 | low | 3 | 8 | 8 | 5 | 0 | 0 |
| 11-dehydro-thromboxane b2 | | thromboxane | human metabolite | 1996 | 1999 | 26.5 | low | 1 | 0 | 2 | 0 | 0 | 0 |
| arachidonic acid omega-9 hydroperoxide | | HPETE | mouse metabolite | 1991 | 2009 | 24.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| zeaxanthin | | carotenol | antioxidant;
bacterial metabolite;
cofactor | 2006 | 2008 | 17.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| lipoxin a4 | | hydroxy polyunsaturated fatty acid;
lipoxin;
long-chain fatty acid | human metabolite;
metabolite | 2013 | 2017 | 9.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| gamma-linolenic acid | | linolenic acid;
omega-6 fatty acid | human metabolite;
mouse metabolite;
plant metabolite | 1965 | 2023 | 25.9 | medium | 15 | 32 | 47 | 23 | 19 | 4 |
| alpha-linolenic acid | | linolenic acid;
omega-3 fatty acid | micronutrient;
mouse metabolite;
nutraceutical | 1945 | 2023 | 19.9 | high | 63 | 97 | 203 | 228 | 266 | 38 |
| prostaglandin f1 | | prostaglandins Falpha | human metabolite | 1987 | 2013 | 24.0 | low | 1 | 1 | 0 | 0 | 1 | 0 |
| genistein | | 7-hydroxyisoflavones | antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor | 2001 | 2018 | 15.8 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| amphotericin b | | antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic | antiamoebic agent;
antiprotozoal drug;
bacterial metabolite | 1963 | 2012 | 44.2 | low | 0 | 3 | 1 | 0 | 1 | 0 |
| pulmicort | | 11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
cyclic acetal;
glucocorticoid;
primary alpha-hydroxy ketone | anti-inflammatory drug;
bronchodilator agent;
drug allergen | 1995 | 2023 | 15.0 | low | 1 | 0 | 1 | 0 | 0 | 1 |
| erucic acid | | docosenoic acid | | 1986 | 2020 | 22.2 | low | 0 | 1 | 2 | 2 | 1 | 0 |
| nervonic acid | | tetracosenoic acid | | 1997 | 2016 | 18.3 | medium | 0 | 0 | 4 | 3 | 3 | 0 |
| petroselinic acid | | octadec-6-enoic acid | plant metabolite | 1993 | 1998 | 28.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| cyclobenzaprine | | 9,11,13-octadecatrienoic acid | antineoplastic agent;
plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 11-octadecenoic acid | | vaccenic acid | | 1998 | 2021 | 15.8 | medium | 2 | 0 | 1 | 21 | 11 | 1 |
| jasmonic acid | | oxo monocarboxylic acid | jasmonates;
plant metabolite | 2002 | 2023 | 11.9 | low | 0 | 0 | 0 | 7 | 6 | 2 |
| 2-hexenal, z-isomer | | 2-hexenal | antibacterial agent;
flavouring agent;
plant metabolite | 2002 | 2020 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| astaxanthine | | carotenol;
carotenone | animal metabolite;
anticoagulant;
antioxidant;
food colouring;
plant metabolite | 2013 | 2020 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| lutein | | carotenol | food colouring;
plant metabolite | 1993 | 2018 | 19.3 | low | 0 | 0 | 2 | 3 | 1 | 0 |
| torularhodin | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| torulene | | carotene;
polyene | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cucurbitacin b | | cucurbitacin;
secondary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nsc 106399 | | cucurbitacin;
tertiary alpha-hydroxy ketone | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| brassicasterol | | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols | algal metabolite;
animal metabolite;
biomarker;
EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor;
human metabolite;
marine metabolite;
plant metabolite;
sterol biosynthesis inhibitor | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| geranylgeraniol | | geranylgeraniol | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| esculetin | | hydroxycoumarin | antioxidant;
plant metabolite;
ultraviolet filter | 1984 | 1996 | 35.0 | low | 0 | 2 | 2 | 0 | 0 | 0 |
| humulene | | alpha-humulene | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| humulene | | alpha-humulene | | 2010 | 2015 | 11.8 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| oleuropein | | beta-D-glucoside;
catechols;
diester;
methyl ester;
pyrans;
secoiridoid glycoside | anti-inflammatory agent;
antihypertensive agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
NF-kappaB inhibitor;
nutraceutical;
plant metabolite;
radical scavenger | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-methylquercetin | | 7-hydroxyflavonol;
monomethoxyflavone;
tetrahydroxyflavone | anticoagulant;
EC 1.14.18.1 (tyrosinase) inhibitor;
metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| morin | | 7-hydroxyflavonol;
pentahydroxyflavone | angiogenesis modulating agent;
anti-inflammatory agent;
antibacterial agent;
antihypertensive agent;
antineoplastic agent;
antioxidant;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
hepatoprotective agent;
metabolite;
neuroprotective agent | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pterostilbene | | diether;
methoxybenzenes;
stilbenol | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
hypoglycemic agent;
neuroprotective agent;
neurotransmitter;
plant metabolite;
radical scavenger | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| caffeic acid phenethyl ester | | alkyl caffeate ester | anti-inflammatory agent;
antibacterial agent;
antineoplastic agent;
antioxidant;
antiviral agent;
immunomodulator;
metabolite;
neuroprotective agent | 1993 | 2011 | 22.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| rosmarinic acid | | rosmarinic acid | geroprotector;
plant metabolite | 2008 | 2015 | 13.0 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| acteoside | | catechols;
cinnamate ester;
disaccharide derivative;
glycoside;
polyphenol | anti-inflammatory agent;
antibacterial agent;
antileishmanial agent;
neuroprotective agent;
plant metabolite | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ellagic acid | | catechols;
cyclic ketone;
lactone;
organic heterotetracyclic compound;
polyphenol | antioxidant;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor;
EC 2.4.1.1 (glycogen phosphorylase) inhibitor;
EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor;
EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor;
EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
food additive;
fungal metabolite;
geroprotector;
plant metabolite;
skin lightening agent | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| soraphen a | | cyclic hemiketal;
ether;
macrolide;
olefinic compound | bacterial metabolite;
EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor;
teratogenic agent | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| coenzyme q10 | | ubiquinones | antioxidant;
ferroptosis inhibitor;
human metabolite | 2000 | 2012 | 18.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| anandamide | | endocannabinoid;
N-acylethanolamine 20:4 | human blood serum metabolite;
neurotransmitter;
vasodilator agent | 2012 | 2023 | 8.2 | low | 0 | 0 | 0 | 0 | 4 | 1 |
| cerulenin | | epoxide;
monocarboxylic acid amide | antifungal agent;
antiinfective agent;
antilipemic drug;
antimetabolite;
antimicrobial agent;
fatty acid synthesis inhibitor | 1983 | 2002 | 31.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| ethyl linoleate | | long-chain fatty acid ethyl ester | anti-inflammatory agent;
plant metabolite | 1959 | 1999 | 44.8 | low | 0 | 2 | 2 | 0 | 0 | 0 |
| 8-epi-prostaglandin f2alpha | | F2-isoprostane | biomarker;
bronchoconstrictor agent;
vasoconstrictor agent | 1998 | 2014 | 19.4 | low | 0 | 0 | 1 | 3 | 1 | 0 |
| glyceryl 2-arachidonate | | 2-acylglycerol 20:4;
endocannabinoid | human metabolite | 2009 | 2014 | 12.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| tocotrienol, alpha | | tocotrienol;
vitamin E | ferroptosis inhibitor;
human metabolite;
neuroprotective agent;
plant metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-hydroxyestradiol | | 4-hydroxy steroid | metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| isotretinoin | | retinoic acid | antineoplastic agent;
keratolytic drug;
teratogenic agent | 1987 | 1997 | 32.0 | low | 1 | 1 | 1 | 0 | 0 | 0 |
| 2-decenoic acid | | 2-decenoic acid | human metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| cis-vaccenic acid | | vaccenic acid | | 1982 | 2003 | 35.0 | low | 0 | 3 | 0 | 1 | 0 | 0 |
| 12-octadecenoic acid | | long-chain fatty acid | | 1987 | 2022 | 17.7 | high | 0 | 1 | 0 | 1 | 0 | 1 |
| 9,11-linoleic acid | | octadeca-9,11-dienoic acid | anti-inflammatory agent;
antiatherogenic agent;
antineoplastic agent;
apoptosis inducer;
bacterial xenobiotic metabolite;
human metabolite | 1987 | 2021 | 19.7 | low | 2 | 2 | 4 | 6 | 6 | 1 |
| trans-10,cis-12-conjugated linoleic acid | | octadeca-10,12-dienoic acid | | 2005 | 2018 | 16.2 | low | 1 | 0 | 0 | 8 | 1 | 0 |
| 10,12-octadecadienoic acid | | lipid | | 2002 | 2011 | 17.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 9-hydroperoxy-11,12-octadecadienoic acid | | hydroperoxy polyunsaturated fatty acid;
octadecadienoic acid | | 1986 | 2006 | 27.5 | high | 0 | 2 | 8 | 4 | 0 | 0 |
| 9-hydroxy-10,12-octadecadienoic acid | | HODE;
octadecadienoic acid | human metabolite;
metabolite;
mouse metabolite;
plant metabolite | 1982 | 2020 | 24.5 | high | 1 | 3 | 17 | 3 | 7 | 0 |
| 13-hydroxy-9,11-octadecadienoic acid | | octadecadienoic acid | | 1982 | 2021 | 25.3 | high | 2 | 10 | 55 | 16 | 12 | 1 |
| 9,10-dihydroxy-12-octadecenoic acid | | long-chain fatty acid | | 1999 | 2020 | 16.7 | high | 0 | 0 | 1 | 1 | 1 | 0 |
| 9,10,13-trihydroxy-11-octadecenoic acid | | long-chain fatty acid;
monounsaturated fatty acid;
straight-chain fatty acid;
TriHOME | human blood serum metabolite | 2020 | 2020 | 4.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| 9,12,13-trihydroxy-10-octadecenoic acid | | | | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| 9-oxo-10,12-octadecadienoic acid | | enone;
oxooctadecadienoic acid | metabolite | 1998 | 2014 | 18.0 | medium | 0 | 0 | 1 | 0 | 1 | 0 |
| 13-oxo-9,11-octadecadienoic acid | | 13-oxo-9,11-octadecadienoic acid;
oxo fatty acid | metabolite | 1991 | 2007 | 23.7 | high | 0 | 0 | 3 | 3 | 0 | 0 |
| 12,13-epoxy-9-octadecenoic acid | | long-chain fatty acid | | 2000 | 2002 | 22.6 | high | 0 | 0 | 1 | 4 | 0 | 0 |
| 9,10-epoxy-12-octadecenoate | | medium-chain fatty acid | | 1988 | 2002 | 26.8 | medium | 0 | 1 | 3 | 1 | 0 | 0 |
| 15-keto-13,14-dihydroprostaglandin f2alpha | | ketone;
prostaglandins Falpha | metabolite | 2002 | 2007 | 20.0 | low | 1 | 0 | 0 | 4 | 0 | 0 |
| prostaglandin i3 | | prostanoid | | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 2,3-dinor-6-ketoprostaglandin f1alpha | | 4-oxo monocarboxylic acid;
prostanoid;
secondary alcohol | metabolite | 1989 | 1991 | 34.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| thromboxane b2 | | thromboxanes B | human metabolite;
mouse metabolite | 1981 | 2013 | 31.2 | low | 7 | 15 | 23 | 5 | 1 | 0 |
| 2,3-dinor-thromboxane b2 | | thromboxane | | 1991 | 1998 | 30.0 | low | 1 | 0 | 3 | 0 | 0 | 0 |
| 14,15-dihydroxyeicosatrienoic acid | | DHET;
diol;
secondary allylic alcohol | mouse metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 20-hydroxy-5,8,11,14-eicosatetraenoic acid | | HETE;
hydroxy monocarboxylic acid | human metabolite;
mouse metabolite | 2001 | 2003 | 22.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| arachidonic acid 5-hydroperoxide | | HPETE | human xenobiotic metabolite | 1991 | 2001 | 27.2 | low | 0 | 0 | 4 | 1 | 0 | 0 |
| 2-heptenal | | enal;
medium-chain fatty aldehyde;
monounsaturated fatty aldehyde | plant metabolite;
uremic toxin | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2-nonenal, (trans)-isomer | | enal;
medium-chain fatty aldehyde;
monounsaturated fatty aldehyde | plant metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-nonenal | | fatty aldehyde | | 2001 | 2001 | 23.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-hydroxy-2-nonenal | | 4-hydroxynon-2-enal;
4-hydroxynonenal | | 1988 | 2019 | 22.7 | low | 0 | 1 | 6 | 6 | 2 | 0 |
| (2e)-decenal | | 2-decenal | alarm pheromone;
mutagen;
nematicide | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,4-decadienal | | polyunsaturated fatty aldehyde | apoptosis inducer;
nematicide | 2001 | 2008 | 18.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| linoleoyl ethanolamide | | N-acylethanolamine 18:2 | EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-monooleoyl-rac-glycerol | | 1-acylglycerol 18:1;
monooleoylglycerol | plant metabolite | 2002 | 2004 | 21.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| monolinolein | | 1-acylglycerol 18:2;
rac-1-monoacylglycerol | antiviral agent;
human metabolite;
plant metabolite | 2011 | 2015 | 10.7 | medium | 0 | 0 | 0 | 0 | 3 | 0 |
| sphingosine 1-phosphate | | sphingoid 1-phosphate | mouse metabolite;
signalling molecule;
sphingosine-1-phosphate receptor agonist;
T-cell proliferation inhibitor;
vasodilator agent | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cholesteryl oleate | | CE(18:1);
cholesteryl octadec-9-enoate | mouse metabolite | 2004 | 2015 | 15.7 | low | 1 | 0 | 0 | 2 | 1 | 0 |
| methyl linoleate | | fatty acid methyl ester | plant metabolite | 1963 | 2020 | 31.3 | low | 1 | 6 | 3 | 8 | 1 | 0 |
| phenylephrine hydrochloride | | hydrochloride | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| naloxone | | morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol | antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| vitamin k 1 | | phylloquinones;
vitamin K | cofactor;
human metabolite;
plant metabolite | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| sirolimus | | antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol | antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| gamma-cyclodextrin | | cyclodextrin | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cerium | | CE(18:2);
cholesteryl octadeca-9,12-dienoate | human metabolite;
mouse metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fenretinide | | monocarboxylic acid amide;
retinoid | antineoplastic agent;
antioxidant | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| morphine | | morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound | anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| morphine | | morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound | anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic | 1999 | 2004 | 22.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| deamino arginine vasopressin | | heterodetic cyclic peptide | diagnostic agent;
renal agent;
vasopressin receptor agonist | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 15-deoxy-delta(12,14)-prostaglandin j2 | | prostaglandins J | electrophilic reagent;
insulin-sensitizing drug;
metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| enprostil | | | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| lysophosphatidic acid | | 1-acyl-sn-glycerol 3-phosphate | | 2004 | 2013 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| lysophosphatidylcholines | | 1-O-acyl-sn-glycero-3-phosphocholine | | 1963 | 2022 | 27.5 | low | 0 | 4 | 6 | 4 | 4 | 1 |
| cytochalasin b | | cytochalasin;
lactam;
lactone;
organic heterotricyclic compound | actin polymerisation inhibitor;
metabolite;
mycotoxin;
platelet aggregation inhibitor | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| sq 29548 | | | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| su 6656 | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| delta(3)-hexadecenoic acid | | hexadecenoic acid | plant metabolite | 1964 | 1964 | 60.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| octadecadienoic acid | | | | 1964 | 2015 | 25.2 | high | 1 | 5 | 4 | 6 | 5 | 0 |
| 5,9,12-octadecatrienoic acid | | octadecatrienoic acid | | 1984 | 1986 | 39.0 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| stearidonic acid | | long-chain fatty acid;
octadecatetraenoic acid;
omega-3 fatty acid | Daphnia galeata metabolite;
mouse metabolite;
plant metabolite | 2019 | 2021 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| 11,14,17-eicosatrienoate | | fatty acid 20:3;
omega-3 fatty acid | | 1982 | 1990 | 38.0 | medium | 0 | 1 | 1 | 0 | 0 | 0 |
| mead acid | | 5,8,11-eicosatrienoic acid | | 1985 | 2019 | 21.4 | medium | 1 | 3 | 2 | 0 | 4 | 0 |
| juniperonic acid | | icosatetraenoic acid | plant metabolite | 2007 | 2015 | 13.0 | high | 0 | 0 | 0 | 1 | 1 | 0 |
| ximenynic acid | | long-chain fatty acid | | 1987 | 2020 | 20.5 | high | 0 | 1 | 0 | 0 | 1 | 0 |
| 12-hydroxy-5,8,10-heptadecatrienoic acid | | hydroxy polyunsaturated fatty acid;
long-chain fatty acid;
trienoic fatty acid | metabolite | 1992 | 2018 | 22.3 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| lesquerolic acid | | | | 1998 | 2003 | 23.5 | high | 0 | 0 | 1 | 1 | 0 | 0 |
| 1,2-oleoylphosphatidylcholine | | phosphatidylcholine(1+) | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| biliverdine | | | | 1987 | 1990 | 36.0 | low | 0 | 2 | 1 | 0 | 0 | 0 |
| bisdemethoxycurcumin | | beta-diketone;
diarylheptanoid;
enone;
polyphenol | EC 3.2.1.1 (alpha-amylase) inhibitor;
metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| centaureidin | | trihydroxyflavone;
trimethoxyflavone | antineoplastic agent;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
plant metabolite | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| beta-farnesene | | beta-farnesene | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| andrographolide | | carbobicyclic compound;
gamma-lactone;
labdane diterpenoid;
primary alcohol;
secondary alcohol | anti-HIV agent;
anti-inflammatory drug;
antineoplastic agent;
metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| icaritin | | | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| icariin | | flavonols;
glycosyloxyflavone | antioxidant;
bone density conservation agent;
EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor;
phytoestrogen | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ligustilide | | butenolide | metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methyl linolenate | | fatty acid methyl ester | insect attractant;
plant metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| osthenol | | hydroxycoumarin | antifungal agent;
plant metabolite | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| trilinolein | | 1,2-diacyl-3-linoleoylglycerol;
1,3-diacyl-2-linoleoylglycerol;
linoleoyl containing 1,2,3-triacyl-sn-glycerol;
TG(18:2/18:2/18:2);
triglyceride | mouse metabolite | 1958 | 2019 | 26.0 | medium | 0 | 2 | 2 | 4 | 2 | 0 |
| caryophyllene | | | | 2006 | 2011 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| ergosterol-5,8-peroxide | | 3beta-sterol;
ergostanoid;
organic peroxide;
phytosterols | antimycobacterial drug;
antineoplastic agent;
metabolite;
trypanocidal drug | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| lead | | carbon group element atom;
elemental lead;
metal atom | neurotoxin | 1995 | 2012 | 20.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| butylidenephthalide | | isobenzofuranone | | 2005 | 2016 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 12-hydroxy-5,8,10,14-eicosatetraenoic acid | | | | 1987 | 2013 | 29.4 | low | 0 | 5 | 13 | 1 | 1 | 0 |
| 13-hydroperoxy-9,11-octadecadienoic acid | | hydroperoxy polyunsaturated fatty acid;
octadecadienoic acid | | 1984 | 2016 | 25.8 | high | 0 | 5 | 20 | 9 | 2 | 0 |
| 15-hydroxy-5,8,11,13-eicosatetraenoic acid | | | | 1982 | 2007 | 30.4 | low | 1 | 7 | 11 | 3 | 0 | 0 |
| diamide | | 1,1'-azobis(N,N-dimethylformamide) | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid | | | | 1995 | 2013 | 20.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| antimony | | metalloid atom;
pnictogen | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cesium | | alkali metal atom | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| triphenyltin | | | | 2011 | 2017 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| rubidium | | alkali metal atom | | 1992 | 1997 | 29.5 | low | 1 | 0 | 2 | 0 | 0 | 0 |
| aluminum | | boron group element atom;
elemental aluminium;
metal atom | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| strontium | | alkaline earth metal atom | | 1994 | 2011 | 22.7 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| triethyltin | | | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| arsenic | | metalloid atom;
pnictogen | micronutrient | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sulfur | | chalcogen;
nonmetal atom | macronutrient | 1996 | 2020 | 16.0 | low | 0 | 0 | 1 | 2 | 2 | 0 |
| ethyl oleate | | long-chain fatty acid ethyl ester | acaricide;
plant metabolite | 2004 | 2009 | 17.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| methyl oleate | | fatty acid methyl ester | | 1945 | 2017 | 41.7 | low | 0 | 2 | 0 | 0 | 1 | 0 |
| linoleyl alcohol | | fatty alcohol 18:2;
long-chain primary fatty alcohol | | 1998 | 2009 | 20.5 | high | 0 | 0 | 1 | 1 | 0 | 0 |
| methoprene | | isopropyl 11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate;
isopropyl ester | juvenile hormone mimic | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ethyl arachidonate | | long-chain fatty acid ethyl ester | human blood serum metabolite;
human xenobiotic metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| germacrene d | | | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| diphenylhexatriene | | alkatriene | fluorochrome | 1989 | 2000 | 31.3 | low | 0 | 2 | 5 | 0 | 0 | 0 |
| eleostearic acid | | octadecatrienoic acid | | 2006 | 2018 | 12.6 | low | 0 | 0 | 0 | 3 | 2 | 0 |
| ajoene | | sulfoxide | | 2005 | 2018 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| dimyristoylphosphatidylcholine | | 1,2-diacyl-sn-glycero-3-phosphocholine;
phosphatidylcholine 28:0;
tetradecanoate ester | antigen;
mouse metabolite | 1995 | 2016 | 18.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| ecdysterone | | 14alpha-hydroxy steroid;
20-hydroxy steroid;
22-hydroxy steroid;
25-hydroxy steroid;
2beta-hydroxy steroid;
3beta-sterol;
ecdysteroid;
phytoecdysteroid | animal metabolite;
plant metabolite | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| deoxyribose | | deoxypentose | human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1991 | 2005 | 23.8 | low | 0 | 0 | 2 | 6 | 0 | 0 |
| fumarates | | butenedioate;
C4-dicarboxylate | human metabolite;
metabolite;
Saccharomyces cerevisiae metabolite | 1963 | 2015 | 28.0 | low | 1 | 1 | 1 | 1 | 1 | 0 |
| cysteine | | cysteinium | fundamental metabolite | 2007 | 2022 | 10.3 | low | 0 | 0 | 0 | 2 | 4 | 1 |
| thyronines | | thyronine | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| silicon | | carbon group element atom;
metalloid atom;
nonmetal atom | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| crepenynic acid | | long-chain fatty acid anion;
straight-chain fatty acid anion;
unsaturated fatty acid anion | | 1985 | 2020 | 20.2 | high | 0 | 2 | 2 | 2 | 3 | 0 |
| phosphorus | | monoatomic phosphorus;
nonmetal atom;
pnictogen | macronutrient | 1965 | 2018 | 31.0 | low | 0 | 3 | 5 | 1 | 1 | 0 |
| 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | | | | 2004 | 2023 | 11.7 | low | 0 | 0 | 0 | 4 | 9 | 1 |
| lavandulol | | lavandulol | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| demethoxycurcumin | | beta-diketone;
diarylheptanoid;
enone;
polyphenol | anti-inflammatory agent;
antineoplastic agent;
metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| panaxynol | | long-chain fatty alcohol | | 1981 | 2018 | 24.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| bergamottin | | furanocoumarin | metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sulindac sulfone | | monocarboxylic acid;
organofluorine compound;
sulfone | apoptosis inducer;
cyclooxygenase 2 inhibitor;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| cgp 52608 | | thiazolidinone | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| oleoyl-coenzyme a | | octadecenoyl-CoA | Escherichia coli metabolite;
mouse metabolite | 1984 | 2002 | 31.0 | low | 0 | 1 | 3 | 1 | 0 | 0 |
| triolein | | triglyceride | Caenorhabditis elegans metabolite;
plant metabolite | 1964 | 2021 | 26.1 | low | 0 | 3 | 3 | 3 | 4 | 1 |
| docosapentaenoic acid | | docosapentaenoic acid;
omega-3 fatty acid | algal metabolite;
human metabolite | 1977 | 2023 | 18.6 | low | 3 | 2 | 8 | 10 | 11 | 1 |
| resiniferatoxin | | carboxylic ester;
diterpenoid;
enone;
monomethoxybenzene;
organic heteropentacyclic compound;
ortho ester;
phenols;
tertiary alpha-hydroxy ketone | analgesic;
neurotoxin;
plant metabolite;
TRPV1 agonist | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| abscisic acid | | 2-trans-abscisic acid | | 2010 | 2022 | 7.8 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2h-pyran-2-one | | naphthalenes | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| su 1498 | | enamide;
monocarboxylic acid amide;
nitrile;
phenols;
secondary carboxamide | vascular endothelial growth factor receptor antagonist | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| selenium | | chalcogen;
nonmetal atom | micronutrient | 1981 | 2019 | 24.1 | low | 1 | 4 | 10 | 5 | 6 | 0 |
| tellurium | | chalcogen;
metalloid atom | | 2007 | 2013 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| oxalates | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| clinoptilolite | | | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ethyl linolenate | | | | 1987 | 2015 | 23.0 | medium | 0 | 1 | 0 | 0 | 1 | 0 |
| 4,7,10,13,16,19-docosahexaenoic acid ethyl ester | | | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| dizocilpine maleate | | maleate salt;
tetracyclic antidepressant | anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| antimycin a | | amidobenzoic acid | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cholestanol | | cholestanoid | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bongkrekic acid | | ether;
olefinic compound;
tricarboxylic acid | apoptosis inhibitor;
ATP/ADP translocase inhibitor;
bacterial metabolite;
EC 2.5.1.18 (glutathione transferase) inhibitor;
toxin | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-palmitoyl-2-oleoylphosphatidylcholine | | | | 1995 | 2016 | 18.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| falcarindiol | | organic molecular entity | metabolite | 1998 | 2018 | 17.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| dehydroergosterol | | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols | biomarker;
metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-oleoyl-2-acetylglycerol | | 1,2-diglyceride | | 1988 | 1990 | 35.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| involucrin | | | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid | | HPETE | human xenobiotic metabolite | 1987 | 2009 | 29.0 | low | 0 | 4 | 3 | 2 | 0 | 0 |
| linoleylanilide | | anilide;
fatty amide | | 1993 | 1997 | 29.0 | medium | 0 | 0 | 3 | 0 | 0 | 0 |
| 1,2-dioleoyloxy-3-(trimethylammonium)propane | | | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| diarachidonyl diglyceride | | | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| concanamycin a | | carbamate ester;
concanamycin | antifungal agent;
EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor;
metabolite | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| bwa 4c | | | | 1988 | 1996 | 31.3 | low | 0 | 1 | 2 | 0 | 0 | 0 |
| ono 4057 | | | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1-palmitoyl-2-linoleoylphosphatidylcholine | | | | 1995 | 2014 | 23.5 | low | 0 | 0 | 3 | 0 | 1 | 0 |
| 7-oxoprostaglandin i2 | | | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| thermozymocidin | | alpha-amino fatty acid;
hydroxy monocarboxylic acid;
non-proteinogenic alpha-amino acid;
sphingoid | antifungal agent;
antimicrobial agent;
antineoplastic agent;
apoptosis inducer;
EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor;
fungal metabolite;
immunosuppressive agent | 2004 | 2010 | 17.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| 11-hydroxy-9,12-octadecadienoic acid | | HODE;
secondary allylic alcohol | | 1993 | 2000 | 27.0 | high | 0 | 0 | 4 | 0 | 0 | 0 |
| 3-hydroxy-5,8,11,14-eicosatetraenoic acid | | | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 8-hydroperoxylinoleic acid | | HPODE;
octadecanoid | | 1996 | 2009 | 21.5 | high | 0 | 0 | 1 | 1 | 0 | 0 |
| 8-hydroxylinoleic acid | | | | 2000 | 2017 | 15.5 | high | 0 | 0 | 1 | 0 | 1 | 0 |
| methyl 6,7-10,11-bis(epoxy)-3,7,11-trimethyl-2-dodecenoate | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid | | hydroxydocosahexaenoic acid;
secondary allylic alcohol | human xenobiotic metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 19-hydroxy-5,8,11,14-eicosatetraenoic acid | | | | 2000 | 2017 | 15.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| tetracosahexaenoic acid | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 14-hydroxydocosahexaenoate | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| eicosa-5,11,14-trienoic acid | | | | 2007 | 2015 | 12.8 | medium | 0 | 0 | 0 | 1 | 3 | 0 |
| 13-hydroperoxy-9,11,15-octadecatrienoic acid | | | | 1995 | 2000 | 26.5 | medium | 0 | 0 | 2 | 0 | 0 | 0 |
| valerenic acid | | carbobicyclic compound;
monocarboxylic acid;
sesquiterpenoid | GABA modulator;
plant metabolite;
sedative;
volatile oil component | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1,2-linoleoylphosphatidylcholine | | | | 1994 | 2001 | 26.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| linoleoyl-coenzyme a | | | | 1984 | 2011 | 31.8 | medium | 0 | 3 | 0 | 0 | 1 | 0 |
| colneleic acid | | divinyl ether fatty acid;
long-chain fatty acid;
straight-chain fatty acid | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-oxo-2-nonenal | | enal;
enone | human metabolite | 2003 | 2019 | 16.0 | low | 0 | 0 | 0 | 5 | 1 | 0 |
| vernoleate | | oxylipin;
vernolic acid | | 1993 | 2012 | 23.9 | high | 0 | 0 | 4 | 2 | 1 | 0 |
| 18-hydroxy-5,8,11,14-eicosatetraenoic acid | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| linoleic acid hydroxamate | | hydroxamic acid | | 1994 | 1994 | 30.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| 16-(2'-o-glucopyranosylglucopyranosyloxy)hexadecanoic acid 1',4''-lactone 6',6''-diacetate | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| beta-escin | | | | 1960 | 2019 | 37.3 | low | 0 | 4 | 0 | 1 | 2 | 0 |
| androst-16-en-3-one | | 3-oxo steroid;
androstanoid | mammalian metabolite;
pheromone | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| beta-tocopherol | | tocopherol;
vitamin E | food component;
plant metabolite | 2009 | 2016 | 12.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| gadolinium dtpa | | gadolinium coordination entity | MRI contrast agent | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sq-23377 | | cyclic ether;
enol;
polyunsaturated fatty acid;
very long-chain fatty acid | calcium ionophore;
metabolite | 1989 | 1990 | 34.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| enkephalin, leucine-2-alanine | | | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| oleoyl-estrone | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pinostrobin | | ether;
flavonoids | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 3-tyrosine | | hydroxyphenylalanine;
L-alpha-amino acid zwitterion;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
phenols | plant metabolite | 2000 | 2000 | 24.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| staurosporine | | ammonium ion derivative | | 1988 | 1996 | 32.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| cyclo(leucyl-prolyl) | | dipeptide;
homodetic cyclic peptide;
pyrrolopyrazine | bacterial metabolite;
marine metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hypericum | | penicillanic acids | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 10-hydroxystearic acid | | hydroxy fatty acid;
long-chain fatty acid | bacterial xenobiotic metabolite | 1993 | 2006 | 25.7 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| formazans | | | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| triacsin c | | hydrazone;
nitroso compound;
olefinic compound | antimalarial;
apoptosis inhibitor;
bacterial metabolite;
EC 3.1.1.64 (retinoid isomerohydrolase) inhibitor;
EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
vasodilator agent | 2005 | 2013 | 15.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| 2-hydroxy-9-cis-octadecenoic acid | | 2-hydroxy fatty acid;
hydroxy monounsaturated fatty acid;
long-chain fatty acid | antihypertensive agent;
antineoplastic agent;
apoptosis inducer | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bo 653 | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| euk-134 | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sincalide | | oligopeptide | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| sincalide | | oligopeptide | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| capsiate | | carboxylic ester;
monomethoxybenzene;
phenols | angiogenesis inhibitor;
anti-allergic agent;
anti-inflammatory agent;
antioxidant;
capsaicin receptor agonist;
hypoglycemic agent;
plant metabolite | 2002 | 2005 | 20.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| fructosyl-lysine | | fructosamine;
glyco-amino acid | Escherichia coli metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| etomoxir | | aromatic ether | | 2005 | 2019 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| sk&f 45905 | | | | 1996 | 1996 | 28.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| gambogic acid | | pyranoxanthones | metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pentagastrin | | organic molecular entity | | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| valencene | | carbobicyclic compound;
polycyclic olefin;
sesquiterpene | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tocol | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| mocetinostat | | aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline | antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent | 1948 | 2017 | 23.9 | low | 0 | 2 | 6 | 6 | 4 | 0 |
| fr236924 | | | | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| secoisolariciresinol diglucoside | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| tocotrienols | | diterpenoid | | 2001 | 2020 | 12.0 | low | 0 | 0 | 0 | 2 | 5 | 0 |
| zeolites | | | | 2002 | 2019 | 13.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| aluminum oxide | | | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| n-acetylcysteinamide | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| decanoylcarnitine | | decanoate ester;
O-acylcarnitine | human urinary metabolite | 1981 | 1981 | 43.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| alpha-synuclein | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 5s,12r,18r-trihydroxy-6z,8e,10e,14z,16e-eicosapentaenoic acid | | hydroxy polyunsaturated fatty acid;
long-chain fatty acid;
nonclassic icosanoid;
resolvin;
triol | anti-inflammatory agent;
human xenobiotic metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| digalactosyldiacylglycerol | | | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ribose | | D-ribose;
ribopyranose | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| acebutolol | | alpha-D-glucosyl-(1->4)-D-mannopyranose | | 1986 | 1997 | 32.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| palytoxin | | polyol | toxin | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| cardanol | | phenols | | 2012 | 2021 | 7.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| nystatin a1 | | nystatins | | 1963 | 1998 | 52.2 | low | 0 | 3 | 1 | 0 | 0 | 0 |
| linoleic acid hydroperoxide | | | | 1983 | 2022 | 28.3 | low | 0 | 4 | 9 | 1 | 0 | 1 |
| potassium cyanate | | cyanate salt;
one-carbon compound | herbicide | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| mitoquinone | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sitagliptin phosphate | | | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gw9508 | | aromatic amine | | 2007 | 2015 | 12.8 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| imidazolone | | organonitrogen heterocyclic compound | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| palmitoylcarnitine | | O-palmitoylcarnitine;
saturated fatty acyl-L-carnitine | EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
human metabolite;
mouse metabolite | 1986 | 1997 | 32.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| calcimycin | | benzoxazole | | 1982 | 2005 | 31.2 | low | 1 | 6 | 18 | 3 | 0 | 0 |
| dextrothyroxine | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sepharose | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| scopolamine hydrobromide | | | | 1993 | 1996 | 29.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| phytosterols | | | | 2000 | 2021 | 10.0 | low | 1 | 0 | 1 | 4 | 18 | 2 |
| enerbol | | | | 1958 | 1958 | 66.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| nomilin | | | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| silidianin | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| conophthorin | | ketal | | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| acid phosphatase | | | | 1964 | 2008 | 45.3 | low | 0 | 2 | 0 | 1 | 0 | 0 |
| erythrosine | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ants | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cysteinyldopa | | catecholamine;
zwitterion | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| lyoniside | | | | 2009 | 2018 | 10.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| cyanidin-3-o-beta-glucopyranoside | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 10-hydroxy-12-octadecenoic acid | | | | 1996 | 2019 | 14.1 | high | 0 | 0 | 2 | 1 | 5 | 0 |
| nad | | organophosphate oxoanion | cofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite | 1964 | 2018 | 30.9 | low | 1 | 7 | 7 | 4 | 2 | 0 |
| desmosine | | aromatic amino acid | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| protectin d1 | | dihydroxydocosahexaenoic acid;
protectin;
secondary allylic alcohol | anti-inflammatory agent;
apoptosis inhibitor;
hepatoprotective agent;
human xenobiotic metabolite;
neuroprotective agent;
PPARgamma agonist;
specialised pro-resolving mediator | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cytochrome c-t | | | | 2005 | 2016 | 14.5 | low | 0 | 0 | 0 | 6 | 2 | 0 |
| melitten | | | | 1996 | 1997 | 27.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| cholecystokinin | | | | 1999 | 2013 | 16.8 | low | 1 | 0 | 2 | 2 | 5 | 0 |
| ceruletide | | oligopeptide | diagnostic agent;
gastrointestinal drug | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| atrial natriuretic factor | | polypeptide | | 1996 | 2009 | 21.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| gastrins | | | | 1986 | 1988 | 37.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| glucagon | | peptide hormone | | 1981 | 2011 | 29.5 | low | 2 | 4 | 3 | 3 | 1 | 0 |
| neuropeptide y | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| angiotensinogen | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tannins | | | | 1994 | 2019 | 13.9 | low | 0 | 0 | 1 | 3 | 6 | 0 |
| oligonucleotides | | | | 2001 | 2004 | 21.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| glucagon-like peptide 1 | | | | 2000 | 2018 | 11.9 | low | 1 | 0 | 1 | 3 | 10 | 0 |
| c-peptide | | | | 2001 | 2012 | 18.0 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| exendin (9-39) | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cellulose | | glycoside | | 1963 | 2016 | 24.6 | low | 0 | 2 | 0 | 2 | 4 | 0 |
| endothelin-1 | | | | 2000 | 2014 | 17.4 | low | 1 | 0 | 1 | 3 | 1 | 0 |
| phosphatidylcholines | | 1,2-diacyl-sn-glycero-3-phosphocholine | | 1959 | 2022 | 30.6 | low | 10 | 70 | 83 | 22 | 21 | 4 |
| vx-770 | | aromatic amide;
monocarboxylic acid amide;
phenols;
quinolone | CFTR potentiator;
orphan drug | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| chlorophyll a | | chlorophyll;
methyl ester | cofactor | 1955 | 2022 | 24.4 | low | 0 | 4 | 0 | 1 | 4 | 2 |
| hoe 33342 | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| sphingosine kinase | | | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ubiquinone | | | | 1964 | 2014 | 22.7 | low | 0 | 1 | 2 | 3 | 3 | 0 |
| ethyl glucuronide | | beta-D-glucosiduronic acid | human urinary metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| periplocymarin | | | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| calpain | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cholesteryl ester hydroperoxide | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| lucifer yellow | | organic lithium salt | fluorochrome | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tetracosapentaenoic acid | | | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 2 | 0 | 0 |
| 9-hydroxy-12-oxo-10(e)-dodecenoic acid | | | | 2009 | 2009 | 15.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| hydroxyoctadecadienoic acid | | | | 2008 | 2021 | 10.7 | medium | 0 | 0 | 0 | 3 | 5 | 1 |
| hexadecatetraenoic acid | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| chitosan | | | | 2003 | 2023 | 10.5 | low | 0 | 0 | 0 | 8 | 14 | 3 |
| 9-(tetrahydro-2-furyl)-adenine | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bucladesine | | 3',5'-cyclic purine nucleotide | | 1986 | 1994 | 34.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| osteum | | organic molecular entity | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sodium hypochlorite | | inorganic sodium salt | bleaching agent;
disinfectant | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| sodium lactate | | lactate salt;
organic sodium salt | food acidity regulator;
food preservative | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sodium nitrite | | inorganic sodium salt;
nitrite salt | antidote to cyanide poisoning;
antihypertensive agent;
antimicrobial food preservative;
food antioxidant;
poison | 1997 | 2020 | 15.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| lactisole | | | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| stearates | | | | 1956 | 2021 | 28.3 | low | 0 | 4 | 3 | 4 | 3 | 1 |
| sodium hypophosphite | | | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| sodium glutamate | | monosodium glutamate | flavouring agent | 2007 | 2008 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| sodium ethylxanthate | | | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| mersalyl | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methyl jasmonate | | | | 2007 | 2022 | 10.2 | low | 0 | 0 | 0 | 2 | 2 | 1 |
| s-adenosylmethionine | | organic cation;
sulfonium compound | coenzyme;
cofactor;
human metabolite;
micronutrient;
Mycoplasma genitalium metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 1992 | 2013 | 23.8 | low | 2 | 0 | 3 | 1 | 1 | 0 |
| picrotoxin | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 10-nitro-oleic acid | | long-chain fatty acid;
monounsaturated fatty acid;
nitro fatty acid | human metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| egg white | | | | 1999 | 2021 | 14.0 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene | | BODIPY compound | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| cardiovascular agents | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dahlia | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| etheroleic acid | | divinyl ether fatty acid;
long-chain fatty acid | | 1995 | 2015 | 19.0 | high | 0 | 0 | 1 | 0 | 1 | 0 |
| 11,12-epoxy-5,8,14-eicosatrienoic acid | | 11,12-EET | human xenobiotic metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| lysophosphatidylserine | | 1-acyl-sn-glycero-3-phosphoserine | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| triiodothyronine, reverse | | 3,3',5'-triiodothyronine;
amino acid zwitterion | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 5,15-dihydroperoxyeicosatetraenoic acid | | | | 2005 | 2005 | 19.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| glycolipids | | | | 1963 | 2021 | 26.1 | low | 0 | 6 | 10 | 4 | 5 | 2 |
| piperidines | | | | 1984 | 2022 | 14.6 | low | 0 | 1 | 0 | 1 | 2 | 1 |
| resolvin d1 | | hydroxy polyunsaturated fatty acid;
resolvin;
triol | anti-inflammatory agent | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| interleukin-8 | | | | 1997 | 2019 | 14.9 | low | 0 | 0 | 1 | 8 | 8 | 0 |
| isosilybin | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| colistin | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| exenatide | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| kavain | | 2-pyranones;
aromatic ether | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| heme | | | | 1953 | 2022 | 26.1 | low | 0 | 3 | 1 | 6 | 1 | 1 |
| leukotoxin | | | | 1995 | 2020 | 21.8 | low | 0 | 0 | 4 | 1 | 1 | 0 |
| heparitin sulfate | | | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 9,12-dioxo-10-dodecenoic acid | | | | 2009 | 2009 | 15.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| ascorbic acid | | ascorbic acid;
vitamin C | coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent | 1964 | 2023 | 22.0 | low | 2 | 11 | 22 | 28 | 16 | 2 |
| tetracycline | | | | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| salicylates | | monohydroxybenzoate | plant metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| piroxicam | | benzothiazine;
monocarboxylic acid amide;
pyridines | analgesic;
antirheumatic drug;
cyclooxygenase 1 inhibitor;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-steroidal anti-inflammatory drug | 1991 | 2008 | 25.7 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| mobiflex | | heteroaryl hydroxy compound;
monocarboxylic acid amide;
pyridines;
thienothiazine | antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| warfarin | | benzenes;
hydroxycoumarin;
methyl ketone | | 1998 | 2012 | 16.0 | low | 0 | 0 | 1 | 0 | 3 | 0 |
| 6-o-palmitoylascorbic acid | | fatty acid ester | | 1986 | 2013 | 23.7 | low | 0 | 1 | 0 | 1 | 1 | 0 |
| arzanol | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| potassium ascorbyl tocopheryl phosphate | | | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| epidermal growth factor | | | | 1987 | 2017 | 29.1 | low | 0 | 3 | 19 | 2 | 1 | 0 |
| microcystin | | peptide | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| transforming growth factor beta | | | | 1992 | 2023 | 14.8 | low | 0 | 0 | 2 | 0 | 2 | 1 |
