An aminopeptidase N that is encoded in the genome of pig. [OMA:P15145, PRO:DNx]
Design, Synthesis, and Biological Evaluation of APN and AKT Dual-Target Inhibitors.ACS medicinal chemistry letters, , Dec-09, Volume: 12, Issue:12, 2021
Synthesis and biological characterization of ubenimex-fluorouracil conjugates for anti-cancer therapy.European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library.Bioorganic & medicinal chemistry, , 09-01, Volume: 25, Issue:17, 2017
Design, synthesis, and biological characterization of tamibarotene analogs as anticancer agents.Chemical biology & drug design, , Volume: 88, Issue:4, 2016
Discovery of BC-01, a novel mutual prodrug (hybrid drug) of ubenimex and fluorouracil as anticancer agent.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Discovery of a novel chimeric ubenimex-gemcitabine with potent oral antitumor activity.Bioorganic & medicinal chemistry, , 11-15, Volume: 24, Issue:22, 2016
Synthesis of chiral ND-322, ND-364 and ND-364 derivatives as selective inhibitors of human gelatinase.Bioorganic & medicinal chemistry, , Oct-15, Volume: 23, Issue:20, 2015
Design, synthesis and preliminary evaluation of α-sulfonyl γ-(glycinyl-amino)proline peptidomimetics as matrix metalloproteinase inhibitors.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Design, synthesis and preliminary activity evaluation of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as aminopeptidase N/CD13 inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:3, 2013
Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN).Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 23, Issue:17, 2013
Discovery of a synthetic Aminopeptidase N inhibitor LB-4b as a potential anticancer agent.Bioorganic & medicinal chemistry letters, , May-01, Volume: 23, Issue:9, 2013
Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN).Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Design, synthesis and biological evaluation of novel L-isoserine tripeptide derivatives as aminopeptidase N inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:4, 2013
Synthesis of amino-hydroxy-benzocycloheptenones as potent, selective, non-peptidic dinuclear zinc metalloaminopeptidase inhibitors.Bioorganic & medicinal chemistry, , Nov-01, Volume: 21, Issue:21, 2013
Novel indoline-2,3-dione derivatives as inhibitors of aminopeptidase N (APN).Bioorganic & medicinal chemistry, , May-01, Volume: 21, Issue:9, 2013
Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors.Bioorganic & medicinal chemistry, , Jun-15, Volume: 20, Issue:12, 2012
Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors.Bioorganic & medicinal chemistry, , Aug-15, Volume: 20, Issue:16, 2012
Development of Synthetic Aminopeptidase N/CD13 Inhibitors to Overcome Cancer Metastasis and Angiogenesis.ACS medicinal chemistry letters, , Dec-13, Volume: 3, Issue:12, 2012
Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:2, 2012
A novel aminopeptidase N inhibitor developed by virtual screening approach.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 22, Issue:18, 2012
Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine.Bioorganic & medicinal chemistry, , Sep-01, Volume: 19, Issue:17, 2011
Design, synthesis and biological evaluation of novel 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as aminopeptidase N/CD13 inhibitors.Bioorganic & medicinal chemistry, , Oct-15, Volume: 19, Issue:20, 2011
Design, synthesis and biological evaluation of novel L-lysine ureido derivatives as aminopeptidase N inhibitors.Bioorganic & medicinal chemistry, , Jan-15, Volume: 19, Issue:2, 2011
New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13.Bioorganic & medicinal chemistry, , Apr-15, Volume: 18, Issue:8, 2010
Novel aminopeptidase N (APN/CD13) inhibitors derived from 3-phenylalanyl-N'-substituted-2,6-piperidinedione.Bioorganic & medicinal chemistry, , Aug-15, Volume: 18, Issue:16, 2010
Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Design, chemistry and activity evaluation. Part I.European journal of medicinal chemistry, , Volume: 44, Issue:12, 2009
Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 17, Issue:7, 2009
Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors.Bioorganic & medicinal chemistry, , Jun-01, Volume: 17, Issue:11, 2009
Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part II).Bioorganic & medicinal chemistry, , Apr-15, Volume: 17, Issue:8, 2009
Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I).Bioorganic & medicinal chemistry, , Apr-15, Volume: 17, Issue:8, 2009
Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13.Bioorganic & medicinal chemistry, , Oct-15, Volume: 17, Issue:20, 2009
Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN).Bioorganic & medicinal chemistry, , Dec-01, Volume: 16, Issue:23, 2008
First synthesis of alpha-aminoalkyl-(N-substituted)thiocarbamoyl-phosphinates: inhibitors of aminopeptidase N (APN/CD13) with the new zinc-binding group.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 18, Issue:13, 2008
Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold.Bioorganic & medicinal chemistry, , Jul-15, Volume: 16, Issue:14, 2008
A library of novel hydroxamic acids targeting the metallo-protease family: design, parallel synthesis and screening.Bioorganic & medicinal chemistry, , Jan-01, Volume: 15, Issue:1, 2007
Novel 3-galloylamido-N'-substituted-2,6-piperidinedione-N-acetamide peptidomimetics as metalloproteinase inhibitors.Bioorganic & medicinal chemistry letters, , May-15, Volume: 17, Issue:10, 2007
Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors.Bioorganic & medicinal chemistry, , Nov-01, Volume: 14, Issue:21, 2006
Nonpeptide small-molecular inhibitors of dipeptidyl peptidase IV: N-phenylphthalimide analogs.Bioorganic & medicinal chemistry letters, , Feb-22, Volume: 9, Issue:4, 1999
Synthesis of sulfur-containing analogues of bestatin. Inhibition of aminopeptidases by alpha-thiolbestatin analogues.Journal of medicinal chemistry, , Volume: 31, Issue:11, 1988
New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties.Journal of medicinal chemistry, , Volume: 28, Issue:9, 1985