Page last updated: 2024-08-07 12:50:59
Neuraminidase
A neuraminidase subtype N1 (Influenza A virus) that is encoded in the genome of the H1N1 strain A/Puerto Rico/8/1934. [PMID:11779399, PMID:15163504, PMID:15567494, PMID:15744059, PMID:16192481, PMID:6927853, PMID:7010182, PRO:CNA, UniProtKB:P03468]
Synonyms
EC 3.2.1.18
Research
Bioassay Publications (31)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (22.58) | 18.2507 |
| 2000's | 7 (22.58) | 29.6817 |
| 2010's | 11 (35.48) | 24.3611 |
| 2020's | 6 (19.35) | 2.80 |
Compounds (20)
Drugs with Inhibition Measurements
[no title available]Journal of medicinal chemistry, , 09-08, Volume: 65, Issue:17, 2022
Identification of C5-NHJournal of medicinal chemistry, , 12-23, Volume: 64, Issue:24, 2021
Discovery of novel 1,2,3-triazole oseltamivir derivatives as potent influenza neuraminidase inhibitors targeting the 430-cavity.European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.Journal of medicinal chemistry, , Jul-26, Volume: 61, Issue:14, 2018
Synthesis and anti-influenza virus evaluation of triterpene-sialic acid conjugates.Bioorganic & medicinal chemistry, , 01-01, Volume: 26, Issue:1, 2018
Limited inhibitory effects of oseltamivir and zanamivir on human sialidases.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:10, 2008
Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides.Bioorganic & medicinal chemistry letters, , Mar-12, Volume: 11, Issue:5, 2001
Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity.Journal of medicinal chemistry, , Dec-06, Volume: 44, Issue:25, 2001
Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.Journal of medicinal chemistry, , Apr-12, Volume: 44, Issue:8, 2001
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.Journal of medicinal chemistry, , Sep-21, Volume: 43, Issue:19, 2000
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.Journal of medicinal chemistry, , Mar-12, Volume: 41, Issue:6, 1998
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.Journal of medicinal chemistry, , Mar-12, Volume: 41, Issue:6, 1998
Total synthesis of dryocrassin ABBA and its analogues with potential inhibitory activity against drug-resistant neuraminidases.Bioorganic & medicinal chemistry, , 09-01, Volume: 27, Issue:17, 2019
C-Methylated Flavonoid Glycosides from Pentarhizidium orientale Rhizomes and Their Inhibitory Effects on the H1N1 Influenza Virus.Journal of natural products, , 10-27, Volume: 80, Issue:10, 2017
Synthesis and biological evaluation of NHEuropean journal of medicinal chemistry, , Dec-01, Volume: 141, 2017
Discovery of berberine based derivatives as anti-influenza agent through blocking of neuraminidase.Bioorganic & medicinal chemistry, , 10-15, Volume: 25, Issue:20, 2017
Limited inhibitory effects of oseltamivir and zanamivir on human sialidases.Antimicrobial agents and chemotherapy, , Volume: 52, Issue:10, 2008
Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity.Journal of medicinal chemistry, , Dec-06, Volume: 44, Issue:25, 2001
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.Journal of medicinal chemistry, , Sep-21, Volume: 43, Issue:19, 2000
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.Journal of medicinal chemistry, , Mar-12, Volume: 41, Issue:6, 1998
Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity.Journal of medicinal chemistry, , Dec-06, Volume: 44, Issue:25, 2001
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.Journal of medicinal chemistry, , Sep-21, Volume: 43, Issue:19, 2000
Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: the hydrophobic side chain influences type A subtype selectivity.Bioorganic & medicinal chemistry, , Jul-15, Volume: 20, Issue:14, 2012
Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituent.Journal of medicinal chemistry, , Jul-01, Volume: 42, Issue:13, 1999
[no title available]Journal of medicinal chemistry, , 09-08, Volume: 65, Issue:17, 2022
Identification of C5-NHJournal of medicinal chemistry, , 12-23, Volume: 64, Issue:24, 2021
Discovery of hydrazide-containing oseltamivir analogues as potent inhibitors of influenza A neuraminidase.European journal of medicinal chemistry, , Oct-05, Volume: 221, 2021
Design, synthesis and biological evaluation of oseltamivir derivatives containing pyridyl group as potent inhibitors of neuraminidase for influenza A.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Design, synthesis and biological evaluation of substituted flavones and aurones as potential anti-influenza agents.Bioorganic & medicinal chemistry, , 01-01, Volume: 28, Issue:1, 2020
Discovery of novel 1,2,3-triazole oseltamivir derivatives as potent influenza neuraminidase inhibitors targeting the 430-cavity.European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Boronate, trifluoroborate, sulfone, sulfinate and sulfonate congeners of oseltamivir carboxylic acid: Synthesis and anti-influenza activity.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
[no title available]European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1.Bioorganic & medicinal chemistry, , 07-01, Volume: 27, Issue:13, 2019
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.Journal of medicinal chemistry, , Jul-26, Volume: 61, Issue:14, 2018
Fragment-based drug discovery.Journal of medicinal chemistry, , Jul-01, Volume: 47, Issue:14, 2004
Carbocyclic influenza neuraminidase inhibitors possessing a C3-cyclic amine side chain: synthesis and inhibitory activity.Bioorganic & medicinal chemistry letters, , Jun-05, Volume: 10, Issue:11, 2000
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.Journal of medicinal chemistry, , Sep-21, Volume: 43, Issue:19, 2000
Stereospecific synthesis of a GS 4104 metabolite: determination of absolute stereochemistry and influenza neuraminidase inhibitory activity.Bioorganic & medicinal chemistry letters, , Oct-04, Volume: 9, Issue:19, 1999
Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors.Journal of medicinal chemistry, , Jul-02, Volume: 41, Issue:14, 1998
A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 8, Issue:23, 1998