| okadaic acid | | ketal | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pyrethrins | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| (Z)-6,6',7,3'a-Diligustilide | | butenolide | metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sc 26196 | | | | 2001 | 2014 | 18.0 | high | 0 | 0 | 0 | 2 | 1 | 0 |
| agar | | | | 1986 | 2000 | 31.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| cyclin d1 | | | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| lysophosphatidylinositol | | | | 1985 | 2016 | 23.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| lysophosphatidylethanolamine | | | | 1986 | 1986 | 38.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| caseins | | | | 1955 | 2014 | 31.9 | low | 0 | 8 | 6 | 8 | 1 | 0 |
| oligomycins | | | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| bassianolide | | cyclodepsipeptide;
cyclooctadepsipeptide | antineoplastic agent;
fungal metabolite;
insecticide | 2014 | 2019 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| methysticin | | 2-pyranones;
aromatic ether | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glucagon-like peptide 2 | | | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| cobamamide | | | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 13-hydroperoxylinoleic acid | | hydroperoxy polyunsaturated fatty acid | | 1982 | 1999 | 31.8 | medium | 0 | 1 | 3 | 0 | 0 | 0 |
| lipofectamine | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| gibberellins | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| daptomycin | | | | 2014 | 2020 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| vitamin b 12 | | | | 1982 | 2020 | 16.4 | low | 0 | 1 | 0 | 1 | 3 | 0 |
| sermorelin | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| transforming growth factor alpha | | | | 1997 | 2014 | 18.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| moxidectin | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| arachidonoylcholine | | acylcholine | cholinergic agonist | 2020 | 2020 | 4.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| cyclosporine | | | | 2005 | 2009 | 17.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| silybin | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cytochalasin d | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| peptide yy | | | | 2010 | 2014 | 11.8 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| thromboplastin | | | | 1965 | 1985 | 49.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| muramidase | | | | 1995 | 2016 | 16.8 | low | 0 | 0 | 1 | 1 | 2 | 0 |
| amyloid beta-peptides | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| promega | | | | 1987 | 1987 | 37.0 | low | 1 | 1 | 0 | 0 | 0 | 0 |
| exudates | | | | 2013 | 2019 | 8.8 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| tetra(4-n-methylpyridyl)porphine | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| acyclovir | | 2-aminopurines;
oxopurine | antimetabolite;
antiviral drug | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| cyclic gmp | | 3',5'-cyclic purine nucleotide;
guanyl ribonucleotide | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1987 | 2002 | 29.2 | low | 0 | 1 | 3 | 2 | 0 | 0 |
| deoxyguanosine | | purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1996 | 2010 | 19.6 | low | 0 | 0 | 2 | 6 | 0 | 0 |
| 7,8-dihydroneopterin | | dihydropterin;
neopterins | Escherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| guanosine diphosphate | | guanosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate | Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor | 2001 | 2014 | 15.8 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| guanosine monophosphate | | guanosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate | biomarker;
Escherichia coli metabolite;
metabolite;
mouse metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| guanosine triphosphate | | guanosine 5'-phosphate;
purine ribonucleoside 5'-triphosphate | Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor | 1984 | 2014 | 24.3 | low | 0 | 1 | 5 | 4 | 1 | 0 |
| guanine | | 2-aminopurines;
oxopurine;
purine nucleobase | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1995 | 2008 | 22.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| hypoxanthine | | nucleobase analogue;
oxopurine;
purine nucleobase | fundamental metabolite | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| inosinic acid | | inosine phosphate;
purine ribonucleoside 5'-monophosphate | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 2022 | 2022 | 2.0 | low | 1 | 0 | 0 | 0 | 0 | 1 |
| inosine triphosphate | | inosine phosphate;
purine ribonucleoside 5'-triphosphate | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| folic acid | | folic acids;
N-acyl-amino acid | human metabolite;
mouse metabolite;
nutrient | 1964 | 2020 | 18.0 | low | 2 | 1 | 0 | 3 | 4 | 0 |
| pheophytin a | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| neopterin | | | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| clozapine | | benzodiazepine;
N-arylpiperazine;
N-methylpiperazine;
organochlorine compound | adrenergic antagonist;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
GABA antagonist;
histamine antagonist;
muscarinic antagonist;
second generation antipsychotic;
serotonergic antagonist;
xenobiotic | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| allopurinol | | nucleobase analogue;
organic heterobicyclic compound | antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger | 1982 | 2018 | 26.4 | low | 0 | 3 | 4 | 3 | 2 | 0 |
| guanylyl imidodiphosphate | | nucleoside triphosphate analogue | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| bw 540c | | | | 1988 | 1988 | 36.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| tirapazamine | | aromatic amine;
benzotriazines;
N-oxide | antibacterial agent;
antineoplastic agent;
apoptosis inducer | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 8-bromocyclic gmp | | 3',5'-cyclic purine nucleotide;
organobromine compound | muscle relaxant;
protein kinase G agonist | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| methylnitronitrosoguanidine | | nitroso compound | alkylating agent | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 8-hydroxy-2'-deoxyguanosine | | guanosines | biomarker | 1996 | 2009 | 21.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| coelenterazine | | | | 2003 | 2004 | 20.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| alpha-(4-pyridyl-1-oxide)-n-tert-butylnitrone | | | | 1986 | 1996 | 32.8 | low | 0 | 1 | 3 | 0 | 0 | 0 |
| magnesium gtp | | | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| cholestyramine resin | | | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| eye | | | | 2003 | 2003 | 21.0 | low | 1 | 0 | 0 | 2 | 0 | 0 |
| potassium magnesium aspartate | | | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| maltodextrin | | | | 2002 | 2007 | 20.5 | low | 1 | 0 | 0 | 4 | 0 | 0 |
| acetylcellulose | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| concanavalin a | | | | 1987 | 2005 | 27.3 | low | 0 | 1 | 6 | 3 | 0 | 0 |
| leptin | | | | 1999 | 2021 | 16.5 | low | 2 | 0 | 3 | 28 | 14 | 1 |
| phenanthrenes | | | | 1998 | 2002 | 23.3 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| 2019 Novel Coronavirus Disease | 0 | | 2020 | 2023 | 2.3 | low | 0 | 0 | 0 | 0 | 1 | 6 |
| Abdominal Migraine | 0 | | 1983 | 2018 | 15.0 | low | 1 | 1 | 0 | 0 | 3 | 0 |
| Abdominal Obesity | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Abetalipoproteinemia | 0 | | 1963 | 1988 | 54.2 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| Abnormalities, Autosome | 0 | | 1988 | 2003 | 30.3 | low | 0 | 1 | 1 | 1 | 0 | 0 |
| Abnormalities, Congenital | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Abnormalities, Drug-Induced | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Abnormality, Heart | 0 | | 1995 | 1999 | 27.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Abortion, Spontaneous | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Abortion, Tubal | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Absence Seizure | 0 | | 1998 | 2009 | 20.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Absence Seizure Disorder | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Academic Disorder, Developmental | 0 | | 1984 | 2006 | 29.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Acantholytic Dyskeratotic Epidermal Nevi | 0 | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Ache | 0 | | 1985 | 2022 | 14.8 | low | 0 | 2 | 1 | 5 | 8 | 2 |
| Acid beta-Glucosidase Deficiency | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Acidosis | 0 | | 1964 | 2003 | 40.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Acidosis, Diabetic | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Acne | 0 | | 1985 | 2023 | 18.3 | low | 4 | 4 | 3 | 2 | 5 | 4 |
| Acne Rosacea | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Acne Vulgaris | 0 | | 1985 | 2023 | 18.3 | low | 4 | 4 | 3 | 2 | 5 | 4 |
| Acquired Facial Neuropathy | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Acquired Immune Deficiency Syndrome | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Acquired Immunodeficiency Syndrome | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Acrodermatitis | 0 | | 1985 | 1986 | 38.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Actinic Reticuloid Syndrome | 0 | | 2006 | 2020 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Action Tremor | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Active Hyperemia | 0 | | 2015 | 2015 | 9.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| Acute Brain Injuries | 0 | | 2003 | 2023 | 12.7 | low | 0 | 0 | 0 | 2 | 0 | 1 |
| Acute Confusional Senile Dementia | 0 | | 1987 | 2023 | 12.6 | low | 0 | 1 | 0 | 3 | 7 | 1 |
| Acute Coronary Syndrome | 0 | | 2008 | 2019 | 10.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Acute Disease | 0 | | 1981 | 2022 | 24.8 | low | 5 | 3 | 4 | 3 | 2 | 1 |
| Acute Edematous Pancreatitis | 0 | | 1986 | 2019 | 26.1 | low | 2 | 2 | 5 | 0 | 2 | 0 |
| Acute Hypercapnic Respiratory Failure | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Acute Ischemic Stroke | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Acute Liver Injury, Drug-Induced | 0 | | 1963 | 2021 | 31.1 | low | 0 | 3 | 2 | 0 | 3 | 1 |
| Acute Lung Injury | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Acute Lymphoid Leukemia | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Acute Myelogenous Leukemia | 0 | | 2013 | 2023 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Acute Promyelocytic Leukemia | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Acute Respiratory Distress Syndrome | 0 | | 1994 | 2000 | 28.0 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| Acute-Phase Reaction | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ADDH | 0 | | 2004 | 2015 | 13.8 | low | 2 | 0 | 0 | 2 | 2 | 0 |
| Addison Disease and Cerebral Sclerosis | 0 | | 1994 | 2017 | 21.7 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| Addison's Anemia | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Adenocarcinoma | 0 | | 1981 | 2015 | 24.6 | low | 0 | 2 | 9 | 10 | 2 | 0 |
| Adenocarcinoma Of Kidney | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Adenocarcinoma of Lung | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Adenocarcinoma, Basal Cell | 0 | | 1981 | 2015 | 24.6 | low | 0 | 2 | 9 | 10 | 2 | 0 |
| Adenocarcinoma, Follicular | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Adenofibroma | 0 | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Adenoma | 0 | | 1990 | 2022 | 17.0 | low | 1 | 0 | 1 | 4 | 1 | 1 |
| Adenoma, Basal Cell | 0 | | 1990 | 2022 | 17.0 | low | 1 | 0 | 1 | 4 | 1 | 1 |
| Adenoma, beta-Cell | 0 | | 2002 | 2019 | 16.8 | low | 0 | 0 | 0 | 5 | 1 | 0 |
| Adenoma, Prostatic | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Adenomatous Polyposis Coli | 0 | | 1997 | 2007 | 22.0 | low | 1 | 0 | 1 | 1 | 0 | 0 |
| Adenomatous Polyposis Coli, Familial | 0 | | 1997 | 2007 | 22.0 | low | 1 | 0 | 1 | 1 | 0 | 0 |
| Adipocere | 0 | | 1993 | 2008 | 23.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Adjuvant Arthritis | 0 | | 1986 | 2023 | 21.0 | low | 0 | 1 | 3 | 0 | 1 | 1 |
| Adrenal Cortex Cancer | 0 | | 1985 | 2019 | 22.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Adrenal Cortex Neoplasms | 0 | | 1985 | 2019 | 22.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Adrenocortical Carcinoma | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Adrenoleukodystrophy | 0 | | 1994 | 2017 | 21.7 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| Adult Refsum Disease | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Advanced Sleep Phase Syndrome | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Adverse Drug Event | 0 | | 2006 | 2023 | 9.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Affective Disorders | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Affective Psychosis, Bipolar | 0 | | 2014 | 2018 | 8.0 | low | 0 | 0 | 0 | 0 | 5 | 0 |
| African Sleeping Sickness | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Age-Related Macular Degeneration | 0 | | 2001 | 2021 | 14.7 | low | 0 | 0 | 0 | 4 | 1 | 1 |
| Age-Related Memory Disorders | 0 | | 1984 | 2017 | 23.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Age-Related Osteoporosis | 0 | | 2005 | 2020 | 11.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Aging | 0 | | 1964 | 2021 | 27.4 | low | 1 | 17 | 37 | 17 | 3 | 3 |
| AIDS Seroconversion | 0 | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Airflow Obstruction, Chronic | 0 | | 2012 | 2021 | 7.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Airway Hyper-Responsiveness | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Akinetic-Rigid Variant of Huntington Disease | 0 | | 1991 | 2018 | 19.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Alactasia | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Albinism, Ocular | 0 | | 1960 | 1960 | 64.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Albuminuria | 0 | | 1992 | 1998 | 30.0 | low | 1 | 0 | 3 | 0 | 0 | 0 |
| Alcohol Abuse | 0 | | 1980 | 1992 | 37.7 | low | 0 | 7 | 2 | 0 | 0 | 0 |
| Alcohol Drinking | 0 | | 1987 | 2019 | 19.2 | low | 0 | 1 | 2 | 6 | 2 | 0 |
| Alcoholic Cirrhosis | 0 | | 1986 | 1995 | 33.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Alcoholic Fatty Liver | 0 | | 1987 | 1987 | 37.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Alcoholic Intoxication | 0 | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Alcoholic Liver Diseases | 0 | | 1986 | 2015 | 25.8 | low | 0 | 2 | 2 | 3 | 1 | 0 |
| Alcoholism | 0 | | 1980 | 1992 | 37.7 | low | 0 | 7 | 2 | 0 | 0 | 0 |
| Aldosteronism | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Allergic Contact Dermatitis | 0 | | 1995 | 2002 | 25.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Allergic Encephalomyelitis | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Allergic Reaction | 0 | | 1954 | 2017 | 31.2 | low | 0 | 4 | 2 | 2 | 2 | 0 |
| Allergy, Food | 0 | | 1999 | 2021 | 10.8 | low | 1 | 0 | 1 | 0 | 3 | 1 |
| Allergy, Peanut | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Allodynia | 0 | | 2012 | 2020 | 9.3 | low | 0 | 0 | 0 | 0 | 9 | 0 |
| Alloxan Diabetes | 0 | | 1964 | 2019 | 27.9 | low | 0 | 9 | 12 | 5 | 5 | 0 |
| Alopecia | 0 | | 2014 | 2017 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Alopecia Cicatrisata | 0 | | 2014 | 2017 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| alpha-L-Iduronidase Deficiency | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Alveolitis, Fibrosing | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Alzheimer Disease | 0 | | 1987 | 2023 | 12.6 | low | 0 | 1 | 0 | 3 | 7 | 1 |
| Amentia | 0 | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Ametropia | 0 | | 2003 | 2003 | 21.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Amino Acid Metabolism Disorders, Inborn | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Amnesia | 0 | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Amnesia-Memory Loss | 0 | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Anaphylactic Reaction | 0 | | 1994 | 2012 | 23.5 | low | 0 | 0 | 2 | 1 | 1 | 0 |
| Anaphylaxis | 0 | | 1994 | 2012 | 23.5 | low | 0 | 0 | 2 | 1 | 1 | 0 |
| Anaplastic Astrocytoma | 0 | | 1990 | 1997 | 30.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Anaplastic Ependymoma | 0 | | 1965 | 1965 | 59.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Anasarca | 0 | | 1998 | 2023 | 11.5 | low | 0 | 0 | 1 | 1 | 2 | 2 |
| Anemia | 0 | | 1955 | 2015 | 43.8 | low | 0 | 3 | 0 | 0 | 1 | 0 |
| Anemia, Cooley's | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Anemia, Hemolytic | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Anemia, Hemolytic, Acquired | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Anemia, Hypochromic | 0 | | 1955 | 1955 | 69.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Anemia, Iron-Deficiency | 0 | | 2007 | 2007 | 17.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Anemia, Sickle Cell | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Anemias, Iron-Deficiency | 0 | | 2007 | 2007 | 17.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Anesthesia | 0 | | 2008 | 2018 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Anesthesia Related Hyperthermia | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Aneurysm | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Angelman Syndrome | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Angina Pectoris | 0 | | 1965 | 1987 | 48.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Angioblastic Meningioma | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Angiogenesis, Pathologic | 0 | | 2001 | 2011 | 18.9 | low | 0 | 0 | 0 | 6 | 1 | 0 |
| Angiospasm, Intracranial | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Angor Pectoris | 0 | | 1965 | 1987 | 48.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Animal Diseases | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Animal Mammary Carcinoma | 0 | | 1965 | 2003 | 30.8 | low | 0 | 1 | 4 | 1 | 0 | 0 |
| Anorexia | 0 | | 1992 | 2012 | 22.8 | low | 0 | 0 | 2 | 1 | 1 | 0 |
| Anorexia Nervosa | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Anoxemia | 0 | | 1984 | 2022 | 21.4 | low | 0 | 2 | 1 | 0 | 1 | 1 |
| Anoxia-Ischemia, Brain | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Anterior Cervical Pain | 0 | | 2016 | 2016 | 8.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| Anterior Choroidal Artery Infarction | 0 | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Anxiety | 0 | | 1992 | 2020 | 11.9 | low | 1 | 0 | 1 | 1 | 7 | 0 |
| Anxiety Disorders | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Anxiety Neuroses | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Aortic Diseases | 0 | | 1997 | 2004 | 23.3 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| Aortic Dissection | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Aortic Stenosis | 0 | | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Aortic Valve Stenosis | 0 | | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Apnea, Obstructive Sleep | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Apolipoprotein B-100, Familial Defective | 0 | | 1981 | 2005 | 29.3 | low | 1 | 2 | 2 | 2 | 0 | 0 |
| Apolipoprotein C-II Deficiency | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Apoplexy | 0 | | 2003 | 2020 | 9.3 | low | 0 | 0 | 0 | 2 | 10 | 0 |
| Arrhythmia | 0 | | 1984 | 2003 | 33.6 | low | 0 | 5 | 1 | 1 | 0 | 0 |
| Arrhythmias, Cardiac | 0 | | 1984 | 2003 | 33.6 | low | 0 | 5 | 1 | 1 | 0 | 0 |
| Arsenic Encephalopathy | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Arterial Diseases, Carotid | 0 | | 2001 | 2021 | 16.2 | low | 0 | 0 | 0 | 3 | 1 | 1 |
| Arterial Obstructive Diseases | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Arterial Occlusive Diseases | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Arteriosclerosis | 0 | | 1957 | 2006 | 35.6 | low | 4 | 28 | 32 | 21 | 0 | 0 |
| Arteriosclerosis Obliterans | 0 | | 1986 | 1986 | 38.0 | low | 1 | 1 | 0 | 0 | 0 | 0 |
| Arteriosclerosis, Coronary | 0 | | 2001 | 2020 | 13.1 | low | 1 | 0 | 0 | 4 | 4 | 0 |
| Arthralgia | 0 | | 2006 | 2006 | 18.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Arthritis | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Arthritis, Degenerative | 0 | | 2008 | 2019 | 10.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Arthritis, Juvenile | 0 | | 2006 | 2023 | 9.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Arthritis, Juvenile Chronic | 0 | | 2006 | 2023 | 9.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Arthritis, Rheumatoid | 0 | | 1985 | 2023 | 23.0 | low | 1 | 2 | 3 | 0 | 1 | 1 |
| Ascites | 0 | | 1955 | 1964 | 63.3 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Aseptic Necrosis of Femur Head | 0 | | 2020 | 2023 | 2.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Asphyxia Neonatorum | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Asthma | 1 | | 1989 | 2023 | 16.5 | low | 1 | 1 | 4 | 3 | 4 | 3 |
| Asthma, Bronchial | 0 | | 1989 | 2023 | 16.5 | low | 1 | 1 | 4 | 3 | 4 | 3 |
| Astrocytoma | 0 | | 1990 | 1997 | 30.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Astrocytoma, Grade IV | 0 | | 1997 | 2020 | 14.8 | low | 0 | 0 | 1 | 1 | 2 | 0 |
| Asymmetric Diabetic Proximal Motor Neuropathy | 0 | | 1991 | 2008 | 26.8 | low | 0 | 0 | 3 | 2 | 0 | 0 |
| Asystole | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Ataxia | 0 | | 1964 | 1985 | 49.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Ataxia with Lactic Acidosis | 0 | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Ataxia with Lactic Acidosis 2 | 0 | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Atherogenesis | 0 | | 1958 | 2023 | 21.0 | low | 1 | 8 | 0 | 18 | 11 | 7 |
| Atheroma | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Atherosclerosis | 0 | | 1958 | 2023 | 21.0 | low | 1 | 8 | 0 | 18 | 11 | 7 |
| Atopic Hypersensitivity | 0 | | 1988 | 2002 | 27.7 | low | 0 | 1 | 3 | 2 | 0 | 0 |
| Atresia, Biliary | 0 | | 1990 | 2000 | 29.3 | low | 1 | 0 | 3 | 0 | 0 | 0 |
| Atrial Fibrillation | 0 | | 2019 | 2023 | 2.2 | low | 0 | 0 | 0 | 0 | 1 | 4 |
| Atrophy, Muscle | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Attention Deficit Disorder with Hyperactivity | 0 | | 2004 | 2015 | 13.8 | low | 2 | 0 | 0 | 2 | 2 | 0 |
| Auricular Fibrillation | 0 | | 2019 | 2023 | 2.2 | low | 0 | 0 | 0 | 0 | 1 | 4 |
| Autism | 0 | | 2001 | 2023 | 12.0 | low | 0 | 0 | 0 | 2 | 1 | 1 |
| Autism Spectrum Disorder | 0 | | 2016 | 2023 | 4.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Autistic Disorder | 0 | | 2001 | 2023 | 12.0 | low | 0 | 0 | 0 | 2 | 1 | 1 |
| Autoimmune Diabetes | 0 | | 1983 | 2021 | 27.0 | low | 2 | 7 | 7 | 2 | 2 | 2 |
| Autoimmune Disease | 0 | | 1964 | 2020 | 25.3 | low | 0 | 2 | 3 | 1 | 3 | 0 |
| Autoimmune Diseases | 0 | | 1964 | 2020 | 25.3 | low | 0 | 2 | 3 | 1 | 3 | 0 |
| Autosomal Dominant Juvenile Parkinson Disease | 0 | | 2011 | 2018 | 9.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Avitaminosis | 0 | | 1953 | 1956 | 69.0 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| B16 Melanoma | 0 | | 1990 | 2012 | 27.2 | low | 0 | 0 | 3 | 1 | 1 | 0 |
| Bacterial Disease | 0 | | 1989 | 1991 | 34.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Bacterial Infections | 0 | | 1989 | 1991 | 34.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Bacterial Infections, Gram-Positive | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Barrett Epithelium | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Barrett Esophagus | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Basophilic Leukemia, Acute | 0 | | 1992 | 1998 | 29.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Becker Muscular Dystrophy | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Benign Meningeal Neoplasms | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Benign Neoplasms | 0 | | 1955 | 2022 | 20.9 | low | 0 | 7 | 13 | 24 | 21 | 2 |
| Benign Neoplasms, Brain | 0 | | 1965 | 2018 | 22.5 | low | 1 | 1 | 3 | 3 | 3 | 0 |
| Benign Psychomotor Epilepsy, Childhood | 0 | | 1981 | 1981 | 43.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| beta-Thalassemia | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| BH4 Deficiency | 0 | | 1995 | 1998 | 27.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Bile Duct Cancer | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Bile Duct Neoplasms | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Bile Duct Obstruction | 0 | | 1988 | 2000 | 30.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Bile Duct Obstruction, Extrahepatic | 0 | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Bilharziasis | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Biliary Atresia | 0 | | 1990 | 2000 | 29.3 | low | 1 | 0 | 3 | 0 | 0 | 0 |
| Biliary Calculi | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Biliary Cirrhosis | 0 | | 1959 | 1959 | 65.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Binge Alcohol Consumption | 0 | | 2015 | 2017 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Bipolar Disorder | 0 | | 2014 | 2018 | 8.0 | low | 0 | 0 | 0 | 0 | 5 | 0 |
| Birth Weight | 0 | | 1992 | 2022 | 19.8 | low | 2 | 0 | 6 | 3 | 4 | 1 |
| Black Fever | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Bladder Cancer | 0 | | 1995 | 2004 | 23.2 | low | 0 | 0 | 1 | 3 | 0 | 0 |
| Bladder Pain Syndrome | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Bladder, Overactive | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Bleeding | 0 | | 1952 | 1995 | 59.8 | low | 0 | 3 | 1 | 0 | 0 | 0 |
| Blood Clot | 0 | | 1964 | 2022 | 28.8 | low | 0 | 3 | 8 | 1 | 1 | 1 |
| Blood Coagulation Disorders | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Blood Diseases | 0 | | 1955 | 1962 | 65.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Blood Poisoning | 0 | | 1983 | 2022 | 19.7 | low | 0 | 1 | 0 | 1 | 0 | 1 |
| Blood Pressure, High | 0 | | 1963 | 2023 | 29.0 | low | 4 | 20 | 16 | 11 | 5 | 2 |
| Blood Protein Disorders | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Body Weight | 0 | | 1960 | 2023 | 24.4 | low | 12 | 40 | 77 | 85 | 33 | 5 |
| Bone Loss, Osteoclastic | 0 | | 2003 | 2007 | 19.0 | low | 1 | 0 | 0 | 2 | 0 | 0 |
| Bovine Diseases | 0 | | 1981 | 2003 | 28.8 | low | 0 | 1 | 3 | 1 | 0 | 0 |
| Bowel Diseases, Inflammatory | 0 | | 1992 | 2023 | 16.8 | low | 1 | 0 | 1 | 3 | 1 | 1 |
| Brain Diseases | 0 | | 1960 | 1964 | 61.3 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Brain Disorders | 0 | | 1960 | 1964 | 61.3 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Brain Edema | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Brain Hemorrhage, Cerebral | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Brain Inflammation | 0 | | 2017 | 2019 | 6.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Brain Injuries | 0 | | 2003 | 2023 | 12.7 | low | 0 | 0 | 0 | 2 | 0 | 1 |
| Brain Injuries, Traumatic | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Brain Ischemia | 0 | | 1987 | 2020 | 12.0 | low | 0 | 1 | 0 | 1 | 6 | 0 |
| Brain Neoplasms | 0 | | 1965 | 2018 | 22.5 | low | 1 | 1 | 3 | 3 | 3 | 0 |
| Brain Swelling | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Brain Vascular Disorders | 0 | | 1987 | 1988 | 36.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Breast Cancer | 0 | | 1987 | 2022 | 19.2 | low | 3 | 3 | 30 | 33 | 22 | 6 |
| Breast Neoplasms | 1 | | 1987 | 2022 | 19.2 | low | 3 | 3 | 30 | 33 | 22 | 6 |
| Bright Disease | 0 | | 1985 | 1986 | 38.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Broad Beta Disease | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Bronchial Diseases | 0 | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Bronchial Hyperreactivity | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Bronchitis | 0 | | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Brucella Infection | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Brucellosis | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Burns | 0 | | 1986 | 2022 | 16.8 | low | 1 | 1 | 0 | 2 | 2 | 1 |
| Cachexia | 0 | | 1993 | 2003 | 26.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Cacosmia | 0 | | 2001 | 2007 | 20.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Cadaver | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cancer of Cervix | 0 | | 1987 | 1998 | 33.8 | low | 0 | 3 | 1 | 0 | 0 | 0 |
| Cancer of Colon | 0 | | 1984 | 2023 | 20.2 | low | 0 | 1 | 16 | 19 | 7 | 2 |
| Cancer of Endometrium | 0 | | 1994 | 2018 | 16.0 | low | 0 | 0 | 1 | 1 | 2 | 0 |
| Cancer of Esophagus | 0 | | 1995 | 2011 | 20.6 | low | 0 | 0 | 2 | 2 | 1 | 0 |
| Cancer of Eye | 0 | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Cancer of Head | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cancer of Intestines | 0 | | 2000 | 2004 | 22.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Cancer of Kidney | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Cancer of Larynx | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cancer of Liver | 0 | | 1984 | 2022 | 17.6 | low | 1 | 2 | 9 | 12 | 10 | 4 |
| Cancer of Lung | 0 | | 1987 | 2023 | 22.2 | low | 0 | 4 | 10 | 6 | 3 | 3 |
| Cancer of Mouth | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cancer of Oropharnyx | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cancer of Ovary | 0 | | 1963 | 2022 | 18.7 | low | 0 | 1 | 1 | 0 | 2 | 2 |
| Cancer of Pancreas | 0 | | 1985 | 2008 | 24.9 | low | 1 | 1 | 7 | 7 | 0 | 0 |
| Cancer of Prostate | 0 | | 1989 | 2020 | 20.4 | low | 1 | 1 | 11 | 18 | 7 | 0 |
| Cancer of Rectum | 0 | | 1999 | 2019 | 15.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Cancer of Sigmoid | 0 | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cancer of Skin | 0 | | 1987 | 2009 | 24.2 | low | 0 | 2 | 8 | 7 | 0 | 0 |
| Cancer of Stomach | 0 | | 1986 | 2013 | 20.1 | low | 0 | 1 | 2 | 10 | 3 | 0 |
| Cancer of the Thymus | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cancer of the Thyroid | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cancer of the Uterus | 0 | | 1985 | 2000 | 31.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Cancer, Radiation-Induced | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Candida Infection | 0 | | 2006 | 2023 | 9.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Candidiasis | 0 | | 2006 | 2023 | 9.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Candidiasis, Genital | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Candidiasis, Vulvovaginal | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cane-Cutter Fever | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Canine Diseases | 0 | | 1992 | 2023 | 20.5 | low | 0 | 0 | 4 | 0 | 1 | 1 |
| Carbohydrate Inducible Hyperlipemia | 0 | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Carbon Tetrachloride Poisoning | 0 | | 1964 | 2012 | 38.4 | low | 0 | 4 | 0 | 0 | 1 | 0 |
| Carcinogenesis | 0 | | 2014 | 2022 | 6.3 | low | 0 | 0 | 0 | 0 | 6 | 1 |
| Carcinoma | 0 | | 1990 | 2010 | 24.7 | low | 0 | 0 | 3 | 4 | 0 | 0 |
| Carcinoma 256, Walker | 0 | | 1997 | 1999 | 26.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Carcinoma in Situ | 0 | | 1989 | 1997 | 31.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Carcinoma, Anaplastic | 0 | | 1990 | 2010 | 24.7 | low | 0 | 0 | 3 | 4 | 0 | 0 |
| Carcinoma, Basal Cell | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Carcinoma, Basal Cell, Pigmented | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Carcinoma, Ductal, Breast | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Carcinoma, Ductal, Pancreatic | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Carcinoma, Ehrlich Tumor | 0 | | 1955 | 1994 | 44.1 | low | 0 | 6 | 1 | 0 | 0 | 0 |
| Carcinoma, Epidermoid | 0 | | 1995 | 2015 | 20.3 | low | 0 | 0 | 4 | 3 | 2 | 0 |
| Carcinoma, Hepatocellular | 0 | | 1984 | 2022 | 18.2 | low | 0 | 2 | 6 | 12 | 8 | 2 |
| Carcinoma, Intraepithelial | 0 | | 1989 | 1997 | 31.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Carcinoma, Krebs 2 | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Carcinoma, Lewis Lung | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Carcinoma, Non-Small Cell Lung | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Carcinoma, Non-Small-Cell Lung | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Carcinoma, Pancreatic Ductal | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Carcinoma, Renal Cell | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Carcinoma, Squamous Cell | 0 | | 1995 | 2015 | 20.3 | low | 0 | 0 | 4 | 3 | 2 | 0 |
| Carcinoma, Thymic | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cardiac Arrest, Sudden | 0 | | 1995 | 2007 | 23.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Cardiac Complex, Premature | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Cardiac Death | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cardiac Diseases | 0 | | 1965 | 2001 | 38.3 | low | 0 | 1 | 1 | 1 | 0 | 0 |
| Cardiac Failure | 0 | | 1964 | 2022 | 15.8 | low | 1 | 1 | 1 | 2 | 6 | 2 |
| Cardiac Neurosis | 0 | | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Cardiac Remodeling, Ventricular | 0 | | 2019 | 2019 | 5.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| Cardiometabolic Syndrome | 0 | | 2002 | 2022 | 10.9 | low | 3 | 0 | 0 | 8 | 11 | 2 |
| Cardiomyopathies | 0 | | 1985 | 2010 | 23.5 | low | 0 | 1 | 1 | 2 | 0 | 0 |
| Cardiomyopathies, Primary | 0 | | 1985 | 2010 | 23.5 | low | 0 | 1 | 1 | 2 | 0 | 0 |
| Cardiomyopathy, Congestive | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cardiomyopathy, Dilated | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cardiovascular Diseases | 0 | | 1985 | 2023 | 14.0 | low | 11 | 1 | 6 | 23 | 25 | 5 |
| Cardiovascular Pregnancy Complications | 0 | | 1985 | 2018 | 21.8 | low | 2 | 1 | 0 | 2 | 1 | 0 |
| Cardiovascular Stroke | 0 | | 1963 | 2022 | 25.7 | low | 3 | 10 | 3 | 8 | 5 | 3 |
| Caries, Dental | 0 | | 1982 | 2014 | 26.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Carotid Artery Diseases | 0 | | 2001 | 2021 | 16.2 | low | 0 | 0 | 0 | 3 | 1 | 1 |
| Cartilage Diseases | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cat Diseases | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cataract | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cataract, Membranous | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Celiac Disease | 0 | | 1963 | 2000 | 53.0 | low | 1 | 4 | 1 | 0 | 0 | 0 |
| Celiac Sprue | 0 | | 1963 | 2000 | 53.0 | low | 1 | 4 | 1 | 0 | 0 | 0 |
| Cell Transformation, Neoplastic | 0 | | 1982 | 2015 | 23.2 | low | 0 | 2 | 6 | 7 | 1 | 0 |
| Cell Transformation, Viral | 0 | | 1985 | 1990 | 36.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Central Hypothyroidism | 0 | | 1964 | 1988 | 52.0 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Central Nervous System Disease | 0 | | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Central Nervous System Diseases | 0 | | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Central Nervous System Syphilis | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Centriacinar Emphysema | 0 | | 2017 | 2017 | 7.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| Cerebellar Diseases | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cerebral Hemorrhage | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cerebral Infarction | 0 | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Cerebral Ischemia | 0 | | 1987 | 2020 | 12.0 | low | 0 | 1 | 0 | 1 | 6 | 0 |
| Cerebral Malaria | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cerebral Pseudosclerosis | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cerebromalacia | 0 | | 1960 | 1995 | 46.0 | low | 0 | 2 | 2 | 0 | 0 | 0 |
| Cerebrovascular Disorders | 0 | | 1987 | 1988 | 36.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Chemical and Drug Induced Liver Injury | 0 | | 1963 | 2021 | 31.1 | low | 0 | 3 | 2 | 0 | 3 | 1 |
| Chemical and Drug Induced Liver Injury, Chronic | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Child Development Disorders, Pervasive | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Child Malnutrition | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Chloasma | 0 | | 2002 | 2012 | 17.0 | low | 1 | 0 | 0 | 1 | 1 | 0 |
| Cholangiocarcinoma | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cholangiocellular Carcinoma | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cholangitis | 0 | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cholelithiasis | 0 | | 1963 | 1987 | 52.7 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Cholera Infantum | 0 | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cholestasis | 0 | | 1988 | 2000 | 30.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Choline Deficiency | 0 | | 1965 | 1965 | 59.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Chondromalacia | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Chorea | 0 | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Chorea Disorders | 0 | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Choriocarcinoma | 0 | | 1997 | 2000 | 25.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Choroid Neovascularization | 0 | | 2007 | 2014 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Chromosome-Defective Micronuclei | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Chronic Disease | 0 | | 1987 | 2023 | 24.1 | low | 1 | 2 | 6 | 2 | 1 | 1 |
| Chronic Hepatitis C | 0 | | 2000 | 2000 | 24.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| Chronic Illness | 0 | | 1987 | 2023 | 24.1 | low | 1 | 2 | 6 | 2 | 1 | 1 |
| Chronic Kidney Diseases | 0 | | 2014 | 2018 | 8.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Chronic Kidney Failure | 0 | | 1983 | 2005 | 29.4 | low | 0 | 3 | 3 | 2 | 0 | 0 |
| Chronic Pain | 0 | | 2016 | 2022 | 5.0 | low | 1 | 0 | 0 | 0 | 1 | 1 |
| Cicatrix, Hypertrophic | 0 | | 2008 | 2008 | 16.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Circoviridae Infections | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cirrhoses, Experimental Liver | 0 | | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Cirrhosis | 0 | | 2003 | 2023 | 11.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Cirrhosis, Liver | 0 | | 1959 | 2023 | 36.0 | low | 1 | 5 | 3 | 1 | 0 | 1 |
| CJD (Creutzfeldt-Jakob Disease) | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cleft Lip | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Clinically Isolated CNS Demyelinating Syndrome | 0 | | 2005 | 2023 | 10.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Coagulation Disorders, Blood | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Coagulation, Disseminated Intravascular | 0 | | 1988 | 2020 | 20.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Cocaine Abuse | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cocaine-Related Disorders | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cocarcinogenesis | 0 | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Cognitive Decline | 0 | | 2018 | 2020 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Cognitive Dysfunction | 0 | | 2018 | 2020 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Colitis | 0 | | 1996 | 2023 | 9.8 | low | 0 | 0 | 1 | 1 | 7 | 3 |
| Colitis Gravis | 0 | | 1985 | 2022 | 15.2 | low | 0 | 1 | 0 | 2 | 1 | 1 |
| Colitis, Granulomatous | 0 | | 1985 | 2023 | 25.2 | low | 2 | 3 | 3 | 5 | 0 | 1 |
| Colitis, Ulcerative | 0 | | 1985 | 2022 | 15.2 | low | 0 | 1 | 0 | 2 | 1 | 1 |
| Collodion Baby Syndrome | 0 | | 2022 | 2023 | 1.5 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Colonic Diseases | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Colonic Inertia | 0 | | 2007 | 2007 | 17.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Colonic Neoplasms | 0 | | 1984 | 2023 | 20.2 | low | 0 | 1 | 16 | 19 | 7 | 2 |
| Colorectal Cancer | 0 | | 1990 | 2022 | 13.5 | low | 4 | 0 | 4 | 12 | 10 | 5 |
| Colorectal Neoplasms | 0 | | 1990 | 2022 | 13.5 | low | 4 | 0 | 4 | 12 | 10 | 5 |
| Communicable Diseases | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Community Acquired Infection | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Compensatory Hyperinsulinemia | 0 | | 2002 | 2017 | 17.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Complication, Postoperative | 0 | | 1986 | 1994 | 34.0 | low | 1 | 1 | 1 | 0 | 0 | 0 |
| Complications of Diabetes Mellitus | 0 | | 1984 | 2003 | 33.0 | low | 0 | 2 | 1 | 1 | 0 | 0 |
| Complications, Neoplastic Pregnancy | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Complications, Pregnancy | 0 | | 1981 | 2020 | 26.4 | low | 0 | 2 | 3 | 0 | 2 | 0 |
| Condition, Preneoplastic | 0 | | 1987 | 2017 | 26.6 | low | 0 | 3 | 4 | 3 | 1 | 0 |
| Congenital Fissure of the Abdominal Cavity | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Congenital Icthyosis Mental Retardation Spasticity Syndrome | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Congenital Zika Syndrome | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Constipation | 0 | | 2007 | 2007 | 17.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Contact Dermatitis | 0 | | 1989 | 1995 | 32.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Convulsions, Grand Mal | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Coronary Artery Disease | 0 | | 2001 | 2020 | 13.1 | low | 1 | 0 | 0 | 4 | 4 | 0 |
| Coronary Disease | 0 | | 1965 | 2022 | 22.9 | low | 3 | 11 | 23 | 16 | 21 | 1 |
| Coronary Heart Disease | 0 | | 1965 | 2022 | 22.9 | low | 3 | 11 | 23 | 16 | 21 | 1 |
| Coronary Restenosis | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Coronary Thrombosis | 0 | | 1997 | 2019 | 16.0 | low | 1 | 0 | 1 | 0 | 1 | 0 |
| Coronavirus Infections | 0 | | 2020 | 2023 | 2.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Cot Death | 0 | | 1994 | 1995 | 29.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Creutzfeldt-Jakob Syndrome | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Critical Illness | 0 | | 1997 | 2018 | 19.3 | low | 0 | 0 | 2 | 0 | 1 | 0 |
| Crohn Disease | 0 | | 1985 | 2023 | 25.2 | low | 2 | 3 | 3 | 5 | 0 | 1 |
| Cross Infection | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cyclitis, Heterochromic | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cystadenocarcinoma, Serous | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cystic Fibrosis | 0 | | 1981 | 2022 | 21.0 | low | 7 | 8 | 8 | 13 | 6 | 3 |
| Cystic Fibrosis of Pancreas | 0 | | 1981 | 2022 | 21.0 | low | 7 | 8 | 8 | 13 | 6 | 3 |
| Cystic Kidney Diseases | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cystitis, Interstitial | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cytomegalovirus | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Death, Sudden | 0 | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Death, Sudden, Cardiac | 0 | | 1995 | 2007 | 23.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Deficiency Disease, Ornithine Carbamoyltransferase | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Deficiency Diseases | 0 | | 1963 | 2015 | 41.8 | low | 1 | 10 | 1 | 1 | 4 | 0 |
| Deficiency, Magnesium | 0 | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Deficiency, Mental | 0 | | 2001 | 2023 | 12.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Deficiency, Protein | 0 | | 1964 | 1991 | 53.2 | low | 0 | 3 | 1 | 0 | 0 | 0 |
| Deficiency, Pyridoxine | 0 | | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Deficiency, Thiamine | 0 | | 1965 | 1965 | 59.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Deficiency, Vitamin A | 0 | | 1995 | 2000 | 26.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Deficiency, Vitamin D | 0 | | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Deficiency, Vitamin E | 0 | | 1958 | 2011 | 38.5 | low | 0 | 9 | 7 | 1 | 1 | 0 |
| Degenerative Diseases, Central Nervous System | 0 | | 2011 | 2022 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Dehydration | 0 | | 2018 | 2020 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Delayed Effects, Prenatal Exposure | 0 | | 1984 | 2022 | 20.6 | low | 0 | 1 | 3 | 3 | 0 | 2 |
| Delayed Hypersensitivity | 0 | | 2001 | 2003 | 21.5 | low | 1 | 0 | 0 | 4 | 0 | 0 |
| Dementia | 0 | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Dementia Praecox | 0 | | 1981 | 2018 | 21.2 | low | 0 | 2 | 2 | 0 | 4 | 0 |
| Demyelinating Diseases | 0 | | 2005 | 2023 | 10.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Dental Caries | 0 | | 1982 | 2014 | 26.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Dental Plaque | 0 | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Depression | 0 | | 1992 | 2023 | 8.9 | low | 1 | 0 | 1 | 1 | 9 | 2 |
| Depression, Endogenous | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Depression, Involutional | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Depressive Disorder | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Depressive Disorder, Major | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Dermatitis | 0 | | 1950 | 2018 | 30.4 | low | 0 | 4 | 0 | 2 | 4 | 0 |
| Dermatitis Medicamentosa | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Dermatitis Seborrheica | 0 | | 1957 | 1957 | 67.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Dermatitis, Allergic Contact | 0 | | 1995 | 2002 | 25.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Dermatitis, Atopic | 0 | | 1952 | 2021 | 23.0 | low | 4 | 5 | 7 | 3 | 6 | 2 |
| Dermatitis, Contact | 0 | | 1989 | 1995 | 32.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Dermatitis, Contact, Phototoxic | 0 | | 1995 | 2008 | 21.1 | low | 0 | 0 | 3 | 6 | 0 | 0 |
| Dermatitis, Eczematous | 0 | | 1950 | 2019 | 41.2 | low | 2 | 4 | 2 | 1 | 1 | 0 |
| Dermatitis, Irritant | 0 | | 1995 | 1995 | 29.0 | low | 1 | 0 | 2 | 0 | 0 | 0 |
| Dermatitis, Poison Ivy | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Dermatitis, Radiation-Induced | 0 | | 1964 | 2009 | 37.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Dermatitis, Seborrheic | 0 | | 1957 | 1957 | 67.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Dermatomycoses | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Dermatoses | 0 | | 1993 | 2020 | 14.8 | low | 1 | 0 | 2 | 1 | 3 | 0 |
| Devic Disease | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Di Guglielmo Disease | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Diabetes Mellitus | 0 | | 1963 | 2020 | 28.4 | low | 2 | 9 | 6 | 11 | 5 | 0 |
| Diabetes Mellitus, Adult-Onset | 0 | | 1984 | 2023 | 17.2 | low | 7 | 4 | 8 | 19 | 19 | 3 |
| Diabetes Mellitus, Gestational | 0 | | 2018 | 2022 | 3.8 | low | 1 | 0 | 0 | 0 | 2 | 2 |
| Diabetes Mellitus, Type 1 | 0 | | 1983 | 2021 | 27.0 | low | 2 | 7 | 7 | 2 | 2 | 2 |
| Diabetes Mellitus, Type 2 | 1 | | 1984 | 2023 | 17.2 | low | 7 | 4 | 8 | 19 | 19 | 3 |
| Diabetes, Gestational | 0 | | 2018 | 2022 | 3.8 | low | 1 | 0 | 0 | 0 | 2 | 2 |
| Diabetic Angiopathies | 0 | | 1964 | 2004 | 35.1 | low | 0 | 3 | 2 | 2 | 0 | 0 |
| Diabetic Glomerulosclerosis | 0 | | 1992 | 2018 | 18.5 | low | 0 | 0 | 2 | 0 | 2 | 0 |
| Diabetic Ketoacidosis | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Diabetic Nephropathies | 0 | | 1992 | 2018 | 18.5 | low | 0 | 0 | 2 | 0 | 2 | 0 |
| Diabetic Neuropathies | 0 | | 1991 | 2008 | 26.8 | low | 0 | 0 | 3 | 2 | 0 | 0 |
| Diabetic Retinopathy | 0 | | 1983 | 1995 | 36.8 | low | 1 | 3 | 1 | 0 | 0 | 0 |
| Diarrhea | 0 | | 1986 | 1993 | 34.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Diathesis | 0 | | 2006 | 2020 | 11.0 | low | 0 | 0 | 0 | 2 | 4 | 0 |
| Diffuse Mixed Small and Large Cell Lymphoma | 0 | | 2006 | 2013 | 14.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Disbacteriosis | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Disease | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Disease Exacerbation | 0 | | 1995 | 2022 | 15.4 | low | 1 | 0 | 3 | 6 | 7 | 1 |
| Disease Models, Animal | 0 | | 1987 | 2023 | 15.1 | low | 0 | 3 | 20 | 23 | 49 | 4 |
| Disease Resistance | 0 | | 2014 | 2023 | 5.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Disease, Pulmonary | 0 | | 1963 | 1963 | 61.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Diseases of Immune System | 0 | | 1954 | 2001 | 50.2 | low | 0 | 3 | 0 | 1 | 0 | 0 |
| Diseases, Metabolic | 0 | | 1993 | 2022 | 10.5 | low | 0 | 0 | 1 | 0 | 2 | 1 |
| Diseases, Peripheral Vascular | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Disseminated Intravascular Coagulation | 0 | | 1988 | 2020 | 20.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Drug Withdrawal Symptoms | 0 | | 1985 | 1987 | 38.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Drug-Related Side Effects and Adverse Reactions | 0 | | 2006 | 2023 | 9.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Dry Eye | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Dry Eye Syndromes | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Dyslipidemia | 0 | | 2006 | 2020 | 10.3 | low | 1 | 0 | 0 | 2 | 4 | 0 |
| Dyslipidemias | 0 | | 2006 | 2020 | 10.3 | low | 1 | 0 | 0 | 2 | 4 | 0 |
| E coli Infections | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Eczema | 0 | | 1950 | 2019 | 41.2 | low | 2 | 4 | 2 | 1 | 1 | 0 |
| Eczema, Atopic | 0 | | 1952 | 2021 | 23.0 | low | 4 | 5 | 7 | 3 | 6 | 2 |
| Edema | 0 | | 1998 | 2023 | 11.5 | low | 0 | 0 | 1 | 1 | 2 | 2 |
| Edema-Proteinuria-Hypertension Gestosis | 0 | | 1985 | 2018 | 20.2 | low | 1 | 2 | 3 | 5 | 4 | 0 |
| EHS Tumor | 0 | | 1962 | 1998 | 44.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Electrolytes | 0 | | 1964 | 2007 | 37.0 | low | 2 | 3 | 2 | 1 | 0 | 0 |
| Electron Transport Chain Deficiencies, Mitochondrial | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Elevated Cholesterol | 0 | | 1960 | 2023 | 28.6 | low | 11 | 8 | 15 | 9 | 6 | 2 |
| Embolism, Fat | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Encephalitis | 0 | | 2017 | 2019 | 6.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Encephalitis, Polio | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Encephalopathy, Hepatic | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Encephalopathy, Traumatic | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Encopresis | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Endometrial Neoplasms | 0 | | 1994 | 2018 | 16.0 | low | 0 | 0 | 1 | 1 | 2 | 0 |
| Endometrioma | 0 | | 2008 | 2018 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Endometriosis | 0 | | 2008 | 2018 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Endotoxemia | 0 | | 1998 | 1999 | 25.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Endotoxin Shock | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Enlarged Liver | 0 | | 2004 | 2009 | 17.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Enlarged Spleen | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Enterically-Transmitted Non-A, Non-B Hepatitis | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Enteritis | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Enterocolitis, Necrotizing | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Enuresis | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Eosinophilia | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Eosinophilia, Tropical | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Ependymoma | 0 | | 1965 | 1965 | 59.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Epilepsy, Absence | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Epilepsy, Temporal Lobe | 0 | | 1981 | 1981 | 43.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Epilepsy, Tonic-Clonic | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ER-Negative PR-Negative HER2-Negative Breast Cancer | 0 | | 2018 | 2020 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Escherichia coli Infections | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Esophageal Neoplasms | 0 | | 1995 | 2011 | 20.6 | low | 0 | 0 | 2 | 2 | 1 | 0 |
| Esophageal Reflux | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Esophagitis, Peptic | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Esophagitis, Reflux | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Exocrine Pancreatic Insufficiency | 0 | | 1985 | 2016 | 26.4 | low | 1 | 3 | 0 | 0 | 2 | 0 |
| Experimental Hepatoma | 0 | | 1982 | 2015 | 28.5 | low | 0 | 8 | 8 | 8 | 1 | 0 |
| Experimental Leukemia | 0 | | 1981 | 1996 | 37.8 | low | 0 | 3 | 1 | 0 | 0 | 0 |
| Experimental Lung Inflammation | 0 | | 1985 | 2006 | 25.3 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| Experimental Mammary Neoplasms | 0 | | 1965 | 2017 | 29.9 | low | 0 | 12 | 30 | 5 | 1 | 0 |
| Experimental Neoplasms | 0 | | 1981 | 2019 | 27.7 | low | 0 | 4 | 4 | 4 | 1 | 0 |
| Experimental Radiation Injuries | 0 | | 1963 | 2009 | 41.5 | low | 0 | 2 | 1 | 1 | 0 | 0 |
| External Ear Inflammation | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Extramembranous Glomerulopathy | 0 | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Extravascular Hemolysis | 0 | | 1964 | 2022 | 24.6 | low | 0 | 5 | 12 | 11 | 5 | 1 |
| Eye Cancer, Retinoblastoma | 0 | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Eyelid Diseases | 0 | | 2007 | 2016 | 12.5 | low | 1 | 0 | 0 | 1 | 1 | 0 |
| Fallot's Tetralogy | 0 | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Familial Combined Hyperlipidemia | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Familial Nonmedullary Thyroid Cancer | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Fasting Hypoglycemia | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Fat Necrosis | 0 | | 2013 | 2019 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Fatigue | 0 | | 2014 | 2014 | 10.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| Fatty Liver | 0 | | 1963 | 2020 | 24.7 | low | 1 | 7 | 2 | 12 | 8 | 0 |
| Fatty Liver with Encephalopathy | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Fatty Liver, Nonalcoholic | 0 | | 2010 | 2023 | 5.4 | low | 1 | 0 | 0 | 1 | 6 | 6 |
| Fetal Growth Restriction | 0 | | 2002 | 2005 | 20.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Fetal Growth Retardation | 0 | | 2002 | 2005 | 20.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Fibroma, Shope | 0 | | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Fibrosarcoma | 0 | | 1984 | 1998 | 34.2 | low | 0 | 3 | 1 | 0 | 0 | 0 |
| Fibrosis | 0 | | 2003 | 2023 | 11.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Fish Diseases | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Fistula | 0 | | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Focal Neurologic Deficits | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Follicular Thyroid Carcinoma | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Food Hypersensitivity | 0 | | 1999 | 2021 | 10.8 | low | 1 | 0 | 1 | 0 | 3 | 1 |
| Foreign-Body Reaction | 0 | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Fra(X) Syndrome | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Fragile X Syndrome | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Friedreich Ataxia | 0 | | 1982 | 2023 | 24.6 | low | 6 | 5 | 0 | 0 | 2 | 2 |
| Friedreich Disease | 0 | | 1982 | 2023 | 24.6 | low | 6 | 5 | 0 | 0 | 2 | 2 |
| Fusiform Aneurysm | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Gall Bladder Diseases | 0 | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Gallstone Disease | 0 | | 1963 | 1987 | 52.7 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Gallstones | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Gastric Ulcer | 0 | | 1988 | 2022 | 18.8 | low | 0 | 1 | 1 | 1 | 1 | 1 |
| Gastritis | 0 | | 2001 | 2003 | 22.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Gastroduodenal Ulcer | 0 | | 1993 | 1994 | 30.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Gastroesophageal Reflux | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Gastrointestinal Hemorrhage | 0 | | 1986 | 1989 | 36.7 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Gastroschisis | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Gaucher Disease | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Genetic Diseases, X-Chromosome Linked | 0 | | 1960 | 2003 | 42.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Genetic Predisposition | 0 | | 2001 | 2021 | 9.5 | low | 0 | 0 | 0 | 4 | 6 | 1 |
| Genital Diseases, Male | 0 | | 1994 | 1994 | 30.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| Germinoblastoma | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Gestational Hypertension | 0 | | 2005 | 2005 | 19.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Glial Cell Tumors | 0 | | 1965 | 2020 | 24.7 | low | 1 | 4 | 2 | 3 | 4 | 0 |
| Glioblastoma | 0 | | 1997 | 2020 | 14.8 | low | 0 | 0 | 1 | 1 | 2 | 0 |
| Glioma | 0 | | 1965 | 2020 | 24.7 | low | 1 | 4 | 2 | 3 | 4 | 0 |
| Glomerulonephritis | 0 | | 1985 | 1986 | 38.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Glomerulonephritis, Membranous | 0 | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Glucose Intolerance | 0 | | 2002 | 2023 | 12.2 | low | 0 | 0 | 0 | 3 | 2 | 1 |
| Goldblatt Syndrome | 0 | | 1984 | 1989 | 37.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Gram-Positive Bacterial Infections | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Granuloma | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Granulomas | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Great Pox | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Group A Strep Infection | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Growth Disorders | 0 | | 1996 | 2018 | 17.8 | low | 1 | 0 | 2 | 1 | 2 | 0 |
| Haemophilus Infections | 0 | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Hand Dermatoses | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hand Dermatosis | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hansen Disease | 0 | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Happy Puppet Syndrome | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Harelip | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hay Fever | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| HbS Disease | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Head and Neck Neoplasms | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Health Care Associated Infection | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Heart Arrest | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Heart Defects, Congenital | 0 | | 1995 | 1999 | 27.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Heart Disease, Ischemic | 0 | | 1993 | 2019 | 19.0 | low | 0 | 0 | 3 | 1 | 3 | 0 |
| Heart Diseases | 0 | | 1965 | 2001 | 38.3 | low | 0 | 1 | 1 | 1 | 0 | 0 |
| Heart Failure | 0 | | 1964 | 2022 | 15.8 | low | 1 | 1 | 1 | 2 | 6 | 2 |
| Helicobacter Infections | 0 | | 2001 | 2022 | 13.4 | low | 0 | 0 | 0 | 3 | 1 | 1 |
| Hematochezia | 0 | | 1986 | 1989 | 36.7 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Hematologic Diseases | 0 | | 1955 | 1962 | 65.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Hemolysis | 0 | | 1964 | 2022 | 24.6 | low | 0 | 5 | 12 | 11 | 5 | 1 |
| Hemorrhage | 0 | | 1952 | 1995 | 59.8 | low | 0 | 3 | 1 | 0 | 0 | 0 |
| Hemorrhage, Retinal | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Hemorrhage, Subarachnoid | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hepatic Encephalopathy | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Hepatic Failure | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Hepatitis | 0 | | 1963 | 2004 | 50.0 | low | 0 | 3 | 0 | 1 | 0 | 0 |
| Hepatitis A | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Hepatitis C, Chronic | 0 | | 2000 | 2000 | 24.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| Hepatitis E | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Hepatitis, Animal | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Hepatitis, Infectious | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Hepatocellular Carcinoma | 0 | | 1984 | 2022 | 18.2 | low | 0 | 2 | 6 | 12 | 8 | 2 |
| Hepatolenticular Degeneration | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Heroin Abuse | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Heroin Dependence | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hibernation, Myocardial | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Hip Fractures | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| HIV Coinfection | 0 | | 1995 | 2006 | 25.0 | low | 1 | 0 | 3 | 1 | 0 | 0 |
| HIV Infections | 0 | | 1995 | 2006 | 25.0 | low | 1 | 0 | 3 | 1 | 0 | 0 |
| Hives | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Hormone-Dependent Neoplasms | 0 | | 1983 | 2008 | 26.5 | low | 0 | 1 | 2 | 3 | 0 | 0 |
| HPV Infection | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Huntington Disease | 0 | | 1991 | 2018 | 19.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Hyperaldosteronism | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hyperandrogenism | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hypercholesterolemia | 0 | | 1960 | 2023 | 28.6 | low | 11 | 8 | 15 | 9 | 6 | 2 |
| Hyperchylomicronemia Late Onset | 0 | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Hyperemia | 0 | | 2015 | 2015 | 9.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| Hyperglycemia | 0 | | 1990 | 2022 | 16.1 | low | 0 | 0 | 1 | 2 | 3 | 1 |
| Hyperglycemia, Postprandial | 0 | | 1990 | 2022 | 16.1 | low | 0 | 0 | 1 | 2 | 3 | 1 |
| Hyperinsulinism | 0 | | 2002 | 2017 | 17.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Hyperkeratosis Palmaris et Plantaris | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hyperlipemia | 0 | | 1963 | 2022 | 27.9 | low | 7 | 8 | 6 | 8 | 6 | 2 |
| Hyperlipidemia, Familial Combined | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hyperlipidemias | 0 | | 1963 | 2022 | 27.9 | low | 7 | 8 | 6 | 8 | 6 | 2 |
| Hyperlipoproteinemia | 0 | | 1985 | 1990 | 37.0 | low | 0 | 4 | 1 | 0 | 0 | 0 |
| Hyperlipoproteinemia Type I | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Hyperlipoproteinemia Type II | 0 | | 1981 | 2005 | 29.3 | low | 1 | 2 | 2 | 2 | 0 | 0 |
| Hyperlipoproteinemia Type III | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Hyperlipoproteinemia Type IV | 0 | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Hyperlipoproteinemias | 0 | | 1985 | 1990 | 37.0 | low | 0 | 4 | 1 | 0 | 0 | 0 |
| Hypermelanosis | 0 | | 1998 | 2004 | 23.0 | low | 1 | 0 | 1 | 1 | 0 | 0 |
| Hyperphagia | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Hyperpigmentation | 0 | | 1998 | 2004 | 23.0 | low | 1 | 0 | 1 | 1 | 0 | 0 |
| Hyperplasia | 0 | | 1987 | 2011 | 24.3 | low | 0 | 1 | 4 | 3 | 1 | 0 |
| Hypersensitivity | 0 | | 1954 | 2017 | 31.2 | low | 0 | 4 | 2 | 2 | 2 | 0 |
| Hypersensitivity, Type III | 0 | | 1985 | 1986 | 38.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Hypertension | 0 | | 1963 | 2023 | 29.0 | low | 4 | 20 | 16 | 11 | 5 | 2 |
| Hypertension, Pregnancy-Induced | 0 | | 2005 | 2005 | 19.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Hypertension, Pulmonary | 0 | | 1996 | 2023 | 14.5 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| Hypertension, Renal | 0 | | 1963 | 2004 | 40.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Hypertension, Renovascular | 0 | | 1984 | 1989 | 37.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Hypertriglyceridemia | 0 | | 1965 | 2018 | 23.4 | low | 2 | 1 | 1 | 5 | 2 | 0 |
| Hypertrophy | 0 | | 1989 | 2010 | 24.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Hypertrophy, Left Ventricular | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hyperuricemia | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Hypervitaminosis A | 0 | | 1965 | 1965 | 59.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Hypocalcemia | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Hypoglycemia | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hypothyroidism | 0 | | 1964 | 1988 | 52.0 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| Hypoxia | 0 | | 1984 | 2022 | 21.4 | low | 0 | 2 | 1 | 0 | 1 | 1 |
| Hypoxia-Ischemia, Brain | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Ichthyosis | 0 | | 1986 | 2022 | 14.0 | low | 0 | 1 | 0 | 0 | 0 | 2 |
| Ichthyosis, Lamellar | 0 | | 2022 | 2023 | 1.5 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Icterus Gravis Neonatorum | 0 | | 1994 | 1994 | 30.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| Idiopathic Parkinson Disease | 0 | | 2011 | 2022 | 6.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Immune System Diseases | 0 | | 1954 | 2001 | 50.2 | low | 0 | 3 | 0 | 1 | 0 | 0 |
| Impaired Glucose Tolerance | 0 | | 2002 | 2023 | 12.2 | low | 0 | 0 | 0 | 3 | 2 | 1 |
| Inadequate Sleep | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Inborn Errors of Metabolism | 0 | | 1985 | 2010 | 27.5 | low | 0 | 1 | 2 | 1 | 0 | 0 |
| Infant Malnutrition | 0 | | 1986 | 2013 | 24.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Infant, Newborn, Diseases | 0 | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Infant, Premature, Diseases | 0 | | 2001 | 2016 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Infant, Small for Gestational Age | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Infantile Respiratory Distress Syndrome | 0 | | 2000 | 2001 | 23.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Infection | 0 | | 1992 | 2020 | 18.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Infection, Postoperative Wound | 0 | | 1983 | 1989 | 38.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Infections | 0 | | 1992 | 2020 | 18.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Infections, Coronavirus | 0 | | 2020 | 2023 | 2.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Infections, Helicobacter | 0 | | 2001 | 2022 | 13.4 | low | 0 | 0 | 0 | 3 | 1 | 1 |
| Infections, Listeria | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Infections, Orthomyxoviridae | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Infections, Paramyxoviridae | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Infections, Parvoviridae | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Infections, Plasmodium | 0 | | 1988 | 2002 | 28.2 | low | 0 | 1 | 3 | 1 | 0 | 0 |
| Infections, Pneumococcal | 0 | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Infections, Pseudomonas | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Infections, Respiratory | 0 | | 1994 | 2010 | 22.0 | low | 1 | 0 | 1 | 1 | 0 | 0 |
| Infections, Spirochaetales | 0 | | 2001 | 2002 | 22.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Infections, Staphylococcal | 0 | | 1992 | 2023 | 10.8 | low | 0 | 0 | 1 | 0 | 3 | 1 |
| Infections, Staphylococcal Skin | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Infectious Diseases | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Infertility | 0 | | 1998 | 2010 | 21.0 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| Infertility, Female | 0 | | 1988 | 2018 | 21.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Infertility, Male | 0 | | 1994 | 2006 | 24.0 | low | 1 | 0 | 1 | 1 | 0 | 0 |
| Inflammation | 0 | | 1963 | 2023 | 10.8 | low | 11 | 1 | 7 | 26 | 73 | 19 |
| Inflammatory Bowel Diseases | 0 | | 1992 | 2023 | 16.8 | low | 1 | 0 | 1 | 3 | 1 | 1 |
| Injuries | 0 | | 1951 | 1995 | 44.4 | low | 0 | 4 | 1 | 0 | 0 | 0 |
| Injuries, Multiple | 0 | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Injuries, Radiation | 0 | | 1963 | 1964 | 60.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Injury, Ischemia-Reperfusion | 0 | | 1994 | 2023 | 21.2 | low | 0 | 0 | 6 | 0 | 1 | 1 |
| Injury, Myocardial Reperfusion | 0 | | 1993 | 2019 | 17.4 | low | 0 | 0 | 2 | 1 | 2 | 0 |
| Innate Inflammatory Response | 0 | | 1963 | 2023 | 10.8 | low | 11 | 1 | 7 | 26 | 73 | 19 |
| Insulin Resistance | 0 | | 1987 | 2023 | 13.8 | low | 4 | 1 | 3 | 19 | 25 | 4 |
| Insulin Sensitivity | 0 | | 1987 | 2023 | 13.8 | low | 4 | 1 | 3 | 19 | 25 | 4 |
| Insulinoma | 0 | | 2002 | 2019 | 16.8 | low | 0 | 0 | 0 | 5 | 1 | 0 |
| Intellectual Disability | 0 | | 2001 | 2023 | 12.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Intertrochanteric Fractures | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Intestinal Diseases | 0 | | 2000 | 2019 | 14.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Intestinal Neoplasms | 0 | | 2000 | 2004 | 22.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Intestinal Polyps | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Intraocular Pressure | 0 | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Invasiveness, Neoplasm | 0 | | 1994 | 2019 | 18.8 | low | 0 | 0 | 8 | 5 | 6 | 0 |
| Iridocyclitis | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Iron Overload | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Ischemia | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Ischemic Stroke | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Itching | 0 | | 1963 | 2019 | 20.3 | low | 2 | 1 | 1 | 1 | 4 | 0 |
| Jaundice, Neonatal | 0 | | 1994 | 1994 | 30.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| Joint Pain | 0 | | 2006 | 2006 | 18.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Kahler Disease | 0 | | 1997 | 2021 | 15.0 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| Keloid | 0 | | 1997 | 2000 | 25.5 | low | 0 | 0 | 4 | 0 | 0 | 0 |
| Keratoconjunctivitis Sicca | 0 | | 2003 | 2003 | 21.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Kidney Calculi | 0 | | 1963 | 2000 | 42.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Kidney Diseases | 0 | | 1988 | 2013 | 24.8 | low | 0 | 1 | 2 | 0 | 2 | 0 |
| Kidney Diseases, Cystic | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Kidney Failure | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Kidney Failure, Chronic | 0 | | 1983 | 2005 | 29.4 | low | 0 | 3 | 3 | 2 | 0 | 0 |
| Kidney Neoplasms | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Kidney Stones | 0 | | 1963 | 2000 | 42.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Kidney, Polycystic | 0 | | 2003 | 2007 | 19.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Koch's Disease | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Kwashiorkor | 0 | | 1986 | 1999 | 30.7 | low | 0 | 1 | 2 | 0 | 0 | 0 |
| Lactose Intolerance | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Laryngeal Neoplasms | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Lassitude | 0 | | 2014 | 2014 | 10.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| Leanness | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Learning Disabilities | 0 | | 1984 | 2006 | 29.0 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Left Ventricular Hypertrophy | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Leg Dermatoses | 0 | | 2017 | 2017 | 7.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| Leiomyosarcoma | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Leiomyosarcoma, Epithelioid | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Leishmania Infection | 0 | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Leishmaniasis | 0 | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Leishmaniasis, American | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Leishmaniasis, Cutaneous | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Leishmaniasis, Visceral | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Leprosy | 0 | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Leptospirosis | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Leucocythaemia | 0 | | 1985 | 2009 | 24.9 | low | 0 | 1 | 2 | 4 | 0 | 0 |
| Leukemia | 0 | | 1985 | 2009 | 24.9 | low | 0 | 1 | 2 | 4 | 0 | 0 |
| Leukemia, Acute Monocytic | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Leukemia, Basophilic, Acute | 0 | | 1992 | 1998 | 29.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Leukemia, Erythroblastic, Acute | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Leukemia, Lymphocytic | 0 | | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Leukemia, Lymphocytic, T Cell | 0 | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Leukemia, Lymphoid | 0 | | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Leukemia, Monocytic, Acute | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Leukemia, Myeloid, Acute | 0 | | 2013 | 2023 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Leukemia, Promyelocytic, Acute | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Leukemia, T-Cell | 0 | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Leukocytopenia | 0 | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Leukopenia | 0 | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Libman-Sacks Disease | 0 | | 2000 | 2003 | 22.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Lichen Planus, Oral | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Lipid Metabolism Disorders | 0 | | 1962 | 2022 | 17.0 | low | 0 | 1 | 0 | 0 | 0 | 3 |
| Lipid Metabolism, Inborn Error | 0 | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Lipidoses | 0 | | 1959 | 1985 | 56.5 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| Liver Cirrhosis | 0 | | 1959 | 2023 | 36.0 | low | 1 | 5 | 3 | 1 | 0 | 1 |
| Liver Cirrhosis, Alcoholic | 0 | | 1986 | 1995 | 33.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Liver Cirrhosis, Biliary | 0 | | 1959 | 1959 | 65.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Liver Diseases | 0 | | 1954 | 2020 | 33.8 | low | 0 | 7 | 2 | 2 | 5 | 0 |
| Liver Diseases, Alcoholic | 0 | | 1986 | 2015 | 25.8 | low | 0 | 2 | 2 | 3 | 1 | 0 |
| Liver Dysfunction | 0 | | 1954 | 2020 | 33.8 | low | 0 | 7 | 2 | 2 | 5 | 0 |
| Liver Failure | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Liver Neoplasms | 0 | | 1984 | 2022 | 17.6 | low | 1 | 2 | 9 | 12 | 10 | 4 |
| Liver Steatosis | 0 | | 1963 | 2020 | 24.7 | low | 1 | 7 | 2 | 12 | 8 | 0 |
| Local Neoplasm Recurrence | 0 | | 2008 | 2021 | 10.5 | low | 1 | 0 | 0 | 2 | 1 | 1 |
| Luft Disease | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Lung Adenocarcinoma | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Lung Diseases | 0 | | 1963 | 1963 | 61.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Lung Diseases, Obstructive | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Lung Injury, Acute | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Lung Neoplasms | 0 | | 1987 | 2023 | 22.2 | low | 0 | 4 | 10 | 6 | 3 | 3 |
| Lupus Erythematosus, Systemic | 0 | | 2000 | 2003 | 22.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Lymph Node Metastasis | 0 | | 1997 | 2001 | 25.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Lymphocytopenia | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Lymphoma | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Lymphoma, Non-Hodgkin | 0 | | 2006 | 2013 | 14.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Lymphopenia | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Macular Degeneration | 0 | | 2001 | 2021 | 14.7 | low | 0 | 0 | 0 | 4 | 1 | 1 |
| Magnesium Deficiency | 0 | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Malabsorption Syndromes | 0 | | 1982 | 1999 | 32.8 | low | 1 | 2 | 2 | 0 | 0 | 0 |
| Malaria | 0 | | 1988 | 2002 | 28.2 | low | 0 | 1 | 3 | 1 | 0 | 0 |
| Malaria, Falciparum | 0 | | 1994 | 1999 | 27.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Malassezia furfur Infection | 0 | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Malignant Melanoma | 0 | | 1987 | 2018 | 19.7 | low | 0 | 1 | 1 | 5 | 2 | 0 |
| Malnourishment | 0 | | 2011 | 2022 | 9.3 | low | 1 | 0 | 0 | 0 | 2 | 1 |
| Malnutrition | 0 | | 2011 | 2022 | 9.3 | low | 1 | 0 | 0 | 0 | 2 | 1 |
| Marasmus | 0 | | 1981 | 2022 | 25.5 | low | 1 | 3 | 4 | 1 | 1 | 1 |
| Mastitis, Bovine | 0 | | 2015 | 2019 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Maternal Obesity | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Measles | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Melanoma | 0 | | 1987 | 2018 | 19.7 | low | 0 | 1 | 1 | 5 | 2 | 0 |
| Melanosis | 0 | | 2002 | 2012 | 17.0 | low | 1 | 0 | 0 | 1 | 1 | 0 |
| Memory Disorders | 0 | | 1984 | 2017 | 23.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Meningeal Neoplasms | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Meningioma | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Menopause | 0 | | 1997 | 2016 | 17.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Metabolic Acidosis | 0 | | 1964 | 2003 | 40.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Metabolic Diseases | 0 | | 1993 | 2022 | 10.5 | low | 0 | 0 | 1 | 0 | 2 | 1 |
| Metabolic Skin Diseases | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Metabolic Syndrome | 0 | | 2002 | 2022 | 10.9 | low | 3 | 0 | 0 | 8 | 11 | 2 |
| Metabolically Benign Obesity | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Metabolism, Inborn Errors | 0 | | 1985 | 2010 | 27.5 | low | 0 | 1 | 2 | 1 | 0 | 0 |
| Metaplasia | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Metastase | 0 | | 1987 | 2018 | 24.5 | low | 0 | 4 | 10 | 7 | 3 | 0 |
| Migraine Disorders | 0 | | 1983 | 2018 | 15.0 | low | 1 | 1 | 0 | 0 | 3 | 0 |
| Mitochondrial Diseases | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Mitochondrial Myopathies | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Mood Disorders | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Morbid Obesity | 0 | | 2021 | 2021 | 3.0 | low | 1 | 0 | 0 | 0 | 0 | 1 |
| Mouth Neoplasms | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| MS (Multiple Sclerosis) | 0 | | 1965 | 1991 | 39.2 | low | 2 | 15 | 2 | 0 | 0 | 0 |
| Mucopolysaccharidosis I | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Mucositis | 0 | | 2013 | 2022 | 6.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Multiple Myeloma | 0 | | 1997 | 2021 | 15.0 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| Multiple Sclerosis | 0 | | 1965 | 1991 | 39.2 | low | 2 | 15 | 2 | 0 | 0 | 0 |
| Muscle Contraction | 0 | | 1982 | 2016 | 24.7 | low | 2 | 4 | 2 | 2 | 4 | 0 |
| Muscle Disorders | 0 | | 1981 | 1985 | 41.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Muscle Relaxation | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Muscular Atrophy | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Muscular Diseases | 0 | | 1981 | 1985 | 41.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Muscular Dystrophies | 0 | | 1964 | 1987 | 54.0 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| Muscular Dystrophy | 0 | | 1964 | 1987 | 54.0 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| Muscular Dystrophy, Animal | 0 | | 1991 | 1993 | 32.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Muscular Dystrophy, Duchenne | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Mycosis Fungoides | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Myocardial Infarction | 0 | | 1963 | 2022 | 25.7 | low | 3 | 10 | 3 | 8 | 5 | 3 |
| Myocardial Ischemia | 0 | | 1993 | 2019 | 19.0 | low | 0 | 0 | 3 | 1 | 3 | 0 |
| Nasal Catarrh | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Nasal Polyps | 0 | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Neck Pain | 0 | | 2016 | 2016 | 8.0 | low | 1 | 0 | 0 | 0 | 1 | 0 |
| Necrosis | 0 | | 1963 | 2008 | 28.8 | low | 0 | 2 | 2 | 5 | 0 | 0 |
| Necrotizing Enterocolitis | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Neoplasm Metastasis | 0 | | 1987 | 2018 | 24.5 | low | 0 | 4 | 10 | 7 | 3 | 0 |
| Neoplasms | 1 | | 1955 | 2022 | 20.9 | low | 0 | 7 | 13 | 24 | 21 | 2 |
| Nephritis | 0 | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Nephrocalcinosis | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Nerve Degeneration | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Nervous System Diseases | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Nervous System Disorders | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Neuritis | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Neuroblastoma | 0 | | 1984 | 2023 | 24.7 | low | 0 | 5 | 5 | 0 | 3 | 2 |
| Neurodegenerative Diseases | 0 | | 2011 | 2022 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Neuromyelitis Optica | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Non-alcoholic Fatty Liver Disease | 0 | | 2010 | 2023 | 5.4 | low | 1 | 0 | 0 | 1 | 6 | 6 |
| Non-communicable Chronic Diseases | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Nutrition Disorders | 0 | | 1965 | 2003 | 32.8 | low | 0 | 3 | 0 | 3 | 0 | 0 |
| Nutritional Disorders | 0 | | 1965 | 2003 | 32.8 | low | 0 | 3 | 0 | 3 | 0 | 0 |
| Obesity | 1 | | 1964 | 2023 | 12.9 | low | 13 | 5 | 8 | 25 | 63 | 14 |
| Obesity, Morbid | 0 | | 2021 | 2021 | 3.0 | low | 1 | 0 | 0 | 0 | 0 | 1 |
| Obstructive Lung Diseases | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Odontalgia | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Onchocerciasis | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Ornithine Carbamoyltransferase Deficiency Disease | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Oropharyngeal Neoplasms | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Orthomyxoviridae Infections | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Osteoarthritis | 0 | | 2008 | 2019 | 10.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Osteoporosis | 0 | | 2005 | 2020 | 11.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Otitis Externa | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Ovarian Neoplasms | 0 | | 1963 | 2022 | 18.7 | low | 0 | 1 | 1 | 0 | 2 | 2 |
| Overweight | 0 | | 2008 | 2022 | 7.7 | low | 4 | 0 | 0 | 1 | 10 | 2 |
| Pain | 0 | | 1985 | 2022 | 14.8 | low | 0 | 2 | 1 | 5 | 8 | 2 |
| Pain, Chronic | 0 | | 2016 | 2022 | 5.0 | low | 1 | 0 | 0 | 0 | 1 | 1 |
| Palmoplantaris Pustulosis | 0 | | 1952 | 2022 | 23.1 | low | 2 | 3 | 1 | 1 | 3 | 2 |
| Pancreatic Insufficiency | 0 | | 1985 | 2016 | 26.4 | low | 1 | 3 | 0 | 0 | 2 | 0 |
| Pancreatic Neoplasms | 0 | | 1985 | 2008 | 24.9 | low | 1 | 1 | 7 | 7 | 0 | 0 |
| Pancreatitis | 0 | | 1986 | 2019 | 26.1 | low | 2 | 2 | 5 | 0 | 2 | 0 |
| Papilloma | 0 | | 1991 | 2000 | 28.3 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| Papilloma, Squamous Cell | 0 | | 1991 | 2000 | 28.3 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| Papillomavirus Infections | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Paramyxoviridae Infections | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Parasitemia | 0 | | 1995 | 2020 | 16.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Parkinson Disease | 0 | | 2011 | 2022 | 6.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Parkinsonian Disorders | 0 | | 2011 | 2018 | 9.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Peanut Hypersensitivity | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Pellagra | 0 | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Pelvic Pain | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Peptic Ulcer | 0 | | 1993 | 1994 | 30.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Pericementitis | 0 | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Periodontitis | 0 | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Peripheral Arterial Disease | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Peripheral Arterial Diseases | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Peripheral Nerve Diseases | 0 | | 2007 | 2020 | 12.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Peripheral Nervous System Diseases | 0 | | 2007 | 2020 | 12.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Peripheral Vascular Diseases | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Peritoneal Carcinomatosis | 0 | | 1995 | 2013 | 19.3 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| Peritoneal Neoplasms | 0 | | 1995 | 2013 | 19.3 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| Pervasive Child Development Disorders | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Petechiae | 0 | | 1957 | 1957 | 67.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Phenylketonurias | 0 | | 1995 | 1998 | 27.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Pigmentary Retinopathy | 0 | | 1963 | 1964 | 60.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Plasma Cell Tumor | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Plasmacytoma | 0 | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Plasmodium falciparum Malaria | 0 | | 1994 | 1999 | 27.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Pleural Effusion | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Pleurisy | 0 | | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Pneumococcal Infections | 0 | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Pneumonia | 0 | | 1985 | 2006 | 25.3 | low | 0 | 1 | 0 | 2 | 0 | 0 |
| Pneumonia, Viral | 0 | | 2003 | 2020 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Poisoning | 0 | | 1989 | 1989 | 35.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Poliomyelitis | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Polyarthritis | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Polycystic Kidney Diseases | 0 | | 2003 | 2007 | 19.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Polycystic Ovarian Syndrome | 0 | | 2011 | 2017 | 10.0 | low | 1 | 0 | 0 | 0 | 2 | 0 |
| Polycystic Ovary Syndrome | 0 | | 2011 | 2017 | 10.0 | low | 1 | 0 | 0 | 0 | 2 | 0 |
| Polyploid | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Polyuria | 0 | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Postoperative Complications | 0 | | 1986 | 1994 | 34.0 | low | 1 | 1 | 1 | 0 | 0 | 0 |
| Poultry Diseases | 0 | | 1960 | 2009 | 39.9 | low | 0 | 3 | 2 | 2 | 0 | 0 |
| Pre-Eclampsia | 0 | | 1985 | 2018 | 20.2 | low | 1 | 2 | 3 | 5 | 4 | 0 |
| Precancerous Conditions | 0 | | 1987 | 2017 | 26.6 | low | 0 | 3 | 4 | 3 | 1 | 0 |
| Precursor Cell Lymphoblastic Leukemia-Lymphoma | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Pregnancy | 0 | | 1955 | 2023 | 21.9 | low | 15 | 39 | 59 | 56 | 49 | 16 |
| Pregnancy in Diabetes | 0 | | 1985 | 2002 | 30.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Premature Birth | 0 | | 2005 | 2018 | 10.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Premenstrual Syndrome | 0 | | 1984 | 1990 | 36.7 | low | 0 | 2 | 1 | 0 | 0 | 0 |
| Premenstrual Tension | 0 | | 1984 | 1990 | 36.7 | low | 0 | 2 | 1 | 0 | 0 | 0 |
| Preterm Birth | 0 | | 2005 | 2018 | 10.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Prostatic Hyperplasia | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Prostatic Neoplasms | 0 | | 1989 | 2020 | 20.4 | low | 1 | 1 | 11 | 18 | 7 | 0 |
| Protein-Energy Malnutrition | 0 | | 1981 | 2022 | 25.5 | low | 1 | 3 | 4 | 1 | 1 | 1 |
| Proteinuria | 0 | | 1985 | 2003 | 31.1 | low | 0 | 4 | 1 | 2 | 0 | 0 |
| Pruritus | 0 | | 1963 | 2019 | 20.3 | low | 2 | 1 | 1 | 1 | 4 | 0 |
| Pseudomonas Infections | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Psoriasis | 0 | | 1952 | 2022 | 23.1 | low | 2 | 3 | 1 | 1 | 3 | 2 |
| Psychoses | 0 | | 2013 | 2018 | 8.5 | low | 1 | 0 | 0 | 0 | 4 | 0 |
| Psychotic Disorders | 0 | | 2013 | 2018 | 8.5 | low | 1 | 0 | 0 | 0 | 4 | 0 |
| Puerperal Disorders | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Pulmonary Arterial Remodeling | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Pulmonary Disease, Chronic Obstructive | 0 | | 2012 | 2021 | 7.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Pulmonary Fibrosis | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Pulmonary Hypertension | 0 | | 1996 | 2023 | 14.5 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| Purpura | 0 | | 1957 | 1957 | 67.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Pyruvate Dehydrogenase Complex Deficiency Disease | 0 | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Radiodermatitis | 0 | | 1964 | 2009 | 37.5 | low | 0 | 1 | 0 | 1 | 0 | 0 |
| Recrudescence | 0 | | 1983 | 2015 | 24.5 | low | 1 | 1 | 1 | 1 | 1 | 0 |
| Rectal Neoplasms | 0 | | 1999 | 2019 | 15.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Refeeding Syndrome | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Refractive Errors | 0 | | 2003 | 2003 | 21.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Renal Insufficiency | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Renal Insufficiency, Chronic | 0 | | 2014 | 2018 | 8.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Reperfusion Injury | 0 | | 1994 | 2023 | 21.2 | low | 0 | 0 | 6 | 0 | 1 | 1 |
| Reproductive Sterility | 0 | | 1998 | 2010 | 21.0 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| Respiratory Distress Syndrome | 0 | | 1994 | 2000 | 28.0 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| Respiratory Distress Syndrome, Newborn | 0 | | 2000 | 2001 | 23.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Respiratory Insufficiency | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Respiratory Tract Diseases | 0 | | 1963 | 1963 | 61.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Respiratory Tract Infections | 0 | | 1994 | 2010 | 22.0 | low | 1 | 0 | 1 | 1 | 0 | 0 |
| Reticulum Cell-Like Sarcoma, Yoshida | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Retinal Degeneration | 0 | | 1986 | 1996 | 34.0 | low | 0 | 2 | 1 | 0 | 0 | 0 |
| Retinal Diseases | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Retinitis Pigmentosa | 0 | | 1963 | 1964 | 60.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Retinoblastoma | 0 | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Rheumatoid Arthritis | 0 | | 1985 | 2023 | 23.0 | low | 1 | 2 | 3 | 0 | 1 | 1 |
| Rhinitis | 0 | | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Rhinitis, Allergic, Nonseasonal | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Rhinitis, Allergic, Perennial | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Rhinitis, Allergic, Seasonal | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Rodent Diseases | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Rosacea | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Rubeola | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Sarcoma | 0 | | 1962 | 1962 | 62.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Sarcoma, Epithelioid | 0 | | 1962 | 1962 | 62.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Schistosoma mansoni Infection | 0 | | 1994 | 2010 | 22.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Schistosomiasis | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Schistosomiasis mansoni | 0 | | 1994 | 2010 | 22.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Schizophrenia | 0 | | 1981 | 2018 | 21.2 | low | 0 | 2 | 2 | 0 | 4 | 0 |
| Seizures | 0 | | 1998 | 2009 | 20.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Sensitivity and Specificity | 0 | | 1997 | 2021 | 18.6 | low | 1 | 0 | 1 | 19 | 1 | 1 |
| Sepsis | 0 | | 1983 | 2022 | 19.7 | low | 0 | 1 | 0 | 1 | 0 | 1 |
| Severe Acute Malnutrition | 0 | | 2022 | 2023 | 1.7 | low | 2 | 0 | 0 | 0 | 0 | 3 |
| Shock, Septic | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Short Bowel Syndrome | 0 | | 1999 | 2009 | 21.0 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| Sicca Syndrome | 0 | | 2005 | 2005 | 19.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Sjogren-Larsson Syndrome | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Sjogren's Syndrome | 0 | | 2005 | 2005 | 19.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Skin Aging | 0 | | 2007 | 2020 | 7.6 | low | 1 | 0 | 0 | 1 | 4 | 0 |
| Skin Diseases | 0 | | 1993 | 2020 | 14.8 | low | 1 | 0 | 2 | 1 | 3 | 0 |
| Skin Neoplasms | 0 | | 1987 | 2009 | 24.2 | low | 0 | 2 | 8 | 7 | 0 | 0 |
| Sleep Apnea, Obstructive | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Sleep Disorders, Circadian Rhythm | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Spider Veins | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ST Elevated Myocardial Infarction | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ST Elevation Myocardial Infarction | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Staphylococcal Infections | 0 | | 1992 | 2023 | 10.8 | low | 0 | 0 | 1 | 0 | 3 | 1 |
| Staphylococcal Skin Infections | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Starvation | 0 | | 1965 | 2019 | 30.2 | low | 0 | 2 | 0 | 2 | 1 | 0 |
| Stasis Ulcer | 0 | | 2008 | 2008 | 16.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Steatorrhea | 0 | | 1964 | 1964 | 60.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Sterility, Female | 0 | | 1988 | 2018 | 21.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Sterility, Male | 0 | | 1994 | 2006 | 24.0 | low | 1 | 0 | 1 | 1 | 0 | 0 |
| Stillbirth | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Stomach Neoplasms | 0 | | 1986 | 2013 | 20.1 | low | 0 | 1 | 2 | 10 | 3 | 0 |
| Stomach Ulcer | 0 | | 1988 | 2022 | 18.8 | low | 0 | 1 | 1 | 1 | 1 | 1 |
| Streptococcal Infections | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Stroke | 0 | | 2003 | 2020 | 9.3 | low | 0 | 0 | 0 | 2 | 10 | 0 |
| Stunted Growth | 0 | | 1996 | 2018 | 17.8 | low | 1 | 0 | 2 | 1 | 2 | 0 |
| Subarachnoid Hemorrhage | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Substance Withdrawal Syndrome | 0 | | 1985 | 1987 | 38.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| Sunburn | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Swine Diseases | 0 | | 1965 | 2002 | 31.8 | low | 0 | 1 | 0 | 3 | 0 | 0 |
| Symptom Cluster | 0 | | 1954 | 2016 | 38.1 | low | 0 | 4 | 2 | 1 | 1 | 0 |
| Syndrome | 0 | | 1954 | 2016 | 38.1 | low | 0 | 4 | 2 | 1 | 1 | 0 |
| Syphilis | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Telangiectasis | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Tendinitis | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Tendinopathy | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Tetralogy of Fallot | 0 | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Thiamine Deficiency | 0 | | 1965 | 1965 | 59.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Thrombosis | 0 | | 1964 | 2022 | 28.8 | low | 0 | 3 | 8 | 1 | 1 | 1 |
| Thymoma | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Thymus Neoplasms | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Thyroid Neoplasms | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Tinea Versicolor | 0 | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Toothache | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Tremor | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Triple Negative Breast Neoplasms | 0 | | 2018 | 2020 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Trypanosomiasis, African | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Tuberculosis | 0 | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Uremia | 0 | | 1992 | 2021 | 17.0 | low | 0 | 0 | 1 | 1 | 0 | 1 |
| Urinary Bladder Neoplasms | 0 | | 1995 | 2004 | 23.2 | low | 0 | 0 | 1 | 3 | 0 | 0 |
| Urinary Bladder, Overactive | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Urinary Tract Infections | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Urticaria | 0 | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Uterine Cervical Neoplasms | 0 | | 1987 | 1998 | 33.8 | low | 0 | 3 | 1 | 0 | 0 | 0 |
| Uterine Neoplasms | 0 | | 1985 | 2000 | 31.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| Varicocele | 0 | | 1994 | 1994 | 30.0 | low | 1 | 0 | 1 | 0 | 0 | 0 |
| Varicose Ulcer | 0 | | 2008 | 2008 | 16.0 | low | 1 | 0 | 0 | 1 | 0 | 0 |
| Vascular Diseases | 0 | | 1991 | 1991 | 33.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Vasospasm, Intracranial | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Ventricular Fibrillation | 0 | | 2000 | 2022 | 13.0 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| Viral Diseases | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Virus Diseases | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Vitamin A Deficiency | 0 | | 1995 | 2000 | 26.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Vitamin D Deficiency | 0 | | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Wasting Disease | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Weight Gain | 0 | | 1960 | 2023 | 21.6 | low | 5 | 1 | 24 | 26 | 14 | 1 |
| Weight Loss | 0 | | 1999 | 2013 | 20.8 | low | 1 | 0 | 3 | 7 | 1 | 0 |
| Weight Reduction | 0 | | 1999 | 2013 | 20.8 | low | 1 | 0 | 3 | 7 | 1 | 0 |
| Wounds and Injuries | 0 | | 1951 | 1995 | 44.4 | low | 0 | 4 | 1 | 0 | 0 | 0 |
| Xeroderma | 0 | | 1986 | 2022 | 14.0 | low | 0 | 1 | 0 | 0 | 0 | 2 |
| Zika Virus Infection | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Zoonoses | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
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7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD.The Journal of steroid biochemistry and molecular biology, , Volume: 169, 2017
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Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice.International journal of sports medicine, , Volume: 42, Issue:5, 2021
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Human RPE melanosomes protect from photosensitized and iron-mediated oxidation but become pro-oxidant in the presence of iron upon photodegradation.Investigative ophthalmology & visual science, , Volume: 49, Issue:7, 2008
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Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults.PloS one, , Oct-03, Volume: 2, Issue:10, 2007
Omega-6 and omega-3 fatty acids predict accelerated decline of peripheral nerve function in older persons.European journal of neurology, , Volume: 14, Issue:7, 2007
Linoleic acid derivative DCP-LA improves learning impairment in SAMP8.Neuroreport, , Jan-23, Volume: 17, Issue:1, 2006
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Synthetically prepared Aamadori-glycated phosphatidylethanolaminecan trigger lipid peroxidation via free radical reactions.FEBS letters, , Sep-08, Volume: 481, Issue:1, 2000
Gamma-linolenic acid provides additional protection against ventricular fibrillation in aged rats fed linoleic acid rich diets.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 62, Issue:2, 2000
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Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse.Aging (Milan, Italy), , Volume: 11, Issue:1, 1999
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Linoleic acid peroxidation--the dominant lipid peroxidation process in low density lipoprotein--and its relationship to chronic diseases.Chemistry and physics of lipids, , Volume: 95, Issue:2, 1998
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Evidence for age-related differences in the fatty acid composition of human adipose tissue, independent of diet.European journal of clinical nutrition, , Volume: 51, Issue:9, 1997
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Estimation of essential fatty acid requirements of common carp larvae using semi-purified artificial diets.Archiv fur Tierernahrung, , Volume: 49, Issue:1, 1996
Dietary linoleic acid increases and palmitic acid decreases hepatic LDL receptor protein and mRNA abundance in young pigs.Journal of lipid research, , Volume: 37, Issue:11, 1996
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Alpha-tocopherol and phospholipase A2 in liver and brain of chicks posthatching: the influence of dietary fat and vitamin E.Annals of nutrition & metabolism, , Volume: 39, Issue:5, 1995
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Age-related depletion of linoleic acid desaturation in liver microsomes from young spontaneously hypertensive rats.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 53, Issue:1, 1995
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Linoleic acid passage through the blood-brain barrier and a possible effect of age.Neurochemical research, , Volume: 19, Issue:2, 1994
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Linoleoyl-enriched triacylglycerol species increase in maternal liver during late pregnancy in the rat.Lipids, , Volume: 27, Issue:1, 1992
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Effects of a high-linoleate and a high-alpha-linolenate diet on the learning ability of aged rats. Evidence against an autoxidation-related lipid peroxide theory of aging.Journal of gerontology, , Volume: 46, Issue:1, 1991
Study on the lipid composition of aging Fischer-344 rat lymphoid cells: effect of long-term calorie restriction.Lipids, , Volume: 26, Issue:6, 1991
Gamma-linolenic acid dietary supplementation can reverse the aging influence on rat liver microsome delta 6-desaturase activity.Biochimica et biophysica acta, , May-08, Volume: 1083, Issue:2, 1991
Metabolic transformation of intracraneally injected [1-14C]linoleic and [1-14C]alpha-linolenic acids in malnourished developing rats.Lipids, , Volume: 26, Issue:11, 1991
Dietary restriction maintains linoleic and arachidonic acid levels in murine liver during aging.Aging (Milan, Italy), , Volume: 3, Issue:4, 1991
Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats.The American journal of physiology, , Volume: 259, Issue:1 Pt 1, 1990
Age-related changes in linoleate and alpha-linolenate desaturation by rat liver microsomes.Biochemical and biophysical research communications, , Aug-30, Volume: 163, Issue:1, 1989
Comparison of the increment in plasma eicosapentaenoate concentrations by fish oil intake between young and middle-aged volunteers.Journal of nutritional science and vitaminology, , Volume: 35, Issue:4, 1989
Linoleic acid-induced fatty acid changes in platelet and aorta of the rat: effect of age and cholesterol.Lipids, , Volume: 23, Issue:9, 1988
Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats.Annals of nutrition & metabolism, , Volume: 32, Issue:3, 1988
Fatty acids of plasma lipids, red cells and platelets in Alzheimer's disease and vascular dementia.Atherosclerosis, , Volume: 65, Issue:3, 1987
Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids.Annals of nutrition & metabolism, , Volume: 30, Issue:3, 1986
Linoleate content of epidermal acylglucosylceramide in newborn, growing and mature mice.Biochimica et biophysica acta, , May-21, Volume: 876, Issue:3, 1986
Effects of linoleic acid and gamma-linolenic acid intake on platelet functions in elderly people.Thrombosis research, , May-15, Volume: 42, Issue:4, 1986
Effect of age on the linoleate content of skin acylglucosylceramide in mice.Nutrition reviews, , Volume: 44, Issue:11, 1986
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Letter by Lucas Regarding Articles, "Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies" and "Circulating Omega-6 Polyunsaturated Fatty Acids and Total and Cause-Specific MortalityCirculation, , Jul-21, Volume: 132, Issue:3, 2015
Letter by Hoenselaar Regarding Article, "Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies".Circulation, , Jul-21, Volume: 132, Issue:3, 2015
Circulating omega-6 polyunsaturated fatty acids and total and cause-specific mortality: the Cardiovascular Health Study.Circulation, , Oct-07, Volume: 130, Issue:15, 2014
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Omega3 fatty acids effectively prevent coronary heart disease and other late-onset diseases--the excessive linoleic acid syndrome.World review of nutrition and dietetics, , Volume: 96, 2007
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High content of dietary linoleic acid does not reduce platelet reactivity in patients with hyperlipoproteinaemia.European journal of clinical investigation, , Volume: 16, Issue:1, 1986
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Hepatomegaly induced by trans-10,cis-12 conjugated linoleic acid in adult hamsters fed an atherogenic diet is not associated with steatosis.Journal of the American College of Nutrition, , Volume: 28, Issue:1, 2009
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Lack of promoting effects of alpha-linolenic, linoleic or palmitic acid on urinary bladder carcinogenesis in rats.Japanese journal of cancer research : Gann, , Volume: 86, Issue:6, 1995
Pseudo-acylceramide with linoleic acid produces selective recovery of diminished cutaneous barrier function in essential fatty acid-deficient rats and has an inhibitory effect on epidermal hyperplasia.The Journal of clinical investigation, , Volume: 94, Issue:1, 1994
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Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic airway disease in mice.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 38, Issue:1, 2008
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Association of omega-6 polyunsaturated fatty acids with blood pressure: A systematic review and meta-analysis of observational studies.Critical reviews in food science and nutrition, , Volume: 63, Issue:14, 2023
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Linoleic acid reduces vascular reactivity and improves the vascular dysfunction of the small mesentery in hypertension.The Journal of nutritional biochemistry, , Volume: 62, 2018
Deamidated lipocalin-2 induces endothelial dysfunction and hypertension in dietary obese mice.Journal of the American Heart Association, , Apr-10, Volume: 3, Issue:2, 2014
Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats.International journal of food sciences and nutrition, , Volume: 64, Issue:5, 2013
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Visceral fat thickness in overweight men correlates with alterations in serum fatty acid composition.Clinica chimica acta; international journal of clinical chemistry, , Volume: 398, Issue:1-2, 2008
Linoleate-rich high-fat diet decreases mortality in hypertensive heart failure rats compared with lard and low-fat diets.Hypertension (Dallas, Tex. : 1979), , Volume: 52, Issue:3, 2008
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Dietary linolenic acid is associated with a lower prevalence of hypertension in the NHLBI Family Heart Study.Hypertension (Dallas, Tex. : 1979), , Volume: 45, Issue:3, 2005
Arachidonic acid in adipose tissue is associated with nonfatal acute myocardial infarction in the central valley of Costa Rica.The Journal of nutrition, , Volume: 134, Issue:11, 2004
Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats.Biochemical and biophysical research communications, , Oct-15, Volume: 323, Issue:2, 2004
Virgin olive oil normalizes the altered triacylglycerol molecular species composition of adipose tissue in spontaneously hypertensive rats.Journal of agricultural and food chemistry, , Jun-30, Volume: 52, Issue:13, 2004
The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima fatty rats.Biochemical and biophysical research communications, , Jun-20, Volume: 306, Issue:1, 2003
Dietary fat and meat intake in relation to risk of type 2 diabetes in men.Diabetes care, , Volume: 25, Issue:3, 2002
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Bioactive substances in milk with properties decreasing risk of cardiovascular diseases.The British journal of nutrition, , Volume: 84 Suppl 1, 2000
A high sucrose, high linoleic acid diet potentiates hypertension in the Dahl salt sensitive rat.American journal of hypertension, , Volume: 12, Issue:2 Pt 1, 1999
Attenuation of experimental hypertension by dietary linoleic acid is model dependent.Journal of the American College of Nutrition, , Volume: 15, Issue:1, 1996
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Age-related depletion of linoleic acid desaturation in liver microsomes from young spontaneously hypertensive rats.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 53, Issue:1, 1995
trans isomers of oleic and linoleic acids in adipose tissue and sudden cardiac death.Lancet (London, England), , Feb-04, Volume: 345, Issue:8945, 1995
Age-related changes in linoleic acid bioconversion by isolated hepatocytes from spontaneously hypertensive and normotensive rats.Molecular and cellular biochemistry, , Dec-07, Volume: 141, Issue:1, 1994
Essential fatty acid metabolism in south Indians.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 50, Issue:5, 1994
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Effect of salt-loading and spontaneous hypertension on in vitro metabolism of [1-14C]linoleic and [2-14C]dihomo-gamma-linolenic acids.Biochemical medicine and metabolic biology, , Volume: 49, Issue:1, 1993
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Arachidonic acid does not share the antihypertensive properties of linoleic acid and fish oil omega-3 fatty acids in a model of angiotensin II-induced hypertension in the rat.Clinical and investigative medicine. Medecine clinique et experimentale, , Volume: 14, Issue:6, 1991
Effects of linoleic acid supplementation on blood pressure and kinetics of red cell sodium transport: the Piove di Sacco Study.Journal of hypertension. Supplement : official journal of the International Society of Hypertension, , Volume: 9, Issue:6, 1991
Dietary linoleic acid prevents the development of deoxycorticosterone acetate-salt hypertension.Hypertension (Dallas, Tex. : 1979), , Volume: 15, Issue:2 Suppl, 1990
Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension.Journal of human hypertension, , Volume: 4, Issue:3, 1990
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Acute and chronic effects of eicosapentaenoic acid (EPA) on the cardiovascular system.Research communications in chemical pathology and pharmacology, , Volume: 66, Issue:3, 1989
Effect of varying concentrations of linoleic acid on alpha-adrenoceptor responses in spontaneously hypertensive rats.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 33, Issue:2, 1988
Effect of linoleic and oleic acids on blood pressure, blood viscosity, and erythrocyte cation transport.Journal of the American College of Nutrition, , Volume: 6, Issue:2, 1987
Slow desaturation and elongation of linoleic and alpha-linolenic acids as a rationale of eicosapentaenoic acid-rich diet to lower blood pressure and serum lipids in normal, hypertensive and hyperlipemic subjects.Prostaglandins, leukotrienes, and medicine, , Volume: 24, Issue:2-3, 1986
Different changes of n-6 and n-3 fatty acids in adipose tissue from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with linolenic or eicosapentaenoic acids.Prostaglandins, leukotrienes, and medicine, , Volume: 24, Issue:2-3, 1986
Effects of dietary lipid composition on serum lipoproteins.Progress in clinical and biological research, , Volume: 188, 1985
The effect of dietary supplementation with linoleic and gammalinolenic acids on the pressor response to angiotensin II--a possible role in pregnancy-induced hypertension?British journal of clinical pharmacology, , Volume: 19, Issue:3, 1985
Decrease of arachidonic acid in phosphatidylcholine from renal medulla of SHR after feeding a linoleic and linolenic acid-rich diet.Biomedica biochimica acta, , Volume: 43, Issue:8-9, 1984
Attenuation of high blood pressure by primrose oil, linseed oil and sunflowerseed oil in spontaneously hypertensive rats.Biomedica biochimica acta, , Volume: 43, Issue:8-9, 1984
Alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of SHR during the onset of hypertension.Biomedica biochimica acta, , Volume: 43, Issue:8-9, 1984
[In vitro study of delta 6- and delta 5-desaturations of linoleic and dihomo-gamma-linolenic acids during the development of arterial hypertension as a function of age in spontaneously hypertensive rats (SHR) as compared to normotensive rats (WKY)].Comptes rendus des seances de la Societe de biologie et de ses filiales, , Volume: 178, Issue:4, 1984
Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats.Prostaglandins, , Volume: 27, Issue:3, 1984
Defective desaturation and elongation of n-6 and n-3 fatty acids in hypertensive patients.Prostaglandins, leukotrienes, and medicine, , Volume: 15, Issue:2, 1984
[Clinical aspects of typical changes in carbohydrate and lipid metabolism in essential hypertension].Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, , Jun-01, Volume: 37, Issue:11, 1982
Physiological effects of varying dietary linoleic acid in spontaneously hypertensive rats.Annals of nutrition & metabolism, , Volume: 26, Issue:4, 1982
Alterations in renal and aortic prostaglandin E and F formation correlate with blood pressure dietary linoleate deficiency.Archives internationales de pharmacodynamie et de therapie, , Volume: 259, Issue:1, 1982
Dietary linoleic acid and salt-induced hypertension.Canadian journal of physiology and pharmacology, , Volume: 59, Issue:8, 1981
[FAVORABLE ACTION OF INTRAVENOUS ESSENTIAL PHOSPHOLIPIDS ON RENAL FUNCTION STUDIED BY MEANS OF CLEARANCE TESTS].Rivista di patologia e clinica, , Volume: 18, 1963
STUDY ON REGRESSION OF ATHEROSCLEROSIS IN RABBITS.Nagoya journal of medical science, , Volume: 26, 1963
Impaired catecholamine inactivation. A prohypertensive stimulus after dietary linoleate deficiency in salt-loaded rats?Hypertension (Dallas, Tex. : 1979), , Volume: 5, Issue:6
Influence of renal prostaglandins and dietary linoleate on hypertension in Dahl S rats.Hypertension (Dallas, Tex. : 1979), , Volume: 4, Issue:3 Pt 2
Rationale of the diet-heart statement of the American Heart Association. Report of the AHA nutrition committee.Arteriosclerosis (Dallas, Tex.), , Volume: 2, Issue:2
Effect of hypothyroidism on the lipid composition and fluidity of rat colonic apical plasma membranes.Biochimica et biophysica acta, , Apr-07, Volume: 939, Issue:2, 1988
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Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: A targeted metabolomic approach.Prostaglandins & other lipid mediators, , Volume: 118-119
Impaired production of skin barrier lipid acylceramides and abnormal localization of PNPLA1 due to ichthyosis-causing mutations in PNPLA1.Journal of dermatological science, , Volume: 107, Issue:2, 2022
ω-O-Acylceramides but not ω-hydroxy ceramides are required for healthy lamellar phase architecture of skin barrier lipids.Journal of lipid research, , Volume: 63, Issue:6, 2022
Control of polyunsaturated acids in tissue lipids.Journal of the American College of Nutrition, , Volume: 5, Issue:2, 1986
Polyunsaturated fatty acids, inflammation, and immunity.Lipids, , Volume: 36, Issue:9, 2001
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[Vitamin F in therapy of allergic syndromes and liver diseases].Nederlands tijdschrift voor geneeskunde, , Jul-24, Volume: 98, Issue:30, 1954
The Effect of Olive Fruit Fly Molecules (Basel, Switzerland), , Dec-28, Volume: 26, Issue:1, 2020
Linoleic acid and the immune response.European journal of clinical nutrition, , Volume: 46, Issue:12, 1992
Metabolism of non-protein energy-substrates in septic rats receiving parenteral nutrition.International surgery, , Volume: 71, Issue:1
[The role of polyunsaturated fatty acids, especially linoleate, in the enhancement of resistance to bacterial infection].Shonika kiyo. Annales paediatrici Japonici, , Volume: 7
Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men.Clinical nutrition (Edinburgh, Scotland), , Volume: 29, Issue:1, 2010
Hyperlipidemia and reproductive failure in captive-reared alligators: vitamin E, vitamin A, plasma lipids, fatty acids, and steroid hormones.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, , Volume: 128, Issue:2, 2001
Fatty acid composition of fertilization-failed human oocytes.Human reproduction (Oxford, England), , Volume: 13, Issue:8, 1998
The association of eicosanoids and eicosanoid-related metabolites with pulmonary hypertension.The European respiratory journal, , Volume: 62, Issue:4, 2023
Changes in polyunsaturated fatty acids during treatment of malnourished children may be insufficient to reach required essential fatty acid levels - A randomised controlled trial.Clinical nutrition (Edinburgh, Scotland), , Volume: 42, Issue:9, 2023
A unique inflammation-related mechanism by which high-fat diets induce depression-like behaviors in mice.Journal of affective disorders, , 10-15, Volume: 339, 2023
Age-related changes in adipose tissue metabolomics and inflammation, cardiolipin metabolism, and ferroptosis markers in female aged rat model.Biochemical and biophysical research communications, , 09-03, Volume: 671, 2023
The effects of dietary linoleic acid on reducing serum cholesterol and atherosclerosis development are nullified by a high-cholesterol diet in male and female apoE-deficient mice.The British journal of nutrition, , 03-14, Volume: 129, Issue:5, 2023
Linoleic acid, an omega-6 fatty acid that reduces risk for cardiometabolic diseases: premise, promise and practical implications.Current opinion in clinical nutrition and metabolic care, , 05-01, Volume: 26, Issue:3, 2023
Dietary Fatty Acids and Inflammation: Focus on the n-6 Series.International journal of molecular sciences, , Feb-26, Volume: 24, Issue:5, 2023
A Comprehensive Analysis of Microflora and Metabolites in the Development of Ulcerative Colitis into Colorectal Cancer Based on the Lung-Gut Correlation Theory.Molecules (Basel, Switzerland), , Sep-08, Volume: 27, Issue:18, 2022
Nrf2 pathway in vegetable oil-induced inflammation of large yellow croaker (Larimichthys crocea).Fish & shellfish immunology, , Volume: 127, 2022
The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism.European journal of nutrition, , Volume: 61, Issue:7, 2022
Chronic exposure to traffic-related air pollution reduces lipid mediators of linoleic acid and soluble epoxide hydrolase in serum of female rats.Environmental toxicology and pharmacology, , Volume: 93, 2022
sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury.Proceedings of the National Academy of Sciences of the United States of America, , 03-29, Volume: 119, Issue:13, 2022
Oxidized linoleic acid metabolites maintain mechanical and thermal hypersensitivity during sub-chronic inflammatory pain.Biochemical pharmacology, , Volume: 198, 2022
PUFA, genotypes and risk for cardiovascular disease.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 176, 2022
Resveratrol ameliorates lipid accumulation and inflammation in human SZ95 sebocytes via the AMPK signaling pathways in vitro.Journal of dermatological science, , Volume: 103, Issue:3, 2021
Could Dietary Factors Reduce COVID-19 Mortality Rates? Moderating the Inflammatory State.Journal of alternative and complementary medicine (New York, N.Y.), , Volume: 27, Issue:2, 2021
Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice.International journal of sports medicine, , Volume: 42, Issue:5, 2021
The need for precision nutrition, genetic variation and resolution in Covid-19 patients.Molecular aspects of medicine, , Volume: 77, 2021
The FADS1 Genotype Modifies Metabolic Responses to the Linoleic Acid and Alpha-linolenic Acid Containing Plant Oils-Genotype Based Randomized Trial FADSDIET2.Molecular nutrition & food research, , Volume: 65, Issue:7, 2021
Proopiomelanocortin Processing in the Hypothalamus Is Directly Regulated by Saturated Fat: Implications for the Development of Obesity.Neuroendocrinology, , Volume: 110, Issue:1-2, 2020
Isotope-reinforced polyunsaturated fatty acids improve Parkinson's disease-like phenotype in rats overexpressing α-synuclein.Acta neuropathologica communications, , 12-11, Volume: 8, Issue:1, 2020
Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection.Frontiers in immunology, , Volume: 11, 2020
Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: a review of recent studies.The Journal of nutritional biochemistry, , Volume: 86, 2020
Abnormal n-6 fatty acid metabolism in cystic fibrosis contributes to pulmonary symptoms.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 160, 2020
Activation of the Farnesoid X Receptor (FXR) Suppresses Linoleic Acid-Induced Inflammation in the Large Yellow Croaker (Larimichthys crocea).The Journal of nutrition, , 09-01, Volume: 150, Issue:9, 2020
Vasculometabolic and Inflammatory Effects of Aldosterone in Obesity.The Journal of clinical endocrinology and metabolism, , 08-01, Volume: 105, Issue:8, 2020
Changes in fatty acids in plasma and association with the inflammatory response in dairy cows abomasally infused with essential fatty acids and conjugated linoleic acid during late and early lactation.Journal of dairy science, , Volume: 103, Issue:12, 2020
Interplay of Dietary Fatty Acids and Cholesterol Impacts Brain Mitochondria and Insulin Action.Nutrients, , May-23, Volume: 12, Issue:5, 2020
Spectrofluorometric Analysis of Autofluorescing Components of Crude Serum from a Rat Liver Model of Ischemia and Reperfusion.Molecules (Basel, Switzerland), , Mar-14, Volume: 25, Issue:6, 2020
Diets with low n-6:n-3 PUFA ratio protects rats from fructose-induced dyslipidemia and associated hepatic changes: Comparison between 18:3 n-3 and long-chain n-3 PUFA.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 155, 2020
PCTR1 ameliorates lipopolysaccharide-induced acute inflammation and multiple organ damage via regulation of linoleic acid metabolism by promoting FADS1/FASDS2/ELOV2 expression and reducing PLA2 expression.Laboratory investigation; a journal of technical methods and pathology, , Volume: 100, Issue:7, 2020
Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXO.Life science alliance, , Volume: 3, Issue:2, 2020
Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice.Endocrinology, , 02-01, Volume: 161, Issue:2, 2020
Lipolysis modulates the biosynthesis of inflammatory lipid mediators derived from linoleic acid in adipose tissue of periparturient dairy cows.Journal of dairy science, , Volume: 103, Issue:2, 2020
Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids.Nature communications, , 09-05, Volume: 10, Issue:1, 2019
Modification of gene expression in rat cardiomyocytes by linoleic and docosahexaenoic acids Canadian journal of physiology and pharmacology, , Volume: 97, Issue:4, 2019
Inflammatory response to dietary linoleic acid depends on FADS1 genotype.The American journal of clinical nutrition, , 01-01, Volume: 109, Issue:1, 2019
Protective effect of linoleic acid against inflammatory reactions by mast cell via caspase-1 cascade pathways.Journal of food biochemistry, , Volume: 43, Issue:8, 2019
The role of linoleic acid in asthma and inflammatory markers: a Mendelian randomization study.The American journal of clinical nutrition, , 09-01, Volume: 110, Issue:3, 2019
Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 135, 2018
Digital gene-expression profiling analysis of the fatty liver of Landes geese fed different supplemental oils.Gene, , Oct-05, Volume: 673, 2018
The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain.Biochimica et biophysica acta. Molecular and cell biology of lipids, , Volume: 1863, Issue:7, 2018
Omega-6 fatty acids and inflammation.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 132, 2018
Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice.The American journal of pathology, , Volume: 187, Issue:10, 2017
A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch.Science signaling, , Aug-22, Volume: 10, Issue:493, 2017
Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung.Thorax, , Volume: 72, Issue:1, 2017
Supplemental feeding of a gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, alleviates spontaneous atopic dermatitis and modulates intestinal microbiota in NC/nga mice.International journal of food sciences and nutrition, , Volume: 68, Issue:8, 2017
Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases.Nutrients, , Oct-25, Volume: 9, Issue:11, 2017
Neither linoleic acid nor arachidonic acid promote white adipose tissue inflammation in Fads2-/- mice fed low fat diets.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 126, 2017
Beyond the classic eicosanoids: Peripherally-acting oxygenated metabolites of polyunsaturated fatty acids mediate pain associated with tissue injury and inflammation.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 111, 2016
Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells.Biochemical and biophysical research communications, , Mar-18, Volume: 471, Issue:4, 2016
Whole-blood fatty acids and inflammation in European children: the IDEFICS Study.European journal of clinical nutrition, , Volume: 70, Issue:7, 2016
Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties.Diabetes, , Volume: 65, Issue:9, 2016
Pro-inflammatory chemokines CCL2, chemerin, IP-10 and RANTES in human serum during an oral lipid tolerance test.Cytokine, , Volume: 80, 2016
Hydroxyoctadecadienoic acids: Oxidised derivatives of linoleic acid and their role in inflammation associated with metabolic syndrome and cancer.European journal of pharmacology, , Aug-15, Volume: 785, 2016
Three-dimensional spheroid cell model of in vitro adipocyte inflammation.Tissue engineering. Part A, , Volume: 21, Issue:11-12, 2015
A High Linoleic Acid Diet does not Induce Inflammation in Mouse Liver or Adipose Tissue.Lipids, , Volume: 50, Issue:11, 2015
ω-6 (18:2) and ω-3 (18:3) fatty acids in reconstituted high-density lipoproteins show different functionality of anti-atherosclerotic properties and embryo toxicity.The Journal of nutritional biochemistry, , Volume: 26, Issue:12, 2015
Excessive dietary linoleic acid induces proinflammatory markers in rats.The Journal of nutritional biochemistry, , Volume: 26, Issue:12, 2015
Maternal supplementation with conjugated linoleic acid in the setting of diet-induced obesity normalises the inflammatory phenotype in mothers and reverses metabolic dysfunction and impaired insulin sensitivity in offspring.The Journal of nutritional biochemistry, , Volume: 26, Issue:12, 2015
Omega-3 PUFAs Lower the Propensity for Arachidonic Acid Cascade Overreactions.BioMed research international, , Volume: 2015, 2015
Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease.The American journal of pathology, , Volume: 185, Issue:1, 2015
Australia's nutrition transition 1961-2009: a focus on fats.The British journal of nutrition, , Aug-14, Volume: 114, Issue:3, 2015
Associations of erythrocyte membrane fatty acids with the concentrations of C-reactive protein, interleukin 1 receptor antagonist and adiponectin in 1373 men.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 91, Issue:4, 2014
Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans.The Journal of biological chemistry, , Aug-08, Volume: 289, Issue:32, 2014
Linoleate appears to protect against palmitate-induced inflammation in Huh7 cells.Lipids in health and disease, , May-13, Volume: 13, 2014
Serum fatty acid patterns, insulin sensitivity and the metabolic syndrome in individuals with chronic kidney disease.Journal of internal medicine, , Volume: 275, Issue:1, 2014
Lipid mediator profiles differ between lung compartments in asthmatic and healthy humans.The European respiratory journal, , Volume: 43, Issue:2, 2014
Dietary factors associated with subclinical inflammation among girls.European journal of clinical nutrition, , Volume: 67, Issue:12, 2013
The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells.Nutritional neuroscience, , Volume: 16, Issue:1, 2013
Oxidized linoleic acid metabolite-cytochrome P450 system (OLAM-CYP) is active in biopsy samples from patients with inflammatory dental pain.Pain, , Volume: 154, Issue:11, 2013
Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice.Journal of lipid research, , Volume: 54, Issue:4, 2013
Effects of conjugated linoleic acid on growth, non-specific immunity, antioxidant capacity, lipid deposition and related gene expression in juvenile large yellow croaker (Larmichthys crocea) fed soyabean oil-based diets.The British journal of nutrition, , Volume: 110, Issue:7, 2013
Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization.Clinical and experimental immunology, , Volume: 174, Issue:3, 2013
Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon (Salmo salar L.) and mice, and induces weight gain and inflammation in mice.The British journal of nutrition, , Apr-28, Volume: 109, Issue:8, 2013
n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis.The British journal of nutrition, , Nov-14, Volume: 110, Issue:9, 2013
Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases.Lipids in health and disease, , May-07, Volume: 12, 2013
Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins.The American journal of cardiology, , Dec-01, Volume: 112, Issue:11, 2013
Fat necrosis generates proinflammatory halogenated lipids during acute pancreatitis.Annals of surgery, , Volume: 257, Issue:5, 2013
Conjugated linoleic acid isomers may diminish human macrophages adhesion to endothelial surface.International journal of food sciences and nutrition, , Volume: 63, Issue:1, 2012
Obesity modifies the association between plasma phospholipid polyunsaturated fatty acids and markers of inflammation: the Multi-Ethnic Study of Atherosclerosis.International journal of obesity (2005), , Volume: 36, Issue:6, 2012
Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD.The Journal of nutritional biochemistry, , Volume: 23, Issue:7, 2012
The role of Rho/Rho-kinase pathway in the expression of ICAM-1 by linoleic acid in human aortic endothelial cells.Inflammation, , Volume: 35, Issue:3, 2012
A.S.P.E.N. position paper: Clinical role for alternative intravenous fat emulsions.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, , Volume: 27, Issue:2, 2012
Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation.Pain, , Volume: 153, Issue:10, 2012
Cytochrome P450 mediated linoleic acid metabolism in peripheral inflammatory nociception.Pain, , Volume: 153, Issue:10, 2012
Effect of dietary linoleic acid on markers of inflammation in healthy persons: a systematic review of randomized controlled trials.Journal of the Academy of Nutrition and Dietetics, , Volume: 112, Issue:7, 2012
The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain.Molecular pain, , Sep-24, Volume: 8, 2012
Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status.Obesity (Silver Spring, Md.), , Volume: 19, Issue:2, 2011
α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations.The British journal of nutrition, , Volume: 105, Issue:1, 2011
New Cholesterol Guidelines for Longevity (2010).World review of nutrition and dietetics, , Volume: 102, 2011
Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response.Bioorganic & medicinal chemistry, , Oct-01, Volume: 19, Issue:19, 2011
Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components.Mutation research, , Aug-07, Volume: 690, Issue:1-2, 2010
Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation.Free radical biology & medicine, , May-15, Volume: 48, Issue:10, 2010
Fatty acid supplements improve respiratory, inflammatory and nutritional parameters in adults with cystic fibrosis.Archivos de bronconeumologia, , Volume: 46, Issue:2, 2010
Linoleic acid supplementation results in increased arachidonic acid and eicosanoid production in CF airway cells and in cftr-/- transgenic mice.American journal of physiology. Lung cellular and molecular physiology, , Volume: 299, Issue:5, 2010
Evolutionary aspects of the dietary omega-6:omega-3 fatty acid ratio: medical implications.World review of nutrition and dietetics, , Volume: 100, 2009
In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation.The British journal of nutrition, , Volume: 102, Issue:4, 2009
Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men.Nutrition research (New York, N.Y.), , Volume: 29, Issue:6, 2009
Reduced ex vivo interleukin-6 production by dietary fish oil is not modified by linoleic acid intake in healthy men.The Journal of nutrition, , Volume: 139, Issue:7, 2009
Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells.Chemico-biological interactions, , Mar-10, Volume: 172, Issue:1, 2008
Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms.Atherosclerosis, , Volume: 199, Issue:2, 2008
FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease.The American journal of clinical nutrition, , Volume: 88, Issue:4, 2008
The role of dietary n-6 fatty acids in the prevention of cardiovascular disease.Journal of cardiovascular medicine (Hagerstown, Md.), , Volume: 8 Suppl 1, 2007
Mechanisms by which dietary fats affect coronary heart disease mortality.World review of nutrition and dietetics, , Volume: 96, 2007
Decreasing linoleic acid with constant alpha-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men.The Journal of nutrition, , Volume: 137, Issue:4, 2007
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Linoleic acid, an omega-6 fatty acid that reduces risk for cardiometabolic diseases: premise, promise and practical implications.Current opinion in clinical nutrition and metabolic care, , 05-01, Volume: 26, Issue:3, 2023
Association between polyunsaturated fatty acids intake and insulin resistance in Brazilian adolescents (ERICA Study).Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 111, 2023
Title: Involvement of unsaturated fatty acid biosynthesis in CRC progression based on in vitro and in silico studies.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 153, 2022
Linoleic acid and the regulation of glucose homeostasis: A review of the evidence.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 175, 2021
Interplay of Dietary Fatty Acids and Cholesterol Impacts Brain Mitochondria and Insulin Action.Nutrients, , May-23, Volume: 12, Issue:5, 2020
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Maternal supplementation with conjugated linoleic acid in the setting of diet-induced obesity normalises the inflammatory phenotype in mothers and reverses metabolic dysfunction and impaired insulin sensitivity in offspring.The Journal of nutritional biochemistry, , Volume: 26, Issue:12, 2015
Serum fatty acid patterns, insulin sensitivity and the metabolic syndrome in individuals with chronic kidney disease.Journal of internal medicine, , Volume: 275, Issue:1, 2014
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trans-10,cis-12 conjugated linoleic acid prevents adiposity but not insulin resistance induced by an atherogenic diet in hamsters.The Journal of nutritional biochemistry, , Volume: 17, Issue:2, 2006
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[Need to change the direction of cholesterol-related medication--a problem of great urgency].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 125, Issue:11, 2005
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Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice.Endocrinology, , 02-01, Volume: 161, Issue:2, 2020
Decreasing the Ratio of Dietary Linoleic to α-Linolenic Acid from 10 to 4 by Changing Only the Former Does Not Prevent Adiposity or Bone Deterioration in Obese Mice.The Journal of nutrition, , 06-01, Volume: 150, Issue:6, 2020
Ethanolamides of essential α-linolenic and linoleic fatty acids suppress short-term food intake in rats.Food & function, , Apr-30, Volume: 11, Issue:4, 2020
Vasculometabolic and Inflammatory Effects of Aldosterone in Obesity.The Journal of clinical endocrinology and metabolism, , 08-01, Volume: 105, Issue:8, 2020
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Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection.Frontiers in immunology, , Volume: 11, 2020
Proopiomelanocortin Processing in the Hypothalamus Is Directly Regulated by Saturated Fat: Implications for the Development of Obesity.Neuroendocrinology, , Volume: 110, Issue:1-2, 2020
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Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXO.Life science alliance, , Volume: 3, Issue:2, 2020
Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids.Nature communications, , 09-05, Volume: 10, Issue:1, 2019
Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota?Antioxidants & redox signaling, , 01-10, Volume: 30, Issue:2, 2019
American Ginseng and Asian Ginseng Intervention in Diet-Induced Obese Mice: Metabolomics Reveals Distinct Metabolic Profiles.The American journal of Chinese medicine, , Volume: 47, Issue:4, 2019
Conjugated Linoleic Acid Effects on Cancer, Obesity, and Atherosclerosis: A Review of Pre-Clinical and Human Trials with Current Perspectives.Nutrients, , Feb-11, Volume: 11, Issue:2, 2019
A high linoleic acid diet exacerbates metabolic responses and gut microbiota dysbiosis in obese rats with diabetes mellitus.Food & function, , Feb-20, Volume: 10, Issue:2, 2019
Interaction of 17β-estradiol and dietary fatty acids on energy and glucose homeostasis in female mice.Nutritional neuroscience, , Volume: 21, Issue:10, 2018
Dietary linoleic acid interacts with FADS1 genetic variability to modulate HDL-cholesterol and obesity-related traits.Clinical nutrition (Edinburgh, Scotland), , Volume: 37, Issue:5, 2018
Adiposity Associated Plasma Linoleic Acid is Related to Demographic, Metabolic Health and Haplotypes of FADS1/2 Genes in Irish Adults.Molecular nutrition & food research, , Volume: 62, Issue:7, 2018
Divergent Response of Murine and Porcine Adipocytes to Stimulation of Browning Genes by 18-Carbon Polyunsaturated Fatty Acids and Beta-Receptor Agonists.Lipids, , Volume: 53, Issue:1, 2018
The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults.The British journal of nutrition, , Volume: 119, Issue:4, 2018
Essential Fatty Acids Linoleic Acid and α-Linolenic Acid Sex-Dependently Regulate Glucose Homeostasis in Obesity.Molecular nutrition & food research, , Volume: 62, Issue:17, 2018
Effects of a hypoenergetic diet rich in α-linolenic acid on fatty acid composition of serum phospholipids in overweight and obese patients with metabolic syndrome.Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 49, 2018
Alpha-linolenic acid and linoleic acid differentially regulate the skeletal muscle secretome of obese Zucker rats.Physiological genomics, , 08-01, Volume: 50, Issue:8, 2018
The Acute Effect of Oleic- or Linoleic Acid-Containing Meals on Appetite and Metabolic Markers; A Pilot Study in Overweight or Obese Individuals.Nutrients, , Sep-26, Volume: 10, Issue:10, 2018
Orosensory Detection of Dietary Fatty Acids Is Altered in CB₁RNutrients, , Sep-21, Volume: 10, Issue:10, 2018
Dietary effects of Raphanus sativus cv Sango on lipid and oxysterols accumulation in rat brain: A lipidomic study on a non-genetic obesity model.Chemistry and physics of lipids, , Volume: 207, Issue:Pt B, 2017
Lingual CD36 and nutritional status differentially regulate fat preference in obesity-prone and obesity-resistant rats.Physiology & behavior, , 05-15, Volume: 174, 2017
Discovery of Novel Lipid Profiles in PCOS: Do Insulin and Androgen Oppositely Regulate Bioactive Lipid Production?The Journal of clinical endocrinology and metabolism, , 03-01, Volume: 102, Issue:3, 2017
Altered Preconception Fatty Acid Intake Is Associated with Improved Pregnancy Rates in Overweight and Obese Women Undertaking in Vitro Fertilisation.Nutrients, , Jan-04, Volume: 8, Issue:1, 2016
Linoleic acid and the pathogenesis of obesity.Prostaglandins & other lipid mediators, , Volume: 125, 2016
Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile.Nutrients, , Jun-15, Volume: 8, Issue:6, 2016
Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties.Diabetes, , Volume: 65, Issue:9, 2016
Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells.Biochemical and biophysical research communications, , Mar-18, Volume: 471, Issue:4, 2016
Plasma phospholipids, non-esterified plasma polyunsaturated fatty acids and oxylipids are associated with BMI.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 95, 2015
Plasma nutrient biomarkers are associated with waist-to-height ratio in youth with type 1 diabetes.The Journal of nutrition, , Volume: 145, Issue:3, 2015
Three-dimensional spheroid cell model of in vitro adipocyte inflammation.Tissue engineering. Part A, , Volume: 21, Issue:11-12, 2015
Australia's nutrition transition 1961-2009: a focus on fats.The British journal of nutrition, , Aug-14, Volume: 114, Issue:3, 2015
No Difference in Perceived Intensity of Linoleic Acid in the Oral Cavity between Obese and Nonobese Individuals.Chemical senses, , Volume: 40, Issue:8, 2015
Reduced linoleic acid intake in early postnatal life improves metabolic outcomes in adult rodents following a Western-style diet challenge.Nutrition research (New York, N.Y.), , Volume: 35, Issue:9, 2015
Maternal supplementation with conjugated linoleic acid in the setting of diet-induced obesity normalises the inflammatory phenotype in mothers and reverses metabolic dysfunction and impaired insulin sensitivity in offspring.The Journal of nutritional biochemistry, , Volume: 26, Issue:12, 2015
A High Linoleic Acid Diet does not Induce Inflammation in Mouse Liver or Adipose Tissue.Lipids, , Volume: 50, Issue:11, 2015
Macronutrients: requirements and distribution.World review of nutrition and dietetics, , Volume: 111, 2015
Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion.PloS one, , Volume: 9, Issue:2, 2014
Nutrient-specific feeding and endocrine effects of jejunal infusions in obese animals.American journal of physiology. Regulatory, integrative and comparative physiology, , Mar-15, Volume: 306, Issue:6, 2014
Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency.EMBO reports, , Volume: 15, Issue:1, 2014
Deamidated lipocalin-2 induces endothelial dysfunction and hypertension in dietary obese mice.Journal of the American Heart Association, , Apr-10, Volume: 3, Issue:2, 2014
Obesity interferes with the orosensory detection of long-chain fatty acids in humans.The American journal of clinical nutrition, , Volume: 99, Issue:5, 2014
Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet.Lipids, , Volume: 49, Issue:1, 2014
CD36- and GPR120-mediated Ca²⁺ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice.Gastroenterology, , Volume: 146, Issue:4, 2014
Dietary linoleic acid and α-linolenic acid differentially affect renal oxylipins and phospholipid fatty acids in diet-induced obese rats.The Journal of nutrition, , Volume: 143, Issue:9, 2013
Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet.Lipids in health and disease, , Jan-08, Volume: 12, 2013
Kinetics of saturated, monounsaturated, and polyunsaturated fatty acids in humans.Diabetes, , Volume: 62, Issue:3, 2013
Adipocytes modulate the phenotype of human macrophages through secreted lipids.Journal of immunology (Baltimore, Md. : 1950), , Aug-01, Volume: 191, Issue:3, 2013
Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue.American journal of physiology. Regulatory, integrative and comparative physiology, , Volume: 305, Issue:11, 2013
Oro-gustatory perception of dietary lipids and calcium signaling in taste bud cells are altered in nutritionally obesity-prone Psammomys obesus.PloS one, , Volume: 8, Issue:8, 2013
Caenorhabditis elegans as a model to study the effectiveness and metabolic targets of dietary supplements used for obesity treatment: the specific case of a conjugated linoleic acid mixture (Tonalin).Journal of agricultural and food chemistry, , Nov-07, Volume: 60, Issue:44, 2012
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Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity.Obesity (Silver Spring, Md.), , Volume: 20, Issue:10, 2012
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Dietary L-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle.The Journal of nutritional biochemistry, , Volume: 22, Issue:5, 2011
Effects of trans-10,cis-12 CLA on liver size and fatty acid oxidation under energy restriction conditions in hamsters.Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 27, Issue:1, 2011
Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Comparison of hypolipidemic activity of synthetic gallic acid-linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice.Chemico-biological interactions, , Jul-30, Volume: 174, Issue:2, 2008
Conjugated linoleic acid and cardiac health: oxidative stress and energetic metabolism in standard and sucrose-rich diets.European journal of pharmacology, , Jan-28, Volume: 579, Issue:1-3, 2008
Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women.Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 22, Issue:10, 2006
Inflammation and conjugated linoleic acid: mechanisms of action and implications for human health.Journal of physiology and biochemistry, , Volume: 61, Issue:3, 2005
Relationships between serum unsaturated fatty acids and coronary risk factors: negative relations between nervonic acid and obesity-related risk factors.International heart journal, , Volume: 46, Issue:6, 2005
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Novel treatments for obesity and osteoporosis: targeting apoptotic pathways in adipocytes.Current medicinal chemistry, , Volume: 12, Issue:19, 2005
Epoxy-keto derivative of linoleic acid stimulates aldosterone secretion.Hypertension (Dallas, Tex. : 1979), , Volume: 43, Issue:2, 2004
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The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus.The Journal of nutrition, , Volume: 133, Issue:1, 2003
Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat.American journal of physiology. Endocrinology and metabolism, , Volume: 285, Issue:1, 2003
The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima fatty rats.Biochemical and biophysical research communications, , Jun-20, Volume: 306, Issue:1, 2003
The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects.International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, , Volume: 27, Issue:7, 2003
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Dietary conjugated linoleic acid reduces body fat mass and affects gene expression of proteins regulating energy metabolism in mice.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, , Volume: 133, Issue:3, 2002
Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome.Diabetes care, , Volume: 25, Issue:9, 2002
Changes in matrix proteoglycans induced by insulin and fatty acids in hepatic cells may contribute to dyslipidemia of insulin resistance.Diabetes, , Volume: 50, Issue:9, 2001
Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial.International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, , Volume: 25, Issue:8, 2001
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Effects of free fatty acids found increased in women who develop pre-eclampsia on the ability of endothelial cells to produce prostacyclin, cGMP and inhibit platelet aggregation.Scandinavian journal of clinical and laboratory investigation, , Volume: 54, Issue:7, 1994
Fatty acid composition of serum lipids of mothers and their babies after normal and hypertensive pregnancies.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 44, Issue:4, 1991
Essential fatty acid patterns in preeclampsia.Zentralblatt fur Gynakologie, , Volume: 108, Issue:16, 1986
An altered ratio of 18:2 (9,11) to 18:2 (9,12) linoleic acid in plasma phospholipids as a possible predictor of pre-eclampsia.Lancet (London, England), , Mar-09, Volume: 1, Issue:8428, 1985
Fatty acids in a high-fat diet potentially induce gastric parietal-cell damage and metaplasia in mice.Journal of gastroenterology, , Volume: 52, Issue:8, 2017
Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats.Japanese journal of cancer research : Gann, , Volume: 93, Issue:2, 2002
Vaccenic acid feeding increases tissue levels of conjugated linoleic acid and suppresses development of premalignant lesions in rat mammary gland.Nutrition and cancer, , Volume: 41, Issue:1-2, 2001
Conjugated linoleic acid does not inhibit development of aberrant crypt foci in colons of male Sprague-Dawley rats.Nutrition and cancer, , Volume: 41, Issue:1-2, 2001
Induction of apoptosis by conjugated linoleic acid in cultured mammary tumor cells and premalignant lesions of the rat mammary gland.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , Volume: 9, Issue:7, 2000
Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis.Cancer letters, , Sep-01, Volume: 143, Issue:2, 1999
Modulation of growth and cell turnover of preneoplastic lesions and of prostaglandin levels in rat pancreas by dietary fish oil.Carcinogenesis, , Volume: 15, Issue:10, 1994
Effects of dietary linoleic acid on pancreatic carcinogenesis in rats and hamsters.Cancer research, , Apr-15, Volume: 54, Issue:8, 1994
Octadeca-9,11-dienoic acid in cervical intraepithelial neoplasia: a colposcopic study.Clinica chimica acta; international journal of clinical chemistry, , Dec-29, Volume: 186, Issue:1, 1989
Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in exfoliated cells.Clinica chimica acta; international journal of clinical chemistry, , Mar-16, Volume: 163, Issue:2, 1987
Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in biopsy material.Clinica chimica acta; international journal of clinical chemistry, , Mar-16, Volume: 163, Issue:2, 1987
Association between maternal obesity, essential fatty acids and biomarkers of fetal liver function.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 190, 2023
The imperative of arachidonic acid in early human development.Progress in lipid research, , Volume: 91, 2023
Maternal Intake of Polyunsaturated Fatty Acids in Autism Spectrum Etiology and Its Relation to the Gut Microbiota: What Do We Know?Nutrients, , Mar-23, Volume: 15, Issue:7, 2023
Dietary Alpha-Linolenic Acid Supports High Retinal DHA Levels.Nutrients, , Jan-12, Volume: 14, Issue:2, 2022
Human milk fatty acid composition and its association with maternal blood and adipose tissue fatty acid content in a cohort of women from Europe.European journal of nutrition, , Volume: 61, Issue:4, 2022
Maternal diet high in linoleic acid alters offspring fatty acids and cardiovascular function in a rat model.The British journal of nutrition, , 02-28, Volume: 127, Issue:4, 2022
Linoleic acid reduces apoptosis via NF-κB during the in vitro development of induced parthenogenic porcine embryos.Theriogenology, , Jul-15, Volume: 187, 2022
Umbilical cord blood metabolomics: association with intrauterine hyperglycemia.Pediatric research, , Volume: 91, Issue:6, 2022
Linoleic acid and linoleate diols in neonatal cord blood influence birth weight.Frontiers in endocrinology, , Volume: 13, 2022
Effects of Zygote (Cambridge, England), , Volume: 30, Issue:6, 2022
Chronic consumption of a high linoleic acid diet during pregnancy, lactation and post-weaning period increases depression-like behavior in male, but not female offspring.Behavioural brain research, , 01-07, Volume: 416, 2022
Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner.International journal of molecular sciences, , Mar-14, Volume: 22, Issue:6, 2021
Intrauterine Transfer of Polyunsaturated Fatty Acids in Mother-Infant Dyads as Analyzed at Time of Delivery.Nutrients, , Mar-19, Volume: 13, Issue:3, 2021
Gestational diabetes mellitus decreased umbilical cord blood polyunsaturated fatty acids: a meta-analysis of observational studies.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 171, 2021
Fatty acid composition of adipose tissue at term indicates deficiency of arachidonic and docosahexaenoic acid and excessive linoleic acid supply in preterm infants.European journal of nutrition, , Volume: 60, Issue:2, 2021
Sex-Specific Differences in Lysine, 3-Hydroxybutyric Acid and Acetic Acid in Offspring Exposed to Maternal and Postnatal High Linoleic Acid Diet, Independent of Diet.International journal of molecular sciences, , Sep-23, Volume: 22, Issue:19, 2021
Changes in fatty acids in plasma and association with the inflammatory response in dairy cows abomasally infused with essential fatty acids and conjugated linoleic acid during late and early lactation.Journal of dairy science, , Volume: 103, Issue:12, 2020
Gestational diabetes mellitus prediction? A unique fatty acid profile study.Nutrition & diabetes, , 09-30, Volume: 10, Issue:1, 2020
Lipolysis modulates the biosynthesis of inflammatory lipid mediators derived from linoleic acid in adipose tissue of periparturient dairy cows.Journal of dairy science, , Volume: 103, Issue:2, 2020
The effect of high maternal linoleic acid on endocannabinoid signalling in rodent hearts.Journal of developmental origins of health and disease, , Volume: 11, Issue:6, 2020
Pregnancy and diet-related changes in the maternal gut microbiota following exposure to an elevated linoleic acid diet.American journal of physiology. Endocrinology and metabolism, , 02-01, Volume: 318, Issue:2, 2020
The Role of Arachidonic and Linoleic Acid Derivatives in Pathological Pregnancies and the Human Reproduction Process.International journal of molecular sciences, , Dec-17, Volume: 21, Issue:24, 2020
Linoleic acid-derived metabolites constitute the majority of oxylipins in the rat pup brain and stimulate axonal growth in primary rat cortical neuron-glia co-cultures in a sex-dependent manner.Journal of neurochemistry, , Volume: 152, Issue:2, 2020
Influence of fatty acid desaturase (FADS) genotype on maternal and child polyunsaturated fatty acids (PUFA) status and child health outcomes: a systematic review.Nutrition reviews, , 08-01, Volume: 78, Issue:8, 2020
Evaluation of the Stability of Fatty Acids in Erythrocytes from Human Umbilical Cord.Lipids, , Volume: 55, Issue:1, 2020
Validation of a Semi-Quantitative Food-Frequency Questionnaire for Dutch Pregnant Women from the General Population Using the Method or Triads.Nutrients, , 05-08, Volume: 12, Issue:5, 2020
Maternal High Linoleic Acid Alters Placental Fatty Acid Composition.Nutrients, , Jul-23, Volume: 12, Issue:8, 2020
Expression of cholesterol packaging and transport genes in human and rat placenta: impact of obesity and a high-fat diet.Journal of developmental origins of health and disease, , Volume: 11, Issue:3, 2020
Elevated maternal linoleic acid reduces circulating leptin concentrations, cholesterol levels and male fetal survival in a rat model.The Journal of physiology, , Volume: 597, Issue:13, 2019
Comparisons of Estimated Intakes and Plasma Concentrations of Selected Fatty Acids in Pregnancy.Nutrients, , Mar-06, Volume: 11, Issue:3, 2019
Circulating Linoleic Acid is Associated with Improved Glucose Tolerance in Women after Gestational Diabetes.Nutrients, , Nov-02, Volume: 10, Issue:11, 2018
Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.The Cochrane database of systematic reviews, , 10-01, Volume: 10, 2018
Modeled replacement of traditional soybean and canola oil with high-oleic varieties increases monounsaturated fatty acid and reduces both saturated fatty acid and polyunsaturated fatty acid intake in the US adult population.The American journal of clinical nutrition, , 09-01, Volume: 108, Issue:3, 2018
Saturated and unsaturated fatty acids differentially regulate in vitro and ex vivo placental antioxidant capacity.American journal of reproductive immunology (New York, N.Y. : 1989), , Volume: 80, Issue:3, 2018
Factors affecting human colostrum fatty acid profile: A case study.PloS one, , Volume: 12, Issue:4, 2017
Association between maternal intake of n-6 to n-3 fatty acid ratio during pregnancy and infant neurodevelopment at 6 months of age: results of the MOCEH cohort study.Nutrition journal, , 04-18, Volume: 16, Issue:1, 2017
Relationship between Changes in Fatty Acid Composition of the Erythrocyte Membranes and Fatty Acid Intake during Pregnancy in Pregnant Japanese Women.Annals of nutrition & metabolism, , Volume: 70, Issue:4, 2017
Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 117, 2017
Prepartum maternal diets supplemented with oilseeds alter the fatty acid profile in bovine neonatal plasma possibly through reduced placental expression of fatty acid transporter protein 4 and fatty acid translocase.Reproduction, fertility, and development, , Volume: 29, Issue:9, 2017
Maternal dietary linoleic acid supplementation promotes muscle fibre type transformation in suckling piglets.Journal of animal physiology and animal nutrition, , Volume: 101, Issue:6, 2017
Fatty acids profile in preterm Colostrum of Tunisian women. Association with selected maternal characteristics.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 112, 2016
Fate of orally administered radioactive fatty acids in the late-pregnant rat.American journal of physiology. Endocrinology and metabolism, , Mar-01, Volume: 310, Issue:5, 2016
Altered Preconception Fatty Acid Intake Is Associated with Improved Pregnancy Rates in Overweight and Obese Women Undertaking in Vitro Fertilisation.Nutrients, , Jan-04, Volume: 8, Issue:1, 2016
High Fat Diet Administration during Specific Periods of Pregnancy Alters Maternal Fatty Acid Profiles in the Near-Term Rat.Nutrients, , Jan-04, Volume: 8, Issue:1, 2016
Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile.Nutrients, , Jun-15, Volume: 8, Issue:6, 2016
Calcium and linoleic acid supplements in the prevention of preeclampsia.Colombia medica (Cali, Colombia), , 03-30, Volume: 47, Issue:1, 2016
Essential fatty acid supplementation during lactation is required to maximize the subsequent reproductive performance of the modern sow.Animal reproduction science, , Volume: 168, 2016
Dietary linoleic acid requirements in the presence of α-linolenic acid are lower than the historical 2 % of energy intake value, study in rats.The British journal of nutrition, , Apr-14, Volume: 113, Issue:7, 2015
Preeclampsia prevention: a case-control study nested in a cohort.Colombia medica (Cali, Colombia), , Dec-30, Volume: 46, Issue:4, 2015
Impact of dietary lipids on sow milk composition and balance of essential fatty acids during lactation in prolific sows.Journal of animal science, , Volume: 93, Issue:6, 2015
1.3.5 Fats. 1.3 Nutritional needs.World review of nutrition and dietetics, , Volume: 113, 2015
Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who Received Alpha Linolenic Acid from Chia Oil during Gestation and Nursing.Nutrients, , Aug-04, Volume: 7, Issue:8, 2015
A prepartum diet supplemented with oilseeds high in oleic or linoleic acid reduced GnRH-induced LH release in dairy cows during second week postpartum.Reproductive biology and endocrinology : RB&E, , Jul-03, Volume: 13, 2015
Arachidonic and linoleic acid derivatives impact oocyte ICSI fertilization--a prospective analysis of follicular fluid and a matched oocyte in a 'one follicle--one retrieved oocyte--one resulting embryo' investigational setting.PloS one, , Volume: 10, Issue:3, 2015
Maternal supplementation with conjugated linoleic acid in the setting of diet-induced obesity normalises the inflammatory phenotype in mothers and reverses metabolic dysfunction and impaired insulin sensitivity in offspring.The Journal of nutritional biochemistry, , Volume: 26, Issue:12, 2015
Metabolic conversion of intra-amniotically-injected deuterium-labeled essential fatty acids by fetal rats following maternal n-3 fatty acid deficiency.Biochimica et biophysica acta, , Volume: 1841, Issue:9, 2014
The omega-6 fatty acid linoleic acid is associated with risk of gastroschisis: a novel dietary risk factor.American journal of medical genetics. Part A, , Volume: 158A, Issue:4, 2012
Low linoleic acid may facilitate Δ6 desaturase activity and docosahexaenoic acid accretion in human fetal development.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 86, Issue:3, 2012
Modulation of fatty acid transport and metabolism by maternal obesity in the human full-term placenta.Biology of reproduction, , Volume: 87, Issue:1, 2012
Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women.Maternal & child nutrition, , Volume: 7, Issue:2, 2011
Fatty acid status in early life in low-income countries--overview of the situation, policy and research priorities.Maternal & child nutrition, , Volume: 7 Suppl 2, 2011
Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status.Maternal & child nutrition, , Volume: 7 Suppl 2, 2011
Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life.Maternal & child nutrition, , Volume: 7 Suppl 2, 2011
Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life.Maternal & child nutrition, , Volume: 7 Suppl 2, 2011
Effects of prepartum supplementation of linoleic and mid-oleic sunflower seed on cow performance, cow reproduction, and calf performance from birth through slaughter, and effects on intake and digestion in steers.Journal of animal science, , Volume: 89, Issue:11, 2011
Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women.The American journal of clinical nutrition, , Volume: 91, Issue:1, 2010
[Update of knowledge, recommendations and full consensus about the role of long chain polyunsaturated fatty acids in pregnancy, lactating period and first year of life.Asociación Española de Pediatría. Sociedad Española de Ginecología y Obstetricia. SocieMedicina clinica, , Jun-12, Volume: 135, Issue:2, 2010
A potential role for free fatty acids in the pathogenesis of preeclampsia.Journal of hypertension, , Volume: 27, Issue:6, 2009
Free fatty acid profiles in preeclampsia.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 81, Issue:1, 2009
Trans isomeric and LCPUFA are inversely correlated in erythrocyte membrane lipids at mid-gestation.Advances in experimental medicine and biology, , Volume: 646, 2009
Effect of dietary levels of corn oil on maternal arachidonic acid synthesis and fatty acid composition in lactating rats.Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 25, Issue:2, 2009
Plasma from preeclamptic women stimulates transendothelial migration of neutrophils.Reproductive sciences (Thousand Oaks, Calif.), , Volume: 16, Issue:3, 2009
Early life programming of immune and lung function: can we now exclude a role of arachidonic acid exposure?The British journal of nutrition, , Volume: 102, Issue:3, 2009
Impact of maternal dietary fatty acid composition on glucose and lipid metabolism in male rat offspring aged 105 d.The British journal of nutrition, , Volume: 102, Issue:2, 2009
Dietary unsaturated fatty acids influence preovulatory follicle characteristics in dairy cows.Reproduction (Cambridge, England), , Volume: 135, Issue:5, 2008
Milk in the island of Chole [Tanzania] is high in lauric, myristic, arachidonic and docosahexaenoic acids, and low in linoleic acid reconstructed diet of infants born to our ancestors living in tropical coastal regions.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 76, Issue:4, 2007
Maternal adipose tissue, maternal and cord blood essential fatty acids and their long-chain polyunsaturated derivatives composition after elective caesarean section.Early human development, , Volume: 83, Issue:7, 2007
Effects of postpartum dietary fat and body condition score at parturition on plasma, adipose tissue, and milk fatty acid composition of lactating beef cows.Journal of animal science, , Volume: 85, Issue:3, 2007
Fatty acid composition of plasma, medial basal hypothalamus, and uterine tissue in primiparous beef cows fed high-linoleate safflower seeds.Journal of animal science, , Volume: 85, Issue:6, 2007
Dietary docosahexaenoic acid alters pregnant rat reproductive tissue prostaglandin and matrix metalloproteinase production.The Journal of nutritional biochemistry, , Volume: 17, Issue:7, 2006
Maternal dietary fat alters amniotic fluid and fetal intestinal membrane essential n-6 and n-3 fatty acids in the rat.American journal of physiology. Gastrointestinal and liver physiology, , Volume: 290, Issue:3, 2006
Estrogens are potentially the only steroids with an antioxidant role in pregnancy: in vitro evidence.Acta obstetricia et gynecologica Scandinavica, , Volume: 85, Issue:9, 2006
Long-chain (n-3) polyunsaturated fatty acids are more efficient than alpha-linolenic acid in improving electroretinogram responses of puppies exposed during gestation, lactation, and weaning.The Journal of nutrition, , Volume: 135, Issue:8, 2005
Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation.Biochimica et biophysica acta, , Feb-21, Volume: 1687, Issue:1-3, 2005
The effect of a diet supplemented with the n-6 polyunsaturated fatty acid linoleic acid on prostaglandin production in early- and late-pregnant ewes.The Journal of endocrinology, , Volume: 184, Issue:1, 2005
Linoleic acid, but not oleic acid, upregulates production of interleukin-8 by human vascular smooth muscle cells via arachidonic acid metabolites under conditions of oxidative stress.Journal of the Society for Gynecologic Investigation, , Volume: 12, Issue:8, 2005
Factors affecting cryosurvival of nuclear-transferred bovine and swamp buffalo blastocysts: effects of hatching stage, linoleic acid-albumin in IVC medium and Ficoll supplementation to vitrification solution.Theriogenology, , Sep-15, Volume: 64, Issue:5, 2005
The effect of supplementation with n-6 polyunsaturated fatty acids on 1-, 2- and 3-series prostaglandin F production by ovine uterine epithelial cells.Biochimica et biophysica acta, , Sep-15, Volume: 1736, Issue:2, 2005
Effect of grazing and fat supplementation on production and reproduction of Holstein cows.Journal of dairy science, , Volume: 88, Issue:12, 2005
Calcium plus linoleic acid therapy for pregnancy-induced hypertension.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, , Volume: 91, Issue:3, 2005
Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-alpha in response to linoleic acid and oxidative stress.American journal of obstetrics and gynecology, , Volume: 193, Issue:3 Pt 1, 2005
Incomplete replacement of docosahexaenoic acid by n-6 docosapentaenoic acid in the rat retina after an n-3 fatty acid deficient diet.Experimental eye research, , Volume: 81, Issue:6, 2005
Influence of a maternal cholesterol-enriched diet on [1-14C]-linoleic acid and L-[4, 5-3H]-leucine entry in plasma of rabbit offspring.Life sciences, , Feb-20, Volume: 74, Issue:14, 2004
Alteration of prostaglandin production and agonist responsiveness by n-6 polyunsaturated fatty acids in endometrial cells from late-gestation ewes.The Journal of endocrinology, , Volume: 182, Issue:2, 2004
Dietary 18:3omega3 influences immune function and the tissue fatty acid response to antigens and adjuvant.Immunology letters, , Aug-15, Volume: 95, Issue:1, 2004
The effect of dietary supplementation with linoleic acid to late gestation ewes on the fatty acid composition of maternal and fetal plasma and tissues and the synthetic capacity of the placenta for 2-series prostaglandins.Biochimica et biophysica acta, , Nov-08, Volume: 1686, Issue:1-2, 2004
High linoleic acid safflower seed supplementation for gestating ewes: effects on ewe performance, lamb survival, and brown fat stores.Journal of animal science, , Volume: 82, Issue:12, 2004
Fertility following fixed-time AI in CIDR-treated beef heifers given GnRH or estradiol cypionate and fed diets supplemented with flax seed or sunflower seed.Theriogenology, , Apr-15, Volume: 61, Issue:6, 2004
Whole-body beta-oxidation of 18:2omega6 and 18:3omega3 in the pig varies markedly with weaning strategy and dietary 18:3omega3.Journal of lipid research, , Volume: 44, Issue:2, 2003
Effect of dietary fat sources on systemic and intrauterine synthesis of prostaglandins during early pregnancy in gilts.Journal of animal science, , Volume: 81, Issue:3, 2003
Polyunsaturated fatty acids and bovine interferon-tau modify phorbol ester-induced secretion of prostaglandin F2 alpha and expression of prostaglandin endoperoxide synthase-2 and phospholipase-A2 in bovine endometrial cells.Biology of reproduction, , Volume: 69, Issue:3, 2003
Flaxseed increased alpha-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 41, Issue:6, 2003
Impact of high flaxseed diet on mitogen-induced proliferation, IL-2 production, cell subsets and fatty acid composition of spleen cells from pregnant and F1 generation Sprague-Dawley rats.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 41, Issue:6, 2003
Effect of offering rumen-protected fat supplements on fertility and performance in spring-calving Holstein-Friesian cows.Animal reproduction science, , Nov-20, Volume: 79, Issue:1-2, 2003
Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women.The American journal of clinical nutrition, , Volume: 77, Issue:2, 2003
Effect of reduced maternal protein intake in pregnancy in the rat on the fatty acid composition of brain, liver, plasma, heart and lung phospholipids of the offspring after weaning.The British journal of nutrition, , Volume: 90, Issue:2, 2003
Oxidative stress reproduces placental abnormalities of preeclampsia.Hypertension in pregnancy, , Volume: 21, Issue:3, 2002
Intrauterine growth restriction is associated with changes in polyunsaturated fatty acid fetal-maternal relationships.Pediatric research, , Volume: 52, Issue:5, 2002
Leptin levels in rat offspring are modified by the ratio of linoleic to alpha-linolenic acid in the maternal diet.Journal of lipid research, , Volume: 43, Issue:10, 2002
Liver triacylglycerols and free fatty acids in streptozotocin-induced diabetic rats have atypical n-6 and n-3 pattern.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, , Volume: 132, Issue:3, 2002
The n-3 and n-6 polyunsaturated fatty acid composition of plasma phospholipids in pregnant women and their infants. relationship with maternal linoleic acid intake.Clinical chemistry and laboratory medicine, , Volume: 40, Issue:1, 2002
Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length.The American journal of clinical nutrition, , Volume: 73, Issue:4, 2001
[Prevention of gestational hypertension with calcium, linoleic acid, mono and polyunsaturated fatty acid supplements].Minerva ginecologica, , Volume: 53, Issue:4, 2001
Long-chain polyunsaturated fatty acid concentrations in human hindmilk are constant throughout twelve months of lactation.Advances in experimental medicine and biology, , Volume: 501, 2001
Estimation of dietary fat intake of Belgian pregnant women. Comparison of two methods.Annals of nutrition & metabolism, , Volume: 45, Issue:6, 2001
The composition of saturated fatty acids in plasma phospholipids changes in a way to counteract changes in the mean melting point during pregnancy.Lipids, , Volume: 36, Issue:1, 2001
Dietary trans fatty acids in early life: a review.Early human development, , Volume: 65 Suppl, 2001
Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 65, Issue:1, 2001
Maternal hypercholesterolemia and treatment during pregnancy influence the long-term progression of atherosclerosis in offspring of rabbits.Circulation research, , Nov-23, Volume: 89, Issue:11, 2001
Pre- and postnatal dietary conjugated linoleic acid alters adipose development, body weight gain and body composition in Sprague-Dawley rats.The Journal of nutrition, , Volume: 131, Issue:10, 2001
A calcium-independent phospholipase activity insensitive to bromoenol lactone mediates arachidonic acid release by lindane in rat myometrial cells.Life sciences, , Dec-14, Volume: 70, Issue:4, 2001
Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants.The American journal of clinical nutrition, , Volume: 71, Issue:1 Suppl, 2000
Transplacental effects of maternal feeding with high fat diets on lipid exchange and response of the splenic lymphoid system in mice offspring exposed to low doses of carcinogen.International journal of molecular medicine, , Volume: 6, Issue:3, 2000
Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta.The American journal of clinical nutrition, , Volume: 71, Issue:1 Suppl, 2000
A simple and efficient method for hemoglobin removal from mammalian tissue cytosol by zinc sulfate and its application to the study of lipoxygenase.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 62, Issue:2, 2000
Essential fatty acids and their long-chain polyunsaturated metabolites in maternal and cord plasma triglycerides during late gestation.Biology of the neonate, , Volume: 77, Issue:2, 2000
Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 63, Issue:3, 2000
Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 63, Issue:3, 2000
Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats.Pediatric research, , Volume: 47, Issue:2, 2000
Dietary conjugated linoleic acid consumption during pregnancy and lactation influences growth and tissue composition in weaned pigs.The Journal of nutrition, , Volume: 130, Issue:12, 2000
Commentary on the workshop statement. Essentiality of and recommended dietary intake of Omega-6 and Omega-3 fatty acids.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 63, Issue:3, 2000
Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 63, Issue:3, 2000
Human term placental lipoxygenase-mediated N-demethylation of phenothiazines and insecticides in the presence of linoleic acid.Placenta, , Volume: 21, Issue:7, 2000
Fatty acid ethyl esters: a novel biologic marker for heavy in utero ethanol exposure: a case report.Therapeutic drug monitoring, , Volume: 21, Issue:6, 1999
Maternal diet high in fat reduces docosahexaenoic acid in liver lipids of newborn and sucking rat pups.The British journal of nutrition, , Volume: 81, Issue:5, 1999
Investigation of a second 15S-lipoxygenase in humans and its expression in epithelial tissues.Advances in experimental medicine and biology, , Volume: 469, 1999
The influence of maternal diet on breast cancer risk among female offspring.Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 15, Issue:5, 1999
Hepatic fatty acid composition in periparturient dairy cows with fatty liver induced by intake of a high energy diet in the dry period.Journal of dairy science, , Volume: 82, Issue:2, 1999
Effect of maternal polyunsaturated fatty acid concentration on transport by the human placenta.Biology of the neonate, , Volume: 75, Issue:6, 1999
Linoleic acid kinetics and conversion to arachidonic acid in the pregnant and fetal baboon.Journal of lipid research, , Volume: 40, Issue:7, 1999
Prostaglandin f(2alpha) concentrations, fatty acid profiles, and fertility in lipid-infused postpartum beef heifers.Biology of reproduction, , Volume: 61, Issue:5, 1999
Lipoxygenase-another pathway for glutathione conjugation of xenobiotics: A study with human term placental lipoxygenase and ethacrynic acid.Archives of biochemistry and biophysics, , Nov-15, Volume: 371, Issue:2, 1999
[Effect of the long chain polyunsaturated fatty acids levels in mothers on fetuses].Zhonghua fu chan ke za zhi, , Volume: 33, Issue:12, 1998
Prevention of preeclampsia by linoleic acid and calcium supplementation: a randomized controlled trial.Obstetrics and gynecology, , Volume: 91, Issue:4, 1998
Stereochemistry of oxygenation of linoleic acid catalyzed by prostaglandin-endoperoxide H synthase-2.Archives of biochemistry and biophysics, , Jan-15, Volume: 349, Issue:2, 1998
Influence of linoleic/linolenic acid ratio in the diet of periparturient cattle on plasma concentrations of PGF2 alpha metabolite and placental expulsion rate.Theriogenology, , Volume: 49, Issue:3, 1998
Effects of aspirin and garlic on cyclooxygenase-induced chemiluminescence in human term placenta.Biochemical Society transactions, , Volume: 25, Issue:1, 1997
Fetal growth is associated positively with maternal intake of riboflavin and negatively with maternal intake of linoleic acid.Journal of the American Dietetic Association, , Volume: 97, Issue:8, 1997
Effects of dietary fat and season on steroid hormonal profiles before parturition and on hormonal, cholesterol, triglycerides, follicular patterns, and postpartum reproduction in Brahman cows.Journal of animal science, , Volume: 74, Issue:9, 1996
Preferential uptake of long chain polyunsaturated fatty acids by isolated human placental membranes.Molecular and cellular biochemistry, , Feb-09, Volume: 155, Issue:1, 1996
Asymmetric distribution of the plasma membrane fatty acid-binding protein (FABPpm) in the human placenta.Biochemical Society transactions, , Volume: 24, Issue:2, 1996
Linoleate, alpha-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys.Journal of lipid research, , Volume: 37, Issue:12, 1996
Increasing dietary linoleic acid in young rats increases and then decreases docosahexaenoic acid in retina but not in brain.Lipids, , Volume: 31, Issue:12, 1996
Some aspects of neonatal essential fatty acid status are altered by linoleic acid supplementation of women during pregnancy.The Journal of nutrition, , Volume: 125, Issue:11, 1995
Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice.Toxicology and applied pharmacology, , Volume: 131, Issue:1, 1995
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Hypoxia Promotes Prostate Cancer Aggressiveness by Upregulating EMT-Activator Zeb1 and SK3 Channel Expression.International journal of molecular sciences, , Jul-06, Volume: 21, Issue:13, 2020
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Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease.The Journal of nutrition, , Volume: 144, Issue:9, 2014
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Why isn't the causal relationship between linoleic acid and mortalities from coronary heart disease and stroke revealed by clinical studies?World review of nutrition and dietetics, , Volume: 96, 2007
The Japan Society for Lipid Nutrition recommends to reduce the intake of linoleic acid. A review and critique of the scientific evidence.World review of nutrition and dietetics, , Volume: 92, 2003
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Inflammatory response to dietary linoleic acid depends on FADS1 genotype.The American journal of clinical nutrition, , 01-01, Volume: 109, Issue:1, 2019
Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota?Antioxidants & redox signaling, , 01-10, Volume: 30, Issue:2, 2019
Effects of a hypoenergetic diet rich in α-linolenic acid on fatty acid composition of serum phospholipids in overweight and obese patients with metabolic syndrome.Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 49, 2018
Hydroxyoctadecadienoic acids: Oxidised derivatives of linoleic acid and their role in inflammation associated with metabolic syndrome and cancer.European journal of pharmacology, , Aug-15, Volume: 785, 2016
The Effect of Resveratrol and Quercetin Treatment on PPAR Mediated Uncoupling Protein (UCP-) 1, 2, and 3 Expression in Visceral White Adipose Tissue from Metabolic Syndrome Rats.International journal of molecular sciences, , Jul-05, Volume: 17, Issue:7, 2016
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Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD.The European respiratory journal, , Volume: 47, Issue:6, 2016
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Low linoleic acid foods with added DHA given to Malawian children with severe acute malnutrition improve cognition: a randomized, triple-blinded, controlled clinical trial.The American journal of clinical nutrition, , 05-01, Volume: 115, Issue:5, 2022
Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA.The British journal of nutrition, , Jun-28, Volume: 105, Issue:12, 2011
Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life.Maternal & child nutrition, , Volume: 7 Suppl 2, 2011
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The effect of alpha-linolenic acid and linoleic acid on the growth and development of formula-fed infants: a systematic review and meta-analysis of randomized controlled trials.Lipids, , Volume: 40, Issue:1, 2005
Diets with low n-6:n-3 PUFA ratio protects rats from fructose-induced dyslipidemia and associated hepatic changes: Comparison between 18:3 n-3 and long-chain n-3 PUFA.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 155, 2020
Is There a Link between Zinc Intake and Status with Plasma Fatty Acid Profile and Desaturase Activities in Dyslipidemic Subjects?Nutrients, , Dec-28, Volume: 12, Issue:1, 2019
An overview of the biologic effects of omega-6 oxylipins in humans.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 137, 2018
Inverse association between serum phospholipid oleic acid and insulin resistance in subjects with primary dyslipidaemia.Clinical nutrition (Edinburgh, Scotland), , Volume: 30, Issue:5, 2011
Conjugated linoleic acid and cardiac health: oxidative stress and energetic metabolism in standard and sucrose-rich diets.European journal of pharmacology, , Jan-28, Volume: 579, Issue:1-3, 2008
Fatty acids cause alterations of human arterial smooth muscle cell proteoglycans that increase the affinity for low-density lipoprotein.Arteriosclerosis, thrombosis, and vascular biology, , Volume: 26, Issue:1, 2006
Replacement of saturated fatty acids with linoleic acid in western diet attenuates atherosclerosis in a mouse model with inducible ablation of hepatic LDL receptor.Scientific reports, , 10-06, Volume: 13, Issue:1, 2023
The effects of dietary linoleic acid on reducing serum cholesterol and atherosclerosis development are nullified by a high-cholesterol diet in male and female apoE-deficient mice.The British journal of nutrition, , 03-14, Volume: 129, Issue:5, 2023
[no title available]Marine drugs, , Dec-04, Volume: 20, Issue:12, 2022
Differential Effect of Dietary Supplementation with a Soybean Oil Enriched in Oleic Acid versus Linoleic Acid on Plasma Lipids and Atherosclerosis in LDLR-Deficient Mice.International journal of molecular sciences, , Jul-29, Volume: 23, Issue:15, 2022
[Compatibility mechanism of Trichosanthis Fructus-Allii Macrostemonis Bulbus combination against atherosclerosis: based on metabolomics and network pharmacology].Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, , Volume: 47, Issue:22, 2022
Serum Non-Esterified Fatty Acids, Carotid Artery Intima-Media Thickness and Flow-Mediated Dilation in Older Adults: The Cardiovascular Health Study (CHS).Nutrients, , Aug-31, Volume: 13, Issue:9, 2021
Vasculometabolic and Inflammatory Effects of Aldosterone in Obesity.The Journal of clinical endocrinology and metabolism, , 08-01, Volume: 105, Issue:8, 2020
Conjugated Linoleic Acid Effects on Cancer, Obesity, and Atherosclerosis: A Review of Pre-Clinical and Human Trials with Current Perspectives.Nutrients, , Feb-11, Volume: 11, Issue:2, 2019
The effects of pro- and anti-atherosclerotic factors on intracellular nucleotide concentration in murine endothelial cells.Nucleosides, nucleotides & nucleic acids, , Volume: 37, Issue:11, 2018
ω-6 (18:2) and ω-3 (18:3) fatty acids in reconstituted high-density lipoproteins show different functionality of anti-atherosclerotic properties and embryo toxicity.The Journal of nutritional biochemistry, , Volume: 26, Issue:12, 2015
n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis.The British journal of nutrition, , Nov-14, Volume: 110, Issue:9, 2013
Polyunsaturated fatty acid relatively decreases cholesterol content in THP-1 macrophage-derived foam cell: partly correlates with expression profile of CIDE and PAT members.Lipids in health and disease, , Jul-23, Volume: 12, 2013
S-adenosyl methionine prevents endothelial dysfunction by inducing heme oxygenase-1 in vascular endothelial cells.Molecules and cells, , Volume: 36, Issue:4, 2013
Conjugated linoleic acid isomers may diminish human macrophages adhesion to endothelial surface.International journal of food sciences and nutrition, , Volume: 63, Issue:1, 2012
Obesity modifies the association between plasma phospholipid polyunsaturated fatty acids and markers of inflammation: the Multi-Ethnic Study of Atherosclerosis.International journal of obesity (2005), , Volume: 36, Issue:6, 2012
Imaging of lipids in atherosclerotic lesion in aorta from ApoE/LDLR-/- mice by FT-IR spectroscopy and Hierarchical Cluster Analysis.The Analyst, , Dec-21, Volume: 136, Issue:24, 2011
Modulation of leptin levels by oxidized linoleic acid: a connection to atherosclerosis?Journal of medicinal food, , Volume: 14, Issue:4, 2011
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Evolutionary aspects of the dietary omega-6:omega-3 fatty acid ratio: medical implications.World review of nutrition and dietetics, , Volume: 100, 2009
Conjugated linoleic acid isomers inhibit platelet-derived growth factor-induced NF-kappaB transactivation and collagen formation in human vascular smooth muscle cells.European journal of nutrition, , Volume: 47, Issue:2, 2008
Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms.Atherosclerosis, , Volume: 199, Issue:2, 2008
Engineering away lysosomal junk: medical bioremediation.Rejuvenation research, , Volume: 10, Issue:3, 2007
Mechanisms by which dietary fats affect coronary heart disease mortality.World review of nutrition and dietetics, , Volume: 96, 2007
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The Acute Effect of Oleic- or Linoleic Acid-Containing Meals on Appetite and Metabolic Markers; A Pilot Study in Overweight or Obese Individuals.Nutrients, , Sep-26, Volume: 10, Issue:10, 2018
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Replacement of saturated fatty acids with linoleic acid in western diet attenuates atherosclerosis in a mouse model with inducible ablation of hepatic LDL receptor.Scientific reports, , 10-06, Volume: 13, Issue:1, 2023
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Fatty acid pattern in serum is associated with bone mineralisation in healthy 8-year-old children.The British journal of nutrition, , Volume: 102, Issue:3, 2009
Dietary beta-tocopherol and linoleic acid, serum insulin, and waist circumference predict circulating sex hormone-binding globulin in premenopausal women.The Journal of nutrition, , Volume: 139, Issue:6, 2009
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Conjugated Linoleic Acid (CLA) inhibits new vessel growth in the mammalian brain.Brain research, , Jun-05, Volume: 1213, 2008
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Intracerebroventricular administration of conjugated linoleic acid (CLA) inhibits food intake by decreasing gene expression of NPY and AgRP.Neuroscience letters, , May-18, Volume: 418, Issue:3, 2007
Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARalpha target genes in rat liver.The Journal of nutrition, , Volume: 137, Issue:1, 2007
Nutritional therapy improves function and complements corticosteroid intervention in mdx mice.Muscle & nerve, , Volume: 33, Issue:1, 2006
The (n-3) fatty acid dose, independent of the (n-6) to (n-3) fatty acid ratio, affects the plasma fatty acid profile of normal dogs.The Journal of nutrition, , Volume: 136, Issue:9, 2006
Chorda tympani nerve transection alters linoleic acid taste discrimination by male and female rats.Physiology & behavior, , Oct-30, Volume: 89, Issue:3, 2006
Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 19, Issue:12, 2005
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Altering the fatty acids in milk fat by including canola seed in dairy cattle diets.Journal of dairy science, , Volume: 88, Issue:9, 2005
The dietary alpha-linolenic acid to linoleic acid ratio does not affect the serum lipoprotein profile in humans.The Journal of nutrition, , Volume: 135, Issue:12, 2005
Combined effects of dietary protein type and fat level on the body fat-reducing activity of conjugated linoleic acid (CLA) in rats.Bioscience, biotechnology, and biochemistry, , Volume: 69, Issue:12, 2005
The role of insulin, glucagon, dexamethasone, and leptin in the regulation of ketogenesis and glycogen storage in primary cultures of porcine hepatocytes prepared from 60 kg pigs.Domestic animal endocrinology, , Volume: 27, Issue:2, 2004
Acute changes in dietary omega-3 fatty acid intake lowers soluble interleukin-6 receptor in healthy adult normal weight and overweight males.Cytokine, , Jun-07, Volume: 26, Issue:5, 2004
Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature.The American journal of clinical nutrition, , Volume: 79, Issue:3, 2004
Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity.Biochemical and biophysical research communications, , Mar-12, Volume: 315, Issue:3, 2004
Arachidonic acid in adipose tissue is associated with nonfatal acute myocardial infarction in the central valley of Costa Rica.The Journal of nutrition, , Volume: 134, Issue:11, 2004
Effects of dietary alpha linolenic acid on cholesterol metabolism in male and female hamsters of the LPN strain.The Journal of nutritional biochemistry, , Volume: 15, Issue:1, 2004
The effect of six different C18 fatty acids on body fat and energy metabolism in mice.The British journal of nutrition, , Volume: 92, Issue:3, 2004
Differential effects of dietary fatty acids on rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase activity and gene expression.Biochimica et biophysica acta, , Nov-08, Volume: 1686, Issue:1-2, 2004
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Prolonged feeding of mice with conjugated linoleic acid increases hepatic fatty acid synthesis relative to oxidation.The Journal of nutritional biochemistry, , Volume: 15, Issue:11, 2004
The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus.The Journal of nutrition, , Volume: 133, Issue:1, 2003
Intramuscular injection of antigens and adjuvant preferentially decreases 18:2n-6 and 18:3n-3 in pig neck muscle.Lipids, , Volume: 38, Issue:12, 2003
Effect of soy protein isolate and conjugated linoleic acid on the growth of Dunning R-3327-AT-1 rat prostate tumors.The Prostate, , Feb-15, Volume: 54, Issue:3, 2003
Dietary conjugated linoleic acid lowers plasma cholesterol during cholesterol supplementation, but accentuates the atherogenic lipid profile during the acute phase response in hamsters.The Journal of nutrition, , Volume: 133, Issue:2, 2003
Whole-body beta-oxidation of 18:2omega6 and 18:3omega3 in the pig varies markedly with weaning strategy and dietary 18:3omega3.Journal of lipid research, , Volume: 44, Issue:2, 2003
Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid.The Journal of nutrition, , Volume: 133, Issue:3, 2003
Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat.American journal of physiology. Endocrinology and metabolism, , Volume: 285, Issue:1, 2003
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Peroxisome proliferator-activated receptor alpha is not the exclusive mediator of the effects of dietary cyclic FA in mice.Lipids, , Volume: 38, Issue:9, 2003
CLA and body weight regulation in humans.Lipids, , Volume: 38, Issue:2, 2003
Association of liver steatosis with lipid oversecretion and hypotriglyceridaemia in C57BL/6j mice fed trans-10,cis-12-linoleic acid.FEBS letters, , Jul-10, Volume: 546, Issue:2-3, 2003
A subchronic 90-day oral rat toxicity study and in vitro genotoxicity studies with a conjugated linoleic acid product.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 41, Issue:12, 2003
Dietary conjugated linoleic acids as free fatty acids and triacylglycerols similarly affect body composition and energy balance in mice.The Journal of nutrition, , Volume: 133, Issue:10, 2003
The effect of polyunsaturated fatty acids, including conjugated linoleic acid, on calcium absorption and bone metabolism and composition in young growing rats.The British journal of nutrition, , Volume: 90, Issue:4, 2003
Dietary conjugated linolenic acid in relation to CLA differently modifies body fat mass and serum and liver lipid levels in rats.Lipids, , Volume: 37, Issue:4, 2002
Liver triacylglycerols and free fatty acids in streptozotocin-induced diabetic rats have atypical n-6 and n-3 pattern.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, , Volume: 132, Issue:3, 2002
Effects of supplementation with high linoleic or oleic cracked safflower seeds on postpartum reproduction and calf performance of primiparous beef heifers.Journal of animal science, , Volume: 80, Issue:8, 2002
High intake, but not low intake, of CLA impairs weight gain in growing mice.Lipids, , Volume: 37, Issue:7, 2002
Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse.Journal of lipid research, , Volume: 43, Issue:9, 2002
Optimizing DHA levels in piglets by lowering the linoleic acid to alpha-linolenic acid ratio.Journal of lipid research, , Volume: 43, Issue:9, 2002
Leptin levels in rat offspring are modified by the ratio of linoleic to alpha-linolenic acid in the maternal diet.Journal of lipid research, , Volume: 43, Issue:10, 2002
Different sources of dietary n-6 polyunsaturated fatty acids and their effects on antibody responses in chickens.British poultry science, , Volume: 43, Issue:4, 2002
Adipose depletion and apoptosis induced by trans-10, cis-12 conjugated linoleic Acid in mice.Obesity research, , Volume: 10, Issue:12, 2002
Conjugated linoleic acid reduces body fats and cytokine levels of mice.Bioscience, biotechnology, and biochemistry, , Volume: 66, Issue:4, 2002
Dietary supplementation with conjugated linoleic acid does not improve nutritional status of tumor-bearing rats.Research in nursing & health, , Volume: 25, Issue:1, 2002
Dose-dependent effect of dietary conjugated linoleic acid on the growth of rat hepatoma dRLh-84 cells in vivo.Journal of nutritional science and vitaminology, , Volume: 48, Issue:6, 2002
Effect of dietary conjugated linoleic acid on the growth rate of live birds and on the abdominal fat content and quality of broiler meat.Poultry science, , Volume: 81, Issue:3, 2002
Dietary fat and meat intake in relation to risk of type 2 diabetes in men.Diabetes care, , Volume: 25, Issue:3, 2002
Carp oil or oleic acid, but not linoleic acid or linolenic acid, inhibits tumor growth and metastasis in Lewis lung carcinoma-bearing mice.The Journal of nutrition, , Volume: 132, Issue:7, 2002
The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta.The Journal of nutrition, , Volume: 132, Issue:5, 2002
The effects of dietary conjugated nonadecadienoic acid on body composition in mice.Biochimica et biophysica acta, , Oct-31, Volume: 1533, Issue:3, 2001
Evaluation of conjugated linoleic acid and dietary antibiotics as growth promotants in weanling pigs.Journal of animal science, , Volume: 79, Issue:10, 2001
Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome P4502E1.Biochemical and biophysical research communications, , Nov-09, Volume: 288, Issue:4, 2001
Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice.American journal of physiology. Endocrinology and metabolism, , Volume: 281, Issue:5, 2001
Conjugated linoleic acid supplementation in humans--metabolic effects.Lipids, , Volume: 36, Issue:8, 2001
Plasma fatty acid levels in autistic children.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 65, Issue:1, 2001
Differences between humans and mice in efficacy of the body fat lowering effect of conjugated linoleic acid: role of metabolic rate.The Journal of nutrition, , Volume: 131, Issue:7, 2001
Dietary conjugated linoleic acid reduces adiposity in lean but not obese Zucker rats.The Journal of nutrition, , Volume: 131, Issue:6, 2001
Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats.Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 17, Issue:5, 2001
Site-dependent modulating effects of conjugated fatty acids from safflower oil in a rat two-stage carcinogenesis model in female Sprague-Dawley rats.Cancer letters, , Jul-10, Volume: 168, Issue:1, 2001
Conjugated linoleic acid (CLA), body fat, and apoptosis.Obesity research, , Volume: 9, Issue:2, 2001
Increased energy metabolism and suppressed body fat accumulation in mice by a low concentration of conjugated linoleic acid.Bioscience, biotechnology, and biochemistry, , Volume: 65, Issue:10, 2001
Beta-oxidation of linoleate in obese men undergoing weight loss.The American journal of clinical nutrition, , Volume: 73, Issue:4, 2001
Dietary supplementation with conjugated linoleic acid does not alter the resistance of mice to Listeria monocytogenes infection.Lipids, , Volume: 36, Issue:2, 2001
Maternal essential fatty acid deficiency depresses serum leptin levels in suckling rat pups.Journal of lipid research, , Volume: 42, Issue:3, 2001
Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid.Biochimica et biophysica acta, , Nov-30, Volume: 1534, Issue:1, 2001
Dietary antioxidant vitamins, retinol, and breast cancer incidence in a cohort of Swedish women.International journal of cancer, , Feb-15, Volume: 91, Issue:4, 2001
Influence of conjugated linoleic acid on body composition and target gene expression in peroxisome proliferator-activated receptor alpha-null mice.Biochimica et biophysica acta, , Oct-31, Volume: 1533, Issue:3, 2001
Effect of medium-chain fatty acid positional distribution in dietary triacylglycerol on lymphatic lipid transport and chylomicron composition in rats.Lipids, , Volume: 35, Issue:12, 2000
Linoleic acid metabolism in the spontaneously diabetic rat: delta6-desaturase activity vs. product/precursor ratios.Lipids, , Volume: 35, Issue:12, 2000
Effect of dietary linoleate/alpha-linolenate balance on the brain lipid composition, reproductive outcome and behavior of rats during their prenatal and postnatal development.Bioscience, biotechnology, and biochemistry, , Volume: 64, Issue:11, 2000
Dietary conjugated linoleic acid did not alter immune status in young healthy women.Lipids, , Volume: 35, Issue:10, 2000
Intestinal absorption and postabsorptive metabolism of linoleic acid in rats with short-term bile duct ligation.American journal of physiology. Gastrointestinal and liver physiology, , Volume: 279, Issue:6, 2000
Contribution of dietary and newly formed arachidonic acid to milk secretion in women on low fat diets.Advances in experimental medicine and biology, , Volume: 478, 2000
Energy supplements rich in linoleic acid improve body weight and essential fatty acid status of cystic fibrosis patients.Journal of pediatric gastroenterology and nutrition, , Volume: 31, Issue:4, 2000
Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice.The Journal of nutrition, , Volume: 130, Issue:10, 2000
Changes in body composition with conjugated linoleic acid.Journal of the American College of Nutrition, , Volume: 19, Issue:4, 2000
Isomers of conjugated linoleic acid (CLA) are incorporated into egg yolk lipids by CLA-fed laying hens.The Journal of nutrition, , Volume: 130, Issue:8, 2000
Effects of conjugated linoleic acid. 2. Embryonic and neonatal growth and circulating lipids.Poultry science, , Volume: 79, Issue:6, 2000
Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number.The Journal of nutrition, , Volume: 130, Issue:6, 2000
Effects of dietary fat type and level on broiler breeder performance.Poultry science, , Volume: 79, Issue:5, 2000
Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions.American journal of physiology. Regulatory, integrative and comparative physiology, , Volume: 278, Issue:3, 2000
Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake.The American journal of physiology, , Volume: 276, Issue:4, 1999
Bile diversion in rats leads to a decreased plasma concentration of linoleic acid which is not due to decreased net intestinal absorption of dietary linoleic acid.Biochimica et biophysica acta, , Apr-19, Volume: 1438, Issue:1, 1999
Fatty acid composition of human milk in Kuwaiti mothers.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, , Volume: 124, Issue:3, 1999
Effects of reduced dietary linoleic acid intake, alone or combined with an algal source of docosahexaenoic acid, on MDA-MB-231 breast cancer cell growth and apoptosis in nude mice.Nutrition and cancer, , Volume: 35, Issue:1, 1999
Biliary phospholipid secretion is not required for intestinal absorption and plasma status of linoleic acid in mice.Biochimica et biophysica acta, , Oct-18, Volume: 1441, Issue:1, 1999
Prostaglandin f(2alpha) concentrations, fatty acid profiles, and fertility in lipid-infused postpartum beef heifers.Biology of reproduction, , Volume: 61, Issue:5, 1999
Pathophysiologic studies of experimental chronic pancreatitis in rats induced by injection of zein-oleic acid-linoleic acid solution into the pancreatic duct.Pancreas, , Volume: 16, Issue:3, 1998
Dietary methionine level affects linoleic acid metabolism through phosphatidylethanolamine N-methylation in rats.Lipids, , Volume: 33, Issue:3, 1998
Inhibitory effect of linoleic acid on chain elongation and desaturation of 18:2 c,t isomers in lactating and neonatal rats.Lipids, , Volume: 33, Issue:4, 1998
Toxicological evaluation of dietary conjugated linoleic acid in male Fischer 344 rats.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 36, Issue:5, 1998
A linoleic acid enriched diet increases serum cholesterol esterification by lecithin:cholesterol acyltransferase in meal-fed rats.Annals of nutrition & metabolism, , Volume: 42, Issue:4, 1998
Effect of dietary linoleic/alpha-linolenic acid ratio on growth and visual function of term infants.The Journal of pediatrics, , Volume: 131, Issue:2, 1997
Modulation of adjuvant-induced arthritis by dietary arachidonic acid in essential fatty acid-deficient rats.Lipids, , Volume: 32, Issue:9, 1997
Depletion of linoleate induced by weight cycling is independent of extent of calorie restriction.The American journal of physiology, , Volume: 272, Issue:1 Pt 2, 1997
Visual acuity and blood lipids in term infants fed human milk or formulae.Lipids, , Volume: 32, Issue:1, 1997
Conjugated linoleic acid modulates hepatic lipid composition in mice.Lipids, , Volume: 32, Issue:2, 1997
Comparative hypocholesterolemic effects of capybara (Hydrochoerus hydrochaeris dabbenei) oil, horse oil, and sardine oil in cholesterol-fed rats.Lipids, , Volume: 32, Issue:4, 1997
Diet and breast cancer: studies in laboratory animals.The Journal of nutrition, , Volume: 127, Issue:5 Suppl, 1997
Dietary linoleic acid intake controls the arterial blood plasma concentration and the rates of growth and linoleic acid uptake and metabolism in hepatoma 7288CTC in Buffalo rats.The Journal of nutrition, , Volume: 127, Issue:7, 1997
Essential fatty acid preparation improves biochemical and cognitive functions in experimental allergic encephalomyelitis rats.European journal of pharmacology, , Jun-05, Volume: 328, Issue:1, 1997
Dietary unsaturated fatty acids affect antibody responses and growth of chickens divergently selected for humoral responses to sheep red blood cells.Poultry science, , Volume: 76, Issue:8, 1997
Functional effects of increasing omega-3 fatty acid intake.The Journal of pediatrics, , Volume: 131, Issue:2, 1997
Effect of linoleic acid intake on growth of infants with cystic fibrosis.The American journal of clinical nutrition, , Volume: 63, Issue:5, 1996
Involvement of (n-6) essential fatty acids and prostaglandins in liver lipid accumulation in Japanese quail.American journal of veterinary research, , Volume: 57, Issue:3, 1996
Effects of two dietary fat levels and four dietary linoleic acid levels on mammary tumor development in Balb/c-MMTV mice under ad libitum feeding conditions.Nutrition and cancer, , Volume: 25, Issue:2, 1996
Serum alpha tocopherol concentrations and cholesterol ester fatty acid composition in 70-year-old men reflect those 20 years earlier.European journal of clinical nutrition, , Volume: 50, Issue:6, 1996
Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion.Nutrition and cancer, , Volume: 26, Issue:2, 1996
Effects of dietary fat and season on steroid hormonal profiles before parturition and on hormonal, cholesterol, triglycerides, follicular patterns, and postpartum reproduction in Brahman cows.Journal of animal science, , Volume: 74, Issue:9, 1996
Influence of dietary fats upon systolic blood pressure in the rat.International journal of food sciences and nutrition, , Volume: 47, Issue:5, 1996
[Polyunsaturated fatty acid biogenesis is impaired in spontaneously hypertensive rat in relation to the pathogenesis of hypertension].Archives des maladies du coeur et des vaisseaux, , Volume: 89, Issue:8, 1996
Effect of supplementation of milk fat with peanut oil on blood lipids and lipoproteins in infants.International journal of food sciences and nutrition, , Volume: 46, Issue:4, 1995
Effect of low levels of dietary fish oil on fatty acid desaturation and tissue fatty acids in obese and lean rats.Lipids, , Volume: 30, Issue:9, 1995
Role of dietary gamma-linolenic acid in liver lipid metabolism in Japanese quail.British poultry science, , Volume: 36, Issue:5, 1995
Further investigations on the effect of dietary manipulations of nutrients on early egg weight.Poultry science, , Volume: 74, Issue:1, 1995
Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats.The American journal of physiology, , Volume: 268, Issue:2 Pt 2, 1995
Effect of dietary linoleic acid on the tryptophan-niacin metabolism in streptozotocin diabetic rats.Comparative biochemistry and physiology. Part A, Physiology, , Volume: 111, Issue:4, 1995
Effect of carbohydrate source on lipid metabolism in lactating mice and on pup development.The British journal of nutrition, , Volume: 74, Issue:6, 1995
Long-chain polyunsaturated fatty acids in children with severe protein-energy malnutrition with and without human immunodeficiency virus-1 infection.The American journal of clinical nutrition, , Volume: 62, Issue:6, 1995
Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro.Nutrition and cancer, , Volume: 24, Issue:1, 1995
Modulation of growth and cell turnover of preneoplastic lesions and of prostaglandin levels in rat pancreas by dietary fish oil.Carcinogenesis, , Volume: 15, Issue:10, 1994
Incorporation of delta 6- and delta 5-desaturation fatty acids in liver microsomal lipid classes of obese Zucker rats fed n - 6 or n - 3 fatty acids.Biochimica et biophysica acta, , Aug-25, Volume: 1214, Issue:1, 1994
Application of the balance method to determining accumulation, metabolism, and apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat.Metabolism: clinical and experimental, , Volume: 43, Issue:8, 1994
Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats.Obesity research, , Volume: 1, Issue:2, 1993
Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio.Proceedings of the National Academy of Sciences of the United States of America, , Nov-01, Volume: 90, Issue:21, 1993
Formation of prostanoids and hydroxy fatty acids by stimulated peritoneal mast cells: role of the dietary fat type in rat.Biochimica et biophysica acta, , Apr-07, Volume: 1167, Issue:2, 1993
Age-related changes in delta 6 and delta 5 desaturase activities in rat liver microsomes.Lipids, , Volume: 28, Issue:4, 1993
Kinetics of the inhibition of tumour growth in mice by eicosapentaenoic acid-reversal by linoleic acid.Biochemical pharmacology, , Jun-09, Volume: 45, Issue:11, 1993
Long-term effects of linoleic-acid-enriched diet on albuminuria and lipid levels in type 1 (insulin-dependent) diabetic patients with elevated urinary albumin excretion.Diabetologia, , Volume: 35, Issue:2, 1992
Essential fatty acids are not required for wound healing.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 45, Issue:4, 1992
Effects of alpha-tocopherol and tocotrienols on blood pressure and linoleic acid metabolism in the spontaneously hypertensive rat (SHR).Bioscience, biotechnology, and biochemistry, , Volume: 56, Issue:9, 1992
Fatty acid composition of adipose tissue in Ethiopian immigrants: a prospective study during their first year in Israel.Israel journal of medical sciences, , Volume: 27, Issue:5, 1991
Effects of dietary pantethine levels on contents of fatty acids and thiobarbituric acid reactive substances in the liver of rats orally administered varying amounts of autoxidized linoleate.Journal of nutritional science and vitaminology, , Volume: 37, Issue:1, 1991
Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans.The American journal of clinical nutrition, , Volume: 54, Issue:4, 1991
Effects of type of dietary fat on phorbol ester-elicited tumor promotion and other events in mouse skin.Cancer research, , Feb-01, Volume: 51, Issue:3, 1991
Metabolites of cis,trans, and trans,cis isomers of linoleic acid in mice and incorporation into tissue lipids.Biochimica et biophysica acta, , Apr-03, Volume: 1082, Issue:3, 1991
Lipid profiles, serum immunoglobulins, dietary intake, and drug use of older rural Iowa women.Journal of the American Dietetic Association, , Volume: 91, Issue:6, 1991
Dietary olive and safflower oils in promotion of DMBA-induced mammary tumorigenesis in rats.Nutrition and cancer, , Volume: 13, Issue:3, 1990
Modification of rat platelet fatty acid composition by dietary lipids of animal and vegetable origin.The Journal of nutrition, , Volume: 120, Issue:5, 1990
Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats.The American journal of physiology, , Volume: 259, Issue:1 Pt 1, 1990
Spontaneous diabetes in BB rats: evidence for insulin dependent liver microsomal delta 6 and delta 5 desaturase activities.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, , Volume: 22, Issue:8, 1990
Azaserine-induced pancreatic carcinogenesis in rats: promotion by a diet rich in saturated fat and inhibition by a standard laboratory chow.Cancer letters, , Dec-17, Volume: 55, Issue:3, 1990
Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes.The Journal of experimental medicine, , Mar-01, Volume: 171, Issue:3, 1990
Modulation of mouse mammary tumor growth and linoleate enhanced metastasis by oleate.The Journal of nutrition, , Volume: 120, Issue:2, 1990
Acute and chronic effects of eicosapentaenoic acid (EPA) on the cardiovascular system.Research communications in chemical pathology and pharmacology, , Volume: 66, Issue:3, 1989
Fish oil reduces cholesterol and arachidonic acid content more efficiently in rats fed diets containing low linoleic acid to saturated fatty acid ratios.Biochimica et biophysica acta, , Oct-14, Volume: 962, Issue:3, 1988
Effects of type and amount of dietary fat on rabbit and rat lymphocyte proliferation in vitro.The Journal of nutrition, , Volume: 118, Issue:1, 1988
Effect of dietary linoleic acid and essential fatty acid deficiency on resting metabolism, nonshivering thermogenesis and brown adipose tissue in the rat.The Journal of nutrition, , Volume: 118, Issue:5, 1988
The influence of linoleate and vitamin E from sunflower seed oil on platelet function and prostaglandin production in the common marmoset monkey.Journal of nutritional science and vitaminology, , Volume: 33, Issue:4, 1987
Effect of autoxidized linoleic acid on the contents of cytochrome P-450 and cytochrome b5, and drug-metabolizing enzyme activities in rat liver.Journal of nutritional science and vitaminology, , Volume: 33, Issue:1, 1987
Long-term effects of a linoleic acid-enriched diet, changes in body weight and alcohol consumption on serum total and HDL-cholesterol.Atherosclerosis, , Volume: 66, Issue:1-2, 1987
Effect of dietary lipids on renal function in rats with subtotal nephrectomy.Kidney international, , Volume: 32, Issue:3, 1987
Enhancement of metastasis from a transplantable mouse mammary tumor by dietary linoleic acid.Cancer research, , Dec-01, Volume: 47, Issue:23, 1987
Effects of selenium-deficient diets on the production of prostaglandins and other oxygenated metabolites of arachidonic acid and linoleic acid by rat and rabbit aortae.Biochimica et biophysica acta, , Sep-25, Volume: 921, Issue:2, 1987
[Chronologic studies of the effects of a hypoproteinic diet followed by an equilibrated diet on delta-6 and delta-5 desaturations of linoleic acid in liver microsomes in the rat].Archives internationales de physiologie et de biochimie, , Volume: 94, Issue:2, 1986
High fat diets varying in ratios of polyunsaturated to saturated fatty acid and linoleic to linolenic acid: a comparison of rat neural and red cell membrane phospholipids.The Journal of nutrition, , Volume: 116, Issue:5, 1986
Effect of dietary menhaden oil on tumor cell loss and the accumulation of mass of a transplantable mammary adenocarcinoma in BALB/c mice.Journal of the National Cancer Institute, , Volume: 76, Issue:6, 1986
Retention of linoleic acid in carcass lipids of rats fed different levels of essential fatty acids.Lipids, , Volume: 21, Issue:2, 1986
The importance of lipid type in the diet after burn injury.Annals of surgery, , Volume: 204, Issue:1, 1986
Effect of total parenteral nutrition with linoleic acid-rich emulsions on tissue omega 6 and omega 3 fatty acids in the rat.Lipids, , Volume: 21, Issue:2, 1986
Spontaneous tumor incidence in female brown Norway rats after lifelong diets high and low in linoleic acid.Journal of the National Cancer Institute, , Volume: 74, Issue:2, 1985
Blood pressure and dietary polyunsaturated and saturated fats: a controlled trial.Clinical science (London, England : 1979), , Volume: 69, Issue:2, 1985
Essential fatty acids in the liver and adipose tissue of genetically obese mice: effect of supplemental linoleic and gamma-linolenic acids.The British journal of nutrition, , Volume: 53, Issue:3, 1985
Abnormal essential fatty acid composition of tissue lipids in genetically diabetic mice is partially corrected by dietary linoleic and gamma-linolenic acids.The British journal of nutrition, , Volume: 53, Issue:3, 1985
Influence of different supplements of N-3 polyunsaturated fatty acids on blood and tissue lipids in rats receiving high intakes of linoleic acid.Annals of nutrition & metabolism, , Volume: 29, Issue:3, 1985
Incorporation of 14C into tissue lipids after oral administration of [1-14C]linoleic acid in rats fed different levels of essential fatty acids.The Journal of nutrition, , Volume: 115, Issue:10, 1985
Varying fat and protein in diets of growing large white turkeys.Poultry science, , Volume: 64, Issue:10, 1985
Growth and carcass composition of broilers fed sunflower oil and olive oil.British poultry science, , Volume: 25, Issue:2, 1984
Effects of dietary vitamin E on serum and pulmonary fatty acids and prostaglandins in rats fed excess linoleic acid.The Journal of nutrition, , Volume: 114, Issue:6, 1984
Essential fatty acid status and characteristics associated with colostrum-deprived gnotobiotic and conventional lambs. Growth, organ development, cell membrane integrity and factors associated with lower bowel function.Journal of animal science, , Volume: 58, Issue:4, 1984
Effect of dietary linoleic acid on the tissue levels of zinc and copper, and serum high density lipoprotein cholesterol.Atherosclerosis, , Volume: 50, Issue:2, 1984
Effect of dietary unsaturated and saturated fats on azoxymethane-induced colon carcinogenesis in rats.Cancer research, , Volume: 44, Issue:4, 1984
Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats.Prostaglandins, , Volume: 27, Issue:3, 1984
Dissociation of effects of dietary fatty acids on blood pressure and prostanoid metabolism in Goldblatt hypertensive rats.Journal of hypertension, , Volume: 2, Issue:1, 1984
Physiological effects of varying dietary linoleic acid in spontaneously hypertensive rats.Annals of nutrition & metabolism, , Volume: 26, Issue:4, 1982
Rates of depletion of linoleic acid from fat depots of selected lines of mice differing in growth rate and adiposity.Lipids, , Volume: 17, Issue:3, 1982
Influence of dietary linoleic acid content on blood pressure regulation in salt-loaded rats (with special reference to the prostaglandin system).Advances in lipid research, , Volume: 18, 1981
EFFECT OF A SERUM CHOLESTEROL-LOWERING DIET ON COMPOSITION OF DEPOT FAT IN MAN.The American journal of clinical nutrition, , Volume: 16, 1965
ACTION OF FATS AND LINOLEIC ACID ON INTESTINAL SYNTHESIS OF THIAMINE IN THIAMINE-DEFICIENT RATS.The British journal of nutrition, , Volume: 19, 1965
THE EFFECT OF DIET ON THE LEVEL OF PLASMA CHOLESTEROL AND THE DEGREE OF ATHEROMATOUS DEGENERATION IN THE RABBIT.The British journal of nutrition, , Volume: 18, 1964
FATTY ACID COMPOSITION OF PLASMA AND LIVER LIPID COMPONENTS AS INFLUENCED BY DIET IN THE GROWING CHICK.The Journal of nutrition, , Volume: 81, 1963
STUDIES OF DIETARY FATS AND VITAMIN D TOXICITY IN THE RAT.Canadian journal of biochemistry and physiology, , Volume: 41, 1963
STUDY ON REGRESSION OF ATHEROSCLEROSIS IN RABBITS.Nagoya journal of medical science, , Volume: 26, 1963
The effect of saponin, sterols and linoleic acid on the weight increase of growing rats.The British journal of nutrition, , Volume: 14, 1960
Selected metabolic results of the Leipzig gerontological longitudinal study.Zeitschrift fur Alternsforschung, , Volume: 38, Issue:2
Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice.Anticancer research, , Volume: 18, Issue:3A
Impaired catecholamine inactivation. A prohypertensive stimulus after dietary linoleate deficiency in salt-loaded rats?Hypertension (Dallas, Tex. : 1979), , Volume: 5, Issue:6
[Effect of diets of various levels of linoleic acid on prostanoid biosynthesis and arterial blood pressure in rats].Voprosy pitaniia, , Issue:4
Conjugated linoleic acid reduces body fat in healthy exercising humans.The Journal of international medical research, , Volume: 29, Issue:5
Medium chain triglycerides (MCT) in aging and arteriosclerosis.Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, , Volume: 6, Issue:3-4
Fatty acid changes in plasma lipids and lymphocyte phospholipids after infusion of intralipid to newborn infants.JPEN. Journal of parenteral and enteral nutrition, , Volume: 9, Issue:6
Effect of arachidonic acid-rich oil on lipids and arachidonate metabolites in ethanol- treated rats.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 64, Issue:4-5
Effects of dietary conjugated linoleic acid on lymphocyte function and growth of mammary tumors in mice.Anticancer research, , Volume: 17, Issue:2A
Supplemental parenteral nutrition in cystic fibrosis.JPEN. Journal of parenteral and enteral nutrition, , Volume: 10, Issue:3
An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans.Nutrition journal, , Jan-16, Volume: 6, 2007
The effect of polyunsaturated fatty acids, including conjugated linoleic acid, on calcium absorption and bone metabolism and composition in young growing rats.The British journal of nutrition, , Volume: 90, Issue:4, 2003
ROLE OF ARACHIDONIC ACID IN NUTRITIONAL ENCEPHALOMALACIA: INTERRELATIONSHIP OF ESSENTIAL AND NONESSENTIAL POLYUNSATURATED FATTY ACIDS.Archives of biochemistry and biophysics, , Volume: 104, 1964
EFFECT OF HIGH LINOLEIC ACID AND ANTIOXIDANT DEFICIENT DIET ON BLOOD SERUM PROTEINS IN CHICKS.Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), , Volume: 115, 1964
Linoleic acid as causative agent of encephalomalacia in chickens fed oxidized fats.Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), , Volume: 103, 1960
POSSIBLE ROLE OF VITAMIN E IN UNSATURATED FATTY ACID METABOLISM.Federation proceedings, , Volume: 23
[Platycladi Semen oil ameliorates Aβ_(25-35)-induced brain injury in mice based on network pharmacology and gut microbiota].Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, , Volume: 48, Issue:15, 2023
Conjugated Linoleic Acid (CLA) inhibits new vessel growth in the mammalian brain.Brain research, , Jun-05, Volume: 1213, 2008
Free fatty acids in cerebrospinal fluids from patients with traumatic brain injury.Neuroscience letters, , Oct-02, Volume: 349, Issue:2, 2003
Effects of siRNA-dependent knock-down of cardiolipin synthase and tafazzin on mitochondria and proliferation of glioma cells.Biochimica et biophysica acta. Molecular and cell biology of lipids, , Volume: 1863, Issue:4, 2018
The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells.Journal of experimental & clinical cancer research : CR, , 10-22, Volume: 35, Issue:1, 2016
Antitumor efficacy of a novel CLA-PTX microemulsion against brain tumors: in vitro and in vivo findings.International journal of nanomedicine, , Volume: 7, 2012
Study of in vitro and in vivo effect of docosahexaenoic acid on rat C6 glioma.Journal of experimental therapeutics & oncology, , Volume: 8, Issue:2, 2009
The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression.Lipids in health and disease, , Nov-16, Volume: 7, 2008
Stimulation of myelin proteolipid protein gene expression by eicosapentaenoic acid in C6 glioma cells.Neurochemistry international, , Volume: 44, Issue:5, 2004
The importance of linoleic acid in the total fatty acid compositions of benign and malignant neuroglial tumors.Advances in experimental medicine and biology, , Volume: 400B, 1997
Mechanisms of glial swelling by arachidonic acid.Acta neurochirurgica. Supplementum, , Volume: 60, 1994
Intratumoral gamma-linoleic acid therapy of human gliomas.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 45, Issue:3, 1992
FATTY ACID ANALYSIS OF TWO EXPERIMENTAL TRANSMISSIBLE GLIAL TUMORS BY GAS-LIQUID CHROMATOGRAPHY.Cancer research, , Volume: 25, 1965
Hyaluronic Acid-Modified Nanoparticles Self-Assembled from Linoleic Acid-Conjugated Chitosan for the Codelivery of miR34a and Doxorubicin in Resistant Breast Cancer.Molecular pharmaceutics, , 01-03, Volume: 19, Issue:1, 2022
Linoleic-acid-substituted polyethylenimine to silence heat shock protein 90B1 (HSP90B1) to inhibit migration of breast cancer cells.The journal of gene medicine, , Volume: 24, Issue:6, 2022
Identification of Molecular Basis for Objective Discrimination of Breast Cancer Cells (MCF-7) from Normal Human Mammary Epithelial Cells by Raman Microspectroscopy and Multivariate Curve Resolution Analysis.International journal of molecular sciences, , Jan-14, Volume: 22, Issue:2, 2021
Identification of Novel Diagnostic Biomarkers in Breast Cancer Using Targeted Metabolomic Profiling.Clinical breast cancer, , Volume: 21, Issue:3, 2021
Docosahexaenoic acid (DHA) and linoleic acid (LA) modulate the expression of breast cancer involved miRNAs in MDA-MB-231 cell line.Clinical nutrition ESPEN, , Volume: 46, 2021
Linoleic acid induces secretion of extracellular vesicles from MDA-MB-231 breast cancer cells that mediate cellular processes involved with angiogenesis in HUVECs.Prostaglandins & other lipid mediators, , Volume: 153, 2021
Enabling Combinatorial siRNA Delivery against Apoptosis-Related Proteins with Linoleic Acid and α-Linoleic Acid Substituted Low Molecular Weight Polyethylenimines.Pharmaceutical research, , Feb-03, Volume: 37, Issue:3, 2020
Self-Strengthened Oxidation-Responsive Bioactivating Prodrug Nanosystem with Sequential and Synergistically Facilitated Drug Release for Treatment of Breast Cancer.ACS applied materials & interfaces, , May-29, Volume: 11, Issue:21, 2019
Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.Molecular and cellular biochemistry, , Volume: 457, Issue:1-2, 2019
Association between blood polyunsaturated fatty acid levels and depressive symptoms in breast cancer survivors.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 139, 2018
Migration and invasion induced by linoleic acid are mediated through fascin in MDA-MB-231 breast cancer cells.Molecular and cellular biochemistry, , Volume: 443, Issue:1-2, 2018
Linoleic acid induces an increased response to insulin in MDA-MB-231 breast cancer cells.Journal of cellular biochemistry, , Volume: 119, Issue:7, 2018
Role of Daucosterol Linoleate on Breast Cancer: Studies on Apoptosis and Metastasis.Journal of agricultural and food chemistry, , Jun-20, Volume: 66, Issue:24, 2018
Therapeutic efficacy of lipid emulsions of docetaxel-linoleic acid conjugate in breast cancer.International journal of pharmaceutics, , Jul-30, Volume: 546, Issue:1-2, 2018
Agonist-induced activation of human FFA1 receptor signals to extracellular signal-regulated kinase 1 and 2 through Gq- and Gi-coupled signaling cascades.Cellular & molecular biology letters, , Volume: 22, 2017
Linoleic acid induces migration and invasion through FFAR4- and PI3K-/Akt-dependent pathway in MDA-MB-231 breast cancer cells.Medical oncology (Northwood, London, England), , Volume: 34, Issue:6, 2017
Linoleic acid and breast cancer risk: a meta-analysis.Public health nutrition, , Volume: 19, Issue:8, 2016
Synergistic anti-tumor effects of melatonin and PUFAs from walnuts in a murine mammary adenocarcinoma model.Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 31, Issue:4, 2015
Raman microspectroscopy of noncancerous and cancerous human breast tissues. Identification and phase transitions of linoleic and oleic acids by Raman low-temperature studies.The Analyst, , Apr-07, Volume: 140, Issue:7, 2015
Extracellular vesicles from MDA-MB-231 breast cancer cells stimulated with linoleic acid promote an EMT-like process in MCF10A cells.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 91, Issue:6, 2014
Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 90, Issue:4, 2014
Role of arachidonic acid metabolism in Stat5 activation induced by oleic acid in MDA-MB-231 breast cancer cells.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 88, Issue:3, 2013
A proof of principle clinical trial to determine whether conjugated linoleic acid modulates the lipogenic pathway in human breast cancer tissue.Breast cancer research and treatment, , Volume: 138, Issue:1, 2013
Role of LOXs and COX-2 on FAK activation and cell migration induced by linoleic acid in MDA-MB-231 breast cancer cells.Cellular oncology (Dordrecht), , Volume: 36, Issue:1, 2013
Mouse mammary gland is refractory to the effects of ethanol after natural lactation.Comparative medicine, , Volume: 63, Issue:1, 2013
Dietary conjugated linoleic acid and long-chain n-3 fatty acids in mammary and prostate cancer protection: a review.International journal of food sciences and nutrition, , Volume: 63, Issue:1, 2012
Enhanced anticancer activity of gemcitabine coupling with conjugated linoleic acid against human breast cancer in vitro and in vivo.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 82, Issue:2, 2012
Anticancer effects of garlic and garlic-derived compounds for breast cancer control.Anti-cancer agents in medicinal chemistry, , Volume: 11, Issue:3, 2011
Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells.Carcinogenesis, , Volume: 31, Issue:3, 2010
Circadian stage-dependent inhibition of human breast cancer metabolism and growth by the nocturnal melatonin signal: consequences of its disruption by light at night in rats and women.Integrative cancer therapies, , Volume: 8, Issue:4, 2009
Eleostearic Acid inhibits breast cancer proliferation by means of an oxidation-dependent mechanism.Cancer prevention research (Philadelphia, Pa.), , Volume: 2, Issue:10, 2009
Melatonin, sleep disturbance and cancer risk.Sleep medicine reviews, , Volume: 13, Issue:4, 2009
Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers.Cancer causes & control : CCC, , Volume: 20, Issue:4, 2009
Dietary stearate reduces human breast cancer metastasis burden in athymic nude mice.Clinical & experimental metastasis, , Volume: 26, Issue:5, 2009
Dietary fat, cooking fat, and breast cancer risk in a multiethnic population.Nutrition and cancer, , Volume: 60, Issue:4, 2008
5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic acid, and risk for breast cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , Volume: 17, Issue:10, 2008
Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation.Environmental health perspectives, , Volume: 115, Issue:12, 2007
Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay.Journal of natural products, , Volume: 69, Issue:4, 2006
[Unsaturated fatty acids intake and breast cancer risk: epidemiological data review].Bulletin du cancer, , Volume: 92, Issue:7, 2005
Differential inhibition of fatty acid transport in tissue-isolated steroid receptor negative human breast cancer xenografts perfused in situ with isomers of conjugated linoleic acid.Cancer letters, , Jun-08, Volume: 209, Issue:1, 2004
Mechanisms of cancer inhibition by melatonin.Journal of pineal research, , Volume: 37, Issue:3, 2004
Differential effects of delivery of omega-3 fatty acids to human cancer cells by low-density lipoproteins versus albumin.Clinical cancer research : an official journal of the American Association for Cancer Research, , Dec-15, Volume: 10, Issue:24, 2004
No relations between breast cancer risk and fatty acids of erythrocyte membranes in postmenopausal women of the Malmö Diet Cancer cohort (Sweden).European journal of clinical nutrition, , Volume: 58, Issue:5, 2004
An overview of the effect of linoleic and conjugated-linoleic acids on the growth of several human tumor cell lines.International journal of cancer, , Dec-20, Volume: 112, Issue:6, 2004
Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry).Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 11, Issue:1, 2004
Conjugated linoleic acid content in breast adipose tissue of breast cancer patients and the risk of metastasis.Nutrition and cancer, , Volume: 45, Issue:1, 2003
Growth and fatty acid metabolism of human breast cancer (MCF-7) xenografts in nude rats: impact of constant light-induced nocturnal melatonin suppression.Breast cancer research and treatment, , Volume: 79, Issue:3, 2003
n-6 Polyunsaturated fatty acids and breast cancer.Nutrition and cancer, , Volume: 47, Issue:2, 2003
Association between E-cadherin expression by human colon, bladder and breast cancer cells and the 13-HODE:15-HETE ratio. A possible role of their metastatic potential.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 68, Issue:1, 2003
Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands Cohort Study on Diet and Cancer.The American journal of clinical nutrition, , Volume: 76, Issue:4, 2002
In vitro pro- and antioxidant properties of estrogens.The Journal of steroid biochemistry and molecular biology, , Volume: 81, Issue:3, 2002
An enriched mixture of trans-10,cis-12-CLA inhibits linoleic acid metabolism and PGE2 synthesis in MDA-MB-231 cells.Nutrition and cancer, , Volume: 44, Issue:2, 2002
Conjugated linoleic acid and the risk of breast cancer.IARC scientific publications, , Volume: 156, 2002
n-3 fatty acids and breast cancer.IARC scientific publications, , Volume: 156, 2002
Conjugated linoleic acid content in breast adipose tissue is not associated with the relative risk of breast cancer in a population of French patients.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , Volume: 11, Issue:7, 2002
Cis-polyunsaturated fatty acids stimulate beta1 integrin-mediated adhesion of human breast carcinoma cells to type IV collagen by activating protein kinases C-epsilon and -mu.Cancer research, , Mar-15, Volume: 61, Issue:6, 2001
Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines.Carcinogenesis, , Volume: 22, Issue:6, 2001
Dietary antioxidant vitamins, retinol, and breast cancer incidence in a cohort of Swedish women.International journal of cancer, , Feb-15, Volume: 91, Issue:4, 2001
Effect of omega-3 fatty acid (docosahexanoic acid) on BRCA1 gene expression and growth in MCF-7 cell line.Cancer biotherapy & radiopharmaceuticals, , Volume: 16, Issue:3, 2001
Modulation of arachidonic acid distribution by conjugated linoleic acid isomers and linoleic acid in MCF-7 and SW480 cancer cells.Lipids, , Volume: 36, Issue:10, 2001
Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator.Journal of cancer research and clinical oncology, , Volume: 127, Issue:4, 2001
Effect of omega-6 polyunsaturated fatty acid (linoleic acid) on BRCA1 gene expression in MCF-7 cell line.Cancer letters, , Jun-30, Volume: 154, Issue:2, 2000
Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women.Nutrition and cancer, , Volume: 38, Issue:2, 2000
The influence of maternal diet on breast cancer risk among female offspring.Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 15, Issue:5, 1999
Antiangiogenicity of docosahexaenoic acid and its role in the suppression of breast cancer cell growth in nude mice.International journal of oncology, , Volume: 15, Issue:5, 1999
Linoleic acid intake and cancer risk: a review and meta-analysis.The American journal of clinical nutrition, , Volume: 68, Issue:1, 1998
The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells.British journal of cancer, , Volume: 77, Issue:5, 1998
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Fatty acid composition of adipose tissue, an indication of dietary fatty acids, and breast cancer prognosis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, , Volume: 15, Issue:4, 1997
The growth inhibitory effect of conjugated linoleic acid on MCF-7 cells is related to estrogen response system.Cancer letters, , Jun-24, Volume: 116, Issue:2, 1997
Supplementation of MCF-7 cells with essential fatty acids induces the activation of protein kinase C in response to IGF-1.Journal of lipid mediators and cell signalling, , Volume: 16, Issue:3, 1997
Adipose fatty acids and cancers of the breast, prostate and colon: an ecological study. EURAMIC Study Group.International journal of cancer, , Aug-07, Volume: 72, Issue:4, 1997
Characterization of a 15-lipoxygenase in human breast carcinoma BT-20 cells: stimulation of 13-HODE formation by TGF alpha/EGF.Biochemical and biophysical research communications, , Feb-03, Volume: 231, Issue:1, 1997
Specific fatty acids and risks of breast and prostate cancer: dietary intake.The American journal of clinical nutrition, , Volume: 66, Issue:6 Suppl, 1997
Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line.Clinical & experimental metastasis, , Volume: 14, Issue:2, 1996
Long-term effects of participation in a randomized trial of a low-fat, high-carbohydrate diet.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , Volume: 5, Issue:3, 1996
Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor.Nutrition and cancer, , Volume: 25, Issue:3, 1996
In vitro effects of eicosanoid synthesis inhibitors in the presence of linoleic acid on MDA-MB-231 human breast cancer cells.Breast cancer research and treatment, , Volume: 37, Issue:1, 1996
Effects of indomethacin with or without linoleic acid on human breast cancer cells in vitro.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 52, Issue:6, 1995
Review of the effects of dietary fat on experimental mammary gland tumorigenesis: role of lipid peroxidation.Free radical biology & medicine, , Volume: 18, Issue:4, 1995
Unsaturated fatty acid effects on human breast cancer cell adhesion.Nutrition and cancer, , Volume: 24, Issue:1, 1995
Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro.Nutrition and cancer, , Volume: 24, Issue:1, 1995
Comparison of linoleic acid and eicosapentaenoic acid incorporation into human breast cancer cells.Lipids, , Volume: 29, Issue:12, 1994
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Stimulation of type IV collagenase expression by linoleic acid in a metastatic human breast cancer cell line.Cancer letters, , Jan-15, Volume: 76, Issue:1, 1994
ZR-75-1 breast cancer cells generate nonconjugated steroids from low density lipoprotein-incorporated lipoidal dehydroepiandrosterone.Endocrinology, , Volume: 133, Issue:2, 1993
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The aldehydic metabolites of linoleic acid are cytotoxic against human breast cancer cells.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 43, Issue:4, 1991
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Serum n-6 polyunsaturated fatty acids and risk of atrial fibrillation: the Kuopio Ischaemic Heart Disease Risk Factor Study.European journal of nutrition, , Volume: 61, Issue:4, 2022
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An overview of the biologic effects of omega-6 oxylipins in humans.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 137, 2018
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Circulating omega-6 polyunsaturated fatty acids and total and cause-specific mortality: the Cardiovascular Health Study.Circulation, , Oct-07, Volume: 130, Issue:15, 2014
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ACP Journal Club. Review: replacing dietary saturated fatty acids with n-6 polyunsaturated fatty acids does not reduce mortality.Annals of internal medicine, , May-21, Volume: 158, Issue:10, 2013
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Omega3 fatty acids effectively prevent coronary heart disease and other late-onset diseases--the excessive linoleic acid syndrome.World review of nutrition and dietetics, , Volume: 96, 2007
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Low Percentage of Vegetable Fat in Red Blood Cells Is Associated with Worse Glucose Metabolism and Incidence of Type 2 Diabetes.Nutrients, , Mar-25, Volume: 14, Issue:7, 2022
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Determination of antioxidant capacity, α-amylase and lipase inhibitory activity of Crotalaria juncea Linn in vitro inhibitory activity of Crotalaria Juncea Linn.Journal of dietary supplements, , Volume: 11, Issue:2, 2014
Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients.Archives of medical research, , Volume: 43, Issue:1, 2012
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The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus.The Journal of nutrition, , Volume: 133, Issue:1, 2003
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The chlorophyll metabolite phytanic acid is a natural rexinoid--potential for treatment and prevention of diabetes.Medical hypotheses, , Volume: 56, Issue:2, 2001
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Evaluation of Gastroprotective Activity of Linoleic Acid on Gastric Ulcer in a Mice Model.Current pharmaceutical design, , Volume: 28, Issue:8, 2022
Nanoparticle formulation of mycophenolate mofetil achieves enhanced efficacy against hepatocellular carcinoma by targeting tumour-associated fibroblast.Journal of cellular and molecular medicine, , Volume: 25, Issue:7, 2021
Theaphenon E prevents fatty liver disease and increases CD4+ T cell survival in mice fed a high-fat diet.Clinical nutrition (Edinburgh, Scotland), , Volume: 40, Issue:1, 2021
Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXO.Life science alliance, , Volume: 3, Issue:2, 2020
Spectrofluorometric Analysis of Autofluorescing Components of Crude Serum from a Rat Liver Model of Ischemia and Reperfusion.Molecules (Basel, Switzerland), , Mar-14, Volume: 25, Issue:6, 2020
Ethanolamides of essential α-linolenic and linoleic fatty acids suppress short-term food intake in rats.Food & function, , Apr-30, Volume: 11, Issue:4, 2020
Group V secreted phospholipase AThe Journal of biological chemistry, , 07-24, Volume: 295, Issue:30, 2020
Modulatory Effect of Linoleic Acid During Journal of microbiology and biotechnology, , May-28, Volume: 30, Issue:5, 2020
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.Proceedings of the National Academy of Sciences of the United States of America, , 12-08, Volume: 117, Issue:49, 2020
Proopiomelanocortin Processing in the Hypothalamus Is Directly Regulated by Saturated Fat: Implications for the Development of Obesity.Neuroendocrinology, , Volume: 110, Issue:1-2, 2020
Expression of cholesterol packaging and transport genes in human and rat placenta: impact of obesity and a high-fat diet.Journal of developmental origins of health and disease, , Volume: 11, Issue:3, 2020
Untargeted metabolomics reveals the effect of lovastatin on steroid-induced necrosis of the femoral head in rabbits.Journal of orthopaedic surgery and research, , Oct-28, Volume: 15, Issue:1, 2020
A Diet Enriched in Palmitate and Deficient in Linoleate Exacerbates Oxidative Stress and Amyloid-β Burden in the Hippocampus of 3xTg-AD Mouse Model of Alzheimer's Disease.Journal of Alzheimer's disease : JAD, , Volume: 68, Issue:1, 2019
Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.Journal of medicinal chemistry, , 06-13, Volume: 62, Issue:11, 2019
Linoleic Acid Metabolite DiHOME Decreases Post-ischemic Cardiac Recovery in Murine Hearts.Cardiovascular toxicology, , Volume: 19, Issue:4, 2019
Low linoleic and high docosahexaenoic acids in a severe phenotype of transgenic cystic fibrosis mice.Experimental biology and medicine (Maywood, N.J.), , Volume: 243, Issue:5, 2018
The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain.Biochimica et biophysica acta. Molecular and cell biology of lipids, , Volume: 1863, Issue:7, 2018
Zinc and linoleic acid pre-treatment attenuates biochemical and histological changes in the midbrain of rats with rotenone-induced Parkinsonism.BMC neuroscience, , 05-09, Volume: 19, Issue:1, 2018
Determination of an Optimized Weighting Factor of Liver Parenchyma for Six-point Interference Dixon Fat Percentage Imaging Accuracy in Nonalcoholic Fatty Liver Disease Rat Model.Academic radiology, , Volume: 25, Issue:12, 2018
Deuterium-reinforced linoleic acid lowers lipid peroxidation and mitigates cognitive impairment in the Q140 knock in mouse model of Huntington's disease.The FEBS journal, , Volume: 285, Issue:16, 2018
New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans.PloS one, , Volume: 12, Issue:3, 2017
Pathogenesis of Diet-induced Atopic Dermatitis in Hairless Mice.Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 137, Issue:1, 2017
Discovery of Novel Lipid Profiles in PCOS: Do Insulin and Androgen Oppositely Regulate Bioactive Lipid Production?The Journal of clinical endocrinology and metabolism, , 03-01, Volume: 102, Issue:3, 2017
Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice.The American journal of pathology, , Volume: 187, Issue:10, 2017
Hair Regenerative Mechanisms of Red Ginseng Oil and Its Major Components in the Testosterone-Induced Delay of Anagen Entry in C57BL/6 Mice.Molecules (Basel, Switzerland), , Sep-08, Volume: 22, Issue:9, 2017
Dietary effects of Raphanus sativus cv Sango on lipid and oxysterols accumulation in rat brain: A lipidomic study on a non-genetic obesity model.Chemistry and physics of lipids, , Volume: 207, Issue:Pt B, 2017
Linoleic acid metabolite leads to steroid resistant asthma features partially through NF-κB.Scientific reports, , 08-29, Volume: 7, Issue:1, 2017
Fatty Acids Induce Stemness in the Stromal Cells of a CT26 Mouse Tumor Model.Pathobiology : journal of immunopathology, molecular and cellular biology, , Volume: 84, Issue:5, 2017
NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.Nature, , Mar-10, Volume: 531, Issue:7593, 2016
LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease.Free radical research, , Volume: 49, Issue:5, 2015
Synergistic anti-tumor effects of melatonin and PUFAs from walnuts in a murine mammary adenocarcinoma model.Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 31, Issue:4, 2015
Dietary linoleic acid requirements in the presence of α-linolenic acid are lower than the historical 2 % of energy intake value, study in rats.The British journal of nutrition, , Apr-14, Volume: 113, Issue:7, 2015
Dietary flax oil rich in α-linolenic acid reduces renal disease and oxylipin abnormalities, including formation of docosahexaenoic acid derived oxylipins in the CD1-pcy/pcy mouse model of nephronophthisis.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 94, 2015
Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease.The American journal of pathology, , Volume: 185, Issue:1, 2015
Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice.Scientific reports, , Nov-30, Volume: 5, 2015
Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases.Nutrients, , May-21, Volume: 6, Issue:5, 2014
Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures.Turkish journal of medical sciences, , Volume: 44, Issue:4, 2014
Partial replacement of dietary linoleic acid with long chain n-3 polyunsaturated fatty acids protects against dextran sulfate sodium-induced colitis in rats.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 91, Issue:6, 2014
CD36- and GPR120-mediated Ca²⁺ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice.Gastroenterology, , Volume: 146, Issue:4, 2014
Deamidated lipocalin-2 induces endothelial dysfunction and hypertension in dietary obese mice.Journal of the American Heart Association, , Apr-10, Volume: 3, Issue:2, 2014
Mouse mammary gland is refractory to the effects of ethanol after natural lactation.Comparative medicine, , Volume: 63, Issue:1, 2013
Deficiency of n-6 polyunsaturated fatty acids is mainly responsible for atopic dermatitis-like pruritic skin inflammation in special diet-fed hairless mice.Experimental dermatology, , Volume: 22, Issue:4, 2013
UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats.Journal of bioenergetics and biomembranes, , Volume: 45, Issue:4, 2013
Linoleic acid metabolite drives severe asthma by causing airway epithelial injury.Scientific reports, , Volume: 3, 2013
Metabonomic profiling of TASTPM transgenic Alzheimer's disease mouse model.Journal of proteome research, , Dec-07, Volume: 11, Issue:12, 2012
Effective induction of oral anaphylaxis to ovalbumin in mice sensitized by feeding of the antigen with aid of oil emulsion and salicylate.The Journal of toxicological sciences, , Volume: 37, Issue:2, 2012
Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma.Hepatology (Baltimore, Md.), , Volume: 55, Issue:4, 2012
Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with α-linolenic acid in a rat model of inflammatory bowel disease.The British journal of nutrition, , Nov-14, Volume: 108, Issue:9, 2012
Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease.Toxicology letters, , Nov-30, Volume: 207, Issue:2, 2011
α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations.The British journal of nutrition, , Volume: 105, Issue:1, 2011
Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway.The Journal of investigative dermatology, , Volume: 131, Issue:3, 2011
Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status.Obesity (Silver Spring, Md.), , Volume: 19, Issue:2, 2011
[Studies on chemistry component and the biological activity of petroleum ether extraction from pre-and post-processed of Cornus officinalis].Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, , Volume: 33, Issue:2, 2010
Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation.Free radical biology & medicine, , May-15, Volume: 48, Issue:10, 2010
Linoleic acid supplementation results in increased arachidonic acid and eicosanoid production in CF airway cells and in cftr-/- transgenic mice.American journal of physiology. Lung cellular and molecular physiology, , Volume: 299, Issue:5, 2010
High-fat diets: details matter.Obesity (Silver Spring, Md.), , Volume: 17, Issue:7, 2009
Increased tissue arachidonic acid and reduced linoleic acid in a mouse model of cystic fibrosis are reversed by supplemental glycerophospholipids enriched in docosahexaenoic acid.The Journal of nutrition, , Volume: 139, Issue:12, 2009
Comparison of hypolipidemic activity of synthetic gallic acid-linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice.Chemico-biological interactions, , Jul-30, Volume: 174, Issue:2, 2008
Linoleate-rich high-fat diet decreases mortality in hypertensive heart failure rats compared with lard and low-fat diets.Hypertension (Dallas, Tex. : 1979), , Volume: 52, Issue:3, 2008
Topical omega-3 and omega-6 fatty acids for treatment of dry eye.Archives of ophthalmology (Chicago, Ill. : 1960), , Volume: 126, Issue:2, 2008
Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice.Investigative ophthalmology & visual science, , Volume: 48, Issue:9, 2007
COX-2 expression in cystic kidneys is dependent on dietary n-3 fatty acid composition.The Journal of nutritional biochemistry, , Volume: 18, Issue:12, 2007
Construction and functional analysis of fatty acid desaturase gene disruptants in Candida albicans.Microbiology (Reading, England), , Volume: 152, Issue:Pt 5, 2006
Linoleic acid derivative DCP-LA improves learning impairment in SAMP8.Neuroreport, , Jan-23, Volume: 17, Issue:1, 2006
A model for research on the blood-brain barrier disruption induced by unsaturated fatty acid emulsion.Investigative radiology, , Volume: 40, Issue:5, 2005
Putting cancer to sleep at night: the neuroendocrine/circadian melatonin signal.Endocrine, , Volume: 27, Issue:2, 2005
Dietary polyunsaturated fatty acids suppress acute hepatitis, alter gene expression and prolong survival of female Long-Evans Cinnamon rats, a model of Wilson disease.The Journal of nutritional biochemistry, , Volume: 15, Issue:5, 2004
Conjugated linoleic acid ameliorates viral infectivity in a pig model of virally induced immunosuppression.The Journal of nutrition, , Volume: 133, Issue:10, 2003
Might analysis, synthesis and metabolism of CLA contribute to explain the biological effects of CLA?European journal of medical research, , Aug-20, Volume: 8, Issue:8, 2003
Short-term administration of conjugated linoleic acid reduces liver triglyceride concentration and phosphatidate phosphohydrolase activity in OLETF rats.Journal of biochemistry and molecular biology, , Sep-30, Volume: 35, Issue:5, 2002
Colonic anti-inflammatory mechanisms of conjugated linoleic acid.Clinical nutrition (Edinburgh, Scotland), , Volume: 21, Issue:6, 2002
Effects of conjugated linoleic acid on adenoma formation in the ApcMin mouse.IARC scientific publications, , Volume: 156, 2002
Dietary supplementation with conjugated linoleic acid does not improve nutritional status of tumor-bearing rats.Research in nursing & health, , Volume: 25, Issue:1, 2002
Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action.Annual review of nutrition, , Volume: 22, 2002
Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action.The Journal of nutrition, , Volume: 132, Issue:10, 2002
Intestinal absorption and postabsorptive metabolism of linoleic acid in rats with short-term bile duct ligation.American journal of physiology. Gastrointestinal and liver physiology, , Volume: 279, Issue:6, 2000
Adaptation to chronic ethanol administration emphasized by fatty acid hydroxylations in rat liver and kidney microsomes.European journal of nutrition, , Volume: 39, Issue:6, 2000
A high sucrose, high linoleic acid diet potentiates hypertension in the Dahl salt sensitive rat.American journal of hypertension, , Volume: 12, Issue:2 Pt 1, 1999
Atherosclerosis and conjugated linoleic acid.The British journal of nutrition, , Volume: 81, Issue:3, 1999
Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model.European journal of pharmacology, , Jan-12, Volume: 341, Issue:2-3, 1998
Effect of dietary linoleate/alpha-linolenate balance on experimentally induced gastric injury in rats.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 59, Issue:5, 1998
Pathophysiologic studies of experimental chronic pancreatitis in rats induced by injection of zein-oleic acid-linoleic acid solution into the pancreatic duct.Pancreas, , Volume: 16, Issue:3, 1998
Essential fatty acid preparation improves biochemical and cognitive functions in experimental allergic encephalomyelitis rats.European journal of pharmacology, , Jun-05, Volume: 328, Issue:1, 1997
Effect of the dietary fat type on arterial thrombosis tendency: systematic studies with a rat model.Atherosclerosis, , Volume: 131, Issue:1, 1997
Modulation of adjuvant-induced arthritis by dietary arachidonic acid in essential fatty acid-deficient rats.Lipids, , Volume: 32, Issue:9, 1997
Comparative effects of linoleic acid and linoleic acid hydroperoxide on growth and morphology of bovine retinal pigment epithelial cells in vitro.Current eye research, , Volume: 15, Issue:5, 1996
Attenuation of experimental hypertension by dietary linoleic acid is model dependent.Journal of the American College of Nutrition, , Volume: 15, Issue:1, 1996
Developing Yoshida sarcoma does not influence the fatty acid composition of adipose tissues in the rat.Nutrition and cancer, , Volume: 24, Issue:1, 1995
Effect of N-3 polyunsaturated fatty acid supplemented diet on neutrophil-mediated ileal permeability and neutrophil function in the rat.Journal of the American College of Nutrition, , Volume: 14, Issue:3, 1995
Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness.The American journal of clinical nutrition, , Volume: 62, Issue:2, 1995
[The antiatherogenic action of plant oils with added omega-3 polyunsaturated fatty acids].Biulleten' eksperimental'noi biologii i meditsiny, , Volume: 116, Issue:10, 1993
Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats.Obesity research, , Volume: 1, Issue:2, 1993
Enhancement of aortic cholesterol deposition by dietary linoleic acid in cholesterol-fed mice: an animal model for primary screening of antiatherosclerotic agents.Journal of pharmacological and toxicological methods, , Volume: 30, Issue:3, 1993
Anorexic contribution to increased linoleate mobilization and oxidation in lymphoma-bearing mice.Lipids, , Volume: 27, Issue:2, 1992
Synergistic vascular toxicity and fatty acid anilides in the toxic oil syndrome.Journal of the American College of Cardiology, , Volume: 18, Issue:7, 1991
Dietary linoleic acid is required for development of experimentally induced alcoholic liver injury.Life sciences, , Volume: 44, Issue:3, 1989
[A rat model of chronic pancreatic insufficiency induced by injection of zein-oleic acid-linoleic acid solution into the pancreatic duct].Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, , Volume: 85, Issue:7, 1988
Cerulein induces hyperplasia of the pancreas in a rat model of chronic pancreatic insufficiency.Pancreas, , Volume: 2, Issue:2, 1987
Short-term dietary lipid manipulation does not affect survival in two models of murine sepsis.JPEN. Journal of parenteral and enteral nutrition, , Volume: 16, Issue:4
HPLC and GC-MS Analysis of Tunisian Peganum harmala Seeds Oil and Evaluation of Some Biological Activities.American journal of therapeutics, , Volume: 24, Issue:6
Antioxidant, antihemolytic and nephroprotective activity of aqueous extract of Diospyros lotus seeds.Acta poloniae pharmaceutica, , Volume: 69, Issue:4
Tumor targeting by arterial administration of lipids: rabbit model with VX2 carcinoma in the liver.Anticancer research, , Volume: 7, Issue:3 Pt B
Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice.Neoplasia (New York, N.Y.), , Volume: 6, Issue:6
Effect of a combination of medium chain triglycerides, linoleic acid, soy lecithin and vitamins A and E on wound healing in rats.Acta cirurgica brasileira, , Volume: 23, Issue:3
Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection.Frontiers in immunology, , Volume: 11, 2020
Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota?Antioxidants & redox signaling, , 01-10, Volume: 30, Issue:2, 2019
Oro-gustatory perception of dietary lipids and calcium signaling in taste bud cells are altered in nutritionally obesity-prone Psammomys obesus.PloS one, , Volume: 8, Issue:8, 2013
Molecular basis for maize as a risk factor for esophageal cancer in a South African population via a prostaglandin E2 positive feedback mechanism.Nutrition and cancer, , Volume: 63, Issue:5, 2011
Hepatic metabolism of glucose and linoleic acid varies in relation to susceptibility to fatty liver in ad libitum-fed Muscovy and Pekin ducks.The British journal of nutrition, , Volume: 101, Issue:4, 2009
Maize meal predisposes to endemic squamous cancer of the oesophagus in Africa: breakdown of esterified linoleic acid to the free form in stored meal leads to increased intragastric PGE2 production and a low-acid reflux.Medical hypotheses, , Volume: 67, Issue:6, 2006
Purification and properties of lipoxygenase from wheat seedlings infected by Fusarium graminearum and treated by salicylic acid.Ukrainian biochemical journal, , Volume: 88, Issue:6
Sodium oleate, arachidonate, and linoleate enhance fibrinogenolysis by Russell's viper venom proteinases and inhibit FXIIIa; a role for phospholipase AToxicon : official journal of the International Society on Toxinology, , Oct-30, Volume: 186, 2020
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Characterization of Natural Compounds as Inhibitors of NS1 Endonuclease from Canine Parvovirus Type 2.Journal of microbiology and biotechnology, , Jun-28, Volume: 33, Issue:6, 2023
Linoleic acid salt with ultrapure soft water as an antibacterial combination against dermato-pathogenic Staphylococcus spp.Journal of applied microbiology, , Volume: 120, Issue:2, 2016
Study of lipid in the ear canal in canine otitis externa with Malassezia pachydermatis.The Journal of veterinary medical science, , Volume: 62, Issue:11, 2000
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Linoleate produces remission in canine mycosis fungoides.Cancer letters, , May-30, Volume: 64, Issue:1, 1992
The benefit of a ceramide-linoleic acid-containing moisturizer as an adjunctive therapy for a set of xerotic dermatoses.Dermatologic therapy, , Volume: 32, Issue:4, 2019
Serum, cheek cell and breast milk fatty acid compositions in infants with atopic and non-atopic eczema.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , Volume: 36, Issue:2, 2006
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Exploring the effect of the Uyghur medicine Munziq Balgam on a collagen-induced arthritis rat model by UPLC-MS/MS-based metabolomics approach.Journal of ethnopharmacology, , Jun-28, Volume: 310, 2023
Anti-inflammatory and analgesic actions of bufotenine through inhibiting lipid metabolism pathway.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 140, 2021
A low ratio of n-6/n-3 polyunsaturated fatty acids suppresses matrix metalloproteinase 13 expression and reduces adjuvant-induced arthritis in rats.Nutrition research (New York, N.Y.), , Volume: 35, Issue:12, 2015
α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations.The British journal of nutrition, , Volume: 105, Issue:1, 2011
Antioxidant, anti-inflammatory, anti-nociceptive activities and composition of Lythrum salicaria L. extracts.Journal of ethnopharmacology, , Apr-04, Volume: 110, Issue:3, 2007
Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.The Journal of pharmacology and experimental therapeutics, , Volume: 287, Issue:1, 1998
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Molecular basis for maize as a risk factor for esophageal cancer in a South African population via a prostaglandin E2 positive feedback mechanism.Nutrition and cancer, , Volume: 63, Issue:5, 2011
Maize meal predisposes to endemic squamous cancer of the oesophagus in Africa: breakdown of esterified linoleic acid to the free form in stored meal leads to increased intragastric PGE2 production and a low-acid reflux.Medical hypotheses, , Volume: 67, Issue:6, 2006
Nutrient intake and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay.Nutrition and cancer, , Volume: 56, Issue:2, 2006
Maize meal, non-esterified linoleic acid, and endemic cancer of the esophagus--preliminary findings.Prostaglandins & other lipid mediators, , Volume: 57, Issue:2-3, 1999
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Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.Journal of medicinal chemistry, , 06-13, Volume: 62, Issue:11, 2019
Digital gene-expression profiling analysis of the fatty liver of Landes geese fed different supplemental oils.Gene, , Oct-05, Volume: 673, 2018
Inhibition of exendin-4-induced steatosis by protein kinase A in cultured HepG2 human hepatoma cells.In vitro cellular & developmental biology. Animal, , Volume: 53, Issue:8, 2017
New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans.PloS one, , Volume: 12, Issue:3, 2017
Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency.EMBO reports, , Volume: 15, Issue:1, 2014
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Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism.Hepatology (Baltimore, Md.), , Volume: 56, Issue:4, 2012
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Hepatic metabolism of glucose and linoleic acid varies in relation to susceptibility to fatty liver in ad libitum-fed Muscovy and Pekin ducks.The British journal of nutrition, , Volume: 101, Issue:4, 2009
Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver.Physiological genomics, , May-13, Volume: 37, Issue:3, 2009
Hepatomegaly induced by trans-10,cis-12 conjugated linoleic acid in adult hamsters fed an atherogenic diet is not associated with steatosis.Journal of the American College of Nutrition, , Volume: 28, Issue:1, 2009
High-fat diets: details matter.Obesity (Silver Spring, Md.), , Volume: 17, Issue:7, 2009
Comparison of hypolipidemic activity of synthetic gallic acid-linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice.Chemico-biological interactions, , Jul-30, Volume: 174, Issue:2, 2008
Is the hepatic metabolism of glucose and linoleic acid influenced by species in overfed ducks?Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, , Volume: 151, Issue:4, 2008
Dietary conjugated linoleic acid alleviates nonalcoholic fatty liver disease in Zucker (fa/fa) rats.The Journal of nutrition, , Volume: 135, Issue:1, 2005
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A method to fix lipids for staining fat embolism in paraffin sections.Histopathology, , Volume: 41, Issue:1, 2002
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GC-MS based comparative metabolomic analysis of human cancellous bone reveals the critical role of linoleic acid metabolism in femur head necrosis.Metabolomics : Official journal of the Metabolomic Society, , 09-30, Volume: 19, Issue:10, 2023
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Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection.Frontiers in immunology, , Volume: 11, 2020
PCTR1 ameliorates lipopolysaccharide-induced acute inflammation and multiple organ damage via regulation of linoleic acid metabolism by promoting FADS1/FASDS2/ELOV2 expression and reducing PLA2 expression.Laboratory investigation; a journal of technical methods and pathology, , Volume: 100, Issue:7, 2020
Diets with low n-6:n-3 PUFA ratio protects rats from fructose-induced dyslipidemia and associated hepatic changes: Comparison between 18:3 n-3 and long-chain n-3 PUFA.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 155, 2020
Spectrofluorometric Analysis of Autofluorescing Components of Crude Serum from a Rat Liver Model of Ischemia and Reperfusion.Molecules (Basel, Switzerland), , Mar-14, Volume: 25, Issue:6, 2020
Isotope-reinforced polyunsaturated fatty acids improve Parkinson's disease-like phenotype in rats overexpressing α-synuclein.Acta neuropathologica communications, , 12-11, Volume: 8, Issue:1, 2020
Interplay of Dietary Fatty Acids and Cholesterol Impacts Brain Mitochondria and Insulin Action.Nutrients, , May-23, Volume: 12, Issue:5, 2020
Proopiomelanocortin Processing in the Hypothalamus Is Directly Regulated by Saturated Fat: Implications for the Development of Obesity.Neuroendocrinology, , Volume: 110, Issue:1-2, 2020
Lipolysis modulates the biosynthesis of inflammatory lipid mediators derived from linoleic acid in adipose tissue of periparturient dairy cows.Journal of dairy science, , Volume: 103, Issue:2, 2020
The role of linoleic acid in asthma and inflammatory markers: a Mendelian randomization study.The American journal of clinical nutrition, , 09-01, Volume: 110, Issue:3, 2019
Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids.Nature communications, , 09-05, Volume: 10, Issue:1, 2019
Protective effect of linoleic acid against inflammatory reactions by mast cell via caspase-1 cascade pathways.Journal of food biochemistry, , Volume: 43, Issue:8, 2019
Inflammatory response to dietary linoleic acid depends on FADS1 genotype.The American journal of clinical nutrition, , 01-01, Volume: 109, Issue:1, 2019
Modification of gene expression in rat cardiomyocytes by linoleic and docosahexaenoic acids Canadian journal of physiology and pharmacology, , Volume: 97, Issue:4, 2019
Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 135, 2018
Digital gene-expression profiling analysis of the fatty liver of Landes geese fed different supplemental oils.Gene, , Oct-05, Volume: 673, 2018
The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain.Biochimica et biophysica acta. Molecular and cell biology of lipids, , Volume: 1863, Issue:7, 2018
Omega-6 fatty acids and inflammation.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 132, 2018
Supplemental feeding of a gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, alleviates spontaneous atopic dermatitis and modulates intestinal microbiota in NC/nga mice.International journal of food sciences and nutrition, , Volume: 68, Issue:8, 2017
Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung.Thorax, , Volume: 72, Issue:1, 2017
A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch.Science signaling, , Aug-22, Volume: 10, Issue:493, 2017
Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice.The American journal of pathology, , Volume: 187, Issue:10, 2017
Neither linoleic acid nor arachidonic acid promote white adipose tissue inflammation in Fads2-/- mice fed low fat diets.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 126, 2017
Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases.Nutrients, , Oct-25, Volume: 9, Issue:11, 2017
Beyond the classic eicosanoids: Peripherally-acting oxygenated metabolites of polyunsaturated fatty acids mediate pain associated with tissue injury and inflammation.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 111, 2016
Hydroxyoctadecadienoic acids: Oxidised derivatives of linoleic acid and their role in inflammation associated with metabolic syndrome and cancer.European journal of pharmacology, , Aug-15, Volume: 785, 2016
Pro-inflammatory chemokines CCL2, chemerin, IP-10 and RANTES in human serum during an oral lipid tolerance test.Cytokine, , Volume: 80, 2016
Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells.Biochemical and biophysical research communications, , Mar-18, Volume: 471, Issue:4, 2016
Whole-blood fatty acids and inflammation in European children: the IDEFICS Study.European journal of clinical nutrition, , Volume: 70, Issue:7, 2016
Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties.Diabetes, , Volume: 65, Issue:9, 2016
Australia's nutrition transition 1961-2009: a focus on fats.The British journal of nutrition, , Aug-14, Volume: 114, Issue:3, 2015
Three-dimensional spheroid cell model of in vitro adipocyte inflammation.Tissue engineering. Part A, , Volume: 21, Issue:11-12, 2015
Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease.The American journal of pathology, , Volume: 185, Issue:1, 2015
A High Linoleic Acid Diet does not Induce Inflammation in Mouse Liver or Adipose Tissue.Lipids, , Volume: 50, Issue:11, 2015
ω-6 (18:2) and ω-3 (18:3) fatty acids in reconstituted high-density lipoproteins show different functionality of anti-atherosclerotic properties and embryo toxicity.The Journal of nutritional biochemistry, , Volume: 26, Issue:12, 2015
Excessive dietary linoleic acid induces proinflammatory markers in rats.The Journal of nutritional biochemistry, , Volume: 26, Issue:12, 2015
Maternal supplementation with conjugated linoleic acid in the setting of diet-induced obesity normalises the inflammatory phenotype in mothers and reverses metabolic dysfunction and impaired insulin sensitivity in offspring.The Journal of nutritional biochemistry, , Volume: 26, Issue:12, 2015
Omega-3 PUFAs Lower the Propensity for Arachidonic Acid Cascade Overreactions.BioMed research international, , Volume: 2015, 2015
Serum fatty acid patterns, insulin sensitivity and the metabolic syndrome in individuals with chronic kidney disease.Journal of internal medicine, , Volume: 275, Issue:1, 2014
Lipid mediator profiles differ between lung compartments in asthmatic and healthy humans.The European respiratory journal, , Volume: 43, Issue:2, 2014
Associations of erythrocyte membrane fatty acids with the concentrations of C-reactive protein, interleukin 1 receptor antagonist and adiponectin in 1373 men.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 91, Issue:4, 2014
Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans.The Journal of biological chemistry, , Aug-08, Volume: 289, Issue:32, 2014
Linoleate appears to protect against palmitate-induced inflammation in Huh7 cells.Lipids in health and disease, , May-13, Volume: 13, 2014
Fat necrosis generates proinflammatory halogenated lipids during acute pancreatitis.Annals of surgery, , Volume: 257, Issue:5, 2013
Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon (Salmo salar L.) and mice, and induces weight gain and inflammation in mice.The British journal of nutrition, , Apr-28, Volume: 109, Issue:8, 2013
Effects of conjugated linoleic acid on growth, non-specific immunity, antioxidant capacity, lipid deposition and related gene expression in juvenile large yellow croaker (Larmichthys crocea) fed soyabean oil-based diets.The British journal of nutrition, , Volume: 110, Issue:7, 2013
n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis.The British journal of nutrition, , Nov-14, Volume: 110, Issue:9, 2013
Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases.Lipids in health and disease, , May-07, Volume: 12, 2013
Oxidized linoleic acid metabolite-cytochrome P450 system (OLAM-CYP) is active in biopsy samples from patients with inflammatory dental pain.Pain, , Volume: 154, Issue:11, 2013
Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization.Clinical and experimental immunology, , Volume: 174, Issue:3, 2013
Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins.The American journal of cardiology, , Dec-01, Volume: 112, Issue:11, 2013
Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice.Journal of lipid research, , Volume: 54, Issue:4, 2013
The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells.Nutritional neuroscience, , Volume: 16, Issue:1, 2013
Dietary factors associated with subclinical inflammation among girls.European journal of clinical nutrition, , Volume: 67, Issue:12, 2013
Effect of dietary linoleic acid on markers of inflammation in healthy persons: a systematic review of randomized controlled trials.Journal of the Academy of Nutrition and Dietetics, , Volume: 112, Issue:7, 2012
Cytochrome P450 mediated linoleic acid metabolism in peripheral inflammatory nociception.Pain, , Volume: 153, Issue:10, 2012
Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation.Pain, , Volume: 153, Issue:10, 2012
A.S.P.E.N. position paper: Clinical role for alternative intravenous fat emulsions.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, , Volume: 27, Issue:2, 2012
The role of Rho/Rho-kinase pathway in the expression of ICAM-1 by linoleic acid in human aortic endothelial cells.Inflammation, , Volume: 35, Issue:3, 2012
Conjugated linoleic acid isomers may diminish human macrophages adhesion to endothelial surface.International journal of food sciences and nutrition, , Volume: 63, Issue:1, 2012
Obesity modifies the association between plasma phospholipid polyunsaturated fatty acids and markers of inflammation: the Multi-Ethnic Study of Atherosclerosis.International journal of obesity (2005), , Volume: 36, Issue:6, 2012
The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain.Molecular pain, , Sep-24, Volume: 8, 2012
Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD.The Journal of nutritional biochemistry, , Volume: 23, Issue:7, 2012
Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status.Obesity (Silver Spring, Md.), , Volume: 19, Issue:2, 2011
α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations.The British journal of nutrition, , Volume: 105, Issue:1, 2011
Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response.Bioorganic & medicinal chemistry, , Oct-01, Volume: 19, Issue:19, 2011
New Cholesterol Guidelines for Longevity (2010).World review of nutrition and dietetics, , Volume: 102, 2011
Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation.Free radical biology & medicine, , May-15, Volume: 48, Issue:10, 2010
Linoleic acid supplementation results in increased arachidonic acid and eicosanoid production in CF airway cells and in cftr-/- transgenic mice.American journal of physiology. Lung cellular and molecular physiology, , Volume: 299, Issue:5, 2010
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Fatty acid supplements improve respiratory, inflammatory and nutritional parameters in adults with cystic fibrosis.Archivos de bronconeumologia, , Volume: 46, Issue:2, 2010
Reduced ex vivo interleukin-6 production by dietary fish oil is not modified by linoleic acid intake in healthy men.The Journal of nutrition, , Volume: 139, Issue:7, 2009
Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men.Nutrition research (New York, N.Y.), , Volume: 29, Issue:6, 2009
In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation.The British journal of nutrition, , Volume: 102, Issue:4, 2009
Evolutionary aspects of the dietary omega-6:omega-3 fatty acid ratio: medical implications.World review of nutrition and dietetics, , Volume: 100, 2009
Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms.Atherosclerosis, , Volume: 199, Issue:2, 2008
FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease.The American journal of clinical nutrition, , Volume: 88, Issue:4, 2008
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Linoleic acid and the regulation of glucose homeostasis: A review of the evidence.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 175, 2021
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A Comprehensive Analysis of Microflora and Metabolites in the Development of Ulcerative Colitis into Colorectal Cancer Based on the Lung-Gut Correlation Theory.Molecules (Basel, Switzerland), , Sep-08, Volume: 27, Issue:18, 2022
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Linoleic acid and colorectal cancer cell growth suppression: is the deregulation of mitochondrial survivin the key factor?International journal of colorectal disease, , Volume: 27, Issue:10, 2012
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Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease.Nutrition research (New York, N.Y.), , Volume: 28, Issue:4, 2008
Short-term duodenal seal oil administration normalised n-6 to n-3 fatty acid ratio in rectal mucosa and ameliorated bodily pain in patients with inflammatory bowel disease.Lipids in health and disease, , Mar-20, Volume: 5, 2006
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Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice.Gut microbes, , Volume: 15, Issue:1
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Effect of dietary linoleate/alpha-linolenate balance on experimentally induced gastric injury in rats.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 59, Issue:5, 1998
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Linoleic Acid Metabolite DiHOME Decreases Post-ischemic Cardiac Recovery in Murine Hearts.Cardiovascular toxicology, , Volume: 19, Issue:4, 2019
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Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats.International journal of food sciences and nutrition, , Volume: 64, Issue:5, 2013
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The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects.International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, , Volume: 27, Issue:7, 2003
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The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation.The Journal of clinical endocrinology and metabolism, , Volume: 86, Issue:1, 2001
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Dietary conjugated linoleic acid protects against end stage disease of systemic lupus erythematosus in the NZB/W F1 mouse.Immunopharmacology and immunotoxicology, , Volume: 22, Issue:3, 2000
Magnetic resonance imaging-based balance analysis of linoleate utilization during weight loss in obese humans.Lipids, , Volume: 34 Suppl, 1999
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Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation.Proceedings of the National Academy of Sciences of the United States of America, , Jun-01, Volume: 90, Issue:11, 1993
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Unsaturated fatty acids are required for continuous proliferation of transformed androgen-dependent cells by fibroblast growth factor family proteins.Cancer research, , Dec-15, Volume: 54, Issue:24, 1994
PHOSPHORUS METABOLISM IN VIRAL-INDUCED NEOPLASIA. II. IN VIVO AND IN VITRO STUDIES OF THE MILK AND MAMMARY GLAND LIPIDES OF STRAINS OF MICE SUSCEPTIBLE TO THE MAMMARY TUMOR VIRUS.Canadian journal of biochemistry, , Volume: 43, 1965
Antibiotics-free nanoparticles eradicate Helicobacter pylori biofilms and intracellular bacteria.Journal of controlled release : official journal of the Controlled Release Society, , Volume: 348, 2022
Non-genetic biomarkers and colorectal cancer risk: Umbrella review and evidence triangulation.Cancer medicine, , Volume: 9, Issue:13, 2020
Steroids mediate resistance to the bactericidal effect of phosphatidylcholines against Helicobacter pylori.FEMS microbiology letters, , Volume: 301, Issue:1, 2009
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Controversies in the Use of Lipid Injectable Emulsion in Hospitalized Patients.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, , Volume: 33, Issue:3, 2018
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Gestational diabetes mellitus decreased umbilical cord blood polyunsaturated fatty acids: a meta-analysis of observational studies.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 171, 2021
Gestational diabetes mellitus prediction? A unique fatty acid profile study.Nutrition & diabetes, , 09-30, Volume: 10, Issue:1, 2020
Circulating Linoleic Acid is Associated with Improved Glucose Tolerance in Women after Gestational Diabetes.Nutrients, , Nov-02, Volume: 10, Issue:11, 2018
Lipid peroxides, nitric oxide and essential fatty acids in patients with Plasmodium falciparum malaria.Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 61, Issue:4, 1999
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Metabolomic Signature of Endometrial Cancer.Journal of proteome research, , 02-02, Volume: 17, Issue:2, 2018
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Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry).Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 11, Issue:1, 2004
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Dietary α-linolenic acid, linoleic acid, and n-3 long-chain PUFA and risk of ischemic heart disease.The American journal of clinical nutrition, , Volume: 94, Issue:4, 2011
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Evaluation of oxidative stress in diabetics with or without vascular complications.The Journal of the Association of Physicians of India, , Volume: 43, Issue:1, 1995
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Safety/Toxicity (69)
| Article | Year |
|---|
Circulating microRNAs as novel biomarkers for measuring the potency of ginger extract against cyclophosphamide toxicity in rat renal tissues: molecular and histopathological study.
European review for medical and pharmacological sciences, , Volume: 27, Issue:22 | 2023 |
In Vitro Cytotoxicity and Cytokine Production by Lipid-Substituted Low Molecular Weight Branched PEIs Used for Gene Delivery.
Acta biomaterialia, , Volume: 148 | 2022 |
Efficacy and safety of a topical moisturizer containing linoleic acid and ceramide for mild-to-moderate psoriasis vulgaris: A multicenter randomized controlled trial.
Dermatologic therapy, , Volume: 33, Issue:6 | 2020 |
Linoleic acid promotes testosterone production by activating Leydig cell GPR120/ ERK pathway and restores BPA-impaired testicular toxicity.
Steroids, , Volume: 163 | 2020 |
Photothermal-pH-hypoxia responsive multifunctional nanoplatform for cancer photo-chemo therapy with negligible skin phototoxicity.
Biomaterials, , Volume: 221 | 2019 |
How to safeguard an appropriate "all trans retinoic acid" concentration to keep cell division on track: Exploring therapeutic hotspots from metabolomics.
Medical hypotheses, , Volume: 121 | 2018 |
Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles.
Bioorganic & medicinal chemistry, , 12-01, Volume: 26, Issue:22 | 2018 |
Assessment of antimicrobial, antioxidant and cytotoxicity properties of Camellia sinensis L.
Pakistan journal of pharmaceutical sciences, , Volume: 31, Issue:4 | 2018 |
Antimicrobial, antioxidant, cytotoxicity and LC-MS analyses of Aerva javanica: an ethnomedicinally important plant.
Journal of biological regulators and homeostatic agents, , Volume: 31, Issue:4 | |
ALA/LA ameliorates glucose toxicity on HK-2 cells by attenuating oxidative stress and apoptosis through the ROS/p38/TGF-β
Lipids in health and disease, , Nov-16, Volume: 16, Issue:1 | 2017 |
Fabrication of size-controlled linoleic acid particles and evaluation of their in-vitro lipotoxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 100 | 2017 |
Photosensitized rose Bengal-induced phototoxicity on human melanoma cell line under natural sunlight exposure.
Journal of photochemistry and photobiology. B, Biology, , Volume: 156 | 2016 |
ω-6 (18:2) and ω-3 (18:3) fatty acids in reconstituted high-density lipoproteins show different functionality of anti-atherosclerotic properties and embryo toxicity.
The Journal of nutritional biochemistry, , Volume: 26, Issue:12 | 2015 |
Protective effect of arachidonic acid and linoleic acid on 1-methyl-4-phenylpyridinium-induced toxicity in PC12 cells.
Lipids in health and disease, , Dec-19, Volume: 13 | 2014 |
Complexes between linoleate and native or aggregated β-lactoglobulin: interaction parameters and in vitro cytotoxic effect.
Food chemistry, , Dec-01, Volume: 141, Issue:3 | 2013 |
Fatty acid profile, oxidative stability and toxicological safety of bayberry kernel oil.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 60 | 2013 |
Novel surfactants with diglutamic acid polar head group: drug solubilization and toxicity studies.
Pharmaceutical research, , Volume: 29, Issue:7 | 2012 |
The saturated fatty acid palmitate induces human monocytic cell toxicity toward neuronal cells: exploring a possible link between obesity-related metabolic impairments and neuroinflammation.
Journal of Alzheimer's disease : JAD, , Volume: 30 Suppl 2 | 2012 |
Cell density-dependent linoleic acid toxicity to Saccharomyces cerevisiae.
FEMS yeast research, , Volume: 11, Issue:5 | 2011 |
Decreasing the oxidative potential of TiO(2) nanoparticles through modification of the surface with carbon: a new strategy for the production of safe UV filters.
Chemical communications (Cambridge, England), , Nov-28, Volume: 46, Issue:44 | 2010 |
Toxicity of unsaturated fatty acids to the biohydrogenating ruminal bacterium, Butyrivibrio fibrisolvens.
BMC microbiology, , Feb-18, Volume: 10 | 2010 |
Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs).
Cell biochemistry and function, , Volume: 27, Issue:5 | 2009 |
Cytotoxicity of oxidised lipids in cultured colonal human intestinal cancer cells (caco-2 cells).
Toxicology letters, , Aug-28, Volume: 180, Issue:3 | 2008 |
Tolerability and safety of olive oil-based lipid emulsion in critically ill neonates: a blinded randomized trial.
Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 24, Issue:11-12 | |
In vitro phototoxicity of dihydropyridine derivatives: a photochemical and photobiological study.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, , Mar-03, Volume: 33, Issue:3 | 2008 |
Lipotoxic effects of triacylglycerols in J774.2 macrophages.
Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 24, Issue:2 | 2008 |
Photodegradation and in vitro phototoxicity of aceclofenac.
Die Pharmazie, , Volume: 62, Issue:5 | 2007 |
Evidence that 4-aminobiphenyl, benzidine, and benzidine congeners produce genotoxicity through reactive oxygen species.
Environmental and molecular mutagenesis, , Volume: 48, Issue:5 | 2007 |
Metabolism of polyunsaturated fatty acids and their toxicity to the microflora of the rumen.
Antonie van Leeuwenhoek, , Volume: 91, Issue:4 | 2007 |
Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells.
Toxicology in vitro : an international journal published in association with BIBRA, , Volume: 20, Issue:7 | 2006 |
Microbially safe utilization of non-inactivated oats (Avena sativa L.) for production of conjugated linoleic acid.
Journal of agricultural and food chemistry, , Feb-08, Volume: 54, Issue:3 | 2006 |
Comparative toxicity of oleic and linoleic acid on human lymphocytes.
Life sciences, , Feb-23, Volume: 78, Issue:13 | 2006 |
Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro.
Diabetologia, , Volume: 48, Issue:9 | 2005 |
Comparative toxicity of oleic acid and linoleic acid on Raji cells.
Nutrition (Burbank, Los Angeles County, Calif.), , Volume: 21, Issue:3 | 2005 |
Photochemistry and phototoxicity of fluocinolone 16,17-acetonide.
Photochemistry and photobiology, , Volume: 81, Issue:2 | |
Comparative toxicity of oleic acid and linoleic acid on Jurkat cells.
Clinical nutrition (Edinburgh, Scotland), , Volume: 23, Issue:4 | 2004 |
A subchronic 90-day oral rat toxicity study and in vitro genotoxicity studies with a conjugated linoleic acid product.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 41, Issue:12 | 2003 |
Final report on the amended safety assessment of diisopropyl dimer dilinoleate, dicetearyl dimer dilinoleate, diisostearyl dimer dilinoleate, dioctyl dimer dilinoleate, dioctyldodecyl dimer dilinoleate, and ditridecyl dimer dilinoleate.
International journal of toxicology, , Volume: 22 Suppl 2 | 2003 |
Inhibition of excitotoxicity in cultured rat cortical neurons by a mixture of conjugated linoleic acid isomers.
Pharmacological research, , Volume: 47, Issue:4 | 2003 |
Potent cytotoxic effect of the trans10, cis12 isomer of conjugated linoleic acid on rat hepatoma dRLh-84 cells.
Cancer letters, , Dec-15, Volume: 188, Issue:1-2 | 2002 |
Studies on the photostability and phototoxicity of aloe-emodin, emodin and rhein.
Die Pharmazie, , Volume: 57, Issue:6 | 2002 |
Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma.
Diabetes research and clinical practice, , Volume: 56, Issue:2 | 2002 |
Modification of doxorubicin-induced cardiotoxicity: effect of essential fatty acids and ICRF-187 (dexrazoxane).
European journal of cancer (Oxford, England : 1990), , Volume: 37, Issue:11 | 2001 |
Defining mechanisms of toxicity for linoleic acid monoepoxides and diols in Sf-21 cells.
Chemical research in toxicology, , Volume: 14, Issue:4 | 2001 |
The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells.
Toxicology and applied pharmacology, , Mar-15, Volume: 171, Issue:3 | 2001 |
Olive oil prevents the adverse effects of dietary conjugated linoleic acid on chick hatchability and egg quality.
The Journal of nutrition, , Volume: 131, Issue:3 | 2001 |
Studies on the in vitro phototoxicity of the antidiabetes drug glipizide.
In vitro & molecular toxicology, ,Spring, Volume: 13, Issue:1 | 2000 |
Linoleic acid cytotoxicity to bovine lens epithelial cells: influence of albumin on linoleic acid uptake and cytotoxicity.
Ophthalmic research, , Volume: 32, Issue:2-3 | |
Glutathione (GSH) and the toxicity of oxidised low-density lipoprotein to human monocyte-macrophages.
Free radical research, , Volume: 30, Issue:1 | 1999 |
Modulation of metal-induced cytotoxicity by maillard reaction products isolated from coffee brew.
Journal of toxicology and environmental health. Part A, , Sep-25, Volume: 55, Issue:2 | 1998 |
Influence of altered plasma membrane fatty acid composition on cesium transport characteristics and toxicity in Saccharomyces cerevisiae.
Canadian journal of microbiology, , Volume: 43, Issue:10 | 1997 |
Improvement of the pulmonary absorption of (Asu1,7)-eel calcitonin by various absorption enhancers and their pulmonary toxicity in rats.
Journal of pharmaceutical sciences, , Volume: 86, Issue:10 | 1997 |
Cytotoxicity of linoleic acid diols to renal proximal tubular cells.
Toxicology and applied pharmacology, , Volume: 146, Issue:1 | 1997 |
Oleic acid incorporation protects cultured hamster fibroblasts from oxygen-induced cytotoxicity.
The Journal of nutrition, , Volume: 126, Issue:12 | 1996 |
Copper toxicity towards Saccharomyces cerevisiae: dependence on plasma membrane fatty acid composition.
Applied and environmental microbiology, , Volume: 62, Issue:11 | 1996 |
Cytotoxicity of phosphatidylcholine hydroperoxides is exerted through decomposition of fatty acid hydroperoxide moiety.
Free radical biology & medicine, , Volume: 21, Issue:2 | 1996 |
Plasma fatty acid responses, metabolic effects, and safety of microalgal and fungal oils rich in arachidonic and docosahexaenoic acids in healthy adults.
The American journal of clinical nutrition, , Volume: 64, Issue:2 | 1996 |
Essential fatty acid deficiency in cultured human keratinocytes attenuates toxicity due to lipid peroxidation.
Toxicology and applied pharmacology, , Volume: 120, Issue:1 | 1993 |
Dietary n-3 fatty acids alter murine peritoneal macrophage cytotoxicity.
Annals of nutrition & metabolism, , Volume: 37, Issue:3 | 1993 |
Reduced cytotoxicity of a root canal sealer through eugenol substitution.
Journal of endodontics, , Volume: 19, Issue:11 | 1993 |
An incident of elevated levels of unsaturated free fatty acids in mussels from Nova Scotia and their toxic effect in mice after intraperitoneal injection.
Natural toxins, , Volume: 2, Issue:5 | 1994 |
Phospholipid hydrolysis of mildly oxidized LDL reduces their cytotoxicity to cultured endothelial cells. Potential protective role against atherogenesis.
Biochimica et biophysica acta, , Jun-06, Volume: 1256, Issue:3 | 1995 |
Hematopoietic toxicity of linoleic acid anilide: importance of aniline.
Fundamental and applied toxicology : official journal of the Society of Toxicology, , Volume: 25, Issue:2 | 1995 |
Treatment of acute lithium toxicity.
Veterinary and human toxicology, , Volume: 26, Issue:1 | 1984 |
Metabolic fate of liposomal phosphatidylinositol in murine tumor cells: implications for the mechanism of tumor cell cytotoxicity.
Cancer research, , Volume: 45, Issue:10 | 1985 |
Antitumor activity of D-mannosamine in vitro: cytotoxic effect produced by mannosamine in combination with free fatty acids on human leukemia T-cell lines.
Japanese journal of clinical oncology, , Volume: 15, Issue:3 | 1985 |
Synergistic vascular toxicity and fatty acid anilides in the toxic oil syndrome.
Journal of the American College of Cardiology, , Volume: 18, Issue:7 | 1991 |
Cytotoxicity of fatty acid oxygenase activation in rat basophilic leukemia cells.
Clinical immunology and immunopathology, , Volume: 62, Issue:1 Pt 1 | 1992 |
The effect of monosaturated and polyunsaturated fatty acids on oxygen toxicity in cultured cells.
Pediatric research, , Volume: 32, Issue:3 | 1992 |
Long-term Use (20)
| Article | Year |
|---|
Linoleic Acid in Adipose Tissue and Development of Ischemic Stroke: A Danish Case-Cohort Study.
Journal of the American Heart Association, , 06-26, Volume: 7, Issue:13 | 2018 |
Essential Fatty Acids Linoleic Acid and α-Linolenic Acid Sex-Dependently Regulate Glucose Homeostasis in Obesity.
Molecular nutrition & food research, , Volume: 62, Issue:17 | 2018 |
Serum Trans Fatty Acids Are Not Associated with Weight Gain or Linear Growth in School-Age Children.
The Journal of nutrition, , Volume: 145, Issue:9 | 2015 |
The change in low-density lipoprotein cholesterol concentration is positively related to plasma docosahexaenoic acid but not eicosapentaenoic acid.
Journal of atherosclerosis and thrombosis, , Volume: 19, Issue:7 | 2012 |
Dietary olive oil prevents carbon tetrachloride-induced hepatic fibrosis in mice.
Journal of gastroenterology, , Volume: 44, Issue:9 | 2009 |
Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat.
Psychopharmacology, , Volume: 182, Issue:1 | 2005 |
Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage.
Journal of the American Society of Nephrology : JASN, , Volume: 15, Issue:5 | 2004 |
Adipose tissue biomarkers of fatty acid intake.
The American journal of clinical nutrition, , Volume: 76, Issue:4 | 2002 |
Increased energy metabolism and suppressed body fat accumulation in mice by a low concentration of conjugated linoleic acid.
Bioscience, biotechnology, and biochemistry, , Volume: 65, Issue:10 | 2001 |
Polyunsaturated fatty acid supply with human milk. Physiological aspects and in vivo studies of metabolism.
Advances in experimental medicine and biology, , Volume: 478 | 2000 |
Diet-induced change in fatty acid composition of plasma triacylglycerols is not associated with change in glucagon-like peptide 1 or insulin sensitivity in people with type 2 diabetes.
The American journal of clinical nutrition, , Volume: 72, Issue:5 | 2000 |
Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis.
Cancer letters, , Sep-01, Volume: 143, Issue:2 | 1999 |
Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time-course analysis.
Neurochemical research, , Volume: 23, Issue:5 | 1998 |
Differential and interactive effects of calcium channel blockers and cholesterol content of the diet on jejunal uptake of lipids in rabbits.
Lipids, , Volume: 29, Issue:4 | 1994 |
Swimming endurance capacity of mice is increased by chronic consumption of medium-chain triglycerides.
The Journal of nutrition, , Volume: 125, Issue:3 | 1995 |
Ethanol, essential fatty acids and prostaglandins.
Pharmacology, biochemistry, and behavior, , Volume: 18 Suppl 1 | 1983 |
Modulation of rat gastric mucosal prostaglandin E2 release by dietary linoleic acid: effects on gastric acid secretion and stress-induced mucosal damage.
Gastroenterology, , Volume: 95, Issue:1 | 1988 |
Inducing effects of chronic administration of isoproterenol on 1-acyl-sn-glycero-3-phosphate and 1-acyl-sn-glycero-3-phosphocholine acyltransferases in rat parotid salivary gland.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, , Volume: 90, Issue:2 | 1988 |
[Changes in the free fatty acid composition of rat salivary glands induced by chronic administration of isoproterenol].
Gifu Shika Gakkai zasshi = The Journal of Gifu Dental Society, , Volume: 17, Issue:2 | 1990 |
The effects of chronic administration of ethanol on synaptosomal fatty acid composition: modulation by oil enriched with gamma-linolenic acid.
Alcohol and alcoholism (Oxford, Oxfordshire), , Volume: 27, Issue:1 | 1992 |
Pharmacokinetics (10)
| Article | Year |
|---|
Nanoparticulate tablet dosage form of lisofylline-linoleic acid conjugate for type 1 diabetes: in situ single-pass intestinal perfusion (SPIP) studies and pharmacokinetics in rat.
AAPS PharmSciTech, , Mar-24, Volume: 22, Issue:3 | 2021 |
Plasma and Red Blood Cell Membrane Accretion and Pharmacokinetics of RT001 (bis-Allylic 11,11-D2-Linoleic Acid Ethyl Ester) during Long Term Dosing in Patients.
Journal of pharmaceutical sciences, , Volume: 109, Issue:11 | 2020 |
Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles.
Bioorganic & medicinal chemistry, , 12-01, Volume: 26, Issue:22 | 2018 |
Pharmacokinetics of formulated tenoxicam transdermal delivery systems.
The Journal of pharmacy and pharmacology, , Volume: 60, Issue:1 | 2008 |
Mechanism of insulin-stimulated clearance of plasma nonesterified fatty acids in humans.
American journal of physiology. Endocrinology and metabolism, , Volume: 292, Issue:3 | 2007 |
Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, , Volume: 241, Issue:7 | 2003 |
Does the rate of fat deposition influence the pharmacokinetic disposition of subcutaneously administered moxidectin and ivermectin in pigs?
Journal of veterinary pharmacology and therapeutics, , Volume: 25, Issue:5 | 2002 |
A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints.
Annals of oncology : official journal of the European Society for Medical Oncology, , Volume: 11, Issue:9 | 2000 |
Increased mean platelet volume after oestrogen replacement therapy.
Annals of clinical biochemistry, , Volume: 33 ( Pt 6) | 1996 |
Plasma clearance and hepatic utilization of stearic, myristic and linoleic acids introduced via chylomicrons in rats.
Lipids, , Volume: 28, Issue:8 | 1993 |
Bioavailability (38)
| Article | Year |
|---|
The activities and mechanisms of intestinal microbiota metabolites of TCM herbal ingredients could be illustrated by a strategy integrating spectrum-effects, network pharmacology, metabolomics and molecular docking analysis: Platycodin D as an example.
Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 115 | 2023 |
Improving cellular uptake and bioavailability of periplocymarin-linoleic acid prodrug by combining PEGylated liposome.
Drug delivery, , Volume: 29, Issue:1 | 2022 |
Bioavailability and biotransformation of linolenic acid from basil seed oil as a novel source of omega-3 fatty acids tested on a rat experimental model.
Food & function, , Jul-18, Volume: 13, Issue:14 | 2022 |
Adverse effects of linoleic acid: Influence of lipid oxidation on lymphatic transport of citrus flavonoid and enterocyte morphology.
Food chemistry, , Feb-01, Volume: 369 | 2022 |
Natural sesame oil is superior to pre-digested lipid formulations and purified triglycerides in promoting the intestinal lymphatic transport and systemic bioavailability of cannabidiol.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 162 | 2021 |
Linoleic acid-derived 13-hydroxyoctadecadienoic acid is absorbed and incorporated into rat tissues.
Biochimica et biophysica acta. Molecular and cell biology of lipids, , Volume: 1866, Issue:3 | 2021 |
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology, , Volume: 96, Issue:5 | 2019 |
Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.
Journal of medicinal chemistry, , 06-13, Volume: 62, Issue:11 | 2019 |
Self-assembling lisofylline-fatty acid conjugate for effective treatment of diabetes mellitus.
Nanomedicine : nanotechnology, biology, and medicine, , Volume: 15, Issue:1 | 2019 |
Quantitative Prediction of Oral Bioavailability of a Lipophilic Antineoplastic Drug Bexarotene Administered in Lipidic Formulation Using a Combined In Vitro Lipolysis/Microsomal Metabolism Approach.
Journal of pharmaceutical sciences, , Volume: 108, Issue:2 | 2019 |
Linoleic acid reduces vascular reactivity and improves the vascular dysfunction of the small mesentery in hypertension.
The Journal of nutritional biochemistry, , Volume: 62 | 2018 |
Therapeutic efficacy of lipid emulsions of docetaxel-linoleic acid conjugate in breast cancer.
International journal of pharmaceutics, , Jul-30, Volume: 546, Issue:1-2 | 2018 |
Using linoleic acid embedded cellulose acetate membranes to in situ monitor polycyclic aromatic hydrocarbons in lakes and predict their bioavailability to submerged macrophytes.
Environmental science & technology, , May-19, Volume: 49, Issue:10 | 2015 |
In vitro assessment of antioxidant activity of tyrosol, resveratrol and their acetylated derivatives.
Food chemistry, , Jun-15, Volume: 177 | 2015 |
Effects of lipid vehicle and P-glycoprotein inhibition on the mesenteric lymphatic transport of paclitaxel in unconscious, lymph duct-cannulated rats.
Drug delivery, , Volume: 23, Issue:1 | 2016 |
Anticancer efficacy of a novel propofol-linoleic acid-loaded escheriosomal formulation against murine hepatocellular carcinoma.
Nanomedicine (London, England), , Volume: 8, Issue:8 | 2013 |
Species differences in toxicokinetic parameters of glycidol after a single dose of glycidol or glycidol linoleate in rats and monkeys.
The Journal of toxicological sciences, , Volume: 37, Issue:4 | 2012 |
Enhanced anticancer activity of gemcitabine coupling with conjugated linoleic acid against human breast cancer in vitro and in vivo.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, , Volume: 82, Issue:2 | 2012 |
Long-chain polyunsaturated fatty acids in inborn errors of metabolism.
Nutrients, , Volume: 2, Issue:9 | 2010 |
Fatty acids and vitamins generate singlet oxygen under UVB irradiation.
Experimental dermatology, , Volume: 21, Issue:2 | 2012 |
Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids.
Biochimica et biophysica acta, , Volume: 1814, Issue:1 | 2011 |
Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta.
Nutrition, metabolism, and cardiovascular diseases : NMCD, , Volume: 21, Issue:3 | 2011 |
Development and biopharmaceutical evaluation of quinupramine-EVA matrix containing penetration enhancer for the enhanced transdermal absorption in rats.
Pharmaceutical development and technology, , Volume: 12, Issue:5 | 2007 |
Impact of foods nutritionally enhanced through biotechnology in alleviating malnutrition in developing countries.
Journal of AOAC International, , Volume: 90, Issue:5 | |
Coping strategies and nutritional health in rural Niger: recommendations for consumption of wild plant foods in the Sahel.
International journal of food sciences and nutrition, , Volume: 57, Issue:5-6 | |
Down-regulation of PPARgamma2-induced adipogenesis by PEGylated conjugated linoleic acid as the pro-drug: Attenuation of lipid accumulation and reduction of apoptosis.
Archives of biochemistry and biophysics, , Dec-01, Volume: 456, Issue:1 | 2006 |
Micellar oleic and eicosapentaenoic acid but not linoleic acid influences the beta-carotene uptake and its cleavage into retinol in rats.
Molecular and cellular biochemistry, , Volume: 288, Issue:1-2 | 2006 |
Inhibition of the metmyoglobin-induced peroxidation of linoleic acid by dietary antioxidants: Action in the aqueous vs. lipid phase.
Free radical research, , Volume: 39, Issue:5 | 2005 |
Effect of dietary conjugated linoleic acid (CLA) on metabolism of isotope-labeled oleic, linoleic, and CLA isomers in women.
Lipids, , Volume: 37, Issue:8 | 2002 |
The effects of intestinal infusion of long-chain fatty acids on food intake in humans.
Gastroenterology, , Volume: 119, Issue:4 | 2000 |
Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid.
Journal of pharmaceutical sciences, , Volume: 89, Issue:10 | 2000 |
15-Lipoxygenase catalytically consumes nitric oxide and impairs activation of guanylate cyclase.
The Journal of biological chemistry, , Jul-16, Volume: 274, Issue:29 | 1999 |
Assessments on the digestibility of oxidized compounds from [1-14C] linoleic acid using a combination of chromatographic techniques.
Journal of chromatography. B, Biomedical applications, , Jan-12, Volume: 675, Issue:1 | 1996 |
Selenium status of vegeterians, nonvegetarians, and hormone-dependent cancer subjects.
The American journal of clinical nutrition, , Volume: 37, Issue:1 | 1983 |
Whole body oxidation of dietary fatty acids: implications for energy utilization.
The American journal of clinical nutrition, , Volume: 42, Issue:5 | 1985 |
Effect of free fatty acids on the bioavailability of plasma testosterone and dihydrotestosterone.
Journal of steroid biochemistry, , Volume: 29, Issue:3 | 1988 |
[Skin changes, pathophysiology and therapy in deficiency of essential fatty acids].
Zeitschrift fur Hautkrankheiten, , Apr-15, Volume: 63, Issue:4 | 1988 |
Polyunsaturated fatty acids decrease the apparent affinity of vitamin D metabolites for human vitamin D-binding protein.
The Journal of steroid biochemistry and molecular biology, , Volume: 42, Issue:8 | 1992 |
Dosage (76)
| Article | Year |
|---|
Linoleic acid ameliorates intestinal mucosal barrier injury in early weaned pigeon squabs (Columba livia).
Journal of animal science, , Jan-03, Volume: 101 | 2023 |
Exploring the effect of the Uyghur medicine Munziq Balgam on a collagen-induced arthritis rat model by UPLC-MS/MS-based metabolomics approach.
Journal of ethnopharmacology, , Jun-28, Volume: 310 | 2023 |
Effect of Short-Chain Fatty Acids and Polyunsaturated Fatty Acids on Metabolites in H460 Lung Cancer Cells.
Molecules (Basel, Switzerland), , Mar-03, Volume: 28, Issue:5 | 2023 |
Double blind trial of a deuterated form of linoleic acid (RT001) in Friedreich ataxia.
Journal of neurology, , Volume: 270, Issue:3 | 2023 |
Fabrication, characterization, and purification of nutraceutical diacylglycerol components from Camellia oil.
Journal of food science, , Volume: 87, Issue:9 | 2022 |
Nanoparticulate tablet dosage form of lisofylline-linoleic acid conjugate for type 1 diabetes: in situ single-pass intestinal perfusion (SPIP) studies and pharmacokinetics in rat.
AAPS PharmSciTech, , Mar-24, Volume: 22, Issue:3 | 2021 |
Plasma and Red Blood Cell Membrane Accretion and Pharmacokinetics of RT001 (bis-Allylic 11,11-D2-Linoleic Acid Ethyl Ester) during Long Term Dosing in Patients.
Journal of pharmaceutical sciences, , Volume: 109, Issue:11 | 2020 |
N-6 Polyunsaturated Fatty Acids and Risk of Cancer: Accumulating Evidence from Prospective Studies.
Nutrients, , Aug-20, Volume: 12, Issue:9 | 2020 |
Dietary intake of polyunsaturated fatty acids alleviates cognition deficits and depression-like behaviour via cannabinoid system in sleep deprivation rats.
Behavioural brain research, , 04-20, Volume: 384 | 2020 |
Preparation of High-Purity Trilinolein and Triolein by Enzymatic Esterification Reaction Combined with Column Chromatography.
Journal of oleo science, , Feb-01, Volume: 68, Issue:2 | 2019 |
The Use of Gene Ontology Term and KEGG Pathway Enrichment for Analysis of Drug Half-Life.
PloS one, , Volume: 11, Issue:10 | 2016 |
PPAR-α, a lipid-sensing transcription factor, regulates blood-brain barrier efflux transporter expression.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 37, Issue:4 | 2017 |
Characterization of unsaturated fatty acid sustained-release microspheres for long-term algal inhibition.
Chemosphere, , Volume: 120 | 2015 |
Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies.
Circulation, , Oct-28, Volume: 130, Issue:18 | 2014 |
Is there an optimal dose for dietary linoleic acid? Lessons from essential fatty acid deficiency supplementation and adipocyte functions in rats.
Journal of physiology and biochemistry, , Volume: 70, Issue:2 | 2014 |
A polyethylenimine-linoleic acid conjugate for antisense oligonucleotide delivery.
BioMed research international, , Volume: 2013 | 2013 |
N-6 and N-3 fatty acid cholesteryl esters in relation to fatal CHD in a Dutch adult population: a nested case-control study and meta-analysis.
PloS one, , Volume: 8, Issue:5 | 2013 |
Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially.
Journal of the Academy of Nutrition and Dietetics, , Volume: 113, Issue:2 | 2013 |
Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells.
Lipids in health and disease, , Jul-10, Volume: 11 | 2012 |
Identification of enriched conjugated linoleic acid isomers in cultures of ruminal microorganisms after dosing with 1-(13)C-linoleic acid.
Journal of microbiology (Seoul, Korea), , Volume: 49, Issue:4 | 2011 |
Chronic and acute effects of walnuts on antioxidant capacity and nutritional status in humans: a randomized, cross-over pilot study.
Nutrition journal, , May-12, Volume: 9 | 2010 |
Dosage plan of a flurbiprofen injection product using inhibition of protein binding by lipid emulsion in rats.
The Journal of pharmacy and pharmacology, , Volume: 60, Issue:1 | 2008 |
Phytotoxic Eremophilanes from Ligularia macrophylla.
Journal of agricultural and food chemistry, , Dec-26, Volume: 55, Issue:26 | 2007 |
Whole body distribution of deuterated linoleic and alpha-linolenic acids and their metabolites in the rat.
Journal of lipid research, , Volume: 48, Issue:12 | 2007 |
Effect of conjugated linoleic acid type, treatment period, and dosage on differentiation of 3T3 cells.
Lipids, , Volume: 41, Issue:10 | 2006 |
An oxidized metabolite of linoleic acid increases intracellular calcium in rat adrenal glomerulosa cells.
American journal of physiology. Endocrinology and metabolism, , Volume: 291, Issue:6 | 2006 |
The production of 10-hydroxystearic and 10-ketostearic acids is an alternative route of oleic acid transformation by the ruminal microbiota in cattle.
The Journal of nutrition, , Volume: 136, Issue:4 | 2006 |
In vivo conversion of 18- and 20-C essential fatty acids in rats using the multiple simultaneous stable isotope method.
Journal of lipid research, , Volume: 46, Issue:9 | 2005 |
Simultaneous quantitative determination of deuterium- and carbon-13-labeled essential fatty acids in rat plasma.
Journal of lipid research, , Volume: 46, Issue:9 | 2005 |
Antioxidative activity and protective effect against ethanol-induced gastric mucosal damage of a potato protein hydrolysate.
Journal of nutritional science and vitaminology, , Volume: 49, Issue:6 | 2003 |
Linoleic acid induces interleukin-8 production by Crohn's human intestinal smooth muscle cells via arachidonic acid metabolites.
American journal of physiology. Gastrointestinal and liver physiology, , Volume: 286, Issue:4 | 2004 |
The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, , Volume: 27, Issue:7 | 2003 |
Relative potencies of statins in reducing cholesterol synthesis and enhancing linoleic acid metabolism.
European journal of pharmacology, , Apr-25, Volume: 467, Issue:1-3 | 2003 |
The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors.
Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6 | 2003 |
Differential effects of linoleic Acid metabolites on cardiac sodium current.
The Journal of pharmacology and experimental therapeutics, , Volume: 303, Issue:1 | 2002 |
Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats.
Japanese journal of cancer research : Gann, , Volume: 93, Issue:2 | 2002 |
Conjugated linoleic acid reduces body fat in healthy exercising humans.
The Journal of international medical research, , Volume: 29, Issue:5 | |
Application of new methods and analytical approaches to research on polyunsaturated fatty acid homeostasis.
Lipids, , Volume: 36, Issue:9 | 2001 |
Who's afraid of n-6 polyunsaturated fatty acids? Methodological considerations for assessing whether they are harmful.
Nutrition, metabolism, and cardiovascular diseases : NMCD, , Volume: 11, Issue:3 | 2001 |
Effect of forage:concentrate ratio on ruminal digestion and duodenal flow of fatty acids in ewes.
Journal of animal science, , Volume: 79, Issue:8 | 2001 |
1-14C-linoleic acid distribution in various tissue lipids of guinea pigs following an oral dose.
Lipids, , Volume: 36, Issue:3 | 2001 |
Dietary fat intake, supplements, and weight loss.
Canadian journal of applied physiology = Revue canadienne de physiologie appliquee, , Volume: 25, Issue:6 | 2000 |
Conjugated linoleic acid reduces body fat mass in overweight and obese humans.
The Journal of nutrition, , Volume: 130, Issue:12 | 2000 |
Characterization of RCI-1, a chloroplastic rice lipoxygenase whose synthesis is induced by chemical plant resistance activators.
European journal of biochemistry, , Volume: 267, Issue:19 | 2000 |
Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid.
Journal of pharmaceutical sciences, , Volume: 89, Issue:10 | 2000 |
Conjugated linoleic acid and disease prevention: a review of current knowledge.
Journal of the American College of Nutrition, , Volume: 19, Issue:2 Suppl | 2000 |
Dietary trans fatty acids affect the essential fatty-acid concentration of rat milk.
The Journal of nutrition, , Volume: 130, Issue:4 | 2000 |
Effects of capsaicin on biliary free fatty acids in rats.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, , Volume: 70, Issue:1 | 2000 |
Comparison of bolus versus fractionated oral applications of [13C]-linoleic acid in humans.
European journal of clinical investigation, , Volume: 29, Issue:7 | 1999 |
Decrease in linoleic acid metabolites as a potential mechanism in cancer risk reduction by conjugated linoleic acid.
Carcinogenesis, , Volume: 20, Issue:6 | 1999 |
An increase in vitamin A status by the feeding of conjugated linoleic acid.
Nutrition and cancer, , Volume: 33, Issue:1 | 1999 |
Dietary hydroperoxides of linoleic acid decompose to aldehydes in stomach before being absorbed into the body.
Biochimica et biophysica acta, , Aug-28, Volume: 1393, Issue:2-3 | 1998 |
Catabolic fate of dietary trilinoleoylglycerol hydroperoxides in rat gastrointestines.
Biochimica et biophysica acta, , Aug-28, Volume: 1393, Issue:2-3 | 1998 |
Effect of dietary arachidonic acid on metabolism of deuterated linoleic acid by adult male subjects.
Lipids, , Volume: 33, Issue:5 | 1998 |
Modulation of adjuvant-induced arthritis by dietary arachidonic acid in essential fatty acid-deficient rats.
Lipids, , Volume: 32, Issue:9 | 1997 |
Linoleate, alpha-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys.
Journal of lipid research, , Volume: 37, Issue:12 | 1996 |
Essential fatty acid uptake and metabolism in the developing rodent brain.
Lipids, , Volume: 31 Suppl | 1996 |
Effects of two dietary fat levels and four dietary linoleic acid levels on mammary tumor development in Balb/c-MMTV mice under ad libitum feeding conditions.
Nutrition and cancer, , Volume: 25, Issue:2 | 1996 |
Risk factors for Barrett's oesophagus: a life history approach to behavioural assessment in the distant past.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), , Volume: 4, Issue:6 | 1995 |
Effects of linoleate-enriched and oleate-enriched diets in combination with alpha-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans.
Arteriosclerosis and thrombosis : a journal of vascular biology, , Volume: 14, Issue:4 | 1994 |
[Platelet aggregation and platelet and plasma fatty acid levels in the child with migraine. Apropos of 40 case reports].
Pediatrie, , Volume: 38, Issue:8 | 1983 |
Linoleic acid and arachidonic acid metabolism in human peripheral blood leucocytes: comparison with the rat.
The British journal of nutrition, , Volume: 51, Issue:2 | 1984 |
Promotion of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis by high dietary fat in the rat: possible role of intercellular communication.
Journal of the National Cancer Institute, , Volume: 72, Issue:3 | 1984 |
Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells.
Biochimica et biophysica acta, , May-18, Volume: 928, Issue:3 | 1987 |
Fat and endocrine-responsive cancer in animals.
Preventive medicine, , Volume: 16, Issue:4 | 1987 |
[Effects of equal amounts of linoleic acid in orally administered, polyunsaturated phospholipids or in safflower oil on blood lipoproteins].
Klinische Wochenschrift, , Oct-15, Volume: 65, Issue:20 | 1987 |
Inhibition of growth and linoleate-enhanced metastasis of a transplantable mouse mammary tumor by indomethacin.
Cancer letters, , Dec-01, Volume: 43, Issue:1-2 | 1988 |
Effect of varying concentrations of linoleic acid on alpha-adrenoceptor responses in spontaneously hypertensive rats.
Prostaglandins, leukotrienes, and essential fatty acids, , Volume: 33, Issue:2 | 1988 |
The effect of donor-specific blood transfusion, cyclosporine, and dietary prostaglandin precursors on rat cardiac allograft survival. II. Effectiveness of a 24-hour induction period with DST and CsA in inducing long-term graft survival.
Transplantation, , Volume: 47, Issue:1 | 1989 |
Effects of dietary pantethine levels on drug-metabolizing system in the liver of rats orally administered varying amounts of autoxidized linoleate.
Journal of nutritional science and vitaminology, , Volume: 35, Issue:4 | 1989 |
Dietary lipid modulation of myocardial beta-adrenergic mechanisms, Ca2+-dependent automaticity, and arrhythmogenesis in the marmoset.
Journal of cardiovascular pharmacology, , Volume: 10, Issue:3 | 1987 |
Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen.
Endocrinology, , Volume: 126, Issue:2 | 1990 |
Effects of dietary pantethine levels on contents of fatty acids and thiobarbituric acid reactive substances in the liver of rats orally administered varying amounts of autoxidized linoleate.
Journal of nutritional science and vitaminology, , Volume: 37, Issue:1 | 1991 |
Characterization of the insulinotropic potency of polyunsaturated fatty acids.
Endocrinology, , Volume: 130, Issue:2 | 1992 |
Hydrogenation alternatives: effects of trans fatty acids and stearic acid versus linoleic acid on serum lipids and lipoproteins in humans.
Journal of lipid research, , Volume: 33, Issue:3 | 1992 |
Differential effects of dietary linoleic acid on mouse skin-tumor promotion and mammary carcinogenesis.
Cancer research, , Apr-01, Volume: 52, Issue:7 Suppl | 1992 |
Interactions (7)
| Article | Year |
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Metabolomics Combined with Network Pharmacology-Based Strategy to Reveal the Underlying Mechanism of Zhenhuang Submicron Emulsion in Treating Oropharyngeal Mucositis Complications of Radiation Therapy for Head and Neck Cancer.
Drug design, development and therapy, , Volume: 16 | 2022 |
Preparation of High-Purity Trilinolein and Triolein by Enzymatic Esterification Reaction Combined with Column Chromatography.
Journal of oleo science, , Feb-01, Volume: 68, Issue:2 | 2019 |
Additional benefit in CVD risk indices derived from the consumption of fortified milk when combined with a lifestyle intervention.
Public health nutrition, , Volume: 17, Issue:2 | 2014 |
Fish oil in combination with high or low intakes of linoleic acid lowers plasma triacylglycerols but does not affect other cardiovascular risk markers in healthy men.
The Journal of nutrition, , Volume: 138, Issue:6 | 2008 |
Conjugated linoleic acid in combination with supplemental dietary fat alters pork fat quality.
The Journal of nutrition, , Volume: 132, Issue:10 | 2002 |
Therapeutic effect of topical application of linoleic acid and lincomycin in combination with betamethasone valerate in melasma patients.
Journal of Korean medical science, , Volume: 17, Issue:4 | 2002 |
Antitumor activity of D-mannosamine in vitro: cytotoxic effect produced by mannosamine in combination with free fatty acids on human leukemia T-cell lines.
Japanese journal of clinical oncology, , Volume: 15, Issue:3 | 1985 |